SYLLABUS BOOKLET OF PROPOSED 4-YEAR B.PHARM. … · proposed 4-year b.pharm. programme applicable...

SYLLABUS BOOKLET OF

PROPOSED 4-YEAR B.PHARM. PROGRAMME

Applicable to Academic Session 2014-15 and onwards

DEPARTMENT UNDERGRADUATE COMMITTEE (DUGC)

DEPARTMENT OF PHARMACEUTICS INDIAN INSTITUTE OF TECHNOLOGY (BHU)

VARANASI – 221 005

Syllabus Booklet of B.Pharm. Programme, Department of Pharmaceutics, IIT (BHU), Varanasi.

SEMESTER-WISE COURSE STRUCTURE OF 4-YEAR B.PHARM. PROGRAMME

SEMESTER 1

PC.Course Code.YY Course Code Course Name Contact hrs

(L--T--P) Credits

IS1.BL101.14 BL101 Biology 3‐‐1‐‐0 11

IS2.CY101.14 CY101 Chemistry ‐ I 2‐‐1‐‐2 10

IS3.PHY102.14 PHY102 Physics – II: Introduction to Engineering Electromagnetics 3‐‐1‐‐2 13

IE1.CMO103.14 CMO103 Engineering Thermodynamics 3‐‐1‐‐0 11

EP1.ME104.14 ME104 Engineering Drawing 1‐‐0‐‐3 6

EP2.ME105.14 ME105 Manufacturing Practice – I 0‐‐0‐‐3 3

IH1.H101.14 H101 Universal Human Values ‐ I: Self and Family 1‐‐1‐‐0 5

Total 13--5--10 59

LM1.HL101.14 HL101 Basic English# 2‐‐0‐‐1 7

Total 15--5--11 66

GY1.PE101/CP101.14 PE101/CP101 Elementary Physical Education/Creative Practice##

0‐‐1‐‐3 5

SEMESTER 2


(L--T--P) Credits

IS4.MA101.14 MA101 Engineering Mathematics – I 3‐‐1‐‐0 11

IS5.CY103.14 CY103 Essentials of Biochemistry 3‐‐0‐‐2 11

EP3/DC1.PH101.14 PH101 Basics of Pharmaceutical Sciences 3‐‐0‐‐3 12

IE2.CSO101.14 CSO101 Computer Programming 3‐‐1‐‐2 13

EP4.ME106.14 ME106 Manufacturing Practice – II 0‐‐0‐‐3 3

IH2.(H103/H104)/ (H105/H106).14

H103/H104/ H105/H106

(Development of Societies/History & Civilization)/(Philosophy/Education & Self) 2‐‐1‐‐0 8

Total 14--3--10 58

GY2.PE101/CP101.14 PE101/CP101 Elementary Physical Education/Creative Practice#

0‐‐1‐‐3 5

SEMESTER 3


(L--T--P) Credits

IE3.CHO102.14 CHO102 Fluid Mechanics 3‐‐1‐‐0 11

MC1.BO202.15 BO202 Human Physiology 3‐‐0‐‐0 9

IS6.MA202.15 MA202 Probability and Statistics 3‐‐1‐‐0 11

DC2.PH211.15 PH211 Physical Pharmaceutics 2‐‐0‐‐3 9

DC3.PH221.16 PH221 Pharmaceutical Chemistry 2‐‐0‐‐3 9

IH3.(H103/H104)/ (H105/H106).14

H103/H104/ H105/H106

(Development of Societies/History & Civilization)/(Philosophy/Education & Self)

2‐‐1‐‐0 8

Total 15--3--6 57


SEMESTER 4


(L--T--P) Credits

IE4.CMO103.15 CMO103 Heat and Mass Transfer 3‐‐1‐‐0 11

DC4.PH222.15 PH222 Bioorganic and Medicinal Chemistry 2‐‐0‐‐3 9

DC6.PH231.15 PH231 General Pharmacology 3‐‐0‐‐2 11

DC7.PH241.15 PH241 General Pharmacognosy 2‐‐0‐‐3 9

DC5.PH251.15 PH251 Pharmaceutical Analysis 2‐‐0‐‐2 8

DP1.PH291.15 PH291 Exploratory Project 0‐‐0‐‐5 5

IH4.HL201.14 HL201 Universal Human Values ‐ II: Self, Society and

Family 1‐‐2‐‐0 5

Total 13--3--15 58

SEMESTER 5


(L--T--P) Credits

OE1………. Open Elective I* 3‐‐0‐‐0 9

MC.BO301.16 BO301 Microbiology and Biotechnology 2‐‐0‐‐3 9

DC8.PH311.16 PH311 Pharmaceutical Technology 3‐‐0‐‐2 11

DC9.PH331.16 PH331 General Pharmacotherapeutics 3‐‐0‐‐0 9

DC10.PH341.16 PH341 Natural Drugs and Excipients 3‐‐0‐‐2 11

LM1.HL301.16 HL301 Professional Communication 2‐‐1‐‐0 8

Total 16--1--7 57

DPx.PH391.16 PH391 Stream Project (Hons.) 0--0--5 5

GY3.PE301.16 PE301 Advanced Physical Education 1‐‐1‐‐5 10

SEMESTER 6


(L--T--P) Credits

OE2………. Open Elective II* 3‐‐0‐‐0 9

DC11.PH301.16 PH301 Pharmaceutical Jurisprudence 2‐‐0‐‐0 6

DC12.PH321.16 PH321 Chemistry of Synthetic Drugs 3‐‐0‐‐2 11

DE1.PH312/PH322/

PH332/PH342.16

PH312/PH322/

PH332/PH342 Core/Bouquet Elective I

# (1 out of 4 Courses) 3‐‐0—3 12

DP2.PH392.16 PH392 Regular Stream Project 0‐‐0‐‐10 10

IH5.H301.16 H301 Humanities Course – New 3‐‐0‐‐0 9

Total 14--0-15 57


SEMESTER 7


(L--T--P) Credits

OE3………. Open Elective III** 3‐‐0‐‐0 9

DC13.PH451.17 PH451 Pharmaceutical Instrumental Analysis 2‐‐0‐‐3 9

DC14.PH431.17 PH431 Chemotherapy 3‐‐0‐‐0 9

DE2.PH411/PH421/ PH432/PH441/

PH452.17

PH411/PH421/ PH432/PH441/

PH452 Core/Bouquet Elective II

# (1 out of 5 Courses) 3‐‐0‐‐0 9

DP3.PH401.17 PH401 Industrial Visit/Training 0‐‐0‐‐0 5

DP3.PH491.17 PH491 Regular Stream Project 0‐‐0‐‐10 10

LM2.HL501.17 HL501 Academic Writing in Science & Technology 2‐‐1‐‐0 8

Total 13--1--13 59

SEMESTER 8


(L--T--P) Credits

OE4…………. Open Elective IV*** 3‐‐0‐‐0 9

DC15.PH412.17 PH412 Dosage Formulation Design 2‐‐0‐‐3 9

DC16.PH442.17 PH442 Analytical Pharmacognosy 2‐‐0‐‐3 9

DE3.PH413/PH422/

PH433/PH443/

PH453.17

PH413/PH422/

PH433/PH443/

PH453

Core/Bouquet Elective III# #

(1 out of 5

Courses) 3‐‐0‐‐0 9

DC17.PH402.17 PH402 Seminar 0‐‐0‐‐2 0

IH6.H401.17 H401 Humanities Course ‐ New 3‐‐0‐‐0 9

Total 13--0--8 45

DPx.PH492.17 PH492 Stream Project (Hons.) 0‐‐0‐‐10 10

Total 15--0--15 55

TOTAL CREDITS OF B.PHARM. PROGRAMME 445

*Open Elective 1: Bioinformatics/Any other Course from sister departments

**Open Elective 2: Industrial Management/Bioprocess Planning & Management/Any other Course from sister

departments

***Open Elective 3: Tissue Engineering/Polymers in Medicine/Any other Course from sister departments

#Dept. Core Elective I: PH312:Hospital and Clinical Pharmacy/PH322: Chemistry of Natural Drugs/PH332:

