The Department of Pathology at CWRU/UHCMC

Missions: To Heal. To Teach. To Discover.

Cutting Edge Clinical Diagnostics. Clinical and Research Education. Basic, Translational and Clinical Research.

Pathology department roles are very much engaged in service to and collaboration with other departments:

1. Clinical: Serve needs of patients and clinicians from other departments for diagnostic tests.2. Research: Many collaborations in basic, translational and clinical research. Basic end of translational research. Tissue based research.3. Research education: Pathology graduate program is explicitly designed to engage interdepartmental participation and is well suited to many clinical faculty in Medicine given the focus areas of disease mechanisms, cancer, immunology/I.D.

32 CWRU-employed Expt Path (1 part-time)

1 CWRU-employed Anatomy Ed

25 UHMG-employed (3 part-time)

12 Case-UHMG dual-employed (AP-9,CP-3;)

5 UHMP-employed

4 UHCMC-employed

Total 79 (includes part time & 1-yr Clin

Instruct x 2)

Department of Pathology, 2013

Pathology Faculty (1° at CWRU/UHCMC) June 2015

(Not counted: PRNs; Medical examiner’s office, VA)

Chair of PathologyC. Harding, MD, PhD

Administrative Director

C. Zimerla (Admin Director: CWRU &

UHMG)(6.5 FTE CWRU; 1.5

UHMG, others UHCMC90 res staff

~23 Postdocs~51 PhD stud)

(1° faculty, 16; 2° faculty, 3)• Clinical Chemistry – Schmotzer, Noguez• Microbiology – Jacobs• Hematology - Myerson, Sandhaus, Beck• Flow Cytometry - Meyerson, Beck• Coagulation - Downes• Blood Bank/Apheresis – Downes, Zhou,

Maitta, Reeves• HLA Lab – Greenspan, Wald• Molecular Dx - Zhou• Clinical Immunology – Kaplan• Point of Care Testing – Sandhaus• Genetics - Cytogenetics & Prenatal – Pfau - Molecular Genetics – Zhang• CIDEM – Kerr (Peds), McCandless (CHG)

2°• Mycology – Ghannoum (Derm) 2°• UHTL - Quinones

Vice Chair-Clinical AffairsMedical Director

J. Willis, MD

Division of AnatomicPathology

G. MacLennan, MD(24 faculty )

SurgicalPathology

Hannah Gilmore, MD

AutopsyPathologyW. Xin, MD

CytologyJ. Wasman, MD

Administrative DirectorUHCMC/UHLSF Labs

D. Landek

UHCMC/UHLSF LabsManagerial/Technical Staff

~337 FTEs

Division of Clinical

PathologyJ. Willis, MD

Division of CommunityHosp Path

A. Zaher, M.D.(5 faculty)

AhujaGeauga

RichmondBedford

UHC SVP OpsR. Dziedzicki

UHPSM. Nochomovitz, MD

CWRU SOMP. Davis, MD, PhD

UHCMCF. Rothstein, MD

79 faculty CWRU/UH (1°)~15 other 1° (Med Exam, VA)~48 secondary & ~21 adjunct~33 PhD trainers not 1° or 2°

Pathology Academic Affairs

ResidencyG MacLennan MD, PhD

W. Xin, MD (AP), C. Schmotzer, MD (CP), R,

Elliott, MD

PhD ProgramJ Anderson, MD, PhD

R Petersen, PhD-ITP: B Cobb, PhD-CBTP M Jackson, PhD

MD curriculumZiats, Kaplan

Education

Red: Changed since last yearBlue: Department DivisionsGreen: Sections

Division of Experimental

Pathology33 faculty

~90 res staff~23 Postdocs~51 PhD studs

Division AP EducationT Brantley

Pathology Clinical Leadership(Overall AP/CP – see section medical directors

for specific lab areas)

AP:

Greg MacLennan, Division Chief

Hannah Gilmore, Director of Surgical Pathology

CP:

Joe Willis, Division Chief

Christine Schmotzer, Associate Division Chief

Pathology Graduate Program

Mission: Research training focused on mechanisms

of disease, including basic and translational research

Constituent Training Programs (51 PhD students)*1. Molecular & Cellular Basis of Disease Training Program

(MCBDTP): 8 students• Director: Bob Petersen, PhD.

2. Immunology Training Program (ITP) 27 students• Director: Brian Cobb, PhD.• Co-Sponsors: Infectious Diseases, Global Health, Ophthalmology,

CFAR, CCF Immunology.

3. Cancer Biology Training Program (CBTP) 16 students• Director, Mark Jackson, PhD.• Co-Sponsor: Cancer Center

*INTERDEPARTMENTAL NATURE: Majority of students in Pathology

graduate program are in labs of faculty with primary appointments in other

departments. SECONDARY OR TRAINER APPOINTMENTS.

Major Research Missions:Synergies with other departments/initiatives

1. Immunology: • Synergy with I.D., Global Health, Ophthalmology, Gastroenterology,

Dermatology, Rheumatology

• CWRU SOM Strategic Plan – Infect Immun.

2. Cancer Biology: • Synergy with Cancer Center, many depts

• CWRU SOM Strategic Plan – Cancer.

3. Neuropathology:• Synergy with Neuro Institute (Neuro Institute-BHI), Neuroscience, Peds

Heme/Onc, Cancer Center

• CWRU SOM Strategic Plan – Neuro and Cancer.

4. Other areas corresponding to clinical subspecialty areas and small basic science focus areas.

National NIH Grant Ranking#10 of 87 US NIH-funded Pathology depts (FY14)

(up from #13 in 2012, #11 in 2013)

Blue Ridge Institute for Medical Research (brimr.org)• Grants, direct plus indirect costs

From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH BRIMR.ORGRank Name Pathology

1 UNIVERSITY OF PENNSYLVANIA $43,750,152

2 JOHNS HOPKINS UNIVERSITY $42,912,905

3 EMORY UNIVERSITY $32,519,648

4 NEW YORK UNIVERSITY SCHOOL OF MEDICINE $27,467,594

5 COLUMBIA UNIVERSITY HEALTH SCIENCES $27,428,155

6 UNIVERSITY OF WASHINGTON $24,738,513

7 WASHINGTON UNIVERSITY $24,520,915

8 UNIVERSITY OF MICHIGAN $19,237,961

9 UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR $13,224,486

10 CASE WESTERN RESERVE UNIVERSITY $12,909,287

11 UNIVERSITY OF CALIFORNIA SAN DIEGO $12,886,758

12 UNIVERSITY OF MINNESOTA $11,954,531

13 STANFORD UNIVERSITY $11,207,005

14 UNIVERSITY OF ALABAMA AT BIRMINGHAM $11,167,114

15 UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA $9,115,125

16 UNIVERSITY OF CHICAGO $9,079,419

17 YALE UNIVERSITY $8,660,311

18 VANDERBILT UNIVERSITY $8,443,632

19 UNIVERSITY OF UTAH $8,443,253

20 UNIVERSITY OF PITTSBURGH AT PITTSBURGH $8,346,780

Faculty changes in Experimental Pathology July 2014-June 2015

1. Selected Arrivals: Sam Xiao, Rafick Sekaly

1. Build research and graduate training, primarily in Immunology, Cancer and Neuropathology, but including selected other areas that fit with department strengths and missions and SOM strategic plan.

2.Foster research grant success. Build successful collaborative teams.

3. Faculty recruitment in:a. Cancer research (general, Hemepath, GI Path)b. Immunology research

4.Renew training grants. (Note interdepartmental participation).

5.Contribute to institutional planning for Tissue Procurement, Biobanking with Cancer Center, UH CCRT.

Goals: Research and Graduate Education

Mission: Clinical DiagnosticsRecent Faculty Changes in Anatomic Path,

Clinical Path

1. Selected AP faculty recruitments 2014-2015: Sarah White (surgical/breast path), Dan Cowden (renal path service restart/cytology), Shahrazad Saab (surgical/peds/renal path).

2. Selected AP recruits summer/fall 2015: Qinghu Ren (surgical/GU path), Holly Harper (surgical path + Ahuja).

3. CP recruits 2014-2015: Jaime Noguez (Clin Chem).4. CP recruits summer 2015: Navid Sadri (cancer genomics),

1. Clinical Microbiology Director replacement.

2. Hematopathology replacement.

3.Surgical pathology replacement (Avril effort)

4. Surgical pathology Instructor replacement (2)

5. Immunology research (~3 positions over next 2 years).

6. Physician-scientist recruitments (CRI package): Hematopathology, GI pathology (probably in later year)

Goals: Clinical Faculty Recruitment

• IT/LIS and Informatics: Complete recruitment and organization of LIS team. Improve test reporting and ordering, develop data mining and dashboard functions, apply to test utilization/appropriate test ordering for patient care improvement and budget savings, develop informatics to apply to genomics.

• AP: Enhance sub-specialty service logistics and AP residency training organization. Tune newly launched renal pathology service.

• CP: Establish Next Gen Sequencing in clinical labs for Cancer Genomics. Enhance Mol/Gen Dx. New automated microbiology system.

Overview of selected 2015-2016 goals UHMG/UHCMC Pathology

AP subspecialty servicesFull Services: Weight1 GU 12 Lung, ENT 13 GI Large 14 GI Biopsy 15 Breast 16 Gyn Surgicals 17 Frozen section 18 Non-Gyn cytology 19 Gyn Cytology 110 Pediatric Pathology 1 Partial services:  11 Bone, soft tissue, skin 0.312 Neuropathology 0.613 Transplant/Renal 0.514 Eye Pathology 0.116 Autopsy 0.417 Medical liver 0.318 Cardiac Pathology 0.1      Total services 12.3  

Goals: Clinical Interactions

1. Interdepartmental interactions: Foster engagement of clinicians with pathologists to enhance patient care, test interpretation, utilization and reporting to meet clinical needs.

2. Clinical colleagues urged to reach out to Pathology:a. When considering changes or additions to

programs that involve laboratory/diagnostic needs.

b. To engage pathologists in discussion of test utilization and interpretation.

c. We need to work together to define new test needs/opportunities, e.g. design gene panels for NGS cancer genomics.

Goals: Research Interactions

1. Interdepartmental research interactions: Promote interdepartmental collaborations in basic, translational, clinical research.

2. Graduate Program (PhD, MD-PhD students).3. ITP Retreat.4. Tissue procurement. For tissue-based research,

pathologist is often needed to select cases, select appropriate blocks and areas, tissue; connection to pathology collaborators is important; reach out to Greg MacLennan or me. Effort support on grants when possible.