THE AUSTRALIA AND NEW ZEALAND CARDIOTHORACIC ORGAN TRANSPLANT REGISTRY
97
THE AUSTRALIA AND NEW ZEALAND CARDIOTHORACIC ORGAN TRANSPLANT REGISTRY SEVENTEENTH ANNUAL REPORT 1984 – 2012 ANZCOTR 2012
description
THE AUSTRALIA AND NEW ZEALAND CARDIOTHORACIC ORGAN TRANSPLANT REGISTRY. SEVENTEENTH ANNUAL REPORT 1984 – 2012. ANZCOTR 2012. NUMBER OF ALL TRANSPLANTS BY YEAR 1984 - 2012. ANZCOTR 2012. NUMBER OF ALL TRANSPLANTS* 1984 - 2012. ANZCOTR 2012. *Includes domino, heterotopic and retransplants. - PowerPoint PPT Presentation
Transcript of THE AUSTRALIA AND NEW ZEALAND CARDIOTHORACIC ORGAN TRANSPLANT REGISTRY
THE AUSTRALIA AND NEW ZEALAND CARDIOTHORACIC ORGAN TRANSPLANT REGISTRY
SEVENTEENTH ANNUAL REPORT
1984 – 2012
ANZCOTR 2012
NUMBER OF ALL TRANSPLANTS BY YEAR 1984 - 2012
020406080
100120140160180
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
HEARTS HEART-LUNG SINGLE LUNG B-L LUNG
ANZCOTR 2012
NUMBER OF ALL TRANSPLANTS* 1984 - 2012YEAR HEART HEART-LUNG SINGLE LUNG BILATERAL LUNG1984 14 0 0 01985 22 0 0 01986 34 1 0 01987 30 1 0 01988 56 2 0 01989 93 14 0 01990 103 12 5 01991 103 19 18 01992 115 18 27 31993 114 13 24 331994 104 13 26 441995 108 13 28 431996 103 7 32 421997 105 4 43 431998 82 4 38 501999 76 2 27 472000 70 2 28 732001 82 1 29 552002 82 9 29 702003 89 5 20 68 Grand Total all Transplants
2004 78 6 13 912005 89 6 10 792006 80 6 17 882007 68 6 8 782008 90 5 12 1122009 71 2 13 1152010 76 3 10 1232011 76 2 12 1582012 85 4 4 153
2298 180 473 1568 4519
ANZCOTR 2012*Includes domino, heterotopic and retransplants
ALL HEART TRANSPLANTS BY HOSPITAL 1984 - 2012
ANZCOTR 2012
St Vincents The Alfred Royal Perth Auckland Prince Charles Royal Childrens Year Totals1984 14 141985 22 221986 34 341987 28 2 301988 49 5 2 561989 50 30 8 5 931990 47 38 6 8 4 1031991 41 33 5 20 4 1031992 36 37 11 22 9 1151993 39 35 8 28 4 1141994 44 25 10 21 4 1041995 41 25 7 7 20 8 1081996 35 24 4 13 24 3 1031997 35 28 5 14 21 2 1051998 26 23 9 10 10 4 821999 19 25 8 10 11 3 762000 20 22 6 13 9 0 702001 17 30 7 15 8 5 822002 19 24 6 8 17 8 822003 14 24 11 22 16 2 892004 28 23 7 4 14 2 782005 26 22 12 13 13 3 892006 19 22 7 8 16 8 802007 18 21 5 9 13 2 682008 27 28 13 8 8 6 902009 19 18 7 11 10 6 712010 27 23 6 11 3 6 762011 24 17 9 11 10 5 762012 25 15 13 12 13 7 85
Totals 843 612 142 254 335 112 2298
HEART LUNG TRANSPLANTS BY HOSPITAL 1986 - 2012
St Vincents The Alfred Royal Perth Auckland Prince Charles Royal Childrens Year Totals1986 1 0 0 0 0 0 11987 1 0 0 0 0 0 11988 1 0 0 0 0 1 21989 11 0 0 0 0 3 141990 6 6 0 0 0 0 121991 5 13 0 0 0 1 191992 8 10 0 0 0 0 181993 6 5 0 0 0 2 131994 6 6 0 0 0 1 131995 9 4 0 0 0 0 131996 4 3 0 0 0 0 71997 3 1 0 0 0 0 41998 4 0 0 0 0 0 41999 0 1 0 0 1 0 22000 2 0 0 0 0 0 22001 0 1 0 0 0 0 12002 2 4 0 0 3 0 92003 1 2 0 0 2 0 52004 3 0 0 0 3 0 62005 1 0 1 0 4 0 62006 1 3 0 0 2 0 62007 3 0 1 0 2 0 62008 1 3 1 0 0 0 52009 0 0 0 0 2 0 22010 0 1 2 0 0 0 32011 0 1 0 0 1 0 22012 3 0 0 0 1 0 4Total 82 64 5 0 21 8 180
ANZCOTR 2012Prince Charles 2005 figure includes one retransplant
SINGLE LUNG TRANSPLANTS BY HOSPITAL 1990 - 2012
St Vincents The Alfred Royal Perth Auckland Prince Charles Royal Childrens Year Totals1990 3 2 0 0 0 0 51991 14 4 0 0 0 0 181992 19 8 0 0 0 0 271993 14 9 0 1 0 0 241994 10 14 0 2 0 0 261995 10 17 0 1 0 0 281996 9 18 0 2 3 0 321997 16 21 0 3 3 0 431998 10 25 0 3 0 0 381999 12 13 0 1 1 0 272000 7 16 0 3 2 0 282001 5 21 0 3 0 0 292002 3 20 0 3 3 0 292003 4 10 0 4 2 0 202004 0 10 1 0 2 0 132005 3 2 4 0 1 0 102006 2 9 3 1 2 0 172007 2 6 0 0 0 0 82008 3 4 4 0 1 0 122009 2 7 2 1 1 0 132010 1 7 0 0 2 0 102011 2 8 2 0 0 0 122012 0 2 2 0 0 0 4
Totals 151 253 18 28 23 0 473
ANZCOTR 2012
BILATERAL LUNG TRANSPLANTS BY HOSPITAL 1992 - 2012
St Vincents The Alfred Royal Perth Auckland Prince Charles Royal Childrens Year Totals1992 2 1 0 0 0 0 31993 14 19 0 0 0 0 331994 21 22 0 1 0 0 441995 18 23 0 2 0 0 431996 23 12 0 6 0 1 421997 13 20 0 1 8 1 431998 17 16 0 2 13 2 501999 13 20 0 6 7 1 472000 29 25 0 9 10 0 732001 28 18 0 8 1 0 552002 28 25 0 5 12 0 702003 28 25 0 10 5 0 682004 31 32 0 9 19 0 912005 28 27 2 8 14 0 792006 32 35 4 9 8 0 882007 25 29 6 9 9 0 782008 40 40 6 12 14 0 1122009 38 49 4 7 17 0 1152010 40 54 7 9 13 0 1232011 43 70 12 10 23 0 1582012 47 57 12 12 25 0 153Total 558 619 53 135 198 5 1568
ANZCOTR 2012Includes retransplants
COMBINED WAITING LIST ACTIVITY 2012
ANZCOTR 2012*Contains complete calendar year activity from all Registry Participant Centres. nb lungs column includes heart/lung procedures
HEARTS TOTAL LUNGS TOTAL
Active as at 1 January 2012 78 112
New Additions during 2012 108 186
From on hold to Active Jan 2012
Removals from Waiting List (Permanent)
W1 - Transplant Performed 85 161
W2 - Patients condition Improved 5 3
W3 - Too ill, new dev of contraindications etc 2 7
W4 - Patient declined 0 0
W5 - Transferred to another interstate list 1 0
W6 - Died waiting 8 14
W7-Removed - unspecified 6
TOTAL at Year end - (Active) 31 December 2012 78 107
Total at month end inactive - (On HOLD) 7 4
PRE TRANSPLANT DIAGNOSISHEART 1984 - 2012
ISCHAEMIC HEART DISEASE 36%
IDIOPATHIC DILATED CARDIOMYOPATHY 40%
Viral CM / Myocarditis 3%
Congenital HD 6%
Other 13%
Retransplant 1%
Peripartum CM 1%
ANZCOTR 2012
Familial CM 2%
PRE TRANSPLANT DIAGNOSIS 1984 - 2012 n = 2298
Pre Transplant Diagnosis (Hearts) Number %Idiopathic Cardiomyopathy (IDCM) 920 40%Ischaemic Heart Disease (IHD) 788 35%Other (eg. Valve disease, adriamycin toxicity,trauma) 306 13%Congenital Heart Disease 126 6%Viral Cardiomyopathy/Myocarditis 61 3%Familial Cardiomyopathy 54 2%Peripartum Cardiomyopathy 22 1%Retransplantation 21 1%Total 2298 100%
ANZCOTR 2012
PRE-TRANSPLANT STATUS HEARTS 1996 -2012
ANZCOTR 2012
0%
20%
40%
60%
80%
100%
96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
NYHA IIINYHA IVInotropic supportIntra-aortic Balloon Pump (IABP)Ventricular Assist Device (VAD+TAH)
PRE-TRANSPLANT STATUS HEARTS 1993 - 2012
ANZCOTR 2012
DONOR / RECIPIENT STATE OF ORIGIN HEARTS 1984 - 2012
0
100
200
300
400
500
600
700
ACT NT NSW QLD VIC SA WA TAS NZ
Recipients 1984-2012 Donors 1984-2012
Number
ANZCOTR 2012
