Ten Lectures on Evolutionary and Ontogenetic Aspects of Adaptive
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Ten Lectures on Evolutionary and Ontogenetic Aspects of Adaptive Immune Systems Thomas Boehm Max Planck Institute of Immunobiology and Epigenetics Freiburg, Germany [email protected] http://www3.iefreiburg.mpg.de/researchgroups/developmental immunology/laboratorythomasboehm/ Monday, September 2 17: 30 1. Introduction (a) Definitions (innate vs adaptive immune systems; somatic diversification; anticipatory receptor repertoire; memory formation; clonal selection; monoallelic gene expression) (b) Immune systems of prokaryotes (CRISPR/Cas system; Promethean vs Epimethean immune systems) (c) Immune systems of invertebrates (antigen receptor diversification in molluscs; somatic hypermutation; histocompatibility in tunicates; evolution of MHC system) (d) Genetic and phenotypic diversity among vertebrates: implications for immunological research (e) Summary of Lecture 1 18: 30 2. Immune responses in jawless fishes (a) Humoral response (antigen binding assays) (b) Cellular response (c) Immune effector cells (myeloid cells; lymphocytes) (d) Summary of Lecture 2 Tuesday, September 3 17: 30 3. The molecular basis of adaptive immunity in jawless fishes (a) Variable lymphocyte receptors: structure and assembly (b) Lymphocyte lineages and lymphoid organs in jawless fishes (c) Cellular interaction/antigen presentation (d) Summary of Lecture 3 18: 30 4. The immune system of jawed vertebrates: I. Cartilaginous fishes (a) B and T cell receptors: Structure and assembly; isotype switch (b) Variant forms of antigen receptors in sharks (c) Summary of Lecture 4 Wednesday, September 3 17: 30 5. The immune system of jawed vertebrates: II. Bony fishes (a) Extensive phenotypic diversity and alternative designs (b) Summary of Lecture 5 18:30 6. The immune system of jawed vertebrates: III. Amphibians and birds
Transcript of Ten Lectures on Evolutionary and Ontogenetic Aspects of Adaptive
Ten Lectures on Evolutionary and Ontogenetic Aspects of Adaptive Immune Systems Thomas Boehm Max Planck Institute of Immunobiology and Epigenetics Freiburg, Germany [email protected] http://www3.ie-‐freiburg.mpg.de/research-‐groups/developmental-‐immunology/laboratory-‐thomas-‐boehm/ Monday, September 2 17: 30 1. Introduction (a) Definitions (innate vs adaptive immune systems; somatic diversification; anticipatory receptor repertoire; memory formation; clonal selection; monoallelic gene expression) (b) Immune systems of prokaryotes (CRISPR/Cas system; Promethean vs Epimethean immune systems) (c) Immune systems of invertebrates (antigen receptor diversification in molluscs; somatic hypermutation; histocompatibility in tunicates; evolution of MHC system) (d) Genetic and phenotypic diversity among vertebrates: implications for immunological research (e) Summary of Lecture 1 18: 30 2. Immune responses in jawless fishes (a) Humoral response (antigen binding assays) (b) Cellular response (c) Immune effector cells (myeloid cells; lymphocytes) (d) Summary of Lecture 2 Tuesday, September 3 17: 30 3. The molecular basis of adaptive immunity in jawless fishes (a) Variable lymphocyte receptors: structure and assembly (b) Lymphocyte lineages and lymphoid organs in jawless fishes (c) Cellular interaction/antigen presentation (d) Summary of Lecture 3 18: 30 4. The immune system of jawed vertebrates: I. Cartilaginous fishes (a) B and T cell receptors: Structure and assembly; isotype switch (b) Variant forms of antigen receptors in sharks (c) Summary of Lecture 4 Wednesday, September 3 17: 30 5. The immune system of jawed vertebrates: II. Bony fishes (a) Extensive phenotypic diversity and alternative designs (b) Summary of Lecture 5 18:30 6. The immune system of jawed vertebrates: III. Amphibians and birds
(a) Changes of the immune system associated with tetrapod body plan (b) Innovations/ Atavisms in antigen receptor formation (c) The evolutionary history of lymphoid organs (d) Summary of Lecture 6 Thursday, September 3 17: 30 7. The immune system of jawed vertebrates: IV. Mammals (a) Autoimmunity associated with placental life style: Threat and solutions (b) Monoallelic gene expression and repertoire formation (c) Summary of Lecture 7 18: 30 8. The immune system of jawed vertebrates: III. Mammals (d) Elaboration of the immunogenome: Genes underlying cellular communication in the immune system (chemokines; interleukins etc.) (e) Alternative functions of the MHC system: immunoecology (f) Summary of Lecture 8 Friday September 3 17:30 9. Design principles of vertebrate immune systems: ontogeny through the looking glass (a) Cell lineages, lymphoid tissues, molecules (b) Immune disorders: Animal models of human disorders (c) Summary of Lecture 9 18:30 10. Questions and answers Unresolved questions in vertebrate immunology References:
