THE ACTIVITY BALANCE OF PLATELET COLLECTION BY APHERESIS OVER A PERIOD OF 72 MONTHS (2006-2011)

AT SINGLE CENTER IN ALGERIA

R.Belhadj; R.Ahmed-nacer; M.Benakli;

N.Rahmoune; F.Mehdid; A.Talbi M.Baazizi; D.Ait-Ouali; S.Akhrouf; F.Mehenou;

RM.hamladji.

Department of Hematology and BMT unit, Pierre and Marie Curie Center, Algiers, Algeria.

INTRODUCTION

• The platelet transfusion is a surrogate therapeutic way to offset a deficit induced by disease or cytotoxic therapy.

• Platelet transfusion can be a life-saving procedure in preventing or treating serious complications from bleeding and hemorrhage in patients who have disorders manifesting as thrombocytopenia  or platelet dysfunction.

• This transfusion is a necessary and constant part of hematologic reanimation.

• We present the activity balance of platelet collection in our center.

Material and methods

• Period 72 months : (2006-2011):

5548 sampling platelet concentrate units PCU (924 / year).

• Origin of donations (PCU): family + + ++                    volunteers

Material and methods

Terms of sampling:

Personal qualified.Questioning.Physical examination.Laboratory study: complete blood count: rate plat ≥ 150×109/l           Blood group.           Viral serology: VIH, HbS, CVH, Syphilis (negative)

The platelet concentrate unit performed on a single donor thanks to a automated cell separator model TRIMA.

Material and methodsTRIMA Accel : N= 3 Agitator: N=2

• Continuous flow separator. • BV extracorporeal low.• A Better hemodynamic tolerance

•continuous Horizontal agitation.•Conservation 5-7 days.•Temperature 22 0 C

Material and methods

DISTRIBUTION BY GENDER: male predominance (93,2%)

ONLY 379 (6.8%) are femaleP50 Amiri Nadia TUNISIA:(97,5% donors is the young males)

673

14521272 1232

Material and methods

REPARTITION ACCORDING TO THE TYPE OF

DONATIONS Donations Volunteers: 512 (9.2%)

RESULTS

N = 5548Before apheresis After apheresis Loss

(%)

Hematocrit (%) (average)

41,9 (30,1 – 57,6) 40,5 (30 – 56 ) 3,34

rate plat (109 /l)(average)

262 ( 150 – 491) 163 (79 – 335) 37

BLOOD DONORS RATES BEFORE AND AFTER APHERESIS

RESULTS

N = 5548 VALUES AFTER APHERESIS

Volume deals average (ml)

3479 ( 890 – 5213)

Volume of ACDA average (ml) 314,1 (91 – 505 )

Collection volume bag average (ml) 386 (50 -647)

Plat. average yield / bag (10 11 ) 5,8 ( 1 – 8)

Duration of procedure (min) 63,71 (19 – 120 )

VALUES OF PROCEEDINGS GIFT OF PLATELET CONCENTRATE UNITS

RESULTS

Cancelled samples N = 76 (1.35%):poor donor tolerance /poor venous access

RESULTSUNITS USERS NUMBER %

STERILE UNIT (BMT/ INDUCTION CT) 3495 63

GENERAL HEMATOLOGY CENTER 1110 20

HEMATOLOGY DAY HOSPITAL / CONSULTATION

888 16

EXTRA MURAL CENTER 63 1

TOTAL 5548 100

DISTRIBUTION OF USER UNITS

RESULTS

Number of donation

Donors volunteers

AGAINST PART

BTC/ T-O (2005- 2009) 47.774 14 % 86 %

OUR CENTER ( 2006-2011) 5548 9,2 % 90,8 %

L.Ainas Revue Algérienne d’hématologie N° 5 septembre 2011: prévalence des infections VIH; VHC et Syphilis chez les donneurs de sang au CTS de (2005-2009)

COMPARISON RATES OF VOLUNTEERS DONORS IN BLOOD COMPONENT : PCU : our center / Red Blood Unit : Blood Center tranfusion (BTC) Tizi-ouzou (TO)

DISTRIBUTION OF PUC / YEAR IN ALGERIA : Multicentric study of 1 year (2009)

BTC PLATELETS SAMPLS % NUMBER OF MACHINS FOR CYTAPHERESIS

OUR CENTER 1452 54 3

UHC Oran 504 18,74 1

UHC SBA 340 12,64 2

UHC Batna 125 4,64 1

UHE Oran 119 4,42 1

Beni Messous 94 3,49 1

Tizi-Ouzou 45 1,7 1

BTC Blida 10 0,37 1

TOTAL 2689 100 11

S. Nekkal, M.Belhani .Revue Algérienne d’hématologie N° 5 septembre 2011 : la transfusion de plaquettes en hématologie: le point en 2009 Etude multicentrique

Conclusion

• The platelet transfusion is very important in hematologic reanimation.

• Despite the large number of donations (PCU) per year; it remains insufficient because of the lack of voluntary donors especially in summer and the month of Ramadan.

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