The Art and Science of Aging Well

Dr Maya Nicole Baylac

Hawaii Naturopathic Retreat Center bull 239 Haili St Hilo HI 96720 US

The Art and Science of Aging Well

What is Aging Aging is a process of biochemical changes at the cellular

level resulting in cell death decrease of full organ

function and death

Aging is genetically determined and influenced by

environmental factors therefore aging is plastic and can be

delayed minimized or can cause premature death

The aging process starts at 10 years of age with the lowest

mortality rate at 101 After 10 years of age death rates

are doubling every 8 years in western countries and 12

years in eastern countries regardless of menopause or

retirement

1Upton AC Pathology In Finch LE Hayflick L Handbook of the biology of aging New York Van

Nostrand Reinhold 1977 513-35

Aging In Our Culture

Aging is viewed as a negative process

The ideal is to ldquostay young for ever and never dierdquo

Aging is associated with old age and chronic illnessmiddot

Aging tends to be viewed as a disease that can be treated

by medicine with surgery and pharmaceutical drugs

My perspective aging is a noble process Its negative sides

can be attenuated Chronic disease can be avoided or

delayed with healthy lifestyle and healthy nutrition

Normal Aging Process

Organ Atrophy

Brain atrophy and slow loss of neurons in the

prefrontal cortex starting early adulthood causes

memory losses (eg names) insomnia or sleeping

difficulties

Kidneys atrophy after 35 less capacity for filtering the

blood clearing medication and toxic material

Bladder shrinks leading to incontinence and difficulty

voiding

Decreased Hormonal and

Enzyme FunctionDecreased testosterone in males and decreased estrogen in females

leads to decrease in sexual function

loss of muscle mass elasticity strength and flexibility due to loss of muscle fibers

loss of bone density

Reduced production of hydrochloric acid and enzymes

leads to poor digestion

increased vulnerability to bacteria such as H Pylori

Decreased in efficiency of the Immune system (slows repair and healing)

Decreased Metabolism

Vitality decreases

Normal Sign of Aging Hair Graying and thinning of the hair from hair pigment loss

Skin Loss of connective tissue cells causes loss of elasticity loss of sebaceous glands cause poor hydration sarcopenia causes loss of muscle tone resulting in wrinkles sagging skin Melanocyte numbers decrease age spots in sun-exposed areas

Muscle Loss of muscle mass elasticity strength and flexibility from loss of muscle fibers

Abdominal Weight Gain Distribution of fat around the organs widening of the waist area

Skeletal Loss of height loss of minerals such as calcium and phosphorus

Joints May be painful inflamed and stiff from damage to the joint structure

Hearing and vision Decreased function due to loss of specialized cells and blood vessels blockage

Old Age Morbidity

and Mortality

Natural death at the end of the lifespan is rare because chronic disease causes premature death

Prior to the 1900rsquos death was caused by acute disease Medicine introduced Hygiene and antibiotics and eliminated death from infections

Medicine needs to design strategies to extend a healthy life and compress morbidity and disability1 towards the end of the lifespan

1- Eliminate risks factors for chronic illness high blood sugar high blood pressure obesity smoking excessive drinking

2- Maintain organ capacity with healthy lifestyle

1Aging Natural Death and the Compression of Morbidity James F Fries MD The New England Journal of Medicine July 17 1980

Morbidity and Mortality Statistics

USA (2010 CDC)

Number of deaths 2515458

Life expectancy 787 years

White women 803 Black women 768

White men 753 black men 702

Morbidity and Mortality Statistics Heart disease 596577

Cancer 576691

Chronic lower respiratory diseases 142943

Stroke (cerebrovascular diseases) 128932

Accidents (unintentional injuries) 126438

Alzheimerrsquos disease 84974

Diabetes 73831

Influenza and Pneumonia 53826

Nephritis nephritic syndrome and nephrosis 45591

Intentional self-harm (suicide) 39518

Trends in Mortality CVD

Trends in Mortality Cancer

What Causes Aging And

Chronic Illness

Oxidative Stress A Biochemical Theory

of Aging and Chronic Disease

Proposed by Denhan Harman in the 19501

Cellular aging cell death and degenerative disease is due to oxidative stress and mitochondrial dysfunction