Neuropharmacology/PH342: Industrial Pharmacognosy #Dept. Core Elective II: PH411: Biopharmaceutics/PH421: Computational Chemistry/PH432:

Neuropharmacotherapeutics/PH441: Plant Tissue Culture/PH452: Spectroscopy (OE for others) ##

Dept. Core Elective III: PH413: Industrial Pharmacy/PH422: Computational Drug Design/PH433:

Toxicology/PH443: Nutraceuticals and Herbal Cosmetics/PH‐453: Quality Assurance (OE for others)


SUMMARY OF CREDIT ALLOCATION

No. of Courses Component Code Type of Course Prescribed Allocated

6 IS Institute Science: 6 Courses 62‐‐84 67

4 IE Institute Engg: 4 Courses 41‐‐60 46

18 DC/MC Dept Core (16+Multi‐Core (2): 18 Courses 105‐‐155 157

3 DE/PE Dept. Elective: 3 Courses 30‐‐60 30

4 OE Open Elective: 4 Courses 35‐‐70 36

4 DP Dept. Project/Ind. Visit: 4 Courses 20‐‐50 30

4 EP/PP Engg/Pharmacy Practice: 4 Courses 20‐‐24 24

6 IH Institute Humanities: 6 Courses 41‐‐60 44

2 LM Language /Management Courses 20‐‐24 16

GY Gymkhana Courses

51 TOTAL CREDITS 450

4-YEAR B.PHARM. PROGRAMME - SUMMARY SHEET OF PROGRAMME COMPONENTS

S. No. Category Programme Components

4-Year Programme

% (Approved

credit limits)

% (Allocated

credits)

1. HU Humanities and Social Science* 10

(41‐50) 44

2. IS Science* 15

(62‐84) 67

3. IE Institute Requirement Engineering/ Pharmacy*

10 (41‐60)

46

4. EP

Engineering Drawing (Manual and Computer Aided), Manufacturing Practices and Practice course of Department/ School*

5 (20‐24)

24

5. LM Language and Management* 5

(20‐24) 16

6. DC/MC Department/Programme Core (Includes Stream Courses)

25‐30 (105‐155)

157

7. DE/BE Department/Programme Elective (Includes Stream Courses)

7‐10 (30‐60)

30

8. OE

Open Elective (Interdisciplinary Stream courses from Science/ Engineering/Pharmacy) (Room for Minor with some additional Credits)

8‐15 (35‐70)

36

9. DP Project/ Industrial visit/ Training 5‐10

(20‐50) 25


DETAILED SYLLABI OF PROPOSED 4-YEAR B.PHARM. PROGRAMME

SEMESTER 1 BIOLOGY

1. GENERAL

1.1. COURSE TITLE: Biology

1.2. *COURSE CODE: IS.BL101.14

1.3. CONTACT HRS: 3‐1‐0

1.4. CREDITS: 11

1.5. *SEMESTER OFFERED: Odd

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. K Sairam (Convener), Dr. A.N. Sahu (PH), Dr.

Pradeep Srivastava (BC), Prof. Devendra Mohan (CE)

2. OBJECTIVE

To provide a basic understanding about human and plant systems. This will enable students to

undertake advanced level courses pertaining to pharmaceutical and biomedical sciences, and

other interdisciplinary engineering courses.

3. COURSE CONTENTS

Unit I. Introduction to Biology: Classification of plant and animal kingdoms; introduction to

human body: Levels of body organization, basic anatomical terminology; introduction to

plants with its primary and secondary uses. (4 Lectures)

Unit II. Cell and molecular biology of animal and plant cell: Plasma membrane, cell wall,

chemical and electrical properties of membrane, transport across the membrane, mechanism

of cell communication, cell junctions, cell adhesion & extracellular matrix; Mitochondria,

Chloroplast and photosynthesis; cytoplasm, cell organelles, nucleus, cell division, aging of

cells, cellular diversity and disorders related to cells. (13 Lectures)

Unit III. Animal and plant tissue: Elementary understanding of animal and plant tissues; aging

of tissues and disorders related to it. Detail understanding of components of blood, their

functions and disorders. (8 Lectures)

Unit IV. Basic anatomy of cardiovascular, digestive, endocrine, integumentary, nervous,

respiratory, skeletal, urinary & reproductive systems; basic morphology and microscopy of

plants. (14 Lectures)

4. READINGS

Tortora Grabowski, Principles of anatomy and physiology, 10th edn., John Wiley & Sons, Inc.

Duta AC, Botany, 6th edn., Oxford university press.

5. OUTCOME OF THE COURSE

Equip the students with the basic understanding cells, tissues and systems and disorders of

humans and plants.

Help to acquire essential knowledge to choose specialized areas with additional requirements

like Human physiology, space physiology , pharmacology, space pharmacology, biomedical

devises, biocompatible devices, bio‐ceramic devises, bio‐sensors, herbal drug discovery,

neural networks, artificial intelligence, computational biology, computational pharmacology,

New drug discovery, community healthcare, Miner’s health etc.


CHEMISTRY- I

1. GENERAL

1.1. COURSE TITLE: Chemistry ‐ I

1.2. *COURSE CODE: IS.CY101.14


1.4. CREDITS: 10


1.6. PREREQUISITE: None

1.7. SYLLABUS COMMITTEE MEMBERS: Prof. S. H. Hasan, (Convener), Dr. I. Sinha, Dr. Manisha

Malviya

2. COURSE CONTENT

Unit I: Titrimetric Analysis (4 Lectures)

Introduction to titrimetric analysis; acid‐base, Redox and complexometric titrations.

Unit II: Coordination Chemistry (5 Lectures)

General introduction to ligands and complexes, Crystal field theory as applicable to metal

complexes, Crystal field splitting in octahedral and tetrahedral complexes, Factors affecting

crystal field parameter , Jahn‐Teller distortion, Square planar complexes, Colour of complexes.

Unit III: Organic Reaction Mechanisms (5 Lectures)

Nucleophilic Substitution Reactions: Brief review of nucleophilic substitution reactions at

saturated carbon atom, Substitution reactions at allylic substrates, Mechanisms and

stereochemistry of SNi and Neighboring group participation reactions, Factors affecting

nucleophilic substitution reactions.

Unit IV: Elimination Reactions

Mechanism of E1 and E1cb reactions. Mechanism and stereochemistry of E2 reactions, anti,

syn and pyro Elimination reactions, Mechanism and stereochemistry of electrophilic addition

reaction. (4 Lectures)

Unit V: Chemical Kinetics (5 Lectures)

Concepts of rate, rate constant, Order and molecularity of elementary and multi‐step

reactions, First and second‐order reactions, determination of rate law, reversible reactions,

concurrent and consecutive reactions first order reactions.

Unit VI: Photochemistry (4 Lectures)

Laws of photochemistry, Quantum yield, experimental determination of quantum yield,

Kinetics of photochemical reactions (simple and chain reactions), Photo‐physical processes:

fluorescence, phosphorescence (with spectroscopic consideration), Photosensitization.

3. READINGS

1. F. A. Cotton, G. Wilkinson, C.A. Murillo and M. Bochmann, Advanced Inorganic Chemistry,

John Wiley, 6th Ed., 1999.

2. Ellen AKeiter, James E. Huheey, Okhil K. Medhi, Richard L. Keiter, Inorganic Chemistry:

principles of structure and reactivity, 4th Ed., Pearson Education, 2012.

3. J.D. Lee, Concise Inorganic Chemistry, 5Th Ed., Wiley India Pvt. Ltd.

4. Vogel’s text book of Quantitative chemical Analysis, revised by G.H. Jeffery, J. Bassett, J.

Mendham and R.C. Denny, Longman, UK.


