Thank you CBS friends · Twin Cities campuses to serve as an incubator for biotech compa-nies. The...

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FACULTY RESEARCH ALUMNI PROFILES DONOR HONOR ROLL Now that Campaign Minnesota is over, we’d like to thank our friends for their gifts to the College of Biological Sciences. From $25 to $10 million, they’re all important and very much appreciated. Pictured are Denny and Joan Dvergsten, longtime CBS supporters. Page 9 FACULTY RESEARCH ALUMNI PROFILES DONOR HONOR ROLL Thank you, Thank you, CBS friends CBS friends

Transcript of Thank you CBS friends · Twin Cities campuses to serve as an incubator for biotech compa-nies. The...

Page 1: Thank you CBS friends · Twin Cities campuses to serve as an incubator for biotech compa-nies. The incubator is an anchor for a planned life sciences corridor that city officials

F A C U L T Y R E S E A R C H • A L U M N I P R O F I L E S • D O N O R H O N O R R O L L

Now that Campaign Minnesota is over, we’d like to thank our

friends for their gifts to the College of Biological Sciences.

From $25 to $10 million, they’re all important and very much

appreciated. Pictured are Denny and Joan Dvergsten,

longtime CBS supporters. Page 9

F A C U L T Y R E S E A R C H • A L U M N I P R O F I L E S • D O N O R H O N O R R O L L

Thank you,Thank you,CBS friendsCBS friends

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This summer the city of St. Paul bought a warehouse between the

Twin Cities campuses to serve as an incubator for biotech compa-

nies. The incubator is an anchor for a planned life sciences corridor

that city officials hope will make St. Paul a center for biotechnology.

This is extremely good news for the College of Biological Sciences.

The proposed corridor will provide internships and jobs for CBS stu-

dents and give faculty a place to develop their ideas for products.

The incubator was proposed by University Enterprise Laboratories, a nonprofit partnership

created by the College of Biological Sciences, Carlson School of Management, and the

University of Minnesota Foundation. Campaign Minnesota helped launch UEL by raising

corporate and public awareness of the role biology could play in economic development.

I helped to organize UEL because I saw the pressing need for a place where academia and

industry could work side by side to develop Minnesota’s biotechnology industry. It began

with the opening of Biodale, our center for research services, which brought small and

large biotech companies to our door and allowed us to become better acquainted with

them. As a result, we have provided temporary lab space for several of these companies.

We also learned that in today’s market, small fish — start-up companies — develop new

products and big fish — companies like 3M, Cargill, and Medtronic — acquire them. And

we realized that while many states had created ponds for their small fish, Minnesota had

not done so and was rapidly falling behind.

It’s important for Minnesota’s economic health that we provide Minnesota’s large compa-

nies with small fish. If not, we could lose them to better feeding grounds on the west or

east coasts. We also hope some of these small fish become big fish.

The incubator is a start. It’s a pond where small fish can feel at home, and where new ideas

can bubble up to the surface. I am very excited to see what develops there and where it will

lead us. I hope you are too.

Robert Elde, DeanCollege of Biological Sciences [email protected]

C O L L E G E O F B I O L O G I C A L S C I E N C E S

FROM THE DEAN

Address correspondence to:[email protected]

Visit our Web site at www.cbs.umn.edu.

Robert Elde, Dean

FALL 2003 ■ Vol. 2 No. 3

DEANRobert Elde

EDITORPeggy Rinard

ADVISERSAssociate DeansJudd SheridanResearch and International Programs

Robin WrightFaculty and Academic Affairs

Department HeadsDavid BernlohrBiochemistry, Molecular Biology, and Biophysics

Robert SternerEcology, Evolution, and Behavior

Kate VandenBoschPlant Biology

Brian Van NessGenetics, Cell Biology, andDevelopment

CONTRIBUTORSEmily Johnston

Jean Marie Lindquist

GRAPHIC DESIGNShawn Welch U of M Printing Services

PRINTINGU of M Printing Services

UEL incubator: Small biotech fish get a pond of their own

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IN THIS ISSUE

B I O ❙ F A L L 2 0 0 3 1

COVER STORY

FEATURES

IN EVERY ISSUE

9 Thank you, CBS friendsNow that Campaign Minnesota is over, we’d like to thank our friends for their gifts to the College of Biological Sciences. From $25 to $10 million, they’re all important and very much appreciated.

18 Donor Honor Roll

2 AbstractsPacker recognized for lion behavior discoveries…Pusey to headGoodall chimpanzee research… Rainforest residents visit CBS…

4 College NewsCargill Building dedicated…Cargill funds CBS Chair in HumanMetabolism…Legislation benefits CBS… Incubator site chosen…CBSCommencement 2003…

14 Alumni NewsMeet new BSAS president Mervyn de Souza, “the kind of person youjust like to be around.”

15 Class NotesRead about your classmates. Let us know what you’ve been doing.

22 Calendar of Events

On the Cover Denny Dvergsten and his wife, Joan, are among the many friends of CBS who provide criticallyneeded private support for scholarships and new initiatives. Denny, who spent his career as a high schoolbiology teacher, later directed a high school outreach program at CBS. Read more about them on page 11.Photo by Tim Rummelhoff

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Cargill Building tenants

The University of Minnesota is committed to the policy that all persons shall have equal access to its programs, facilities, and employment without regard to race, color, creed, religion, national origin, sex, age, marital status, disability, public assistance status, veteran status, or sexual orientation.

Printed on elementally chlorine-free recycled paper containing 20 percent post-consumer waste.

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Mammalogist Sharon Jansa

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Mervyn de Souza, BSAS President

BIO is published three times a year by theUniversity of Minnesota College of BiologicalSciences for alumni, faculty, staff, and friendsof the College. It is available in alternative for-mats upon request; please call 612-624-0774or fax 612-624-2785.

6 DEVELOPMENTAL BIOLOGY — Development of a first-rate biologist.

7 PLANT BIOLOGY— New plant genomics faculty move into Cargill Building.

12 FIELD NOTES — Mammals from Madagascar to Minnesota.

13 BIOTECHNOLOGY – Microbes with a mission, world’s worst paint.

16 ALUMNI PROFILE — Meet Kip Thacker, biotech entrepreneur and advocate.

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2 C O L L E G E O F B I O L O G I C A L S C I E N C E S

Craig Packer, Distinguished McKnightProfessor in the Department of

Ecology, Evolution, and Behavior, was elected to the American Academy of Artsand Sciences, joining U.N. Secretary-General Kofi Annan and journalist WalterCronkite among 216 new members for 2003.

Packer, who joined the CBS faculty in 1983, is known for his studies of Africanmammals. Working with baboons, heshowed that animals have built-in mecha-nisms to avoid inbreeding. From his obser-vations of animal cooperation, especiallyamong primates and carnivores, he foundthat it is possible to predict when animalswill work together to hunt.

“Animals hunt together when they would beincompetent hunting alone,” Packer says.“When they don’t need to cooperate, theydon’t. This pattern has been seen in birds,

lions and other carni-vores, and primates.”

Packer has investigat-ed other animalalliances, such asgroup living amonglions. Unlike othercats, lions live togeth-er because their openhabitat makes themvulnerable to rivals. Heled efforts to protectlions on the SerengetiPlain from distemperbrought to the area bydomestic dogs. And heis now heading a studyof the Serengeti’s bio-complexity to learn how the ecosystem—including human residents—functions.Packer received a Guggenheim Fellowship

in 1990, and in 1995 his book “Into Africa,” apersonal account of his journeys to the con-tinent, won the John Burroughs Medal. ■

Craig Packer cares for aNgorongoro Crater lionduring a 2001 epidemic.

Packer elected to Academy of Arts and Sciences

Anne Pusey named Goodall’s Executive Director of ResearchAnne Pusey, director of the Jane GoodallInstitute’s (JGI) Center for Primate Studies atthe College of Biological Sciences, has beennamed executive director of research at JGI.She will oversee all chimpanzee research inTanzania’s Gombe National Park, while continu-ing as Distinguished McKnight Professor in theDepartment of Ecology, Evolution, and Behavior.

Pusey studied the development of youngGombe chimpanzees under Goodall, receivinga doctorate from Stanford University in 1977.She takes the helm at Gombe just asresearchers are answering key questionsabout chimp behavior, such as which

males have fathered which infants,whether paternal relatives can recognize

each other, and whether kinship is

important in cooperation and altruism.Researchers are also beginning to under-stand how mothering styles influenceinfants, causes of lethal inter-communityaggression, and the nature of female com-petition.