Oxidative stress is imbalance between free radicals and anti-oxidants ldquoThe delicate balance between antioxidant defences and ROS production may be disrupted by either deficient antioxidant defences inhibition of electron flow or exposure to xenobiotics This imbalance appears as a common denominator in various pathological processes in which the resulting oxidative insult causes tissue damage and eventually cell deathrdquo

1Bernstein amp Bernstein 1991 Ames amp Gold 1991 Holmes et al 1992 Rao amp Loeb 1992 Ames et al 1993)

Oxidative Stress =

Free Radicals gt Antioxidants

Free Radicals Free radicals are molecules containing one unpaired

electron in their outer shells and they are chemically

very reactive and steal electrons from other molecules

Free radicals combined with oxygen to form reactive

oxygen species (ROS)

ROS are formed as a normal byproduct of oxygen

metabolism but increase with environmental stress

ROS react with the lipids in the cell membrane in

particular polyunsaturated fatty acids

ROS react with the nucleus of the cell

Anti-Oxidants Anti-oxidants are produced to neutralize ROS

Anti-oxidants are molecules that donate an electron to ROS and neutralize ROS preventing reactivity and cell damage

Most known anti-oxidants are

vitamin A C E beta carotene carotenoids

Peptide thiol such as glutathione and its precursor NAC (N acetyl cysteine) lipoic acid flavonoids selenium uric acid

Enzymatic anti-oxidants eg Superoxide dismutase (SOD Cu-SOD Zn-SOD Mn-SOD) catalase glutathione peroxidase

Mitochondria

and Oxidative Stress

The process of energy production creates free radicals in theinner membrane of mitochondria

Free radicals react with oxygen used by the mitochondrial respiratory chain to generate ATP and form ROS

ROS reacts with the membrane of the mitochondria and causes rigidity of the membrane and mtDNA damage

Anti-oxidants such as Glutathione and coq10 protect the mitochondria but production decreases with age

Recent studies show that mtDNA features the same repair mechanisms as nDNA whereas it was believed in the past that it did not repair as well

Mitochondrial Dysfunction Mitochondrial damage reversible at the beginning

mtDNA damage irreversible and thought to cause

aging and disease

The brain and the liver are the most sensitive organs

Brain high oxygen high lipid and low anti-oxidant

therefore sensitive to lipid peroxidation

Liver produces a large amount of free radicals in the

detoxification process

Leakage and Cellular

Damage

Electron leakage from the mitochondrial chain

Damages cellular molecules such as fat protein and

DNA

Cell death

Sources of ROS

Endogenous

Immune system produces free radicals to attack

bacteria

Chronic inflammation

H Pylori

Allergies intolerances

Overweight

Sources of ROS

Exogenous Environmental air and water pollutants radiation UV light

Xenobiotics carcinogenic chemical compounds

Pesticides and herbicides inhaled direct contact or ingested

Trans fat Preservatives and chemicals in foodmiddot

Prescription drugs and Medications esp rx used for treatment of cancer

Free Iron and Toxic metals such as cadmium arsenic mercury iron nickel lead aluminum

Behavior Induced ROS

Emotional stress anxiety related behaviors

Over-Exercising overuse of the body (eg athletes)

Tobacco smoke

Alcohol stimulates the activity of cytochrome P450

(ROS) and reduces anti-oxidants

The Centenarian StudiesA Model for Healthy Aging and Longevity

Lower Incidence of Chronic Disease

Better Survival Rate

Less Disability

Longevity FactorsBeing born

to a Young Mother (18 to 20)

to parents who lived a long life

in November

a female

Positive early life experience

Negative Early Childhood

Experiences Affect Longevity

Early childhood experiences that have a negative effect

on lifespan

Loss of a parent

Suffering virulent environmental insults

Disease load experienced during the first year of

life

Engagement in high risks behavior such as smoking or

excessive drinking

Positive Emotions

Affect Longevity Handwritten autobiographies from 180 Catholic nuns

composed when participants were a mean age of 22 years were scored for emotional content and related to survival during ages 75 to 951