DONOR / RECIPIENT STATE OF ORIGIN HEARTS 1984 - 2012
Location Recipients 84-12 % Donors 84 - 12 % Recipients 2012 % Donors 2012 %
ACT 40 1.7 48 2.1 0 0 1 1.2NT 5 0.2 19 0.8 0 0 2 2.4
NSW 688 30.1 592 26.2 25 30 17 20.2QLD 371 16.2 438 19.4 14 17 18 21.4VIC 570 24.9 491 21.7 14 17 13 15.5SA 103 4.5 204 9.0 3 4 8 9.5WA 177 7.7 151 6.7 13 15 9 10.7TAS 55 2.4 36 1.6 3 4 4 4.8NZ 278 12.2 281 12.4 12 14 12 14.3
TOTALS 2287 100.0 2260 100.0 84 100 84 100.0
ANZCOTR 2012
Mean Waiting Time to TransplantHEARTS 1984 - 2012
0
50
100
150
200
250
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
Mean Waiting Time in days
DAYS
YEAR
ANZCOTR 2012
WAITING DAYS TO HEART TRANSPLANT 1984-2012
Due to limitations in the software, values over 1000 , until 2012, are represented as 999)ANZCOTR 2012
year n mean std dev + - median min-max1984 14 44 77 10 4-2951985 19 46 54 19 3-2091986 32 67 76 37 3-2951987 30 61 80 40 3-4241988 56 80 102 33 1-4001989 93 86 87 61 1-4451990 103 99 154 35 1-8421991 103 103 126 57 1-6331992 115 87 119 51 1-7901993 114 116 127 78 1-6261994 104 192 219 128 1-999*1995 108 203 236 107 3-999*1996 103 171 200 92 2-999*1997 105 228 265 127 1-999*1998 82 185 219 117 1-999*1999 75 236 260 133 1-999*2000 70 196 227 120 1-999*2001 80 177 212 88 1-999*2002 82 148 219 64 1-999*2003 88 143 162 91 1-7822004 76 134 176 67 1-9082005 89 159 169 113 2-7922006 79 150 155 102 2-7642007 63 163 180 125 1-9742008 89 171 174 127 1-9762009 68 147 132 103 5-5652010 74 180 232 97 0-999*2011 76 171 165 115 1-5862012 84 202 213 139 2-1181
Mean Recipient Age at TransplantHEARTS 1984 -2012
0
10
20
30
40
50
84 86 88 90 92 94 96 98 0 2 4 6 8 10 12Year
Age(yrs)
ANZCOTR 2012
RECIPIENT AGE AT HEART TRANSPLANT YEARS 1984 - 2012
ANZCOTR 2012
year n mean std dev + - median min-max1984 14 33 15 39 11-511985 19 39 13 38 10-541986 32 40 13 43 11-571987 30 41 12 46 13-561988 56 41 14 45 4-631989 93 42 14 46 1-651990 103 43 15 47 6-651991 103 47 14 52 1-641992 115 45 15 51 4-661993 114 46 14 51 6-651994 104 47 13 50 1-661995 108 46 16 50 2-681996 103 48 13 53 10-641997 105 46 14 50 9-661998 82 46 15 51 1-641999 75 47 15 53 2-672000 70 49 13 53 12-662001 80 45 15 49 2-642002 82 45 18 52 7-702003 88 45 15 47 1-672004 76 47 15 52 9-662005 89 48 14 52 5-652006 79 43 17 49 3-672007 66 46 16 49 5-712008 89 46 17 50 6-672009 68 45 17 48 1-692010 74 47 16 52 5-702011 76 45 17 48 5-722012 84 42 16 47 1-67
Hearts Mean Donor Age 1984 - 2012
0
5
10
15
20
25
30
35
40
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
Year
Age in years
ANZCOTR 2012
DONOR AGE HEARTS - YEARS 1984-2012
ANZCOTR 2012
year n mean std dev +- median min-max1984 14 24 8 23 13-411985 19 24 7 21 15-431986 32 26 7 25 16-391987 30 25 7 24 14-411988 56 25 8 23 12-441989 93 28 11 26 1-501990 103 30 11 28 9-521991 103 30 12 28 5-581992 115 30 12 28 1-561993 114 34 13 32 8-611994 104 34 14 31 1-661995 108 32 14 33 2-591996 103 33 12 33 1-571997 105 35 13 35 12-581998 82 31 13 30 1-621999 75 34 16 32 1-642000 70 33 13 33 5-572001 80 33 14 33 6-582002 82 30 15 25 2-602003 88 35 14 36 8-622004 76 33 14 31 7-592005 89 37 14 39 9-612006 79 31 14 29 5-592007 66 34 15 35 10-592008 89 37 13 40 2-612009 68 33 14 34 5-622010 74 38 12 39 6-602011 76 34 14 33 5-582012 84 34 14 34 4-58
HEARTS - Mean Ischaemic Time 1984 - 2012
0
50
100
150
200
250
300
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
Minutes
YearANZCOTR 2012
MEAN HEART ISCHAEMIC TIME - MINUTES 1984-2012
ANZCOTR 2012
year n mean std dev +- median min-max1984 14 74 16 70 54-1081985 19 114 41 95 53-1831986 32 136 47 133 80-2351987 30 151 45 155 60-2601988 56 152 44 158 78-2401989 93 150 57 147 39-3111990 103 165 74 144 54-4411991 103 178 80 163 55-3901992 115 183 76 164 52-4201993 114 207 82 198 41-4461994 104 193 75 190 75-4451995 108 208 98 186 42-4651996 103 201 79 177 60-4051997 105 211 90 194 60-4541998 82 240 103 213 74-6121999 75 236 101 244 43-4472000 70 247 89 242 102-5162001 80 265 102 253 186-3382002 82 237 79 224 107-4432003 88 258 90 268 176-3232004 76 244 87 239 88-4272005 89 239 91 239 59-4912006 79 246 84 238 109-4132007 66 244 91 248 73-5102008 86 252 88 244 115-5402009 68 231 89 227 90-2542010 74 229 74 226 94-3902011 76 240 80 239 101-4722012 84 226 67 227 59-448
ACTUARIAL SURVIVAL - HEART TRANSPLANT 1984 - 2012
YEAR n* %0 2280 100.01 1929 86.92 1814 84.53 1701 82.34 1596 80.15 1488 78.06 1379 75.07 1256 72.28 1139 69.39 1027 66.0
10 920 63.111 828 60.512 722 57.313 659 55.414 579 52.315 501 49.216 421 45.517 358 43.218 299 40.319 237 38.020 189 36.221 137 34.522 102 32.023 70 30.524 41 29.525 23 27.726 14 24.827 7 24.828 4 24.829 1 24.8
n* = Number alive at start of year
ANZCOTR 2012
ACTUARIAL SURVIVAL - HEART TRANSPLANT 1984 - 2012
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Percent Survival
YEAR
ANZCOTR 2012Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL – ORTHOTOPIC v HETEROTOPIC v DOMINO TRANSPLANTS 1984 - 2012
Orthotopic Heterotopic DominoYEAR n % n % n %
0 2249 100.0 31 100.0 35 100.01 1915 87.2 22 70.1 27 79.72 1804 84.8 19 61.3 27 79.73 1689 82.7 18 58.1 26 76.84 1585 80.5 16 58.1 20 61.75 1478 78.3 13 54.2 20 61.76 1368 75.3 13 54.2 18 55.57 1245 72.5 13 54.2 17 52.58 1132 69.7 10 45.2 16 52.59 1025 66.5 8 40.2 14 45.9
10 920 63.5 8 40.2 14 45.911 827 60.9 5 40.2 14 45.912 721 57.7 3 40.2 12 39.313 661 55.8 2 26.8 12 39.314 581 52.7 12 39.315 507 49.6 12 39.316 424 45.9 11 36.117 364 43.7 11 36.118 303 40.7 10 32.819 242 38.4 6 25.520 193 36.7 6 25.521 138 34.8 4 25.522 105 32.323 72 30.224 42 29.125 25 27.426 15 24.827 8 24.828 4 24.829 2 24.8
ANZCOTR 2012
Actuarial Survival Orthotopic Hearts v Heterotopic Hearts 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Orthotopic Heterotopic Domino
Percent Survival
ANZCOTR 2012
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL ALL HEARTS PERIOD COMPARISON 1984 – 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
1984-89 1990-99 2000-09 2010-12
ANZCOTR 2012
Percent Survival
p<0.001
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HEARTS PERIOD COMPARISON 1984 - 2012
1984-1989 1990-1999 2000-2009 2010-2012Year n* % n* % n* % n* %
