TALKING TOTHE TITANSColorado’s MedicalDevice Pioneers

DIRECTORYOF COLORADO BIOSCIENCECOMPANIES &RESOURCES

STANDING ON FERTILE GROUNDRoundtables withBioscience Execs

THE URGE TOCONVERGECollaboration Sparks Innovation

FUELINGCOLORADO’SBIOTECH BOOMTechnology Transfer

2005

2005

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BioscienceC O L O R A D O

in this issue

D I R E C T O R Y

28 RESEARCH & EDUCATION INSTITUTIONS

31 BIOTECHNOLOGY/PHARMACEUTICAL COMPANIES

39 MEDICAL DEVICE COMPANIES

48 BIOSCIENCE RESOURCES

4 State Economic Development Director sees aBRIGHT FUTURE FOR COLORADO

6 TALKING TO THE TITANS

10 STANDING ON FERTILE GROUND A roundtable discussionwith Colorado’s emerging and mature bioscience companies

16 THE URGE TO CONVERGECollaboration sparks innovation

21 COLORADO’S BIOSCIENCE RESOURCES

23 FUELING COLORADO’S BIOTECH BOOM

26 COLORADO BIOSCIENCE PARKSThe perfect homes forgrowing companies

Published By: Colorado BioScience Association and Colorado Officeof Economic Development and International Trade

Produced and Edited By: Sage Public Relations Group

Written By: Sage Public Relations Group and Griff/SMC

Design: Tackett Advertising, Ltd.

Advertising Sales: Downs Marketing

Welcome to Bioscience Colorado, theannual collaborative publication of theColorado BioScience Association and theColorado Office of Economic Developmentand International Trade.

Bioscience Colorado provides an in-depthlook at Colorado’s growing life sciencescommunity, from biotech entrepreneurs touniversity research programs and medicaldevice pioneers. We are proud of ouraccomplishments and eager to face thechallenges that lie ahead.

In 2003, An Action Plan to GrowColorado’s Bioscience Clusterrecommended several priorities. Theseincluded nurturing collaborativepartnerships; appointing a state advocatefor bioscience; continued development ofthe Fitzsimons bioscience park; and forminga unified industry association. Althoughwe’ve now accomplished each of thesesteps, we know this is only the beginning.

It is no secret that Colorado is a greatplace to live. It is also a great place to dobusiness. Our Western culture inspires anentrepreneurial spirit that is producingincredible results in new research and

development. Onbehalf of the ColoradoBioScience Association,we invite you to enjoythis glimpse into ourpast, our present, and,most of all, our future.

Denise Brown, Executive DirectorColorado BioScience Association

www.cobioscience.com

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4

He knows that building a world classbioscience cluster takes perseverance,vision and leadership. The key is not tofocus on today’s problems, but to look atwhat is necessary for the state to succeedin the next decade and beyond.

To get there, he’s developed a plan toproduce an environment that nurturesinnovation and fuels growth.

Integration Government and regulatory agencies canoften present multiple layers thatcombined, make things inefficient forbusiness. The key to minimizing thoselayers is collaboration.

The state is implementing mechanismsto spur collaborations among bioscienceentrepreneurs, venture capital, universityfaculty, business associations and serviceproviders to make it easier to access andshare all the resources the state canmuster. It is a creative approach thatVogt believes can provide seriousbenefits to the bioscience community.

Local, state and regional economicdevelopment agencies already worktogether to stimulate international trade.Now Colorado is expanding that modelthrough the Advance Colorado Center,created by Vogt’s office and theUniversity of Colorado at Denver to allowbusiness associations and government

State EconomicDevelopment Director Sees Bright Future for

ColoradoBy Jon Pushkin

“We are on the rightroad. We have a lot

of opportunity in frontof us.”

Looking at the Front Range from his office on the 17th floor of theWorld Trade Center building in downtown Denver, Brian Vogt isconfident that the future is bright for bioscience in Colorado.

The Director of the Colorado Office of Economic Development andInternational Trade, Vogt’s optimism is based on a purpose driven,long-term strategic approach he calls intentional economic development.

Brian Vogt

organizations to share resources in anenvironment that promotes convergenceand collaboration.

Beyond these steps, Vogt is exploringsome “out of the box” ideas to spureconomic development. For example,what if bioscience entrepreneurs couldleap over bureaucratic hurdles andwork together with Colorado’s tourismindustry to attract new early stagefunding and lure new business to the state?

Entrepreneurs, like most people, fall inlove with Colorado the first time theycome here. Why not leverage the state’snatural beauty and lifestyle to create aunique brand using a coordinatedcommunications program to tout theadvantages of doing business here?

CommunicationVogt believes the best way to overcomechallenges is by encouraging teamworkand embracing a long-term vision.The goal is to connect bioscienceentrepreneurs around the state with everyavailable resource to help them succeed— from venture capital to a talentedworkforce, to essential service providers.

A bi-monthly e-newsletter targeted atbiosciences and emerging technologies,and the creation of a bioscience portalon the state Web site to serve as aprimary conduit between entrepreneursand service providers, are twocommunications tactics the state uses tofacilitate networking and enhance thebenefits of doing business in Colorado.

Funding Economic DevelopmentWhile continuing to look at ways toattract out of state venture capital, Vogtdoes not overlook the importance ofgrowing from within. Colorado isworking on several legislative policyinitiatives to help the state competewith other bioscience clusters. The newColorado Venture Capital Authoritydirects $50 million to startup companiesin the next decade. Another bill wouldallow bioscience companies to sell theiroperating losses to profitable businessesthat can apply those losses to their owntax situations.

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B i o s c i e n c e C O L O R A D O

succeed depends on convincing themthat Colorado’s economic future is intheir hands. From Vogt’s vantage point,the future looks very, very bright. �

Vogt’s VisionBy putting all the components into play,Vogt’s vision is a comprehensive, long-term strategy that he is actively selling tobioscience entrepreneurs. Making it

COLORADO BUSINESS FINANCIAL ASSISTANCE OPTIONS

VENTURE CAPITAL: The state of Colorado provides funding for two venture capital funding models — Certified CapitalCompanies and the Venture Capital Authority.

Certified Capital Companies (CAPCOs): The state has six Certified Capital Companies that makeloans and provide equity to Colorado businesses. The CAPCOs are independently operated and generallymake funding decisions. Minimum and maximum investments generally range from $100,000 — $3.3 million.

Venture Capital Authority (VCA): The state provides funding for a new venture capital program toprovide seed and early-stage capital to businesses. The Venture Capital Authority fund manager willmake nearly $50 million in investments in Colorado businesses over the next ten years.

BIOSCIENCE R&D STATE SALES TAX REFUND:Colorado bioscience companies can receive a refund of state sales and use taxes paid on the sale,storage, use or consumption of tangible personal property that is being used in Colorado directly orpredominantly for research and development of biotechnology.

MANUFACTURING EQUIPMENT EXEMPTION:Bioscience companies purchasing manufacturing equipment and machine tools that cost over $500 areexempt from state sales and use tax on these purchases. The following items are also exempt from statesales and use taxes: component parts, fuels and electricity, ink and newsprint, aircraft parts used ingeneral maintenance, interstate long distance telephone charges, farm equipment and machinery andpackaging materials.

ECONOMIC DEVELOPMENT COMMISSION (EDC): Business incentive funds are available for businesses that commit to meet certain job creation or retentionrequirements. Incentives vary based on a number of factors; however, requests generally range between$1,000 and $3,000 per each fulltime job created. The local community must also provide matchingfunds/incentives to the business.

ENTERPRISE ZONE (EZ): A variety of tax benefits are provided for businesses expanding or locating new business facilities ineconomically distressed areas of the state (state designated enterprise zones).

JOB TRAINING GRANT FUNDS: Through the Colorado FIRST Program (targeted to new jobs being created that need training) and theExisting Industry Program (targeted to existing jobs that need retraining for the business to remaincompetitive), the state has funds available to assist with employee training for specific businesses.Generally, up to $800 per employee trained may be provided. Businesses must pay for a minimum of40 percent of the total training costs.

BUSINESS LOANS: The state has 15 Business Loan Funds that operate primarily in the rural areas of the state. The funds arelocally driven, with each loan fund having its own local review committee and board of directors.Generally, the maximum loan size is $250,000; however, this may vary based on the availability of capitaland other factors. Businesses typically commit to meet certain job creation or retention requirements.

INFRASTRUCTURE ASSISTANCE/GRANTS:The state has funds available to assist with constructing public infrastructure needed by a specificbusiness, primarily in rural areas of the state. The state provides the funding to an eligible city orcounty. A business needs to commit to certain job creation or retention requirements. Generally,funding may be provided up to $500,000; however, this amount may vary based on a number offactors.

FEASIBILITY STUDY GRANTS: The state has funds available to assist with feasibility studies in rural areas. Funding goes to an eligiblecity or county; however, the study must be completed in conjunction with a specific business. Thespecific business needs to commit to certain job creation or retention requirements if the project isdetermined to be feasible and is implemented. Generally, funding may be provided up to $20,000 perstudy. This amount may vary based on a number of factors.

For more information visit www.AdvanceColorado.com or call the OEDIT at 303-892-3840.

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Cobe LaboratoriesA 1967 move to Colorado by a smallsouthern California business named CobeLaboratories launched the state’s firstoutstanding success story in medicalequipment manufacturing. That story carrieson today through the global leadership ofGambro, AB.

Bob Collins and Ran Bellows foundedCobe Laboratories in Glendale, Californiato respond to a pressing clinical need.Heart lung machines were a newtechnology, and a Los Angeles hospital needed special tubingto connect their machine to open-heart surgery patients.Collins and Bellows worked with the hospital to develop aheart lung plastic tubing pack.

They soon saw an opportunity in custom tubing that largercompanies overlooked. “Open heart surgery was beginning toexpand,” remembers Collins, “and our timing couldn’t havebeen better.”

Two years later it was time to expand a thriving business. Butland was expensive in Los Angeles. Another problem, saysCollins, was that “product shipments of less than full truckstook 24 to 30 days to reach our East Coast customers.”Collins had lived in Denver. He understood the advantages ofits central location and lifestyle. He began making inquiries.

In response, Forward Metro Denver, apredecessor to the Metro Denver EconomicDevelopment Corporation, sentrepresentatives to visit Collins and Bellows.“They put us in touch with real estate,financing and sourcing professionals,”Collins says.

Collins and Bellows negotiated a lease withpurchase option for a building constructedto their specifications on 11 acres inLakewood. “Colorado’s lower costs gave usthe opportunity to have our own facility in

a community we would enjoy living in,” Bellows says.

At home in Colorado, they redefined themselves. No longerjust tubing set manufacturers, Cobe Laboratories would nowfocus on the evolving new therapies that would require newtechnologies. This became the company’s driving force andorganizing principle for the years of dramatic growth ahead.

But first they had to recruit an organization to achieve thatmission. “Rather than just going for experience, weconcentrated on people who shared our values and wantedto learn and grow,” Collins says. They succeeded, saysBellows, because “talented people at all levels were attracted tothe opportunity to contribute to improved therapies.” Manycame from the University of Colorado.

Four founding fathers of Colorado’s medical device industry talk about

the early days and why Colorado is “absolutely” the right place to be.

Talking To The Titans

COBE LABORATORIES & VALLEYLAB

Top: Cobe Laboratories’Bob Collins & Ran Bellows circa 1970.

Bottom: Valleylab’sRobert Anderson & Fred Ayers

circa 1970.

By Bob Griff and Jere Paulmeno

7

In time, Cobe Laboratories had two laboratory and productionfacilities located in Lakewood and neighboring Arvada. “Thesecommunities were good locations for quality productionworkers,” Bellows says, “and we continued to attract morethrough word of mouth.”

Cobe Laboratories developed an innovative systems approachto product development that blended disposable plastics andelectromechanical equipment. “There are many similarrequirements which apply across therapies,” commentedCollins. Multidisciplinary technical teams moved easily fromone therapy application to another. “Each team worked withmedical specialists to ensure that we were meeting theirneeds,” he says.

The company’s systems approach was first used to developproducts for the extracorporeal therapies used in nephrology.Based on a prototype dialyzer it acquired, Cobe Laboratoriesrefined the technology and later introduced its own Centurysystem used in hemodialysis.

The company also innovated from an acquired technology toproduce the Cobe BCT therapeutic plasma exchange systemused in blood banks. By the late 1980s, the company hadformalized its business emphases into four divisions:nephrology, cardiovascular, blood component technology,and international.

By 1990, annual sales for Cobe Laboratories were $250million. It employed 2,300 people worldwide and wasColorado’s largest medical equipment manufacturer. That year,Gambro, AB, a global medical products company based inSweden, acquired the company.

The acquisition brought together two companies from separateworlds with common interests. By 1998, Gambro wastransformed into a fully-integrated company providing bothequipment and services in the area of cardiovascular, renal andextracorporeal therapies. A significant portion of Gambro’sgrowth was due to its dialysis services business, GambroHealthcare, a 565-clinic business area that Gambro sold latelast year to DaVita. The move allowed Gambro to return to itsroots as a medical technology company focused on productsand treatment systems.

“We’re proud of the growth and innovation Gambro has alwaysdisplayed, and we’re confident we are well positioned to strengthenour leadership in renal and cell-based therapies, products andservices,” said Kevin Smith, President of Gambro, Inc., a holdingcompany for Gambro’s businesses in the U.S.

The Lakewood-based Gambro BCT and Gambro Renal Productscontinue to employ a combined Colorado workforce of 1,500. Theentrepreneurial spirit that first lured Collins and Bellows toColorado lives on in Gambro.

ValleylabIn the late ’60s, Karl Mills, a scientist and Denver based distributorfor pacemaker giant Medtronic, recruited Fred Ayers, a fellowdistributor in Virginia, and Robert Anderson, an electrical engineerfrom Medtronic’s home office in Minneapolis, to develop anddistribute electronic medical devices for Valleylab.

By 1970, under the guidance of Anderson, Ayers and a handful ofothers, the company’s innovative design for a solid-stateelectrosurgical generator was fast becoming the standard of care insurgery. Valleylab was on a meteoritic rise to global leadership.

“There were many challenges in those early days,” said Andersonrecently from his home in the foothills outside of Boulder. “Firstof all, there were no road maps in the medical device field onwhat to do and how to grow, so we had to chart our owncourse. From a technology standpoint, we were pushing theenvelope in terms of semiconductor reliability. What’s more, unliketoday, there was an absence of venture capital resources, so we hadto be creative about financing right from the start.”

Creative thinking would continue to be a hallmark of the company.It spearheaded one of Boulder County’s only revenue bondinitiatives to underwrite the development of the company’s newfacilities in the Longbow Industrial Park located north of town,where Valleylab has continued to reside since 1976.

Cobe's Bob Collins, retired and hip-deepin his favorite fishing hole, in Tasmania.

From left to right,Valleylab’s Fred Ayersand Robert Anderson

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9

“The regulatory environment in themedical device field was in its infancy,”commented Anderson. “In the early ’70s,when we wanted to validate productefficacy in a certain procedure ortechnique, we simply recruited acompetent surgeon who wanted to trysomething new. It’s a much more difficultproposition today to bring a medicalproduct to market. Surgery was stillreimbursed on a cost-plus basis, totallyunlike today’s capitated reimbursementstructure. Our timing was perfect!”

With a simpler regulatory environment,market-driven costs, the company’sleading edge technology and the rightpeople in management, Valleylab was ona fast track to success. “Having the rightpeople is the key to success in any newendeavor,” said Anderson. “The first fewhires will make it or break it. It’s beenmy experience that good people tend tohire others like themselves. Or to put itanother way, if you hire some pigeons atthe beginning, don’t expect any eagles tojoin the flock. In great part, Valleylabwas a wonderful experience and successbecause of the founding managementteam. They brought 100 percent to the

job every day, and they hired peoplewho shared their commitment.”

For 10 years, fellow founder Fred Ayersdirected marketing and sales as vicepresident for the company. “In the earlydays, we had to overcome considerableskepticism that our smaller box couldactually perform at least as well as themuch larger tube-type generator thathad dominated the electrosurgicalmarketplace for over 20 years,” saidAyers. “We succeeded in the challenge,not only because of our technology, butthanks to the best sales organization inthe world. Based on our experience withMedtronic, we knew who the influentialsurgeons were and we focused on meetingtheir needs.

“Boulder was a very good energy basefor the early Valleylab,” continued Ayers.“The University of Colorado and IBMwere already providing a strongeconomic foundation for the community.And we were able to secure criticalsupport services locally, like plasticsinjection and molding capabilities thatwould help to fuel the growth of ourdisposable product business. Boulder

was also home to many talentedproduct designers and softwareengineers who also helped sustain our growth.”

In fact, if he had to do it all over again,“I’d absolutely choose Boulder,” saysAyers. “It met the needs of Valleylab very well.”

The innovations by the early foundingfathers of Colorado’s medical deviceindustry created a lasting legacy. Todayover 160 medical device companiesmake their home in Colorado. Many oftheir executives can trace their successback to Cobe or Valleylab. The traditionof medical device invention, highquality innovation, qualitymanufacturing, and leadership thosecompanies started lives on in Colorado’sthriving medical device community. �

B i o s c i e n c e C O L O R A D O

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Q: Why did your company choose Colorado? What are some of the challenges and advantages facingColorado bioscience companies?

