Symposium on

Biomolecular Structure,Dynamics &FunctionApril 29 – May 1, 2016Providence, RI

http://brown.edu/conference/sailing-the-protein-seas/

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Acknowledgements

Organizing Committee (alphabetical order)

Alexandra Deaconescu, Brown University, Providence, RI

Nicolas Fawzi, Brown University, Providence, RI

Rebecca Page, Brown University, Providence, RI

Wolfgang Peti, Brown University, Providence, RI

Local Organizing Committee (alphabetical order)

Laura Bailey, Department of Molecular Pharmacology, Physiology and Biotechnology

Megan Dupre, Facilities Management Brown

Tim Durning, Department of Molecular Pharmacology, Physiology and Biotechnology

Crystal Miller, Department of Molecular Pharmacology, Physiology and Biotechnology

Brown University, Providence, RI

Sponsors

Bruker (BioSpin, AXS & Daltonics), Sigma Aldrich-Isotec, Cambridge Isotope Laboratories,

Nanotemper, Art Robbins Instruments, Rigaku, Molecular Dimensions, Fisher Scientific, Eppendorf,

Thermo Scientific, New Era Scientific

and The Protein Society

Site Arrangements

We thank Chairs Kimberly Mowry (Department of Molecular Biology, Cell Biology and

Biochemistry), Wayne Bowen (Department of Molecular Pharmacology, Physiology and

Biotechnology) and Dean of Medicine Jack Elias for access to the resources of Brown University,

Providence, RI for this symposium.

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Directions for the Symposium

The Brown University campus is a residential campus and thus it will be possible to enter and leave the symposium facilities at any time during the event. Upon registration you will receive a name tag that will show that you attend the conference which will allow you to enter the Brown University buildings where the symposium will take place. The symposium registration desk will be located on Friday at Sayles Hall, which is at the heart of Brown University and start at ~4 pm. Registration on Saturday and Sunday will be possible next to the main auditorium at 85 Waterman Street, Providence, RI, where all lectures will be held. Driving directions to Brown University:

From the North or South on Interstate 95: Take Exit 22A to Downtown Providence. Continue straight on Memorial Boulevard. At the fourth set of lights, turn left onto College Street. At the top of the hill, turn left onto Prospect Street. Take your first right onto Waterman Street. The Stephen Robert ’62 Campus Center will be on your right.

From the East on Interstate 195: Take Exit 2 to South Main Street and continue for half a mile until the first set of traffic lights. Turn right onto College Street and then left at the top of the hill onto Prospect Street. Take your first right onto Waterman Street. The Stephen Robert ’62 Campus Center will be on your right.

From the Northwest: Follow Route 146 to I-95 South then follow directions above (from north and south). Parking Visitors may find parking on the streets in and around campus, or in Lot 68, also called the Power Street Parking Garage. Entrance to the garage is located at the intersection of Power and Thayer streets. The lot contains two Pay and Display parking pay stations. One is located at the Power Street entrance and the second is in the far corner of the lot by Brook Street. The Pay Stations accept credit cards (Visa, MasterCard, American Express, and Discover) and U.S. bills. (Note that the pay stations do not give change.) Brown maintains visitor spaces that meet ADA standards for accessibility in Lot 65, which is located on the south side of Benevolent Street between Thayer and Brook streets. Taxi from the airport: The fare from the airport to Downtown Providence is ~$35 and will take 15-20 minutes. To Brown from the downtown hotels: Brown is a short 5-10 minute walk from the Downtown Hotels. Please see attached map. The Hilton Hotel will have a shuttle van available for transport upon request – please inquire at the front desk of the hotels.

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Luggage Storage on Sunday Luggage storage is available at 85 Waterman Street on Sunday morning (Room 015 lower level). Luggage can be claimed at the end of the symposium (~1 pm), or upon request at earlier times on Sunday.

Poster Presentations

If you indicated you will be presenting a poster, your abstract has been assigned a number – please find the correlating number on the poster boards to locate your poster board. Pins will be provided. All posters will be presented on Friday, April 29, 2016. You should plan to put your poster up when you arrive and take it down at the end of the night.

