««Technological Technological device device for for industrial solid-phase industrial solid-phase synthessynthesis of peptidesis of peptides»»

“SynChro” Ltd.

«Biomac-Innovation»

General director “SynCho” Ltd.

Dr. Arkavy Igor

127299, Moscow, Klara Zetkin str.4,

Phone/fax: +7-095-459-91-35

“SynChro” Ltd.

Founded in 2004Team is 8 peoples:

3 scientists2 engineers1 technician1 economist1 manager

“SynChro” Ltd.

Founders of “SynChro” Ltd. are: Authors of project from the Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, (Pushchino Moscow region)«Biomac-Innovation»

“SynChro” Ltd. legal form is a small enterprise.

Synthesis of peptides

The automatic solid-phase method for peptides synthesis in automated synthesizers :is the most perspective for manufacturing of peptides;

is used by the leading manufacturers of substances and drugs all around the world;

is complied with GMP requirements.

Advantages of continuous-flow synthesizer

Reduction in price of synthesized product by 30% due to:

decrease in solvent consumption by more than ten times;

decrease in reagent consumption by more than 2-4 times.

Laboratory unit

The pilot batch of laboratory units for automatic solid-phase peptides synthesis was released in 1999, passed all tests and is using in a work till now days.

Key consumersPeptides substances manufacturers for pharmaceutical industry

• Solid-phase synthesis of peptides with following chromatographic purification

Manufacturers of immunobiological drugs

• Purification of drug substances produced using another methods

• Use of accessories (column-reactors, taps, pumps) in different technological processes.

Research and development organizations and universities

• Utilization of analytical synthesizer and accessories

• Rendering of services for solid-phase synthesis and purification of analytical quantities of peptides

Russian analogues

Positioning on the market

Foreign industrial synthesizers of peptideswith batch reactorsPrice: 90.000-350.000 USD

Preparative peptides synthesizer with continuous-flow reactor (model)Estimated price is 30.000 USD

Basic segments of the world marketSegment Quantity of

potential customers

Quantity of peptides

produced (kg)

Annually costs on acquisition of

equipment, (million USD)

Industrial synthesizers 430 300 000 390

Laboratory synthesizers 1 900 150 140

Organic compounds’ synthesizers

12 000 – 210

Scientific equipment 8 000 – 300

Rendering of preparative solid-phase synthesis services

280 140 000 135

Purification of analytical quantity of peptides

200 12 8.5

Total: 22 810 440 162 1 183.5

Basic segments of the market in RussiaSegment Quantity of

potential customers

Quantity of peptides

produced (kg)

Annually costs on acquisition of

equipment, (million USD)

Industrial synthesizers 65 78.00 14,5

Laboratory synthesizers 232 0.120 11,1

Organic compounds’ synthesizers

2 300 – 9,5

Scientific equipment 550 – 10

Rendering of preparative solid-phase synthesis services

187 30.00 0,96

Purification of analytical quantity of peptides

150 0.09 0,54

Total: 3 484 112.33 46,6

The present stage of the projectPresent stage Realization of research and development work (R & D)

Present financing The Foundation for assistance to Small Innovative Enterprises (FASIE) – financing of the first year of research and development work

“Biomac-Innovations” (business-incubation of the project)

Perspective financing

The negotiations are carrying out with a Venture fund about financing the manufacture and creation of technical basis for industrial synthesis and purification peptides custom services.

Structural organization of the project

The realization of the project is carried out by special founded company ”SynChro” Ltd.

Intellectual property The patents for laboratory synthesizer are present.

It is planned to take out patents for useful model and key components of the industrial column-reactor synthesizer till May 2005.

The present stage and future outlook for project financing

Required volume of Required volume of investments for investments for 3 3 yearsyears

$ 2 480 000$ 2 480 000

Required volume of Required volume of investments for investments for 3 3 yearsyears

$ 2 480 000$ 2 480 000

Real financingReal financing Perspective financingPerspective financing

$ 25 000$ 25 000FASIE FundFASIE Fund

(1-(1-st year of R&Dst year of R&D))

$ $ 1125 00025 000FASIE Fund FASIE Fund ((22--ndnd and 3-rd and 3-rd

years of R&Dyears of R&D))

$ $ 300300 000 000Selling of Selling of unexceptionalunexceptional

licenseslicenses

$ $ 1 430 0001 430 000Commercial creditCommercial creditFrom German BankFrom German Bank

$ 360 000$ 360 000Other Russian Other Russian

investmentsinvestments

$ 240 000$ 240 000Subventions from Subventions from Land BrandenburgLand Brandenburg

The structure of expenditures

$ 2 480 000 $ 520 000

LicensingCertificationMarketingPromotion $ 237 000 – 3 year

$ 209 000 – 2 year

$ 74 000 – 1 year

$ 150 000 R&D

$ 75 000 – 3 year

$ 50 000 – 2 year

$ 25 000 – 1 year

$ 1 570 000 Application to production

$ 240 000 Peptides purificationand technical services

$ 237 000 – 2-3 year

Suggested business-planManufacturing and selling of

industrial synthesizersManufacturing and selling of

industrial synthesizers

Manufacturing and selling of laboratory synthesizers

Manufacturing and selling of laboratory synthesizers

Permanent flowing

synthesizer of peptides

Rendering services for industrial peptides synthesis and purifficationRendering services for industrial peptides synthesis and puriffication

Rendering services for synthesis and purification of peptides for laboratoriesRendering services for synthesis and purification of peptides for laboratories

Rendering services for purification of olypeptides obtained by another methods (interferon, insulin, oxytocin, etc.)

Rendering services for purification of olypeptides obtained by another methods (interferon, insulin, oxytocin, etc.)

Manufacturing and selling of accessories, having separate application (columns, pumps, etc.)Manufacturing and selling of accessories, having separate application (columns, pumps, etc.)Technologies transferTechnologies transfer

Next step in project realizationThere are certain problems with There are certain problems with manufacturing and assembling some parts manufacturing and assembling some parts of device in Russiaof device in Russia

SynChro Ltd.SynChro Ltd.

ZABZAB

BrainshellBrainshell

Biomac-Biomac-Innovation Innovation Consulting Consulting TeamTeam Biotechnopark Biotechnopark

in Berlin/Bran-in Berlin/Bran-denburgdenburg

Technological partner in Technological partner in GermanyGermany

Russian marketRussian marketRussian marketRussian market German marketGerman marketGerman marketGerman market

JointJoint manufacturingmanufacturing

““SynChro” Ltd. & SynChro” Ltd. & “Biomac-Innovation” “Biomac-Innovation”

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