A strong inverse association was found between positive emotional content in these writings and risk of mortality in late life (plt001)

Positive emotional content in early-life autobiographies as strongly associated with longevity 6 decades later2

1Journal of Personality and Social Psychology Vol 80(5) May 2001 804-813

2Positive emotions in early life and longevity Findings from the nun study Danner Deborah D Snowdon David A Friesen Wallace V Journal of Personality and Social Psychology Vol 80(5) May 2001 804-813

Centenarian Studies

A review of Blue zones and Centenarian research

Studies are conducted all over the world in France

Hungary Japan Italy Finland Denmark the United

states and China

Focus has been more on genetics than lifestyle

Centenarians Statistics

Centenarian Statistics Centenarian rate in the US is half the rate of Japan

The proportion of centenarians in the United States is the lowest of all developed countries 173 per 10000 people against 192 in Sweden 195 in the United Kingdom and 270 in France 343 in Japan

The rate is increasing from 1 in 10000 in 1994 to 1 in 6000 in 2010

Super centenarians (older than 110 are 1 in 7 million) 60 to 70 individuals in the US

Centenarians 85 are women 15 are men

Super centenarian 95 are women

Blue Zone LocationsHighest concentration of centenarians

The community of Seventh Day Adventists in the small town of Loma Linda in California

Okinawa Island in Japan famous for the longest disability-free life expectancy in the world

Sardinia Italy with the highest concentration of centenarians

Icaria Greece

Nicoya Peninsula in Costa Rica where healthy centenarians live in a solid support network of friends and family

Blue Zone CharacteristicsGeographic and Ideological Isolation

Centenarians live in isolated areas on an island peninsula or in religious isolation such as the 7th Adventists with little contact with the modern world

They operate as a community and take care of each others needs

They live outdoors a good part of the time and get plenty of sun exposure

They get plenty of physical activity working in the fields walking or bicycling to neighbor locations

They have a strong sense of belonging perpetrate tradition family celebrations

Happy and sense of purpose

Mortality and Disability from

Chronic Disease1

15 no mortality associated diseases at the age of 100 ldquoescapersrdquo

43 suffer chronic diseases before the age of 80 but survive and remain independently functioning ldquosurvivorsrdquo

42 suffer chronic disease after the age of 80 against 60 in the general population ldquodelayersrdquo

ldquoSomehow despite the presence of diseases people who become centenarians donrsquot die from those diseases but rather they are able to deal with them much better than other people and remain independently functioning more than 30 years beyond the age of 60 Author conclusion The identification of three types of centenarians Survivors Delayers and Escapers provides direction for future study into the factors that determine exceptional longevity

1New England Centenarian study Hitt R Young-Xu Y Perls T Centenarians The older you get the healthier yoursquove been Lancet 1999354 (9179)652

Delayed Cancer1 and CVD

Higher Survival Rates Cancer is delayed to the age of 805 years compared

to 632 years in the general population2 (Most common

cancers breast prostate and colon)

88 of centenarians delay or escape the age-related

lethal diseases cardiac disease stroke and diabetes

1Cancer in the oldest old Andersen SL Terry DF Wilcox MA Babineau T Malek K Perls TT Mech Ageing

Dev 2005 Feb126(2)263-7

2National Cancer Institute

Supercentanarian Delay Vascular

Disease and Disability A Super centenarian study revealed

22 were taking medications for High Blood Pressure

19 had a history of MI and stroke

59 were partially or totally dependent

41 require minimal assistance or were independent

Conclusion ldquosuper centenarians markedly delay and even escape clinical expression of vascular disease toward the end of their exceptionally long lives A surprisingly substantial proportion of these individuals were still functionally independent or required minimal assistancerdquo1

