Templates for Course Specifications - Delta...

Department of Microbiology and Biotechnology

Courses Specifications

2017-2018

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Contents

General Microbiology ......................................................................................... 2

Pharmaceutical Microbiology ............................................................................ 7

Immunology ....................................................................................................... 12

Parasitology ........................................................................................................ 16

Pharmaceutical Biotechnology ......................................................................... 21

Public and Environmental Health ................................................................... 26

Industrial Microbiology and Biotechnology ................................................... 31

Human Rights .................................................................................................... 35

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Delta University for Science and Technology

Quality Assurance Center

Course Specifications

1. Basic Information:

Course Title: General Microbiology

Course Code: MB 201

Program on which the course is given: B. Pharm.

Department offering the course: Microbiology and Biotechnology

Academic year/ level: Spring Semester 2017/2018 Level 2

Prerequisite: General biology (PB 101)

Credit hours: Lecture: 2 Practical: 1 Total: 3

2. Course Aims:

Providing the students with knowledge about typical and atypical forms of bacteria, viruses

and fungi. Clarifies different mechanisms of transport across bacterial cell membrane,

metabolic pathways and physiology of bacteria. This course covers the principles of genetic

characters including DNA and RNA structures, replication, different forms of mutation and

mutagenic agents.

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A1

a1. Identify the basic structure of Prokaryotes cell & Eukaryotes cell.

a2. Illustrate general microbial structure (Bacteria, virus, fungus).

a3. Describe methods of microbial reproduction.

A10 a4. Describe atypical forms of bacteria.

A11

a5. Recognize the basic structure of nucleic acid, gene expression and its transfer.

a6. Identify role of different mutagens in causing mutation.

a7. Identify the nutritional requirements for different microbes.

b. Intellectual Skills:


B8

b1. Develop appropriate methods for identification of microorganisms causing

infections.

b2 Categorize microorganisms as a bacterium, virus or fungus

B17

b3. Categorize variable staining and molecular techniques to study different microbial

infections

b4. Formulate a systemic approach for laboratory diagnosis of infectious agents.

b5. Compare between DNA and RNA structure, different methods of gene transfer

and detection techniques.

b6. Develop a comparison between different mutagens

B21 b7. Interpret results of microbiological tests.

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c. Professional and Practical Skills:


C2 c1. Handle and dispose hazardous microbiological preparation safely.

C6

c2. Perform isolation and identification of microorganisms causing microbial

infections

c3.

Carry out different laboratory staining Gram stain, Ziehl-Neelsen and spore

stain and identify the microorganism according to morphology and

characteristics of stained preparations.

c4. Utilize culture media, biochemical tests commonly used for bacterial

identification and distinguish positive and negative results.

d. General and Transferable Skills:


D3 d1. Interact effectively in team working.

D10

d2. Present information clearly in written, electronic and oral forms.

d3. Perform a concise scientific activity according to standard scientific thinking

and integrity.

Contents:

3.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to cell structure (Prokaryotes & Eukaryotes) and

Bacterial nomenclature & morphology 2

2. Bacterial cell wall. 2

3. Structure of cellular appendages 2

4. Structure of bacterial cell membrane and the transport across

it.+ Quiz 1 2

5. Bacterial physiology and growth. 2

6. Atypical bacteria and bacterial sporulation 2

7. Basics of fungal structure, reproduction and lab diagnosis. 2

8. Quiz 2

9. Basics of virus structure, replication and lab diagnosis. 2

10. DNA and RNA structures. 2

11. Gene expression. 2

12. Gene transfer and transposable elements. 2

13. Types of mutations. 2

14. Final Exam

Total:

2 credit hours 15.

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3.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Lab Safety 1

2. Microscope 1

3. Simple stain 1

4. Gram stain for single bacterial isolate 1

5. Gram stain for bacterial mixtures 1

6. Pour plate technique 1

7. Acid fast stain 1

8. Quiz 2

9. Spore stain 1

10. Non selective Media (Composition, Types & Importance) 1

11. Selective and Differential Media 1

12. Revision 1

13. Practical Exam 1

14. Final Exam

Total:

1 credit hour 15.

4. Teaching and Learning Methods:

5.1. Lectures

5.2. Tutorials and seminars

5.3. Practical Classes

5. Student Assessment Methods:

5.1. Assessment methods:

1. Written exam To assess knowledge, understanding, intellectual and professional skills.

2. Practical exam To assess professional and practical skills.

3. Course work To assess knowledge, understanding, intellectual skills, general &

transferable skills.

4. Oral exam To assess knowledge, understanding, intellectual skills, general skills

and confidence.

5. Quizzes To assess knowledge, understanding and intellectual skills.

5.2. Assessment schedule:

Assessment 1 Quiz 1 4th week


Assessment 3 Assignment/activity (student presentation) all over the term

Assessment 4 Practical exam 13th week

Assessment 5 Oral exam 14th & 15th weeks

Assessment 6 Written exam 14th & 15th weeks

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5.3. Weighing of Assessments:

1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (student presentation) 5

2. Final-Term Exam 40

3. Oral Exam 10


Total 100%

6. List of References:

No. Reference Type

1. Warren Levinson 2016. Review of medical microbiology and

immunology 14th edition, New york: Mc Graw Hill medical. textbook

2. Journal of medical Microbiology. periodical

3. http://www.microbiologybook.org website

7. Matrix of course contents versus ILOs:

7.1. Lectures:

Study

week Course Contents

ILOs

K&U IS P&PS G&TS

1.