She will also work with JGI staff andTanzanian authorities on issues thatthreaten the park and chimpanzees, suchas deforestation of nearby areas andtransmission of human diseases.

The Center for Primate Studies housesGoodall’s data from 40 years of chim-panzee studies. To make an online dona-tion to preserve these records, go tohttp://www.giving.umn.edu/index.html. ■

Anne Pusey has worked with Goodall since she was a graduate student.

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George Weiblen, assistant professor of plant biolo-gy, hosted three visiting parataxonomists fromPapau-New Guinea this summer. They came toMinnesota to learn how to identify and preservethe wealth of plant and insect species in theirnative rainforest.

Papua-New Guinea ranks with the Amazon andthe central Congo basin among the world’s greattropical wildernesses. But it could all disappear ifthe New Guineans themselves don’t take chargeof their natural resources and protect theimmense number of species there.

Although the people of Papua-New Guinea recog-nize huge numbers of plants and insects, theyneed training to document the species diversitythat surrounds them and pass their knowledge—and passion for preservation—to the next genera-tion. With 98 percent of land in New Guinea undertribal ownership, it’s crucial that native people

become aware of the value of their naturalresources. The New Guineans visiting Weiblenthis week are bridges to the population at large,including children.

“As the country develops, the people face limitedresources, and we’re making them aware of this,”Weiblen says. “Traditional knowledge is disap-pearing. We’re documenting the names and usesof plants in a land where 25 percent of the world’slanguages are spoken. We try to make a bigimpact with a small amount of money.” ■

DDUUNNCCAANN CCLLAARRKKEE,, assistant professor of genetics, cell biology, and develop-ment, has been awarded a five-year grant from the National Cancer Institute tostudy “Budding Yeast S-Phase Checkpoint Control.” His goal is to identify factorsthat ensure the genome is fully replicated before cells attempt division.Recommended total for the five-year period is approximately $1.6 million.

SSTTEEPPHHEENN EEKKKKEERR,, associate professor of genetics, cell biology, and develop-ment, received $356,477 from the National Institutes of Health for “InsertionalMutagenesis in Zebrafish by SB Transposons.” Perry Hackett, professor ofgenetics, cell biology, and development, is co-principal investigator. SleepingBeauty, which was developed by Hackett to transfer DNA, can be used for genetherapy and gene discovery. In this case it will be used to develop zebrafish inwhich genes have been inactivated by the transposon. Ekker and colleagues areusing this system to identify genes involved in communication between cells asa part of understanding vertebrate development.

SSUUEE GGIIBBSSOONN,, associate professor of plant biology, received $330,000 from theDepartment of Energy to study plant development and metabolism. See thearticle about her research on page 7.

AARRKKAADDYY KKHHOODDUURRSSKKYY,, assistant professor of biochemistry, molecular biology,and biophysics, has been awarded $1.4 million over five years from the NationalInstitutes of Health for his research on “Structure and activity of Escherichia colichromosome.” Khodursky also has published “Methods in Molecular Biology,”volume 224, “Functional Genomics: Methods and Protocols;” Editors:Brownstein, M.J. (NIH) and Khodursky, A.B. (UM), Humana Press. The book,aimed at researchers who use whole-genome microarray technology, is the firstcomprehensive issue on contemporary methodologies in functional genomes.

GGAARRYY NNEELLSSEESSTTUUEENN,, holder of the Kirkwood Chair in Biochemistry, has licensedpatents for proteins to treat coagulation disorders to Maxygen, Inc., a Californiabiotechnology company that develops and manufactures genes and proteins fortherapeutic uses.

MMIICCHHAAEELL OO’’CCOONNNNOORR,, Ordway Professor of Developmental Biology, was promot-ed to full investigator by the Howard Hughes Medical Institute, which will con-tinue his funding for the next seven years. To read about his research, see thestory on page 6.

DDAAVVIIDD SSTTEEPPHHEENNSS,, associate professor of ecology, evolution and behavior,received a four-year grant for approximately $338,000 from the National ScienceFoundation for “Animal Impulsivity: Discounting or Ecological Rationality.”

JJOOHHNN WWAARRDD,, associate professor of plant biology, will receive $330,000 forthree years from the Department of Energy, Energy Biosciences Program, for“Analysis of Arabidopsis Sucrose Transporters.” The project will focus on trans-port properties, regulation, and protein interactions of sucrose transporters,which are membrane proteins important for the long-distance transport ofsucrose within the vascular tissue of plants. ■

Weiblen teaches rainforest residents to identify species

B I O ❙ F A L L 2 0 0 3 3

Grants and Awards

George Weiblen, assistant professor of plant biologysecond from left), with Richard Kutil, Brus Isua, andJohn Auga, who came to Minnesota from Papua-NewGuinea to learn about preserving rainforest species.

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Cargill Building positions U of M for genomics leadership

4 C O L L E G E O F B I O L O G I C A L S C I E N C E S

The University of Minnesota took abig step towards national leader-

ship in genomics research with theMay opening of the Cargill Building forMicrobial and Plant Genomics on theSt. Paul campus. The $20 million,64,000-square-foot facility is the first of its kind at a public researchuniversity.

At the opening, Cargill CEO WarrenStaley announced a $1 million gift to theUniversity to fund the Cargill Chair inSystems Biology of Human Metabolismat CBS. President Bruininks announcedthat the money will be matched with$500,000 in University funds to supportgraduate fellowships.

Later that afternoon, more than 130people attended a lecture by specialguest Claire Fraser, president of TheInstitute for Genomics Research inWashington, D.C., and saw her receive anhonorary doctor of science degree fromthe University. Fraser is the country’sleading expert on microbial genomics.

The Cargill Building will house fifteenteams of scientists. Many will focuson pathogenic microbes or beneficialmicrobes with uses in agriculture,environmental clean-up, and healthcare. Others will direct their attentionto technology for screening biologicalagents and analyzing data. Their basicresearch provides a foundation forfuture applications that could makecrops more resistant to disease anddraught, reveal new ways to improveanimal and human health, and restorethe environment. Most already haveobtained federal funding.

The Cargill Building is an importantcomponent of the University-wideeffort in genomics and the corner-stone of the planned University ofMinnesota Biotechnology Precinct onthe St. Paul campus. Future buildingswill provide space for research on bio-catalysis, bioenergy, biomaterials, andbiosensors. ■

New legislation will benefit CBS

Charles Muscoplat, dean of the College of Agricultural, Food, and Environmental Sciences;Claire Fraser, director of The Institute for Genomics Research; Ronald Phillips, director of theCenter for Microbial and Plant Genomics; Warren Staley, CEO of Cargill; President RobertBruininks; Governor Tim Pawlenty and Dean Robert Elde.

BIO, the College of Biological Sciences maga-zine, won a MaroonAward from theUniversity of Minnesotaand an Award of Meritfrom MinnesotaGovernmentCommunicators for2003. Both awardswere for quality ofediting, design, writ-ing, and photography as well as effectivenessand prudent use of resources. ■

BIO wins two awards

Two initiatives approved by the Legislature

in May will give CBS a boost.

The “Prairie Island” bill provides about

$20 million for the University’s Initiative for

Renewable Energy and the Environment

over five years. Funds will be used for

research on hydrogen and other renewable

energy sources. Dean Elde, Rep. Steve

Kelly, and MNBIO led efforts to promote

this legislation, which redirects money utili-

ty companies set aside for alternative ener-

gy development.

The Omnibus Tax Bill allows the state to

designate two tax-free zones for develop-

ment of biosciences businesses. One likely

will be located along the transitway

between the Minneapolis and St. Paul

campuses, where the University

Enterprise Laboratories, Inc. incubator

will be located. Dean Elde, MNBIO

Executive Director Ray Frost, and St. Paul

Mayor Randy Kelly, among others, testi-

fied at the Legislature to promote creation

of the zones.

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B I O ❙ F A L L 2 0 0 3 5

Commencement for the class of 2003 washeld in Northrop Auditorium on May 17. Ofthe 273 seniors who graduated during theyear, 175 participated in the year-end cere-mony. More than 50 students graduatedwith honors.

Chris Maziar, Executive Vice President andProvost was guest speaker. Student speak-ers were Mathew Abdel, biochemistry;Charles Hernick, ecology, evolution and

behavior; and Michelle Gleason, genetics,cell biology, and development. Abdel and

Hernick also receivedawards for student lead-ership.

