Systematic reviews of critical values in key laboratory analytes: … · 2019-06-21 · Professor...
Transcript of Systematic reviews of critical values in key laboratory analytes: … · 2019-06-21 · Professor...
AUSTRALIAN INSTITUTE OF HEALTH INNOVATION Faculty of Medicine and Health Sciences
Systematic reviews of critical values in key laboratory analytes: Program handbook
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PROGRAM TEAM
Dr Que Lam, AACB-RCPA High Risk Results Working Party
Professor Andrea Rita Horvath, AACB-RCPA High Risk Results Working Party
Professor Andrew Georgiou, Macquarie University
Dr Rae-Anne Hardie, Macquarie University
Ms Julie Li, Macquarie University
Program material prepared and presented by:
Centre for Health Systems and Safety Research Australian Institute of Health Innovation, Faculty of Medicine and Health Sciences Macquarie University, Sydney, Australia June 2019
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TABLE OF CONTENTS
Program Team ..........................................................................................................................2 Background ..............................................................................................................................4 Course contacts ........................................................................................................................4 Program schedule..................................................................................................................... 5 Training program design ........................................................................................................ 6 On-campus workshop schedule ............................................................................................... 7 Module 1: Developing the research question ......................................................................... 8 Module 2: Synthesis of the search strategy ............................................................................ 8 Module 3: Screening the literature ......................................................................................... 9 Module 4: Data extraction and ............................................................................................... 9 Module 5: Quality assessment (and data ranking) ................................................................. 9 Module 6: Report writing and presentation to AACB ........................................................... 10 Optional Modules for future opportunity .............................................................................. 10 Module 7: Write up ................................................................................................................ 10 Resources ............................................................................................................................... 11
Systematic reviews of critical values in key laboratory analytes: Program handbook
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BACKGROUND Critical risk results are laboratory results requiring immediate medical attention and action because they indicate a high risk of imminent death or patient harm. The Australasian Association of Clinical Biochemists (AACB)-Royal College of Pathologists of Australasia (RCPA) High Risk Results Working Party aims to publish a list of evidence-based high risk result thresholds for the purpose of harmonising laboratory practices. The work undertaken by participants in the program will contribute to this goal. Successful applicants are supported by scholarships awarded by AACB and RCPA.
This program is offered in conjunction with Macquarie University as part of an NHMRC Partnership project (1111925) with NSW Health Pathology and the Australian Commission on Safety and Quality in Health Care entitled “Delivering safe and effective test-result communication, management and follow-up.”
COURSE CONTACTS
Dr Rae-Anne Hardie
Postdoctoral Research Fellow
Email: [email protected]
Ms Julie Li
Research Assistant
Email: [email protected]
Dr Que Lam
AACB-RCPA High Risk Results Working Party
Email: [email protected]
Systematic reviews of critical values in key laboratory analytes: Program handbook
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PROGRAM SCHEDULE
Date Modules and deliverables
14 June 2019 Macquarie University Workshop
Weeks 1-2 (17-28 June)
Module 1: Developing the research question
Weeks 3-4 (1-12 July)
Module 2: Synthesis of the search strategy
Week 4 (8-12 July)
Deliverable 1: Submit (a) A search strategy containing keywords and subject headings for each database including inbuilt filters; (b) PROSPERO registration summary before submitting
Weeks 5-10 (15 July-23 August)
Module 3: Screening the literature
Week 6 (22-26 July)
Zoom meeting: Endnote skills workshop
Week 8 (5-9 August)
Zoom meeting: Literature screening Q & A
Week 10
(19-23 August) Deliverable 2: Submit an Endnote library containing all final papers and PRISMA flowchart
Weeks 11-14 (26 August-20 September)
Module 4: Data extraction
Module 5: Quality assessment
Week 11 (26-30 August)
Zoom meeting: Quality assessment workshop
Week 13 (9-13 August)
Zoom meeting: Final data extraction and write up Q & A
Week 15-16 (23 September-4 October)
Module 6: Report writing and presentation to AACB
Week 16 (30 September-4 October)
Deliverable 3 (week 16): Submit report containing (a) 1-page referenced background of the test and its impact on outcomes; (b) Standardised results table; (c) Quality assessment of the level of the underlying evidence