Introduction to cell structure

(Prokaryotes & Eukaryotes) and

Bacterial nomenclature & morphology

a1 b3 c2,c4 --

2. Structure of bacterial cell wall a1,a2 b3,b4 c2,c4 --

3. Structure of cellular appendages. a1,a2 b3 c2,c4 --

4. Structure of bacterial cell membrane

and the transport across it.+ Quiz 1 a1,a2 b3 c2,c4 --

5. Bacterial physiology and growth. a3,a7 b1,b2 c4 d1-d3

6. Atypical bacteria and bacterial

sporulation. a2,a4 b3 c3 d1-d3

7. Basics of fungal structure, reproduction

and lab diagnosis. a1,a2 b1,b3 c1 d1-d3

9. Basics of virus structure, replication

and lab diagnosis. a2 b3 c1 d1-d3

10. DNA structure. a5 b5,b6 c1 d1-d3

11. Gene expression. a5 b5,b6 c1 d1-d3

12. Gene transfer and transposable

elements. a5 b5,b6 c1 d1-d3

13. Types of Mutation a6 b5,b6 c1 d1-d3

http://www.microbiologybook.org/

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7.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Lab Safety ---- ----- c1 --

2. Microscope and introduction to

staining technique a1,a2 b3, b4 c1 --

3. Simple stain a1,a2 b1,b7, b4 c2,c3 --

4. Gram stain for single bacteria a1,a2 b1,b7, b4 c2,c3 d1-d3

5. Gram stain for bacterial mixture a1,a2 b1,b7, b4 c2,c3 d1-d3

6. Pour plate technique a3,a7 b1,b3, b4 c4 d1-d3

7. Acid fast stain a4,a2 b3,

b4,b5,b7 c2,c3 d1-d3

9. Spore stain a4,a2 b1,b3,

b4,b7 c2,c3 d1-d3

10. Non selective Media (Composition &

Importance) a3,a7

b2,b3,

b4,b7 c4 d1-d3

11. Selective and Differential Media a3,a7 b2,b3,

b4,b7 c4 d1-d3

12. Revision

Name Signature

Course Coordinator: Prof. Dr. Enas Hammad

Head of Department: Prof. Dr. Enas Hammad

Approval Date 3-2-2018

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Course Title: Pharmaceutical Microbiology

Course Code: MB 302


Department offering the course: Microbiology & Biotechnology

Academic year/ level: Fall Semester 2017/2018 Level 3

Prerequisite: General Microbiology (MB 201)


2. Course Aims:

The course provides the students with the knowledge and skills concerning the classification of

different antimicrobial agents (antibacterial, antifungal and antiviral) include mechanism of

action, spectrum against different microorganisms and how the microorganisms create resistance

mechanisms to combat against the used drugs. Also the course covers different methods used for

sterilization and evaluation of disinfectants.




A1 a1. Identify the basic principles of pharmaceutical microbiology.

A4 a2. Enumerate the theories and principles of antimicrobial agents and

standardization methods.

A10

a3. Distinguish appropriate Quality Control (QC) criteria to aseptic and sterile

production facilities and other pharmaceutical industry.

a4.

Describe the principles of contamination sources, control of microbial

contamination, sanitation, disinfection, sterilization methods and

microbiological QC of pharmaceutical products.

A13 a5. Classify the antimicrobials including mechanism of action, therapeutic uses,

dosage, contraindications, adverse drug reactions and drug interactions.



B2

b1. Recommend safe laboratory practice in evaluation of antimicrobial activity.

b2. Develop appropriate methods for infection control and promote sterility test

for pharmaceutical products.

b3. Categorize different antimicrobials according to site of action.

B8 b4. Formulate scheme for sterilization methods.

b5. Evaluate the sterility of different pharmaceutical products.

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C2 c1. Handle microorganisms and antimicrobial preparations safely.

C14

c2. Apply quality control (QC) of raw materials as well as pharmaceutical

preparations to determine MIC of various antimicrobial agents.

c3. Perform different methods for antibiotics sensitivity testing.

c4. Interpret methods used for different antibiotics sensitivity testing.

c5. Apply sterility tests for different pharmaceutical products.




D10 d2. Present information clearly in written, electronic and oral forms.

4. Contents:

4.1. Lectures:

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Laboratory Safety and application of aseptic technique 1

2. Pour plate 1

3. Isolation of pure colonies 1

Study

week Topics

No. of

Credit Hours

1. Introduction & course syllabus 2

2. Chemotherapeutic agents, cell membrane inhibitors 2

3. Chemotherapeutic agents cell wall inhibitors 2

4. Chemotherapeutic agents, DNA replication & protein

synthesis inhibitors + Quiz 1 2

5. Antibiotics act on Metabolic pathway & mechanism of

resistance 2

6. Evaluation of antibiotics 2

7. Anti-viral 2

8. Quiz 2

9. Anti-fungal

10. Sterilization (physical and mechanical methods) 2

11. Sterilization (chemical methods) 2

12. None antibiotics 2

13. Contamination of pharmaceutical products 2

14. Final Exam

Total:

2 credit hours 15.