5. Ira N. Levine, Physical Chemistry, Tata McGraw Hill.

6. R. A. Alberty and R. J. Silbey, Physical Chemistry, John Wiley & Sons.

7. G. W. Castellan, Physical Chemistry, Narosa Publishing House.

8. R.T. Morrison and R. N. Boyd, Text book of Organic Chemistry, Prentice Hall, New Delhi, 6th

edition, 1992

9. P. Sykes, Guide book to Reaction Mechanism in Organic Chemistry, Longman, London, 6th

edition, 1996.

10. T.W.G. Solomon, C.B. Fryhle Organic Chemistry, John Wiley & sons, New York. 8th edition,

2004.

ENGINEERING THERMODYNAMICS

1. GENERAL

1.1. COURSE TITLE: Engineering Thermodynamics

1.2. *COURSE CODE: IE.CHO101.14


1.4. CREDITS: 11

1.5. *SEMESTER OFFERED: Both

1.6. SYLLABUS COMMITTEE MEMBERS: Prof. P. Ahuja (CH) (Convener), Prof. S.P. Singh (CR),

Prof. B.N. Sharma (MT), Prof. M. Prasad (ME), Dr. S.S. Mondal, Dr. J. Sirkar, Dr. B.

Eshpuniyani

2. OBJECTIVE

The course shall prepare the students to understand the laws of thermodynamics and apply

them to various engineering problems and also to understand the thermodynamic property

relations and their usage in thermodynamic property estimation.

3. COURSE CONTENTS

Unit I: Introduction. (2 Lectures)

Concept of internal energy, enthalpy, heat and work. State and path functions. Degrees of

freedom for saturated and superheated steam and subcooled liquid. Extensive and intensive

properties. Work done in an internally reversible non‐flow process.T‐V, P‐V, and P‐T diagrams

of a pure substance.Standard Molar heat capacity (of pure ideal gas, pure liquid and pure

solid) as a function of temperature. Zeroth law of thermodynamics.

Unit II: Importance of equations of state. (2 Lectures)

Ideal gas equation of state. van der Waals fluid equation of state.Reduced temper ature and

reducedpressure.Two‐parameter and three‐parameter Law of corresponding states.Molar

volume of saturated vapour and saturated liquid. Compressibility factor of gases and liquids.

Unit III: First law and its applications. (6 Lectures)

Non‐flow processes: Energy balance in a non‐flow process. Constant pressure process,

constant volume process, constant temperature process, adiabatic process, polytropic

process Steady Flow processes: Energy balance in a steady flow process. Work done in an

steady flow process. Nozzles and diffusers, turbines and compressors, multistage compression

with intercoolers. Transient flow processes, uniform flow process, charging process,

discharging process.


UnitIV: Second law and its applications. (6 Lectures)

Carnot cycle. Clausius inequality. Limitations of first law. Entropy balance for closed system.

Reversible and irreversible expansion at constant temperature. Irreversibility due to heat

transfer over temperature difference.Increase of entropy principle.Entropy balance for

control volume.Adiabatic efficiency of steady flow devices.Statistical interpretation of

entropy.Third law of thermodynamics.

Unit V: Exergy (or Availability). (4 Lectures)

Exergy of heat.First and second law efficiency of a heat engine.Reversible useful work of non‐

flow processes, Exergy of non‐flow process.PdV versus reversible work for non‐flow process.

Irreversibility of non‐flow process. Lost work. Reversible work of steady flow process.

Comparison of Internally reversible, reversible and irreversible processes.

Unit VI: Chemical reactions. (3 Lectures)

Standard enthalpy, entropy and Gibbs energy of formation at 298.15 K. Standard enthalpy

change of reaction as a function of temperature. Standard entropy change of reaction as a

function of temperature. Standard Gibbs energy change of reaction as a function of

temperature.

Unit VII: Thermodynamic property relations of pure substances. (8 Lectures)

Introduction to the thermodynamic properties of idealized and real fluids. Thermodynamic

Relations for dU, dH, dA, and dG. Maxwell relations. General equation for dU, dH, dS. Volume

expansivity and isothermal compressibility. General equation for molar heat capacities. Joule‐

Thomson coefficient. Clapeyron equation. Antoine equation. Residual property. dU, dH, and

dS for ideal gases and real gases. Calculations of Joule‐Thompson coefficient and residual

properties of gases and liquids and molar heat capacity at constant pressure using van der

Waals equation of state. dG=RTdlnf, and the importance of fugacity in relation to equilibrium.

Unit VIII: Thermodynamic cycles. (7 Lectures)

Rankine cycle. Comparison of Carnot and Rankinecycles.Reheat cycle. Regenerative cycle. Air

standard power cycles. Otto cycle. Diesel cycle. Braytoncycle. Coefficient of Performance.

Reversed Carnot Cycle. Vapour‐compression refrigeration cycle. Ammonia absorption

refrigeration cycle. Linde‐Hampson liquefaction cycle.

4. READINGS

4.1 TEXTBOOK:

Nag, P.K., Engineering Thermodynamics, Third Edition, Tata McGraw‐Hill, New Delhi, 2005

4.2 *REFERENCE BOOKS:

1. Cengel, Y.A. and Boles, M.A., Thermodynamics: An Engineering Approach, McGraw‐Hill,

New York, 1988

2. Howell, J.R. and Buckius, R.O., Fundamentals of Engineering Thermodynamics, McGraw‐

Hill, Singapore, 1987

3. Huang, F.F., Engineering Thermodynamics: Fundamentals and Applications, Macmillan

Publishing Co., 1976.

4. Jones, J.B. and Hawkins, G.A., Engineering Thermodynamics, Prentice Hall of India, 2000.

5. Moran, M.J. and Shapiro, H.N., Fundamentals of Engineering Thermodynamics, Fourth

Edition, John Wiley, 2000


6. Rogers, G. F. C. and Mayhew, Y. R., Engineering Thermodynamics, Work and Heat Transfer,

Fourth Edition, Pearson Education, New Delhi, 1992

7. Van Wylen, G.J. and Sonntag, R.E., Fundamentals of Classical Thermodynamics, Third

Edition, John Wiley, New York, 1985

8. Wark, K., Thermodynamics, Fourth Edition, McGraw‐Hill, New York, 1983

9. Ahuja, P., Chemical Engineering Thermodynamics, PHI Learning, 2009


The students have learnt to apply first and second laws of thermodynamics to various

engineering problems and also learnt the usage of thermodynamic property relations for

estimation of thermodynamic properties using steam tables and equations of state.

PHYSICS II - INTRODUCTION TO ENGINEERING ELECTROMAGNETICS

1. GENERAL

1.1. COURSE TITLE: Introduction to Engineering Electromagnetics

1.2. *COURSE CODE: IS.PHY102.14


1.4. CREDITS: 13



1.7. SYLLABUS COMMITTEE MEMBERS: Dr. (Mrs.) A. Mohan (Convener), Prof. B. N. Dwivedi

Dr. D. Giri, Dr. P. Singh, Dr. R. Prasad, Dr. A. Srivastava

2. OBJECTIVE

This novel course is designed to cater to the needs of foundation in modern technology.

3. COURSE CONTENTS

Unit I: Physical concepts of vector operators: (4 Lectures)

Gradient, Divergence and Curl. Scalar and Vector fields, Gauss’ divergence theorem, and

Stokes’ theorem.

Unit II: Axiomatic treatment of Maxwell’s equations: (10 Lectures)

Continuity equation, Displacement current, Velocity‐independent and Velocity‐dependent

potentials. Poisson and Laplace equations and their applications.

Unit III: Electromagnetism: (13 Lectures)

Ampère's law. Faraday's law of induction. Lorentz force and modified form of Ohm’s law.

