TDMS No. P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date …Date Report Reqsted: 06/15/2006 : Test Type:...
Transcript of TDMS No. P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date …Date Report Reqsted: 06/15/2006 : Test Type:...
TDMS No 20201 - 03
Test Type 26-WEEK
Route SKIN APPLICATION
SpeciesStrain MICETGAC HEMI
C Number
Lock Date
Cage Range
Date Range
Reasons For Removal
Removal Date Range
Treatment Groups
P04 NEOPLASMS BY INDIVIDUAL ANIMAL TEF TRANSGENICS (PECDF)
CAS Number 57117-31-4
Date Report Reqsted 06152006
Time Report Reqsted 124412
First Dose MF NA 042103
Lab BAT
C20201C
07242004
ALL
ALL
ALL
ALL
Include ALL
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Mesentery + 1
Salivary Glands + 1
Squamous Cell Carcinoma X 1
Stomach Forestomach + + + + + + 6
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X 1
Stomach Glandular + 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 2
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
NONE
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
Ovary
+ 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + + 20
INTEGUMENTARY SYSTEM
Skin + + + + 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 3
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Squamous Cell Papilloma X 1
Skin Soa No Mass + + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
AlveolarBronchiolar Adenoma
Leukemia Erythrocytic
+ + + + + + + + + + + + + + + + + + + + 20
X 1 X 1
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 4
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 5
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Mesentery + 1
Pancreas + 1
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM NONE
GENERAL BODY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 6
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Mesentery + 1
Salivary Glands + 1
Squamous Cell Carcinoma X 1
Stomach Forestomach + + + + + + 6
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X 1
Stomach Glandular + 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 2
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
NONE
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
Ovary
+ 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + + 20
INTEGUMENTARY SYSTEM
Skin + + + + 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 3
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Squamous Cell Papilloma X 1
Skin Soa No Mass + + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
AlveolarBronchiolar Adenoma
Leukemia Erythrocytic
+ + + + + + + + + + + + + + + + + + + + 20
X 1 X 1
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 4
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 5
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Mesentery + 1
Pancreas + 1
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM NONE
GENERAL BODY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 6
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
NONE
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
Ovary
+ 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + + 20
INTEGUMENTARY SYSTEM
Skin + + + + 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 3
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Squamous Cell Papilloma X 1
Skin Soa No Mass + + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
AlveolarBronchiolar Adenoma
Leukemia Erythrocytic
+ + + + + + + + + + + + + + + + + + + + 20
X 1 X 1
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 4
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 5
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Mesentery + 1
Pancreas + 1
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM NONE
GENERAL BODY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 6
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Squamous Cell Papilloma X 1
Skin Soa No Mass + + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
AlveolarBronchiolar Adenoma
Leukemia Erythrocytic
+ + + + + + + + + + + + + + + + + + + + 20
X 1 X 1
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 4
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 5
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Mesentery + 1
Pancreas + 1
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM NONE
GENERAL BODY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 6
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8
7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 0 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 5
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Mesentery + 1
Pancreas + 1
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM NONE
GENERAL BODY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 6
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Mesentery + 1
Pancreas + 1
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + + + + 6
Odontogenic Tumor X X X X X 5
Odontogenic Tumor Multiple X 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM NONE
GENERAL BODY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 6
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
GENITAL SYSTEM
Ovary + 1
HEMATOPOIETIC SYSTEM
Lymph Node Mandibular + 1
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + + + + + + + + + + + + + + + M + + 19
INTEGUMENTARY SYSTEM
Skin + + + + 4
Squamous Cell Papilloma X X X X 4
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 7
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Keratoacanthoma
Squamous Cell Carcinoma
Squamous Cell Papilloma
Squamous Cell Papilloma Multiple
Skin Soa No Mass
X 1 X 1
X X X X X 5 X X X X X X X X X X 10
+ + + + + + + + + + + + + + + + + + + + 20
MUSCULOSKELETAL SYSTEM NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 8