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4. Viable count 1

5. Sensitivity test 1

6. MIC agar 1

7. MIC interpretation by Graphical method 1

8. Quiz 2

9. MIC broth 1

10. Antibiotic assay 1

11. Sterility test 1

12. Revision 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Videos and animation (Simulation)

5.3. Practical laboratories

5.4. L.M.S

5.5. Homework


6.1.Assessment methods:

1. Written exam To assess knowledge, understanding, intellectual and professional

skills.





and confidence.


6.2.Assessment schedule:



Assessment 3 Assignment/activity (students

presentation) all over the term




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6.3.Weighing of Assessments:

1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (students presentation) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1.

Richard A. Harvey and Cynthia N.C. 3rd Edition, (2013).

Lippincott & Illustrated Reviews of Microbiology. North

America: Lippincott and William Wilkins.

Hugo and Russell’s, 8th, (2013) Pharmaceutical Microbiology,

Edition, NJ: Wiley Blackwell (latest edition).

Textbook

2. Journal of Antimicrobial agents and Chemotherapy Periodical

3. www.asm.org

http://www.microbe.org/microbes/virus_or_bacterium.asp Website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction & course syllabus a1, a2 b1,b3 c1 --

2. Chemotherapeutic agents, cell

membrane inhibitors

a1, a2,

a5 b3 c1,c3,c4 --

3 Chemotherapeutic agents cell wall

inhibitors

a1, a2,

a5 b3 c1,c3,c4 --

4.

Chemotherapeutic agents, DNA

replication & protein synthesis

inhibitors

a1, a2,

a5 b3 c1,c3,c4 d1,d2

5. Antibiotics act on Metabolic pathway

& mechanism of resistance a1,a2, a5 b3 c1,c3,c4 d1,d2

6. Evaluation of antibiotics a1,a2,a3 b1,b2 c2,c3,c4 d1,d2

7. Anti-viral a1,a5 b3 c1 d1,d2

9. Anti-fungal a1,a5 b 3 c1 d1,d2

10. Sterilization (physical and mechanical

methods) a1,a3,a4 b2,b4 c2,c5 d1,d2

http://www.asm.org/

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11. Sterilization (chemical methods) a1,a3,a4 b2,b4 c2,c5 d1,d2

12. None antibiotics a1,a2,a4,

a5 b4 c2 d1,d2

13. Contamination of pharmaceutical

products a2,a3, a4 b2,b5 c1,c5 d1,d2

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Laboratory safety and application of

aseptic technique a3 b1 c 1 --

2. Pour plate a3 b2 c2,c3 --

3. Isolation of pure colonies a1,a4 b 2 c2,c3 --

4. Viable count a3,a4 b3 c1 d1,d2

5. Sensitivity test a2,a5 b3 c2,c3,c4 d1,d2

6. MIC agar a2,a4 b3 c2-c4 d1,d2

7. MIC interpretation by Graphical

method a2,a3 b1 c3,c4 d1,d2

9. MIC broth a2,a5 b3 c2-c4 d1-d3

10. Antibiotic assay a3 b3 c2,c3 d1-d3

11. Sterility test a3 b4,b5 c5 d1-d3

12. Revision

Name Signature

Course Coordinator: Dr. Wafaa Ezz ElArab

Head of Department: Prof. Dr. Magda El-Sherbiney


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Course Title: Immunology

Course Code: MB 312




Prerequisite: General Biology (PB 101)


2. Course Aims:

The course is designed to deliver the knowledge about the principles of the immune system

and its regulation in health and disease, also the molecular basis of immune recognition,

transplantation immunology, immune deficiency and autoimmune diseases, and compare

mechanisms of host response against pathogenic agents.




A1 a1 Identify the basic principles of immunology.

A10 a2 Discuss the differences between innate and adaptive immunity.

A11

a3 Describe the principles of immune cell functions and its beneficial role

a4 Recognize the determinant role of the immune system in immunopathological

conditions.

a5 Define different forms of serological tests



B18

b1 Design appropriate methods for identification of immune system components.

b2 Categorize adaptive immune response into cell mediated and humeral

immunity

B21 b3 Review the host parasite relationship

b4 Interpret serological test for the identification of diseases.

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C1 c1 Utilize the proper immunological terminology, to communicate with other

health care professionals.

C5 c2 Perform good pharmacy practice by proper understanding of etiology and

pathophysiology of immune diseases.

C6 c3 Recognize the interpretation of serologic tests in diagnosis of immunological

status.



D2 d1 Retrieve pharmaceutical information from different sources.

D6 d2 Practice independent learning needed for continuous professional

development.

D10 d3 Present information clearly in written, electronic and oral forms.

4. Contents:

4.1. Lectures:

Week No Topics No. of credit

hours

1. Principles of host defense 2

2. Innate immune system 2

3. Immune cells 2

4. Pathways of complement system activations and

its role in immunological response+ Quiz 1 2

5. Antigen and Antibodies

2

6. Humoral & Cell mediated immune response 2

7. Serological tests 2

8. Quiz 2

9. Hypersensitivity 2

10. Tolerance and autoimmunity 2

11. Immunodeficiency 2

12. Transplantation and graft rejection 2

13. Immune response to infectious agents 2

14. Final Exam

Total:

2 credit hours 15.