Student and postdoc poster presenters will participate in a contest with three prizes for each session. Bring your A-game and let the best science and presenters win! The Poster Session is generously sponsored by the Protein Society.

Note: PIs, and students and postdocs selected for oral presentations are not eligible to participate in the poster competition.

Transportation in Providence

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MAPS AND DIRECTIONS

Providence, Hotels and the Brown

Campus

Hampton Inn

Hilton Providence

Biltmore

Conference

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Meeting Location on the Brown

Campus

Sayles Hall

Auditorium, 85 Waterman Street

Kasper, Saturday Dinner

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Symposium on Biomolecular Structure, Dynamics and Function

Brown University, Providence, RI

April 29 - May 1, 2016

PROGRAM

Friday, April 29, 2016

Afternoon Arrive / check in to hotel

4:00 pm Registration opens Sayles Hall

5:00 – 5:05 pm Welcome / Keynote speaker I intro (W. Bowen & W.

Peti)

85 Waterman Street Main Auditorium

Session Chair: W. Peti

5:05 – 5:50 pm

Keynote lecture I Peter Wright

The Scripps Research Institute “Navigating the protein seascape: role of disorder and

dynamics in protein function and dysfunction”

5:50 – 6:05 pm Yana K. Reshetnyak

University of Rhode Island

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“Membrane-associated folding and unfolding: Molecular mechanism and applications in medical

sciences”

6:05 – 6:30 pm

Ranajeet Ghose The City College of New York

“Canonical and Non-canonical Docking-Mediated Phosphorylation by the MAP Kinase ERK2”

6:30 – 11:00 pm Poster session – sponsored by The Protein Society

Vendors / Food & Drinks Sayles Hall

Saturday, April 30, 2016

Breakfast Hotels

8:30 – 8:35 am Keynote speaker II intro (W. Peti)

85 Waterman Street Main Auditorium

Session Chair: K. Gehring

8:35 – 9:20 am

Jane Dyson The Scripps Research Institute

“Characterizing Interactions of Large Proteins by NMR and other methods”

9:20 – 9:35 am Sanjay B. Hari

Massachusetts Institute of Technology “Quality Control of Membrane Proteins”

9:35 – 10:00 am

Mary Munson University of Massachusetts Medical School

“Subunit connectivity, assembly determinants, and architecture of the yeast exocyst complex”

10:00 – 10:15 am

Ariele Viacava Follis St. Jude Children’s Research Hospital

“Small molecule modulation of the apoptotic regulator protein BAX”

10:15 – 10:40 am Coffee break

10:40 – 10:45 am Keynote speaker III intro (N. Fawzi)

Session Chair: N. Fawzi

10:45 – 11:30 am Marius Clore

National Institute of Health “Unveiling Dark Matter in Biology”

11:30 – 11:45 am

Ivan Peran Stony Brook University

“Critical Analysis of the Collapse Transition in Protein Folding: A Combined FRET and SAXS Study”

11:45 – 12:05 pm

Ron Hills University of New England

“Coarse grain modeling of lipid-protein interactions and ABC transporters”

12:05 – 12:25 pm Payel Das

IBM Thomas J Watson Research Center

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“Characterization of Alzheimer's Protective and Causative Amyloid-beta Variants Using a Combination

of Simulations and Experiments”

12:25 – 12:50 pm

Dimitry M. Korzhnev University of Connecticut Health Center

“Structural view of the early events of the ADA2h folding from relaxation dispersion NMR and

computations”

1:00 – 2:00 pm Sandwich lunch box 85 Waterman Street +

Thayer Street

Session Chair: D. Eliezer

85 Waterman Street Main Auditorium

2:00 – 2:25 pm

Arthur G. Palmer, III Columbia University

“Protein dynamics from NMR and MD simulations: Lessons from ribonuclease H and GCN4”

2:25 – 2:40 pm

Bradley T. Falk University of North Carolina

“Probing intersubunit communication in the singly ligated state of dimeric thymidylate synthase”

2:40 – 3:05 pm

Kalle Gehring McGill University

“Cysteine phosphorylation, a novel regulatory protein modification”

3:05 – 3:30 pm Andrei T. Alexandrescu

University of Connecticut “Structural biology of phage proteins”

3:30 – 4:30 pm Coffee break + Meet a NSF PO

3:30 – 3:50 pm

Optional: Martin Fuchs Brookhaven National Laboratory

“NSLS-II beamlines for micro crystallography, FMX, and highly automated crystallography, AMX”

Session Chair: A. Palmer

4:30 – 4:55 pm

David Eliezer Weill Cornell Medical College

“IDPs on the brain: Disordered proteins and their interactions in brain function and dysfunction”

4:55 – 5:10 pm

Radhika Subramanian Harvard Medical School

“Building micron-scale cellular structures from nanometer-sized proteins”

5:10 – 5:35 pm

Francesca Massi University of Massachusetts Medical School

“RNA-binding domain disorder modulates the RNA destabilizing activity in the TTP family of proteins”

5:35 – 5:50 pm

Elizabeth Haglin University of Massachusetts - Amherst

“Signaling-related structural changes of chemoreceptor nano-arrays”

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5:50 – 6:15 pm

Blake Hill Medical College of Wisconsin

“A Targeted Mutation Identified Through pKa Measurements Indicates a Post-recruitment Role for

Fis1 in Yeast Mitochondrial Fission”

6:15 – 6:30 pm

Steffen Lindert Ohio State University

“Molecular Effects of Cardiac Troponin DCM Mutations on Calcium Sensitivity and Myofilament

Activation - An Integrated Multi-scale Modeling Study”

6:30 – 7:00 pm

Vincenzo Venditti Iowa State University

“Versatile dynamics in the C-terminal domain of bacterial Enzyme I”

7:00 – 7:15 pm

Dima Kozakov Stony Brook University

“Efficient global peptide docking using motif-derived fragments”

7:15 – 7:30 pm Break Thayer Street

7:30 – 9:30 pm Isotec Conference Banquet Kasper Multi-Purpose

Room

8:30 – 10:30 pm Shuttle Service to Downtown Providence

9:30 pm - … ‘Networking in Downtown Providence’

Discover the bars in Providence! Downtown Providence

Sunday, May 1, 2016

7:30 – 8:30 am Breakfast Hotels

8:30 – 8:35 am Keynote speaker IV intro (R. Page)

85 Waterman Street Main Auditorium

Session Chair: R. Page

8:35 – 9:20 am

Tania Baker Massachusetts Institute of Technology

“Unexpected activities and functions of the AAA+ protein unfoldases”

9:20 – 9:35 am

Michael J. Ragusa Dartmouth College

“Investigations into the Structure and Function of a Highly Conserved Cyanobacteria Protein”

9:35 – 10:00 am

Andrei A. Korostelev University of Massachusetts Medical School

“Ensemble cryo-EM: high-resolution structural dynamics of the ribosome under cellular stress”

10:00 – 10:15 am

Piotr Sliz Harvard Medical School

“Data publication with the structural biology data grid supports live analysis”

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10:15 – 10:40 am Alexander Shekhtman

University at Albany, SUNY “Probing Protein quinary structures by in-cell NMR”

10:40 – 10:55 am Coffee break

10:55 – 11:20 am

David Cowburn Albert Einstein College of Medicine

“Selective diffusion in the nuclear pore at the atomic scale”

11:20 – 11:35 am

Ying Zhang University of Rhode Island

“Using PSAMM for the Annotation and Quality Control of Genome-scale Metabolic Models”

11:35 – 12:00 pm

Sandor Vajda Boston University

“Statistical mechanics of protein-protein association”

12:00 – 12:15 pm

Scott A. Showalter Pennsylvania State University

“Structural Biophysics of Intrinsically Disordered Proteins”

12:15 – 12:20pm Closing Remarks

12:20 – 1:00 pm Sandwich lunch box

1:00 pm Farewell! See you hopefully in 2 years!