1PMID 16913991 [PubMed - indexed for MEDLINE] Related citationsSchoenhofen EA Wyszynski DF Andersen S Pennington J Young R Terry DF Perls TT J Am Geriatr Soc 2006 Aug54(8)1237-40

Italian Multicenter Study on

Centenarians

Ultra-nonagenarians had a lower incidence of

diabetes osteoporosis and gastric ulcer (Italian

Multicenter studies on centenarians)

The Okinawa Centenarians

Study Characteristics Began in 1975

Ages are validated through the ldquokosekirdquo the Japanese family registration system

At the baseline exam a full geriatric assessment is performed including physical exam and activities of daily living

Full assessments of a sub-sample of 900-plus centenarians have been performed

When Dr Suzuki (Principal Investigator of the OCS) first began his studies he found an unusual number of centenarians to be in extraordinarily healthy shape

Longest Health Expectancy

Okinawa Longest life expectancy in the world

Longest health expectancy healthy youthful looking

energetic

Low rate of heart disease stroke cancer even stomach

cancer osteoporosis Alzheimerrsquos

ldquoOkinawa inhabitants reach ages similar to the Japanese

average of 86 for women and 78 for men However the real

encouraging factor is not that people reach these ages but

they grow old in a much better state Some in their 90s

can honestly vouch that they still have an active sex liferdquo1

1Fries JF New England Journal of Medicine 1980303131-5)

The Boston University School of Medicine

New England Centenarian Study1 Alzheimerrsquos

The most extensive study conducted in the US

The study began in 1995 as a population-based study of all

centenarians living within 8 towns in the Boston area The

brain of the subjects were dissected after their death

OBJECTIVE To review the prevalence and incidence of

dementia amongst the exceptionally long-lived

RESULTS Centenarians avoid dementia due to

Alzheimerrsquos and demonstrate no evidence of

neurodegenerative disease

1Perls T Exp Gerontol 2004 Nov-Dec39(11-12)1587-93

Resistance to Dementia

from Alzheimerrsquos 15-25 are functionally cognitively intact

Among those who are not cognitively intact at 100 approximately 90 delayed the onset of clinically evident impairment at least until the average age of 92 yr against 60 in the general population

Despite the substantial presence of neuropathological markers of Alzheimers disease they do not meet clinical criteria for having dementia thus suggesting the existence of cognitive reserve

15 had no mortality associated diseases

90 of all the centenarians were still independently functioning at the average age of 93 years

Few centenarians are obese

Smoking history is rare

Positive Stress Response The New England study reported that centenarians

tended to have an above average ability to handle

stress

The Swedish study reported ldquoPersonality profiles

(MMPI) indicated that the centenarians were more

responsible capable easygoing and less prone to

anxiety than the population in generalrdquo

Anxiety and DepressionThe Padua centenarian study in Italy

38 centenarians (mainly residing in Padua) were interviewed between October 1992 and July 1995

Had lower scores for anxiety and depression than subjects in the 2 younger groups

They considered themselves as religious and satisfied with their financial situation

They reported greater satisfaction with personal and social life

Longevity and Healthy

LifestyleStudy of Seventh Day Adventists at Loma Linda University1

Longest average life expectancy in the United States 88 years for men and 89 years for women (10 more years than the average life expectancy)

Strong faith and family orientation

Their Religion ask that they have very good lifestyle choices they tend to be vegetarian they donrsquot smoke they regularly exercise

ldquoWhat the 7th Day Adventist results show us is that the average American has the genes to reach their mid-late 80s they just need to take very good care of themselves with proper lifestyle choicesrdquo concludes the author

1Vegetarian diets in the Adventist Health Study 2 a review of initial published findings Orlich Michael J Fraser Gary E The American journal of clinical nutrition 2014 Jun 100(Supplement 1)353S-358S