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4.2. Practical: Not applicable


5.1 Lectures

5.2 Research assignments (Homework)

5.3 Discussion session (Brain storming)

5.4 L.M.S



1. Written exam to assess knowledge, understanding, intellectual and professional skills.

2. Course work to assess knowledge, understanding, intellectual skills, general &


3. Oral exam to assess knowledge, understanding, intellectual skills, general skills

and confidence.

4. Quizzes to assess knowledge, understanding and intellectual skills.




Assessment 3 Assignment/activity (student presentation) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Student presentations) 5


3. Oral Exam 10

Total 100%


No. Reference Type

1.

Jeneway C.A,Travers Jr.P, Walport M,and Sholmchik M J

Immunobiology, 8th edition, (2011), Garland Science Publishing,

New York, USA.

Peter J. Delves, Seamus J. Martin, Dennis R. Burton, and Ivan M.

Roitt. 13th edition, (2017), Roitt’s Essential Immunology, Wiley-

Blackwell, England.

textbook

2. Journal of Medical Microbiology periodical

3. www.roitt.com

www.immunologyonline.com website

http://www.roitt.com/

http://www.immunologyonline.com/

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8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Principles of host defense a1-a4 b1 c1,c2 --

2. Innate immune system a2-a4 b1 c1,c2 --

3. Immune cells a3 b1,b2 c1,c2 --

4.

Pathways of complement system

activations and its role in

immunological response

a1,a2,a5 b1 c1,c2 d2,d3

5. Antigen and Antibodies a1,a2 b1,b2 c1,c2 d2,d3

6. Humoral & Cell mediated immune

response a1-a4 b2 c1,c2 d1-d3

7. Serological tests a5 b4 c1,c3 d1-d3

9. Hypersensitivity a4,a5 b1,b2 c1,c2 d1-d3

10. Tolerance and autoimmunity a4,a5 b1,b2 c1,c2 d1-d3

11. Immunodeficiency a4,a5 b1,b2 c1,c2 d1-d3

12. Transplantation and graft rejection a4,a5 b1,b2 c1,c2 d1-d3

13. Immune response to infectious agents a4,a5 b1-b3 c1,c2 d1-d3

Name Signature

Course Coordinator: Ass. Prof. Dr. Mohamed Youssef


Approval Date 3/ 2/ 2018

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Course Title: Parasitology

Course Code: MB 403




Prerequisite: None

Credit hours: Lecture: 2 Practical : 1 Total: 3

2. Course Aims:

The course equips students with adequate knowledge about endemic parasites, national

parasitic problems and common parasites worldwide and provides students with skills

concerning biological, epidemiological and ecological aspect of parasites causing diseases to

human. Also the course allows the student to design an approach for identification of different

parasites and diagnose effectively any case of parasitic infestation.




A1 a1. Identify the principles of medical parasitology.

A10 a2. Explain the etiology and clinical features of different parasitic diseases.

A11 a3. Illustrate the laboratory diagnosis of different parasitic diseases.

a4. Recognize the morphology and life cycle of different parasites.



B8

b1. Develop appropriate methods for control of different parasitic diseases.

b2. Develop community awareness against parasitic diseases.

B10 b3. Verify the therapeutic principles for the proper selection and use of drugs in

various parasitic disease conditions.

B21

b4. Design a systemic approach for identification of causative agents and

organisms.

b5. Categorize different parasites into cestoda, nematoda, helminthes, protozoa,

and arthropoda.

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C6

c1. Utilize different measures to monitor and control of parasitic infections.

c2. Apply laboratory tests for diagnosis of various diseases.

c3. Interpret the lab report to diagnose infective stage of the parasites.

c4. Illustrate medically important parasites according to microscopic

examination.



D2 d1. Retrieve and critically evaluate clinical laboratory data from different

sources to improve professional competencies.


D10 d3. Present information clearly in written, electronic and oral forms.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction and classification of parasites. 2

2. Cestoda (Taenia & Hymenolepis nana) 2

3. Cestoda (Ecchinococcus and Dipyllobothrium latum) 2

4. Trematoda (Blood flukes) + Quiz 1 2

5. Trematoda (intestinal flukes) 2

6. Nematoda (Ascaris and hook worms) 2

7. Nematoda (Trichuris trichura and Trichenella spiralis) 2

8. Quiz 2

9. Tissue nematode 2

10. Protozoae (Intestinal and Urogenital protozoa) 2

11. Protozoae (Leishmania and Trypanosoma) 2

12. Protozoae (Toxoplasma and Malaria) 2

13. Medical Entomology 2

14. Final Exam

Total:

2 credit hours 15.

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4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction 1

2. Trematoda 1

3. Cestoda (Taenia & Hymenolepis nana) 1

4. Cestoda (Ecchinococcus and Dipyllobothrium latum) 1

5. Nematode (Ascaris and hook worms) 1

6. Nematode (Trichuris trichura and Trichenella spiralis) 1

7. Tissue nematode 1

8. Quiz

9. Intestinal protozoa 1

10. Blood protozoa 1

11. Toxoplasma and Malaria 1

12. Arthropods 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Videos and animation (Simulation)

5.3. Practical laboratories

5.4. L.M.S

5.5. Homework

5.6. Brain storming








and confidence.