Sean: Colorado is a fertile ground to grow a new business.Even though half of all University of Colorado law students are from out of state, 80 percent of them stay and practice inColorado after graduation. Once people are drawn here they tend to stay.

Mike H: Allos Therapeutics originated in Richmond, Virginia.We came to Denver because our first CEO was a Denver nativeand the company relocated here. We’ve been here ever since.

Greg: Baxa moved to Colorado in 1982 with about 12 employees.The founders really wanted to live in Colorado because of thelifestyle. We now have 285 people in Colorado and over 300employees worldwide. As a medical device company, our profileis higher in Colorado than it might be elsewhere. It’s a greatplace to work, with a highly educated workforce.

Mike G: Myogen’s founder, Mike Bristow, was the chief ofcardiology at the University of Colorado. The rest of themanagement team all had Colorado connections as well. Wewere committed to building biotech in Colorado.

continued, page 12

MATURE COMPANIES

1. Greg Baldwin is CEO and Chairman of Baxa, a medical devicecompany founded in 1975 with a twenty-year history in Colorado.Baxa develops innovative methods of medication delivery, includingthe accurate and safe dosing of oral liquid drugs.

2. Michael J. Gerber, M.D. is the Senior Vice President for clinicaldevelopment and regulatory affairs with Myogen, a publicly tradedbiopharmaceutical company discovering new treatments forcardiovascular disorders. Based in Westminster, Myogen spun out ofresearch developed at the University of Colorado.

3. Mike Hart is President of Allos Therapeutics, a Westminster basedoncology development company founded in 1994. The publiclytraded Allos develops and commercializes drugs for improving cancertreatments, including breast, lung, brain and other cancers.

4. Jim Linfield is Managing Partner of the Colorado office of CooleyGodward, one of the most integrated and comprehensive life scienceslegal practices in the country. The firm represents over 500 lifesciences companies, both public and private, in the U.S. andinternationally.

5. Sean Moriarty is the Vice President of business development andcounsel for QLT USA, Inc., the Fort Collins based subsidiary of QLTInc. QLT is a global biopharmaceutical company specializing indeveloping treatments for cancer, eye diseases and dermatological andurological conditions. QLT USA was created when QLT acquiredAtrix Laboratories, Inc. in late 2004.

Standing on Fertile Ground

1 2

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In April 2005, two panels of expertsparticipated in a free flowing discussion ofthe state of bioscience in Colorado. One groupincluded executives from establishedColorado companies. The other panelincluded bioscience entrepreneurs involvedwith young companies.

By Jon Pushkin

11

YOUNG COMPANIES

1. David Allen is the Assistant Vice President for technology transferfor the University of Colorado System. CU’s technology transfer officeplays a vital role in the growth of young bioscience companies.

2. Terry Knapp, M.D., is the President and CEO of OrthonetxIncorporated. Located in Superior, southeast of Boulder, the companydevelops medical devices for distraction osteogenesis (mechanicallyinduced growth of new bone and adjacent soft tissues) to treat humanbone-related tissue deficiencies and deformities.

3. Harry Ross, M.D., is the Managing Partner of Aweida CapitalManagement, located in Superior. Aweida operates a $100 millionfund, providing seed or early stage financing ranging from $500 thousand to $10 million.

4. Randy Swenson heads Proteome Resources, LLC as its Chairmanand CEO. The company, established in 2004, manufactures andprovides biochemistry tools and services for drug discovery and basic research.

5. Ginny Orndorff is President and CEO of Evolutionary Genomics.The Aurora company has developed a patented gene discoveryplatform that sifts through large amounts of genomic data to identifyonly those genes that have a high likelihood of commercial value fordownstream validation.

Q: How does Colorado compare to other majorbioscience clusters?

Terry: Colorado is particularly well positioned to takeadvantage of convergence. Convergence spells the future ofColorado because the state brings together so manytechnologies here.

Harry: One of the really nice things about Colorado is there issuch a nice mix. You can have two great companies fromdifferent areas working together to spin off innovation in atotally different area. The other thing that makes us unique isthat Colorado is big enough to have everything you need, butsmall enough to know where to look for help.

Randy: Fitzsimons (see page 26) gives us a tremendousamount of infrastructure investment to promoteentrepreneurial growth. For a small startup, finding 2,000square feet of lab space is hard to come by. So we setProteome up at Fitzsimons. It really speaks to the level ofinvestment that’s going on there.

David: Entrepreneurship is a lonely pursuit. But the nice thingin Colorado is you don’t have to feel like you are odd or different.There are a lot of people like you and the entrepreneurialcommunity is very supportive. If you are in Colorado anddoing something entrepreneurial, you’re in the right place.

continued, page 14

ExpertRoundtablesFocus on IndustryGrowth

1 2

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By Dan Christopherson

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MATURE COMPANIES continued

Getting good talent isn’t about the money, it’s about thescience. Am I going to have an opportunity to work onsomething that makes a difference? If we can provide goodopportunities to work on something exciting and bring it tofruition, that’s the first step in attracting the talent to Colorado.

Q. Successful businesses need access to top qualityprofessional and technical support. How would you ratethe quality and availability of these services in Colorado?

Greg: The service side in Denver is outstanding, from IT tolegal to accounting. There’s a tremendous environment to dobusiness. We also have some outstanding medical devicecompanies here who laid the groundwork for Baxa’s success,like Cobe, Valleylabs and Gambro.

Sean: Service providers here have an entrepreneurial, Westernspirit that comes through in many ways. For the vast majorityof our needs we can easily get competitive bids.

Q: Some people feel Colorado needs more senior levelexecutive talent. Do you agree?

Greg: Our head of sales and marketing lives here during theweek and flies home on the weekends. To grow you have to beflexible. By and large we have all the senior level talent weneed here but sometimes you have to improvise.

Mike H: I agree with Greg. The preference is always for peopleto live here, but if it’s a person you want badly enough you tryand accommodate them.

Mike G: The bottom line is the team. It’s always better if theteam is all in one place but the key for Colorado biotechexecutives is to be flexible.

Jim: The further you go through the development cycle theshallower the talent pool. That’s because there are relativelyfew companies in Colorado with experience taking drugs tomarket. As more Colorado companies gain that experiencethere will be a deeper talent pool. It’s a problem that solvesitself over time.

Q: A lot of people worry about the impact of theState’s economy on the growth of Colorado’s biosciencecluster. How would you describe the business andeconomic climate in Colorado today, and how do youfeel about the future?

Sean: People need the products we make regardless of theeconomy. The economy may affect individual employees andtheir personal optimism, but Colorado is a great place to be.There is a lot of political pressure on the pharmaceuticalindustry right now but I remain optimistic about the future.

Mike H: Colorado should not undersell our location in themiddle of the country and the benefits of a premier facility likeDenver International Airport. Having easy access to anywherein the U.S. is a real asset, particularly to smaller companies.

Greg: The economic downturn actually gave us a bigger poolto recruit from. Rising energy prices are a concern but I’mgenerally encouraged about the economy.

Jim: A great unwritten story is the success Coloradocompanies like Myogen, Allos, Pharmion and Replidynehave had inlicensing compounds from big pharma. It has alot to do with our very robust phase III pipeline. We’ve neverhad so many drugs in late stage development.

Q: We don’t have much state funding to promotebioscience. If Colorado could do one thing to promotethe industry, what would it be?

Jim: We need complete unequivocal support for the State’sinstitutions of higher education. We have some of the bestpeople working at our universities and colleges. We won’t beable to continue to attract and retain them unless we providestate support for higher education.

Mike G: Every successful biocluster is characterized bystrong universities with great professors spinning outtheir ideas through tech transfer and funded by venturecapital. We need a seamless tech transfer system souniversities can create ideas and commercialize thoseopportunities. It is just critical.

Q: What do you think Colorado’s bioscience industrywill look like in ten years?

Mike H: I’m very optimistic. Good things are happening andsuccess breeds success. CU can be the discovery engine thatdrives it all.

Greg: My hope is that more companies will establishthemselves as Colorado companies and commit to stayinghere long term.

Sean: We will double the number of companies at all levelsand establish a better tech transfer system to help us reachcritical mass.

Jim: Colorado will see a significant increase in the number ofproducts that come to market from university research. Thiswill have an enormous impact on health care in the areas ofcardiology, cancer care, eye health and arthritis.

Mike G: We have all the pieces in place for a successfulbiotech environment. The future is bright. Success is justaround the corner. �

13

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YOUNG COMPANIES continued

Q: New companies constantly need early stage funding.How would you describe the investment environmentin Colorado?

Harry: For a state the size of Colorado, the investmentenvironment is pretty good here. Nationally, we often rank in thetop five in terms of capital investment. When you consider we arein the same company as California, New York and Massachusetts,that’s really good – especially when you crunch that down to a percapita basis. Everybody always wants more money, butcompared to 45 other states I think we are in great shape.

Ginny: As an early stage company, we never have enoughcapital. Colorado really reflects what’s going on in the wholecountry. The trend is not to invest venture capital in very earlystage companies.

Harry: Try raising money in places like Montana or Utah orthe Dakotas or Kansas. There is never enough money, but it’sbetter here than just about anyplace else.

Randy: Colorado needs more funding for early stagecompanies without a product in the pipeline yet. Thanks tothe Colorado BioScience Association (CBSA), it now looks like we are going to get some state-funded investment moneyspecifically focused on early stage bioscience companies. That will be a big boost.

David: Technology transfer comes down to resources. It’s aDarwinian business world out there. Viable ideas becomeconcepts that become companies. Unfortunately, there is morecapacity for productive use of capital than is available today.

What we are seeing across the country is that there are veryfew cases where private source capital does indeed step upsufficiently. So, if we are going to create a vibrant economy,and bioscience is part of it, then that becomes a role forgovernment.

Terry: Colorado has a couple of heroic venture capital fundsbut none totally dedicated to life sciences investments. It’s achicken and egg question. I guarantee you if we had morefunds here dedicated to life sciences, more life sciencescompanies would emerge.

Harry: There is nothing unique about the lack of early stagemoney here at all. People’s risk tolerance has changed. Theyput money into companies that already have revenue, FDAapproval, or are in discussion for acquisition. Since 2000,there are roughly half as many venture capital groups inexistence as there were before. It leaves a big hole as far aswhat can be funded.

Terry: There is a movement afoot to fill the gap – theorganized angels – not just the “mom and pop’s who write acheck angels”, but the West Coast Angels, the CTEK Angels –

all of these groups who are now banding together with adegree of organization we have never seen before.

Q: Another thing young bioscience companies need isready access to high quality talent and resources. Arewe doing a good job of making these resources availableto new companies in Colorado?

Ginny: We are doing a good job here. When we needed to fillsome temporary positions we got people with 20 years ofexperience in microbiology. There is fantastic talent here, andnot just at the executive level. There are also good patent firmshere. And CBSA is creating ties to national resources.

Terry: Colorado’s strengths in recruiting are obvious. Peoplemove here without a job simply for the quality of life. BoulderCounty has more software engineers per capita than anywhereelse in the nation. We have a smorgasbord of very goodresources to draw from.

Harry: We have no problem recruiting people from Californiato Colorado for many reasons, including the cost of living,traffic, and the economy.

Randy: It’s a buyer’s market. Large corporations want tomaintain facilities here simply because the cost of living isrelatively low and the talent and education level is quitehigh. The cost of doing business is pretty good here.

Q: Where do you see your company or organizationtwo years from now and what is the most importantthing you need to get there?

Randy: Our plan is to be a $400,000 per year company in twoyears as a reagent supplier. We need a little bit of capital and alittle bit of time. We have most of the resources we needexcept a little extra funding.

Ginny: We will be cash flow positive, finally. We just did ourfirst strategic alliance last fall and we plan to do several moreover the next several years. And we plan to have millions ofdollars in revenues.

Terry: Orthonetx just acquired an IT company, 20 percent ofa multidisciplinary engineering and manufacturing company,and is merging with a profitable California public companythat is moving its headquarters to Colorado. In two years wewill be a force to be reckoned with.

Harry: We should be doing exactly what we are doing now.

David: We plan on having 15-17 fulltime employees and

royalties north of $20 million. We plan to be financially self-sufficient because we struck the kind of deals that matured tothe level that allows that to happen. In a couple of categories,we will be in the top ten universities in the number of startupswe do – nine to 12 per year. We want people to think of theUniversity of Colorado just after MIT and Stanford when theythink of technology transfer.

Q: What advice do you have for bioscienceentrepreneurs considering Colorado?

Ginny: If you have solid technology and a market for it, youwill find a way.

Randy: Understand your capital resources and where they aregoing to come from.

Terry: Think of the four P’s: production, product, people andpolicy. Go for world class in each category.

Harry: The biggest problem is not the lack of talent, it is lack of experience. Learn from others’ mistakes; don’t make your own.�

15

B i o s c i e n c e C O L O R A D O

Splicing Fusing

Adapting Interfacing

CombiningThese are connective bywords of thebiosciences.

Add to that lexicon another word thatembodies the direction of bioscience inColorado: convergence.

Increasingly, professionals andorganizations with varied expertise arecoming together to spark new productsfrom a variety of technologicalcombinations. For example, photonics-medical devices, nanotech-photonics, IT-biotech, and alternative energy-biotech.

Proactively bringing together the state’sleaders in these disciplines is one of thecentral strategies of the state’s action planto grow Colorado’s bioscience cluster.

While several academic and industrygroups are committed to creatingcollegial, interdisciplinary relationships,the official responsibility for weaving

together the statewide efforts ofseemingly disparate bioscience playersfalls chiefly to Christine Shapard. She isthe director of the state’s Biosciences &Emerging Technologies Initiative, part ofthe Office of Economic Developmentand International Trade (OEDIT).

“Convergence is happening faster inthe bioscience field, even faster thanwe thought it would,” she says. “Weare focusing on it, taking advantage ofColorado’s unique technology assetsto move ourselves ahead of the pack.”

That focus is embodied on a single floorof the same downtown Denver officebuilding where her office isheadquartered. The brainchild of OEDITDirector Brian Vogt, it is called theAdvance Colorado Center. Inpartnership with the University ofColorado at Denver and Health SciencesCenter, it brings together non-profitassociations and industry supportprograms under one roof.

Shapard says it is indicative of the state’sresolve that the new center became areality only five months after the idea

16

was first conceived. She sees this newoffice suite – opened in 2004 – as animportant catalyst for convergence.

The Colorado BioScience Associationbecame the first official tenant. Sincethen, several other organizations with astake in biosciences have moved in,including CTEK Venture Centers, theColorado Software and InternetAssociation, the Colorado EnvironmentalBusiness Alliance/P3, the Colorado FilmCommission and the Colorado Alliancefor Microenterprise Initiatives. TheColorado Nanotech Initiative is set tomove in by mid-2005, as is the ColoradoManufacturers Association.

By bringing together associationsrepresenting various technologicaldisciplines, the center leverages theirmembership bases, networks of contactsand intellectual capital. The center alsopromotes dialogue between associationleaders, whether it is a casualconversation in the center’s coffee roomor more formal interactions such as trademissions and industry conferences.

Shapard says the relatively compact sizeof the bioscience industry in Colorado

The Urge to ConvergeCollaboration Sparks

Innovation for Colorado Bioscience

Above left: Dr. Mervyn Jacobson,President/CEO, XY Inc.

Above right: Dr. Richard Casey, founder andChief Scientific Officer, RMC Biosciences.

Left: Chris Shapard, Director of Colorado’sBiosciences and Emerging TechnologiesInitiative.By Dan Christopherson

17

helps engender convergence. “Clustersform easily here. People tend to hear abouteach other and forge their own alliances.”

An interesting example of bioscienceconvergence is the linkup of agriculturalanimal biology, genetics, fluidics, opticsand photonics. XY Inc. in Fort Collins

provides sex selection technologies tothe U.S. and international dairy andlivestock industries, among others. Todo so, it employs a flow cytometer tosort “X” and “Y” chromosome-bearingsperm populations to help achievedesired sex-selected outcomes in

artificial insemination with at least a 90percent accuracy rate.

In this case, XY’s genetics expertiseconverged with two other entities, thebovine and equine breeding researchgroup at Colorado State University (CSU)Animal Reproduction and BiotechnologyLaboratory, and Cytomation, a medicaltechnology firm manufacturing flowcytometers that rely heavily on photonics.

Dr. Mervyn Jacobson, XY’s president andCEO, and the CSU Research Foundation,remain two of the major shareholders ofthe privately held XY Inc. Dr. Jacobsonalso was chairman and an early investorin Cytomation, a company that developedhardware and software to speed up theflow cytometry process over the existingstate of the art. His ownership ended in2001 when Cytomation merged withDanish-owned Dako to becomeDakoCytomation.

B i o s c i e n c e C O L O R A D O

“Call Me Madam,” the first filly in the world to have her sex predetermined, chases after her mother. Photo courtesy of XY Inc.