Claudia Neuhauser,assistant professor ofecology, evolution, andbehavior, received theStanley Dagley-SamuelKirkwood UndergraduateEducation Award fordeveloping the courseand corresponding textbook “Calculus forBiology and Medicine.” Rob Brooker, asso-ciate professor of genetics, cell biology,and development, was recognized for win-ning the Horace T. Morse–University ofMinnesota Alumni Association Award forOutstanding Contributions to UndergraduateEducation.

Brian Barber, Ian Gilby, and Tanya Smutka,all from ecology, evolution, and behavior,received awards as this year’s outstandingteaching assistants.

Alumna Pearl Bergad (M.S. in Botany, ‘69)received the Outstanding Achievement

Award from the University for serviceto Chinese Americans in Minneapolisand use of music to improve under-standing among people of different cul-tures. Bergad’s most notable accom-plishment was working with theChamber Music Society of Minnesotaand cellist Yo-Yo Ma, among others, toplan and produce Hún Qiáo [Bridge ofSouls], a musical program of remem-brance andreconcilia-

tion for Asianswho died inWorld War II.Bergad hasspent her careeras a scientist forthe University ofMinnesotaMedical School.She and herhusband, BobBergad, also aCBS alumnus,have two sons. ■

A laboratory “incubator” for fledglingstart-up companies will be nested in aMidway district warehouse purchasedby the City of St. Paul in July.

The warehouse, formerly used byTarget Corp., is located adjacent to thetransitway between the Minneapolisand St. Paul campuses, which allowsconvenient access for University facul-ty and students.

About a third of the building’s 125,000square feet will be used to house asmany as 25 start-up companies. Sevencompanies now located in University of

Minnesota buildings, primarily SnyderHall and Gortner Laboratories at CBS,are expected to move in. The buildingwill be ready for its first tenants inFebruary, and construction is expectedto be completed next summer.

University Enterprise Laboratories(UEL), a nonprofit organization affiliated with the University, is raising $10 million in corporate contributions tofund the $20 million project. CBS DeanRobert Elde, chairman of UEL’s board, isleading the fundraising effort. ■

St. Paul buys site for biotech incubator Eloise Newcomb PittmanThe Eloise NewcombPittman Scholarship wasestablished by Pittman’smother, according toJean McIntosh, who knewPittman while both werebotany students in thelate 1930s and early1940s. Pittman died at ayoung age from a raredisease. “She was a brilliant student, fun per-son, and a good friend,” McIntosh says. The fundwas mentioned in the article about alumnusMary Kemen in the winter 2003 issue of BIO. Ifyou have more memories to share aboutPittman, send to [email protected] or call612-624-0774.

Pearl Bergad, (M.S. Botany, ‘69), winner of theOutstanding Achievement Award, with Dean Eldeand Douglas Pratt, professor emeritus of plantbiology, who was her adviser.

Claudia Neuhauser,winner of the Dagley-Kirkwood award.

Rob Brooker received theMorse-Alumni award forundergraduate education.

Eloise NewcombPittman

College of Biological Sciences Commencement 2003

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How does a fertilized egg

It’s a good thing MichaelO’Connor likes solving mysteries, because he’s

taken on one of nature’s mostchallenging: How does a singlefertilized egg manage to developinto an adult fly, fish, or first-ratebiologist?

O’Connor, a professor of genetics,cell biology, and development, hasidentified enough clues to impresshis toughest audience. He recentlywent before a panel of 30 scien-tists asked to decide if his work

merited renewal of his status asan investigator of the HowardHughes Medical Institute. An inde-pendent institute with an endow-ment close to $12 billion, HHMIsupports about 350 of the topmedical researchers in the country, including a handful ofNobel laureates. O’Connor hadjust finished a five-year stint as anassociate investigator with HHMI,which paid his salary, his labresearchers’ salaries, and operat-ing expenses.

The only HHMI investigator inMinnesota, he was carrying a flagfor the state, CBS, the University—and children born with holopros-encephaly, the most commondefect of the face and cranium.

“Holoprosencephaly occurs in oneout of every 5,000 newborns,” saysO’Connor. “It can be as mild ashaving a single front tooth or assevere as having a single eye, acondition called cyclopia.”

Working with fruit flies and mice,O’Connor and his colleagues haveidentified several proteins thathelp the embryo figure out, liter-ally, which side is up. One suchprotein is called BMP. At the pointin development when the bodydetermines which is the top (back)side and which is the bottom(belly) side, cells respond accord-ing to the levels of BMP theydetect. That is, the amount ofBMP tells cells where they fit inthe general body plan.

The body also makes proteins thatattach to BMP and inhibit itsaction. The more inhibitors, the

less BMP a cell detects. Together,BMP and its inhibitors act to forma top-to-bottom gradient thatguides the formation of tissues.BMP tends to concentrate in ashallow strip along the mid-back.O’Connor found that mouseembryos lacking one of the BMPinhibitors were born with holo-prosencephaly.

This finding led to more ques-tions. How many genes areinvolved in the various degrees ofhuman holoprosencephaly? Doesthe primary gene (or genes)mutate spontaneously, or aremutations passed down throughfamilies? If mutations show afamilial pattern, a diagnostic testmight be developed to identifyparents or early-stage embryos atrisk, O’Connor says.

O’Connor also showed that BMPand its inhibitors are involved innervous system function in fruitflies. If they play similar roles inhumans, they may be part of thereason young nerve cells canrespond by strengthening orweakening their interconnec-tions—the basis of learning andmemory.

“We’re going to test whether thesefactors are involved in postnatalsynapse [connections betweennerve cells] development in brainsof mice, and, later, humans,”O’Connor says.

And about that renewal panel. Itpromoted O’Connor to full investi-gator, the highest rank of HHMI-supported scientist.

—Deane Morrison

6 C O L L E G E O F B I O L O G I C A L S C I E N C E S

Michael O’Connor is the only Minnesota sci-entist supported by the Howard HughesMedical Institute. His funding was justrenewed for seven years.

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How does a plant knowwhen and where to builda bud? How does it

defend itself when attacked byfungi or other foes? The answersto questions like these lie hiddenwithin its genetic material.Understanding the link betweenspecific genes and the processesand products of life is the busi-ness of functional genomics—andof several new faculty who havejoined the Department of PlantBiology in recent months. Theirresearch not only is enriching ourunderstanding of plant physiolo-gy, it’s also providing informationthat could be used to help plantsbetter serve human needs bydoing things like make more fruitor resist yield-robbing disease.

Sue Gibson, who came toMinnesota last August, is focusingon the role of sugars in plantdevelopment. “Although we knowit’s highly regulated, we under-stand very little about how it’sregulated,” she says. “How does aplant know how much of itsresources to allocate to leaves asopposed to roots?”

Colleague Jane Glazebrook isexploring another feature con-trolled by genes: the internalsignals plants send out in thepresence of disease organismssuch as bacteria or fungi. She,too, is asking her questions atthe genetic level—which genesare activated by the enemy, andwhat kinds of processes doeseach initiate?

Both Gibson and Glazebrook arelooking for answers on DNA

chips—tiny glass slides uponwhich are arrayed in gridlike formmost of the 25,000 or so genes ofArabidopsis thaliana, the botani-cal equivalent of the laboratoryrat. To study the role of variousgenes in a particular event, theresearchers expose the slides toRNA derived from the tissue ofArabidopsis plants undergoingthe event. The derived RNA then“tags” genes on the chips corre-sponding to those active duringthe event. By comparing resultsfor normal plants and plants withmutations affecting their ability tocarry out the process understudy, the researchers can homein on which genes do what.

Sound complicated? Actually,that’s the easy part. Far more dif-ficult is figuring out what the var-ious patterns of tagged anduntagged genes mean.

Which is where Fumi Katagiri,who arrived with Glazebrook thissummer, comes in. LikeGlazebrook, Katagiri is studyingplants’ gene-level response todisease organisms. But he wearsanother hat, too: that of DataMiner. Like a miner tunnelingthrough the earth in search ofcoal, Katagiri—with the help ofcomputer programs he writes—digs his way through the reamsof results generated by DNAchips in search of relationshipsbetween gene activity and physio-logical change.

“A huge amount of data can begenerated—but what informationis in there? That’s the real chal-lenge,” he says.

All three of the new scientists areheadquartered in the also-newCargill Building for Microbial andPlant Genomics. They’re enthusi-astic about the way the building’sopen layout allows them and theirideas to bump into each other ona regular basis.

“For scientists, it’s always good tointeract,” Glazebrook says.

—Mary K. Hoff

New faculty study how‘green genes’ control plant processes

New faculty Jane Glazebrook, Fumi Katagiri, and Sue Gibson, all members of theplant biology department, will work in the new Cargill Building for Microbial andPlant Genomics.