Longevity and Lifestyle FactorsA cohort study involving about 1600 participants in a cohort study1

ldquoPhysical activity such as regular swimming walking or gymnastics was the leisure activity most strongly linked to longevityrdquo

Not smoking and physical activity are associated with longer survival even after the age of 75

Smoking decreases longevity by 1 year former smoker survival was the same as non smokers

The investigators defined a low-risk profile as healthy lifestyle behaviors taking part in 1 or more leisure activity and having a rich or moderate social network They defined a high-risk profile as unhealthy lifestyle behaviors no leisure activities and a limited or poor social network Compared with participants who had a high-risk profile those who had a low-risk profile had an increase in median survival of 54 years

A Healthy lifestyle may improve longevity even into old age according to a population-based cohort study published on line August 30 in the British Medical Journal

Autonomy and Healthy Lifestyle

Preservation of Activities of Daily Living The Japanese centenarian study1

104 were judged to be autonomous centenarians

Autonomy is associated with health practices and physical status

Better visual acuity getting regular exercise spontaneous awakening regularly in the morning preserved masticatory ability having no history of drinking having no history of severe falls after the age of 95 more frequent intake of protein living at home and being male

1J Am Geriatr Soc 2007 Jan55(1)95-101 Ozaki A1 Uchiyama M Tagaya H Ohida T Ogihara R

Autonomy and Healthy

Lifestyle ConclusionsldquoThese findings suggest that health practices play an

important role in preserving ADLs and good cognitive

and psychosocial status after reaching the age of 100 and

should be useful for establishing an educational program

for the ever-increasing super elderly population in

Japanrdquo

Okinawa Diet1

Low-calorie low glycemic diet Consume only 25 the amount of sugar and 75 the amount of fat than what the Japanese eat Diet consists of vegetarian seafood and soy No meat eggs or dairy products

Anti-oxidant rich foods they consume about 300 g of green yellow orange vegetables fruits tubers a day These vegetables are rich in vitamin C A and flavonoids

Calorie control hara hachi bu a cultural habit consisting of only eating until they are 80 full and staying physically active the natural way Average body mass index (BMI) of 18 to 22rdquo

ldquoElderly were found to have impressively young clean arteries low cholesterol and low homocysteine levels when compared to Westerners They have low blood levels of free radicalsrdquo

(1) Okinawa centenarian study Fries JF New England Journal of Medicine 1980303131-5

Okinawa Social Support ldquoIkigai sense of purpose ldquoa reason the get up in the

morningrdquo

The elders here have low depression levels

ldquoYou can see persons aged 90-100 on motorcycles or mountain bikes on the streets Most of them practice karate kendo dancing walk daily several kilometers and even work on vegetable gardens and after that sell the productsrdquo

Social network people take care of each other forming more coherent and supportive links than in the western world They have a positive attitude toward life and low levels of stress

Centenarians Health

Characteristics

Stay healthy longer

Delay both natural signs of aging and chronic

illness

Manage chronic illness better and do not die from it

Less disabled and more autonomous

Personality Traits Happiness sense of purpose faith spiritual

commitment

Sense of responsibility

Resilience and hardiness

Sense of independence

Can handle stress better

No depression or anxiety

Have fun and enjoy themselves

Strong Sense of

Social Belonging

Respect for tradition family religion celebrations

Social activities

-Have a function in their group

-Participation in family and community activities

-Take care of children

-Cook

Family Traits 50 of centenarians have first-degree relatives

andor grandparents who also achieved very old

age and many have exceptionally old siblings

ldquoMany of the children of centenarians (age range of

65 to 82 years) appear to be following in their parentsrsquo

footsteps with marked delays in cardiovascular

disease diabetes and overall mortalityrdquo1

1Hitt R Young-Xu Y Perls T Centenarians The older you get the healthier yoursquove been Lancet

1999354 (9179)652

Lifestyle Factors No smoking drinking or drugs

Meaningful Active Lifestyle walking biking to places

fishing gardening

Rich Social connections

Low environmental toxicity

Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World

What Kills UsSedentary Lifestyle Chronic Sitting

The most important factor for poor health and early death

2012 meta-analysis1 found that those who sat for the longest periods of time on a daily basis were twice as likely to have diabetes or heart disease compared to those who sat the least

Another recent study found that women who sat for more than seven hours a day had a 47 percent higher risk of depressionthan women who sat for four hours or less per day

8 hours of sitting cannot be compensated by an hour of exercise (although it helps)

1Psychology Today March 20 2014

Benefit of Intermittent Movement Interrupt sitting sessions every hour

Standing up or bending down increase the force of gravity on your body and this is the key to counteracting the cellular degeneration that occurs when youre sitting down according to Dr Joan Vernikos former director of NASAs Life Sciences Division and author of ldquoSitting Kills Moving Healsrdquo1

One of the most recent studies2 in this field found that taking a five-minute walk for every hour you spend in your chair can reduce the heart disease risks associated with chronic sitting

Although benefits were shown after just a five minute walk in this study Dr James Levine co-director of Obesity Solutions at Mayo Clinic in Phoenix and Arizona State University recommends getting at least 10 minutes of movement for every hour you sit down

1Sitting kills Moving Heals by Joan Vernikos After 30 years of pioneering research with NASA Joan Vernikos wrote the first book to focus on the fundamental importance of gravity in maintaining youthful vigor In it she applies lessons learned from the experiences of space-traveling US astronauts and Soviet and Russian cosmonauts to ordinary people here on Earth

2Washington Post September 8 2014

Benefit of Walking

COPD and Stroke Walking walking for two miles a day or more can cut your

chances of hospitalization from a severe episode of chronic obstructive pulmonary disease (COPD) by about half Two-year long study published in the journal Respirology1

Another study found that daily walking reduced the risk of stroke in men over the age of 60 Walking for at least an hour or two could cut a mans stroke risk by as much as one-third and it didnt matter how brisk the pace was Taking a three-hour long walk each day slashed the risk by two-thirds

1Respirology February 22014 (Epub ahead of print)

Finding Meaning in the

Modern WorldA Substitute to Traditional Values and

Harmony With Nature

Physical Activities with

Social Meaning

Making the elders feel active members of the community

Meaningful Outdoor physical activities walking or

bicycling to the store or to neighbors or an event

Meaningful relationship with nature gardening or

outdoor contemplation

Group activities in nature walking paddling biking

hiking canoeing etchellip

Creative group activities singing sawing knitting

painting sculpting theater or any hobby

Positive Dynamic

Social Connection Know and help your neighbor

Social connections in the community

Family gathering daily for dinnerlunch

Meaningful social network church or other spiritual and educational group

Continue to be part of the socio-economical network

Gives a sense of belonging and worthGives purpose

Example Have a dog to take for a walk to a park

Social and Physical ActivitiesProtect your Brain from Alzheimerrsquos The shrinking brain needs more

stimulation creativity and brain activity

Regular social activities keep your brain sharp

Challenge yourself to learn and do new things

Be physically active increases blood and oxygen flow to the brain

Avoid these 4 factors1

High blood pressure Diabetes Cigarette smoking Being overweight or obese

1A new study by researchers at University of California Davis Framingham Offspring Cohort Study Neurology the medical journal of the American Academy of Neurology

Create A Life Of

MeaningLoving Relationships and Service to

Humanity

Depression Pessimism

Loneliness and Cancer Epidemiological studies over the last 30 years indicate that

chronic stress depression negative moods feeling of isolation and lack of social support might be risk factors for cancer development and progression1

Chronicity of negative affect as manifested by depressed mood or hopelessnesspessimism appears to have stronger relationships with outcomes than do stressful events2 Psychological status seems to predict the length of survival in several types of cancer such as melanoma non-small-cell lung cancer breast and kidney cancer

1Moreno-Smith M et al Impact of stress on cancer metastasis Future Oncol 2010 Dec6 (12)1863-81