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DakoCytomation’s MoFlo SX flow cytometer (high-speed cellsorter), employed by XY, utilizes photonics technology toexcite fluorescent dye in each sperm, then assemble and focusthe fluorescent pulses on a detector that converts light intoelectrical signals; the signals are subsequently transformed intodigital information and conveyed to a computer that controlsthe sorting process. XY Inc.’s early successes include, in 1998,the world’s first sex-selected foal and, the following year, theworld’s first sex-selected calf, using frozen sexed sperm andartificial insemination.

Reflecting on the convergence phenomenon, DakoCytomationVice President of Flow Cytometry, Ulrik Cordes, notes thatflow cytometry itself is the result of convergence of themotivations and interests of physicists, biochemists andbiologists. He feels the XY example is the perfect illustrationof diverse disciplines coming together serendipitously tocreate a new bioscience solution.

“We developed our flow cytometers chiefly to deal with cancercells,” says Cordes, a biochemist by training. The idea of usingthe equipment as a workhorse to sort X’s and Y’s never enteredinto the equation as the company’s flow cytometers evolved.“The only common denominator between what we designedour products for and what XY does is cells. That’s all.” But suchre-purposing is a distinguishing characteristic of convergence,and he points out that the Jet Propulsion Laboratory hasexpressed an interest in someday using his company’s productsto learn more about life on Mars.

After the cells are sorted, diagnostic data is the bottom linefor DakoCytomation. Thus, IT plays an integral role in thecompany’s products and success, just as it does for many ofthe state’s bioscience companies. In Colorado, the ITcompanies involved in supporting the bioscience field rangefrom sales and support offices of internationally prominentnames such as IBM Life Sciences to startups working hard tomake a name for themselves.

Take, for example, another Fort Collins company, RMCBiosciences. Its name reflects its market niche, providingcomputer aided drug design services for the biopharmaceuticalindustry.

Convergence, in a sense, is RMC’s business. According tothe company’s founder and Chief Scientific Officer, Dr. RichardCasey, “We are at the intersection of IT, bioinformatics andcomputational resources to serve the biopharma industry.”

Colorado biopharms that are not large enough to affordcomputational modeling and bioinformatics capabilities turnto RMC. Although the company has just three employees,RMC’s know-how, computational resources and molecularmodeling capabilities allow smaller companies to tap intoimmense databases. RMC helps small biopharms screen outthousands of drug experiment options that prove to have littlechance of becoming drug candidates, thus obviating the needto proceed to what would otherwise be unnecessary, costly andtime-consuming in vitro and in vivo tests.

XY Inc. CEO Mervyn Jacobson (seated) with Maurice Rosenstein and Juan Moreno, partner-owners of Inguran, XY Inc.'s first commercial licensee in the United States. Photo courtesy of XY Inc.

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B i o s c i e n c e C O L O R A D O

Another “small subject” generating growing interest isnanotechnology, the manipulation of matter at the molecularand atomic level to create new products. (A nanometer isabout one-hundred thousandth the width of a human hair.)Experts expect nanotech to play an increasingly prominentrole in bioscience convergence in Colorado.

The state currently ranks third among all 50 states in nanotechpotential according to a study released earlier this year by LuxResearch. This was attributed to a favorable business climateand the presence of university and federal labs in the Denverand Boulder area.

Dr. Louis Hornyak, one of the founders of the ColoradoNanotech Initiative, says that while nanotechnology is appliedto many fields, Colorado’s bioscience enterprises stand to benefitsignificantly from the state’s budding nanotech community.

“Nanotech will enable the biosciences in many ways. Afterall, bioscience is about Mother Nature, and Mother Natureis the ultimate nanotechnologist. At the atomic andmolecular level, you don’t have functionality. The nano level iswhere combinations of atoms and molecules occur,” he says,enabling functionality.

Hornyak believes Colorado’s medical device industry will soonleverage nanotechnology’s key functional advantages of speed,surface impact and inherent property stability. “Nanotech iswhere things happen extremely quickly, immediately impactinga tremendous amount of surface area,” he says. Materialaddressed on a nanoscale level exhibits significantly different,more stable properties, opening up a world of scientific andmanufacturing possibilities. “This will revolutionize bioscience.”

Some companies are ahead of the nanotech curve.Metafluidics, in Golden, brings together bio and nano in itscell sorting technology, which combines microfluidic flows andoptical traps to create lab chips for microbiological research.

Zettacore, located in Denver, is the state’s premier user ofnanotechnology. Zettacore develops molecular memorytechnology and products for semi-conductors. It uses moleculesto store data on semi-conductor devices. Molecular propertiesremain stable at the nano level, permitting very small scaling.

Another example of nanotech’s impact is ALIO Industries ofWheat Ridge. The company designs and builds precisionequipment for nano precision applications, including biomedicalapplications. The company’s stage devices control motion onmicro and nano scales. Its three-axis and six-axis robots areenabling advances in fiber optics alignment and sub-micronautomation. Such technology opens new opportunities formedical device innovation.

Photo courtesy of DakoCytomation.

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Laser technology figures prominently in convergence. Dr. SilviaMioc heads the Colorado Photonics Industry Association, agroup promoting the role of photonics in convergence. The70-member association hosts events focusing on biopharm,nanotechnology and homeland security, and maintains closecontact with the Colorado BioScience Association and theColorado Nanotech Initiative.

“Photonics is both an industry and a technology,” Mioc says.“It serves many different industries, including the biosciences.Because photonics is non-invasive and portable, it has manybioapplications.” She notes, for example, photonics isfundamental to the field of oximetry, which uses light toanalyze and determine hemoglobin oxygen levels.

Nanotech and photonicsconverge at Spectraneticsin Colorado Springs. Thecompany’s technologyfeatures an excimer lasersystem for minimallyinvasive cardiovascularprocedures. Laser cathetersare used to adapt tocircumstances where thegoal is to ameliorateblood flow.

To promote the applicationof photonics, among othertechnologies, the state setup the non-profit ColoradoAdvanced TechnologyCenter to rent photonics

equipment to bioscience and other technology companies.Currently housed in Longmont, plans are underway to movethe center to the University of Colorado – Denver and HealthSciences Center.

Emblematic of the trend toward convergence, the HealthSciences Center itself is moving to the new Fitzsimons campusin Aurora. “Fitz,” as it is known, is a bioscience park wheremedical academicians, students and researchers can join withhospitals, clinics and nascent biotech, pharma and medicaldevice companies to bring a wide, new spectrum of biosciencediscoveries to light.

In Colorado, convergence is more than just a byword, it is anattitude. Every day, at every level, it is helping the industryevolve in exciting new directions. �

21

With nearly 40 years of

bioscience industry

experience, Colorado

has a robust infrastructure to

support biomedical, pharmaceutical

and medical device companies.

Relocating and startup companies

alike will find a full array of

specialized business resources to

help them navigate a complex,

worldwide health care market.

Perhaps the first consideration is physical space. Colorado offersabundant, affordable land for facility sites. Technology parkssuch as Westmoor, Commerce Center Longmont, the DenverBioscience Campus at Stapleton, and Fitzsimons BiosciencePark — adjacent to the University of Colorado Health SciencesCenter, provide master-planned campuses with plenty of roomto grow in proximity to established metropolitan areas.

Site-seeking companies can also call on Colorado real estatespecialists, such as Staubach, and Westfield DevelopmentCompany/Frederick Ross, that are experienced in therequirements of the bioscience industry.

STARTING OR RELOCATING,COLORADO’S BIOSCIENCERESOURCES ARE LONG,STRONG AND DEEP

Entrepreneurs with an idea and a health care relatedmission can find startup incubators all along Colorado’sFront Range. These provide comprehensive physical andservice environments aimed at nurturing new ventures. Severalto note are the Colorado Springs Technology Incubator,Fitzsimons Bioscience Park, Fort Collins Business TechnologyIncubator, and Rose Biomedical Development Corporation, theBoulder Innovation Center, and various CTEK locations.

Bioscience businesses needing design and construction ofspecialized laboratory and production facilities have numerouslocal experts to call on. Specialized architectural firms includeThe Abo Group, LS Planning, RNL Design, Christopher CarvellArchitects, and Maynard/David Partnership. Clean room andlaboratory design services are available from firms such asbioBubble and ISEC Laboratory Services.

Among bioscience construction engineers, managers andcontractors are Cator, Ruma and Associates, HaseldenConstruction, Lauth Property Group, LS Planning, M.A.Mortenson, Martin/Martin, VECO USA, and InterTechPlanning and Design.

Venture capital is a crucial resource for the state’s maturingbioscience industry. Local venture capital firms that invest inthe life sciences include Aweida Capital Management, BoulderVentures, Morgenthaler Ventures, Sequel Venture Partners,Tango, and Quest Capital Partners.

Developing bioscience businesses will also find specializedassistance from state government and educational institutions.For example, the State of Colorado provides state tax andbusiness financing assistance. Business development, technologytransfer and proof of concept programs are offered by theUniversity of Colorado, Colorado State University, andNational Jewish Medical and Research Center.

By Jere Paulmeno

Photo courtesy of NREL.

22

Once the facilities are in place, successful bioscience companiesrequire support from a wide range of highly-skilled people.Over the years Colorado has attracted and grown anestablished network of businesses and industries thatspecialize in serving the bioscience sector.

Experienced legal counsel is well-represented in Colorado,from venture financing to securities law, intellectual property,food and drug, and medical device law. Firms with substantialinternational practices, such as Hogan & Hartson, haveDenver and Boulder area offices. Other firms with specializedexpertise include Cooley Godward, Dorsey & Whitney, Faegre& Benson, Fairfield and Woods, Holland & Hart, HolmeRoberts & Owens, Merchant & Gould, Patton Boggs, SheridanRoss, Snell & Wilmer, Swanson & Bratschun, and Townsendand Townsend and Crew.

Bioscience companies in Colorado can outsource criticalservices to a multitude of highly specialized service providers.Hardware and software R&D, prototyping, contractmanufacturing, components manufacturing, clean rooms, drugdiscovery, computation, laboratory testing and certification,and environmental health and safety are all locally available.

Colorado bioscience companies have easy access to highlyspecialized regulatory consultants. For assistance on regulatorycompliance and quality assurance, the list to consult includesReglera, CBR International, Cericon, Medical DeviceConsultants, and M.W. Wenzel.

For accounting, financial and IT assistance, companies canturn to Pricewaterhouse Coopers, Ernst & Young, TatumPartners and others. Colorado is also home to bioscience-experienced public relations, investor relations and marketing

communications specialists such as Absolutely Public Relations,Burns Marketing Communications, ISIS Public Relations, SagePublic Relations Group, and Griff/SMC MarketingCommunications.

Looking for good talent? With a youthful population andone of the nation’s most highly educated workforces, onlytwo other states have more scientists and engineers thanColorado.

Augmenting the continual influx of educated young people isColorado’s university and community college system. TheUniversity of Colorado, Colorado State University, and theUniversity of Denver offer a wide variety of important life scienceresearch programs. Community and private technical collegesprovide trained workers in a number of relevant disciplines.

Notable among the state’s research hospitals and institutes arethe University of Colorado Hospital, the Eleanor RooseveltInstitute, National Jewish Medical and Research Center, TheChildren’s Hospital and VA Medical Center. High-profilefederal laboratories include the National Renewable EnergyLaboratory, National Institute of Standards and Technology,National Oceanic and Atmospheric Administration and theVector-Borne Disease Lab, of the Centers for Disease Controland Prevention.

Several specialist firms help bioscience companies mineColorado’s fertile human resources for scientists, engineers,managers and other technical staff. These include KellyScientific, Kforce Scientific, Volt Scientific Services, and On Assignment. Contract technical training and humanresource administration services are provided by BiopharmaTraining Institute, Employer Services Group, KnowledgeForge, and others.

Bioscience thrives whenpartnerships provideservices to fill criticalneeds. Colorado, long anattractive place to dobusiness, is broad anddeep in the uniqueresources bioscience andhealth care companiesneed to succeed in afiercely competitivemarket. �

Photo courtesy of NREL.

Photo courtesy of the University of Colorado at Denver and Health Sciences Center.

Technology transfer helps universities and research centers“transfer” their innovations from the lab to the marketplace. Itallows them to license the technology to secure the investmentdollars and means to commercialize the discovery.

Across the state, in university labs and public researchinstitutions, Colorado’s technology transfer wizards are helpingscientists bring their discoveries to life. It’s a dynamiccombination that is just beginning to take off.

University of Colorado (CU)Tech transfer is a high priority at CU. The university providesthe resources to identify, protect, package, and license theintellectual property resulting from the research process. Fromadvising faculty on IP issues to fostering inventor participationin the tech transfer process, CU educates campus researchersabout tech transfer, solicits and analyzes invention disclosuresfrom faculty, students, and staff, and analyzes commercializationfeasibility of university intellectual property.

David Allen, Associate Vice President for technology transfer atCU, says Colorado must do a better job of creating early stagefinancing. He points out that California is investing billions instem cell research, while Colorado is still recovering economicallyand runs the risk of falling behind.

Allen says that CU’s success in discovering new technologies isproof of what can happen when research becomes an institutionalpriority. Federally funded research at CU increased by 77percent from 1996-2001, the third highest increase amongall U.S. universities.

In the past year, nine bioscience companies spun out of CUresearch. “Biology is the most common undergraduate sciencedegree,” says Allen. “The talent is out there. We just have toprovide them with the resources to succeed.”

Colorado State University (CSU)The Colorado State University Research Foundation (CSURF)manages the intellectual property resulting from CSU research.This includes patenting, licensing and marketing technologies;developing close relationships with business and industry;providing support and guidance to startup companies;managing equity positions in startup businesses; evaluatingtechnologies for commercialization potential and matchingopportunities for technology development with Universityresearch capabilities. CSURF also handles any revenue fromtechnology transfer.

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Fueling Colorado’sBiotech BoomTechnology Transfer TakesInnovation from Lab to Market

With over $500 million in annual

life science research activity,

Colorado’s institutions provide a

substantial pipeline for new

technologies.

By Jon Pushkin

24

Kathleen Henry, President and CEO of CSURF, says althoughColorado receives significant research funding there could stillbe clearer communication and enhanced cooperation amongprivate industry, universities and research institutions.Clarifying the rules that govern the use of university facilitiesby private industry, and providing better defined opportunitieson the participation of public university faculty and studentsin startups would help, she says. She also hopes for more statefunding for higher education to help retain top faculty. Inaddition, “gap” funding is needed to bring the relativelyembryonic state of university technology to a level in whichit can be more easily commercialized.

CSU receives approximately $240 million per year in researchfunding, the third highest total among public universitieswithout a medical school.

National Jewish Medical and Research Center Founded in 1899, National Jewish Medical and ResearchCenter is the nation’s top hospital for treating respiratorydiseases. It is the only facility in the world dedicatedexclusively to the treatment of patients with respiratory,

immune and allergic disorders, and is in the top five percentof all U.S. institutions for medical research funding from theNational Institutes of Health.

The National Jewish tech transfer program facilitates thecommercialization of laboratory research in biotechnology,biological materials and biomedical devices. It identifies andprotects intellectual property and facilitates businesspartnerships for collaborative research and technologylicensing. National Jewish has nearly 100 technologies in itsactive portfolio and owns more than 50 issued U.S. patentsplus additional corresponding foreign patents.

Brad Brockbank, manager of the National Jewish tech transferprogram, sees a large gap between developing an academicinnovation and maturing the technology to the point that itbecomes attractive to startups. To help bridge that gap, theinstitution is stepping up its emphasis on translationalresearch, recruiting physician scientists who have a hand inboth research and clinical activities, and developing atechnology enhancement and commercialization fund tomature their intellectual properties and reduce risks forpotential licensees.

“Getting academic innovations tostartups takes resources and acommitment from the institutions toinvest in their own technologies,” saysBrockbank. “It takes a shift in visionat the highest levels of the institutionregarding its mission in thecommunity.”

National Renewable Energy LaboratoryThe National Renewable EnergyLaboratory (NREL) in Golden, part ofthe U.S. Department of Energy, is thenation’s primary laboratory for renewableenergy research.

NREL receives about $210 millionannually in R&D funding, about half ofwhich is spent at its Colorado lab.Additional grant money is distributed touniversities and private companies inColorado and nationally.

Turning biomass materials intorenewable energy is one of NREL’sprimary projects. Biomass is plant mattersuch as trees, grasses, agricultural cropsor other biological material. It can beused as a solid fuel, or converted intoliquid or gaseous forms for theproduction of electric power, heat,chemicals, or fuels. Biomass offers anexciting opportunity to replace importedoil with renewable, domesticallyproduced transportation fuels.

Tom Williams, director of NREL’stechnology transfer office, sayspartnerships create marketopportunities. “Our mission is built onseeing our technologies commercialized,”says Williams. “We tailor ourcollaborations based on the needs of thecompany and the market demands.”Industry partnerships may includecollaborative development, technologylicenses, and the use of NREL facilities.Recent NREL partnerships include alicensing agreement with DuPont toconvert biomass-derived starches andsugars to ethanol, and efforts to supporta local startup company, CommunityPower Corporation, to develop modularbiomass systems for distributed energy needs.

