T H O M S O N S C I E N T I F I C Bonnie Snow Research Director, Clinical Content & Applications...

T H O M S O N S C I E N T I F I C

Bonnie SnowResearch Director, Clinical Content & Applications

What’s New: Sept 2007 – March 2008

SLA Pharmaceutical & Health Technology DivisionSpring Meeting, April 2008, St. Petersburg, FL

Copyright 2008 Thomson Corporation 2


Thomson Pharma® Content

• Drugs - more than 28,000 (approx. 150 added each month)

• Companies - 7,500 (includes other organizations involved in drug development, e.g., academic, government)

• Meetings – 400 meetings/year, information from key conferences published overnight

• Patents - information from 41 patent-issuing authorities

• Journals – information from more than 11,000 peer-reviewed journals

• Compounds – more than 3 million (approx. 5,000 added each month)

• Sequences – more than 8 million (approx. 16,000 - 20,000 added each month)

• Targets – 5,200+



Content is delivered in structured, cumulative reports



Content



Specialty Current Awareness Home Pages

• Biology

• Chemistry

• Clinical Pipeline

• Clinical Trials

• Licensing & Business Development

• Competitive Intelligence

• News & Meetings

• Intellectual Property

• Regulatory Affairs

• Brand Management

• Generic Competition

• Create your own……



Each Subject or Specialty homepage provides a selection of current awareness portlets.



What’s New?

• Detailed information on DEALS in Thomson Pharma– A “Deal” is a collaborative or licensing agreement between two

companies

• Thomson Pharma Drug & Company Reports already incorporate textual summaries of licensing agreements

– Reports now include links to Deal Reports for additional information about each agreement

• Enhanced coverage introduced in September 2007– Separate reports on each Deal, with detailed financial data and event

history• Highly structured, “fielded” data provides advanced search

capabilities– Two new current awareness portlets, filterable by therapy area



Two new current awareness portlets introduced on the Licensing & Business homepage



Users can add these portlets to their personal homepages, along with other preferred selections from a menu of 25 current awareness portlets now available in Thomson Pharma®



Search Form [continued]:

Additional DEAL filtering options



DEAL FINDER capability added to Guided Search options



What’s New?

• New Specialty section devoted to Clinical Trials

• Two new types of reports added to Thomson Pharma– Structured summaries of trial Protocols and Outcomes

• Determine status & progress of clinical research not just at the drug and company level, but also at the specific study level: e.g., number of studies, size and scope, expected duration

• Compare outcomes measures used, drugs identified as active controls, randomization and masking, patient eligibility parameters

• Adapt trial design & development program to address emerging competitive issues & ensure that evidence obtained from studies is not only adequate for product approval, but also for effective product positioning & rapid adoption, once launched

• Site and clinical investigator selection• Identifying trends and benchmarking



What’s New?

• New Specialty section devoted to Clinical Trials

• Two new types of reports added to Thomson Pharma– Structured summaries of trial Protocols and Outcomes – Linked to relevant Drug and Company Reports in Thomson

Pharma

• New current awareness portlets to assist in monitoring trial developments

• Sources: company websites, press releases, conferences, journals, protocol registries, including Clinical Trials.gov, ISRCTN register, WHO ICTRP portal (China, India, Australia/NZ), Japan, IFPMA portal



New Specialty Section & Current Awareness Portlets



Adjust time period & units (weeks/months) depicted in

display

Change to tabular summary, if desired

Hovering over a given data point

invokes display of further details



Protocol Trends portlet – User interaction with graph affects content of histograms

Clicking on data elements in histograms leads directly to designated protocols



Direct link to associated Outcomes Report, when available



Sponsors & Collaborators: Standardized T-Pharma organization names

Added organization classification: Industrial, Academic, Government



Study Phase terms:

Not specified

Phase 0

Phase 1

Phase 1/Phase 2

Phase 2

Phase 2a

Phase 2b

Phase 2/Phase 3

Phase 3

Phase 3b

Phase 4

Enhance minimum standards set by FDA & WHO with additional controlled vocabulary/thesaurus terms



• INTERVENTIONS– Name [standardized T-Pharma drug name + synonyms]– Role (Primary Intervention, Active Control—coordinated

with named compounds)

Intervention Types:

Drug

Gene Transfer

Vaccine

Device

Procedure

Behavior

Drug Combination

Cell Therapy



Basic data provided by study sponsor enhanced with Thomson Pharma value-added indexing

• Conditions (sponsor’s keywords + T-Pharma Indication, Therapeutic category, Action terms)


T H O M S O N S C I E N T I F I CData Elements in RED = Value-Added Indexing

Point & click search routines developed to retrieve related protocol records

Associated Biomarkers

Type:

Discovery/validation of disease markers

Discovery of therapeutic effect markers

Measurement of therapeutic effect markers



Adding controlled “Ethnicity” terms, when applicable + MeSH age groups



Adding standardized TPharma organization names + controlled country names + regional classification



Links to Thomson Pharma Drug & Company Reports + full text of primary source



An entirely new set of index terms was created to facilitate searches on treatment details. Users will be able to view menus of predictable vocabulary for “units of measure’ when searching on dose levels or duration of regimen, plus standardized terms for route & frequency of administration.



