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Ph.D Thesis (Dr. Bilal) 104

The effect of Rheum emodi on wound healing was assessed in three age groups of

rabbits. Following conclusion can be drawn from the present study.

Rheum emodi can activate wound healing process for early and fast healing.

It shows a strong pro-healing potential as it induces excessive accumulation of

hydroxyproline, glucosamine, protein and DNA to the wound site and thus

triggering early wound closure.

Rheum emodi enhances the expression of wound healing genes thereby triggers

the pro-healing convergence pathway.

The group A and group B treated animals showed significant wound contraction,

increased accumulation of hydroxyproline, glucosamine, protein, DNA and

enhanced expression of Ccr1, EGF, K6 and Egr-1 in both treated and control

wounds. This increased accumulation of chemical constituents and enhanced

expression of wound healing genes may also be attributed to the younger age of

group A and group B animals apart from Rheum emodi.

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