Tea and Lowering Cholesterol

7/22/2019 Tea and Lowering Cholesterol

1/3

ScienceDirect - The Journal of Nutritional Biochemistry : Green and black tea extracts inhi...G-CoA reductase and activate AMP kinase to decrease cholesterol synthesis in hepatoma cells

Login:Register

Home Browse My Settings Alerts Help

Quick Search A ll fields Author

Journal/

book title Volume Issue Page

The Journal of Nutritional Biochemistry

Volume 20, Issue 10,October 2009, Pages 816-822 Font Size:

Abstract

Article Figures/Tables

References

Purchase PDF (547 K)

Article Toolbox

E-mail Article Add to my Quick Links

doi:10.1016/j.jnutbio.2008.07.011

Copyright 2009 Elsevier Inc. All rights reserved.

Research article

Green and black tea extracts inhibit HMG-CoA reductase and activate AMP kinase to decrease cholesterol

synthesis in hepatoma cells

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP...on=1&_urlVersion=0&_userid=10&md5=c974f53647395fc53fab685b96c1f7d9 (1 of 3) [10/09/2009 14:49:01]

Dev K. Singha, Subhashis Banerjeeband Todd D. Portera, b, ,

aDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA

bGraduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA

Received 15 May 2008; revised 24 July 2008; accepted 29 July 2008. Available online 15 October 2008.

Abstract

Recent studies have demonstrated that green and black tea consumption can lower serum cholesterol in animals and in man, and suppression of hepatic cholesterol synthesis is

suggested to contribute to this effect. To evaluate this hypothesis, we measured cholesterol synthesis in cultured rat hepatoma cells in the presence of green and black teaextracts and selected components. Green and black tea decreased cholesterol synthesis by up to 55% and 78%, respectively, as measured by a 3-h incorporation of radiolabeled

acetate. Inhibition was much less evident when radiolabeled mevalonate was used, suggesting that the inhibition was mediated largely at or above the level of HMG-CoA

reductase. Both extracts directly inhibited HMG-CoA reductase when added to microsomal preparations, although the extent of inhibition was considerably less than the decrease

