Systematic reviewing oct2011
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CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
Systematic Literature Reviews:A 'How To' Guide
Isla Kuhn
Reader Services Librarian
Medical Library
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
• how to clarify the question(s)
• selecting the databases and other resources to search
• devising the most comprehensive literature search strategy so you know you’ve not missed any relevant studies
• keeping up to date with new information appearing between the initial search and write-up
• issues around documentation of process and results
• management of references, and getting hold of the full text article
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
1 clinical trial.pt.2 randomized.ab,ti.3 placebo.ab,ti.4 dt.fs.5 randomly.ab,ti.6 trial.ab,ti.7 groups.ab,ti.8 or/1-79 Animals/10 Humans/11 9 not (9 and 10)12 8 not 1113 dorsalgia.ab,ti.14 exp Back Pain/15 exp Low Back Pain/16 backache.ab,ti.17 (lumbar adj pain).ab,ti.18 coccyx.ab,ti.19 coccydynia.ab,ti.20 exp Sciatica/21 sciatica.ab,ti.22 spondylosis.ab,ti.23 lumbago.ab,ti.
24 or/13-2325 exp Spine/26 discitis.ab,ti.27 exp Spinal Diseases/28 (disc adj degeneration).ab,ti.29 (disc adj prolapse).ab,ti.30 (disc adj herniation).ab,ti.31 spinal fusion.sh.32 spinal neoplasms.sh.33 (facet adj joints).ab,ti.34 intervertebral disk.sh.35 postlaminectomy.ab,ti.36 arachnoiditis.ab,ti.37 (failed adj back).ab,ti.38 or/25-3739 exp activities of daily living/40 activities of daily living.tw.41 day to day activ$.ti,ab.42 daily activit$.ti,ab.43 ordinary activit$.ti,ab.44 normal activit$.ti,ab.45 stay$ active.ti,ab.
46 exp Bed Rest/47 bed rest.mp.48 or/39-4749 24 or 3850 12 and 4951 48 and 50
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYFrom topic to search
introducing the research topic
• clarifying the question
• setting parameters (inclusion/exclusion criteria not built into search?)
lose marks through sloppy referencesQuestionKeywordsSynonyms MeSH / sub headingsBoolean LogicTruncation / wildcardsLimits
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYFrom topic to search
• Topic -> question -> keywords/synonyms
Diabetes, especially the impact of patient education …..
”Is patient education effecting in improving blood sugar control in teenage diabetics?”
…………………keywords???.... synonyms???........................Themes?
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
”Is patient education effecting in improving blood sugar control in teenage diabetics?”
1 – teenagers
2 – patient education
3 – blood sugar
From topic to search
Synonyms?
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
”Is patient education effecting in improving blood sugar control in teenage diabetics?”
1 – teenagers teens adolescents
2– patient education patient information
3 – blood sugar blood glucose hypoglycaemia hyperglycaemia
From topic to search
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYBoolean Logic
AND – to narrow the search by combining different topics
eg
“physiotherapy” and “stroke”
Both terms must be present in the results.
StrokePhysiotherapy
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYBoolean Logic
OR – to broaden your search, by combining similar terms
eg
“exercise” or “physical activity”
Either term can be present in the resulting set of articles.
Cerebral-vascular Accident
Stroke
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYBoolean Logic
NOT – to restrict your search so that it does not contain a particular term
eg
“physical therapy” not “manual therapy”
The first, but not the second, term must be present.
Manual Therapy
Physical Therapy
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
”Is patient education effecting in improving blood sugar control in teenage diabetics?”
1 – teenagers OR teens OR adolescents
AND
2 – patient education OR patient information
AND
3 – blood sugar OR blood glucose OR hypoglycaemia OR hyperglycaemia
From topic to search
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYQuestion:
1st theme OR OR OR
AND
2nd theme OR OR OR
AND
3rd theme OR OR OR
AND
4th theme? OR OR OR
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYTruncation
treat
treats
treating
treated
treater
treatment
treatments
• Treat*
• Treat?
• Treat$
Treatment
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
Truncation / wildcards?
1 – teenagers OR teens OR adolescents
AND
2 – patient education OR patient information
AND
3 – blood sugar OR blood glucose OR hypoglycaemia OR hyperglycaemia
From topic to search
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
Truncation / wildcards?
1 – teen* OR adolesce*
AND
2 – patient education OR patient information
AND
3 – blood sugar OR blood glucose OR hypoglyc* OR hyperglyc*
From topic to search
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYTask
• Go to http://wok.mimas.ac.uk
• Open Web of Science
• Type a key word, and search by “topic”
• How many hits?
• Type the keyword with some truncation (use *)
• How many hits?
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYFrom topic to search
• Where in the article record do you want the terms/keywords to appear?
• Title?
• Abstract?
• All/any field?
• Impact on sensitivity/specificity?
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYTask
• Go to http://wok.mimas.ac.uk
• Open Web of Science
• Type a key word, and search by “topic”
• How many hits?
• Type a keyword and search by “title”
• How many hits?