Williams sees a huge opportunity forgrowth in renewable energy. “All theseeds are here to drive the market,” saysWilliams. “High fossil fuel prices,concern about global climate change,and our growing reliance on foreignoil are creating a new urgency tochange our energy sources. Biomassfuels are an important part of thesolution, and other renewable sourcessuch as wind and solar are already seeingdouble digit market growth rates.” �

COLORADO SPINOUTS

Tech transfer “spins out” innovationsfrom the lab to the marketplace. Recentexamples include:

Taligen spun out of the University ofColorado. It employs novel technologyto manipulate the immune system toinhibit inflammation and to targetinhibitors of inflammation to specificsites of tissue injury.

Keen Ingredients uses technologydeveloped at Colorado State University,including a unique plant protein thathas the nutritional quality of animal protein.

MicroPhage is based on technologyfrom the Colorado School of Mines. Itdevelops high-speed bacteria detectiontechnologies for use in food safety,environment contamination, evaluationof infectious agents in humans andanimals, industrial pathogens, andbiological warfare threat agents.

25

Photo courtesy of Fitzsimons Redevelopment Authority

26

Colorado Bioscience Park Aurora at Fitzsimons Located just east of Denver in Aurora, one of the most advancedbioscience communities in the world is growing on the 578-acresite of the former Fitzsimons Army Medical Center.

Colorado’s $4.3 billion “square mile of life sciences” has becomethe launch pad, hub and focus for the biotechnology industry inthe Rocky Mountain region. The 160-acre Colorado Bioscience

Park Aurora is the first universityaffiliated “biopark” to bedeveloped west of theMississippi. Adjacent to theUniversity of Colorado HealthSciences Center and Hospital,The Children’s Hospital, and theFitzsimons Commons towncenter, it can accommodate early-stage, startup, and establishedbioscience companies looking fora research community alongside

a world class academic medical institution.

The research park’s incubator currently houses 13 early-stagebiotech companies and two university institutes. A new buildingready for occupancy in fall 2005 will accommodate graduates ofthe incubator as well as more advanced companies.

A 600,000 square foot research complex opened in 2005 with1,600 researchers in 240 labs. Through an affiliation betweenthe University of Colorado and Fitzsimons RedevelopmentAuthority, any company in the research park can access the newcore labs in the research complex.

From biotech research and discovery to patient care andeducation, “Fitz” is a Colorado treasure and the largestmedical-related redevelopment project in the nation.

Denver BioScience Center at Stapleton Young urban families are flocking to a new planned communityat the site of Denver’s former airport. Now businesses are, too.The Denver BioScience Center at Stapleton offers strategic andeconomic advantages that can add up to a real opportunity for ayoung business.

The 200-acre bioscience park is 20 minutes from DenverInternational Airport and 10 minutes from downtown Denver.More than three-quarters of Denver’s highly skilled labor forcelives within 30 minutes and parcels can be built-to-suit.

Competitive pricing, tax incentives, a great location,affordable housing, new schools and an experienceddeveloper are just some of the reasons why the DenverBioScience Center at Stapleton is a smart choice.

Longmont - BoulderWith one of the highest educated workforces in the country,the Longmont-Boulder area is home to some of the largestand most successful bioscience companies in the state.Amgen, Array Biopharma, Pharmion and Valleylab are just some examples.

In addition to its talent pool, bioscience companies areattracted to the area by the affordable cost of real estate, theappealing lifestyle, proximity to the University of Coloradoand a business environment poised for growth. CommerceCenter Longmont, recently purchased from Pratt Propertiesby Circle Capital, includes a business park spanning over200 acres and is home to many prominent Coloradobioscience companies. �

Bioscience Parks Provide Perfect Homes for Growing Companies

The University of Colorado at Denver and Health Sciences

Center’s Research Complex 1 at Fitzsimons

By Jon Pushkin

28 Research & Education Institutions

31 Biotechnology/Pharmaceutical

39 Medical Device

48 Bioscience Resources

I N D E X

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Map graphic by Griff/SMC; satellite photo courtesy of Space Imaging

28

Aims Community CollegeGreeleywww.aims.edu

Aims Community College is one of the largest and most comprehensivetwo-year colleges in Colorado. Since 1967 Aims has established fourcampuses, constructed 18 buildings, expanded curriculum to 2,000 day,evening and weekend courses and taught more than 300,000 students.

AMC Cancer Research CenterDenverwww.amc.org

AMC is a national, not for profit research institute dedicated to theprevention and control of cancer and other chronic diseases. AMC isconducting innovative and important research in the areas of cancercausation and prevention, behavioral research, nutrition, clinical andcommunity studies and health communication.

Bonfils Blood CenterDenver Metrowww.bonfils.org

Bonfils Blood Center is one of the nation’s leading community bloodcenters through their commitment to quality service, innovation, researchand technology. They work around the clock to offer a full range of bloodproducts and services to healthcare partners including supplying rare bloodunits or helping to determine the best cross-matched unit to ensure thebest possible patient outcomes.

The Children’s Hospital Research InstituteDenverwww.uchsc.edu/peds/research/ri/

The Children’s Hospital Research Institute (TCHRI) consistently rates as oneof the country’s top ten percent federally funded pediatric researchprograms. TCHRI has achieved many firsts, including performing pediatricliver transplants, identifying causes of toxic shock syndrome and usingnitric oxide for pulmonary hypertension. TCHRI now has a formalized techtransfer process with CU. Current research focuses include developmentalbiology, obesity, outcomes research, experimental therapeutics and clinicaltrials organization. Clinical research at Children’s is a qualified enterprisezone from Adams County Economic Development. Children’s also has onlyone of six pediatric general clinical research centers in the nation.

Colorado School of MinesGoldenwww.mines.edu

Colorado School of Mines (CSM) is a public research university internationallyrecognized for its leadership in engineering, applied science and relateddisciplines, with a special emphasis on the Earth and its resources.

Colorado State UniversityFort Collinswww.colostate.edu

Colorado State University (CSU) expended approximately $225 million insponsored research in fiscal year 2004. CSU is designated by the CarnegieFoundation as being in the highest level of research classification:“Doctoral / Research Universities – Extensive.” CSU boasts strong programsin veterinary medicine, biotechnology, engineering, agriculture, and naturalresources. The CSU Center for Advanced Technology provides a physicallocation for companies and fosters relationships between CSU’s researchprograms and private industry. The Center is home to the Natural ResourcesResearch Center campus where nearly 1,000 federal employees work. TheJames L. Voss Veterinary Teaching Hospital is adjacent to the Center.

Community College of AuroraAurorawww.ccaurora.edu

The Community College of Aurora (CCA) provides lifelong educationalopportunities, prepares the current and future workforce, and promotesexcellence in teaching, learning and service to our diverse community.

Denver Veterans Administration Medical CenterDenver

The Denver Veterans Administration Medical Center (VAMC) is nationallyand internationally recognized for its long and productive record ofconducting high quality basic science and clinical research. Over fortyDenver VAMC physicians and Ph.D. scientists annually conduct more than450 research studies with total research expenditures at over $17 million.

DeVry UniversityDenver, Westminster, Colorado Springswww.devry.com

DeVry University is one of America’s premier institutions of higher learning,providing career-focused undergraduate and graduate degree programs intechnology, business and management. For over 70 years, DeVry hasworked with industry leaders to define emerging requirements, developcurriculum and deliver education that is relevant for both personal andcorporate workforce development. DeVry supports the workforcerequirements of the bioscience industries with specialized degrees inBiomedical Informatics and Biomedical Engineering Technology, as well asprograms in business and management. Many programs can be adapted anddelivered on-site for companies needing specialized corporate training fortheir current employees. Call 303-280-7600 for more information.

Division of Vector-Borne Infectious DiseasesFort Collinswww.cdc.gov/ncidod/dvid/

The Division of Vector-Borne Infectious Diseases (DVBID) is part of theU.S. Centers for Disease Control and Prevention (CDC). CDC is the leadfederal agency for protecting the health and safety of people at home andabroad. DVBID serves as a national and international reference center forvector-borne viral and bacterial diseases, such as West Nile virus, Lymedisease, plague, tularemia, yellow fever and dengue. DVBID coordinatesnational disease monitoring activities, conducts field and laboratory research,responds to epidemic situations, develops strategies for disease preventionand control, provides diagnostic reference and epidemiologic consultation,and conducts technical assistance and professional training activities.

Eleanor Roosevelt Institute at the University of DenverDenverwww.nsm.du.edu/eri/

The Eleanor Roosevelt Institute (ERI) was founded on the belief thatbiomedical and genetic research is the most effective, long-term approachto the eventual conquest of human disease. ERI has been at the center ofgenetic research since 1961. ERI’s research accomplishments continue withthe sequencing of chromosome 21, developing the sensitive environmentalagent toxicity test, determining the lethal levels of x-rays for human cellsand participating in the discovery of genes related to colon cancer, LouGehrig’s disease, leukemia, heart disease and Alzheimer’s disease.

Front Range Community CollegeBoulder, Fort Collins, Westminster, Brightonwww.frontrange.edu

Front Range Community College (FRCC) is an institution of higher education.FRCC admits individuals 16 years of age or older who can benefit fromcollege preparatory and two-year college-level credit instruction in generaleducation and occupational areas which may lead to a Certificate or an Associateof Applied Science, Associate of Arts, Associate of Science, or Associate ofGeneral Studies Degree, or lead to transfer to a four-year institution.

National Institute of Standards and TechnologyBoulderwww.nist.gov

The National Institute of Standards and Technology (NIST) is a non-regulatoryfederal agency that operates eight different science and advanced technologyresearch divisions in Colorado. NIST’s list of research accomplishmentsincludes a NIST senior scientist winning the Nobel Prize in 2001 for creatingthe world’s first ”Bose-Einstein condensate.” In 2003 another NIST scientistwon a MacArthur Fellowship for discovering a new quantum gas and wasnamed by Science as one of the top ten scientific advances of the year.

Research & Education Institutions

29

National Jewish Medical and Research CenterDenverwww.nationaljewish.org

National Jewish Medical and Research Center (NJC), the number onerespiratory hospital in the U.S., is also one of the most influentialindependent biomedical research centers in the world. More than 100faculty members conduct basic, translational, and clinical research inimmunology, respiratory medicine, allergy, cancer, and cell and molecularbiology. NJC ranks among the top ten percent of all institutions for NIHsupport and for the impact of its research papers in the fields of MolecularBiology, Genetics, and Biology and Biochemistry. NJC manages a technologyportfolio of more than 100 inventions.

National Renewable Energy Laboratory - National Bioenergy CenterGoldenwww.nrel.gov/biomass/

The National Bioenergy Center, housed at the National Renewable EnergyLaboratory (NREL), maintains world-famous research facilities to developbiological, chemical, and thermochemical technologies that produceeconomic and environmentally sensitive transportation fuels, chemicals,fibers and plastics from organic materials and other renewable biomassresources. The Center maintains laboratory, mini-pilot plant and pilot plantfacilities that are available to private industry, federal and state agencies,and Department of Energy laboratories to develop profitable “biorefinery”business models based on these new technologies.

United States Geological Survey—Center for Biological InformaticsDenverhttp://biology.usgs.gov/cbi/

The Center for Biological Informatics, at the Denver Federal Center,operates the national Biological Information Infrastructure (NBII). This isthe first comprehensive electronic gateway dedicated exclusively tobiological science data and information from sources throughout the world.

University of Colorado HospitalDenverwww.uch.edu

As the flagship teaching and research hospital in the Rocky MountainRegion, the University of Colorado Hospital advances health knowledgethrough research and patient care. Strong research programs inimmunology, cancer, neurosciences, drug and alcohol addiction and in allareas of biomedical science are evidenced by over 3,000 approved clinicaltrials.

University of ColoradoBoulder, Denver, Aurora, Colorado Springswww.cu.edu

The University of Colorado System’s 52,000 students and 28,000 facultyand staff contribute to every facet of life in Colorado. The state’s economicvitality, educated workforce, entrepreneurial climate, cultural capital,health care delivery, and scientific explorations all rely on the driving forceof a vigorous state university. By working with other CU academic andresearch units, as well as local, state, and federal funding agencies,commercial business, and nonprofit organizations, CU is creating acollaborative synergy in important areas that will better the wellness ofsociety. The CU Institute of Bioenergetics, the Colorado Initiative inMolecular Biotechnology, the Center for Computational Biology, and theCenter for Pharmaceutical Biotechnology attract intellectual strength toColorado, provide new educational opportunities, and inspire innovativehealth care advances.

University of DenverDenverwww.du.edu

The University of Denver strives to provide the most modern educationaland research facilities in the life sciences. Our history spans the DenverResearch Institute’s development of the first NASA life monitoring sensors,

the establishment of a state-of-the-art forensics laboratory, to the 2003acquisition of the Eleanor Roosevelt Institute with pioneering efforts ingenomics and bioinformatics. In 2004, the School of Engineering andComputer Science unveiled Colorado’s first undergraduate program inBioinformatics and master’s degree in Bioengineering. The interdisciplinarymission of the University enabled the Department of Biology to launch newemphases in Bioengineering, Biophysics, and Cognitive Neurosciencedesigned for molecular biology majors. In addition to strong and qualitycurricula, bioengineering and life sciences at DU carry multimillion-dollar-a-year research studies in the creation of new knowledge and leading edgebiotechnologies to improve quality of life for a worldwide community.

University of Northern ColoradoGreeleywww.unco.edu

University of Northern Colorado (UNC) is a multipurpose institution with awide range of graduate and undergraduate programs. The university’smission is to prepare individuals for advanced study, professional careers,and positions of leadership.

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Accelr8 Technology www.accelr8.comDenverEntered life sciences industry with the acquisition of advanced materialsand instrumentation platforms for ultra-sensitive bio-analytic assays. They focus their product development on applying technologies to leading-edge bio-analytical products. Their initial product is OptArray™microarraying slides.

Accera www.accerapharma.comBroomfieldIs developing novel therapies that target metabolic defects in Alzheimer’sdisease (AD) and may lead to new treatments. These treatments aredesigned to increase energy to neuronal cells and provide raw materials forcholesterol and acetylcholine synthesis. Accera’s revolutionary approach isunique among companies developing treatments for AD.

Aeroponic International www.argrihouse.comBerthoudA NASA SBIR funded biotechnology company supplying bio-pharming,biotechnology, and consulting services. OEM of agri-technology, bio-controlsand BL-3 containment systems. Pesticide-free CLESS systems for space andterrestrial Ag and biopharms for pharmaceuticals, Nutraceuticals and foodcrops.

Affinity Bioreagents www.bioreagents.comGoldenProvides over 2,300 quality guaranteed antibody reagents for over 33research areas. ABR Antibody-on-DemandTM (Custom Antibody Production)Services can create custom antibodies.

Agilent Technologies www.agilent.comEnglewoodDelivers critical tools and technologies that sense, measure and interpretthe physical and biological world.

Agripro Wheat www.agriprowheat.comBerthoudDevelopment and delivery of superior wheat seed genetics in North America.

Agro Management Group www.agromgt.comColorado SpringsAgro joined forces with Sterling Bio-Technologies Corporation to marketbio-based engine lubricants under the Sterling GradeTM brand namethroughout North America.

AKTIV-DRY www.aktiv-dry.comBoulderProvides dry powder processing solutions for the vaccine, pharmaceutical,and biotechnology industries.

Allos Therapeutics www.allos.comWestminsterA biopharmaceutical company focused on developing and commercializingsmall molecule therapeutics for the treatment of cancer. Their productportfolio currently encompasses three novel compounds: EFAPROXYN™(efaproxiral), a synthetic small molecule designed to sensitize hypoxic(oxygen-deprived) tissue, PDX (pralatrexate), a small moleculechemotherapeutic agent (DHFR inhibitor) and RH1, a targeted cytotoxic prodrug.

Alpharma Animal Health www.alpharma.comLongmontManufacturer of generic liquid and topical pharmaceuticals in the U.S.The company also supplies generic pharmaceuticals in selected European markets.

Biotechnology & Pharmaceutical CompaniesAmerican Allied Biochemical www.aablabs.comAuroraSpecializes in the purification and distribution of restrictionendonucleases.

Amgen www.amgen.comLongmontA biotechnology company that discovers, develops, manufactures andmarkets human therapeutics based on advances in cellular and molecularbiology. Amgen Colorado is one of the company’s key operations centers,providing medicines that are changing people’s lives, including EPOGENR(Epoetin alfa), AranespR (darbepoetin alfa), and KepivanceTM (palifermin).

Analytical Development CorporationColorado Springs www.analyticaldevelopment.comA contract analytical chemistry laboratory specializing in bioanalytical andmetabolism research studies for the pharmaceutical and biotechnology,animal health, and agricultural industries.

ApopLogic, Inc. www.apoplogic.comDenverApopLogic is developing therapeutic products for cancer, leukemia andautoimmunity based on its proprietary technologies that target apoptoticcell death pathways.