0 244 100.0 1012 100.0 790 100.0 234 100.01 213 87.3 871 86.1 695 88.0 150 86.92 202 82.8 847 83.7 678 85.8 87 85.43 198 81.1 819 80.9 665 84.2 19 85.44 196 80.3 788 77.9 611 82.55 191 78.3 760 75.1 534 80.96 185 75.8 725 71.6 469 79.07 176 72.1 688 68.0 392 78.38 167 68.4 654 64.6 317 77.09 158 64.8 621 61.4 248 74.310 145 59.4 595 58.8 180 72.211 139 57.0 568 56.1 121 70.812 132 54.1 535 52.9 55 69.213 127 52.0 517 50.9 15 67.314 117 48.0 462 48.515 107 43.9 394 46.016 97 39.8 324 42.817 94 38.5 264 40.418 87 35.7 212 37.819 84 34.4 153 35.220 80 32.8 109 33.621 75 30.7 62 32.422 69 28.3 33 30.423 65 26.6 5 30.424 41 25.725 23 24.126 14 21.627 7 21.628 4 21.629 1 21.6
ANZCOTR 2012*N = NUMBER ALIVE AT START OF YEAR
ACTUARIAL SURVIVAL PRE TRANSPLANT DIAGNOSIS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
IHD IDCM Others
Percent
ANZCOTR 2012
IDCM v IHD p<0.005
IHD v Others p<0.005
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL PRE TRANSPLANT DIAGNOSIS HEARTS 1984 – 2012Year IHD IDCM Others
n % n % n %0 787 100.0 925 100.0 568 100.01 658 84.3 797 89.0 474 87.22 623 81.2 743 86.3 448 86.13 596 79.5 693 83.9 413 83.74 565 77.2 647 81.1 386 82.75 532 74.7 606 79.3 350 80.56 494 71.2 562 76.6 323 77.97 452 67.6 512 74.4 292 75.48 413 64.6 458 70.6 268 74.69 370 60.3 424 69.2 233 69.710 334 57.1 382 66.7 205 66.311 296 54.4 355 64.9 177 62.612 253 50.1 314 62.4 155 60.413 226 48.2 296 60.6 137 57.914 195 45.3 262 57.4 122 54.915 173 42.7 224 54.4 104 50.716 142 38.3 197 51.7 82 46.517 117 34.9 169 50.0 72 45.318 95 32.4 145 47.8 59 40.119 74 28.4 115 46.0 48 40.120 56 26.3 94 44.3 40 39.221 37 24.7 72 42.2 28 36.922 28 22.5 56 39.0 19 35.423 18 19.7 41 38.2 11 33.124 6 18.2 25 37.1 10 33.125 1 13.6 15 35.3 7 33.126 1 13.6 9 32.5 4 27.627 1 13.6 4 32.5 2 27.628 2 32.5 2 27.629 1 27.6
ANZCOTR 2012
ACTUARIAL SURVIVAL PRE-TRANSPLANT STATUS HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
NYHA III NYHA IV INOTROPES IABP All VAD
ANZCOTR 2012
Percent
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
p=ns
ACTUARIAL SURVIVAL PRE-TRANSPLANT STATUS HEARTS 1984 - 2012
ANZCOTR 2012
NYHA III NYHA IV INOTROPES IABP All VADYear n= % n= % n= % n= % n= %
0 1146 100.0 565 100.0 250 100.0 50 100.0 234 100.01 984 87.4 479 86.3 219 88.7 42 86.0 191 88.92 940 85.3 457 83.2 212 87.1 42 86.0 160 84.43 882 82.7 442 81.7 201 85.0 41 84.0 133 82.74 825 80.1 428 80.6 192 83.3 38 77.8 111 79.45 766 77.7 413 79.3 182 81.1 37 75.8 88 75.56 707 74.7 395 77.1 164 76.1 35 71.7 74 72.87 656 72.0 354 73.9 150 72.8 35 71.7 57 70.68 596 68.4 329 72.0 142 70.3 33 69.6 37 69.19 551 66.0 292 67.5 127 66.3 30 67.5 25 62.7
10 497 63.4 262 63.7 116 64.1 27 63.2 19 57.311 443 60.9 241 61.2 105 62.4 23 56.3 16 54.112 385 58.6 215 57.1 90 58.1 22 53.9 11 46.613 347 56.7 199 55.2 83 55.5 21 51.4 8 46.614 296 53.3 180 52.3 76 52.7 19 49.0 7 46.615 256 50.1 155 49.0 68 50.6 17 44.0 7 46.616 210 46.2 134 45.7 55 45.9 17 44.0 5 39.517 177 44.3 115 42.2 48 44.1 17 44.0 3 39.518 139 41.0 101 39.9 41 40.3 16 41.4 3 39.519 96 38.3 89 37.5 35 38.3 12 41.4 2 39.520 73 36.6 75 35.3 30 38.3 9 38.4 2 39.521 46 34.8 58 32.7 25 38.3 8 34.622 38 34.8 42 29.0 17 34.8 5 30.323 20 32.5 32 26.7 14 34.8 3 25.224 14 32.5 20 26.7 5 28.2 3 25.225 7 29.5 12 26.7 3 28.2 3 16.826 5 29.5 6 21.4 2 28.2 2 16.827 2 29.5 4 21.4 1 16.828 1 29.5 2 21.4 1 16.8
ACTUARIAL SURVIVAL RECIPIENT AGE BY GENDER HEARTS 1984 - 2012
MALES 0-39 FEMALES 0 - 39 MALES >39 FEMALES > 39Year n= % n= % n= % n= %
0 434 100.0 219 100.0 1341 100.0 286 100.01 367 88.2 188 87.1 1137 86.6 239 86.52 344 85.8 181 86.7 1071 83.8 219 83.93 321 83.0 161 80.8 1020 82.2 201 83.54 307 82.0 148 78.2 955 79.3 189 83.15 285 79.8 136 77.1 894 76.9 174 81.36 266 77.8 124 73.6 832 73.7 158 78.47 244 76.6 107 69.9 761 70.6 144 75.38 219 73.3 100 69.9 694 67.2 127 74.29 195 69.5 93 67.1 629 64.0 111 70.610 176 67.3 83 64.1 564 61.0 98 66.611 160 65.7 73 60.1 512 58.4 86 63.812 142 63.2 67 59.3 444 55.0 70 59.113 135 62.7 59 55.6 400 52.8 65 57.314 123 61.3 55 53.7 348 49.3 54 53.615 112 60.2 48 50.7 292 45.3 49 52.616 94 56.8 41 49.5 246 41.1 41 49.217 84 55.6 36 48.3 204 38.3 36 47.918 74 51.5 33 45.5 166 35.3 28 47.919 64 50.0 27 45.5 124 32.5 22 44.220 53 49.2 25 45.5 98 30.0 15 44.221 38 47.1 18 43.5 69 28.2 13 41.222 32 47.1 16 41.0 47 25.0 9 37.623 23 45.4 10 41.0 31 23.8 6 25.124 16 43.1 6 41.0 15 22.8 4 25.125 11 40.0 5 31.9 4 20.5 3 25.126 7 40.0 3 31.9 4 20.527 3 40.0 1 31.9 3 20.528 2 40.0 1 31.9 1 20.5
ANZCOTR 2012*N= NUMBER ALIVE AT START OF YEAR
ACTUARIAL SURVIVAL BY RECIPIENT AGE AND GENDER HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
MALES 0-39 FEMALES 0-39 MALES >39 FEMALES > 39
ANZCOTR 2012
Percent Survival
MALES 0-39 yrsv MALES>39yrs p<0.005
MALES>39yrs v FEMALES>39yrs p <0.05
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL DONOR AGE HEARTS 1984 - 2012
0 - 16 17 - 39 40 - 49 50 -59 >59Year n= % n= % n= % n= % n= %
0 204 100.0 1306 100.0 495 100.0 259 100.0 16 100.01 177 90.0 1139 89.2 403 84.0 203 80.8 9 56.32 169 88.5 1085 87.2 377 81.5 176 75.9 7 43.83 160 85.3 1019 85.1 352 79.3 164 74.5 7 43.84 152 83.7 967 83.2 324 75.6 151 73.1 5 37.05 147 82.0 902 80.9 296 73.4 140 71.6 4 29.66 139 79.2 843 77.9 268 70.1 127 69.5 3 22.27 127 76.3 776 75.5 236 65.8 114 67.3 3 22.28 119 72.6 72 73.3 210 62.9 91 61.6 1 13.39 108 68.9 651 69.9 187 59.2 81 60.2 1 13.3
10 98 66.9 584 66.3 169 57.9 69 56.3 1 13.311 85 65.5 528 62.8 153 56.5 63 56.3 1 13.312 78 65.5 463 59.1 129 53.0 52 53.4 1 13.313 73 63.8 421 56.6 118 52.1 46 52.4 1 13.314 66 62.0 373 53.3 103 49.4 37 48.715 58 61.0 326 50.2 88 45.9 29 43.116 50 56.6 276 46.2 71 42.0 25 43.117 44 53.1 240 43.9 56 39.5 20 43.118 40 51.9 204 41.4 42 34.9 15 36.319 35 49.2 165 39.9 27 29.3 10 33.520 31 49.2 134 38.0 19 25.7 7 33.521 26 49.2 96 35.5 13 24.2 3 33.522 22 45.2 72 32.6 8 24.2 2 33.523 14 42.8 50 30.1 5 24.2 1 33.524 8 39.1 32 29.3 1 24.225 6 39.1 17 27.026 3 39.1 11 23.427 2 39.1 5 23.428 2 39.1 2 23.4
ANZCOTR 2012
*
* 2 OF THE 16 CASES IN THE GREATER THAN 59 YEARS CATEGORY ARE HETEROTOPIC HEART TRANSPLANTS
ACTUARIAL SURVIVAL DONOR AGE HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