Electromagnetic lenses. Physical significance of magnetic vector potential. Electric and

magnetic energy densities. Electromagnetic wave equations in terms of electric field and

magnetic field, and also in terms of magnetic vector potentialand electric scalar potential in

free space and in a medium with their solutions. Coulomb gauge, Lorentz gauge and gauge

transformations. Energy flow in an electromagnetic field: Poynting vector and Poynting

theorem.

Unit IV: Electromagnetic waves in different media: (5 Lectures)

Propagation of electromagnetic waves in free space, Dielectric and Conducting media.

Reflection and transmission of electromagnetic waves at interfaces. Fresnel’s equations, and

Brewster’s law.


Unit V: Some illustrations: (6 Lectures)

Interference, Diffraction, and Polarization of electromagnetic waves. Their applications in the

visible range of the electromagnetic spectrum.

4. READINGS

4.1 TEXT BOOKS:

1. Electromagnetic Fields and Waves by Paul Lorrain, Dale R. Corson and Francois Lorrain

2. Introduction to Electrodynamics by David J. Griffiths

3. Engineering Electromagnetics by William H Hayt

4. Electricity and Magnetism by M.H. Nayfeh and M.K. Brussel


Feynman Lectures on Physics, Volume II


Every student in Engineering & Technology will be able to appreciate the content and quality

of topics being covered in his branch.

ENGINEERING DRAWING

1. GENERAL

1.1. COURSE TITLE: Engineering Drawing

1.2. *COURSE CODE: EP.ME104.14


1.4. CREDITS: 06



1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S. K. Shah (Convener), Dr. Amit Tyagi, Dr. D. Khan,

Dr. U. S. Rao (ME)

2. OBJECTIVE

Technical drawing is the language of engineering. The objective of this course is to learn

initially the basic principles involved in the projection of points, lines, lamina and solids. As

well this course is focused towards the interpenetration of solids, development of surfaces,

isometric drawings and some basics of computer aided drafting software. It is expected that a

student should learn this subject in a very systematic way to develop the skill to express

effectively his/her idea about an object to others through drawings.

3. COURSE CONTENTS

Unit I: (12 Lectures)

Instruments used, Lettering, Types of Lines used, Types of Projections in use, Dimensioning of

Figures, etc.; Orthographic Projections of Points, Lines & Lamina

Unit II: (16 Lectures)

Projection of Solids; Section of Solids & its Projections; Interpenetration of Solids & Curve of

Interpenetration; Development of Surfaces.

Unit III: (12 Lectures)

Isometric Drawing & Isometric Projection; Free‐Hand sketching of Engineering Components

Unit IV: (12 Lectures)


Introduction to Drafting Software (AutoCAD) & its Basic Commands, Solving Problems using

AutoCAD.

4. READINGS

1.1. TEXT BOOKS

1. Title: Engineering Drawing Author: N. D. Bhatt

2. Title: Engineering Graphics With Autocad Author: James D. Bethune

1.2. REFERENCE BOOKS

1. Title: Engineering Drawing & Graphics Author: K. Venugopal

2. Title: Engineering Drawing Author R. K. Dhawan

3. Title: Engineering Drawing Author: M. B. Shah & B. C. Rana


It is anticipated that after completion of the course, a student would be in a position to

study/guide basic engineering drawings required in workshop for the fabrication purposes.

Also this basic course will help the students to handle effectively the course on machine

drawing.

MANUFACTURING PRACTICE I & II

1. GENERAL

1.1. COURSE TITLE: Manufacturing Practice I & II

1.2. *COURSE CODE: EP.ME105.14&EP.ME106.14


1.4. CREDITS: 3


1.6. SYLLABUS COMMITTEE MEMBERS: Prof. A. K. Jha (Convener), Prof. Santosh Kumar, Dr.

M.Z. Khan Yusufzai, Dr. M. Vashista (ME)

2. OBJECTIVE

To make the students familiar with various manufacturing processes and to get an on hand

experience on these processes. Impart practical knowledge about the capabilities of

manufacturing processes and how these processes could be used to produce various types of

components and products.

3. DELIVERABLES

To develop skill and confidence among the students to successfully use various manufacturing

processes and to understand the difficulties faced by the personnel working on these

manufacturing processes.

4. PRACTICE PLAN

1. Manufacturing Practice I(Total hours: 3 hours per week x 10 weeks=30 Hours)

i. Foundry (1 turn)

ii. Pattern Making (1 turn)

iii. Material joining and Deposition Processes (2 turns)

iv. Metal forming processes (1 turn)

v. Demonstration of Videos on Manufacturing Processes (1 turn)

vi. Project work‐I (4 turns)


2. Manufacturing Practice II(Total hours: 3 hours per week x 10 weeks=30 Hours)

i. Centre Lathe (1 turns)

ii. Fitting (1 turn)

iii. Milling (1 turn)

iv. Shaping (1 turn)

v. CNC (1 turn)

vi. Demonstration of Videos on Manufacturing Processes (1 turn)

vii. Project work‐II (4 turns)

Note: (i) 1 turn means contact duration of three hours

(ii) Project work I & II may be combined into a larger project

5. SYLLABUS

MANUFACTURING PRACTICE I EP.ME105.14

Unit I: Foundry: Demonstration of foundry tools, equipments and furnaces, Preparation of

simple sand moulds along with the gating system and risers

Unit II: Pattern Making: Importance of woodworking Demonstration of carpentry tools,

equipments, carpentry processes and wood working joints. Preparation of single piece

pattern.

Unit III: Material joining and Deposition Processes: Classification of various welding and

joining processes, types of welding joints, Demonstration of gas welding, arc welding,

resistance welding. Practice of manual metal arc welding process.

Unit IV: Demonstration of setup for electroplating, process details and safety requirements.

Practice of copper and nickel plating of mild steel samples.

Unit V: Metal forming processes: Demonstration of black smithy tools and equipments. Hot

and cold working. Practice of open die forging process. Sheet metal material, tools and

machines. Sheet metal joints. Practice of preparing a sheet metal component having joint.

Unit VI: Demonstration of Videos on Manufacturing Processes

Unit VII: Project work‐I: Preparation of a real life job using the processes practiced in

manufacturing practice I.

MANUFACTURING PRACTICE II: EP.ME106.14

Unit I: Centre Lathe: Classification and types of lathe, parts and components of a lathe.

Demonstration of various turning operation. Practice of a few turning operations on a centre

lathe. Cutting tool.

Unit II: Fitting: Demonstration of various types of files, saws, marking and clamping tools.

Drilling and tapping. Practice of a assembling and fitting a job.

Unit III: Milling: Classification and types of milling machines, parts and components of a

milling machine. Milling cutter, Indexing and gear cutting.

Unit IV: Shaping: Parts and components of a shaper and planer. Quick return mechanism.

Practice on preparing component using shaper

Unit V: CNC: Specifications of a CNC Machine, difference between a conventional machine

and CNC Machines. Types of CNC Machine. Basics of CNC Programming. Writing a CNC

program and executing it on a CNC Machine.

Unit VI: Demonstration of Videos on Manufacturing Processes


Unit VII: Project work‐II: Preparation of a real life job using the processes practiced in

manufacturing practice II.