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Assessment 3 Assignment/activity (self-learning) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (self-learning) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1.

Richard A. Harvey and Cynthia N.C. 3rd Edition, (2013). Lippincott

& Illustrated Reviews of Microbiology. North America: Lippincott

and WilliamWilkins. textbook

2. Warren Levinson, 14th edition (2016). Review of medical

microbiology and immunology, New york: Mc Graw Hill medical.

3. Journal of parasitology and research and vector biology periodical

4. https://www.campridge.org website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction and classification of parasites. a1 b1,b5 c2 --

2. Cestoda ( Taenia & Hymenolepis nana) a2-a4 b2-b4 c1-c4 --

3. Cestoda ( Ecchinococcus and

Dipyllobothrium latum) a2-a4 b2-b4 c1-c4 --

4. Trematoda (Blood flukes) a2-a4 b2-b4 c1-c4 d1-d3

https://www.campridge.org/

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5. Trematoda (intestinal flukes) a2-a4 b2-b4 c1-c4 d1-d3

6. Nematoda (Ascaris and hook worms) a2-a4 b2-b4 c1-c4 d1-d3

7. Nematoda (Trichuris trichura and

Trichenella spiralis) a2-a4 b2-b4 c1-c4 d1-d3

9. Tissue nematode a2-a4 b2-b4 c1-c4 d1-d3

10. Protozoae (Intestinal and Urogenital

protozoa) a2-a4 b2-b4 c1-c4 d1-d3

11. Protozoae (Leishmania and Trypanosoma) a2-a4 b2-b4 c1-c4 d1-d3

12. Protozoae (Toxoplasma and Malaria) a2-a4 b2-b4 c1-c4 d1,d2

13. Medical Entomology a2-a4 b2-b4 c1-c4 d1,d2

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction a1-a4 b2,b3 c1-c3 --

2. Trematoda a2-a4 b2,b3 c1-c3 --

3. Cestoda( Taenia & Hymenolepis nana) a2-a4 b2,b3 c1-c3 --

4. Cestoda ( Ecchinococcus and

Dipyllobothrium latum) a2-a4 b2,b3 c1-c3 d1-d3

5. Nematode (Ascaris and hook worms) a2-a4 b2,b3 c1-c3 d1-d3

6. Nematode (Trichuris trichura,

Trichenella spiralis) a2-a4 b2,b3 c1-c3 d1-d3

7. Tissue nematode a2-a4 b2,b3 c1-c3 d1-d3

9. Intestinal protozoa a2-a4 b2,b3 c1-c3 d1-d3

10. Blood protozoa a2-a4 b2,b3 c1-c3 d1-d3

11. Toxoplasma and Malaria a2-a4 b2,b3 c1-c3 d1-d3

12. Arthropods a2-a4 b2,b3 c1-c3 d1-d3

Name Signature

Course Coordinator: Dr. Wafaa Ezz Elarab Ahmed



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Course Title: Pharmaceutical Biotechnology

Course Code: MB 421




Prerequisite: None

Credit hours: Lecture:2 Practical:1 Total:3

2. Course Aims:

The course provides the students with the knowledge and skills concerning the different

concepts of fermentation and industrial microbiology, the different concepts of genetic

engineering and gene therapy, different means of getting rid of wastes and pollutants,

bioremediation and bioconversion of wastes and other cheap under-utilized material to

produce certain useful pharmaceuticals.




A1 a1. Explain the principles of bioremediation.

a2. Recognize the principles of genetic engineering.

A12

a3. Describe the role of genomics and biotechnology in the discovery of new

remedies.

a4. Identify different approaches for gene therapy and therapeutic cloning.

a5. Illustrate different fermentation technology.

A24 a6. Define the good manufacturing practice (GMP) and Quality Control (QC)

criteria in microbiological industry.



B2

b1. Assess manufacturing and laboratory practice guidelines in pharmaceutical

biotechnology.

b2. Formulate a systemic approach for different molecular lab diagnosis.

b3. Evaluate different fermentation techniques.

b4. Interpret results for PCR reports.

B5 b5. Design an approach for synthesis of a recombinant molecules

B7 b6. Determine pharmacy practice requirements in handling of biotechnology

products.

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C8 c1. Manage instruments and equipment for DNA extraction, amplification and

isolation safely and efficiently.

C6 c2. Apply bacterial usage as a bio remedies.

c3 Carry out Lab test for soil bacteria identification

C2

c4. Handle and dispose chemicals safely

c5. Solve commonly encountered problems in pharmaceutical manufacturing

processes.

C14 c6. Apply qualitative fermentation techniques to analyze raw materials.



D3 d1. Work effectively in team.

D4 d2. Communicate effectively in a scientific language.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to biotechnology, fermentation and industrial

microbiology. 2

2. Industrial microorganisms and fermentation media. 2

3. Fermentation techniques, fermenters and bioreactors. 2

4. Fermentation upstream and downstream processes.

+ Quiz 1 2

5. Applications of fermentation process. 2

6. Bioremediation and bioleaching. 2

7. Introduction to microbial genetics: DNA and RNA structure

and function. 2

8. Quiz 2

9. Types of RNA, Genetic code, Protein synthesis and methods

of DNA transfer. 2

10. Cloning, DNA mutation and repair. 2

11. PCR and DNA sequencing methods. 2

12. Genetic engineering 2

13. Gene therapy. 2

14. Final Exam

Total:

2 credit hours 15.