2The influence of bio-behavioural factors on tumour biology pathways and mechanisms Nat Rev Cancer 2006 Mar6(3)240-8 Antoni MH1 Lutgendorf SK Cole SW Dhabhar FS Sephton SE McDonald PG Stefanek M Sood AK

Emotional Stress and Disease

Stress depression and anxiety activate the HPA axis and impair the immune system

Clinically relevant distress is present in 40 to 50 of canceroutpatients (i ii)

Chronic stress predicts the occurrence of coronary heart disease (CHD)(iii)

Employees who experience work-related stress and individuals who are socially isolated or lonely have an increased risk of a first CHD event

A history of stressful life events is correlated with a greater incidence of metabolic syndrome (in men) especially in those men with elevated cortisol (independent of BMI and age) (iv)


(citations)(i) Hoffman et al Screening for distress in cancer patients the NCCN

rapid-screening measure Psychooncology 200413792

(ii) Jacobsen et al Screening for psychological distress in ambulatory

cancer patients Cancer 20051031494

(iii) Steptoe A Kivimaumlki M Stress and cardiovascular disease Nat Rev

Cardiol 2012 Apr 39(6)360-70

(iv) Fabre B et al Relationship between cortisol life events and

metabolic syndrome in menStress 2012 Apr 18

Sleep Hygiene Follow natural rhythms of waking and sleeping

Control light electronic pollution

Sunlight exposure during the day frac12 hour outdoor is

enough

Darkness at night and lights down in the evening

Go to bed early

Do not eat or drink past 6 PM

Circadian Rhythm and Cancer Exposure to sunlight during the day and darkness at

night is an important factor for good sleep

Night-time shift work is a risk factor for breast and

colorectal cancer

Two clinical studies have also shown that cortisol

levels can predict long-term cancer survival1

1Antoni MH et al The influence of bio-behavioural factors on tumour biology

pathways and mechanisms Nat Rev Cancer 20066 (3)240-8

Sleep Alzheimers and Obesity Recent studies show that poor sleeping habits cause

both brain damage and brain shrinkage and may

even accelerate onset of Alzheimerrsquos disease

Previous research published in the journal Science

revealed that the brain removes toxic waste during

sleep through ldquothe glymphatic systemrdquo

Poor sleep has been implicated in obesity in a

number of previous studies

Eliminate Environmental

Toxins Protect the Kidneys Aging kidney do not detoxify so easily

Eliminate tobacco excess alcohol intake

Avoid pharmaceutical drugs as much as possible

Eliminate processed foods soft drinks sugar flour dairy products all these create inflammation

Eat organic food to avoid chemicals pesticides and herbicides

Incorporate large amount of vegetables high in anti-oxidants

Chelation Protect Your Blood

Vessels and Prevent CVD

Chelate heavy metals

EDTADMSA chelation for atherosclerosis heart

disease

Avoid Estrogen Mimicking

Xenobiotics and Cancer1

Consume ONLY organically grown food to avoid carcinogenic toxins

Pesticides in our food have an estrogenic effect

Pesticides cause hormonal cancers such as breast ovarian uterine and prostate cancer

Pesticides cause Early puberty occurring at 10 instead of 16

1Cancers 2010 2 376-396 The Role of Oxidative Stress in Carcinogenesis Induced by Metals and Xenobiotics Frank Henkler Joep Brinkmann and Andreas Luch

Nutritional PrinciplesCalorie restriction

Eating 30 less calories (2000 calories per day) extends life and prevents chronic disease lowers blood pressure improves diabetes decreases inflammation decreases insulin levels and decreases body temperature

Eliminating wheat maybe grains

Dr Perlmutter ldquoGrain Brainrdquo states that glycated hemoglobin HbA1c is one of the greatest predictors of brain atrophy1

1ldquohellip sugar molecules and brain proteins combine to create deadly new structures that contribute more than any other factor to the degeneration of the brain and its functioning The brain is tremendously vulnerable to the glycating ravages of glucose and this is made worse when powerful antigens like gluten accelerate the damage In neurological terms glycation can contribute to the shrinkage of critical brain tissue(p 85 Grain Brain)