6. BOOKS

i. Workshop Technology in SI Units (Part ‐ 1) Author: W. A. J. Chapman, Publisher: CBS

Publications

ii. Workshop Technology in SI Units (Part ‐ 2) Author: W. A. J. Chapman, Publisher: CBS

Publications

iii. Workshop Technology in SI Units (Part ‐ 3) Author: W. A. J. Chapman, Publisher: CBS

Publications

UNIVERSAL HUMAN VALUES 1: SELF AND FAMILY

1. GENERAL

1.1. COURSE TITLE: UNIVERSAL HUMAN VALUES 1: SELF AND FAMILY

1.2. COURSE CODE: IH.H101.14


1.4. CREDITS: 5

1.5. SEMESTER OFFERED: Odd

1.6. PRE‐REQUISITES: 4‐day Harmony – 1 Workshop (co‐requisite)

2. OBJECTIVE

The objective of the course is four fold:

1. Sensitization of student towards issues in all dimensions of life.

2. Inculcation of self reflection.

3. Understanding (clarity) of relationships, and family.

4. Exposure to issues in society and environment.

5. Development of commitment and courage to act.

2.1. Sensitization of student towards issues in all dimensions of life

There are a whole range of issues which one faces in life towards which the young students

are generally unfamiliar and therefore insensitive. Almost all the concerns ‐ environmental,

societal, familial or personal, are result of human action. Sensitization towards them

therefore is an important step.

2.2. Inculcation of Self Reflection

Human action is governed by various internal factors primarily the beliefs one holds, and

therefore ‘looking‐in’ becomes essential, to see what beliefs one is holding, whether they are

really true or not, if they are not true, then what could be the process to get the "right" belief

and then further validate it.

Most of the young people are somehow trained to look only “outside”. The motivation and

the skill to look inside are missing. Inculcation of self reflection in students will result in them

becoming more responsible, honest and trustworthy. Lack of such qualities in individuals is

major concern of organizations, institutions and society in general.

2.3. Understanding (Clarity) of Human Relationships and Family.

It will try to show that relationships and material prosperity are the basic desire for a human

being. Two global problems which we face today are war (including terrorism) and imbalance


in nature (global warming). If we look at reasons for war, the fundamental cause is: Human

Being is in opposition to other Human Being. Therefore one is willing (or gets compelled) to

exploit others. This is due to lack of understanding of relationships.

2.4 Exposure to Issues in Society and nature (larger manmade systems and Nature)

To show that the fundamental reasons for imbalance in nature are: pollution and resource

depletion. Both these aspects are result of consumerist model of development.

To show how harmony can be ensured at following levels of our living: individual, human‐

human relationships, larger society, Various social systems like education system, economic

system, political system and others, and rest of the nature.

2.5. Development of Commitment and Courage to Act.

If the understanding is right, then the actions become right. Commitment and courage to act

are considered consequences of right understanding in an individual. In the course, an

attempt will be made to build right understanding in the individual, and then further plan of

actions will also be discussed in order to implement the understanding in various life

situations in the right manner.

3. COURSE CONTENTS

Following are the topics to be covered in broadly the given sequence.

Unit I: Motivation and Objectives of Human Values Course.

Introduction to the objectives of the course. Content and process of the course including

mode of conduct. Daily life as lab for the course. Activities in the course.

Unit II: Purpose of Education

How human being has a need for Knowledge, what should be the content of knowledge, how

the content should be discussed in education. Complimentarily of skills and values, how the

current education system falls short.

Unit III: Peers Pressure, Social Pressure

In various dimensions of life, how do these things work. What is the way out? In the context

of education, peer pressure etc. movie “TaareZameen Par” can be used.

Unit IV: Concept of Competition and Excellence

How competition leads to degradation of self and relationships. How excellence is the basic

need of a human being. What is excellence? Movie “Fearless” can be used to discuss the

concept.

Unit V: Time Management

How does one deal with myriads of activities in college? Focus of the mind.

Unit VI: Concept of Preconditioning.

How preconditioning affects our thinking, behavior, work, relationships, society and nature.

How do we develop pre‐conditioning? What are the various sources of preconditioning? How

do we evaluate our Preconditioning? How do we come out of it?

Unit VII: Concept of Natural Acceptance in Human Being

What is natural acceptance? How can the concept of natural acceptance be used to evaluate

our preconditioning. Universal nature of natural acceptance. Are anger, jealousy, hatred

natural? How do we feel when we experience them? Which feelings are natural for a human

being and which are not?


Unit VIII: Understanding Relationships.

a) Are relationships important?

What is the role of relationships in our life? If relationships are important then why they are

important? If they are important then why it is the case that we are not discussing them?

What are the notions/conditions and factors which stop us to explore more into relationships.

Relationships in family and extended family. Dealing with anger. Show film “Right Here, Right

Now”.

b) Basic expectations in relationships. Seven types of relations.

c) Gratitude as a universal value in relationships. Discuss with scenarios. Elicit examples

from students’ lives.

d) Nine universal values in human relationships. Trust as the founding value.

e) Concept of acceptance. Unconditional acceptance in relationships.

f) Our preconditioning affecting our relationships.

Our relationships with subordinate staff, with people of opposite gender, caste, class, race.

Movie “Dharm” (set in Varanasi) can be used to show the conflict between preconditioning

and relationships. How relationships have the power to force a person to change his

preconditioning.

Unit IX: Concept of prosperity

Material goods and knowledge of one's physical needs is essential for feeling of prosperity.

What role others have played in making material goods available to me: Identifying from

one’s own life.

Unit X: Idea of Society.

What is a society?

What constitutes a society?

What systems are needed for a society to work?

What is the purpose of society and various systems which are working in it?

How understanding of Human Nature is important in order to understand the purpose of

Society and various social systems? And what happens when this understanding is lacking?

Unit XI: Idea of decentralization of politics, economics, education, justice etc. Its comparison

with centralized systems. The idea of Swaraj. Various social initiatives by NGOs, social

organizations and other people. (If time permits)

Unit XII: Balance in nature

a) Balance which already exists in nature.

b) How human beings are disturbing the balance. Resource depletion and pollution.

Our own role in wastage of electricity, water and in use of plastics. Waste management.

(Show episode on city waste from SatyamevaJayate 2.)

c) Issues like global warming, animal extinction.

Show “Story of Stuff” documentary film. “Home” film can also be used.

4. READINGS

4.1 Text Books

1. Human Values and Professional Ethics by R R Gaur, R Sangal, G P Bagaria, Excel Books, New

Delhi, 2010.


4.2 Reference Books

1. The Story of Stuff (Book).

2. The Story of My Experiments with Truth ‐ by Mohandas Karamchand Gandhi

3. On Education ‐ J Krishnamurthy

4. Siddhartha ‐ Hermann Hesse

5. Old Path White Clouds ‐ ThichNhatHanh

6. On Education ‐ The Mother

7. Diaries of Anne Frank ‐ Anne Frank

8. Life and Philosophy of Swami Vivekananda

9. Swami Vivekananda on Himself

10. Small is Beautiful ‐ E. F Schumacher.

11. Slow is Beautiful ‐ Cecile Andrews

12. Jeevan Vidya: Ek Parichaya, A Nagaraj, Jeevan Vidya Prakashan, Amarkantak, 1999.

13. Human Values, A.N. Tripathi, New Age Intl. Publishers, New Delhi

14. Rediscovering India ‐ by Dharampal

15. Hind Swaraj or Indian Home Rule ‐ by Mohandas K. Gandhi

16. India Wins Freedom ‐ Maulana Abdul Kalam Azad

17. Ramakrishna kijeevani ‐ Romain Rolland (English)

18. Vivekananda ‐ Romain Rolland (English)

19. Gandhi ‐ Romain Rolland (English)

20. Autobiography of a Yogi – by Paramhansa Yogananda

21. Gandhi and Question of Science – Sahasrabudhe


At the end of the course, students are expected to become more aware of their self and their

relationships and would have better reflective and discerning ability. They would also become

more sensitive to their surroundings including both people and nature, with commitment

towards what they believe in (human values). It is hoped that they would be able to apply

what they have learnt to their own self in different ordinary day‐to‐day settings in real life

with higher commitment and courage.

