Part 2 Thyroid hormones and antithyroid drugs. A. Thyroid hormones.
The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary...
-
Upload
alisha-simpson -
Category
Documents
-
view
216 -
download
3
Transcript of The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary...
![Page 1: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/1.jpg)
The Chemical Basisof Life
![Page 2: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/2.jpg)
All living things need water.
WHY?• Universal solvent• Dissolves necessary nutrients• Used to produce enzymes and hormones Necessary for life processes• Can conduct electricity
![Page 3: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/3.jpg)
Water is the universal solvent.
Remember polarity-uneven charge distribution on a compound
electrons are shared ondifferent energy shells
electrons are shared unequally(someone’s a bully)
![Page 4: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/4.jpg)
Polarity is important to solubility-the abilityOf a solvent to dissolve a solute.
Ionic solutes: ionic solutes are made of ions- charged atoms—one negative, one positive
Water has a positive end and a negative endwhich will exert attractive forces on thesolute
![Page 5: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/5.jpg)
POLARITYUNEVEN DISTRIBUTION OF CHARGESMolecules tend to be asymmetric
__ +
On polar molecules, electrons are controlled by oneOf the atoms.
![Page 6: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/6.jpg)
Polarity – the uneven distribution of charges on a moleculeuneven distribution is a result of:
a. Sharing of electrons between atoms with different energy
1. Asymmetric molecules are polar
Electrons are veryPresent on this sideOf the molecule
That makes this sideOr pole of the moleculeFeel negative
This side or pole of theMolecule has no Electrons present.The charge of the nucleusIs felt making it feelpositive
Hydrogen has one electron on the K shellFluorine has 9 electrons on the K and L shells. Fluorine is a larger atom withMore energy. F controls all of the electrons.
![Page 7: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/7.jpg)
In the water molecule, hydrogen is a smaller atom with less energy than oxygen.When the electrons are share between these two atoms, oxygen controls the electrons because it is an atom with more energy.
Because of this the molecule has two poles – one that feels positive (hydrogen’s end) and the other that feels negative (oxygen’s end).
![Page 8: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/8.jpg)
Well how does all this connect with solutions? The reason why solutes stay in solutionis because of polarity. Polar solutes dissolve most easily in polar solvents – water is polarand so it can dissolve all polar molecules. Nonpolar solvents dissolve nonpolar solutes.
NaCl
NaCl is an ionic compoundthat is made up of + Naions and - Cl ions.NaClWhen an ionic compounddissolves in water it is called DISSOCIATION.
Na +Na +
Na +
Na +
Na + Na +
Na +Na +
Na +
Na +
Na +
Na +Na +
Na +
Na + Na +
Na +
Cl -
Cl -
Cl -
Cl -
Cl -
Cl -
Cl -
Cl -Cl -
Cl -
Cl -
Cl -
Cl -
Cl -
Cl -
Cl -
Cl - Cl -
Cl -Cl -
![Page 9: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/9.jpg)
Molecules can also be nonpolar – an even distribution of charge on the molecule. a. Sharing of electrons between atoms of equal energy
1. Diatoms
Here this diatom, electrons are on the same energy level. Electrons are on the sameenergy shells and therefore are controlled equally by each atom. Electrons spin equally around each nucleus.
![Page 10: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/10.jpg)
If a non polar molecule is put into water, it will NOT dissolve because of the like Charges that will meet in the water and the solute.
CH4 is a symmetricmolecule that is non polar. It will notdissolve in waterbecause it will be repelledby the positive pole ofthe water molecule.
![Page 11: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/11.jpg)
Solutions are special kinds of mixtures
Let’s review!!