in cholesterol synthesis observed in whole cells. As HMG-CoA reductase activity also can be decreased by enzyme phosphorylation by AMP kinase, the phosphorylation state of
https://www.sciencedirect.com/science?_ob=RegistrationURL&_method=display&_type=guest&_returnURL=http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob%3DArticleURL%26_udi%3DB6T8P-4TP1F7J-4%26_user%3D10%26_coverDate%3D10%2F31%2F2009%26_rdoc%3D1%26_fmt%3D%26_orig%3Dsearch%26_sort%3Dd%26_docanchor%3D%26view%3Dc%26_acct%3DC000050221%26_version%3D1%26_urlVersion%3D0%26_userid%3D10%26md5%3Dc974f53647395fc53fab685b96c1f7d9&_acct=C000050221&_version=1&_userid=10&md5=20d6e48a55ace591e60a1eeb51958278http://www.sciencedirect.com/science?_ob=HomePageURL&_method=userHomePage&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6b8f8a0bb11c4ebe676f09e6d7da52c8http://www.sciencedirect.com/science?_ob=BrowseListURL&_type=all&_auth=y&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5c2ba95356d2e928fa0a0f1d2a95c8b2http://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=begin&_btn=Y&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=0a50489567914fe5fc148aaf6fb7fb82http://www.sciencedirect.com/science?_ob=MiamiSDIURL&_method=listAlerts&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ee149f2754ec51cc8403679a69dea736http://www.sciencedirect.com/science?_ob=HelpURL&_file=browse_open_doc.htm&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=285acfba3e995e253df2894ca82cdc1ehttp://www.sciencedirect.com/science/journal/09552863http://www.sciencedirect.com/science/journal/09552863http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235092%232009%23999799989%231488113%23FLA%23&_cdi=5092&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7efdf8f54a16485dc73f44cdaedc5a25http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235092%232009%23999799989%231488113%23FLA%23&_cdi=5092&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7efdf8f54a16485dc73f44cdaedc5a25http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1http://toggletabs%28%27graphtab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=figTables&md5=7280d2d0df7fa3a726f505f575e2b1e0%27)http://toggletabs%28%27reftab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=references&md5=2d9ba68a17dd5a9278aeb7165fe9ed2d%27)http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfhttp://www.sciencedirect.com/science?_ob=EmailFriendURL&_method=gatherInfo&refSource=abst&count=1&_uoikey=B6T8P-4TP1F7J-4&_acct=C000050221&_version=1&_userid=10&md5=ac305ee2ddc8a495015478ceb036ec3bhttp://www.sciencedirect.com/science?_ob=QuickLinksURL&_method=createIntLink&_type=abstract&_key=B6T8P-4TP1F7J-4&_acct=C000050221&_version=1&_userid=10&md5=cd3f9a7827a526d86200fc419aa61de6http://dx.doi.org/10.1016/j.jnutbio.2008.07.011http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfmailto:[email protected]://www.sciencedirect.com/science?_ob=HelpURL&_file=doi.htm&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a143a86ddc585c54adbe80b2046626c3http://dx.doi.org/10.1016/j.jnutbio.2008.07.011http://www.sciencedirect.com/science?_ob=RedirectURL&_method=outwardLink&_partnerName=936&_udi=B6T8P-4TP1F7J-4&_targetURL=https%3A%2F%2Fs100.copyright.com%2FAppDispatchServlet%3FpublisherName%3DELS%26contentID%3DS0955286308001733%26orderBeanReset%3Dtrue&_acct=C000050221&_version=1&_userid=10&md5=8fbc9e26b73a65cfc4c4e5a795253bd7http://www.sciencedirect.com/science?_ob=RedirectURL&_method=outwardLink&_partnerName=795&_udi=B6T8P-4TP1F7J-4&_targetURL=http%3A%2F%2Fwww.2collab.com%2Fbookmark%2Faddsd%3Fpii%3DS0955286308001733%26resize_to_fit%3Dyes&_acct=C000050221&_version=1&_userid=10&md5=b30933e93b1c1252bd2bc497e7a37c85http://www.sciencedirect.com/science?_ob=QuickLinksURL&_method=createIntLink&_type=abstract&_key=B6T8P-4TP1F7J-4&_acct=C000050221&_version=1&_userid=10&md5=cd3f9a7827a526d86200fc419aa61de6http://www.sciencedirect.com/science?_ob=QuickLinksURL&_method=createIntLink&_type=abstract&_key=B6T8P-4TP1F7J-4&_acct=C000050221&_version=1&_userid=10&md5=cd3f9a7827a526d86200fc419aa61de6http://www.sciencedirect.com/science?_ob=EmailFriendURL&_method=gatherInfo&refSource=abst&count=1&_uoikey=B6T8P-4TP1F7J-4&_acct=C000050221&_version=1&_userid=10&md5=ac305ee2ddc8a495015478ceb036ec3bhttp://www.sciencedirect.com/science?_ob=EmailFriendURL&_method=gatherInfo&refSource=abst&count=1&_uoikey=B6T8P-4TP1F7J-4&_acct=C000050221&_version=1&_userid=10&md5=ac305ee2ddc8a495015478ceb036ec3bhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T8P-4TP1F7J-4-C&_cdi=5092&_user=10&_orig=search&_coverDate=10%2F31%2F2009&_sk=999799989&view=c&wchp=dGLbVlb-zSkzk&md5=0f2e05fc5aadb6b950e18fd7ad4d3561&ie=/sdarticle.pdfhttp://toggletabs%28%27reftab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=references&md5=2d9ba68a17dd5a9278aeb7165fe9ed2d%27)http://toggletabs%28%27reftab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=references&md5=2d9ba68a17dd5a9278aeb7165fe9ed2d%27)http://toggletabs%28%27reftab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=references&md5=2d9ba68a17dd5a9278aeb7165fe9ed2d%27)http://toggletabs%28%27graphtab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=figTables&md5=7280d2d0df7fa3a726f505f575e2b1e0%27)http://toggletabs%28%27graphtab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=figTables&md5=7280d2d0df7fa3a726f505f575e2b1e0%27)http://toggletabs%28%27graphtab%27%2C%20%27http//www.sciencedirect.com/science/article/ke/B6T8P-4TP1F7J-4?&_coverDate=10%2F31%2F2009&_ap=&_tap=&_sub=N&_fmt=figTables&md5=7280d2d0df7fa3a726f505f575e2b1e0%27)http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235092%232009%23999799989%231488113%23FLA%23&_cdi=5092&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7efdf8f54a16485dc73f44cdaedc5a25http://www.sciencedirect.com/science/journal/09552863http://ad.doubleclick.net/click;h=v8/38a4/0/0/%2a/d;216398968;0-0;9;12966947;3454-728/90;32559214/32577090/1;;~sscs=%3fhttp://www.pmrjournal.orghttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c974f53647395fc53fab685b96c1f7d9&clearQS=yhttp://www.sciencedirect.com/science?_ob=HelpURL&_file=qs_tips.htm&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f6c371af00211a946caf438b85111035http://www.sciencedirect.com/science?_ob=HelpURL&_file=browse_open_doc.htm&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=285acfba3e995e253df2894ca82cdc1ehttp://www.sciencedirect.com/science?_ob=MiamiSDIURL&_method=listAlerts&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ee149f2754ec51cc8403679a69dea736http://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=begin&_btn=Y&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=0a50489567914fe5fc148aaf6fb7fb82http://www.sciencedirect.com/science?_ob=BrowseListURL&_type=all&_auth=y&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5c2ba95356d2e928fa0a0f1d2a95c8b2http://www.sciencedirect.com/science?_ob=HomePageURL&_method=userHomePage&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6b8f8a0bb11c4ebe676f09e6d7da52c8https://www.sciencedirect.com/science?_ob=RegistrationURL&_method=display&_type=guest&_returnURL=http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob%3DArticleURL%26_udi%3DB6T8P-4TP1F7J-4%26_user%3D10%26_coverDate%3D10%2F31%2F2009%26_rdoc%3D1%26_fmt%3D%26_orig%3Dsearch%26_sort%3Dd%26_docanchor%3D%26view%3Dc%26_acct%3DC000050221%26_version%3D1%26_urlVersion%3D0%26_userid%3D10%26md5%3Dc974f53647395fc53fab685b96c1f7d9&_acct=C000050221&_version=1&_userid=10&md5=20d6e48a55ace591e60a1eeb51958278http://www.info.sciencedirect.com/licensing/access/guest_user/http://www.sciencedirect.com/science?_ob=HomePageURL&_method=userHomePage&_lg=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6b8f8a0bb11c4ebe676f09e6d7da52c8