SEMESTER 2 COMPUTER PROGRAMMING

1. GENERAL

1.1. COURSE TITLE: COMPUTER PROGRAMMING

1.2. *COURSE CODE: IE.CSO101.14


1.4. CREDITS: 13


1.6. SYLLABUS OF COMMITTEE MEMBERS: Prof. S.K. Pandey (Convener), Dr. Rajeev

Srivastava, Dr. Ravi Shankar Singh, Prof. L.P. Singh, Prof. S. Mukhapadhyay, Dr. Subir Das, Prof.

B.N. Sharma, Prof. R.K. Mishra, Dr. P. Ghosh


2. OBJECTIVE

1. To introduce problem solving methods and algorithm development.

2. To teach programming language C.

3. To teach how to design, code, debug and document programs using techniques of good

programming style.

3. COURSE CONTENTS

Unit I: (10 Lectures)

Programming Language C and programming: Basic Syntax and Semantics, Variables, Types,

Expressions, Assignment statements, Conditional and Iterative Control Structures.

Unit II: (10 Lectures)

Simple I/O, Functions and parameter passing, Strings and string processing, Pointers and

References, Structures, Recursion.

Unit III: (19 Lectures)

Algorithm development: Techniques of problem solving, Stepwise Refinement, Simple

numerical examples, algorithms for searching and sorting, merging order lists. Examples taken

from such areas as business applications involving data manipulation, and simulation

involving games.


1. Analyze and explain the behaviour of simple programs involving the fundamental

programming constructs. 2. Modify and expand short programs that use standard conditional

and iterative controls structures and functions. 3. Design, implement, test and debug a

program that uses each of fundamental programming constructs. 4. Apply the technique of

structured decomposition to break a program into smaller pieces.

ENGINEERING MATHEMATICS – I

1. GENERAL

1.1. COURSE TITLE: ENGINEERING MATHEMATICS ‐ I

1.2. *COURSE CODE: IS.MA101.14


1.4. CREDITS: 11


1.6. SYLLABUS COMMITTEE MEMBERS: Prof. T. Som (Convener), Dr. V.K. Singh

2. COURSE CONTENTS

Unit I: Sequences and Continuous Functions (10 Lectures)

Real number system: Completeness axiom, density of rationals (irrationals) in R, Convergence

of a sequence, Sandwich theorem, Monotone sequences. Limits and Continuity of functions,

Intermediate value property, Differentiability, Necessary condition for local maxima, Rolle's

theorem and Mean value theorem, Cauchy mean value theorem, L' Hospital rule, Increasing

and decreasing functions, Convexity, Second derivative test formax and min, Point of

inflection, curve sketching.

Unit II: Power Series Expansions (4 Lectures)


Taylor's theorem with remainder, Convergence of series, Absolute convergence,

Comparison test, Ratio test, Root test, Power series, Radius of convergence, Taylor series,

Maclaurin series.

Unit III: Riemann Integration, Surface Area & Volume (7 Lectures)

Introduction to Riemann integration, Elementary properties of integral, Fundamental

Theorems of calculus, Improper integral of first & second kind, Comparison test, Absolute

convergence, Applications of definite integral: Polarcoordinates, Graphs in polar coordinates,

Area between two curves when their equations are given in polar coordinates, Volumes by

slicing, Length of a curve.

Unit IV: Multi‐variable Calculus (6 Lectures)

Functions of several variables, Continuity, Partial derivatives, Total derivative, Increment

theorem, Chain rule, Gradient, Directional derivatives, Tangent plane and Normal line, Mixed

derivative theorem, Necessary and sufficient conditions for Maxima, Minima and Saddle

point, The method of Lagrange multipliers.

Unit V: Vector Calculus (4 Lectures)

Review of vector algebra, Equations of lines and planes, Continuity and Differentiability of

vector functions, Arc length for space curves, Unit tangent vector, Unit normal and Curvature

to plane and space curves,

Unit VI: Multiple Integrals (8 Lectures)

Double integral, Fubini's theorem, Volumes and Areas, Change of variable in a double

integral, special case: Polar coordinates,Triple integral, Applications, Change of variables in a

triple integral, Surface area, Surface area (contd.), Line integrals, Surface integrals, Green's

Theorem, Vector fields, Divergence and Curl of a vector field, Stokes' Theorem, The

divergence theorem.

3. READINGS

3.1 TEXTBOOK:

Calculus by Thomas and Finney.

ESSENTIALS OF BIOCHEMISTRY

1. GENERAL

1.1. COURSE TITLE: ESSENTIALS OF BIOCHEMISTRY

1.2. COURSE CODE: IS.CY103.14


1.4. CREDITS: 11

1.5. SEMESTER OFFERED: Semester II

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. Senthil Raja A (Convener), Dr. Ranjana Patnaik

(Member), Dr. Sanjeev K Mahto (Member)

2. OBJECTIVE

The course aims to provide an understanding of the core principles and topics of biochemistry

and their experimental basis, and to enable students to acquire a specialized/research level

knowledge and understanding of advanced topics in biochemical, biomedical and

pharmaceutical sciences.


3. COURSE CONTENTS

Unit I: Scope and importance of Biochemistry: Overview of metabolic pathways, biochemical

basis of diseases, significance biochemistry in drug discovery. (2 Lectures)

Unit II: Bioenergetics: Energetics of cellular reactions, biological redox reactions, oxidative

phosphorylation and ATP synthesis. (4 Lectures)

Unit III: Vitamins: Structure and biochemical functions of water soluble vitamins, coenzymes. (3

Lectures)

Unit IV: Carbohydrates: Glycolysis, glycogenolysis, glycogenesis, gluconeogenesis, Krebs cycle,

HMP Shunt, regulation of carbohydrate metabolism. (4 Lectures)

Unit V: Amino acids: Classification, metabolism of non‐essential amino acids, urea cycle. (4

Lectures)

Unit VI: Lipids: Classification of lipids and fatty acids, metabolism, regulatory mechanisms and

biochemical importance of fatty acids and cholesterol. (5 Lectures)

Unit VII: Proteins: Primary, secondary, tertiary and quaternary structures, types and functions,

biosynthesis. Methods of purification including centrifugation, chromatographic and

electrophoretic methods. (5 Lectures)

Unit VIII: Nucleic acids: Structure, functions of DNA and RNA. DNA replication. Methods of

characterization of DNA and RNA. (4 Lectures)

Unit IX: Enzymes: Classification, mechanism of action, kinetic derivation of Michaelis Menten’s

equation, regulatory enzymes ‐ allosteric and feedback inhibition. (4 Lectures)

Unit X. Hormones: Classification, mechanism of actions of insulin, glucagon, epinephrine and

cortisol. Hormonal regulation of fuel metabolism. (4 Lectures)

4. READINGS

4.1. Reference Books

1. Harper's Illustrated Biochemistry, 26th Edition, Robert Murray, Victor Rodwell, David

Bender, Kathleen M. Botham, P. Anthony Weil, Peter J. Kennelly. Publisher: McGraw Hill

Professional.

2. Lehninger Principles of Biochemistry, Fourth Edition by David L. Nelson, Michael M. Cox,

Publisher: W. H. Freeman


At the end of the course the student should be able to:

a) demonstrate integrated knowledge and understanding in the listed core topics and the

impact of vital biochemical processes in the progression and manifestation of a disease.

b) acquire and build advanced knowledge and understanding in specialized areas like

bioinformatics, pharmacology and drug design and discovery.

c) analyse the research literatures of biochemistry topics and able to present them.

BASIC PHARMACEUTICAL SCIENCES

1. GENERAL

1.1. COURSE TITLE: BASIC PHARMACEUTICAL SCIENCES

1.2. *COURSE CODE (if known): EP/DC.PH101.14



1.4. CREDITS: 11

1.5. SEMESTER OFFERED: II Semester

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. A.N.Sahu (Convener), Dr. Senthil Raja A, Dr. Ruchi

Chawla

2. OBJECTIVE

The objectives of this foundation course include; (a) to introduce the fundamental concepts

and practices of pharmaceutical sciences and technology; (b) to provide practical exposure of

basic laboratory techniques of pharmaceutics, pharmaceutical chemistry and pharmacognosy.