ARCA DiscoveryAuroraA contract research company that specializes in enhancement ofbiopharmaceutical drug development. ARCA’s specialized expertise is basicand clinical research in the field of heart failure. ARCA has a two-componentbusiness strategy: a) utilizing novel human systems perform contract basicand clinical research in its intramural or extramural laboratories; andb) engage in relationships to complete development of promisingtherapeutic agents.

Array BioPharma www.arraybiopharma.comBoulderA biopharmaceutical company focused on the discovery, development andcommercialization of orally active drugs to address unmet medical needs.Their drug development pipeline is primarily focused on the treatment ofcancer and inflammatory disease and includes several small molecule drugcandidates that are designed to regulate targets in therapeuticallyimportant biologic pathways.

AspenBio www.aspenbioinc.comCastle RockThe focus of the company is to develop products to the point ofintroduction and seek the best potential large pharmaceutical companypartner to penetrate the market. Current products include human andanimal proteins, as well as human and animal hormones.

AstraZeneca Pharmaceuticals www.astrazeneca.comArvadaTheir business is focused on turning good ideas into innovative, effectivemedicines that make a real difference in important areas of health care.

AstroPak Corporation www.astropak.comLongmontThe company specializes in precision cleaning and passivation technologiesfor high purity bio-pharmaceutical systems and related components.

Atlas BiologicalsFort CollinsSupplier of research grade biologicals including Fetal Bovine Serum.

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Aurogen www.aurogen.comFort CollinsTheir technology involves medicine that can reduce health care costs inglobal markets with multibillion dollar potential and without competingcomparable products. The lead product is a newly patented pharmaceuticaltreatment for diabetic neuropathy. A second invention shows thatAurogen’s neurotrophic hormones can act across the blood-brain barrier(BBB) to treat various brain disorders.

Avidity www.avidity.comDenverThe company holds rights to the patented biotin-accepting peptides(AviTag) technology. Currently, this technology is licensed by 7 out of the top 10 leading pharmaceutical companies and is used by researchers in 22 countries. AviTag technology exploits the tight interaction of avidin or streptavidin with biotin for immobilizing, purifying andvisualizing proteins.

BarofoldAuroraAcquired the rights to a patented protein dis-aggregation and re-foldingtechnology from the University of Colorado. The company has received aninitial contract to re-fold malarial proteins currently identifying earlycorporate partners, demonstrating the technology’s benefits with partners’protein targets, identifying strategic partners for equipment developmentand manufacturing, and assessing potential pharmaceutical proteincandidates for development of safer, potentially proprietary products.

BasePeak Analytics www.basepeakanalytics.comLafayetteOffers on-site liquid chromatography/mass spectrometry consulting andtraining to biotech and pharmaceutical clients.

BD-Pasco Laboratories www.bd.comWheat RidgeThe company manufactures microbial diagnostic systems.

Bioexel International, www.bioxelpharma.comA Division of Bioxel PharmaDeveloper, manufacturer and provider of naturally derived, biologicallyactive pharmaceutical ingredients. These “paclitaxel” ingredients are usedin drugs for various forms of cancer.

BioLogixsDenverBiologixs breeds insects for pest control.

BioResponse www.bioresponse.comBoulderNutrient delivery technology. They are dedicated to the research,development and commercialization of unique dietary supplements andfunctional foods. Most recently, BioResponse was awarded a patent for itsdelivery system for highly-absorbable (”bioavailable”) Diindolylmethane.

BioServe Space TechnologiesBoulder www.colorado.edu/engineering/BioServe/index.htmlDeveloping new or improved products through space life science researchin partnership with industry, academia and government.

Blue Sun Biodiesel www.gobluesun.comFort CollinsAn agricultural energy company, developing oilseed energy crops andproduction and distribution networks to bring high-performance biodieselfuel to the west-central United States.

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Bolder BioTechnology www.bolderbio.comWheat RidgeUses advanced protein engineering technologies to create proprietaryhuman protein pharmaceuticals with enhanced therapeutic properties.

Boulder Scientific www.boulderscientific.comMeadA manufacturer of advanced organometallic catalysts, ligands, andco-catalysts.

BP ProteomicsA biotechnology company is developing diagnostic tools and methods thatidentify and quantify proteins, nucleic acids and pathogens from biologicaland environmental samples.

Brotica www.brotica.comFort CollinsProduces Interval33, a termite attractant based on patent pendingtechnology developed at Colorado State University. Interval33 works byproducing the precise level of CO2 that has been shown to attracttermites. Interval33 removes random chance and luck from the termitebaiting strategy by luring termites directly to bait stations. Interval33 isenvironmentally friendly and relatively inexpensive.

CaP Biotechnology www.capbio.comGoldenProduces calcium phosphate hollow microspheres and custom shapedcalcium phosphate materials used at tissue banks, corporate research,and other institutions.

Cardinal Health www.cardinal.com/ptsBoulderOffers oral, topical, inhalation, biopharmaceutical and sterile productsupport. They can provide individual and integrated solutions; developmentservices ranging from discovery to clinical packaging; and capabilities forvirtually every dosage form.

Cargill Health and Food www.cargillhtf.comDenverA developer, processor and marketer of science-based, health promotingingredients for food and dietary supplement industries worldwide.

Cargill Research www.cargill.comFort CollinsWorks with food and pharma customers to develop ingredient systems andexcipient solutions for affordable, healthy and convenient products.

Cell Point www.cellpointweb.comEnglewoodThe company targets metabolic imaging and therapeutic targeting throughnuclear medicine. The company is developing novel radiopharmaceuticalimaging agents, radiotherapeutic agents and local regionalradio/chemotherapeutic drug delivery systems for the diagnosis, treatmentand post therapy assessment of cancer, cardiovascular disease, infectiousdiseases and metabolic diseases.

CHATA www.chatasolutions.comFort CollinsProduces hundreds of standard and custom HPLC mobile phases, dissolutionmedia, buffers and other related reagents. HPLC mobile phases arepackaged in 1, 2 or 5 liter CHEM+NECT bags with a proprietary polymerfilm over-wrap. The over-wrap is virtually impermeable to gas andmoisture, which extends the shelf-life of solutions for months.

Chemins Company www.chemins.comColorado SpringsProduces a wide range of dietary supplements including caplets, tablets,shaped tablets, chewable wafers, two-piece capsules and powdered products.

ClinImmune Labs www.clinimmune.comAuroraThis laboratory provides clinical HLA typing and crossmatching in supportof kidney, bone marrow, heart, lung and pancreas transplant programs.

Colorado Genetics www.coloradogenetics.comLovelandProvides livestock embryo-transfer research, artificial insemination, embryo collection, freezing and transfer, and international import andexport services.

Colorado Histo-Prep www.histoprep.comFort CollinsUtilizing the most sophisticated instrumentation available, their laboratoryproduces high quality slides, clinical chemistry and hematology data andfully integrated and detailed seamless pathology reports.

Colorado Serum www.colorado-serum.comDenverSupplies veterinary biologicals, instruments, laboratory reagents and serumsfor the veterinary industry.

Cytoskeleton www.cytoskeleton.comDenverManufacturer and supplier of biochemicals, reagents and proteins.

DakoCytomation www.dakocytomation.comFort CollinsDevelopment and production of antibodies and instruments for thediagnostic industry. They specialize in the fields of immunocytochemistry,flow cytometry, and microbiology.

Dermik Laboratories www.dermik.comLittletonDevelopment, marketing, and distribution of innovative prescriptionpharmaceutical products. Dermik has created a new division, DermikAesthetics, to market innovative and enduring aesthetic treatments toimprove appearance and well-being.

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Dharmacon www.dharmacon.comLafayetteThe company’s focus and vision is to develop 2’-ACE RNA technology as thestandard for RNA synthesis and to advance RNA oligo-dependent applicationsand technologies. Since the first oligo was shipped in 1996, Dharmaconhas provided tens of thousands of RNA oligos to the research community.Over the years, the RNA market has certified that 2’-ACE RNA chemistry isa clear and definitive leap in technology over all other chemical methodsand is the way to chemically synthesize RNA.

Discovery Partners International www.discoverypartners.comBoulderA participant in drug discovery collaborations. DPI offers services,products, and systems that span the drug discovery continuum, includingtarget characterization, targeted and screening-library design andsynthesis, high throughput and high content screening, lead generationand optimization, gene expression analysis, and protein crystallization.

DMI BioSciences www.dmibio.comEnglewoodA biopharmaceutical company that discovers and develops small moleculeand peptide-based pharmaceuticals and biomarkers for acute and chronic inflammation.

DoveTail Technologies www.dovetailtech.orgAuroraEngaged in research, development and commercialization of patented,immuno-therapeutic technologies with broad applications.

Efficas www.efficas.comBoulderEfficas bioactives will be marketed in products that promote wellness andnutritionally support management of health conditions, including obesity,diabetes, allergies, bone health and inflammation.

Elisa Tech www.elisatech.comAuroraSupplies immunoassays for the measurement of cytokines, growth factors,and lipid inflammatory mediators such as prostaglandins and leukotrienes.ELISA Tech specializes in making custom assays for compounds for whichno commercial assays exist. ELISA Tech also performs all services in atimely fashion so investigators need not wait prolonged periods for results.All reagents and services are unconditionally guaranteed.

Emergent Genetics (Monsanto) www.emergentgenetics.comBoulderA seed and related biotechnology company with operations in the U.S.,Europe and India and has a product focus on cotton, rice, wheat andvegetables. Emergent Genetics was recently bought by Monsanto.

Eppendorf - 5 Prime www.5prime.comBoulderFocus is the development and production of kits for the preparation ofnucleic acids utilizing purification methods and enzymatic amplificationfor the molecular biology research market.

Evolutionary Genomics www.evolgen.comAuroraDevelop technology to identify commercially valuable gene targets bytaking advantage of work already done by nature. The company has a fullyoperational, patented, gene discovery technology platform, the AdaptedTraits Platform, and has been successfully identifying genes for threeyears. EG’s Adapted Traits Platform screens for gene patterns indicative ofadaptation to a strong selection pressure as a powerful data filter to findkey genes.

Eyetech Pharmaceuticals www.eyetech.comBoulderA biopharmaceutical company that specializes in the development andcommercialization of novel therapeutics to treat eye diseases. Eyetechfocuses on diseases affecting the back of the eye.

Front Range LaboratoriesLovelandA full service contract research and development laboratory.

Gene Check www.genecheck.comFort CollinsA biotechnology company who in addition to their research anddevelopment program, produces and markets reagents and kits for researchand offers veterinary genotyping tests for sheep.

Genesis Laboratories www.genesislabs.comWellingtonA full service laboratory provides services to clients in the agrochemicaland pharmaceutical industries.

Genethera www.genethera.comWheat RidgeProvides genetics-based diagnostic and vaccine solutions to meet thegrowing demands of today’s veterinary industry and tomorrow’s agricultureand health care industries.

Genetic Technologies Limited www.gtg.com.auMelbourneAn Australian life sciences company, specializing in the fields of geneticsand genomics. Recognizing the importance of ‘non-coding’ DeoxyribonucleicAcid (DNA), the company’s key business streams include genetic testing,licensing and supporting research programs around the world.

Hauser Laboratories, Division of Microbac www.hauserlabs.comBoulderA research and development testing laboratory that provides research,development, testing, and expert witness services to the followingindustries: pharmaceutical, natural products, dietary supplement, medicaldevice, legal and insurance, and consumer and industrial products.

HemoGenix www.hemogenix.comColorado SpringsThe company’s focus is in stem cell hemotoxicity contract research and thedevelopment and production of clinical diagnostic tools.

Heska Corporation www.heska.comFort CollinsDevelops research-driven solutions that impact the quality of pet care.Their offerings include advanced diagnostics and specialty products thatveterinarians can count on to help them make a difference. They focus onthe canine and feline markets, developing high value products for unmetneeds in veterinary medicine.

IHCtech Histology Services www.ihctech.netAuroraOffers custom histopathology services, specializing inImmunohistochemistry. They test antibodies, molecular probes andbiosensors in tissue and cells.

Insmed www.insmed.comBoulderA biopharmaceutical company focused on the development of drugcandidates for the treatment of metabolic diseases and endocrine disorderswith unmet medical needs. Insmed’s protein manufacturing operation,called Insmed Therapeutic Proteins (ITP), is commissioned for manufactureof the company’s proprietary products.

Institute for Therapeutic BiologyDenverA non-profit research and development institute for drug discovery in thefield of immunology.

InviragenFort CollinsA biotechnology company focused on the development of vaccines foremerging infectious diseases. They have constructed novel vaccines thatprotect against plague, a bioterrorism threat and an endemic disease inmany parts of the world (including Colorado).

Isogenis www.isogenis.comDenverDevelop revolutionary therapies for organ transplantation and geneticdisease. Their Transplantation Tree technology promises to be animprovement over existing therapies because it is administered in acell-specific manner.

Isonics www.isonics.comGoldenA specialty chemical and advanced materials company that develops,commercializes, and markets materials which have been sub-atomicallyengineered to enhance performance. These ultra-pure materials haveapplications in several areas including Medical Diagnostics, Imaging andtherapy, and Drug Development.

Johnson & Johnson/Ortho Biotech www.jnj.comDenverThrough its operating companies, is a comprehensive and broadly basedmanufacturer of health care products, as well as a provider of relatedservices, for the consumer, pharmaceutical, and medical devices anddiagnostics markets.

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GlaxoSmithKline www.gsk.comDenverA research-based pharmaceutical company with a combination of skills andresources that provides a platform for delivering strong growth in today’srapidly changing health care environment.

Global Peptide Services www.globalpeptide.comFort CollinsOffers custom research-grade Peptides and Antibodies. Peptides areproduced in scales ranging from 1mg to multiple grams, and manymodifications/conjugations are available.

GlobeImmune www.globeimmune.comAuroraA biopharmaceutical company has developed an immunotherapy platformtechnology that will allow the production of products for targets that untilnow have been unapproachable by current techniques. The company iscurrently developing products targeted to HIV, hepatitis C, and a numberof cancers. The company’s business model will be to take selected productsthrough proof of concept in human clinical trials and to manufacture atcommercial scale.

Gonex www.gonex.comFort CollinsA development stage company is dedicated to the research, developmentand commercialization of hormonal based health care strategies withapplications for both the human and companion animal markets.

Keen IngredientsFort CollinsManufactures ingredients from an alternative and nutritious crop basedupon technology developed in the Department of Food Science and HumanNutrition at Colorado State University.

Keeton Industries www.keetonaqua.comFort CollinsResearch and development in biological water treatment, aeration, ozoneaeration, solids removal, biofiltration and other new technologies.

Keystone Biomedical www.keystonebio.comWestminsterA pharmaceutical company developing two families of proprietary chemicalcompounds designed to treat cardiovascular diseases, stroke, complicationsof organ transplantation, and cancer.

Lohocla Research CorporationAuroraThe company’s proprietary gene, mRNA and protein diagnostic markersdifferentially ascertain depression, anxiety, manic depressive disorders and addictive disorders. The company uses genomic, proteomic, and genearray technology together with rational drug design to develop diagnosticand therapeutic products in the area of chronic pain, mental and addictive disorders.

MaCleod Pharmaceuticals www.macleodpharma.comFort CollinsDevelops and manufactures anti-bacterial pharmaceuticals for theveterinary industry.

Mantic Biotech www.manticbiotech.comLovelandIn collaboration with researchers at the University of Virginia andStockholm University, has developed proprietary technology and softwareto accurately represent and model protein conformations as discrete structures.

Martek Biosciences www.martekbio.comBoulderDevelops, manufactures and sells products from microalgae. The company’sproducts include: specialty, nutritional oils for infant formula that aid inthe development of the eyes and central nervous system in newborns;Martek DHA™ in the form of nutritional supplements and food ingredientsthat may play a beneficial role in promoting mental and cardiovascularhealth throughout life.

Mayne Pharma www.us.maynepharma.comBoulderA supplier of multi-source injectable pharmaceuticals in the U.S. TheColorado site specializes in the supply of active pharmaceutical ingredientsfor both internal and external markets.

Mediral International www.mediral.comDenverA homeopathic supplier and has now become a provider of hand-processedhomeopathic medicine in the world.

MicroPhage www.micro-phage.comLongmontThe Company obtained the exclusive license to proprietary and patentedhigh-speed bacteria detection technologies that it plans to commercializein worldwide markets including: food safety, water safety, clinical andveterinary diagnostics and detection applications. Specific pathogens thatmay be addressed with the company’s technology include: Escherichia coli,Listeria monocytogenes and Salmonella.

Molecular BioSciences www.molbio.comBoulderThe discovery research division is engaged in the design and developmentof novel therapeutic agents. The Company applies a highly integrated,multidisciplinary approach to drug discovery and has developed proprietarydrug design technologies which have yielded several lead compounds.

Monsanto www.monsanto.comEnglewoodA global provider of agricultural products and integrated solutions for farmers.

MycoLogicsAuroraThe company focuses on infectious human fungal diseases. The company’smycotechnology will be used to discover novel drugs that act by directlyinhibiting fungal cell-wall assembly.