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8
3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 72 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 9
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Stomach Forestomach + + 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X 1
Tooth + + + 3
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
+ 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 10
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Spleen + + + + + + + + + + + + + + + + + + + + 20
Thymus + + + M + + + + + + + + + + + + + + + + 19
INTEGUMENTARY SYSTEM
Skin + + + + + + + + 8
Squamous Cell Papilloma X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X 2
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16
Skin Soa No Mass + + + + + + + + + + + + + + + + + 17
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 11
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8
3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 242 NGKG
NONE
NERVOUS SYSTEM NONE
RESPIRATORY SYSTEM
Lung
+ + + + + + + + + + + + + + + + + + + + 20
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 12
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Stomach Forestomach + + + + + 5
Squamous Cell Papilloma X X X X X 5
Tooth + 1
CARDIOVASCULAR SYSTEM NONE
ENDOCRINE SYSTEM
Pituitary Gland
Leukemia Erythrocytic
+ 1 X 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 13
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Lymph Node + + + + + + + + 8
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X 1 Lymph Node
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Lumbar Leukemia Erythrocytic X 1
Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin
Renal Leukemia Erythrocytic X 1
Lymph Node Mandibular + + + 3
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + + 2
Spleen + + + + + + + + + + + + + + + + + + + + 20
Leukemia Erythrocytic X 1
Thymus + + + + + + + + + + + + + + + + + + + M 19
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 14
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
0 0 3 4 1
0 0 3 4 2
0 0 3 4 3
0 0 3 4 4
0 0 3 4 5
0 0 3 4 6
0 0 3 4 7
0 0 3 4 8
0 0 3 4 9
0 0 3 5 0
0 0 3 5 1
0 0 3 5 2
0 0 3 5 3
0 0 3 5 4
0 0 3 5 5
0 0 3 5 6
0 0 3 5 7
0 0 3 5 8
0 0 3 5 9
0 0 3 6 0 TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + 7
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X 3
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Keratoacanthoma X 1
Spindle Cell Carcinoma X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X 4
Squamous Cell Papilloma X 1
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19
Skin Soa No Mass + + + + + + + + + + + + + 13
MUSCULOSKELETAL SYSTEM NONE
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 15
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4
0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 720 NGKG
NERVOUS SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Erythrocytic X 1
Squamous Cell Carcinoma Metastatic X 1 Skin
SPECIAL SENSES SYSTEM NONE
URINARY SYSTEM NONE
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 16
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + + + + + + + + + + + 20
Leukemia Granulocytic X 1
Stomach Forestomach + + + + + + + + 8
Squamous Cell Papilloma X X X X 4
Squamous Cell Papilloma Multiple X X X X 4
Tooth + + 2
Odontogenic Tumor X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 17
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + 1
Lymph Node + + + + 4
Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application
Squamous Cell Carcinoma Metastatic X X X 3 Skin
Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin
Lymph Node Mandibular + + + 3
Squamous Cell Carcinoma Metastatic X 1 Skin
Lymph Node Mesenteric + 1
Spleen + + + + + + + + + + + + + + + + + + + + 20
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 18
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Leukemia Granulocytic X 1
Thymus + + + M + + + + + + + + + + + M + + + + 18
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + + + + 13
Squamous Cell Papilloma X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X 5
Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20
Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20
Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20
Spindle Cell Carcinoma X X X 3
Spindle Cell Carcinoma Multiple X 1
Squamous Cell Carcinoma X X X X X 5
Squamous Cell Carcinoma Multiple X X X X X X X 7
Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20
Skin Soa No Mass + + + + + + + + + + + + 12
MUSCULOSKELETAL SYSTEM
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 19
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + 20
AlveolarBronchiolar Adenoma X 1
Leukemia Granulocytic X 1
Squamous Cell Carcinoma Metastatic X X 2 Skin
SPECIAL SENSES SYSTEM
Eye + 1
URINARY SYSTEM
Kidney + 1
Leukemia Granulocytic X 1
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 20
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-
TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006
Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412
Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103
SpeciesStrain MICETGAC HEMI Lab BAT
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5
5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0
TGAC (FVBN) HEMIZYGOUS MICE FEMALE
ANIMAL ID 1520 NGKG
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1
Myelodysplasia X 1
END OF REPORT
Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue
Control data contained within this report was collected on study 20201-01 Page 21
- TDMS No 20201 -03 P0413
- TGAC (FVBN) HEMIZYGOUS MICE FEMALE
- END OF REPORT
-