3. COURSE CONTENTS

Unit I: History and scope of Pharmacy

Concept of Pharmaceutical dosage forms‐ Classification of dosage forms‐Conventional and

Novel, Routes of administration, General evaluation techniques for dosage forms

Unit II: Basics and applications of unit operations

Unit III: Terms and terminologies of pharmaceutical sciences and technology. Introduction to

pharmaceutical chemistry and pharmaceutical analysis. (2L)

Unit IV: Sources of drugs and pharmaceuticals, general nomenclature of drugs, general profile

of selected drugs of inorganic, organic, biological and natural origins. (4L)

Unit V: Introduction to Pharmacopoeia (IP, BP, USP, etc), Monograph I.P. Monographs of

selected drugs of inorganic, organic, biological and natural origins. (3L)

Unit VI: Quality control in pharmaceuticals, Sources of impurities and their pharmacopoeial

limits, Limit tests. (4L)

Unit VII: Introduction to plant drugs, classification and significance. (2L)

Unit VIII: Introduction to plant derived drugs and excipients. (2L)

Unit IX. Production of crude drugs: Cultivation, Collection, Drying and Storage (3L)

Unit X. Preliminary study of phytochemicals in crude drugs and their identification. (2L)

Unit XI: Extraction methods for phytochemicals: Maceration, percolation, volatile oil

extraction. (4L)

LABORATORY:

Techniques for milling, mixing, drying and size reduction

Preparation and evaluation of liquid dosage forms IP

Preparation and evaluation of solid / semi‐solid dosage forms IP

Basic operations in pharmaceutical chemistry laboratory (1P)

Limit test of anionic (chloride and sulphate) impurities IP (2P)

Limit test of cationic (iron) impurities IP (1P)

Preparation and standardization of an inorganic drug (2P)

Preparation and standardization of an organic drug (2P)

Isolation of starch

Isolation of one major phytoconstituent

Isolation of volatile oil

4. READINGS

4.1 TEXTBOOK:


1. Atherden, L.M.Bentley and Driver's Textbook of Pharmaceutical Chemistry.

2. Pandeya, S.N., A Textbook of Inorganic Pharmaceutical Chemistry, First Edition, 2006.


1. Indian Pharmacopoeia, 1996, Vol I & Volume II.

2. Evans WC, Trease and Evans – Pharmacognosy, 15th edn., WB Saunders, London, 2002.

3. Wallis TE, Textbook of Pharmacognosy, 5th edn., CBS Publishers and Distributors, New Delhi

4. Handa SS, Khanuja SPS, Longo G and Rakesh DD, Extraction Technologies for Medicinal and

Aromatic Plants, 1st edn., International Centre For Science And High Technology, Trieste, 2008


The students would know and understand the basic principles of various streams namely

pharmaceutics, pharmaceutical chemistry, Pharmacognosy, pharmaceutical analysis, etc., of

pharmacy discipline. This course would help them in choosing an appropriate area for their

exploratory project during the second year and also selecting the right bouquet of courses of

their interest in the third and fourth year levels.

DEVELOPMENT OF SOCIETIES (To be included)

HISTORY & CIVILIZATION (To be included)

PHILOSOPHY (To be included)

EDUCATION & SELF (To be included)

SEMESTER 3 FLUID MECHANICS

1. GENERAL

1.1. COURSE TITLE: FLUID MECHANICS

1.2. *COURSE CODE: IE.CHO102.14


1.4. CREDITS: 11

1.5. *SEMESTER OFFERED: I/II Semester

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. R S Singh (Convener), Shri A C Mohan, (CH), Dr. P.

Shukla

2. OBJECTIVE

This is a core subject, basic knowledge of which is required by all the engineers in general and

civil, mechanical and chemical engineers in particular. This course aims at developing an

understanding of the behaviour of fluids in motion or at rest and the subsequent effects of

the fluids on the boundaries. The study of this subject will develop analytical abilities related

to fluid flow.

3. COURSE CONTENTS


Unit I: Fluid Properties and Fluid Statics: Concept of fluid and flow, ideal and real fluids,

continuum concept, properties of fluids, Newtonian and non‐Newtonian fluids. Pascal’s law,

hydrostatic equation, hydrostatic forces on plane and curved surfaces, stability of floating and

submerged bodies, relative equilibrium. (05)

Unit II: Fluid Kinematics: Eulerian and Lagrangian description of fluid flow; stream, streak and

path lines; types of flows, flow rate and continuity equation, differential equation of

continuity in cylindrical and polar coordinates, rotation, vorticity and circulation, potential

flow, stream and potential functions, flow net. (06)

Unit III: Fluid Dynamics: Concept of system and control volume, Euler’s equation, Bernoulli’s

equation, kinetic and momentum correction factors, Impulse momentum relationship and its

applications. (06)

Unit IV: Dimensional Analysis and Hydraulic Similitude: Dimensional analysis, Buckingham’s Pi

theorem, important dimensionless numbers and their significance, geometric, kinematics and

dynamic similarity, model studies. (04)

Unit V: Viscous Flow: Flow regimes and Reynold’s number, Relationship between shear stress

and pressure gradient, uni‐directional flow between stationary and moving parallel plates.

(04)

Unit VI: Flow Through Pipes: Major and minor losses in pipes, Hagen‐Poiseuilli law, hydraulic

gradient and total energy lines, series and parallel connection of pipes, branched pipes;

equivalent pipe, power transmission through pipes, pipe fittings and valves. (06)

Unit VII: Boundary Layer Flow: Boundary layer concept, displacement, momentum and energy

thickness, laminar and turbulent boundary layer flows, Drag force and drag coefficient ,drag

on a flat plate, boundary layer separation and control. Streamlined and bluff bodies, lift and

drag on a cylinder and an airfoil. (06)

Unit VIII: Turbulent Flow: Shear stress in turbulent flow, Prandtl mixing length hypothesis,

hydraulically smooth and rough pipes, velocity distribution in pipes, friction coefficients for

smooth and rough pipes. (05)

UNIT IX: Flow Measurement: Manometers, pitot tubes, venturi meter and orifice meters,

orifice, mouthpieces, Open channel flow, notches and weirs, rotameter, mass flow meter and

hot‐wire anemometer. (05)

UNIT X: Working principles, characteristics, selection and power requirements in mixing of

fluids, pumps, blowers and compressors. (05)

4. READINGS

4.1 TEXTBOOK

1. Introduction to Fluid Mechanics, Fox & Mcdonald, John & Wiley

2. McCabe, W.L., Smith J.C., and Harriot, P., “Unit Operations in Chemical Engineering”,

McGraw‐Hill, Inc.

3. Fluid Mechanics – Streeter V L and Wylie E B, Mc Graw Hill

4. Coulson, J.M. and Richardson, J.F., “Chemical Engineering, Volume I”, Pergamon Press.

5. Fluid Mechanics Frank M. White 7th edition Mcgraw‐Hill

4.2 *REFERENCE BOOKS

1. Geankoplis, C.J., “Transport Processes and Unit Operations”, Prentice‐Hall Inc.


2. Introduction to Fluid Mechanics and Fluid Machines – S.K. Som and G. Biswas, TMH

5. OUTCOME OF THE COURSE:

1. Conceptual understanding of fluids and their properties.

2. Understanding of fluid statistics, fluid kinematics and fluid dynamics.

3. Basic knowledge of dimensional analysis and similitude.

4. Understanding of laminar and turbulent flows, and flow measurement.

PROBABILITY AND STATISTICS

1. GENERAL

1.1. COURSE TITLE: PROBABILITY AND STATISTICS

1.2. *COURSE CODE: IS.MA202.14


1.4. CREDITS: 11


1.6. PREREQUISITE: Mathematics I

1.7. SYLLABUS OF COMMITTEE MEMBERS: Dr. Subir Das (Convener), Dr. Anuradha Banerjee

2. COURSE CONTENTS

Unit I: Probability (4 Lectures)

Classical, Relative Frequency and Axiomatic definitions, Properties of Probability Function,

Conditional Probability, Independence of Events, Theorem of Total Probability, Bayes’

Theorem.