Mycos ResearchLovelandProvides mycobacterial derived biochemicals to the research community,contract research, animal models for tuberculosis and other BSL3organisms, and novel monitoring or vaccine products in the area ofmycobacterial infection.

Myogen www.myogen.comWestminsterA biopharmaceutical company focused on the discovery, development andcommercialization of therapeutics for the treatment of cardiovasculardisorders. Myogen, in collaboration with Novartis, also conducts acardiovascular focused research program.

Navigant Biotechnologies www.navigantbiotech.comLakewoodDeveloping techniques to improve the safety of the blood supply byreducing the pathogens found in donated blood. The Mirasol PathogenReduction Technology (PRT), from Navigant Biotechnologies applies lightand riboflavin to alter the nucleic acids and proteins of pathogens,rendering them inactive.

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NewellinkColorado SpringsDevelops and markets the patent-pending bioenergetics platformtechnologies invented at CU-Colorado Springs. Bioenergetics is the study ofhow cellular metabolism governs the interactions between cells, which arecentral to life, death, and disease.

Novartis Pharmaceuticals Corporation www.novartis.comLittletonThe Pharmaceuticals Division works in the discovery, development,manufacture, and marketing of prescription medicine.

Novus Biologicals www.novusbio.comLittletonDevelops, tests and markets antibodies for research of human diseasessuch as cancer, cardiovascular and neurological disorders.

NutraceutixLafayetteDevelops custom blends and made-to-order formulations in bulk tablet,bottled and other forms for private labels and brands.

Origin USA www.originpharm.comBoulderA contract services organization providing regulatory, drug development,clinical, quality assurance and project management services to thepharmaceutical industry.

OSI Pharmaceuticals www.osip.comBoulderA biotechnology company primarily focused on the discovery, developmentand commercialization of high quality pharmaceutical products that extend life or improve the quality of life for cancer and diabetes patients worldwide.

PAMBEC Laboratories www.pambec.comLovelandResearch based drug discovery company in the field of AIDS. The company’sdrug AIDFARELTM inhibits both the replication and transcription of theintegrated viral DNA known as a provirus by using the drug technologytermed Binary Molecular DNA Clamp (BMC).

Paradocs Biomedical www.paradocsbiomedical.comConiferA contract research and development for integration of advanced moleculartechniques into preclinical and clinical research for both small moleculeand peptide-based drug development.

Peak Analytical www.peaklab.netGoldenA contract laboratory specializing in materials and chemical analysis. Theyperform a variety of molecular and atomic level spectroscopic techniquesto identify failures and defects.

Pfizer www.pfizer.comCentennialDiscovers, develops, manufactures, and markets prescription medicines forhumans and animals and many of the world’s best-known consumer brands.

PhaelixeCastle RockConducts custom research projects for the medical industry and specializesin emerging medical technologies and startups, with current focus onimaging, nanobiotechnology, tissue engineering and telemedicine.

Pharmion www.pharmion.comBoulderA pharmaceutical company that is dedicated to the hematology andoncology communities.

Phasics BioScienceCastle RockA seed-stage contract manufacturing company located in the Front Rangeof Colorado, offers early-stage, funded biotechnology companies processdevelopment services and scalable manufacturing facilities capable ofproviding recombinant protein for the preclinical and clinical trials requiredto receive mandatory FDA approval of therapeutic drugs.

PhosphoSolutions www.phosphosolutions.comDenverFocuses proteins known as phosphoproteins that regulate almost all cellprocesses from cancer to Alzheimer’s.

Pisces MolecularBoulderFocused on applying molecular biology to problems in the aquaticenvironment.

PR Pharmaceuticals www.prpharm.comFort CollinsCreating innovative drug delivery technologies to improve human andanimal health. The company is focused on developing, manufacturing and commercializing pharmaceutical products using controlled-releasetechnology.

Premier Laboratory www.premierlab.comBoulderSupplies histology and pharmacology needs for mission-critical research.They focus on process control and improvement to ensure the delivery of relevant, consistent and reproducible histopathology and pharmacology data.

ProgenityDenverCustom contract manufacturing for the biopharmaceutical industry.

Proligo www.proligo.comBoulderOffers DNA and RNA synthesis reagents for superior oligonucleotidesynthesis: DNA phosphoramidites and CPG, liquid reagents, RNA and 2’OMethyl phosphoramidites and modifications and linkers.

Proneuron Biotechnologies www.proneuron.comEnglewoodA biopharmaceutical company developing therapies for neurologicaldisorders, including spinal cord injury (SCI). Procord is an experimentalcell therapy that is being developed for the treatment of patients with arecent spinal cord injury.

Proteome Resources www.proteomeresources.comAuroraManufacturer and provider of biochemistry tools and services or drugdiscovery and basic research. Presently, the company supplies 98% pureubiquitin enzymes and apoptotic nucleases, as well as custom proteincloning and expression services, to researchers engaged in UbiquitinProteasome Pathway apoptosis and other areas of study.

Provident Pharmaceuticals www.providentpharma.comColorado SpringsA contract manufacturer of prescription and OTC pharmaceuticals. Theirfocus is to provide product development, manufacturing and packaging,and laboratory services for the pharmaceutical industry.

PureVision Technology www.purevisiontechnology.comFort LuptonDevelop proprietary biotechnology processes that can manufacture fiber,ethanol and other high value industrial chemicals from biomass such asagricultural and wood residues. PureVision’s patented fractionationtechnology produces a relatively pure cellulose stream by removing thehemicellulose and lignin fractions from agricultural and waste biomass.

Sentigen Biosciences www.sentigen.comAspenPrimary focus is to apply its proprietary technologies to internal drugdiscovery and development initiatives targeting the largest class ofreceptors in the body, G Protein-Coupled Receptors (GPCRs).

Sentry BiosciencesGreenwood VillageAn emerging biosciences company discovering and developing compoundsthat regulate the process of programmed cell death (apoptosis). Apoptosishas been implicated in 50% of human diseases, including cancer,neurodegenerative disease, and autoimmune disease.

Sirna Therapeutics www.sirna.comBoulderDeveloper of therapeutics based on RNA interference (RNAi) technology.Sirna is leveraging its proprietary technology and expertise in nucleic acidsto develop RNAi-based drugs that selectively target disease-causing genesand viruses.

SomaLogic www.somalogic.comBoulderDeveloping cutting-edge proteomics tools for research and clinicaldiagnostics based on its proprietary aptamer technology. Aptamers wereinvented in the University of Colorado. SomaLogic’s microarrays (aptamerchips) will allow the simultaneous quantitative measurement of tens andultimately, thousands, of proteins. These same aptamers can be used torapidly develop novel assays for individual proteins.

Source Precision MedicineBoulderDedicated to improving drug development and patient care through thepractical application of advanced genomics and related technologies. The Source TheraTraxTM System is based on high-precision molecular assays, targeted disease and drug response databases, and predictive biomedical algorithms.

STA Laboratories www.stalabs.comLongmontProvider of diagnostic services to agricultural biotechnology. STA Genomicsfeatures high through-put molecular marker technology. STA Seed Qualityprovides seed analysis, seed health and IEF electrophoresis hybrid purity services.

Sterling Bio-Technologies Corporation www.sterlinggrade.comSterlingThe company is engaged in commercialization of renewable, bio-basedproducts. Sterling BioTech works with industry, universities and federallaboratories to identify promising new technologies for using plant matteras a key component in manufacturing consumer products. By replacingcertain petroleum products with bio-based materials, they delivereconomic, environmental and societal solutions including the use ofrenewable, agricultural materials instead of dwindling natural resources.

Summit Plant Laboratories www.plantlabs.comFort CollinsThe company is in the specialty micropropagation business, applyinglaboratory plant cloning and greenhouse technologies to produce plantingstocks for breeders, greenhouses, and field crop producers.

Syngenta Seeds www.syngenta-us.comLongmontAn agribusiness committed to sustainable agriculture through innovativeresearch and technology. The company is in crop protection, and ranksthird in the high-value commercial seeds market.

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Pyxant Labs www.pyxant.comColorado SpringsA contract research laboratory specializing in GLP bioanalytical chemistrydevelopment support for life sciences clients.

QLT-USA www.qltinc.comFort CollinsA global biopharmaceutical company specializing in developing treatmentsfor cancer, eye diseases and dermatological and urological conditions.They have combined their expertise in the discovery, development,commercialization and manufacture of innovative drug therapies with ourunique technology platforms to create highly successful products such as Visudyne® and Eligard®.

Replidyne www.replidyne.comLouisvilleA drug discovery company focused on identifying and developing drugs to treat serious infectious diseases. Replidyne is discovering anddeveloping novel antibacterial drugs that act by directly inhibitingbacterial DNA replication.

RMC Biosciences www.rmcbiosciences.comFort CollinsOffers molecular modeling, computer aided drug design, protein-liganddocking models, drug bioavailability models, drug bioactivity models,contract drug discovery research, and high performance computing.

Roche Colorado Corp www.rochecolorado.comBoulderDeveloped manufacturing processes for some of the world’s most complex pharmaceutical compounds. Roche Colorado also is amanufacturing facility, with the flexibility to handle sophisticatedmanufacturing techniques.

Rocky Mountain Diagnostics www.rmdiagnostics.comColorado SpringsA supplier of specialty in-vitro diagnostic test systems and of otherinnovative technologies to the clinical and research laboratory markets.

Rocky Mountain Reagents www.rmreagents.comDenverIn 1951, the company started manufacturing stains, culture media andchemistry solutions for the medical industry. Since that time, the productline has been expanded to include titration reagents, indicators, acids,bases, and a variety of chemicals for industrial uses.

RxKinetix www.rxkinetix.comLouisvilleA specialty pharmaceutical company that uses its proprietary drug deliverytechnologies to develop new medicinal products. The company’s technologyplatforms have produced a lead product candidate for the prevention andtreatment of oral mucositis, RK-0202, that is currently in Phase 2 clinical trials.

Sandoz www.us.sandoz.comBroomfieldSupplier of high-quality generic pharmaceuticals. Sandoz is also operatingtwo Business Units with specific strategic focuses – Anti-Infectives andBiopharmaceuticals.

Sciona www.sciona.comBoulderResearches and develops DNA screens for common gene variants that affectan individual’s response to food, medications and the environment.

Seedex www.seedexseed.comLongmontA research facility specializing in development, production and sales ofsugar beet, corn, and other seeds; has developed sugar beet hybrids.

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Taligen TherapeuticsAuroraThe company employs innovative technologies to manipulate complementproteins of the immune system to inhibit inflammation and to targetinhibitors of the inflammation to specific sites of tissue injury. Bytargeting the complement system, Taligen’s technology inhibitsinflammation proximal or upstream in the inflammatory cascade, such thatblockade at a single step results in the down-regulation of multipleeffector mechanisms.

Tapestry Pharmaceuticals www.tapestrypharma.comBoulderA company focused on proprietary therapies for the treatment of cancer.They are also actively engaged in evaluating new therapeutic agents andrelated technologies for in-licensing.

Theravance www.theravance.comDenverDiscovers and develops medicines in large markets; their drug discoveryefforts are based on their multivalency.

Thinc Pharmaceuticals www.thincpharmaceuticals.comAuroraThe company is focused on the development of iron-chelating therapies(with applications in Oncology, Hematology, and Gastro-Intestinaldisorders) and drugs and drug therapies for the treatment ofNeurodegenerative Diseases.

Transgenomic www.transgenomic.comBoulderProvides research tools and related consumable products to the lifesciences industry for the synthesis, separation, analysis and purification ofnucleic acids and a wide variety of nucleic acid-based specialty chemicals.Transgenomic’s biosystems segment offers its WAVE® Systems andassociated consumables.

U.S. Pharmacal www.uspharmacal.comErieResearch, development and sales of topical pharmaceuticals for the senior community.

Vitro Diagnostics www.vitrodiag.comAuroraHas recently launched a product line, VITROCELL™, consisting of novelHuman Cell Lines for Research and Development.

Able Planet www.ableplanet.comFort CollinsThe Able Planet™ micro-technology was designed to be a hearing aidcompatible and hearing accessible technology. The Able Planet™ micro-technology when installed into a telephone receiver, hands-free unit or any consumer audio equipment provides for enhanced telephoneaccessibility for people with mild to severe-to-profound hearing loss.

AbleLink Technologies www.ablelinktech.comColorado SpringsAddresses the need for well-researched cognitive support technologies forindividuals with intellectual disabilities.

About Packaging Robotics www.aboutpackagingrobotics.comThorntonProduces affordable robotic package handling systems. Their products areengineered to open, fill, transport, seal, code and label as a variety ofpre-made pouches and bags. Their line of packaging and systems for ondemand product identification is currently used in the medical, industrialand food industries.

Medical Device Companies

Accellent www.accellent.comArvadaOffers a comprehensive menu of outsourcing solutions to the medicaldevice market, including design and engineering services, precisioncomponent production, finished goods assembly, and complete supplychain management.

Access Battery/Alpha Source www.accessbattery.comElizabethHas been assembling, manufacturing and supplying America’s leadingHospitals, Medical Centers, Fire, EMS and Police Departments with theirportable battery needs.

Accu-Tube Corporation www.accutube.comEnglewoodManufactures top quality standard and custom size stainless steel tubing.Sizes from small diameter hypodermic medical tubing .009” OD (.23mm) to.375” OD (9.35mm).

Actall Corporation www.actall.comDenverEngineers and manufactures wireless personal duress systems. ActallCorporation’s experienced engineering staff continues to lead research anddevelopment toward integration of many types of wireless and hard wiredproducts such as Biometric Identification.

Ada Technologies www.adatech.comEnglewoodDevelops and commercializes technology. They have an active researchprogram focused on mercury control technology, instruments and sensors,water treatment and a new business venture they call PhysioNetics®.

Advanced Cosmetic Intervention www.acisurgery.comParkerAn advanced medical technology company developing innovative devicesand minimally invasive surgical techniques for plastic and facial plasticsurgical procedures.

Advanced Medical CeramicsGoldenA manufacturer of hip and spinal implants for orthopedic companies. Theymake copy exact components and devices. They are the spherical bearingsurface experts. Their materials provide highly wear resistant options topatients who want to maintain an active, healthy lifestyle.

Advanced Power Technology www.advancedpower.comParkerDesigns, manufactures, and markets high power, high voltage, highperformance semiconductors for both switching and RF applications.Their products are powering the next generation high power systems forindustrial applications such as advanced medical imaging systems, lasers,semiconductor process equipment, as well as military and aerospace power systems.

Alcohol Countermeasure Systems www.acs-corp.comAuroraManufacturer of alcohol sensing and breath test instruments. The companyis also engaged in the research and development of breath analysistechniques to introduce leading designs of breath analysis products to suita variety of applications.

AlloSource www.allosource.comCentennialDevelops processes and distributes life-enhancing bone and tissueallografts to the medical community.

Allpro www.allprodental.comBroomfieldProduces a large selection of non-latex prophy cups.

AlphaSnifferBoulderDevelops technologies to detect contaminants, toxins and other chemical agents.

Amidex www.amidexmedical.comLakewoodManufacturer of the AmilyserTM, which collects non-volatile aerosols fromexhaled breath and produces results within five minutes, then continues tomonitor breathing circuits to provide time-resolved trends of analytes.

Anatel Corporation www.anatel.comLovelandThe company’s instrumentation excels in deionized (DI) or ultrapure (UPW)water monitoring.

Animal Care Systems www.animalcaresystems.comLittletonThe company has invested heavily in research and development to bring abetter mouse cage to the life science industry.

Animark www.animark.usAuroraThe company provides electronic breeding equipment business.

Auri-Stim Medical www.net1000device.comDenverThe NET-1000 device offers a viable alternative therapy to millions ofindividuals who suffer from Migraine Headaches, Hormonal Migraine,Chronic Headaches, Premenstrual Syndrome (PMS), Nicotine and NarcoticsAddictions.

Avantes www.avantes.comBoulderA company in the field of low cost spectroscopy and fiber optic applications.They offer miniature spectrometer systems for on-line measurements andanalysis, usually consisting of a light source, fiber optic cables and probesand a spectrometer for the analysis of the light.

Baxa Corporation www.baxa.comEnglewoodA medical device company that continually improves and maximizes long-termvalue through lifetime partnerships with customers. They provide innovativeproduct solutions globally to handle and administer fluid medications. Baxamakes a lasting contribution to society by enabling health care providersto treat patients with complete safety and effectiveness.

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BD Diagnostic Systems www.bd.comWheat RidgeA medical technology company that serves health care institutions, lifescience researchers, clinical laboratories, industry and the general public.BD manufactures and sells a broad range of medical supplies, devices,laboratory equipment and diagnostic products.

Bell Dental Products www.belldental.comDenverDesigns, develops, and manufactures precision dental equipment based onelectric motor technology.

BioCare Systems www.biocaresystems.comParkerAn emerging medical device company founded to develop and marketpatent-protected, FDA cleared low level light products in the infraredspectrum (IR Therapy) to decrease pain.

Biofeedback Systems www.users.qwest.net/~pitchj.comBoulderBFS, Inc. is engaged in the design, manufacture, sales and service of acomplete line of biofeedback hardware and software including subliminaland supraliminal audio self-help cassette programs. The company is an FDA registered medical device manufacturer.