0 - 16 17 - 39 40 - 49 50 -59 >59YEAR
Percent Survival
ANZCOTR 20122 OF THE 11 CASES IN THE GREATER THAN 59 YEARS CATEGORY ARE HETEROTOPIC HEART TRANSPLANTS
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
0-16yrs v 40-49yrs p<0.0010-16yrs v 50-59yrs p<0.00517-39yrs v 40-49yrs p<0.00117-39yrs v 50-59yrs p<0.009
ACTUARIAL SURVIVAL DONOR GENDER HEARTS 1984 - 2012
Female MaleYear n= % n= %
0 724 100.0 1554 100.01 582 83.3 1345 88.62 543 81.1 1269 86.03 503 78.8 1197 83.94 479 77.7 1117 81.25 442 75.9 1046 78.96 404 72.5 975 76.27 364 70.7 892 73.08 320 67.6 819 70.29 280 62.6 748 67.610 256 60.8 665 64.111 229 59.1 599 61.312 208 57.7 515 57.313 190 56.6 469 55.014 165 53.2 414 52.115 142 49.8 359 49.116 120 46.9 301 45.117 100 44.8 258 42.818 83 41.0 217 40.119 63 37.3 174 38.320 48 36.0 142 36.421 34 34.3 103 34.422 24 30.9 79 32.223 14 29.3 56 30.424 7 29.3 34 29.025 4 29.3 19 26.926 2 20.9 12 25.227 1 20.9 6 25.2
ANZCOTR 2012
ACTUARIAL SURVIVAL DONOR GENDER HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Female MaleYear
Percent Survival
ANZCOTR 2012
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL RECIPIENT GENDER HEARTS 1984 - 2012
Female MaleYear n= % n= %
0 505 100.0 1775 100.01 427 86.8 1502 87.02 399 85.1 1415 84.33 361 82.2 1341 82.44 336 80.8 1262 79.95 310 79.4 1179 77.66 282 76.2 1097 74.77 251 72.8 1005 72.08 226 72.2 913 68.69 204 69.0 824 65.310 181 65.5 740 62.511 159 62.1 669 60.112 137 59.2 586 56.813 124 56.6 535 55.014 109 53.7 470 52.015 97 51.7 404 48.616 82 49.4 339 44.617 72 48.1 286 42.118 61 46.7 239 38.919 49 45.0 188 36.420 40 45.0 150 34.321 31 42.6 106 32.522 25 39.6 78 30.123 16 34.2 54 29.224 10 34.2 31 27.925 8 34.2 15 25.526 3 23.7 11 25.527 1 23.7 6 25.5
ANZCOTR 2012
ACTUARIAL SURVIVAL RECIPIENT GENDER HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
Female MaleYear
Percent Survival
ANZCOTR 2012
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL ISCHAEMIC TIME HEARTS 1984 - 2012
<2hrs 2-4 hrs 4-6 hrs >6 hrsYear n= % n= % n= % n= %
0 336 100.0 1101 100.0 666 100.0 161 100.01 287 87.7 948 88.1 547 85.6 137 85.72 275 84.6 891 85.7 514 83.9 125 81.23 263 81.5 833 83.8 482 82.0 115 77.94 252 79.0 784 81.4 445 80.1 108 76.55 241 77.1 729 78.9 408 78.1 102 75.16 225 73.2 677 75.8 377 75.9 93 73.57 216 70.6 612 72.5 339 73.4 82 71.98 199 66.0 560 69.7 299 71.1 74 71.09 186 63.0 509 66.6 261 66.9 65 69.0
10 168 58.9 471 63.8 225 64.5 53 66.711 161 57.1 419 60.7 196 62.4 48 64.112 151 54.3 371 57.3 159 59.0 38 62.613 147 53.5 341 54.4 138 58.2 29 59.014 131 49.8 307 51.6 115 55.1 24 56.815 122 47.1 269 48.5 90 51.4 18 54.116 107 44.3 225 44.2 73 48.4 15 54.117 101 43.5 189 41.7 58 44.1 9 54.118 91 41.3 156 38.7 45 40.0 7 54.119 75 38.4 124 36.8 33 37.1 5 54.120 66 36.3 97 35.2 26 35.8 1 54.121 58 34.6 65 32.7 14 35.822 44 32.6 48 29.4 11 35.823 29 29.2 36 28.7 5 35.824 19 28.0 20 27.7 2 35.825 12 28.0 10 24.2 1 35.826 9 25.5 4 21.027 6 25.5 1 21.028 4 25.5
ANZCOTR 2012
ACTUARIAL SURVIVAL ISCHAEMIC TIME HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
<2hrs 2-4 hrs 4-6 hrs >6 hrs
ANZCOTR 2012
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL CROSSMATCH HEARTS 1984 - 2012Positive Negative
Year n= % n= %0 161 100.0 1961 100.01 123 79.2 1670 87.42 114 77.2 1580 84.93 104 73.7 1511 83.04 97 73.0 1436 80.75 89 72.2 1347 78.66 82 68.1 1252 75.67 74 63.9 1145 72.98 70 62.1 1045 69.99 64 57.7 952 66.810 56 54.0 859 63.911 51 52.0 775 61.412 45 47.8 676 58.313 42 47.8 616 56.214 41 47.8 537 52.915 36 45.4 465 49.716 28 41.3 393 46.017 25 38.3 334 43.818 25 38.3 276 40.619 17 31.7 220 38.720 13 31.7 178 36.821 8 28.8 129 34.922 7 28.8 96 32.223 6 28.8 64 30.324 3 28.8 38 29.125 1 28.8 22 27.226 1 28.8 13 24.327 7 24.3
ANZCOTR 2012
ACTUARIAL SURVIVAL CROSSMATCH HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
Positive NegativeYear
Percent Survival
ANZCOTR 2012
p < 0.01
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL PEAK PANEL REACTIVE ANTIBODIES ALL HEARTS 1984 - 2012
Year PRA<15% PRA≥15n= % n= %
0 2069 100.0 193 100.01 1760 87.1 163 85.72 1654 84.5 151 84.13 1557 82.5 141 80.94 1466 80.5 130 76.45 1363 78.3 124 74.66 1261 75.3 116 71.67 1147 72.7 104 67.48 1037 69.9 100 66.79 936 66.5 91 61.510 832 63.3 84 60.111 752 61.1 72 55.312 653 57.7 67 53.813 593 55.6 60 53.014 525 52.8 50 47.915 455 49.6 41 45.216 385 46.1 30 40.017 331 43.8 24 37.518 277 40.6 18 37.519 219 38.1 16 37.520 175 36.2 12 37.521 126 34.3 10 34.922 93 31.6 10 34.923 60 29.6 9 34.924 33 29.0 5 31.225 19 26.9 4 31.226 11 25.1 1 23.427 6 25.1 1 23.4 ANZCOTR 2012
ACTUARIAL SURVIVAL PEAK PRA ALL HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
PRA<15% PRA>=15%Year
Percent Survival
ANZCOTR 2012
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL CMV STATUS HEARTS 1984 - 2012
Donor Neg Rec Neg
Donor Pos Rec Neg
Recipient Pos
Year n= % n= % n= %0 356 100.0 401 100.0 1481 100.01 303 87.7 337 85.9 1261 87.32 285 85.4 313 82.8 1188 85.03 274 83.9 293 80.9 1112 82.94 256 81.1 281 79.2 1041 80.75 240 80.1 265 76.9 966 78.46 224 78.1 243 73.7 897 75.27 206 75.9 223 71.2 814 72.38 192 74.0 206 68.9 732 69.29 180 71.7 183 65.8 657 65.610 158 66.8 165 64.7 591 62.611 138 64.5 148 62.2 536 59.912 121 60.7 127 60.0 469 56.613 106 57.6 116 58.5 433 54.814 92 52.5 106 57.5 378 51.615 84 51.4 93 54.1 321 48.116 76 49.5 80 52.3 264 43.517 70 47.5 64 49.5 224 41.318 63 44.7 57 47.1 179 38.119 48 43.1 44 42.6 143 36.020 35 41.1 34 42.6 120 33.921 22 35.7 27 42.6 86 32.322 15 32.0 21 42.6 66 29.523 13 32.0 13 42.6 42 26.424 7 29.0 7 38.6 25 26.425 4 24.2 4 38.6 13 25.026 2 17.3 1 38.6 9 22.827 2 17.3 1 38.6 2 22.828 1 38.6 1 22.8
ANZCOTR 2012
ACTUARIAL SURVIVAL CMV STATUS HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
R-ve/D-ve R-ve/D+ve R+veYear
Percent Survival
ANZCOTR 2012
p=ns
R+ve = R+veD+ve or R+veD-ve
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HLA MISMATCH HEARTS 1984 - 2012
ANZCOTR 2012
Year MM0 MM1 MM2 MM3 MM4 MM5 MM6