2/3


Related Articles in ScienceDirect

HMG-CoA reductase and AMP kinase, which is activated by phosphorylation, was determined in lysates from cells treated with tea extracts. Both extracts increased AMP-kinase

phosphorylation and HMG-CoA reductase phosphorylation by 2.5- to 4-fold, but with different time courses: maximal phosphorylation with green tea was evident within 30 min of

treatment, whereas with black tea phosphorylation was slower to develop, with maximal phosphorylation occurring 3 hours after treatment. These results suggest that both green

and black tea decrease cholesterol synthesis in whole cells by directly inhibiting HMG-CoA reductase and by promoting its inactivation by AMP kinase.

Keywords: Cholesterol; AMP kinase; HMG-CoA reductase; Hepatoma cells; Tea

Article Outline

1. Introduction

2. Methods and materials

2.1. Materials

2.2. Cytotoxicity assays

2.3. Determination of cholesterol synthesis

2.4. Determination of 14C-acetate uptake

2.5. Determination of squalene and lanosterol synthesis

2.6. Determination of HMG-CoA reductase activity in microsomes

2.7. Immunoquantitation of AMP kinase and HMG-CoA reductase

3. Results

4. Discussion

References

Supported in part by grant AT-003488 from the National Institutes of Health.

Corresponding author. Tel.: +1 859 257 1137.

Sponsored Links

AKT Signal TransductionMonitor AKT Activation in Cells

Cell-based GFP /Luc Reporterswww.SABiosciences.com

Angiogenesis Model

High Content Screening Assay

Stimulation and Inhibition Studieswww.tcscellworks.co.uk

OPC Dr. Michazik

high antioxidant activityoligomeric procyanidines

www.biotikon.eu

The Journal of Nutritional Biochemistry

Volume 20, Issue 10,October 2009, Pages 816-822


Tea flavonoids: their functions, utilisation and analys...

Trends in Food Science & Technology

Anti-obesity effects of epigallocatechin-3-gallate, ora...

Journal of Functional Foods

Tea phenols: Antioxidant effectiveness of teas, tea com...Nutrition Research

The effect of ascorbic acid on total antioxidant activi...

Food Chemistry

Novel EPR characterization of the antioxidant activity ...

Spectrochimica Acta Part A: Molecular and Biomolecular ...