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Like a miner tun-

neling through the

earth in search of

coal, Katagiri digs

his way through

reams of informa-

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DNA chips.

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8 C O L L E G E O F B I O L O G I C A L S C I E N C E S

Dean Elde with Cargill CEO Warren Staley andGovernor Tim Pawlenty at the dedication of theCargill Building for Microbial and Plant Genomics.Cargill’s $10 million gift for construction of the$20 million building was matched by the State.

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Now that Campaign Minnesota is over, we’d like to thank our friends for theirgifts to the College of Biological Sciences. From those who gave $25 to thosewho gave $10 million, they’re all important.

B I O ❙ F A L L 2 0 0 3 9

hile academic excellence has elevated theCollege of Biological Sciences into the cat-egory of elite public and private colleges, it

may be the College’s financial vitality that keeps itcompetitive and affordable for the best and brighteststudents.

So, as the curtain draws shut on a very successfulfundraising campaign at the University of Minnesota,CBS is taking a moment to reflect on the generosity ofits many donors and the impact of—and continuingneed for—their myriad gifts.

The final tally for Campaign Minnesota, which began in1996, is truly impressive: more than $1.6 billion in overallcontributions to the University, surpassing the target of$1.3 billion by about 25 percent. CBS' campaign total is$12,060,143, which is double the College's goal.

"All ranks of donors, from large corporations to recentgraduates, have shown their support in heartwarmingfashion,” says Bob Elde, dean of CBS.

The largest contributions from area corporationshave changed the landscape—quite literally—of CBS. Among the generous gifts bestowed by Cargill,Incorporated was $10 million toward the recently

opened, $20 million Cargill Building for Microbial and Plant Genomics on the St. Paul campus, whichwill house groundbreaking research and world-class faculty. Half of this gift and $1 million for theCargill Chair in Systems Biology of HumanMetabolism are reflected in CBS' campaign total.

3M has contributed $15 million toward CampaignMinnesota, which includes $6.2 million to endow fellow-ships for students in the life sciences and engineering.The fellowship gift, matched by the University’s 21stCentury Graduate Fellowship Endowment, will support48 graduate students a year—many of whom are likelyto be CBS graduate students.

These multi-million-dollar gifts “really set the agendain terms of where we’re going to go and how fast we’regoing to get there,” says Dean Elde. But equally impor-tant to the health and prosperity of CBS are the manysmaller gifts from alumni and friends that supportundergraduate student scholarships, special programs,and other needs of the college.

“Sometimes our donors get the message that the only

important gifts are the big ones they hear about on TV

or read about in the newspaper,” says Janene Connelly,

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Jon Ross Undergraduate Scholarships

For Jon Ross, the College of BiologicalSciences and the financing of a collegeeducation are both highly personal.Ross, who has degrees in zoology (B.S.,’75), biology (M.S., ’78), and zoologyagain (Ph.D., ’96)—all from theUniversity of Minnesota—is the residentbiologist at Itasca Biological Station andLaboratories and has worked theresince 1983.

In addition, Rosshas two college-aged children—one currently in gradschool and the other planning on college after a militarystint. Ross is acutely aware of the rising burden on CBSstudents for tuition, and is doing his best to help by contributing to under-graduate student scholarships as well as the dean’s flexible general fund.

“I really hate to see students coming out of college having to pay loans for halfof the rest of their lives,” says Ross. “It feels like it’s time to start giving back.”

David Bernlohr Dean’s Strategic Initiatives FundDavid Bernlohr’s father was a professor at theUniversity, which meant that the junior Bernlohr—now a Distinguished McKnight Professor and headof the Department of Biochemistry, MolecularBiology, and Biophysics—spent a lot of time at theUniversity “going to Gopher football and basketballgames and things like that,” he says.

Given Bernlohr’s18 years at theUniversity, hejumped at thechance to be aparticipant in Campaign Minnesota and

donate, through payroll deduction, to the dean’s fund in CBS.

“I have a good sense of how important unrestricted gifts are to any academic unit,particularly when it’s not always possible to see where dollars are needed,” saysBernlohr. “We always have to be looking for what’s coming around the corner anddown the pike” in terms of new initiatives, he adds, “and I felt that unrestrictedgifts were the best way for the college to respond to new opportunities.”

Jon Ross, Itasca resident biologist

10 C O L L E G E O F B I O L O G I C A L S C I E N C E S

until recently the director of development and

external relations at CBS. “This college

depends on the donor who can make a gift

each year—whether it’s $25 or $2,500.

They’re all important.”

They’re likely to grow increasingly important.

Nationwide, with a majority of states facing

budget deficits, public funding for higher

education has flattened or, in many cases,

declined. The University will be operating in

fiscal years 2004–05 with $196 million less

in state funding than the previous biennium,

and the percentage of state support for the

U has decreased from one-third to approxi-

mately 26 percent. This has forced the

University to raise tuition by a double-digit

percentage for the third straight year, inten-

sifying the burden on students. And it cre-

ates a model in which public funding can no

longer be relied upon to keep pace with the

rising costs of higher education.

“I think private support is absolutely critical

for students,” adds Elde. “The affordability

of coming to the University is being com-

promised by our need to raise tuition.”

David Bernlohr, CBSdepartment head

Thank You continued from page 9

“It feels like time to startgiving back.”

Melinda Buck, CBS scholarship recipient

“The best way for the College torespond to newopportunities.”

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eet just a few of the people who have helped makeCampaign Minnesota a success at the College ofBiological Sciences. There are many others whose

generosity has made a difference. Although the campaign isover, the need for scholarship support continues.

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Jean ParmeleeUndergraduate Scholarships,Breckenridge Chair, ItascaAthletic FieldTalk to Jean Parmelee for a few minutes and you’llget a sense of the deep love she carries for her latehusband David and, by extension, the University ofMinnesota. They were together for nearly 60 yearsand lived and worked from the Arctic to theAntarctic in line with David’s career as a polarornithologist. He was director of the Itasca

Biological Station from 1970-1986 and served on theBell Museum of Natural History faculty for severalyears.

They started giving to the College of BiologicalSciences years ago, and Jean is continuing theParmelee legacy of generosity. She recently

increased her monthly contributions to the David F. and Jean M. Parmelee MemorialScholarship to elevate the fund to $10,000. Previously, she donated $10,000 to reno-vate and upgrade the recreational fields at Itasca that bear the family name. Prior tothat, the Parmelees gave to small scholarship funds at the College and also con-tributed $10,000 for the Breckenridge Chair in Ornithology.

“As long as I live, I’ll be sending money to the Parmelee Memorial Scholarshipfund,” Jean says. “I give mostly because it’s a memorial to David, who was greatlyattached to the University of Minnesota,”

“Once again,” she stresses, “to honor my husband, I would do anything.”

Denny and Joan DvergstenHeritage Society BequestDenneth (Denny) and Joan Dvergsten consider theirgifts to the University a form of voluntary self-taxa-tion. “Individuals have to try to do what they can insmall ways to help our students alleviate the bur-den of tuition,” says Denny.

Denny spent his career in the biological scienceshelping students, first as a high school biology

teacher (he wasselected MinnesotaTeacher of the Year in1975) and as CBS outreach coordinator from 1986-1991.

Now, the Dvergstens are assuring that their assis-tance to students will carry on well into the future;

they’ve left a generous Heritage Society bequest for the College in their will.

“I think giving is a way of leaving some sort of a footprint,” says Denny, “and Ithink leaving a legacy to a school is leaving some impact of yourself and yourlife’s work after you’re gone.”

B I O ❙ F A L L 2 0 0 3 11

The quality of students entering CBS,

however, remains uncompromised.

Elde points out that these students

are asking themselves, “‘Should I go

to Stanford, Princeton, Michigan, or

Minnesota?’ That’s our competition.

Our tuition is lower than any of these

schools, but they’re certainly getting

financial aid offers from these institu-

tions. The question is, can they get any

financial aid from us?… “We won’t be in

the market for them to become our

students unless we can offer them

competitive financial aid packages,

including scholarships.”

So although Campaign Minnesota is nowofficially completed, the need for privatesupport continues. CBS remains a rela-tively young college at the University,and its scholarship and fellowshipendowment is still well short of Elde’sgoal of $10 million. Increasing thisendowment is critical to attracting topstudents. Currently, CBS is able to offerapproximately 70 scholarships and fel-lowships each year—a number that willhave to increase to keep pace with thegrowing number of applicants in need.

