Amaris Miller Christina Taylor ECED 4300 B Dr. Tonja Root Fall 2008.
Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?
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Transcript of Taylor Miller Marine Anti-Cancer Compounds. What’s the deal?
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Taylor MillerMarine Anti-Cancer Compounds
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Background
• Cancer still claims the lives of many• 1 out of the 6 cancer treatments
hinders tumor growth
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What’s the deal?
• Marine organisms produce anti-cancer compounds
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Current status of marine natural products in anticancer preclinical or clinical trials
Compound (figure number)
Source organism Chemical class Molecular target Current status
Ecteinascidin 743 Ecteinascidia turbinate (tunicate; possible bacterial source)
Tetrahydroisoquinolone alkaloid
Tubulin Phase II
Dolastatin 10 Dolabella auricularia/Symploca sp. (mollusc/cyanobacterium)
Linear peptide Tubulin Phase II
Bryostatin 1 Bugula neritina (bryozoan)
Macrocyclic lactone PKC Phase II
Synthadotin Dolabella auricularia/Symploca sp. (synthetic analogue)
Linear peptide Tubulin Phase II
Kahalalide F Elysia rufescens/Bryopsis sp. (mollusc/green alga)
Cyclic depsipeptide Lysosomes/erbB pathway
Phase II
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Oceanography
• My future career• Help cure or prevent cancer
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Why do you care?
• You may know someone
affected by cancer
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What lies ahead?