View More Related Articles
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx1http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx2http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx3http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx4http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx5http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx6http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx6http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx6http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx7http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx8http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx9http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx10http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx10http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx11http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#bibl001http://googleads.g.doubleclick.net/aclk?sa=l&ai=BOqRbSwOpSry7IITUjQfNmKWkD7GzgQeJxsPUCsCNtwGg8bUBEAEYASCO68IGKAM4AFCJk72OBmC73rqD0AqgAb335_4DsgEVd3d3LnNjaWVuY2VkaXJlY3QuY29tyAEB2gFfaHR0cDovL3d3dy5zY2llbmNlZGlyZWN0LmNvbS9zY2llbmNlL2FydGljbGUvQjZUOFAtNFRQMUY3Si00LzIvZmM2MmU1OTRlMzA4NzI4MjVlNGE0NWI2NmJmYWUxMmSpAq9t8hh82qw-qAMB6AO4A-gDrgHoAy31AwAAAAT1AwQAAAA&num=1&sig=AGiWqtzMrdMbbc2Veg9c-849NYoB_BqL0Q&client=ca-sciencedirect_b_js&adurl=http://www.sabiosciences.com/reportersystem.php%3Fadwordhttp://googleads.g.doubleclick.net/aclk?sa=l&ai=BiSO_SwOpSry7IITUjQfNmKWkD9TJp6kBgqjJsg3AjbcB0KVMEAIYAiCO68IGKAM4AFDEroBCYLveuoPQCrIBFXd3dy5zY2llbmNlZGlyZWN0LmNvbcgBAdoBX2h0dHA6Ly93d3cuc2NpZW5jZWRpcmVjdC5jb20vc2NpZW5jZS9hcnRpY2xlL0I2VDhQLTRUUDFGN0otNC8yL2ZjNjJlNTk0ZTMwODcyODI1ZTRhNDViNjZiZmFlMTJkqQJfT36GTL27PqgDAegDuAPoA64B6AMt9QMAAAAE9QMEAAAA&num=2&sig=AGiWqtz8q_uyL-0v3zDc6lH3KZKn1wFFIw&client=ca-sciencedirect_b_js&adurl=http://tcscellworks.co.uk/angiogenesis/http://googleads.g.doubleclick.net/aclk?sa=l&ai=BQ_-wSwOpSry7IITUjQfNmKWkD_65y4MB7JOk5gvAjbcBgJ9JEAMYAyCO68IGKAM4AFD4ubWp-_____8BYLveuoPQCqABzsPC_QOyARV3d3cuc2NpZW5jZWRpcmVjdC5jb23IAQHaAV9odHRwOi8vd3d3LnNjaWVuY2VkaXJlY3QuY29tL3NjaWVuY2UvYXJ0aWNsZS9CNlQ4UC00VFAxRjdKLTQvMi9mYzYyZTU5NGUzMDg3MjgyNWU0YTQ1YjY2YmZhZTEyZIACAakC2QcW1VRuuD6oAwHoA7gD6AOuAegDLfUDAAAABPUDBAAAAA&num=3&sig=AGiWqtyPuZlWeJjKxc4ztrlSq28_7gtzVQ&client=ca-sciencedirect_b_js&adurl=http://www.biotikon.eu/product_info.php/info/p29_OPC-160-nach-Dr-med-Michalzik.html/XTCsid/834ceb930e39b7411a9298978ba7439ahttp://www.sciencedirect.com/science/journal/09552863http://www.sciencedirect.com/science/journal/09552863http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235092%232009%23999799989%231488113%23FLA%23&_cdi=5092&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7efdf8f54a16485dc73f44cdaedc5a25http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235092%232009%23999799989%231488113%23FLA%23&_cdi=5092&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7efdf8f54a16485dc73f44cdaedc5a25http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VHY-41Y85ND-5&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F05%2F2000&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d327805994c092b85f10ddff959ddc24http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VHY-41Y85ND-5&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F05%2F2000&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d327805994c092b85f10ddff959ddc24http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VHY-41Y85ND-5&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F05%2F2000&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d327805994c092b85f10ddff959ddc24http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B9848-4WTYY6N-2&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=07%2F31%2F2009&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2a794c58c83a86fd7d766e492dab5212http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B9848-4WTYY6N-2&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=07%2F31%2F2009&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2a794c58c83a86fd7d766e492dab5212http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TB1-3TCWVYD-G&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=06%2F30%2F1998&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ea4ab6881745aa44e5ad7bc9731632a2http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TB1-3TCWVYD-G&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=06%2F30%2F1998&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ea4ab6881745aa44e5ad7bc9731632a2http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6R-4BYNPMF-C&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=12%2F31%2F2004&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d09ef32f99591a4f5739efc84a9cf30dhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6R-4BYNPMF-C&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=12%2F31%2F2004&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d09ef32f99591a4f5739efc84a9cf30dhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VNG-44VX72Y-B&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F30%2F2002&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9dabac30ae81f7a487991de9dfc817eahttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VNG-44VX72Y-B&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F30%2F2002&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9dabac30ae81f7a487991de9dfc817eahttp://www.sciencedirect.com/science?