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![Page 1: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/1.jpg)
The application of multiscale modelling to the process of development and prevention of stenosis in a stented
coronary artery
by D.J.W Evans, P.V Lawford, J Gunn, D Walker, D.R Hose, R.H Smallwood, B Chopard, M Krafczyk, J Bernsdorf, and A Hoekstra
Philosophical Transactions AVolume 366(1879):3343-3360
September 28, 2008
©2008 by The Royal Society
![Page 2: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/2.jpg)
Background to arterial structure and stenting.
D.J.W Evans et al. Phil. Trans. R. Soc. A 2008;366:3343-3360
©2008 by The Royal Society
![Page 3: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/3.jpg)
Schema of the classical wound healing response.
D.J.W Evans et al. Phil. Trans. R. Soc. A 2008;366:3343-3360
©2008 by The Royal Society
![Page 4: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/4.jpg)
Scale separation diagrams.
D.J.W Evans et al. Phil. Trans. R. Soc. A 2008;366:3343-3360
©2008 by The Royal Society
![Page 5: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/5.jpg)
SSMs for ISR. (a) Comprehensive SSM for ISR. (b) Simplified version of the SSM showing the minimum number of explicitly modelled processes considered necessary for the system model
to remain representative.
D.J.W Evans et al. Phil. Trans. R. Soc. A 2008;366:3343-3360
©2008 by The Royal Society
![Page 6: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/6.jpg)
Representation of the interaction algorithm for ISR.
D.J.W Evans et al. Phil. Trans. R. Soc. A 2008;366:3343-3360
©2008 by The Royal Society
![Page 7: The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery by D.J.W Evans, P.V Lawford,](https://reader036.fdocuments.in/reader036/viewer/2022062322/56649e385503460f94b2892c/html5/thumbnails/7.jpg)
Single-scale models relevant to ISR. (a) Lattice Boltzmann flow solution and computed clot distribution in the region of sharp-edged stenosis (Harrison et al. 2007).
D.J.W Evans et al. Phil. Trans. R. Soc. A 2008;366:3343-3360
©2008 by The Royal Society