The Dietary Supplement Ingredient Database: Results of ......The Dietary Supplement Ingredient...
Transcript of The Dietary Supplement Ingredient Database: Results of ......The Dietary Supplement Ingredient...
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The Dietary Supplement Ingredient Database:
Results of USDA Pilot Studies
Presented by Joanne M. Holden, USDA, Agricultural Research Service, Nutrient
Data Laboratory
Agricultural ResearchService
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USDA Authors
Joanne Holden, Karen Andrews, Janet Roseland, Cuiwei Zhao, Amy Schweitzer,
Nutrient Data Laboratory
Wayne Wolf and James HarnlyFood Composition Laboratory
Charles PerryNational Agriculture and Statistics
Service
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NIH Authors
Johanna Dwyer, Leila Saldanha, Mary Frances Picciano, Kenneth Fisher,
Elizabeth Yetley, Joseph Betz
Office of Dietary SupplementsNational Institutes of Health
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CDC and NIST Authors
Kathy Radimer and Bernadette BindewaldNational Center for Health Statistics,
Centers for Disease Control and Prevention, US Department of Health and
Human Services
Kathy SharplessNational Institute of Standards and
Technology
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Assessment of Intake
Food Food IntakeIntake
Component Component ValuesValues
Total Total Component Component
IntakeIntake
Supplement Intake
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USDA Database Products
USDA National Nutrient Database for Standard Reference Database for national food and nutrition surveysDatabase for bioactive componentsFactors, guidelines, and protocols
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NDL’s Foodcomp Web site
www.nal.usda.gov/fnic/foodcomp
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NHANES: What We Eat in America
National Health and Nutrition Examination Survey of nearly 5,000 individuals annuallyFood intake assessed with two 24-hour dietary recallsSupplement intake assessed over past monthDS nutrient values obtained from labels
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Assessment of Vitamin -- Mineral Intake for Foods
FOODSFOODSStandard Reference (SR)
NHANES Food Intake Data
Food and NutrientDatabase for
Dietary Studies (FNDDS)
NHANES Nutrient Intake Reports
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Assessment of Vitamin -Mineral Intake for Foods and Dietary Supplements
Standard Reference (SR)
NHANES Food Intake Data
NHANES Food Nutrient Reports
Total Intake of V + M
FOODSFOODS
Food and NutrientDatabase for
Dietary Studies (FNDDS)
NHANES Dietary Supplement Label Database
NDL Research Findings
NHANES Supplement Intake Data
Supplement Ingredient Intake Data
DIETARY SUPPLEMENTS
Dietary Supplement Ingredient
Database (DSID)
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NHANES Dietary Supplement Database
Database contains 6000+ products reported by respondentsProducts include multivitamins, single vitamins/minerals, botanicals, amino acidsNutrition information in database is based on label valuesPartnership with NCHS
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Today’s Objectives
Goals for a DSIDKey ChallengesPilot Study QuestionsPilot Study AccomplishmentsFuture Plans
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Goals for Dietary Supplement Ingredient Database
To develop reliable estimates of nutrients and other bioactive components in Dietary Supplements To release and maintain on-line DS databaseTo assess variability and/or possible bias in nutrient levels for DS
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Key Challenges
Categorization/ Description
Identifying Priorities
Sample HandlingRepresentative Sampling Plans
Unique Matrix Qualified Labs
DSID
Methods and Reference Materials
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Categorizing Product Types
Defining a dietary supplementClassifying various dietary supplements availableDefining a multivitamin/multimineral (MVM)Partners with NCHS
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Diverse Product Types
MultivitaminsCondition-specific products: joint health, bone health, memoryBotanicals Weight-loss products
Sport performance productsSpecialty products: amino acids, enzymes, melatonin, plant oils, glucosamine, probiotics
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0
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3 4 5 6 7 8 9 10 11 12 13 14 15 16 17Number of Vitamins
Wei
ghte
d Fr
eque
ncy
of U
se (/
1,00
0,00
0)Distribution of Vitamin Count in Adult
Multivitamin/Minerals*
*Distribution of vitamins (>2) indicates that the most commonly reported adult multivitamins (NHANES 1999-2000) contain 13 vitamins.
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Distribution of Mineral Count in Adult Multivitamin/Minerals*
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16Number of Minerals
Wei
ghte
d Fr
eque
ncy
of U
se
(/1,0
00,0
00)
*Distribution indicates that most products reported (NHANES 1999-2000) are either single or double mineral products or are multivitamin/mineral products with 16 minerals.
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Identifying priority components
Criteria considered:Criteria considered:
Frequency of consumption: NHANESFrequency of consumption: NHANESPublic health significance Public health significance Status of methods and reference Status of methods and reference materialsmaterialsFederal agency interestFederal agency interest
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Highest Priority Categories
Multivitamins/minerals(MVMs)AntacidsCalcium SupplementsVitamin EVitamin CB Vitamin productsCaffeine-containing products
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Highest Priority “Tier 1”Ingredients
Folic Acid/folate Calcium
Vitamin EVitamin A (Retinol)
Vitamin CIron
Beta Carotene
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“Tier 2” Ingredients
PotassiumCopper
SeleniumChromiumManganeseMagnesium
ZincIodine
RiboflavinThiaminNiacin
Vitamin B6Vitamin B12Vitamin DVitamin K
Phosphorus
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Representative Sampling Plans
Identify products: NHANESSelect across distribution channels
Mass market retailNatural food and health storesMulti-level marketingDirect sales
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Specific Methodology Issues for MVMs
Unique matrix effects of capsules, pills, and gel caps
Sample handling of MVMs for accuracy and precision
Selection of valid methodsDevelopment of reference materialQualifying labs
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Development of Reference Materials (RMs)
RM (known value) is measured along with sample MVM (unknown value)NIST is developing an RM for DSODS, NIST, and FCL are partnering with NDL to:
Characterize SRMsReview analytical methodsQualify labs
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Pilot Study Goals
Pilot Study 1: Survey laboratories for standard analytical methods. Identify sample handling protocols for MVMs to insure complete recovery.