23 | P a g e

4.2. Practical:

Study

week Topics

No. of Credit

Hours

1. Lab Safety 1

2. Isolation of soil bacteria (Streptomyces) 1

3. Physical and Microscopical characters of soil bacteria 1

4. Screening of antimicrobial activity of soil bacteria 1

5. Screening of enzymatic activity of soil bacteria 1

6. Extraction of plasmid DNA 1

7. Extraction of chromosomal DNA 1

8. Quiz 2

9. Gene Amplification (PCR) 1

10. Gel Preparation & DNA Loading 1

11. Running of Gel by electrophoreses and gel documentation 1

12. Revision 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Practical sessions.

5.3. Research assignments (Homework)

5.4. L.M.S





3. Course work To assess knowledge, understanding, intellectual skills, general skills

and confidence.


and confidence.


24 | P a g e




Assessment 3 Assignment/activity (students presentation) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (students presentation) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1.

Bernard, R. Glick.; Cheryl, L. Patten. Molecular Biotechnology:

Principles and Applications of Recombinant DNA, Fifth Edition

(2017).

Crommelin D.J.A, Sindelar. R.D, and Meibohm B. (2013)

Pharmaceutical Biotechnology fundamentals and applications, 4th

edition , NY: Springer

Textbook

2. Journal of pharmaceutical biotechnology, PubMed Periodical

3. www.ms-biotech.wisc.edu/biotech-websites.cfm Website


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to biotechnology,

fermentation and industrial microbiology. a5,a6 b1,b2 c4,c6 --

2. Industrial microorganisms and

fermentation media. a5,a6 b1, b3 c3,c5,c6 --

3. Fermentation techniques, fermenters and

bioreactors. a5,a6 b3 c4,c5,c6 --

4. Fermentation upstream and downstream

processes. a5,a6 b3 c3,c4,c6 d1, d2

5. Applications of fermentation process. a5,a6 b3, b6 c5,c6 d1, d2

25 | P a g e

6. Bioremediation and bioleaching. a1,a3,a6 b3, b6 c2,c6 d1, d2

7. Introduction to microbial genetics: DNA

and RNA structure and function. a2,a3 b1,b5 c1, c4 d1, d2

9. Types of RNA, Genetic code, Protein

synthesis and methods of DNA transfer. a2,a4 b4,b5 c1,c4,c5 d1, d2

10. Cloning, DNA mutation and repair. a2,a4 b2,b5 c1,c4,c5 d1, d2

11. PCR and DNA sequencing methods. a2,a4 b2,b4,b5 c1,c4,c5 d1, d2

12. Genetic engineering a2,a4 b5,b6 c1,c4,c5 d1, d2

13. Gene Therapy a2,a3,a4 b2,b6 c1,c5 d1, d2

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Lab Safety a6 b1,b6 c1,c4 --

2. Isolation of soil bacteria

(Streptomyces) a3,a6 b1,b3 c2,c3 --

3. Physical and Microscopical characters

of soil bacteria a1 b1 c2,c3 --

4. Screening for antimicrobial activity of

soil bacteria a1, a5 b1,b3 c2,c3,c5 d1,d2

5. Screening of enzymatic activity of soil

bacteria a1, a5 b1,b3 c2,c3,c6 d1,d2

6. Extraction of plasmid DNA a2,a3,a4 b2,b5 c1 d1,d2

7. Extraction of chromosomal DNA a2,a3,a4 b2,b5 c1 d1,d2

9. Gene Amplification (PCR)

a2,a3,a4 b2,b5, b6 c1, c5 d1,d2

10. Gel Preparation & DNA Loading

a3,a4,a6 b2,b4,b5 c1,c4 d1,d2

11. Running of Gel by electrophoreses and

gel documentation a3,a4,a6

b2,b4,b5,

b6 c1,c4 d1,d2

12. Revision

Name Signature

Course Coordinator: Dr. Mohammed Youssif Ali

Head of Department: Prof. Dr. Magda El-Sherbiny


26 | P a g e





Course Title: Public and Environmental Health

Course Code: MB 505




Prerequisite: None


2. Course Aims:

This course is designed to provide the students with the fundamentals of public health and

the basic information about epidemiology, etiology, risk factors, risk groups, control and

prevention of diseases. It also provides the students with the skills of promoting,

maintaining health and preventing disease by using different types of vaccines.




A1

a1. Discuss the basic principles of public health.

a2. Identify the most important non-communicable diseases and outline their

prevention and control.

A10 a3. Recognize basic principle of infection control.

a4. Define the source of infection and mode of transition.

A11 a5. Describe different types of vaccines.

a6 Outline pattern of spread of disease.



B8

b1. Formulate a scheme for infection control polices.

b2. Promote public health awareness.

b3. Categorize different disease according to pattern of spread.

b4. Evaluate compulsory vaccination schedule in Egypt and new vaccines should

be introduced.

27 | P a g e



C6 c1.

Select appropriate methods for isolation of patients according to mode of

transmission.

c2. Monitor methods of infection control of nosocomial infection.