n= % n= % n= % n= % n= % n= % n= %0 3 100.0 5 100.0 32 100.0 113 100.0 343 100.0 773 100.0 1011 100.01 3 100.0 4 100.0 26 81.3 97 90.0 288 85.6 670 89.4 843 85.32 2 66.7 3 100.0 26 81.3 94 89.1 270 83.8 626 86.9 794 82.43 1 33.3 3 100.0 26 81.3 91 87.2 254 83.1 589 84.5 739 80.04 3 100.0 24 81.3 89 87.2 235 81.1 562 82.6 686 77.15 3 66.7 23 77.9 85 84.2 217 78.3 520 81.0 641 75.06 2 66.7 23 77.9 77 82.2 201 74.6 486 78.1 591 72.07 2 66.7 21 74.4 71 78.9 180 72.3 445 74.5 537 69.78 2 66.7 20 70.9 66 77.8 163 66.6 409 71.9 480 67.49 1 66.7 18 67.2 58 75.3 150 62.9 378 68.4 423 64.410 1 66.7 16 67.2 53 72.6 131 59.0 341 64.9 379 62.011 1 66.7 15 63.0 51 71.3 118 55.8 303 61.7 343 60.112 1 66.7 14 58.8 48 68.4 111 54.3 264 58.9 285 55.913 1 66.7 12 54.5 44 68.4 104 52.9 237 56.6 261 53.914 1 66.7 11 49.9 39 66.8 95 49.8 209 53.7 225 50.615 1 66.7 10 49.9 34 65.0 79 44.9 179 50.5 198 48.116 1 66.7 8 39.9 30 63.0 66 41.3 150 46.9 167 44.317 1 66.7 7 39.9 26 58.7 58 38.7 128 44.9 140 42.018 1 66.7 5 39.9 24 56.4 49 37.3 103 40.1 120 39.819 1 66.7 4 39.9 19 56.4 38 37.3 82 36.8 94 37.020 1 66.7 4 39.9 16 56.4 27 33.0 65 35.3 78 35.721 1 66.7 4 39.9 10 52.2 20 31.6 50 35.3 53 32.122 4 39.9 4 45.2 15 29.8 38 32.3 43 30.823 2 39.9 2 45.2 12 27.7 24 29.3 30 29.1
24 8 25.1 15 29.3 16 27.925 5 25.1 10 29.3 8 25.726 3 19.5 6 29.3 6 22.227 1 19.5 4 29.3 2 22.2
ACTUARIAL SURVIVAL HLA MISMATCH HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
MM0 MM1 MM2 MM3 MM4 MM5 MM6Year
Percent Survival
ANZCOTR 2012
p<0.05
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HLA DR LOCUS MISMATCH HEARTS 1984 - 2012
Year MM0 MM1 MM2n= % n= % n= %
0 70 100.0 463 100.0 1747 100.01 58 86.9 399 89.5 1474 86.32 52 83.8 379 87.4 1384 83.73 48 78.9 361 86.2 1294 81.54 46 78.9 340 85.0 1213 78.95 44 77.1 313 82.2 1132 76.96 38 71.7 295 80.1 1047 73.87 35 69.8 271 77.8 950 70.88 33 69.8 248 74.0 859 68.19 30 65.5 225 70.4 773 65.0
10 27 65.5 201 66.5 693 62.111 25 63.0 184 63.8 622 59.612 23 58.0 164 60.2 536 56.613 21 55.4 152 59.1 486 54.414 20 52.7 132 55.5 428 51.515 18 52.7 115 52.8 368 48.116 15 46.7 98 48.1 309 44.817 14 46.7 86 45.6 260 42.518 12 43.3 70 41.6 219 40.019 11 43.3 52 40.3 174 37.220 9 43.3 43 37.8 139 25.621 7 43.3 33 36.8 98 33.322 5 30.9 26 36.8 73 30.623 3 30.9 16 33.5 51 28.724 2 30.9 10 31.0 29 28.025 6 31.0 17 26.826 4 25.4 10 24.927 4 25.4 3 24.928 2 25.4 2 24.929 2 24.9
ANZCOTR 2012
ACTUARIAL SURVIVAL HLA DR LOCUS MISMATCH HEARTS 1984 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
MM0 MM1 MM2Year
Percent Survival
ANZCOTR 2012
p= ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL MALIGNANCIES HEART 1984 - 2012
Year PTLD
OTHER MALIGNANCIES
(invasive skin/other)n= % n= %
0 95 100.0 430 100.01 88 92.6 422 98.12 86 90.5 414 96.53 81 87.3 410 95.64 73 79.7 396 92.85 70 77.5 381 90.06 65 73.1 363 86.47 57 64.1 346 82.68 55 62.9 325 78.59 50 58.3 302 74.4
10 44 52.4 279 70.411 39 47.6 259 66.312 36 44.0 237 62.413 36 44.0 227 60.814 31 40.2 203 57.315 28 36.3 179 53.216 23 32.3 149 46.817 17 26.4 122 42.218 12 21.4 102 38.619 10 17.9 72 33.620 8 16.0 55 31.121 5 16.0 40 26.822 5 16.0 32 24.023 3 16.0 21 20.624 1 16.0 13 20.625 1 16.0 7 20.626 4 17.2
ANZCOTR 2012*Survival of the group who were defined by having developed a malignancy
ACTUARIAL SURVIVAL MALIGNANCIES HEARTS 1984 - 2012
0102030405060708090
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
PTLD OTHER MALIGNANCIES
Year
Percent Survival
ANZCOTR 2012
ptld v other mal p=<0.005
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
RECIPIENT CAUSE OF DEATH - HEARTS1984 - 2012 n = 1038
0
50
100
150
200
250
300
TxCAD Misc Infection Acute Rejection
Other Malignancies
PTLD CVA Hemorrhage
No of Deaths
ANZCOTR 2012
19%
26%
14%
10%15%
4%
3%1%
NSGF
8%
CAUSE OF DEATH HEARTS 1984 - 2012 Transplant Coronary Artery Disease (TxCAD) 191Other Malignancy (non PTLD) 158Infection 142Acute Rejection 106Non-specific Graft Failure (NSGF) 82PTLD 41CVA 38Hemorrage 15
OTHER TOTAL(incl unspecified) 265Renal Failure 59Sudden Death 27Multi-organ Failure 27Cardiac Arrest/MI 26TxCAD + Rejection 12Heart Failure 14Pulmonary/Resp Failure 9Motor Vehicle Accident 6Suicide 7Non-compliance 6Pancreatitis 5
Total all Deaths = 1038 Right Ventricular Failure 4Liver Failure 5Pulmonary Hypertension 3Pulmonary Embolism 3Bowel Ischaemia 4Drug Overdose 2Aortic Dessection (Marfan's) 1
congenital bronchomalacia (1), pericarditis(1), peripheral vascular disease(3), anoxic brain/head inj(2)acute abdomen (2), myelodysplasia (1), esophogeal perforation (1)drug induced lung damage (1)esophageal diverticulum (1) COPD (3) Hepatic Encephalopathy (2) Gen. deterioration (3)amyloidosis (1), Parkinson's(1),mesenteric ischemia(1), died on table(2) aortic aneurism(2)Brain stem bleed (2), dissenting myopathy (1), stroke (2), Motor Neuron Disease (1)
Unspecified (data pending) 9
ANZCOTR 2012
CAUSE OF DEATH ALL HEARTS <5 YEARS AFTER TX 1984-2011
ANZCOTR 2011
No %
Infection 101 21
Misc (incl 0 no data) 77 16
Rejection 85 18
Non Specific Graft Failure 66 14
Graft Atherosclerosis (TxCAD) 56 12
Non Lymphoid Malignancy 30 7
Lymphoproliferative Disease 15 3
CVA 14 3
Haemorrhage 12 2
Graft Atherosclerosis & Rejection 8 2
Pulmonary Failure 5 1
Pulmonary Hypertension 2 1
Totals 471 100.0
CAUSE OF DEATH ALL HEARTS ≥5 YEARS AFTER TX 1984-2011
No %
Misc (incl 9 data pending) 147 29
Graft Atherosclerosis (TxCAD) 132 23
Non Lymphoid Malignancy 113 22
Infection 37 8
Lymphoproliferative Disease 27 6
Rejection 19 4
CVA 15 3
Non Specific Graft Failure 15 3
Pulmonary Failure 4 0.5
Haemorrhage 3 0.5
Graft Atherosclerosis & Rejection 4 0.5
Pulmonary Hypertension 1 0.5
Totals 527 100.0
ANZCOTR 2011
MALIGNANCIES* - HEART n = 529 1984 - 2012
PTLD 18 %
Other 82 %
ANZCOTR 2012
*the count of initial diagnosis only
MALIGNANCIES - HEART N=529 1984 - 2012PTLD 95 95/2280=4%Skin
Metastatic SCC 201 301/2280=13.2%Melanoma 26BCC 67Spindle Cell 2Merkle Cell 3Dermatofibrosarcoma 2
301
Other 133/2280=5.8%Lung 29Bowel 16Prostate 15Liver 10Renal 6Tonsil/throat/tongue 5Bladder 5Parotid 4Oesophagus 4Mesothelioma 4Cervix 3Thyroid/Parathyroid 3Breast 3Pancreas 3Carcinoid Tumour 1Ear/Face/Neck 1Brain 1Uterus 1Endometrium 1Leiomyosarcoma 1Leukaemia 1Liposarcoma 1Mediastinum 1Neuroblastoma 1Pituitary 1Seminoma 1Larynx 1Bone 1Caecum 1Testicle 1Unspecified 7 ANZCOTR 2012