Pilot Study 2: Assess capabilities of qualified labs to determine nutrient values of MVMs.
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Alpha-tocopherol Values for 2 Multivitamin/minerals and a Reference Material
Products AnalyzedMVM 1 MVM 2 Reference Material
mg/g A
lpha-tocopherol 0.000.030.060.090.120.15
10.00
15.00
20.00
25.00
30.00
35.00
40.00
45.00
Lab 1Lab 2Lab 5Lab 6Known Value
Label Value
Label Value
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Levels of Alpha Tocopherol in Food and Supplements
1 Tbsp safflower oil = 5 mg alpha tocopherol* in natural form = 37% DV
1 oz dry roasted almonds = 7 mg alpha tocopherol* in natural form = 52% DV
Common MVM = 30 IU (13.5 mg) synthetic alpha tocopherol = 100% DV
*U.S. Department of Agriculture, Agricultural Research Service. 2005. USDA National Nutrient Database for Standard Reference, Release 18. Nutrient Data Laboratory Home Page, http://www.nal.usda.gov/fnic/foodcomp, Accessed October 19, 2005
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Coefficient of Variation (%) for Laboratories Analyzing Tier 1 Nutrients in a Multivitamin/mineral Product
0
5
10
15
20
25
30
35
Folic acid A-tocopherol
Iron AscorbicAcid
Calcium B-Carotene
Retinol
Nutrients
Coe
ffici
ent o
f Var
iatio
n (%
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Key Accomplishments
Categorization/ Description
Identifying Priorities
Sample HandlingRepresentative Sampling Plans
Unique Matrix Qualified Labs
DSID
Methods and Reference Materials
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Key Accomplishments
Categorization/ Categorization/ Description
Identifying Identifying PrioritiesDescription Priorities
Sample HandlingRepresentative Sampling Plans
Unique Matrix Qualified Labs
DSID
Methods and Reference Materials
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Key Accomplishments
Categorization/ Categorization/ Description
Identifying Identifying PrioritiesDescription Priorities
Sample HandlingRepresentative Representative Sampling PlansSampling Plans
Unique Matrix Qualified Labs
DSID
Methods and Reference Materials
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Key Accomplishments
Categorization/ Categorization/ Description
Identifying Identifying PrioritiesDescription Priorities
Sample HandlingSample HandlingRepresentative Representative Sampling PlansSampling Plans
Unique MatrixUnique Matrix Qualified Labs
DSID
Methods and Reference Materials
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Key Accomplishments
Categorization/ Categorization/ Description
Identifying Identifying PrioritiesDescription Priorities
Sample HandlingSample HandlingRepresentative Representative Sampling PlansSampling Plans
Unique MatrixUnique Matrix Qualified LabsQualified Labs
DSID
Methods and ReferenceMethods and Reference MaterialsMaterials
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Next Steps: The “% DV” study
Compare label and actual values of MVMs.
Choose products at 3 or 4 DV levels. Analyze 5 products from each DV level.Measure 2 lots per product.
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Example: Most Common % DV Levels for Calcium in Adult Multivitamins
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16% 20% 45%
Calcium% DV of Calcium
%of
wei
ghte
d fr
eque
ncy
of u
se*
*NHANES 01-02
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Example: Most Common % DV Levels forVitamin C in Adult Multivitamins
0
20
40
60
80
100
100% 200% 417%
Vitamin C% DV of Vitamin C
% o
f wei
ghte
d fr
eque
ncy
of u
se*
*NHANES 01-02
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Comparison of % DV Label Claims vs. Laboratory Data, Theoretical Results
Products labeled at 50, 100,150 %DV
50-1
50-2
50-3
50-4
50-5
100-
110
0-2
100-
310
0-4
100-
515
0-1
150-
215
0-3
150-
415
0-5
Theo
retic
al L
abor
ator
y D
ata,
%D
V
20
40
60
80
100
120
140
160
180
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Application of Pilot Study Results
Plans to analyze representative MVMs to support estimates for MVMs reported in NHANES.Validate composition data for generic classes of dietary supplements.
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USDA Database Products
USDA National Nutrient Database for Standard Reference Database for national food and nutrition surveysDatabase for bioactive componentsFactors, guidelines, and protocolsDietary Supplement Ingredients Database
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Summary
Pilot studies can refine questions and focus research for the development of a dietary
supplement ingredient database.
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Acknowledgements
Funded by Office of Dietary Supplements, National Institutes of Health
http://Nutrition.govhttp://ods.od.nih.gov
DSID group
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Questions?