The Center for Inflammation and Regenerative Modelingcbsg/Materials/GillesRTG.pdfRTG kick-off day...
Transcript of The Center for Inflammation and Regenerative Modelingcbsg/Materials/GillesRTG.pdfRTG kick-off day...
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RTG kick-off dayThe Center for Inflammation and
Regenerative Modeling
Gilles Clermont, Medical DirectorAssociate Professor of Critical Care Medicine,
Industrial Engineering and Mathematics, University of Pittsburgh)
www.mirm.pitt.edu/cirm
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Mathematical biology of acute inflammation
Hot! This will change the worldMultidisciplinarity
Mathematics, Medicine, Engineering, Computational Biology, CS, BioinformaticsUndergrads, Grad students, post-docsPitt, CMU
Close mentorshipScientific guidancePapers, grant writing (post-docs)Exposure (conference)
Employment
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Mathematical disciplines involved
DynamicsModel design and simulation
OptimizationLinear algebra, applied analysis, statistical mathematics, control, differential geometry, numerics
Machine-learning algorithms
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Computation
Numerical algorithmsDistributed and parallel computing
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Specific projects
Biological models of influenza A virusMultiscale (lung function/cells/pathways)Ermentrout/Swigon
Model-based therapy of uncontrolled inflammationSEPsIS project (Rubin)Vocal cord injury and healing (Swigon)Multiorgan failure (Ermentrout/Rubin)
Renal failureEpidemiology and models of acute pancreatitis
Medical decision supportModel-based bayesian inference (Rubin)Machine-learning inference
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The SEPsIS project
Animal (LPS, CLP model of sepsisAdjust hemoadsorption intervention to optimize outcome
Mathematical model of diseaseComputational tools
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The SEPsIS project