Targeted Alpha Therapy - International Atomic Energy Agency · Targeted Alpha Therapy Maria Betti...
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Targeted Alpha Therapy Maria Betti Director European Commission Joint Research Centre Directorate Nuclear Safety and Security
Transcript of Targeted Alpha Therapy - International Atomic Energy Agency · Targeted Alpha Therapy Maria Betti...
Targeted Alpha Therapy
Maria BettiDirector
European Commission Joint Research Centre Directorate Nuclear Safety
and Security
Prostate Cancer Incidence
1.1 million men worldwide
WHO, GLOBOCAN 2012
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Prostate Cancer Mortality
307,000 deaths
6.6% total men deathsWHO, GLOBOCAN 2012
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Targeted Therapy
Selective killing tumor cells
Limited side effects (healthy tissue)
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High energyHigh ionisation density
Clinical Testings
Before treatmentDec. 2014
After 4 treatmentsSept. 2015
Complete response
Life expectation considerably
increased
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Secure supply of 225Ac (IAEA TCP) - Production
Case Study 1 – Argentina
Training
Know-How transfer
Hosting staff at JRC
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Case Study 2 – South AfricaKnowledge Transfer in the Hospitals
Education to use of radio isotopes
Building capacity to treat prostate cancer
Establishing Regional Training Centre in Africa
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225Ac‐PSMA617: Pretoria experience
1 x225Ac‐PSMA
(10 MBq)
Case Study 2 – South Africa
April 2017PSA = 2280 ng/ml
July 2017 PSA = 205 ng/ml
Follow-up Clinical trials
Specific Regulations
Pharmaceutical Industry Involvement
Looking forward to the future2017‐09‐21 9
THANK YOU
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