Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this...
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Transcript of Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this...
![Page 1: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/1.jpg)
Synaptic Transmission
•How a neuron communicates with another neuron and the effects of drugs on this process.
•Types of Neurotransmitters
![Page 2: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/2.jpg)
Synaptic Transmission: Neuron to Neuron Communication
• Axons branch out and end near dendrites of neighboring cells
• Axon terminals are the tips of the axon’s branches
• A gap separates the axon terminals from dendrites
• Gap is the Synapse
![Page 3: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/3.jpg)
Steps to Synaptic Transmission• Action Potential causes synaptic vesicle to open
• Neurotransmitter (NT) released into synapse
• NT fuses to receptor site in on receiving dendrite
• Receptor site opens and allows positive sodium ions to enter the dendrite triggering action potential in the next neuron.
![Page 4: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/4.jpg)
![Page 5: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/5.jpg)
![Page 6: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/6.jpg)
Neurotransmitters are LikeKeys to a Lock
• Neurotransmitter molecules have specific shapes
• When NT binds to receptor, it opens & positive ions enter
• Receptor molecules have binding sites
![Page 7: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/7.jpg)
Neurotransmitters Bonding at a Receptor Site
![Page 8: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/8.jpg)
Drugs Impact on Synaptic Transmission
![Page 9: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/9.jpg)
Some Drugs Work on Receptor Sites• Some Drugs are shaped extremely similar to a NT
and like a copy of a key unlock the receptor site
• Agonists: fit receptor well and mimic the NT causing Action Potential– e.g., nicotine
![Page 10: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/10.jpg)
Some Drugs Work on Receptor Sites• Some drugs are shaped like
neurotransmitters but do NOT unlock the receptor site thus blocking it from receiving natural NT.
• Antagonists: fit the receptor but poorly and block the NT stopping the action potential message– e.g., beta blockers
![Page 11: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/11.jpg)
Natural Neurotransmitters are like a key to a lock. They bond to the receptor site “unlocking” it
![Page 12: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/12.jpg)
Antagonist Drugs block the receptor site. Like a key in the wrong lock, they won’t open the
door/receptor site.
![Page 13: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/13.jpg)
Agonist drugs mimic neurotransmitters and open the receptor site
just like a copied key will unlock a door.
![Page 14: Synaptic Transmission How a neuron communicates with another neuron and the effects of drugs on this process. Types of Neurotransmitters.](https://reader036.fdocuments.in/reader036/viewer/2022062804/5697bf8e1a28abf838c8cdae/html5/thumbnails/14.jpg)
Addiction
How do drugs affect synaptic transmission? (5 min)