Reason for Transplant Heart Lung 1986 - 2012
PPH 26%
Eisenmenger’s 21%
Other PH 3%
AAT deficiency 7%
Emphysema 3%
Congenital Heart Disease 14%
Cystic Fibrosis 14%
CFA 3%Bronchiectasis 2%
Misc 7%
ANZCOTR 2012
REASON FOR TRANSPLANT HEART LUNG n = 180 1986 - 2012
ANZCOTR 2012
Primary Pulmonary Hypertension 46 Eisenmenger's Syndrome 37 Congenital Heart Disease 26Cystic Fibrosis 25Alpha-1-Antitrypsin Deficiency 13Emphysema 6Cryptogenic Fibrosing Alveolitis 5Other Pulmonary Hypertension 5Bronchiectasis 4Miscellaneous 13
Total 180
Reason for Transplant Single Lung 1990 - 2012
AAT 16%
Emphysema 51%
IPF 25%
Misc 6%
Bronchiectasis 1%
Other PH / Eisenmengers / CF 1%
ANZCOTR 2012
REASON FOR TRANSPLANT SINGLE LUNG 1990 - 2012 n = 471
Emphysema 241Idiopathic Pulmonary Fibrosis 118Alpha-1-Antitrypsin Deficiency 74*Miscellaneous lung 29Bronchiectasis 5Other Pulmonary Hypertension 2Eisenmenger's Syndrome 1Cystic Fibrosis 1*Lymphangioleiomyomatosis(5), OB(4), PLAM(4), sarcoidosis(3),
pulmonary eosinophillic granulomatosis(2), allergic alveolitis(2), tuberous sclerosis(2),
severe air f low obstruction(1), Histiocytosis X(2), alveolar cell sarcoma(1), asthma(1),
Agammaglobulinaemia(1), hypersensitive pneuminitis(1)
ANZCOTR 2012
Reason for TransplantBilateral Lung 1992 - 2012
Cystic Fibrosis 35%
Emphysema 26%
IPF 9%
Bronchiectasis 8%
Misc 9% AAT 7%Other PH 1%
PPH 4%
ANZCOTR 2012
Eisenmengers 1%
REASON FOR TRANSPLANT BILATERAL LUNG 1992 - 2012 n = 1531
Cystic Fibrosis 525Emphysema 397Idiopathic Pulmonary Fibrosis(+ILD) 141Bronchiectasis 128Alpha-1-Antitrypsin Deficiency 112Primary Pulmonary Hypertension 62Other Pulmonary Hypertension 17Eisenmengers Syndrome 10*Miscellaneous lung 139* ILD(38), OB(22), sarcoidosis(23), PLAM (21), histiocytosis X(7), asthma (6), alveolitis(5), 1531eosinophilic granulomatosis(3), ARDS(3), silicosis(1), diffuse alveolar damage(2),
cystic lung disease (1), x -linked hypogammaglobulinemia(2), graft v host(1),
viral pneumonia(1), Wegeners granulomatosis(1), surficant c deficiency(1),
alveolar proteinosis(1), microlithiasis(1), pulmonary veno occlusive disease(1),
pulmonary capillary hemangiomatosis (1)
ANZCOTR 2012
Donor / Recipient State of Origin All Lungs 1986 - 2012
0100200300400500600700
Recipients 86 - 12 Donors 86 - 12
ANZCOTR 2012
Number
*Retransplants and unknown state of origins are not included
DONOR / RECIPIENT STATE OF ORIGIN ALL LUNGS 1986 - 2012
Location Recipients 86-11 % Donors 86-11 % Recipients 11 % Donors 11 %
ACT 22 1.0 51 2.3 2 1.3 2 1.3NT 4 0.2 27 1.2 0 0.0 5 3.2
NSW 647 29.8 579 26.6 45 28.7 33 21.0QLD 290 13.4 336 15.4 26 16.6 27 17.2VIC 629 29.0 538 24.7 42 26.8 41 26.1SA 152 7.0 214 9.8 12 7.6 14 8.9WA 180 8.3 151 6.9 14 8.9 11 7.0TAS 80 3.7 53 2.4 4 2.5 11 7.0NZ 167 7.7 229 10.5 12 7.6 13 8.3
Norfolk Isl 1 0.0 0 0 0 0.0 0 0.0
Total 2172 100.0 2178 100.0 157 100.0 157 100.0
ANZCOTR 2012*Retransplants and unknown state of origins are not included
Mean Wait to Transplant All Lungs 1990 - 2012
0
50
100
150
200
250
300
90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
mean wait in days
Days
Year
ANZCOTR 2012
MEAN WAITING TIME TO LUNG
TRANSPLANT – DAYS 1990 - 2012year n mean std dev median min-max1990 17 194 168 136 2-5001991 37 273 234 202 5-999*1992 48 209 217 148 1-999*1993 70 211 259 119 7-999*1994 83 272 239 201 8-999*1995 84 297 295 165 8-999*1996 81 205 205 132 7-999*1997 90 260 251 166 6-999*1998 92 215 178 186 1-999*1999 76 242 204 195 7-9392000 103 197 199 135 1-9002001 85 241 231 169 1-999*2002 108 226 215 161 7-999*2003 91 221 217 163 3-999*2004 109 285 256 197 4-999*2005 92 211 239 130 5-999*2006 108 188 221 119 0-999*2007 87 192 195 130 6-999*2008 120 228 244 130 1-999*2009 125 234 261 125 1-999*2010 130 221 216 149 0-999*2011 166 197 225 108 1-999*2012 156 186 216 120 0-1195
A total of 50 patients waited longer than 1000 days and were included in the above analysis as 999 days (due to limitations in the software)
ANZCOTR 2012
Mean Recipient Age at Transplant LUNGS 1989 - 2012
0
10
20
30
40
50
60
70
89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
HLTx SLTx BSLTx
ANZCOTR 2012
Age in Years
MEAN RECIPIENT AGE AT LUNG TRANSPLANT 1989 - 2012
HLTx SLTx BSLTxyear n mean std dev min-max year n mean std dev min-max year n mean std dev min-max1989 32 12 11-46 1989 19891990 37 10 20-51 1990 48 5 42-55 19901991 34 11 19-46 1991 46 8 32-57 19911992 31 12 15-49 1992 46 7 26-57 1992 3 34 17 19-521993 31 13 12-48 1993 51 3 46-57 1993 33 34 13 19-561994 32 10 14-46 1994 49 6 30-57 1994 44 36 10 19-541995 38 11 24-52 1995 51 7 22-59 1995 43 35 13 16-601996 26 6 18-37 1996 54 6 30-60 1996 42 39 14 13-601997 36 9 23-42 1997 51 6 35-62 1997 43 37 14 14-611998 4 26 14 13-43 1998 38 51 9 30-65 1998 50 38 14 14-601999 2 38 na 22-53 1999 27 55 7 37-64 1999 47 36 13 15-622000 2 34 na 22-46 2000 28 55 6 39-65 2000 73 40 13 14-632001 1 40 na 40 2001 29 56 9 32-69 2001 55 38 14 13-602002 9 35 10 22-49 2002 29 57 5 43-66 2002 70 39 14 14-652003 5 36 18 13-55 2003 21 57 7 42-66 2003 65 41 15 17-642004 6 36 10 21-47 2004 13 56 6 48-64 2004 90 44 14 15-652005 5 37 8 25-46 2005 10 61 3 57-66 2005 77 44 14 16-642006 6 25 14 9-45 2006 17 54 7 34-60 2006 85 45 16 15-662007 6 38 12 15-48 2007 8 57 5 50-64 2007 73 45 15 9-632008 5 36 9 25-45 2008 11 60 4 54-68 2008 106 44 15 15-692009 2 30 na 29-31 2009 12 58 14 14-67 2009 111 46 15 11-642010 3 37 18 17-51 2010 10 58 6 42-64 2010 117 45 16 11-692011 2 54 na 50-57 2011 12 59 5 53-68 2011 152 47 16 7-692012 4 25 9 18-37 2012 3 57 9 47-63 2012 149 47 15 12-69
ANZCOTR 2012
Mean Donor Age at Transplant ALL LUNGS 1989 - 2012
0
10
20
30
40
50
60
89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
HLTx SLTx BSLTx
ANZCOTR 2012
Years of Age
MEAN DONOR AGE AT TRANSPLANT LUNGS 1989 - 2012HLTx SLTx BSLTxyear n mean std dev min-max year n mean std dev min-max year n mean std dev min-max1989 14 23 11 11-43 1989 19891990 12 25 10 12-47 1990 5 32 12 18-49 19901991 19 29 7 17-43 1991 18 30 11 15-53 19911992 18 26 11 11-44 1992 27 34 9 18-50 1992 3 21 3 18-241993 13 27 14 10-55 1993 24 32 12 14-55 1993 33 31 13 15-551994 13 33 13 15-53 1994 26 29 9 17-50 1994 44 33 13 12-551995 13 33 13 10-50 1995 28 33 12 18-56 1995 43 33 12 9-581996 7 32 16 14-49 1996 32 38 12 14-54 1996 42 34 12 10-601997 4 31 13 17-45 1997 43 37 13 12-56 1997 43 33 14 12-551998 4 32 15 16-51 1998 38 35 13 16-58 1998 50 35 13 10-621999 2 53 na 51-55 1999 27 37 17 15-62 1999 47 40 14 14-592000 2 21 na 15-26 2000 28 41 17 17-66 2000 73 38 13 11-612001 1 50 na 50-50 2001 29 35 13 16-53 2001 55 33 15 10-592002 9 37 12 18-50 2002 29 35 13 12-62 2002 70 36 16 7-642003 5 35 16 8-49 2003 21 40 15 18-61 2003 65 35 14 8-622004 6 37 16 12-52 2004 13 33 13 19-56 2004 88 36 15 7-642005 5 33 18 11-58 2005 10 32 14 13-47 2005 77 40 13 9-642006 6 20 16 7-48 2006 17 41 18 13-64 2006 85 35 15 11-622007 6 28 16 13-50 2007 8 47 19 17-61 2007 73 37 15 10-622008 5 39 18 17-58 2008 11 40 12 19-56 2008 106 38 15 9-672009 2 33 na 15-50 2009 12 34 19 16-62 2009 111 39 16 15-652010 3 37 18 17-51 2010 10 58 6 42-64 2010 117 42 15 5-702011 2 53 na 46-60 2011 12 59 5 53-68 2011 149 43 17 8-722012 4 34 11 23-43 2012 3 21 3 18-23 2012 150 44 16 11-73
ANZCOTR 2012
LUNGS MEAN ISCHAEMIC TIME 1989 - 2012
0
100
200
300
400
500
89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12
SLTx BSLTx HLTx
ANZCOTR 2012
Minutes
LUNGS - MEAN ISCHAEMIC TIME 1989 - 2012 MINUTES
HLTx SLTx BSLTxyear mean std dev min-max mean std dev min-max mean std dev min-max1989 144 40 99-2071990 230 103 103-408 238 47 180-3101991 264 144 98-705 226 108 18-4501992 274 100 107-419 282 107 103-455 425 52 390-4851993 258 89 167-413 315 124 155-543 420 85 221-5681994 257 99 137-500 280 109 110-465 382 127 195-6551995 211 61 130-310 304 94 144-485 362 117 180-6001996 279 116 188-496 276 123 105-515 342 127 157-6561997 270 146 144-472 290 117 110-525 361 135 100-6751998 205 50 144-251 332 141 97-740 379 123 160-6231999 366 na 350-381 306 111 138-560 346 108 121-5792000 355 na 199-510 346 153 93-612 357 123 144-6552001 455 na 455-455 351 133 117-623 383 122 198-8152002 337 108 186-456 335 128 99-564 367 125 156-8502003 293 146 118-460 344 123 122-510 377 112 185-6352004 315 115 168-448 331 193 155-735 324 109 150-7352005 281 174 112-509 304 111 141-452 327 84 131-5402006 278 105 161-402 304 146 120-532 327 104 95-6252007 231 49 176-308 292 146 140-570 342 121 127-6092008 257 104 140-402 286 91 185-423 335 115 129-8802009 137 na 109-164 311 116 145-535 326 114 119-6352010 289 115 207-420 280 111 150-450 325 91 160-5772011 208 na 177-238 247 85 144-385 338 97 128-6572012 234 76 125-289 213 77 134-287 320 108 124-622
ANZCOTR 2012
Recipient Gender % Lung Transplants 1986 - 2012
474944
56
5153
0
10
20
30
40
50
60
70
Bilateral Lung Single Lung Heart Lung
Male Female
%
ANZCOTR 2012
Recipient Gender Lung Transplants 1986 - 2012
Transplant Type Male no % Female no %
Bilateral Lung 783 51 749 49
Single Lung 262 56 209 44
Heart Lung 85 47 94 53
ANZCOTR 2012
ACTUARIAL SURVIVAL ALL LUNGS 1986 - 2012
Year HLTx SLTx BSLTxn= % n= % n= %
0 179 100.0 471 100.0 1531 100.01 141 80.3 385 82.1 1261 88.32 122 70.0 332 72.8 1009 79.73 108 62.5 277 62.4 809 72.54 96 56.1 232 54.2 667 66.85 85 51.4 200 48.0 544 61.56 80 49.5 171 41.3 463 57.57 72 47.6 149 38.0 391 54.58 60 43.5 125 33.1 328 50.89 58 42.7 108 29.6 265 47.3
10 54 42.0 85 25.3 201 44.211 48 39.6 64 21.9 153 41.312 44 37.9 51 19.7 113 36.913 42 36.2 37 16.4 89 35.814 38 33.6 28 14.5 66 33.615 33 30.8 24 12.9 48 31.816 30 29.9 18 10.7 28 29.417 27 28.8 12 9.3 21 28.218 24 27.7 6 8.4 12 25.019 21 27.7 5 8.4 4 25.020 15 26.2 3 8.421 8 26.2 2 8.422 6 26.223 4 26.2
ANZCOTR 2012
ACTUARIAL SURVIVAL ALL LUNG TRANSPLANTS 1986 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
HLTx SLTx BSLTxYear
Percent Survival
ANZCOTR 2012
SL v HL p<0.005
SL v BL p<0.005
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL BILATERAL DCD DONORS V NON DCD DONORS 2006 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7
DCD Donors NON DCD DonorsYear
Percent Survival
ANZCOTR 2012
p<0.05
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL BILATERAL DCD DONORS v NON DCD BILATERAL DONORS 2006 - 2012
Year DCD ONLY NON DCD
n= % n= %
0 105 100.0 784 100.01 80 90.7 628 89.42 52 82.8 461 82.23 28 78.8 321 75.34 10 70.9 225 69.5
5 7 70.9 130 63.5
6 2 70.9 79 59.47 17 59.4
ANZCOTR 2012
ACTUARIAL SURVIVAL DONOR AGE ALL LUNGS 1986 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
0-16 17 - 39 40 - 49 > 49YEAR
Percent Survival
ANZCOTR 2012
0-16 yrs vs 40-49yrs p<0.05
17-39yrs vs 40-49yrs p<0.05
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL DONOR AGE ALL LUNGS 1986 – 2012 0-16 17 - 39 40 - 49 50+
Year n= % n= % n= % n= %0 169 100.0 992 100.0 491 100.0 529 100.01 142 86.8 827 86.5 402 86.4 417 85.72 120 79.8 710 78.0 330 76.6 308 76.13 104 74.3 596 70.5 255 65.5 241 68.74 87 66.9 506 64.5 215 59.6 189 60.65 74 61.3 436 59.6 172 53.7 148 53.86 66 58.8 380 54.7 147 48.9 125 49.37 57 56.0 331 51.6 122 45.8 102 46.78 45 48.8 287 47.4 98 42.2 84 42.99 41 47.6 240 43.0 85 40.4 67 40.7
10 34 42.8 187 39.7 67 35.8 54 39.311 29 41.5 148 36.1 56 34.1 35 34.412 22 39.9 117 32.2 42 32.1 27 30.213 18 39.9 96 30.1 34 28.9 21 27.814 14 37.5 84 28.2 23 26.0 13 24.715 12 37.5 67 26.4 15 21.1 11 24.716 7 33.7 51 24.2 10 17.9 8 24.717 7 33.7 42 22.7 6 17.9 7 21.618 6 33.7 30 21.5 4 17.9 2 13.819 4 33.7 21 21.5 3 17.9 2 13.820 2 33.7 14 20.3 2 17.9 1 13.821 2 33.7 6 20.3 1 17.922 2 33.7 4 20.323 3 20.3
ANZCOTR 2012
ACTUARIAL SURVIVAL ISCHAEMIC TIME ALL LUNGS 1986 - 2012
<2hrs 2-4 hrs 4-6 hrs >6 hrsYear n= % n= % n= % n= %
0 32 100.0 493 100.0 839 100.0 723 100.01 27 84.4 406 87.3 697 88.4 585 83.82 25 78.1 345 79.7 554 78.2 480 74.93 21 65.6 275 70.3 451 71.0 391 66.64 19 59.4 236 65.0 365 64.0 326 59.45 13 46.2 198 59.5 288 57.3 288 56.06 12 42.6 181 56.8 248 52.6 244 51.27 9 32.0 151 53.5 209 50.1 213 48.18 9 32.0 125 46.9 171 46.3 185 44.69 9 32.0 102 42.6 145 42.7 162 41.9
10 8 28.4 86 39.1 117 41.1 123 37.211 7 24.9 68 37.6 93 38.1 92 32.612 6 24.9 57 34.2 66 33.5 72 30.013 5 20.7 48 31.7 54 30.9 57 28.614 4 16.6 39 28.2 39 29.6 48 26.515 4 16.6 30 25.1 30 28.7 39 24.216 3 16.6 26 24.2 20 25.5 25 21.317 3 16.6 25 24.2 16 22.8 16 19.318 2 16.6 20 23.2 9 19.4 11 18.019 2 16.6 15 23.2 6 19.4 7 18.020 2 16.6 10 23.2 5 16.2 2 18.021 1 16.6 5 23.2 3 16.2 1 18.022 1 16.6 3 23.2 2 16.2