The college is aware of and heartened bythe fact that many of its donors are ofmodest means, yet committed to pavingthe way for tomorrow’s students. Donorshave the opportunity to assist first-gener-ation students like Melinda Buck, a gradu-ate in genetics, cell biology, and develop-ment, who received the Biological SciencesAlumni Society scholarship and the PaulMorris Scholarship. Donors are invited tomeet students at the annual DonorRecognition and Appreciation Dinner.

In addition to Cargill and 3M, “Our giftscome from very modest families and individ-uals,” Connelly notes. “You don’t have to bewealthy to be philanthropic.”

—Rick Moore

Jean Parmelee, widow of DavidParmelee, CBS professor

Biology teacher Denny Dvergstenand his wife, Joan Dvergsten

“I give as a memori-al to David, whowas very attachedto the University.”

“We want to helpalleviate the bur-den of tuition forstudents…and toleave a legacy.”

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C O L L E G E O F B I O L O G I C A L S C I E N C E S12

ammals,” says SharonJansa, “you know they’reout there, but unlike

birds they often can’t be seen.” ForJansa, an assistant professor inthe Department of Ecology,Evolution, and Behavior (EEB),studying mammals is akin to hunt-ing for hidden treasure. “It’sthrilling to discover what’s there,”she says. Although species aredeclining worldwide, Jansa pointsout that it is impossible even tomeasure the loss of species diver-sity without first understandingwhat species are present, wherethey live, and how they are related.

In her pursuit of such discoveries,Jansa has weathered typhoon sea-

son in Madagascar, climbing treesand lashing traps to branches inorder to capture arboreal rats.More recently, she and a group ofundergraduate students havestalked the wilds of Itasca StatePark to improve their trackingtechniques. Jansa has been fasci-nated by mammals since herundergraduate days at Berkeley,when she thought she wouldbecome a vet. Then, an independ-ent study project introduced her toscientific research. “I discoveredthe morphological complexity ofmammals and the adaptationsthey exhibit, and this reallyappealed to me,” she says. Today,she studies the evolutionary rela-tionships among rats inMadagascar and marsupials inSouth America. Most of her worktakes place in the laboratory,where she analyzes DNA.

Because her own work depends onspecimens collected in the field,Jansa was particularly interestedin a job that combines teachingwith managing a scientific collec-tion. “There are very few jobs thatoffer both,” she says. At theUniversity, where she joined thefaculty last September, Jansa isalso curator of the Bell Museum ofNatural History’s extensive mam-mal collection. “It’s very hard toteach a mammalogy course with-out a specimen collection,” shesays. “It’s like having a good lend-ing library on campus versus hav-ing to depend on interlibrary loan.”

Luckily, the museum offers bothbreadth and depth in its collec-tions. “It’s a fabulous record of

local biodiversity,” says Jansa.“This data is critical to Minnesotans—we can look at the collection toobtain a wide range of information,such as how the distribution ofspecies is changing over time.”

Jansa’s joint commitments to EEBand the Bell Museum are typical ofa longstanding partnershipbetween the two units. “When wework with a top flight departmentlike EEB, in a college with a num-ber of specialties, it allows us tosee a bigger picture and stay onthe cutting edge,” says BellMuseum Director Scott Lanyon.“Other large museums have astrong focus in systematics [thestudy of the tree of life] but wehave the opportunity to interactwith experts in ecology, behavior,and many other fields.” In addition,Bell Museum faculty teach coursesin whole-organism biology, suchas mammalogy and ornithology.“The vast majority of courses thatintroduce students to differentparts of biodiversity are taught byBell Museum faculty,” saysLanyon.

Jansa will teach her first course,Introduction to Mammalogy, in thefall. Students will learn to identifyevery mammal species inMinnesota by skull and skin—andalong the way, Jansa hopes theywill also become inspired by thevast diversity of mammals and theevolutionary forces that haveshaped them.

—Jennifer Amie

“Studying mam-

mals is akin to

hunting for hidden

treasure. It’s

thrilling to discov-

er what’s there.”

—Sharon Jansa

Sharon Jansa, assistant professor of ecolo-gy, evolution, and behavior, with a newfriend from the Bell Museum, where she iscurator of mammals.

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Tracking mammalsfrom Madagascar to Minnesota

“M

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oday, scientific innovationoften occurs at the bound-

aries between disciplines. As aone-man interdisciplinary team,Michael Flickinger is in an idealposition to capture it. Primarily amicrobial biochemist, Flickingeralso qualifies as a materials sci-entist and chemical engineer andhas spent his career at the inter-face between microbiology andbiochemical engineering.

Recruited in 1985 from theNational Cancer Institute, wherehe directed the fermentation pro-gram, to become founding directorof the Biotechnology Institute,Flickinger now devotes his time tohis own research program – devel-oping novel ways to use bacteriaas industrial catalysts.

Flickinger begins by tapping theability of bacteria to transformmolecules, make essential aminoacids and other nutrients, anddetect pollutants. Then he com-bines living bacteria with newcomposite materials to maximizethe potential for desired chemicalreactions.

“We really haven’t changed theway we use bacteria in industry incenturies,” he says. “Now, mostindustrial chemical processes arecatalyzed on surfaces, for exam-ple, catalytic converters.” Whynot, he says, do the same withbacterial catalysts?

With that thought in mind,Flickinger and his colleagues havecreated several unusual hybridtechnologies. For example, hecombines bacteria with synthetic

polymers to create paint and inkwith biosensing capabilities.

Some bacteria can produce hydro-gen and “fix” nitrogen from the airinto biologically useful forms.Flickinger has found a way to sta-bilize the bacteria in a matrix oflatex polymers, which form thebasis of most paints.

It’s the “world’s worst paint”because it has to be permeable toair and nutrients, Flickinger says.But the biocatalytic coatings tech-nique has great potential forbiosensors and industrial bio-catalysis.

If he can extend the length of timebacteria live in the paint, bacterialcatalysts could be competitive withchemical production of hydrogenand usable nitrogen and “the useof bacteria in the chemical indus-try would explode,” he says.

In another project, Flickinger andNorwegian scientists are develop-ing a bacterium that has beenengineered to produce the essen-tial amino acid L-lysine frommethanol (methyl alcohol).Isolated by CBS scientists fromMinnesota lake water, the bacteri-um grows in sea water. L-lysine iscurrently fermented from sugarand used as a nutrient for humansand livestock. Since 1986, globaldemand for lysine has more thanquintupled. Flickinger’s idea is tomake methanol from the naturalgas normally burned off at oilwells, then feed it to the bacteria.This could also be a useful sourceof protein for large-scale remoteaquaculture.

“If we can make L-lysine frommethanol, we won’t have to clearjungles just to grow crops to getsugar to make lysine,” he says.

Flickinger and his colleagues havealso coated integrated circuits withliving bacteria that respond tomercury, producing a sensor thatcan detect mercury in water orfish tissue. Someday, anglers mayuse the sensor in a needlelikeprobe to check a fish’s mercurycontent before deciding whether tokeep it. The technology could alsobe extended to other pollutants, ingasses and liquids.

—Deane Morrison

At the interface between microbiologyand biochemical engineering

MichaelFlickingerembeds bacte-ria in compos-ite multilayerlatex coatingsto createbiosensors fordetecting con-taminants inwater, soil,and air. TI

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B I O ❙ F A L L 2 0 0 3 13

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A ss aa CCBBSS aalluummnnuuss,, wwhhaatt ddoo yyoouu wwaannttffrroomm tthhee ccoolllleeggee??

You may get a call from Mervyn de Souzathis fall asking you that very question.

As the new president of the BiologicalSciences Alumni Association (BSAS), de Souza’s priority will be to build alumniengagement. He firmly believes that beginsby personally asking alums what they wantfrom CBS. So when the board reconvenesthis year, they may be dialing your number.

If you do happen to get de Souza on thephone, you will likely get a dose of the

energy and zeal he brings to his newrole.

"Mervyn has a rare combination of cre-ativity, drive, and a sense of wonderabout what nature holds in store forus," says Larry Wackett, professor ofmicrobial biochemistry and de Souza'sgraduate adviser. "He's the kind of per-son you just like to be around."

Because of the College’s limited budgetand everyone’s limited time, de Souzathinks it makes sense to hold one bigalumni event a year rather than severalsmaller events. He suspects that whatalumni really want is an event thatkeeps them updated on research at thecollege and beyond, while offering networking opportunities and somefun. He’s looking forward to hearingwhat you think about that.

De Souza also would like to see theboard (“an incredible team of diverse andtalented people”) become more involved inthe life of the college and advise the deanon strategic directions. “As biologists inthe workforce, we have a lot to con-tribute,” he says.