C11 c3. Conduct research study including presentation, analysis and interpretation of

the results.



D3 d1 Interact effectively in team working.

D10 d2 Present information clearly in written, electronic and oral forms.

4. Contents:

4.1. Lectures:


5.1. Lectures

5.2. Indirect learning (Self-learning)

5.3. Homework

5.4. Brain storming (open discussion)

5.5 L.M.S

Study

week Topics

No. of

Credit Hours

1. Introduction of public health 2

2. Epidemiologic characteristics of infectious diseases and

outbreak epidemiology 2

3. Basics of nosocomial infections 2

4. Standards for prevention of health care associated infections +

Quiz 1 2

5. Passive Immunization 2

6. Active Immunization 2

7. Contact Diseases 2

8. Quiz 2

9. Airborne diseases 2

10. Staph aureus and Colistridium food poisoning 2

11. Gram negative bacilli food poisoning 2

12. Diseases transmitted primarily from animals to humans and

arthropod borne diseases 2

13. Non-communicable health problems 2

14. Final Exam

Total:

2 credit hours 15.

28 | P a g e



1. Written exam To assess knowledge, understanding, intellectual and professional

skills.




and confidence.





Assessment 3 Assignment/activity (research project) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (research projects) 5


3. Oral Exam 10

Total 100%


No. Reference Type

1. Raymond S. Greenberg et al., 5th Edition, (2015) Medical

Epidemiology, McGraw-Hill. Textbook

2.

Mary Jane Schneider 5th edition (2017), Introduction to Public

Health, Burlington: Jones & Bartlett learning MA.

3. International journal of infection periodical

4. www.apha.org website

http://www.goodreads.com/author/show/518480.Mary_Jane_Schneider

http://www.apha.org/

29 | P a g e


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction of public health a1,a2,a6 b2,b3 c3 --

2.

Epidemiologic characteristics of

infectious diseases and outbreak

epidemiology

a1,a2,a6 b2,b3 c3 --

3. Basics of nosocomial infections a3,a4 b1,b3 c2,c3 --

4.

Standards for prevention of health care

associated infections by vaccines

+ Quiz 1

a5 b2,b4 c3 d1,d2

5. Passive Immunization a1,a2,a6 b2,b3 c3 d1,d2

6. Active Immunization a1,a2,a6 b2,b3 c3 d1,d2

7. Contact Diseases a3,a4 b1,b2 c1,c2 d1,d2

9. Airborne diseases a3,a4 b1,b2 c1,c2 d1,d2

10. Staph. aureus and Colistridium food

poisoning a3,a4 b1,b2 c1,c2 d1,d2

11. Gram negative bacilli food poisoning a3,a4 b1,b2 c1,c2 d1,d2

12.

Diseases transmitted primarily from

animals to humans and arthropod borne

diseases

a3,a4 b1,b2 c1,c2 d1,d2

13. Non-Communicable health problem a2,a6 b2,b3 c3 d1,d2

Name Signature

Course Coordinator: Dr. Reham Magdy Goda



30 | P a g e

Other Courses Not Opened for Registration

at Academic Year (2017-2018)

Final Approval 2016-2017

31 | P a g e


Course title: Industrial Microbiology and Biotechnology

Course code: MB 423


Department: Microbiology and Biotechnology

Academic level: Elective course

Prerequisite: ----

Credit hours: Lecture:2 Practical:-- Total:--

2. Course Aims:

The course is designed to develop the ability to apply the techniques used in the different phases

of industrial microbiology: discovery, production (including fermentation and scale-up),

bioprocessing and cell banking. It includes the principles in the main applications of micro-

organisms to the industrial production of foods, pure chemicals, proteins and other useful

products, including the use of genetically modified organisms.




A10 a1 Identify structure features of various classes of microorganisms.

a2 Outline growth requirements of different microorganisms.

A11

a3 Mention the various metabolic processes found in bacteria and their role in ecological,

biotechnological and pathogenic functions.

a4 Give examples of different types of biocatalysts and methods of their immobilization

and methods for recovery of products.



B2 b1 Determine different assessments techniques for measuring metabolic activity

B7 b2 Design of different biotechnological processes

B17 b3 Investigate different microorganism and their growth characteristics

b4 Compare between structures of bacteria inside and outside cell wall



C6 c1 Show different classes of microorganisms that identify it by different types of staining

c2 Illustrate different fermentation processes

C11 c3 Illustrate the techniques used for detection of metabolic activity and biotechnological

products

32 | P a g e

d. General and Transferable Skills


D3 d1 Work effectively in team and independently

D4 d2 Use modern technology in retrieving information

4. Contents:

4.1. Lectures:

Week

No. Topics

No. of

credit

hours

1. Introduction 2

2. Definition and historical Backgrounds 2

3. Bacterial cell wall structure + quiz 2

4. Bacterial structure-1 2

5. Bacterial structure-2 2

6. The growth, survival and death of bacteria 2

7. Mid-term --

8. Bacterial metabolism 2

9. Definition of biotechnology and fermentation 2

10. Biocatalysts :industrial application and production 2

11. Fermentation (design and condition adjustment and maintenance) 2

12. Fermentation (design and condition adjustment and maintenance) 2

13. Revision 2

14. Final Exam

2 credit

hours4 15.

