Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg,...
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Transcript of Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg,...
![Page 1: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/1.jpg)
Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma
by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring, and Peter Kloen
J Bone Joint Surg AmVolume 96(5):e36
March 5, 2014
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 2: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/2.jpg)
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 3: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/3.jpg)
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 4: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/4.jpg)
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 5: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/5.jpg)
Acute trauma for less than seven days: a focus of organizing granulation tissue with extravasation of red cells, influx of macrophages, and inconspicuous surface synovium.
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 6: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/6.jpg)
Staining for α-SMA revealed no expression of α-SMA in fibroblast-like cells; of note, smooth muscle cells located in perivascular areas stain for α-SMA indicating specificity of staining (25×).
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 7: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/7.jpg)
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 8: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/8.jpg)
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 9: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/9.jpg)
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 10: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/10.jpg)
Posttraumatic elbow contracture: fibrosis with increased dense plump collagen matrix with fibroblasts and no neovascularization (200×).
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.
![Page 11: Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,](https://reader035.fdocuments.in/reader035/viewer/2022062409/5697bfc81a28abf838ca8433/html5/thumbnails/11.jpg)
Staining for α-SMA revealed no expression of α-SMA in fibroblast-like cells; of note, smooth muscle cells located in perivascular areas did stain for α-SMA, indicating that our staining
protocol for α-SMA was specific (200×).
Job N. Doornberg et al. J Bone Joint Surg Am 2014;96:e36
©2014 by The Journal of Bone and Joint Surgery, Inc.