Technology Advances
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Transcript of Technology Advances
Technology Advances
Mark Fornalik & Brian Aylward
Technical Prowess & Innovation Technical Prowess & Innovation
Our historical success has been based on the Our historical success has been based on the design and manufacture of precision, multi-layered design and manufacture of precision, multi-layered films consisting of high-performance, engineered films consisting of high-performance, engineered materials with unique physical and chemical materials with unique physical and chemical propertiesproperties
Small Particle Manufacturing
Ag Antimicrobials Ag Antimicrobials TechnologyTechnology
Effectiveness of any Ag AM will Effectiveness of any Ag AM will depend on three factors:depend on three factors:
1. Ag form (solubility, chemistry, size, etc.)1. Ag form (solubility, chemistry, size, etc.)
2. Delivery vehicle (polymer permeability, Ag release 2. Delivery vehicle (polymer permeability, Ag release rate, surface properties, etc.)rate, surface properties, etc.)
3. Microbial environment (water content, pH, ionic 3. Microbial environment (water content, pH, ionic nature/strength, viscosity, flow, etc.)nature/strength, viscosity, flow, etc.)
Knowledge of all three factors is needed Knowledge of all three factors is needed to design effective productsto design effective products
P
Ribosom
PM
Protein
SH
NH2
Gram NegativeBacteria
P
OL
P
CMDNA
RNA
Gram PositiveBacteria
PTA
O
MycobacteriaA M
Yeast
G
OMP.G.C.
TA
AgAg++/Cell Interaction/Cell Interaction
• Most biocides only impact one cellular functionMost biocides only impact one cellular function
• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means
P
Ribosom
PM
Protein
SH
NH2
Gram NegativeBacteria
P
OL
P
CMDNA
RNA
Gram PositiveBacteria
PTA
O
MycobacteriaA M
Yeast
G
OMP.G.C.
TA
AgAg++/Cell Interaction/Cell Interaction
• Most biocides only impact one cellular functionMost biocides only impact one cellular function
• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means
Modification of Plasma MembraneModification of Plasma Membrane
P
Ribosom
PM
Protein
SH
NH2
Gram NegativeBacteria
P
OL
P
CMDNA
RNA
Gram PositiveBacteria
PTA
O
MycobacteriaA M
Yeast
G
OMP.G.C.
TA
AgAg++/Cell Interaction/Cell Interaction
• Most biocides only impact one cellular functionMost biocides only impact one cellular function
• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means
Interferes with DNA and RNA functionalityInterferes with DNA and RNA functionality
P
Ribosom
PM
Protein
SH
NH2
Gram NegativeBacteria
P
OL
P
CMDNA
RNA
Gram PositiveBacteria
PTA
O
MycobacteriaA M
Yeast
G
OMP.G.C.
TA
AgAg++/Cell Interaction/Cell Interaction
• Most biocides only impact one cellular functionMost biocides only impact one cellular function
• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means
Blocking of Thiol groups on proteins and Blocking of Thiol groups on proteins and enzymes enzymes
Biocides, Biostats & BiofilmsBiocides, Biostats & Biofilms
Killing Microbes
Ag+
biostatic
Stopping Biogrowth
planktonicAg+
Ag+
Ag+
biocidalAg
+
Ag+
Ag+
Ag+
Ag+
Ag+
Ag+
Time
Antimicrobial Contamination
(colony forming units)
Surface Concentration of Microbial Species
With Time
Time
Surfaceconcentration
of silver species
Surface Concentration of Silver Species
With Time
Time
Antimicrobial Contamination
(colony forming units)
Surface Concentration of Microbial Species
With Time
Time
Surfaceconcentration
of silver species
Surface Concentration of Silver Species
With Time
SilpureAg-Antimicrobial
Old Generation Ag-Antimicrobial
Silpure FormulationSilpure Formulation• ActiveActive
– Specially formulated silver chemistry for Specially formulated silver chemistry for controlled ion release in microbial controlled ion release in microbial environment (textiles)environment (textiles)
– Manufactured to specific particle size, Manufactured to specific particle size, shape and morphology for optimal shape and morphology for optimal surface coverage and antimicrobial surface coverage and antimicrobial efficacyefficacy
Silpure Formulation…Silpure Formulation…• Binder SystemBinder System
– Polymeric binder system to provide adhesion of silver Polymeric binder system to provide adhesion of silver to fabric materialsto fabric materials
– Co developed with silver technology to provide Co developed with silver technology to provide additional control of ion release for long lasting additional control of ion release for long lasting antimicrobial efficacyantimicrobial efficacy
– Designed for optimal performance in padding processes Designed for optimal performance in padding processes
– Compatible with a wide range of textile auxiliaries Compatible with a wide range of textile auxiliaries
Untreated Fabric- A Untreated Fabric- A Closer LookCloser Look
Treated FabricTreated Fabric Topically adhered Topically adhered
Uniform CoverageUniform Coverage
Maximum DurabilityMaximum Durability
Target application will be 1-3% Target application will be 1-3% (performance dependent)(performance dependent)
Active (silver) concentration in blended Active (silver) concentration in blended product will be 0.24%product will be 0.24%
Final goods will therefore contain Final goods will therefore contain between 0.0024 and 0.0072% active between 0.0024 and 0.0072% active (24-72 ppm)(24-72 ppm)
Product InformationProduct Information
Silpure FBR-5 Performance Evaluation
• Eliminates bacteria growth
• Highly durable antimicrobial performance
1 10 100 1000 10000 100000 1000000 10000000
Log(Bacteria Colony Forming Units)
0
10
20
30
40
50
Wash Cycles
Bacterial Growth on Treated and Untreated Polyester Articles
UntreatedArticle
TreatedArticle