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
MeSH
“MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.”
From topic to search
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
http://www.ncbi.nlm.nih.gov/pubmed/20440928
MeSH
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
MeSH
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
http://www.ncbi.nlm.nih.gov/mesh/68007003
MeSH & Subheadings
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
http://www.ncbi.nlm.nih.gov/mesh?term=epidemiology
MeSH & Subheadings
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
MeSH
1 – teen* OR adolesce* OR "Adolescent"[Mesh]
AND
2 – patient education OR patient information OR "Patient Education as Topic"[Mesh]
AND
3 – blood sugar OR blood glucose OR hypoglyc* OR hyperglyc* OR "Blood Glucose"[Mesh] OR "Hypoglycemia"[Mesh]
From topic to search
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
Limits?
teen* OR adolesce* OR "Adolescent"[Mesh]
AND
patient education OR patient information OR "Patient Education as Topic"[Mesh]
AND
blood sugar OR blood glucose OR hypoglycae* OR hyperglyca* OR "Blood Glucose"[Mesh] OR "Hypoglycemia"[Mesh]
From topic to search
Year of publication? Humans vs Animals? Type of publication? Language of publication?
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
From topic to search: same strategy, different words
Moving from one database to another…..
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
From topic to search: same strategy, different words
• http://www.sign.ac.uk/methodology/filters.html Observational Study Filters
Medline (via OVID)1 Epidemiologic studies/ 2 Exp case control studies/ 3 Exp cohort studies/ 4 Case control.tw. 5 (cohort adj (study or studies)).tw. 6 Cohort analy$.tw. 7 (Follow up adj (study or studies)).tw. 8 (observational adj (study or studies)).tw. 9 Longitudinal.tw. 10 Retrospective.tw. 11 Cross sectional.tw. 12 Cross-sectional studies/ 13 Or/1-12
Embase (via OVID)1 Clinical study/ 2 Case control study 3 Family study/ 4 Longitudinal study/ 5 Retrospective study/ 6 Prospective study/ 7 Randomized controlled trials/ 8 6 not 7 9 Cohort analysis/ 10 (Cohort adj (study or studies)).mp. 11 (Case control adj (study or studies)).tw. 12 (follow up adj (study or studies)).tw. 13 (observational adj (study or studies)).tw. 14 (epidemiologic$ adj (study or studies)).tw. 15 (cross sectional adj (study or studies)).tw. 16 Or/1-5,8-15
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
From topic to search: same strategy, different words
• http://www.sign.ac.uk/methodology/filters.html Observational Study Filters
Medline (via OVID)1 Epidemiologic studies/ 2 Exp case control studies/ 3 Exp cohort studies/ 4 Case control.tw. 5 (cohort adj (study or studies)).tw. 6 Cohort analy$.tw. 7 (Follow up adj (study or studies)).tw. 8 (observational adj (study or studies)).tw. 9 Longitudinal.tw. 10 Retrospective.tw. 11 Cross sectional.tw. 12 Cross-sectional studies/ 13 Or/1-12
Medline (via Pubmed)#1 “Epidemiologic studies”[Mesh]#2 “case control studies”[Mesh]#3 “cohort studies”[Mesh]#4 Case control[Text Word] #5 (cohort stud*))[Text Word] #6 Cohort analy*[Text Word]#7 (Follow up AND (study or studies))[Text Word] #8 (observational AND (study or studies))[Text Word]#9 Longitudinal[Text Word]#10 Retrospective[Text Word]#11 Cross sectional[Text Word]#12 “Cross-sectional studies”[Mesh]#13 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
1 clinical trial.pt.2 randomized.ab,ti.3 placebo.ab,ti.4 dt.fs.5 randomly.ab,ti.6 trial.ab,ti.7 groups.ab,ti.8 or/1-79 Animals/10 Humans/11 9 not (9 and 10)12 8 not 1113 dorsalgia.ab,ti.14 exp Back Pain/15 exp Low Back Pain/16 backache.ab,ti.17 (lumbar adj pain).ab,ti.18 coccyx.ab,ti.19 coccydynia.ab,ti.20 exp Sciatica/21 sciatica.ab,ti.22 spondylosis.ab,ti.23 lumbago.ab,ti.
24 or/13-2325 exp Spine/26 discitis.ab,ti.27 exp Spinal Diseases/28 (disc adj degeneration).ab,ti.29 (disc adj prolapse).ab,ti.30 (disc adj herniation).ab,ti.31 spinal fusion.sh.32 spinal neoplasms.sh.33 (facet adj joints).ab,ti.34 intervertebral disk.sh.35 postlaminectomy.ab,ti.36 arachnoiditis.ab,ti.37 (failed adj back).ab,ti.38 or/25-3739 exp activities of daily living/40 activities of daily living.tw.41 day to day activ$.ti,ab.42 daily activit$.ti,ab.43 ordinary activit$.ti,ab.44 normal activit$.ti,ab.45 stay$ active.ti,ab.