Working to improve the undergraduateexperience will remain a priority, de Souzaadds. Board members and volunteers willcontinue mentoring undergrads and provid-ing career guidance. But he wants to broad-en that effort to include graduate studentswho, he says, are less likely to feel like partof the CBS community and to remain con-nected to the college as he has.

Born and raised in Bombay, India de Souzacame to CBS as a graduate student in the1990s and spent several years here earningan M.S. in microbiology and a Ph.D. in bio-

chemistry. He met his wife, JenniferSeffernick, in Larry Wackett’s lab, whereshe continues as a postdoctoral researcher.The research he did at CBS enabled deSouza to land a job as a principal scientistin Cargill’s Biotechnology DevelopmentCenter, where he works on using microbialbiotechnology to develop new products andimproved processes for food, feed, and bio-based materials.

“I have had a long and very fruitful relation-ship with the college and want that to con-tinue,” he says. “So it was an obviouschoice to me to join BSAS. I’d like to helpother students and alumni have that kind ofrelationship with CBS.”

—Peggy Rinard

Join the College of Biological Sciences onNovember 1 to cheer for the Gophers asthey take on the Indiana Hoosiers at theMetrodome. CBS will host tailgatingbefore the game in the parking lot.

Tickets for the game (seats in the upperendzone) and tailgating are $15; ticketsfor tailgating alone are $4. To order, contact Emily Johnston at 612-624-4770 or [email protected], or go to

www.cbs.umn.edu and follow the Alumni &Friends links. Orders must be in by October10, 2003. Check the Web site in earlyOctober to confirm the date.

New BSAS president wants to know what you want from CBS

"Mervyn has a rare combination

of creativity, drive, and a sense

of wonder about what nature

holds in store for us," says

Larry Wackett, professor of

microbial biochemistry and

de Souza's graduate adviser.

"He's the kind of person you just

like to be around."

Homecoming 2003

14 C O L L E G E O F B I O L O G I C A L S C I E N C E S

Mervyn de Souza, new BSAS president, is a principalscientist at Cargill, Inc.

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B I O ❙ F A L L 2 0 0 3 15

GGrreeggoorryy LLeeee (B.S. in Botany, 1975) and his familymoved this summer to Salt Lake City, where hehad been named executive director of Red ButteGarden and Arboretum at the University of Utah.Lee was formally a development specialist at theUniversity of Minnesota Foundation.

TToomm CCaarrllssoonn (Ph.D. in Zoology, 1977) has been atPacific Lutheran University in Tacoma,Washington since 1975. He was chair of biologyfor nearly a decade, and is currently the Dean ofNatural Sciences.

LLiinnddaa EEeellllss (B.S. in Biology, 1984, M.S. inConservation Biology, 2000) was hired as anassistant librarian for social sciences/science inMagrath Library on the University of MinnesotaSt. Paul campus in January, 2003.

DDeeaannnnaa HHaarrkkiinnss,, (B.S. in Genetics and CellBiology, 1986; M.D., 1992; and M.P.H. inEnvironmental Health, 1999) moved to Bel Air,Maryland this past year, leaving her position atthe Centers for Disease Control in Atlanta.Deanna now works with the United States ArmyCenter for Health Promotion and PreventiveMedicine in the Occupational and EnvironmentalMedicine Program.

TTaammmmyy MMccIInnttyyrree (B.S. in Genetics and CellBiology, 1988) completed the M.Ed. in HumanResource Development from the College ofEducation and Human Development this pastyear. After 12 years in research and developmentwith the Pillsbury Company, she will be transi-tioning into a role at General Mills that focuseson organization development.

DDaavviidd SSiimmoonnssoonn (B.S. in Biochemistry andMicrobiology, 1988) and JJuulliiee SSiimmoonnssoonn (Ph.D. inFood Sciences, 1990) are relocating to Germanyfor two to three years because of Julie’s positionin research and development at Kraft Foods.David has been a stay-at-home father for the lastsix years. They will be living in the Munich areaand enjoying the people, travel, and culturalofferings of Europe.

DDaavvee KKeettttnneerr (B.S. in Genetics, Cell Biology, andDevelopment, 1993) recently took a new positionat the Wisconsin Alumni Research Foundation asthe Assistant General Counsel in the Patents andLicensing Department.

SSaattiinnddeerr SSiinngghh (B.S. in Biochemistry, 1995; Ph.D.in Biochemistry, Molecular Biology, andBiophysics, 2002) is a postdoctoral fellow in thelaboratory of Dr. J. Eric Gouaux in theDepartment of Biochemistry and MolecularBiophysics at Columbia University. He started inthe lab last October and has been studying thestructure/function relationships in ionotropicglutamate receptors.

CCuurrtt HHeennrryy (B.S. in Biochemistry, 1996) and hiswife, Lisa, welcomed their son Alex into theworld this past April.

HHeeiiddii TThhoorrssoonn (B.S. in Biochemistry andGenetics, Cell Biology, and Development, 1998)recently graduated from the University of SouthDakota School of Medicine. She began herOB/GYN residency in St. Louis in June at theWashington University/Barnes Jewish Hospital.

KKyyllee RRuueesscchh (B.S. in Microbiology, 2000) is anassistant research microbiologist in fermentationprocess development at Bio-Technical Resourcesin Manitowoc, Wisconsin.

TTrraavviiss MMoooorree (B.S. in Biology, 2001) recentlyaccepted a teaching position at Stockbridge HighSchool in Stockbridge, Wisconsin. He will beteaching all areas of science as well as coachinggirls’ softball. Stockbridge is a small school withonly 90 students.

MMaarrkk JJaannzzeenn (Ph.D. in Biochemistry, MolecularBiology, and Biophysics, 2002) left his position asa senior scientific services specialist at theNational Marrow Donor Program and is now theDirector of Laboratory Medicine at MemorialBlood Centers in Minneapolis.

AAddrriieennnnee KKaarrii (B.S. in Biochemistry, 2002) willbegin the Environmental Epidemiology Programin the School of Public Health at the University ofMichigan, Ann Arbor this fall.

RRyyaann SScchhuullttzz (B.S. in Biochemistry, 2002) wasaccepted at the University of Cincinnati LawSchool and will begin this fall.

KKaatthheerriinnee NNiikkssiicchh (B.S. in Biology, 2003) willbegin veterinary school at Michigan StateUniversity in East Lansing this fall.

BBoobbbbii SSiisslloo (B.S. in Genetics, Cell Biology, andDevelopment, 2003) has been accepted at theSchool of Pharmacy at the University ofMinnesota and will begin this fall.

BBeetthh TThhiieelleenn (B.S. in Microbiology, 2003) hasjoined the Medical Scientist Training Program(M.D./Ph.D. dual degree) at the University ofWashington in Seattle.

IInn MMeemmoorriiuummWWaallllaaccee RR.. RRooyy (Ph.D. in Biochemistry, 1941) aformer vice president of technical services forMinute Maid Co., died in June. He helped developthe process for making frozen concentratedorange juice as well as Coca-Cola beveragesFresca and Fanta. He was 97.

If you have a class note, please contact Emily Johnston at 612-624-4770 [email protected].

Biological SciencesAlumni Society2003-2004 Board of DirectorsMMeerrvvyynn ddee SSoouuzzaa,, PPrreessiiddeennttM.S. Microbial Engineering, 1997Ph.D. Biochemistry, MolecularBiology, and Biophysics, 1998

JJaannee JJoohhnnssoonn,, PPrreessiiddeenntt--EElleeccttB.S. Biology, 1976

PPhhiillll LLaawwoonnnn,, PPaasstt--PPrreessiiddeennttB.S. Microbiology, 1984

KKiipp TThhaacckkeerr,, NNaattiioonnaall BBooaarrddRReepprreesseennttaattiivveeB.S. Microbiology, 1976Ph.D. Microbiology, 1984

CCaarroollyynn BBaaggnneeB.S. Biology, 1997

JJeeffff CCaarrppeenntteerrPh.D. Cell and DevelopmentalBiology, 1991

BBiillll DDiieekkmmaannB.S. Biology, 1987

JJeennnneeaa DDoowwB.S. Biology, 1999

CCuurrtt HHeennrryyB.S. Biochemistry, 1996

RReebbeeccccaa MMaarrrrss EEiiddeeB.S. Biochemistry, 2001

DDoouuggllaass PPrraattttB.S. Natural Science, 1952M.A. Botany, 1959Ph.D. Botany, 1960

JJeennnniiffeerr SSeeffffeerrnniicckkPh.D. Biochemistry, MolecularBiology, and Biophysics, 2001

TTiimm VVoolllleerrB.S. Biology, 1984

Class Notes

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16 C O L L E G E O F B I O L O G I C A L S C I E N C E S

Kip Thacker credits theeducation he got at CBSfor launching his suc-

cessful career in biotechnology.So when Dean Elde asked him toshare his experience as a mem-ber of UMAA’s national board, hereadily agreed.