Anti-Oxidant Supplementation Acetyl L carnitine

Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C

Superoxide dismutase

Conclusion ldquoDespite the inevitable ups and downs the biggest

secret these centenarians shared is that living to

100 is worth the effort Like climbing a mountain

we should aspire to reach that height not just

because it is there but because the view from the

top is unsurpassedrdquo

Celebrate 100 Centenarian Secrets to Success in Business and life

Lynn Peters Adler JD Steve Franklin PhD

THANK YOU Questions

Hawaii Naturopathic Retreat Center Dr Maya Nicole Baylac

808-933-4400

239 Haili Street Hilo HI 96720 US

contact2013hawaiinaturopathicretreatcom

Visit us on the web

httpwwwHawaiiNaturopathicRetreatcom

Find us on Facebook

httpswwwfacebookcomHawaiiNaturopathicRetreatCenter

What is Aging Aging is a process of biochemical changes at the cellular

level resulting in cell death decrease of full organ

function and death

Aging is genetically determined and influenced by

environmental factors therefore aging is plastic and can be

delayed minimized or can cause premature death

The aging process starts at 10 years of age with the lowest

mortality rate at 101 After 10 years of age death rates

are doubling every 8 years in western countries and 12

years in eastern countries regardless of menopause or

retirement

1Upton AC Pathology In Finch LE Hayflick L Handbook of the biology of aging New York Van

Nostrand Reinhold 1977 513-35











Organ Atrophy




difficulties




voiding











Vitality decreases








Old Age Morbidity

and Mortality








USA (2010 CDC)






Cancer 576691





Diabetes 73831







Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook












Organ Atrophy




difficulties




voiding











Vitality decreases








Old Age Morbidity

and Mortality








USA (2010 CDC)






Cancer 576691





Diabetes 73831







Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook












Vitality decreases








Old Age Morbidity

and Mortality








USA (2010 CDC)






Cancer 576691





Diabetes 73831







Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook









Old Age Morbidity

and Mortality








USA (2010 CDC)






Cancer 576691





Diabetes 73831







Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook



USA (2010 CDC)






Cancer 576691





Diabetes 73831







Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook



Cancer 576691





Diabetes 73831







Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





Chronic Illness







Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook








Oxidative Stress =


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


















Mitochondria









aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook




aging and disease







Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook



Damage



DNA

Cell death

Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Sources of ROS

Endogenous


bacteria


H Pylori


Overweight

Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Sources of ROS










Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





Tobacco smoke






Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





Less Disability




in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





in November

a female





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





on lifespan

Loss of a parent



life


excessive drinking

Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Positive Emotions







Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Centenarian Studies




states and China













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook













Icaria Greece










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook










Chronic Disease1













Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook









Dev 2005 Feb126(2)263-7











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook











Centenarians













energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook











energetic































stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook
























stress



































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook
































Japanrdquo

Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Okinawa Diet1







morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook



morningrdquo




Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Centenarians Health

Characteristics

Stay healthy longer


illness




commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook



commitment







Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Strong Sense of

Social Belonging


Social activities




-Cook









1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook










1999354 (9179)652



fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook




fishing gardening



Spontaneous waking

Outdoor living

How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


How Can We Apply

This Model To Our

Modern World













Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook














Benefit of Walking







Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook




Harmony With Nature


Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook



Social Meaning










Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


Positive Dynamic
















Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook










Create A Life Of


Humanity



















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook




















Cardiol 2012 Apr 39(6)360-70






enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





enough


Go to bed early





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





colorectal cancer
























disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook





















disease














Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook















Lipoic acid

Co Q Ubiquinol

Glutathione (GSH)

Vitamin E C










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook










THANK YOU Questions


808-933-4400



Visit us on the web


Find us on Facebook


The Art and Science of Aging Well

Health & Medicine

Transcript of The Art and Science of Aging Well