Biophorix www.biophorix.comAuroraResearch and development company for the intelligent design of life saving drugs.

Biotrol International www.biotrol.comLouisvilleManufactures and markets Infection Control and Preventive products forthe dental industry.

bioZhena www.biozhena.comBellevueAn early-stage bioelectronic technology and informatics company focusingon female reproductive health.

Braun BioSystems www.braunbiosystems.comCentennialExpanding the cost savings and therapeutic benefits presently experiencedby managing anticoagulants in the cardiovascular market to many otherhealth care venues where this technology can provide similar benefits.

Byers Peak www.byerspeak.comWheat RidgePresents a simple alternative to low/mid volume contract manufacturingand outsourcing services for today’s cost-conscious economy. They are anISO 9001:2000 Certified/FDA Registered Electro-Mechanical TurnkeyContract Manufacturer of Finished Devices, including design support,product release assistance, refurbishment, field service, end-userdistribution, and worldwide sourcing.

Canberra Industries www.canberra.comArvadaManufacturer of radiation detection and analysis instrumentation. Supplierof integrated nuclear gamma and alpha spectroscopy instrumentation.Canberra maintained its position in its existing markets and expanded intoareas such as health physics, computer-based spectroscopy, and neutroncounting instrumentation through a series of acquisitions.

Cardio-Optics www.cardio-optics.comBoulderThe company has invented and developed Trans-Blood Vision™ (TBV™), anenabling, platform technology that provides direct, real-time, optically-based vision through blood and brings the physician’s sense of sight intoplay in blood-filled areas.

Care Electronics www.careelectronics.comBoulderMobility Monitors alert a caregiver when a resident attempts to leave the safety of a chair or bed. Mobility Monitors use an adjustable cordclipped to the clothing which activates an alarm. There are two models to choose from.

Caroba Plastics www.caroba.comEnglewoodA full service custom injection molder specializing in the demanding needsof the medical and high technology industries.

CeMines www.cemines.comGoldenCeMines has developed its breakthrough Molecular FingerPrinting™ bloodtest for the early detection and optimized treatment of a variety of cancersand other immune diseases. Based on monitoring disease-specificmolecular changes in gene regulatory machinery. Its minimally invasivediagnostic tests will provide accurate, early detection of most widespreadcancers including: lung, breast, prostate and gastrointestinal.

Certol International www.certol.comDenverTheir mission is to provide patients and health care professionals withinnovative products and responsible solutions to the complicated infectioncontrol challenges.

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The Colorado BioScience Associationis the heart of Colorado’s fast growing

life science industry.

• Speaks with a single voice on behalf of the industry.

• Provides educational programs to help the industry compete.

• Works with government officials to strengthen the industry.

• Acts as a catalyst to increase academic and industry cooperation.

• Helps Colorado’s economic development agencies attract, grow and create life science companies.

Colorado BioScience AssociationAdvance Colorado Center

1625 Broadway, Suite 950, Denver, Colorado 80202303-592-4073

www.cobioscience.com

CLP Microtechnologies www.clpmt.comBoulderA start-up based on University of Colorado technology, specializes in themicrofabrication of polymeric devices with diverse chemical, electrical andmechanical properties. These technologies will increase CLP’s ability todesign and fabricate small, inexpensive devices for diverse applications.

COBE Cardiovascular www.cobe.comArvadaCOBE Cardiovascular, partnered with Sorin Biomedical to an entity devotedto meeting the needs of the cardiopulmonary market. From oxygenators,cardioplegia systems, tubing packs, and biocompatible surfaces toheart/lung and auto-transfusion systems.

Cochlear Americas www.cochlearamericas.comDesign, manufacture and distribution of hearing implants. Nucleus Freedomcochlear implants are designed to mimic the intricacies of natural hearing.

COMEG Endoscopes, U.S.A. www.comeg.deDenverDevelopment and manufacture of high-grade endoscopes and accessories.

Confi-Dental Products www.confi-dental.comLouisvilleContract manufacturer of quality dental cements, composite resins andinjection molded plastics.

CoorsTek www.coorstek.comGoldenUsing advanced technology, materials, manufacturing and assembly todevelop their medical customer’s ideas.

Corgenix Medical Corporation www.corgenix.comWestminsterThe company develops and manufactures innovative diagnostic test kitsused to aid in the diagnosis of specific immunological diseases.

CytoLogic www.cytologic.comFort CollinsThe company’s technology, UNLEASH™ Immunotherapy, uses a medicaldevice to treat solid tumors. In a process similar to kidney dialysis,UNLEASH™ Immunotherapy selectively removes blood-borne inhibitors thatprotect tumors from the body’s own immunological defenses.

Delphi Medical Systems www.delphimedical.comLongmontFocuses on medium volume, high complexity systems for the production ofmany types of instruments.

Dentsply Friadent/CeraMed www.dentsply.comLakewoodDesigns, manufactures and markets dental implant and surgical devices.

Denver Biomedical www.denverbiomedical.comGoldenDesigner, manufacturer and distributor of specialized medical products forfluid management of pleural effusion and ascites. Our Pleurx pleuralcatheter and the Denver pleural and ascites shunts contribute to thecompassionate palliation of the patient.

Denver Instrument www.denverinstrumentusa.comDenverThe company designs and manufacturers analytical balances,electrochemistry instruments, moisture analyzers, and titration controllers.

Denver Optic Company www.eyeprosthetics.comEnglewoodSpecializes in the fitting and fabrication of two types of ocular prosthesis.The custom made ocular prosthesis is made for the patient who has hadtheir eye either enucleated or eviscerated. The custom made scleral covershell is made to fit over the patient’s blind disfigured eye. Both are madeto cosmetically restore symmetry to the patient’s companion eye.

Die Cut Technologies www.diecuttech.comNorthglennThey engineer, design, and manufacture the finished product using a myriadof materials. Their products and services meet customer specifications. DieCut Technologies works to design, prototype and fabricate non-metallicparts that improve the manufacturing processes.

DNA-IntelliGen CorporationMonumentDevelops and applies current biometric technology into products designedto provide improved security measures to thwart identity theft, providemore robust personal security.

DNTLworks Equipment Corporation www.dntlworks.comCentennialManufacturer of portable, mobile and self-contained dental equipment.

Eagle Research www.eagleresearchllc.comLakewoodDesigns, manufactures, and markets alternative health products. Theirproduct line ranges from nutritional supplements to electronic equipmentfor the alternative health industry.

Elantec Med http://members.aol.com/lmallen/homepag.htmGoldenThe company is engaged in product development for itself and for otherson contract, is a manufacturer, and is a drug delivery system research and development company. Its products are sold domestically and internationally.

Eldon James Corporation www.eldonjames.comLovelandDesign and manufacture of tubing and hose fittings used worldwide ascomponents in medical devices and water filtration systems.

Ellab Inc. www.ellab.comCentennialManufacturer of complete Thermal Validation Solutions for food andpharmaceutical industries and other industries where thermal processinginvolves safety, energy savings, improvement of quality, optimization andwhere accurate and complete documentation is essential.

Encision www.encision.comBoulderDesign and manufacture of AEM Laparoscopic Instruments. Based on theirpatented active electrode monitoring technology, AEM Instruments are anemerging Standard of Care greatly benefiting patient, surgeon andoperating room staff.

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Encynova International www.encynova.comBroomfieldDesigns and manufactures superior fluid control systems for a broad rangeof metering and dispensing applications.

Evergreen Research www.evergreenresearch.comGoldenContract product development emphasizing medical devices.

Falcon Rehabilitation Products www.falconrehab.comColorado SpringsDesigns and manufactures seating solutions for wheelchairs. Falcon’sservices are especially helpful for patients with Multiple Sclerosis (MS) dueto the changes they experience in body positioning.

Ferraris Respiratory www.ferrarismedicalusa.comLouisvilleDeveloper and manufacturer of respiratory care products and services. Theyspecialize in cardio-pulmonary diagnostics, asthma management and othernon-invasive respiratory solutions.

Fischer Imaging www.fischerimaging.comDenverDesigns, manufactures, and markets imaging systems for the screening anddiagnosis of breast disease.

Gambro www.gambro.comLakewoodA global medical technology company in renal care, services, products,and blood component technology. Gambro Renal Products develops andsupplies hemodialysis, peritoneal dialysis and acute dialysis products,therapies and services.

Gambro BCT www.cobebct.comLakewoodThe company’s Trima system is the first automated blood collection systemto collect a combination of leukoreduced red blood cells, platelets andplasma, helping blood centers be more efficient than ever before.

Genesee BioMedical www.geneseebiomedical.comDenverManufacturer of cardiac surgery instruments and devices.

Gnathodontics www.gnatho.comWheat RidgeSpecializing in functional dentistry, advanced implant work, precisionpartial dentures, combination cases and metal-free fixed restorations.

Guidant www.guidant.comCastle RockDesign and development of cardiovascular medical products. Their deviceshelp patients with heart disease return to active and productive lives.

Hach Company www.hach.comLovelandManufactures and distributes analytical instruments and reagents used totest the quality of water and other aqueous solutions.

Halleck-Willard www.hwiresearch.comFredrickCustom development of nearly a hundred different products in industriesincluding medical, telecommunications, industrial controls, computerperipherals and food and beverage.

HealtheTech www.healthetech.comGoldenDevelops and markets technologically advanced and proprietary diagnosticdevices and software that measure and monitor health parameters.

HEI Advanced Medical Operations www.heii.comBoulderA full service developer and manufacturer of high performancecomponents, medical software, medical devices, and non-medical products.HEI produces microcircuits and subsystems for hearing and medicalapplications, communications, and high-speed data processing.

Hirsh Precision Products www.hppi.comBoulderA contract manufacturer of precision-machined and assembled components.The company attracts the attention of industry with their quality programand inventory reduction strategies. Industries served include Medical,Automotive, Communications and Instrumentation.

Hosuk America www.hosuk.netAuroraManufactures syringe and packaging products for the medical community.

Ideatrics www.ideatrics.comBoulderDevelops hand held manually operated mechanical instruments andprovides consulting services to organizations involved in the design,manufacture and distribution of medical devices.

InDevR www.indevr.netBoulderDedicated to innovating technological advances in the area of biomedicalinstrumentation. Their mission is to discover and apply new technologiesto problems in clinical and biochemical analysis with the goal ofdeveloping and manufacturing instruments.

Innovative Machining www.innovativemachininginc.comWheat RidgeProduce specialized parts in quantities from single prototypes to highproduction runs for engineers, scientists, inventors, technicians andmechanics.

Ionic Fusion www.ionicfusion.comLongmontDesigns, manufactures, distributes, and services equipment for theirproprietary process utilizing Ionic Plasma Deposition (IPD). The IonicPlasma Deposition Process impregnates many metals and ceramics intosubstrates enhancing the surface characteristics.

Ionics Instruments www.ionicsinstruments.comBoulderManufacturer of instruments used to measure total organic carbon (TOC)in water. In addition, they offer advanced total carbon analyzers, boronanalyzers, oxygen demand analyzers, sulfur and nitrogenchemiluminescence detectors, nitric oxide analyzers, oil on watermonitoring systems, and certified reference materials.

IPAX www.ipaxinc.comEnglewoodAssembly and packaging of medical products.

JMST Systems www.hyperquan.comColorado SpringsA manufacturer of high performance chemical analysis instruments. SinceJMST is the original source of the designs manufactured, JMST can offerthe highest performance instruments for most applications of opticalmonitoring, liquid delivery, robotic sampling, and liquid fraction collection.

Jorgensen Laboratories www.jorvet.comLovelandRun by veterinarians who have used these instruments in veterinarypractice, design and manufacture instruments which are used regularly inthe animal health field.

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Kestrel Labs www.kestrellabs.comBoulderResearch and development projects, consulting, and contract developmentof innovative, patient monitoring concepts and other medical technologies.Kestrel Labs focuses on finding innovative medical device concepts.

Kuschall www.kuschallna.comLongmontResearch, development, and manufacturer of ultra-lightweight rigid andfolding frame “personal mobility vehicles” (wheelchairs).

LaBac Systems www.labaconline.comDenverDesigns and builds high quality, innovative quadriplegic seating systems.

Lenox MacLaren Surgical Instruments www.lenoxmaclaren.comLouisvilleManufacturer of custom surgical instruments.

Lexicor Research Center www.lexicor.comBoulderManufactures an EEG data acquisition medical device called the DigitalCortical Scan. The company also offers quantitative EEG data analysisthrough its DataLex Reporting Service.

LogiSensFort CollinsDelivers products and services for stress management and peak performance.Stress is a leading cause of illness and consequently of increased healthcare costs. The company’s first product uses scientifically proven biofeedbacktechnology in an office/PC environment.

McKinley Medical www.mckinleymed.comWheat RidgeAn infusion technology company that offers innovative solutions designedto meet the growing needs of the worldwide health care market for highquality drug delivery.

Medegen Medical Products www.medegen.comNorthglennDevelops, manufactures and markets disposable medical products. MMPfocuses on medical disposable/reusable products that are not subject totechnology innovation costs. MMP manufactures three product lines:Patient Utensils, Laboratory Disposables and Procedure Kits.

Medical Modeling www.medicalmodeling.comGoldenProduces highly accurate 3-D physical models of human bone structurefrom imaging such as CT or MRI.

Medispec Ltd www.medispec.comGlendaleDevelops, manufactures and markets high-tech medical equipment for thefields of Urology, Uro-Gynecology and Orthopedics.

Medivance www.medivance.comLouisvilleWorking in the field of therapeutic temperature management with thedevelopment and introduction of its first product platform — the patentedArctic Sun Temperature Management System.

MedSource Technologies/InstruMedEnglewoodManufactures a line of precision surgical instruments and componentsmade from strip metal, wire, tubing, and nonferrous materials, includingelectrodes for use in general surgical, laparoscopic, endoscopic,arthroscopic, and gynecological procedures.

Medtronic SNT www.medtronic.comLouisvilleProducer of pacing technology. Medtronic is a medical technology company,providing lifelong solutions for people with chronic disease.

Meinhard Glass Product www.meinhard.comGoldenNebulizer design, the company’s principal goal is to produce finer, morenarrowly sized dispersed aerosols while maintaining the high quality, lowcost and simplicity of design and operation that characterize theMEINHARD® nebulizer.

Meritech www.meritech.comEnglewoodProviding employee hygiene equipment to the medical cleanroom. Usingthe latest technology, Meritech provides a no-touch, automated method ofwashing and sanitizing bare hands, gloved hands, boots, and shoes.

Mesa Laboratories www.mesalabs.comLakewoodAcquires, develops, manufactures and markets high-quality, computerbased, and electronic measurement instruments. Mesa’s products are usedto assure product quality and to solve problems in niche markets inindustrial, pharmaceutical and medical applications.

Metafluidics www.metafluidics.comGoldenIs focused upon developing chip-top cell handling instrumentation. Theirfocus is a chip-top microfluidic device capable of completely automatingthe processes involved in therapeutics screening of cellular suspensionswithin a single high-throughput, disposable device.

Nanogen www.nanogen.comFt. CollinsProvides instrumentation for multiplexed detection in genetic andinfectious disease testing. The NanoChipâ 400, an electronic microarrayplatform, fully automates highly complex assays. Analyte Specific Reagentsusing MGB EclipseTM probes are available for real-time PCR assays.

Nervonix, Inc. www.nervonix.comLongmontA development stage medical device company, which has invented,patented, and prototyped a break-through nerve imaging technology thatoperates non-invasively at the skin surface to accurately locate and imageperipheral nerves.

Optibrand www.optibrand.comFort CollinsProvides U.S. and international livestock producers with a fraud-resistant,inexpensive system to add value to their product. By positively identifyingindividual animals from birth and throughout the food processing chain,the Secure Identity Preservation system helps assure food safety, controlthe spread of animal disease and add value to branded premium products.

OrthoNetx www.orthonetx.comSuperiorDevelops, manufactures, markets, and supports proprietary medical devicesfor distraction osteogenesis to treat human bone-related tissue deficienciesand deformities, both congenital and acquired.

Otologics www.otologics.comBoulderDeveloping and commercializing surgically implantable alternatives toconventional “in the ear” hearing aids, to better address the needs of theapproximately 6.9 million people in the world with significant hearing loss.

Oval Window Audio www.ovalwindowaudio.comNederlandProduces induction loop assistive listening systems and unique visual andvibrotactile technologies that help the deaf and hard of hearing.

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Pare Surgical www.paresurgical.comEnglewoodA surgical instrument development, manufacturing and distributioncompany. The company is dedicated to the development of innovativesurgical instruments which also result in a cost savings to hospitals andsurgical centers.

Parker Medical www.parkermedical.comEnglewoodA company devoted to saving lives by improving the technology fortracheal intubation in the hospital and pre-hospital setting.

Particle Measuring Systems www.pmeasuring.comBoulderParticle Measuring Systems has over 30 years’ experience designing,manufacturing, and servicing precision microcontamination monitoringinstrumentation and software used for detecting particles in aerosols,liquids, slurries, gas streams and vacuum processing environments as wellas surface molecular contamination monitoring.