“The University is very importantto me personally and to the stateof Minnesota,” says Thacker, whois Director of New BusinessDevelopment for Lifecore, Inc. inChaska. “I’m willing to pitch in

and help support it in any way Ican.”

Thacker has a long history ofinvolvement with CBS. Just afterreceiving his Ph.D., he helpedDenny Dvergsten with an out-reach program for high schoolstudents. He was president ofthe Biological Sciences AlumniSociety for a year. And he servedon the CBS Advisory Board whenPete McGee was dean.

“I was delighted that Kip accept-ed,” Elde says. “His biotechnolo-gy career, involvement withalumni activities, and leadershipskills made him our number onecandidate.”

One of Thacker’s goals will be topromote the University’s efforts toexpand the biotechnology industryin Minnesota. As a board mem-ber, he hopes to have opportuni-ties to speak with legislators andto increase public awareness ofpotential benefits for Minnesota.

Thacker earned a B.S. degree inmicrobiology from CBS in 1976and a Ph.D. in 1984. He joinedLifecore in 1981, when it wascalled Diagnostic, because heknew Jim Bracke, now Lifecore’spresident. At the time, Diagnosticwas a small company in Rosevillethat produced culture media forclinical laboratories. Bracke andThacker invented a way to pro-duce medical grade hyaluronan, aviscous substance now widelyused in cataract surgery, by fer-mentation of microbes. Thacker isnow working with customers to

develop new applications forhyaluronan, which is Lifecore’stop-selling product. It’s also usedto treat symptoms of osteoarthri-tis, as a component in bone-graft

pastes, and coatings of catheters.The company has an OralRestorative division, which sells aline of dental implants.

“Lifecore is a cross between abiotech company and a medicaldevice company because hyaluro-nan is made using biotechprocesses but is regulated as adevice. In the future it’s likely tobe used as a drug. The growth ofbiotechnology in Minnesota isimportant to me because biotechcompanies need a critical mass ofother biotech companies tothrive,” Thacker says.

“I want to help the Universitythrive by ensuring that it has thepublic support and resources toattract top quality students andfaculty. A strong University willprovide innovative new ideas aswell as qualified employees forMinnesota’s growing biotechcommunity.”

—Peggy Rinard

CBS rep to the UMAA National BoardMeet Kipling Thacker

Kip Thacker is Director of New Business andDevelopment for Lifecore,Inc., which makes biolog-ical products used inhealth care.

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One of Thacker’s goals

will be to promote the

University’s efforts to

expand the biotechnology

industry in Minnesota.

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B I O ❙ F A L L 2 0 0 3 17

olly Koslowski loves biology. She also loves

working with youth. This fall theCBS undergraduate will get herfill of both as a participant inScience Education Partnershipfor Greater Minnesota (SEPGM), anew mentorship program thatgives students a chance to spenda semester one-on-one with middle and high school scienceteachers in northwesternMinnesota.

SEPGM has its roots in a conver-sation between CBS dean RobertElde and Steven Yussen, dean ofthe College of Education andHuman Development. Observingthat many Minnesota scienceteachers are approaching retire-ment, the two began brainstorm-ing ways to encourage a newgeneration to take up the torch.Need led to vision, vision—withinput from educators and schooladministrators—led to plan, andplan led to a $1.7 million grantfrom the Howard Hughes MedicalInstitute to carry it out.

Coordinator Ken Jeddeloh, whohas 38 years’ experience in K–12science education, notes the pro-gram benefits all involved. “Forour undergraduate students,there’s an opportunity to investi-gate a career option. For theteachers, the ability to attendworkshops is a real payoff. Forthe school district, there’s theopportunity to entice a student tobe a teacher in their district. Thecommunity wins as well. And italso helps the U by showing that

we are extendingourselves in the K-12 curriculum,” hesays.

“As biologists, welook at this programas tending the gar-den: planting newseeds, providing agood environmentfor these seeds togerminate andgrow, and providingnourishment for theperennial plantsalready in the gar-den. As educators,we view this pro-gram as a means tocreate a new partner-ship that brings post-secondaryscience teaching and learningdirectly into rural classroom set-tings. . . . And as both biologistsand educators, we expect to learnmore about the ‘ways of knowing’through the collaborations set uphere,” Elde noted in the grantproposal.

This year’s SEPGM students beganworking on directed research proj-ects in the Twin Cities in June togain research experience. In July, a half dozen student-mentor pairs spent a week at the ItascaBiological Station and Laboratoriesgetting to know each other andpreparing for the semester ahead.Teachers also received lessons inmentoring and were introduced totechnologies, including gel elec-trophoresis and fluorescencemicroscopy.

Koslowski’s mentor, CandidaBraun of Grand Rapids HighSchool, says she’s looking for-ward to the perspectiveKoslowski will give her on hercurrent classroom practices.

“I think it’s going to be a goodlearning experience for me,” shesays. “This will be a means tohelp me grow professionally.”

The high school students willbenefit from special educationalopportunities at Itasca and in theTwin Cities.

Program developers hope to havetwice as many student/mentorpairs on board next year. The goalis to be self-sustaining by thetime the grant runs out in 2006.

—Mary K. Hoff

“As biologists, we

look at this pro-

gram as tending

the garden: plant-

ing new seeds,

and providing a

good environment

for these seeds to

germinate and

grow.”

—Dean Elde

CBS student Holly Koslowski, right, with her mentor Candida Braun, a biology teacher atGrand Rapids High School, at Itasca this summer.

KEN

JED

DEL

OH

Planting the next generationof K-12 biology teachers

H

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18 C O L L E G E O F B I O L O G I C A L S C I E N C E S

1930sCCllaauuddee HH.. HHiillllss MMMMaaxx AA.. aanndd EErriikkaa EE.. LLaauuffffeerr MMEEddwwaarrdd BB.. aanndd PPaammeellaa HH.. LLeewwiissPPaauull EE.. RRaammssttaadd

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PPhhiinnnneeyy MMFFrraannkk WW.. PPuuttnnaamm NNaatthhaann SSppeerrbbeerr

1950sAAaarroonn WW.. BBuurrcchheellll MMiillttoonn HH.. FFiisscchheerr MMWWiilllliiaamm HH.. HHaarrrriissoonn MM

RRoobbeerrtt CC.. HHooddssoonn MMMMaarrjjoorriiee HH.. aanndd BBrruuccee LL..

LLaarrssoonn MMOOrrllaannddoo aanndd GGlloorriiaa

RRuusscchhmmeeyyeerr MMKKiinnggsslleeyy RR.. SStteerrnn DDoorrootthhyy BB.. aanndd MMeellvviinn PP.. SSttuullbbeerrggCC.. IIvvaarr TToolllleeffssoonn MMJJaanniiccee MM.. aanndd CCuurrttiiss MM.. WWiillssoonn MM

11996600ssAArrlleennee MM.. aanndd GGaarryy AA..

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LL.. KKiirrsscchhnneerr JJoohhnn AA.. MMaayyoo MMRRiicchhaarrdd HH.. NNoorrtthhrruupp AAmmyy OOggaanneekkuu JJaammeess BB.. aanndd JJooaann CC.. PPeetteerr DDoouuggllaass CC.. aanndd BBeevveerrllyy AA..

PPrraatttt MMHH.. GGeerrrriitttt RRoosseenntthhaall LLaarrrryy JJ.. aanndd SShhaarryynn MM..

SSaallmmeenn MMMMaarrcciiaa MM.. TThhoolleenn MMJJeeaanneettttee AA.. WWiillttssee

11997700--11997744LLyynnddaa aanndd GGaarryy AAcckkeerrtt MMPPhhiilliipp AA.. BBaallaazzss MMCCiinnddyy JJ.. BBrruunnnneerr MMMMoonniikkaa aanndd KKeeiitthh BBuurraauu SSuussaann MM.. aanndd JJoohhnn TT.. CCaappeecccchhii RRoobbeerrtt WW.. CChhrriisstteennsseenn,, JJrr.. KKoooo HH.. CChhuunngg MMiicchhaaeell FF.. CCooyyllee MMCCoonnssttaannccee FF.. DDaanniieellssoonn JJeeffffrreeyy TT.. DDee ZZeellllaarr MMSShhaayynnee EE.. DDiizzaarrdd aanndd WWiilllliiaamm HH..