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TRAINING PROGRAM DESIGN Full-day on-campus workshop covering:
• Introduction to systematic reviews/PROSPERO registration
• Developing a research question, inclusion/exclusion criteria
• Search strategies and key word/headings
• Database searching
• Using Endnote
• How to perform literature screening
• Data extraction and quality assessment
Modules and videoconference workshops: • Conducted over 16 weeks following the on-campus workshop
• Participants will work in teams of 2-3 per analyte
• Analytes will be assigned by the AACB-RCPA/MQ team with all efforts to match participant preference
• MQ will conduct follow-up sessions with each group to ensure projects are tracking well, and provide formal checks and feedback on deliverables
Minimum expectations: • It is expected that participants will be able to dedicate 1-2 full days per week for the
duration of the program and are expected to attend the full-day on-campus workshop and follow-up meetings. Based on this time commitment, the review should be feasible to complete within 16 weeks if all deliverables are completed on schedule
• Deliverables as detailed in this handbook
• Participants will provide AACB-RCPA High Risk Results Working Party with a brief background on the test and what is considered a critical outcome, alert table of results, level of evidence, and quality assessment
On completion, future opportunities to present, publish, or undertake further training may be possible
Systematic reviews of critical values in key laboratory analytes: Program handbook
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ON-CAMPUS WORKSHOP SCHEDULE Friday, 14th June, 2019 Macquarie University, Level 6, 75 Talavera Road, Macquarie Park
9:30 Morning Tea
10:00 Welcome to Country and introductions Prof Andrew Georgiou
10:15 Introduction to the program Dr Que Lam
10:25 High-level overview of expected commitment for participants to complete the program
Prof Andrew Georgiou
10:30 Housekeeping items: email, library login Dr Rae-Anne Hardie/Julie Li
10:45 Introduction to Evidence-based Laboratory Medicine/PRISMA/PROSPERO registration
Dr Rae-Anne Hardie/Julie Li
11:30 Developing a research question, inclusion/exclusion criteria
Dr Rae-Anne Hardie/Julie Li
12:15 Lunch
13:15 Database searching: search strategies and keywords/headings
Library team (Jane Van Balen and Jeremy Cullis)
14:15 Exporting your papers and using EndNote
Library team (Jane Van Balen and Jeremy Cullis)
15:00 Break
15:15 How to perform literature screening Julie Li/Dr Rae-Anne Hardie
15:45 Data extraction and quality assessment Craig Campbell
16:00 A case study using calcium Wilson Punyalack
16:30 Questions Review Program Handbook & dates
Dr Rae-Anne Hardie/Julie Li
16:45 Closing remarks Dr Que Lam/Prof Andrew Georgiou
17:00 Workshop close
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MODULE 1: DEVELOPING THE RESEARCH QUESTION
LEARNING OBJECTIVES: 1. Learn to formulate the research question using the PICO (Problem/Patient/Population,
Intervention/Indicator, Comparison, Outcome) framework 2. How to perform an initial hand search and landscape overview of literature 3. How to identify key papers and any related systematic reviews covering the same research
question 4. Learn to develop inclusion and exclusion criteria
MODULE 2: SYNTHESIS OF THE SEARCH STRATEGY
LEARNING OBJECTIVES: 1. Learn how each search database search tool works (e.g. Medline, PubMed, Scopus, EMBASE) 2. Learn how to use key search terms (e.g. MeSH, subject headings, key words) 3. Learn how to enter search shortcuts 4. Learn how to perform and optimise a search strategy that will yield the optimal number of
papers 5. Learn how to filter for date range, language, article type, population, etc. 6. Learn how to save and export searches into EndNote 7. Learn how to document the review steps using PRISMA principles 8. How to register the study in PROSPERO (International prospective register of systematic
reviews)
Deliverable 1 (week 4): Submit (a) A search strategy containing keywords and subject headings for each database including inbuilt filters; (b) PROSPERO registration summary before submitting
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MODULE 3: SCREENING THE LITERATURE
LEARNING OBJECTIVES: 1. Learn to perform title and abstract screening and evaluation in EndNote 2. Learn how to use Covidence website to perform full text review and screening using pre-set
exclusion criteria 3. Learn how to undertake a decision-making consensus process 4. Learn how to create a new EndNote library containing only the final papers agreed upon after
screening
Deliverable 2 (week 10): Submit an Endnote library containing all final papers and PRISMA flowchart
MODULE 4: DATA EXTRACTION AND
MODULE 5: QUALITY ASSESSMENT (AND DATA RANKING)
LEARNING OBJECTIVES: 1. How to create a data extraction table or database using evidence from each paper to answer
the research question 2. Learn how to perform a quality assessment of each paper and the data using the appropriate
tool. Each paper will be scored using an appraisal tool based on the JAMA users’ guide1 for an article about harm
1 Levine M, Walter S, Lee H, Haines T, Holbrook A, Moyer V. Users' guides to the medical literature. IV. How to use an article about harm. Evidence-Based Medicine Working Group. JAMA. 1994;271(20):1615-9.