_ob=RelatedArtURL&_udi=B6T8P-4TP1F7J-4&_orig=article&_acct=C000050221&_version=1&_userid=10&md5=c125efaa03f4c0abc21955a5882f591dhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VNG-44VX72Y-B&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F30%2F2002&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9dabac30ae81f7a487991de9dfc817eahttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VNG-44VX72Y-B&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F30%2F2002&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9dabac30ae81f7a487991de9dfc817eahttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6R-4BYNPMF-C&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=12%2F31%2F2004&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d09ef32f99591a4f5739efc84a9cf30dhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6R-4BYNPMF-C&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=12%2F31%2F2004&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d09ef32f99591a4f5739efc84a9cf30dhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TB1-3TCWVYD-G&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=06%2F30%2F1998&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ea4ab6881745aa44e5ad7bc9731632a2http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TB1-3TCWVYD-G&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=06%2F30%2F1998&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ea4ab6881745aa44e5ad7bc9731632a2http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B9848-4WTYY6N-2&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=07%2F31%2F2009&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2a794c58c83a86fd7d766e492dab5212http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B9848-4WTYY6N-2&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=07%2F31%2F2009&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2a794c58c83a86fd7d766e492dab5212http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VHY-41Y85ND-5&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F05%2F2000&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d327805994c092b85f10ddff959ddc24http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VHY-41Y85ND-5&_user=10&_origUdi=B6T8P-4TP1F7J-4&_fmt=high&_coverDate=04%2F05%2F2000&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d327805994c092b85f10ddff959ddc24http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235092%232009%23999799989%231488113%23FLA%23&_cdi=5092&_pubType=J&view=c&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7efdf8f54a16485dc73f44cdaedc5a25http://www.sciencedirect.com/science/journal/09552863http://googleads.g.doubleclick.net/aclk?sa=l&ai=BQ_-wSwOpSry7IITUjQfNmKWkD_65y4MB7JOk5gvAjbcBgJ9JEAMYAyCO68IGKAM4AFD4ubWp-_____8BYLveuoPQCqABzsPC_QOyARV3d3cuc2NpZW5jZWRpcmVjdC5jb23IAQHaAV9odHRwOi8vd3d3LnNjaWVuY2VkaXJlY3QuY29tL3NjaWVuY2UvYXJ0aWNsZS9CNlQ4UC00VFAxRjdKLTQvMi9mYzYyZTU5NGUzMDg3MjgyNWU0YTQ1YjY2YmZhZTEyZIACAakC2QcW1VRuuD6oAwHoA7gD6AOuAegDLfUDAAAABPUDBAAAAA&num=3&sig=AGiWqtyPuZlWeJjKxc4ztrlSq28_7gtzVQ&client=ca-sciencedirect_b_js&adurl=http://www.biotikon.eu/product_info.php/info/p29_OPC-160-nach-Dr-med-Michalzik.html/XTCsid/834ceb930e39b7411a9298978ba7439ahttp://googleads.g.doubleclick.net/aclk?sa=l&ai=BiSO_SwOpSry7IITUjQfNmKWkD9TJp6kBgqjJsg3AjbcB0KVMEAIYAiCO68IGKAM4AFDEroBCYLveuoPQCrIBFXd3dy5zY2llbmNlZGlyZWN0LmNvbcgBAdoBX2h0dHA6Ly93d3cuc2NpZW5jZWRpcmVjdC5jb20vc2NpZW5jZS9hcnRpY2xlL0I2VDhQLTRUUDFGN0otNC8yL2ZjNjJlNTk0ZTMwODcyODI1ZTRhNDViNjZiZmFlMTJkqQJfT36GTL27PqgDAegDuAPoA64B6AMt9QMAAAAE9QMEAAAA&num=2&sig=AGiWqtz8q_uyL-0v3zDc6lH3KZKn1wFFIw&client=ca-sciencedirect_b_js&adurl=http://tcscellworks.co.uk/angiogenesis/http://googleads.g.doubleclick.net/aclk?sa=l&ai=BOqRbSwOpSry7IITUjQfNmKWkD7GzgQeJxsPUCsCNtwGg8bUBEAEYASCO68IGKAM4AFCJk72OBmC73rqD0AqgAb335_4DsgEVd3d3LnNjaWVuY2VkaXJlY3QuY29tyAEB2gFfaHR0cDovL3d3dy5zY2llbmNlZGlyZWN0LmNvbS9zY2llbmNlL2FydGljbGUvQjZUOFAtNFRQMUY3Si00LzIvZmM2MmU1OTRlMzA4NzI4MjVlNGE0NWI2NmJmYWUxMmSpAq9t8hh82qw-qAMB6AO4A-gDrgHoAy31AwAAAAT1AwQAAAA&num=1&sig=AGiWqtzMrdMbbc2Veg9c-849NYoB_BqL0Q&client=ca-sciencedirect_b_js&adurl=http://www.sabiosciences.com/reportersystem.php%3Fadwordhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#bibl001http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx11http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx10http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx9http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx8http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx7http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx6http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx5http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx4http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx3http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx2http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4TP1F7J-4&_user=10&_coverDate=10%2F31%2F2009&_rdoc=1&_fmt=full&_orig=search&_cdi=5092&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ce7412cff351440624616b8d8031bbb1#secx1http://www.sciencedirect.com/science?_ob=RelatedArtURL&_udi=B6T8P-4TP1F7J-4&_orig=article&_acct=C000050221&_version=1&_userid=10&md5=c125efaa03f4c0abc21955a5882f591d


