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TACTIC Trans-Agency Consortium for the Analysis and Characterization of Trauma Induced Coagulopathy Philadelphia Sept 10 2014

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COAGULOPATHY Consumptive Dilutional Acidosis Hypothermia Inflammation/Vascular Cell Mediated

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COAGULOPATHY Trauma Induced Therapy Induced

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PREAMBLE To study the natural history of the coagulation proteome in trauma it is abundantly clear that the environment associated with sample acquisition in trauma is totally different than that observed in conventional clinical trials.

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TACTIC PROJECTS

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CLINICAL CENTERS Systems Biology Fredrick, MD San Francisco, CA Washington, DC Burlington, VT University of Colorado Denver Health University of Colorado Denver Bonfils Blood Center University of Pittsburgh Case Western Reserve Metrohealth Medical Cleveland, OH Vanderbilt University of Tennessee, Knoxville University of Texas Southwestern, Parkland University of Louisville Virginia Commonwealth University Henrico County Fire and Rescue Richmond Ambulance Authority Virginia Blood Services

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RESEARCH THEMES Thrombin Generation in Trauma-Induced Coagulopathy Platelet Function in Trauma-Induced Coagulopathy Vascular Function in Trauma-Induced Coagulopathy Analysis of Coagulopathy in Trauma Blood Cell and Blood Cell Products in Trauma-Associated Inflammation Endothelial Injury in Trauma-Associated Inflammation

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Steering Committee Project Director/Executive Committee TACTIC Administration Department of Defense Clinical Centers Coord. Center Repository Coagulation Research Inflammation Research Early Translational Applications Group

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