PCC/Advanced Forming Technology www.pcc-aft.comLongmontThe company designs and manufactures metal injection molding (MIM).Metal Injection Molding (MIM) has proven to be a viable alternative toolder forms of manufacturing.

Peak Robots www.peakrobotics.comColorado SpringsAn engineering-rooted company that manufactures robots, specialequipment, and turnkey automated systems for a variety of industriesincluding: biotech, electronics, medical, semiconductor, etc.

Pernicka www.pernicka.comFort CollinsCustom manufacturing of products, parts or prototypes to precisespecifications whether a single test unit or a large production run is needed.

Physiodynamics www.therastim.netEnglewoodTheraStim® is a unique, wall plug-in and battery powered electricalneuromuscular stimulation modality. It is a treatment of soft tissuerehabilitation. TheraStim® has introduced an exclusive direct currentwaveform not found in any conventional electrotherapeutic muscle stimulators.

Piko Healthcare Products www.pikohealthcare.comLouisvilleDesign and development of low-cost, intelligent, electronic medical devicesto service the needs of the global homecare market.

Point Technologies www.pointtech.comBoulderSpecializes in precision manufacture of critical biomedical metalsubcomponents. Core technologies include electrochemical pointing,plating, burr-free cutting and micro-machining of small diameter wire and tubing.

Porta-Lung www.porta-lung.comDenverThe Porta-Lung provides noninvasive ventilatory support for long-termrespiratory patients who need more portability than the iron lung allows,while maintaining the same level of ventilating efficiency.

Precision Glassblowing www.precisionglassblowing.comCentennialPrecision Glassblowing is the source for all ICP and General Laboratoryglassware needs. Precision Glassblowing is one of the largest providers ofcustom and OEM scientific glass.

Preferred Medical Products www.pmpcolorado.comEnglewoodSpecializes in the manufacture of stainless steel medial components forhypodermic needles and lancet type products.

Probetronix www.probetronix.netColorado SpringsManufacturer of oscilloscope probes.

Pro-Safe Products www.prosafeproducts.comGrand JunctionCapabilities include customizing existing products, creation of newproducts/prototyping; custom packaging and labeling; contract design andmanufacturing; fulfillment services and design and engineering.Manufacturing is limited in sewn products.

Protomed www.protomed.netArvadaProtoMED models are used for presurgical planning of complexreconstruction cases and for patient fitted prosthesis design.

Quest Product Development www.quest-corp.comEvergreenProvides full service engineering and product development services for themedical device industry.

Radiological Imaging Technology www.radimage.comColorado SpringsRIT received FDA clearance on RIT113 radiation therapy film dosimetry.RIT113’s innovations provide clinical and research physicists with the firsthigh precision automated QA tool for advanced radiation therapies.

Rand-Scot www.easypivot.comFort CollinsDesigns and manufactures the EasyPivot lift, which is a streamlined”transfer machine” designed for safe, efficient transfers that contribute tothe health of the patient as well as the health of the caregiver.

Reynolds Polymer Technology www.reynoldspolymer.comGrand JunctionManufactures superior quality cast acrylic cylinders for hyperbaric chamber manufacturers. The quality assurance and precision in moldingacrylic cylinders are applied also to the production of hemispheres andspheres for the PVHO’s (Pressure Vessels for Human Occupancy) and tourist submersibles.

RJD Machining www.rjdmachining.comParkerProvides components to medical equipment, aerospace, electronic components, optical, measuring devices, pumping and electro-magnetic companies.

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Rocky Mountain BiosystemsGoldenCombines physical science and biotechnology to design products thatmake people “look and feel betterTM.” RMBI’s proprietary high frequencyenergy conversion systems temporarily or permanently modify tissues fortransdermal and deposition drug delivery, and for cosmetic skinresurfacing.

Rocky Mountain Orthodontics www.rmortho.comDenverDeveloping the first set of prefabricated orthodontic appliances. Aftermuch clinical research and experimentation, the first preformed bands,attachments, stainless steel wire and welder were introduced.

Sandhill Scientific www.sandhillsci.comHighlands RanchManufacturer of medical instrumentation for gastroenterologists andendoscopic surgeons.

Scientech www.scientech-inc.comBoulderManufacturer of semi-micro balances, analytical balances, semi-analyticalbalances, and toploading balances.

Shippert Medical Technologies www.shippertmedical.comCentennialManufactures and distributes medical disposable products and instruments.The company serves the Ear, Nose and Throat, Plastic Surgery,Emergency/Trauma Care, Family Practice, Pediatric, and Dermatology fields.

Sienco www.sienco.comArvadaA small manufacturing company focused on providing tools for hemostasismonitoring and viscoelastic evaluations. Their mission is to develop andcommercialize niche whole blood/platelet coagulation management toolsfor the clinical and research communities.

Silverglide Surgical Technologies www.silverglidesurgical.comBoulderManufactures and distributes electrosurgical instruments for stoppingbleeding in the brain, spine and other delicate surgical fields. Allinstruments incorporate the SILVERGlide® non-stick technology. Thistechnology virtually eliminates the frustrating problem of tissue stickingto the instrument, especially during bipolar electrosurgery.

Sonora Medical Systems www.4sonora.comLongmontSonora is an ISO-9000 certified and FDA registered provider of high quality products and services to the diagnostic ultrasound and MRI markets.

Sontec Instruments www.sontecinstruments.comEnglewoodHas been supplying the medical industry with the finest in surgicalinstrumentation for all specialties. They offer complete in-house repairservice and custom instrument manufacturing in addition to their alreadybroad line of instruments.

Sound Surgical Technologies www.vaser.comGoldenCreators of the VASER® System and the LipoSelectionSM procedure, focuseson ultrasonic technologies and related techniques for aesthetic surgery.

Spectranetics www.spectranetics.comColorado SpringsDevelops, manufactures and markets the ”cool” ultraviolet excimer lasertechnology for multiple cardiovascular procedures to physicians andhospitals worldwide.

Summa Design www.summa-design.comMontroseA contract design and development company focused on the medicaldevice market. They provide the entire spectrum of medical businesssupport, including product design and development, business development,international distribution, quality system and regulatory consulting.

Summit Doppler Systems www.summitdoppler.comGoldenManufacturer of ultrasound Doppler systems used to detect fetal heartbeatand to monitor peripheral arterial and venous blood flow. The peoplebehind Summit have been developing fetal and vascular Dopplers for overthree decades and are proud to introduce the most advanced Dopplersystems available today.

Sunrise Medical www.sunrisemedical.comLongmontManufacturer of homecare and extended care products. The company’sproducts have been built from many popular brands in the homecareindustry including Quickie, Sopur, Jay, DeVilbiss, Hoyer, Guardian, Coopers,Oxford and Joerns.

Synthes USA www.synthes.comMonumentThe company develops, produces and markets instruments, implants andbiomaterials for the surgical fixation, correction and regeneration of thehuman skeleton and its soft tissues.

T.R.S. www.oandp.comBoulderDevelops, manufactures and markets body-powered prosthetic devices.Designs and builds only high quality technology for persons missing a hand(s).

Takeshiba TechnologiesPuebloDevelops and manufactures a hand-held device that uses ultrasoundtechnology to measure how much urine is in the bladder. The device emitsultrasound waves to measure the size of the bladder, which shrinks andgrows based on how much liquid is in there.

Tapeless Wound Care ProductsEnglewoodManufactures and distributes a system of patented secondary wounddressing retention devices, offering an alternative to traditional secondarywound dressings, including tape, gauze, elastic wraps and elastic netting.

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Tartan Orthopedics www.tartanortho.comNorthglennManufactures an entire line of orthopedic products such as sacro lumbarbelts, dorsal lumbar belts corsets and moldable insert, Ottenberg styleelbow splint, pelvic traction belts, arm slings, cervical collars,acromioclavicular splints, and ankle supports.

TDA Research www.tda.comWheat RidgeDevelopment and commercialization of a variety of components anddevices, including single-use devices, life support equipment, fuel systemsand MEMS-based devices.

Tech-X Corporation www.txcorp.comBoulderCommitted to scientific and technical excellence and innovation. Theyprovide technical solutions through collaboration and product developmentand are dedicated to advances in science and engineering. Their businessconsists of grant funded scientific R&D projects and scientific software products.

Thermo Electron www.thermo.com/pocArvadaSupplier of analytical laboratory instruments. Thermo’s Point of Care &Rapid Diagnostics business unit develops highly sensitive and specificpatient diagnostic tests for rapid detection of respiratory, gastrointestinal,sexually transmitted diseases.

TMJ Implants www.tmj.comGoldenDesign and manufacture of alloplastic implants for the treatment oftemporomandibular joint disorders and injuries. The company manufacturesboth stock and custom devices for partial and total TMJ joint replacement.

Touch of Life Technologies www.toltech.netAuroraThis early stage company commercializes scientific applications based onadvances in human anatomy simulation.

Transtracheal Systems www.transtracheal.comEnglewoodManufactures and markets respiratory therapy products including the SCOOPtranstracheal oxygen therapy system.

Trelleborg American Variseal Corporation www.trelleborg.comBroomfieldSpring Energized Polymeric Sealing Systems which can be used to sealpackaging for biohazard containment/disposal.

Valleylab www.valleylab.comBoulderProduct development by designing, manufacturing, and marketing advancedelectrosurgery systems and accessories worldwide.

Value Plastics www.valueplastics.comFort CollinsDesigns and manufactures plastic tubing components including Luers, LuerAccessories, Large Bore, Tube-to-Tube, Threaded, Panel Mount, BloodPressure and Bondable Fittings.

Water Pik Technologies www.waterpik.comFort CollinsDeveloper, manufacturer and marketer of revolutionary health care productsfor the entire family.

WestMed www.westmedinc.comEnglewoodDesigns, manufactures and markets leading quality medical devices forAnesthesia and Respiratory professionals.

B i o s c i e n c e C O L O R A D O

ARCHITECTSThe Abo Group, Inc.www.aclparchitecture.com

Christopher Carvell Architectswww.carvell.com

Maynard/David Partnershipwww.maynarddavid.com

RNL Designwww.rnldesign.com

Sherrill & Companywww.sherrillco.com

CONSTRUCTION & FACILITIESAdvanced Lab Conceptswww.alc-corp.com

Cator, Ruma & Associateswww.catorruma.com

Haselden Constructionwww.haselden.com

InterTech Planning and Design

ISEC Laboratory Serviceswww.iseinc.com

Lauth Property Groupwww.lauthproperty.com

LS Planningwww.lsplanning.com

Martin / Martin Consulting Engineerswww.martinmartin.com

M.A. Mortenson Companywww.mortenson.com

Outsource Facility Solutionswww.outsourcefs.com

VECO USAwww.veco.com

CONSULTING AND SPECIALIZED SERVICESAffygility Solutionswww.affygility.com

BeamOnewww.beam-one.com

Biomed Inkwww.biomedink.com

BioPharma Training Institutewww.biopharmatraining.com

Bioscience Translation & Applicationwww.biotransapp.com

Capstonewww.capstone.com

Chart Biotech Consulting

Colorado Corn Growers Associationwww.coloradocorn.com

Embassy Suiteswww.eshgateway.com

Excel Biomedical Associateswww.excelbiomed.com

Front Range Technical Strategies

Med Quality Centralwww.medqualitycentral.com

Mid-Continent Technology Transfer Centerwww.mcttc.com

MPI Researchwww.mpiresearch.com

Onody Associateswww.onodyassoc.com

Peak to Peak Pharmaceutical Associates

PhRMAwww.phrma.org

Precision Management Consultantswww.precisionmanage.com

Publicis Selling Solutionswww.psellingsolutions.com

QuickSTATwww.qicstat.com

Reimbursement Principleswww.reimbursementprinciples.com

RenewalNetwww.renewalnet.com

Research Consultants

Resnik Partnerswww.resnikpartners.com

RMC Pharmaceutical Solutions

Robsun Consultingwww.robsuninc.com

Scientific Due Diligencewww.scientificduediligence.com

Strategy 3www.samsondesign.com

Strategic Computing

Summit Roundtablewww.summitroundtable.com

TransPerfect Translationwww.transperfect.com

Wild Rose Biophysics

ECONOMIC DEVELOPMENTAdams County Economic Developmentwww.adamscountyed.com

Aurora Economic Development Councilwww.auroraedc.com

British Consulate - Denverwww.britainusa.com

Canadian Consulatewww.international.gc.ca

City of Denverwww.denvergov.org

Colorado Office of Economic Developmentand International Tradewww.state.co.us/oed

Denver Metro Chamber of Commercewww.denverchamber.org

DIA Partnershipwww.diapartnership.org

Jefferson County Economic Councilwww.jeffco.org

JETRO Los Angeleswww.jetrolosangeles.org

Longmont Area Economic Councilwww.longmont.org

Metro Denver Economic DevelopmentCorporationwww.metrodenveredc.org

Northern Colorado Economic DevelopmentCorporationwww.ncedc.com

FINANCIAL AND INVESTMENTAweida Capital Managementwww.aweida.com

Boulder Ventureswww.boulderventures.com

Commerce Bankwww.commercebankcolorado.com

Ernst & Youngwww.ey.com

Merrill Lynch - Office of Bruce Williamswww.ml.com

Morgenthaler Ventureswww.morgenthaler.com

Pricewaterhouse Cooperswww.pwc.com

Quasar Groupwww.quasargroup.com

Quest Capital Partners

Sequel Venture Partnerswww.sequelvc.com

Silicon Valley Bankwww.svb.com

Tango

Tatum Partnerswww.tatumpartners.com

Trinity Capital Serviceswww.tricapllc.com

UV Partnerswww.uven.com

Wells Fargo Bankwww.wellsfargo.com

Bioscience Resources

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HUMAN RESOURCEADMINISTRATIONEmployer Services Groupwww.esgnet.com

TriNetwww.trinet.com

INSURANCEChubb Group of Insurance Companieswww.chubb.com

Colorado Insurance Professionalswww.colorado-insurance.com

Turnock Companies

Van Gilder Insurance Corporationwww.vgic.com

LABORATORY SUPPLIERSAirgaswww.airgas.com

Alphatekwww.alphatek-inc.com

Barrier Cleanwww.barrierclean.com

bioBubblewww.biobubble.com

Continental Lab Productswww.clpdirect.com

Extronexwww.extronex.com

Linweldwww.linweld.com

VWR Internationalwww.vwr.com

LEGAL SERVICESCooley Godwardwww.cooley.com

Dorsey & Whitneywww.dorsey.com

Faegre & Bensonwww.faegre.com

Fairfield and Woodswww.fwlaw.com

Hogan & Hartsonwww.hhlaw.com

Holland & Hartwww.hollandhart.com

Holme Roberts & Owenswww.hro.com

Merchant & Gouldwww.merchant-gould.com

Patton Boggswww.pattonboggs.com

Sheridan Rosswww.sheridanross.com

Snell & Wilmerwww.swlaw.com

Swanson & Bratschunwww.sbiplaw.com

Townsend and Townsend and Crewwww.townsend.com

MARKETING & PUBLICRELATIONSAbsolutely Public Relationswww.absolutelypr.com

Bawmann Groupwww.morethanpr.com

Bond Video Artswww.bondvideoarts.com

BoomCom Communicationswww.boomcom.com

Burns Marketing Communicationswww.burnsmarketing.com

Downs Marketing

Griff/SMC Marketing Communicationswww.griffsmc.com

ISIS Public Relations & Marketingwww.isispr.com

Joe Knowswww.joe-knows.com

Paul L. Anderson Productionswww.paulanderson.com

Sage Public Relations Groupwww.sagepublicrelations.com

Visible Productionswww.visibleproductions.com

Visual Sciencewww.visualsci.com

REAL ESTATEStaubachwww.staubach.com

RECRUITING & PLACEMENT

Cassie Shipherd Groupwww.cassie.com

DHR Internationalwww.dhrintl.net

B i o s c i e n c e C O L O R A D O

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Emerging Medical Technologies

Kelly Scientificwww.kellyservices.com

Kforce Scientificwww.kforce.com

Management Recruiters of Denver Southwww.mridenversouth.com

On Assignmentwww.labsupport.com

Scientempswww.scientemps.com

Volt Scientific Serviceswww.Volt.com

REGULATORY CONSULTINGCBR Internationalwww.cbrintl.com

Cericonwww.cericon.com

International Approvals Laboratorieswww.ialabs.com

Medical Device Consultantswww.mdci.com

M.W. Wenzel Consultingwww.home.earthlink.net

PharmaSyswww.pharma-sys.com

Reglera Corporationwww.reglera.com

RESEARCH & OFFICE PARKSFitzsimons Redevelopment Authoritywww.colobio.com

Forest City Stapletonwww.StapletonDenver.com

Fort Collins Technology Incubatorwww.fortcollinsincubator.org

Pratt Managementwww.prattland.com

Westfield Development/Frederick Rosswww.frederickross.com

TECHNOLOGYCaleriswww.caleris.com

Covansyswww.covansys.com

IBM Corporationwww.ibm.com/businesscenter/lifesciences