ANZCOTR 2012
ACTUARIAL SURVIVAL ISCHAEMIC TIME ALL LUNGS 1986 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
<2hrs 2-4 hrs 4-6 hrs >6 hrsYear
Percent Survival
ANZCOTR 2012
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL CROSSMATCH ALL LUNGS 1986 - 2012
Positive NegativeYear n= % n= %
0 135 100.0 1771 100.01 115 85.9 1459 86.22 95 78.1 1210 77.23 72 65.2 1013 69.34 61 59.6 857 62.85 54 56.5 715 57.06 49 52.3 621 52.27 46 50.2 543 49.08 38 43.5 461 44.99 32 38.8 288 41.710 25 36.1 303 38.311 19 31.5 239 35.312 15 26.4 189 32.113 13 26.4 155 29.814 10 22.2 122 27.715 10 22.2 94 25.516 8 22.2 67 23.117 6 22.8 54 21.618 4 22.2 37 19.819 4 22.2 25 19.820 2 15.8 16 19.821 1 15.8 8 19.822 1 15.8 5 19.823 3 19.8
ANZCOTR 2012
ACTUARIAL SURVIVAL CROSSMATCH LUNGS 1986 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Positive NegativeYear
Percent Survival
ANZCOTR 2012
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL CMV STATUS ALL LUNGS 1986 - 2012
YearDonor Neg Rec Neg
Donor Pos Rec Neg
Recipient Pos
n= % n= % n= %0 345 100.0 415 100.0 1376 100.01 282 86.3 256 89.7 116 85.52 242 79.7 285 78.9 909 76.83 209 72.9 239 72.5 725 67.94 172 66.0 202 65.3 603 61.75 145 61.6 174 60.6 496 55.76 118 55.3 152 56.0 433 51.47 97 51.8 134 52.9 368 48.48 79 47.9 109 47.2 315 44.79 72 45.4 90 43.5 260 41.310 58 40.8 68 40.3 205 38.111 46 37.7 54 37.2 158 34.612 36 34.2 45 35.7 119 30.913 29 32.2 35 32.3 98 29.214 23 32.2 29 29.4 75 26.615 16 30.6 25 28.3 60 24.716 11 28.4 13 22.9 48 23.417 11 28.4 9 20.9 38 22.318 8 25.6 7 20.9 24 20.319 5 25.6 6 20.9 17 20.320 4 25.6 1 20.9 12 18.921 2 25.6 1 20.9 5 18.922 2 25.6 2 18.9
ANZCOTR 2012
ACTUARIAL SURVIVAL CMV STATUS LUNGS 1986 - 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
R-ve/D-ve R-ve/D+ve R+ve
ANZCOTR 2012
Percent Survival
Years
R-D+ vs R+ p<0.05
R+ve = R+ve/D+ve or R+ve/D-ve
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HLA MISMATCH ALL LUNGS 1986 - 2012
ANZCOTR 2012
Year MM0-1 MM2 MM3 MM4 MM5 MM6n= % n= % n= % n= % n= % n= %
0 14 100.0 26 100.0 105 100.0 313 100.0 708 100.0 1015 100.01 12 85.7 21 80.8 92 91.3 262 87.6 563 84.5 838 86.82 9 70.8 16 68.7 80 85.1 211 79.1 464 76.5 688 77.03 8 70.8 14 68.7 65 77.3 170 69.4 376 68.9 563 68.64 4 50.6 10 58.1 60 76.0 135 59.7 310 61.1 478 63.75 4 50.6 10 58.1 54 73.4 111 54.1 260 57.0 391 56.86 4 50.6 8 46.5 47 67.8 98 51.1 223 52.2 338 52.07 2 50.6 8 46.5 37 63.2 87 48.4 182 48.5 296 49.48 2 50.6 7 40.7 30 59.5 72 42.7 158 44.1 245 45.79 2 50.6 7 40.7 27 55.5 59 36.6 145 41.6 193 42.9
10 1 50.6 6 40.7 25 53.4 53 34.7 114 37.3 143 39.511 1 50.6 6 40.7 22 47.0 44 31.3 85 34.1 110 36.812 1 50.6 6 40.7 17 40.3 38 29.8 66 31.5 80 32.413 1 50.6 6 40.7 14 35.4 33 29.0 55 30.5 60 28.914 1 50.6 3 32.5 12 32.8 26 26.2 45 28.7 47 26.815 1 50.6 2 32.5 9 32.8 18 23.9 39 28.0 36 23.216 1 50.6 2 32.5 7 32.8 12 20.9 27 24.8 27 21.817 1 50.6 5 32.8 10 20.9 21 21.9 25 21.818 1 50.6 3 32.8 6 20.9 15 21.9 17 18.019 1 50.6 3 32.8 4 20.9 11 21.9 11 18.020 1 50.6 2 32.8 2 20.9 5 19.3 9 18.021 1 50.6 1 20.9 3 19.3 5 18.022 1 50.6 1 20.9 1 19.3 3 18.023 1 50.6
ACTUARIAL SURVIVAL HLA MISMATCH ALL LUNGS 1986 – 2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
MM0-1 MM2 MM3 MM4 MM5 MM6
ANZCOTR 2012
Years
Percent Survival
MM0-1 v MM5 p<0.05MM0-1 v MM6 p<0.05
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HLA DR LOCUS MISMATCH ALL LUNGS 1986 -2012
0
20
40
60
80
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
MM0 MM1 MM2
ANZCOTR 2012
Percent Survival
Years
p=ns
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HLA DR LOCUS MISMATCH LUNGS 1986 – 2012
MM0 MM1 MM2Year n= % n= % n= %
0 59 100.0 449 100.0 1673 100.01 51 86.4 366 85.6 1371 86.52 43 77.7 298 77.8 1127 77.33 40 75.9 239 70.1 917 68.84 31 67.8 195 61.3 771 62.95 29 65.5 162 57.0 639 57.06 27 61.0 139 53.7 552 52.07 21 53.8 112 49.6 479 49.58 17 46.0 92 44.1 405 45.79 15 40.6 82 40.6 336 42.6
10 14 40.6 65 37.0 263 39.211 14 40.6 58 36.4 196 35.112 13 37.7 48 33.7 147 31.613 13 37.7 40 31.5 116 29.314 8 31.1 29 26.4 97 28.215 7 31.1 21 24.4 77 26.116 6 26.7 18 23.2 52 23.717 4 21.8 13 21.7 45 22.818 3 21.8 10 21.7 29 20.419 3 21.8 6 21.7 21 20.420 2 21.8 3 17.4 14 20.421 1 21.8 9 20.422 1 21.8 5 20.423 1 20.4
ANZCOTR 2012
CAUSE OF DEATH - ALL LUNGS 1986 - 2012
ANZCOTR 2012
CAUSE OF DEATH - LUNGS 1986 - 2012 n = 1133Bronchiolitis Obliterans 384 34%
Infection 246 22%
Pulmonary Failure 93 8%
Other Malignancy 70 6%
NSGF 56 5%
Acute Rejection 32 3%
Renal Failure 33 3%
Hemorrage 32 3%
PTLD 26 2%
CVA 24 2%
TxCAD 6 1%
OTHER (incl unspec) 131 11%
Totals 1133 100%Multi-organ Failure 27Cardiac Arrest (16) Heart Failure(5) IHD(4) 25Sudden Death (cause unknown) 12Post Surgical Complications 11Suicide(3) Non compliance(4) Withdrawal of treatment(2) Inanition(1) 8Bowel Ischemia(4) Perforation(1) Rupture(1) 6Liver Failure(5) Cirrhosis(1) 6Necrotising Bronchiolitis(3) BronchO Pneumonia(2) 5Pulmonary Embolism (4) 4Aspergillosis (3) Aspiration (1) 4Pancreatitis 4Hypoxic brain (2) 2Pneumothorax(1) 1Aortic Dissection 1Esophageal rupture 1Systemic vasculitis 1Parkinson's disease 1Metabolic problem 1Reperfusion Injury 1Dissecting Abdominal Aortic Aneurysm 1Cyclosporin Neurotoxicity 1Metabolic problem 1Unspecified (no data) 14
ANZCOTR 2012
CAUSE OF DEATH ALL LUNGS < 5 YEARS POST TX
No %Bronchiolitis Obliterans 126 42.0
Misc 37 12.3Infection 51 17.0
Non Lymphoid Malignancy 44 14.7Pulmonary Failure 24 8.0
Renal Failure 19 6.3No Data 4 1.3
PTLD 5 1.7Rejection 4 1.3
Hemorrhage 5 1.7CVA 1 0.3
Graft Atherosclerosis (TxCAD) 1 0.3
Totals 321 100.0
CAUSE OF DEATH ALL LUNGS ≥ 5 YEARS POST TX
No %Bronchiolitis Obliterans 258 34.4
Infection 195 26.0Misc 82 10.9
Pulmonary Failure 69 9.2Non specific Graft Failure 55 7.3
Rejection 28 3.7Haemorrhage 27 3.6
Non Lymphoid Malignancy 26 3.5PTLD 20 2.7CVA 23 3.1
Renal Failure 14 1.9Graft Atherosclerosis (TxCAD) 5 0.7
No Data 10 1.3
Totals 812 100.0
ANZCOTR 2012