3/3


Home Browse My Settings Alerts Help

About ScienceDirect | Contact Us | Information for Advertisers | Terms & Conditions | Privacy Policy

Copyright 2009 Elsevier B.V.All rights reserved. ScienceDirect is a registered trademark of Elsevier B.

V.

http://www.sciencedirect.com/science?_ob=HomePageURL&_method=userHomePage&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6b8f8a0bb11c4ebe676f09e6d7da52c8http://www.sciencedirect.com/science?_ob=BrowseListURL&_type=all&_auth=y&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5c2ba95356d2e928fa0a0f1d2a95c8b2http://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=begin&_btn=Y&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=0a50489567914fe5fc148aaf6fb7fb82http://www.sciencedirect.com/science?_ob=MiamiSDIURL&_method=listAlerts&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ee149f2754ec51cc8403679a69dea736http://www.sciencedirect.com/science?_ob=HelpURL&_file=browse_open_doc.htm&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=285acfba3e995e253df2894ca82cdc1ehttp://info.sciencedirect.com/http://www.sciencedirect.com/science?_ob=MiamiCommentURL&_method=comment&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=35de5c36da5433e32b1b3357b12a114chttp://www.elsevierscitech.com/forms/sd/form.htmlhttp://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=displayTerms&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=fee479c52e700c6acacefce9e2106a6fhttp://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=displayPolicy&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=9e5aa4a0cc7bfb68a086a1438e8bfb51http://www.elsevier.com/http://www.elsevier.com/http://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=displayPolicy&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=9e5aa4a0cc7bfb68a086a1438e8bfb51http://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=displayTerms&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=fee479c52e700c6acacefce9e2106a6fhttp://www.elsevierscitech.com/forms/sd/form.htmlhttp://www.sciencedirect.com/science?_ob=MiamiCommentURL&_method=comment&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=35de5c36da5433e32b1b3357b12a114chttp://info.sciencedirect.com/http://www.elsevier.com/http://www.sciencedirect.com/science?_ob=HelpURL&_file=browse_open_doc.htm&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=285acfba3e995e253df2894ca82cdc1ehttp://www.sciencedirect.com/science?_ob=MiamiSDIURL&_method=listAlerts&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ee149f2754ec51cc8403679a69dea736http://www.sciencedirect.com/science?_ob=UserSubscriptionURL&_method=begin&_btn=Y&_acct=C000050221&_version=1&_urlVersion=1&_userid=10&md5=0a50489567914fe5fc148aaf6fb7fb82http://www.sciencedirect.com/science?_ob=BrowseListURL&_type=all&_auth=y&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5c2ba95356d2e928fa0a0f1d2a95c8b2http://www.sciencedirect.com/science?_ob=HomePageURL&_method=userHomePage&_btn=Y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6b8f8a0bb11c4ebe676f09e6d7da52c8

Tea and Lowering Cholesterol

Documents

Transcript of Tea and Lowering Cholesterol