4.2. Practical/Tutorial: N.A


5.1. Lectures

5.2. Videos and animation

5.3. Group discussion

33 | P a g e



1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence

3. Oral exam to assess knowledge, understanding, intellectual skills, general skills and

confidence

4. Quizzes to assess knowledge, understanding and intellectual skills

5. Case study to assess the skills of problem-solving and data presentation

6.2.Assessment schedule:

Assessment 1 Quiz 3rd week

Assessment 2 Mid-term 7th week

Assessment 3 Written 14th &15th weeks

6.3.Weighing of Assessments:

Mid-Term Exam & course work 25%

Final-Term Exam 75%

Total 100%


No. Reference Type

1. Review of medical microbiology and immunology.MC Graw

Hill LANCE 12th edition Textbook

2. Prescott, Harley and Klein's microbiology, seventh edition,

2008. Textbook

4. https://www.khanacademy.com

https://www.medscape.com Website


Study

week Course contents

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1. Introduction a1 b4 c1 d1

2. Definition and historical

Backgrounds a1 b4 c1 d1, d2

3. Bacterial cell wall structure a1 b3, b4 c1 d1, d2

4. Bacterial structure-1 a1 b3, b4 c1 d1, d2

5. Bacterial structure-2 a1 b3, b4 c1 d1, d2

https://www.khanacademy.com/

https://www.medscape.com/

34 | P a g e

6. The growth, survival and

death of bacteria a1,a2, a3 b1, b4 c1 d1, d2

8. Bacterial metabolism a2, a3 b1, b4 c3,c1 d1, d2

9. Definition of biotechnology

and fermentation a4 b2 c2 d1, d2

10. Biocatalysts :industrial

application and production a4 b2 c2,c3 d1, d2

11. Fermentation (design and

condition) a4 b2 c2,c3 d1, d2

12. Fermentation (adjustment

and maintenance) a4 b2 c2,c3 d1, d2

Name Signature

Course Coordinator: ---



35 | P a g e


Course title: Human Rights

Course code: MB 531


Department: Microbiology & biotechnology

Academic level: Elective course

Prerequisite: -


2. Course Aims:

Students should gain and understand the basic aspects of Humanity and human rights,

overview of theoretical and practical view, deep knowledge about human rights from both

legal and social science.




A26

a1 Define the concepts of humanity and human rights

a2 Discuss the overview of human rights including theoretical and practical view

a3 Identify the knowledge of human rights from both legal and social science

prospective

a4 Describe historical view on human rights till reading the present institutional frame

work of international human rights



B19

b1 Explain the outlines and details of human rights.

b2 Classify human rights into different aspects (Social and legal)

b3 Investigate different challenges to apply human rights all over the world



C20

c1 Manipulates student to develop the process of human rights.

c2 Employ the basic concepts of human rights.

c3 Analyze the different aspects of human rights



D3 d1 Work in a team

D4 d2 Present data clearly in oral and written presentations

36 | P a g e

4. Contents:

4.1.Lectures:

No. Topic

No. of

credit

hours

1. Introduction of humanity 2

2. Human rights in theory 2

3. Human rights in theory + quiz 2

4. Human rights in practical view 2

5. Difference between social and legal human rights 2

6. Responsibilities of pharmacist and physician 2

7. Midterm ----

8. Human right of patients 2

9. Challenges and difficulties that implement human

rights in different countries 2

10. Effect of application of human rights in

civilization countries development 2

11. Effect of application of human rights in

civilization countries development 2

12. Revision 2

13. Revision 2

14. Final exam

2 credit

hours 15.

4.2.Practical/Tutorial: N.A


5.1. Lectures

5.2. Videos and animation

5.3. Reports and assignments


6.1.Assessment methods:

1. Written exam to assess knowledge, understanding, intellectual and professional skills

3. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence

4. Quizzes to assess knowledge, understanding and intellectual skills


Assessment 1 Quiz 3rd week

Assessment 2 Mid-term 7th week

Assessment 5 Written 14th &15thweeks

37 | P a g e


Mid-Term Exam & course work 25%

Final-Term Exam 75%

Total 100%


No. Reference type

1. T Textbook on International Human Rights 6th Edition by Rhona

Smith Textbook

2. www.immunologyonline.com, khan academy for illustration

immunology website


Study

week Course contents

ILOs

knowledge and

understanding intellectual

skills

professional

and practical

skills

general and

transferable

skills

1. Introduction of

humanity a1 b1 c1 d1

2. Human rights in

theory a2 b1 c1 d2

3. Human rights in

theory a2 b1 c1 d2

4. Human rights in

practical view a2 b1 c1 d2

5.

Difference between

social and legal

human rights

a3 b2 c2 d2

6.

Responsibilities of

pharmacist and

physician

a4 b3 c2 d2

8. Human right of

patients a4 b3 c2 d1

9.

Challenges and

difficulties that

implement human

rights in different

countries

a4 b3 c3 d1

http://www.immunologyonline.com/

38 | P a g e

10.

Effect of application

of human rights in

civilization countries

development

a4 b3 c3 d2

11.

Effect of application

of human rights in

civilization countries

development

a4 b3 c3 d2

12-13 Revision

Name Signature

Course Coordinator: -------

Head of Department: Prof. Dr. Magda Elsherbiny


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