The Complement System
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The Complement System Ricklin and Lambris 2007
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The Complement System. Ricklin and Lambris 2007. Functions of the Complement System. •Viral neutralization. The Complement System. Components of the Complement System: proteins and glycoproteins synthesized mainly by liver 5% of serum circulate as zymogens - PowerPoint PPT Presentation
Transcript of The Complement System
The Complement System
Ricklin and Lambris 2007
Functions of the Complement System
•Viral neutralization
The Complement System
Components of the Complement System:
proteins and glycoproteinssynthesized mainly by liver5% of serumcirculate as zymogens
Designation of complement components:
numerals (C1-C9)letter symbols (factor D)trivial names (homologous restriction factor)
cleavage products – “a” and “b”
Complement Activation Pathways
Immunobiology (Garland Science 2005)
The Complement System
Complement Activation:
The Complement System
The Complement System
Classical Pathway requires antibody interaction:
The Complement System
•The three complement pathways converge at the membrane-attack complex (MAC).
Consequences of Complement Activation
Consequences of Complement Activation
Regulation of the Complement System
Regulation can occur at multiple steps in the complement system:Before assembly of convertase activityAfter assembly of convertaseAssembly of membrane attack complex (MAC)
Turnberg and Botto, 2003
Microbial Evasion•Some microbes can evade complement-mediated damage.
Schneider, et al 2007
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