46 exp Bed Rest/47 bed rest.mp.48 or/39-4749 24 or 3850 12 and 4951 48 and 50
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
1 clinical trial.pt.2 randomized.ab,ti.3 placebo.ab,ti.4 dt.fs.5 randomly.ab,ti.6 trial.ab,ti.7 groups.ab,ti.8 or/1-79 Animals/10 Humans/11 9 not (9 and 10)12 8 not 1113 dorsalgia.ab,ti.14 exp Back Pain/15 exp Low Back Pain/16 backache.ab,ti.17 (lumbar adj pain).ab,ti.18 coccyx.ab,ti.19 coccydynia.ab,ti.20 exp Sciatica/21 sciatica.ab,ti.22 spondylosis.ab,ti.23 lumbago.ab,ti.
24 or/13-2325 exp Spine/26 discitis.ab,ti.27 exp Spinal Diseases/28 (disc adj degeneration).ab,ti.29 (disc adj prolapse).ab,ti.30 (disc adj herniation).ab,ti.31 spinal fusion.sh.32 spinal neoplasms.sh.33 (facet adj joints).ab,ti.34 intervertebral disk.sh.35 postlaminectomy.ab,ti.36 arachnoiditis.ab,ti.37 (failed adj back).ab,ti.38 or/25-3739 exp activities of daily living/40 activities of daily living.tw.41 day to day activ$.ti,ab.42 daily activit$.ti,ab.43 ordinary activit$.ti,ab.44 normal activit$.ti,ab.45 stay$ active.ti,ab.
46 exp Bed Rest/47 bed rest.mp.48 or/39-4749 24 or 3850 12 and 4951 48 and 50
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
Advice to rest in bed versus advice to stay active for acutelow-back pain and sciatica
The objective of this review is to determine the effects of advice to rest in bed or stay active for patients with acute low-back pain or sciatica.
The following comparisons will be made:
• Bed rest versus staying active
• Bed rest versus other treatments (besides staying active)
• Shorter periods of bed rest versus longer periods of bed rest
• Staying active versus other treatments (besides bed rest)
• Comparison between different forms of advice to stay active (e.g. avoiding bedrest, staying active)
http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD007612/pdf_fs.html
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYKeywords
introducing the research topic
reviewing relevant literature
• identifying keywords and synonyms and MeSH
• structuring your search strategy with boolean logic
References
• DON’T plagiarise!
• Don’t lose marks through sloppy references
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYSensitivity vs Specificity
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYSensitivity vs Specificity
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYSensitivity vs Specificity
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
introducing the research topic
reviewing relevant literature
Identify relevant sources (and then search them!)
databases?
websites?
hand searching?
snowballing?
books?
grey literature?
ongoing trials?
• http://www.lib.cam.ac.uk/electronicresources/
• Google? Search by Organisation
• Which journals are key to your work?
• WoK or Scopus
• LibrarySearch or COPAC or GoogleBooks
• Google: blog search; SIGLE; conference proceedings
• Trials registers
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
introducing the research topic
reviewing relevant literature
Identify relevant sources (and then search them!)
References & PDFs
• Critically appraising
• managing refs & pdfs
• de-duplicating
• storing & accessing
• using them (cite while you write)
CASP http://www.casp-uk.net
“How to read a paper” Trish Greenhalgh WB 18.343 – in the Medical Library or http://tinyurl.com/bmj-trish
ZoteroMendeleyEndnoteWebEndnoteReference ManagerRefWorksPapers
Pdf xchange
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
introducing the research topic
reviewing relevant literature
Identify relevant sources (and then search them!)
References
Keeping up to Date
• alerts
• journal TOCs
• citation tracking
Email alertsRSS fees
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
introducing the research topic
reviewing relevant literature
Identify relevant sources (and then search them!)
References
Keeping up to Date
Writing Up
• what did you actually do?
• and where did you do it? (750 words?)
• Search log/diary• Results matrix• Tidying up your strategy• What did you find, where? • Explicit criterion = reproducable methodology
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
http://jech.bmj.com/content/61/12/1069.full.pdf
http://www.bmj.com/content/328/7446/991.full.pdf
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
introducing the research topicreviewing relevant literatureIdentify relevant sources (and then search them!)ReferencesKeeping up to DateWriting Up
Stopping
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYSearching – Do’s & Don’ts
• Don’t try to do the whole search in one line
• Don’t imagine that your first attempt will get all the articles you need
• Don’t imagine it’s something that can be rattled off quickly
• Don’t give up!
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYSearching – Do’s & Don’ts
• Do think of alternative ways of talking about your topic
• Do consider the various types of information that might be relevant
• Do learn from your hits and your misses
• Do remember that you still have to critically appraise each article
• Do ask for help
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARY
CAMBRIDGE UNIVERSITY LIBRARYMEDICAL LIBRARYHelp!
Isla Kuhn
Reader Services Librarian
Medical Library
Box 111
Addenbrooke’s Hospital
email: [email protected]
phone: (01223) (3)36750
web: http://library.medschl.cam.ac.uk
Thank you.