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MODULE 6: REPORT WRITING AND PRESENTATION TO AACB
LEARNING OBJECTIVES: 1. Learn to perform the appropriate statistics on the extracted data 2. Learn to write up and present the results to RCPA-AACB High Risk Results Working Party
Deliverable 3 (week 16): Submit report containing (a) 1-page referenced background of the test and its impact on outcomes; (b) Standardised results table; (c) Quality assessment of the level of the underlying evidence
OPTIONAL MODULES FOR FUTURE OPPORTUNITY
MODULE 7: WRITE UP
LEARNING OBJECTIVES: 1. How to incorporate Working Party feedback 2. How to write up the literature review as a manuscript/systematic review 3. How to present review at conference 4. How to pursue potential further training opportunities, MRes, PhD
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RESOURCES Throughout the Program, additional Resources will be uploaded here.
Endnote download https://tinyurl.com/endnoteMQ
Macquarie University Library https://tinyurl.com/libraryMQ
Cochrane Library website https://tinyurl.com/cochraneMQ
Covidence website for full text screening https://tinyurl.com/covidence
PICO – a useful tool for asking focused clinical questions https://tinyurl.com/PICOMQ
PRISMA - Preferred Reporting Items for Systematic Reviews and Meta-Analyses
https://tinyurl.com/PRISMAMQ
PROSPERO website for registering review https://tinyurl.com/PROSPEROMQ
Campbell CA, Georgiou A, Westbrook JI, Horvath AR. What alert thresholds should be used to identify critical risk results: A systematic review of the evidence. Clinical Chemistry. 2016; 62(11):1445-57.
https://tinyurl.com/alertthresholds
Campbell CA, Lam Q, Horvath AR. An evidence- and risk-based approach to a harmonized laboratory alert list in Australia and New Zealand. Clinical Chemistry and Laboratory Medicine (CCLM). 2018; 57(1): 89-94.
https://tinyurl.com/harmonizedCCLM
Georgiou A. Finding, appraising and interpreting the evidence of health IT. In: Ammenwerth E, Rigby M, editors. Evidence-Based Health Informatics. Amsterdam: IOS Press; 2016. p. 312-23.
https://tinyurl.com/evidencehealthIT
Horvath AR, Pewsner D. Systematic reviews in laboratory medicine: principles, processes and practical considerations. Clinica Chimica Acta. 2004; 342(1):23-39.
https://tinyurl.com/SRlabmed
Levine M, Walter S, Lee H, Haines T, Holbrook A, Moyer V. Users' guides to the medical literature. IV. How to use an article about harm. Evidence-Based Medicine Working Group. JAMA. 1994;271(20):1615-9.
https://tinyurl.com/levineJAMA
Punyalack W, Hardie R-A, Li L, Li J, Campbell C, Badrick T, Georgiou A. High risk results – the evidence for total serum calcium alert thresholds. Pathology. 2019; 51:S18.
https://tinyurl.com/highriskresults
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