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WWaallkkeerr MMMMaarryy TT.. aanndd DDoouuggllaass JJ.. OOllssoonn MMJJeeffffrreeyy EE.. PPeeaarrccee JJaammeess JJ.. PPeeaarrssoonn MMWWiilllliiaamm aanndd SSuuzzaannnnee PPeeggllooww MMDDaallee WW.. PPeerrmmaann LLaarrrryy PPuucckkeetttt CChhaarrlloottttee MM.. aanndd WWiilllliiaamm PP..

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1975-1979KKeenntt JJ.. aanndd SSuussaann HH..

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M membership in the University of Minnesota Alumni Association/Biological Sciences Alumni Society

ur sincere appreciationto all of our donors andcorporate/organization-

al partners. Your contributionto the College of BiologicalSciences during fiscal year2003 will have a long-lastingeffect. Together we can ensurethat current and future gener-ations of students will experi-ence high quality education.Every gift makes a difference.

If your name is missing orincorrectly listed, please notifyus by calling 612-625-7705 oremail [email protected].

O

Kenji Takamura, Sarah Endrizzi, and ChuckHernick were among 273 students who gradu-ated from CBS last year. Sarah graduatedmagna cum laude. Chuck was a graduationspeaker.

Many students take advantage ofsummer classes at Itasca BiologicalStation and Laboratories.

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B I O ❙ F A L L 2 0 0 3 19

AAnnnnaammaarriiee BBeecckkeellRRooddnneeyy aanndd BBeetthh KKuueehhnn RRoobbeerrttaa KK.. LLaammmmeerrss--CCaammppbbeellll RRiicchhaarrdd PP.. LLaammppee LLeeoo GG.. LLeehhmmiicckkee JJaannee SS.. LLeevvyy NNaannccyy GG.. LLiilllleehheeii NNaannccyy OO.. aanndd DDaanniieell HH..

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AArrnneessoonn MM

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SSiieeggffrriieedd JJuulliiee AA.. aanndd DDaavviidd RR.. SSiimmoonnssoonn

JJoohhnn GG.. SStteeiieerrtt MMDDiiaannee RR.. SSttoorrvviicckk GGaarryy AA.. SSttrraanndd DDoouuggllaass aanndd SSeelleennee SSwwaannssoonnRRaannddaallll MM.. TThhoommppssoonn MMaarrkk AA.. TToommaaii MMMMaarrggaarreett MM.. WWaallkkeerr KKaatthheerriinnee MM.. WWaallssttrroomm DDaavviidd AA.. WWaalltteerrss SShhyyee--RReenn YYeehh MMJJooaannnn LL.. YYoouunngg JJaammeess JJ.. YYoouunnggbblloomm LLaauurriiee ZZeemmppeell FFoorrssyytthhee JJiillll LL.. ZZuulllloo

M membership in the University of Minnesota Alumni Association/Biological Sciences Alumni Society

Goldy Gopher leads a parade to celebrate facultyand staff contributions to Campaign Minnesota.

UM

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20 C O L L E G E O F B I O L O G I C A L S C I E N C E S

1990-1994MMiicchheellllee LL.. BBiieerrmmaa AAnnddeerrssoonn aanndd

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SSccootttt RR.. LLaarrssoonn MMZZhhaannggiiaanngg LLiiuu aanndd DDoonnyyaa GGaaoo MMMMaarryy JJoo LLoocckkbbaauumm MMCChhaadd MM.. LLuunndd BBrraaddlleeyy DD.. LLuutthhii KKrriisstteeffoorr RR.. LLyyssnnee EElliizzaabbeetthh AA.. MMaattzzkkee JJoohhnn EE.. MMaazzuusskkii AAnnddrreeww JJ.. MMcc CCuulllloouugghh MMCChhrriiss LL.. MMccLLaaiinn CChhrriissttoopphheerr DD.. MMeennttzz MMeelliissssaa AA.. OO’’DDoonnnneellll DDaawwnn MM.. OOllssoonn TTrruuddyy LL.. aanndd LLaannccee DD.. OOllssoonn MMCChhrriissttiinnee aanndd DDaavviidd OOsstteennddoorrff MMEErriicc RR.. aanndd SSuuzzeettttee EE..

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1995-1999LLoorrrraaiinnee BB.. AAnnddeerrssoonn MMRRoobbeerrtt AAsscceennzzii DDaavviidd BBaabbccoocckk CCaarroollyynn LL.. BBaaggnnee MMJJaanniiccee AA.. BBaakkeerr KKaallllii--AAnnnn LL.. BBiinnkkoowwsskkii TTaarraa RR.. BBrraattllaanndd PPaauull CC.. BBuurrkkhhoouussee MMAAnnddyy WW.. CCoolllliinnss LLeesslliiee DD.. DDee RRoouuiinn MMMMeerrvvyynn LL.. ddee SSoouuzzaa MMJJeennnneeaa DDooww aanndd SStteevveenn BBoottttss MM

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M membership in the University of Minnesota Alumni Association/Biological Sciences Alumni Society

Bob Zink, professor of ecology, evolution, and behavior, leads a bird-watchingclass at Itasca Biological Station and Laboratories.

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Professor Richard Poppele leads a neuro-science lab class at Itasca this summer.

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123 Snyder Hall1475 Gortner AvenueSt. Paul, MN 55108

Nonprofit Org.U.S. Postage

PPAAIIDDMpls., MN.

Permit No. 155

CBS Calendar

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CCaammppaaiiggnn MMiinnnneessoottaa CCeelleebbrraattiioonnCelebration of the successful completionof Campaign Minnesota, September 13,5:30 to 10:30 p.m., Coffman Union andNorthrop Auditorium. Visit www.campaign.umn.edu for details.

CCBBSS AAwwaarrddss aanndd RReeccooggnniittiioonn DDiinnnneerr Annual event to recognize scholarshiprecipients and their benefactors,Thursday, October 2, 5:30 to 8:30 p.m.,Memorial Hall, McNamara Alumni Center.

HHoommeeccoommiinngg 22000033Gophers will play the Indiana Hoosiers at the Metrodome on Saturday, November 1. Join fellow alumni for tailgating before the game. To order tailgating and/or football tickets, contactEmily Johnston at [email protected] 612-624-4770.

AAfftteerr tthhee HHaarrvveesstt PPuummppkkiinn FFeessttiivvaall Fall event for alumni and families,Saturday, October 25, noon to 3 p.m.,Minnesota Landscape Arboretum.Features nature activities for children ofall ages, a pumpkin carving contest, facepainting, snacks, and self-guided tours ofthe arboretum. Cost is $5 at the gate.

MMeennttoorr PPrrooggrraamm KKiicckk--ooffffNovember 5, 5:30 p.m., Mississippi Room,Coffman. Mentors and students meet and discuss goals. Alumni who want to be mentors can still sign up atwww.alumni.umn.edu/cbsmentor.

Contact Emily Johnston [email protected] or (612) 624-4770 for more information about any of the events listed above.

Continuing Education

Master's in Biological Sciencesoffers flexibility for working adultsStacey Olson discovered the Master’s in BiologicalSciences (MBS) program while looking for a graduate program to advance her career atCargill Dow, where she is a molecular biologist in the Biocatalyst Development Center.

After a search of offerings, she didn’t find whatshe was looking for, but learned that the U’sMBS degree would allow her to design a pro-gram that met her needs. And it would allow herto do so on her own time and at her own pace.

The MBS is a professional degree programintended to help working adults expand theirknowledge of biology and acquire new skills toadvance their careers. It requires completion of 30semester credits at the 4000 level or above, including a two-credit capstone proj-ect. Several courses are offered online and participants are encouraged to do self-directed projects.

Olson, who has a B.S. in biotechnology and microbiology from St. Cloud StateUniversity, is specializing in biochemistry and bioinformatics. Last year she took acourse in microbial genomics and bioinformatics and another in enzyme mecha-nisms. This summer she completed an independent project in bioinformatics. Inthe fall she plans to take a biochemistry course.

“I love the flexibility of this program,” she says. “In a traditional graduate programyou learn things you hope to have the opportunity to use. In the MBS program, youchoose to learn things that you can use in your work.”

Many employers pay tuition costs for this program. For more information, go tohttp://www.cbs.umn.edu/biolink/mbs or call Carol Gross at 612-625-3133.

Stacey Olson, molecular biologist atCargill Dow, is an MBS student.