Value-add: Tabular summaries of adverse event data + controlled (predictable) vocabulary for events, including AE Category terms



Outcomes Reports integrate & accumulate data derived from

multiple sources.



Option to search specific factors in treatment regimens



• Clinical Trial Section Scope – 7.3 Release (Sept 2007 - )

• Protocols & Associated Outcomes Reports for:

– Three indications (specific conditions)

• Alzheimer’s• Rheumatoid Arthritis• Diabetes (and its

complications)– All three offered as part of basic

Thomson Pharma subscription– More than 2,200 reports provided

as a working example of the depth & quality of indexing + powerful search capabilities

• In 2008, extending scope to include coverage of all therapeutic areas currently covered in the Thomson Pharma investigational drug database.

• Segments for each additional therapeutic area (consisting of both Protocols and Outcomes Reports for all related indications) will be released in a succession of optional add-ons to basic subscription throughout 2008, as indexing in each therapeutic area is completed.

– Cardiovascular – March

– Neurological – May

– Infection – June

– Gastrointestinal – August

– Immune Disorders - Sept



What’s New?

• Smart Alerts

• Designed to capture new associations that would be very difficult to find using standard search techniques

– First product patent filed by a company on a new target

– First time link of a target with a therapy area on a patent

– First third-party patent on any drug

– First occurrence of an action term in a patent

– First patent filing for a company

– First time joint patent filings between two organizations

– First time occurrence of an action term on a drug

– New chemical structures that have been added to drug reports



How is the Information Displayed?

HOMEPAGE: Competitive Intelligence

New Portlet: Smart Alerts– Filterable by Therapy Area

– Set up email alerts



Filter the information by therapy area, patent owner

etc. to produce a more refined results list



What’s New? Entelos Reports

• Entelos Inc., the leader in predictive biosimulation, develops computer models of human physiology and creates “virtual patients” to optimize pharmaceutical and biotechnology research and development.

• PhysioLab ® technology is used to test novel interventions, predict efficacy, assess safety, optimize product development, and better position existing products in competitive markets.

• Entelos Reports provide unique predictive content about a specific biological target.

• Access Entelos reports from a hot-linked logo on the Thomson Pharma homepage or from the ‘Browse Targets’ menu

• Three types of report will be available– Target, Clinical, and Commercial



Overview of the 8.1 release (March 2008)

Latest enhancements to Thomson Pharma focus on visualization tools for analysis and streamlined navigation

• Improved charting/‘Rank by’ options• Bar charts• Pie charts• Matrices

• Star Tree/Hyperbolic Tree visualizations

• Metadata Fingerprints

• PLUS another option for current awareness: RSS Feeds



Rank by – Bar Charts

• New format bar charts– Interactive: click on a

chart segment to view corresponding results

– More ‘Rank by’ options, including parent company, originator

– Ability to select up to 70 top ranking items per chart

– Specify parameters and chose cut-off limits

– Option to select a subset of results to drill down and analyze further

Benefit: Enables quick detection of patterns within your results and jump to specific subsets identified through ranking



Rank by – Pie Charts

• Additional visualization option– Interactive chart, click on a

segment of the pie to view those specific results

– Uses same ‘Rank by’ options as the bar charts

– Ability to chart up to 20 top-ranking items within the data element designated for analysis

– Option to select a subset of results to drill down and analyze further

Double click on a segment of the pie chart to isolate a

specific subset within your search results

Hover over a segment to see more details



Rank by – Matrix Display

• Two-dimensional matrices show relationships within results

– Analyse two fields (e.g. action vs. therapy area) at a glance to detect patterns & trends

– Interactive chart: click on any number to view those specific records

– Color codes: the darker the color, the larger the number of corresponding results

– Option to select a subset of results to drill down and analyse further



Star Trees

• Hyperbolic Trees (Star Trees) – Give you the ability to explore

and analyse drug and patent results lists in a new visual form

– Allow users to navigate and explore hierarchical relationships and drill-down to information of interest

– Fully interactive charts• Colour coded• Movable, can re-centre

around a different point of interest

– 2 predefined options or The displayed can be moved around to view the chart from

different angles

Change the display options e.g. colour coding, format

Benefit: Allows users to navigate and explore hierarchical relationships and drill-down to information of interest



Metadata Fingerprints

• Show the content associated with each report

• Enable you to filter your results by report attributes

– Click on a segment to narrow down your results to items containing the selected attribute

– Advanced filtering options enable you to exclude, as well as include, designated information in your results list

Benefit: Makes it easy for users to determine which reports are of most interest, without having to open them



RSS Feeds

• Set up RSS feeds out of Thomson Pharma from 8 of the homepage portlets e.g. meetings

– Recommended to use either Internet Explorer 7 or Firefox 2

Benefit: Content of Thomson Pharma current awareness portlets can be displayed alongside other news feeds of interest to users



System Requirements

• In order to benefit from the latest enhancements to Thomson Pharma, and to continue using the ‘rank by’ function, users must have the following plug-ins installed on their pcs

– Java version 1.4 or above http://wwww.java.com

– Adobe Flash Player 9 or above http://www/adobe.com/products/flashplayer

• These plug-ins are free to download

• If you do not have the correct plug-in a message will be displayed alerting you to the fact

T H O M S O N S C I E N T I F I C Bonnie Snow Research Director, Clinical Content & Applications...

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