Element – pure substance homogeneous throughout only one kind of matter present
Compound – pure substance homogenous throughout made from 2 or more elements chemical in nature
Mixture – can be homogeneous or heterogeneous made from 2 or more elements, compounds, or both physical in nature
![Page 12: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/12.jpg)
Special solutions
Suspensions• Made of solute/solvent• Heterogeneous • Solute is suspended in the solvent for a
period of time• Solute will eventually settle out of
solution• Oil and vinegar• Chocolate milk• Sand and water• Blood
Colloids• A special kind of suspension where
the solute is held in the solvent for an extended time period.• Homogeneous • The use of an emulsifier is needed
to keep the solute in suspension.• Mayonnaise• Whipped cream
![Page 13: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/13.jpg)
Acid base comparisonacid• Any aqueous solution that
releases Hydrogen ions in solution.• Generally, any compound
that contains Hydrogen• Will react with metals to
release Hydrogen gas.• Has a pH between 1 and 6.9• Tastes sour• Turns blue litmus red• Will react with a base to
produce a salt + water
base
• Any aqueous solution that releases hydroxyl ions (OH) in solution.• Generally, any compound
that contains the OH ion.• Has a pH between 7 and 14• Tastes bitter• Feels slippery• Turns pink litmus blue.• Will react with an acid to
product a salt + water.
![Page 14: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/14.jpg)
Acid: hydrochloric acid – HCl stomach acid sulfuric acid - H2SO4 car battery acid nitric acid HNO3 fertilizers carbonic acid H2CO3 acid found in sodas
Bases: sodium hydroxide – NaOH Drano human blood potassium hydroxide – KOH soaps calcium hydroxide – Ca(OH)2 hair relaxer, remover, Ca supplement in baby food.
Neutralization reaction: Acid + base = salt + water HCl + NaOH NaCl + HOH pH 2 pH 14 pH 7 pH 7
![Page 15: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/15.jpg)
Compounds come in two types:Inorganic-usually ionic
made of a metal and a nonmetal soluble in water high melting points
crystals and minerals generally referred to as salts
![Page 16: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/16.jpg)
Organic- always covalent contain C, H, O H:O 1:2
many compounds that change shape bonds are weaker than ionic but
are very stable.
![Page 17: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/17.jpg)
Reactions that produce organic compounds:1. polymerization production of large organic
compounds that are produced from smaller compounds.Monomer + monomer = polymerProteins and large carbohydrates are formed through polymerization.
![Page 18: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/18.jpg)
2. dehydration synthesis=when H and OHAre removed from two compounds to form aLarger molecule
glucose plus glucose = maltose + water C6H12O6 + C6H12O6 = C12H22O11 + H2ODehydration means: to take water out
![Page 19: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/19.jpg)
3. Hydrolysis reaction: a large molecule isBroken down to form 2 or more smallermolecules by adding water to the rxn.
Starch + water = smaller glucose molecules
![Page 20: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/20.jpg)
All reactions require a specific amount of energy to produceAn activated complex=unstable atoms. The least amount ofEnergy needed to produce this activated complex is theActivation energy.
Exothermic vs endothermic
![Page 21: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/21.jpg)
Catalysts work to supply more energy to a reaction therebyDecreasing the amount of energy needed to produce anActivated complex or specifically reducing the activationEnergy of the reaction. Catalyst make reaction proceed moreQuickly. Enzymes are called biological catalysts and work the sameWay as chemical catalysts within living organisms. Inhibitors work in the opposite way.
![Page 22: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/22.jpg)
How enzymes work:
Terms to remember: active site, substrate, enzyme-substrate complex,denaturation
![Page 23: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/23.jpg)
4 necessary organic compounds for life
1. Carbohydrates: C.H.O1. Monosaccharides - glucose2. Disaccharides - sucrose3. Polysaccharides – celluloseEnergy: immediate – simple long term – starch
stored – as fat
![Page 24: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/24.jpg)
Proteins:C, H, O, N, Samino acids = monomersenzymescell structurepeptide bondscellular repair, muscle formation, genes
![Page 25: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/25.jpg)
Lipids:C, H, Ofats, oils and waxes – cholesterolsaturated and unsaturatedsingle bonds double/triple bondsenergy: immediate and stored
![Page 26: The Chemical Basis of Life. All living things need water. WHY? Universal solvent Dissolves necessary nutrients Used to produce enzymes and hormones Necessary.](https://reader035.fdocuments.in/reader035/viewer/2022081603/56649e415503460f94b33ff4/html5/thumbnails/26.jpg)
Nucleic acids: C, H, O, NDNA, RNAnucleotides: sugar (ribose), nitrogen base,
phosphate group (-PO4)inheritance, cell function