Unit II: Random Variable and Its Distribution (4 Lectures)

Definition of Random Variable, Distribution Function and Its Properties, Types of Probability

Distributions (Discrete, Continuous, Absolutely Continuous and Mixed Type), Probability Mass

Function, Probability Density Function, Mathematical Expectation, Moments, Probability and

Moment Generating Functions and Their Properties, Characteristics of Probability

Distributions (Measures of Central Tendency, Measures of Skewness and Kurtosis), Markov

and Chebychev Inequality.

Unit III: Special Discrete Distributions (2 Lectures)

Bernoulli and Binomial Distribution, Geometric and Negative Binomial Distribution, Hyper‐

Geometric Distribution, Poisson Distribution, Discrete Uniform Distribution.

Unit IV: Special Absolutely Continuous Distributions (3 Lectures)

Uniform Distribution, Exponential and Gamma Distributions, Beta Distribution, Cauchy

Distribution and Its Moments, Normal Distribution and Its Properties.

Unit V: Function of Random Variables and Its Distribution (3 Lectures)

Function of Random Variable, Methods to Find Distribution of Function of a random Variable

(Distribution Function, Jacobian and M.G.F Methods) and Their Expectations.

Unit VI: Random Vector and Its Joint Distribution (4 Lectures)

Definition of Random Vector, Distribution Function of a Random Vector and Its Properties,

Joint, Marginal and Conditional Distributions, Product Moments, Covariance and Correlation,

Joint Moment Generating Function and Its Properties, Multinomial Distribution, Bivariate

Normal Distribution.


Unit VII: Function of Random Vector and Its Distribution (4 Lectures)

Function of Random Vectors, Methods to Find Distribution of Function of a Random Variable

(Distribution Function, Jacobian and M.G.F Methods) and Their Expectations. Distribution of

Order Statistics.

Unit VIII: Sampling Distributions and Asymptotic Distributions (3 Lectures)

Joint Distribution of Sample Mean and Sample Variance Based on a Random Sample From

Normal Distribution, Chi‐Squared, Student’s t and Snedcor’s F‐Distributions and Their Relation

to Normal Distribution, Weak Law of Large Numbers, Central Limit Theorem.

Unit IX: Statistics (1 Lectures)

Introduction to Statistical Inference Problems, Random Sample, Statistic, Population,

Parameters.

Unit X: Point Estimation (3 Lectures)

Point estimation problems, Method of Moments; Method of Maximum Likelihood, Invariance

of Maximum Likelihood Estimators, Unbiased Estimators, Consistent Estimators, Criteria for

Comparing Estimators.

Unit XI: Interval Estimation (3 Lectures)

Interval Estimation Problems, Confidence Intervals, Confidence intervals for normal

population(s): mean, difference of means, variance and ratio of variance, Confidence intervals

for proportion and difference of proportions.

Unit XII: Testing of Hypotheses (6 Lectures)

Null and Alternative Hypotheses, Simple and Composite Hypotheses, Critical Regions,

Neyman‐Pearson lemma, Most Powerful and Uniformly Most powerful Tests and their

Examples, p‐value, Likelihood ratio tests; Likelihood ratio tests for Statistical Hypotheses in

One and Two Sample Problems Involving Normal Populations, Tests for Proportions, Chi‐

Square Goodness of Fit Test, Contingency Tables.

3. READING


HUMAN PHYSIOLOGY

1. GENERAL

1.1. COURSE TITLE: HUMAN PHYSIOLOGY

1.2. *COURSE CODE: MC.BO202.15


1.4. CREDITS: 09

1.5. SEMESTER OFFERED: Sem. III

1.6. PRE‐REQUISITES: Nil

1.7. Syllabus of Committee Member: Dr. A.K.Ray (Convener), Dr. Vikas Kumar, Dr. K. Sairam

2. OBJECTIVE

The course is designed for the students to acquire knowledge regarding the structure and

functions of the organ‐systems of our own body.

3. COURSE CONTENTS


Unit I. Introduction to Human Physiology (1 lecture)

Unit II. Hematology: Blood composition and function. Structure and function of red blood

cells, white blood cells and platelets. Blood transfusion. Hemostasis. Immune mechanisms.

(4 lectures)

Unit III. Circulatory and Lymphatic System: Anatomy of the heart and the blood vessels.

Heart‐position and function. Origin of the heart beat and electrical activity of the heart.

Arteries, capillaries and veins‐ structure and function. Cardiac and peripheral circulation.

Blood pressure and its regulation. Blood flow and its regulation. Circulatory shock. Lymph and

dynamics of lymph flow. (5 lectures)

Unit IV. Respiratory system: Anatomical parts of the system and function. Mechanics of

respiration. Lung volumes and capacities. Gas transport between the lungs and tissues.

Regulation of respiration. Respiratory adjustments in health and diseases. (5 lectures)

Unit V. Digestive system: Different parts of the digestive system. Structure and function of

these organs. Digestion of proteins, carbohydrates, fats. Basic mechanism of gastrointestinal

absorption of nutrients. (3 lectures)

Unit VI. Endocrine system and Reproductive system: Elementary knowledge of structure and

function of ndocrine glands. Functions of male reproductive organs, female reproductive

organs & contraception. (5 lectures)

Unit VII. Musculo-skeletal System: Different types of muscles and their characteristics.

Neuro‐muscular transmission. Structure of bone. General description of joints and structure.

Disorders of: neuro‐muscular apparatus and joints. (4 lectures)

Unit VIII. Urinary system: Various parts, structure and functions of the kidney and urinary

tract. Physiology of urine formation and acid base balance. Diseases of the urinary system

with reference to drugs used. (4 lectures)

Unit XI. Autonomic Nervous System: Physiology and functions of the autonomic nervous

system. Mechanism of Neurohumoral transmission in ANS. (4 lectures)

Unit X. Central Nervous System: Functions of different parts of brain and spinal card.

Neurohumoral transmission in the central nervous system, reflex action,

electroencephalogram, specialized functions of the brain, cranial nerves and their functions.

(5 lectures)

4. READINGS

4.1 TEXTBOOK: 1. Text Book of Medical Physiology, Guyton & Hall, W.B. Saunders company.

Hardcourt India Private Limited

2. Ganongs Review of Medical Physiology. K E Barrett, S M Barman, S Boitano, H L Brooks,

Tata McGraw Hill Education Private Limited.

3. Human Physiology, C C Chatterji


Vander’s Human Physiology: The Mechanisms of Body Function. Eric P. Widmaier, Hershel

Raff, Kevin T. Strang. McGraw Hill

Ross and Wilson Anatomy and Physiology in Health and Illness by Anne Waugh, Elsevier



At the end of the course students will be able to apply the knowledge of human systems to

the different areas of Bioengineering and Medicine.

PHYSICAL PHARMACEUTICS

1. GENERAL

1.1. COURSE TITLE: PHYSICAL PHARMACEUTICS

1.2. COURSE CODE: DC.PH211.15


1.4. CREDITS: 9

1.5. SEMESTER OFFERED: 3rd

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. B.Mishra, Mr. A.K. Srivastava, Ms. Ruchi Chawa

(Convener)

2. OBJECTIVE

The course aims to provide an understanding of the core principles and topics of physical

pharmaceutics and their experimental basis, and to enable students to acquire a

basic/fundamental level understanding of the aspects of factors affecting the properties of

the pharmaceutical dosage forms.

3. COURSE CONTENTS

Unit I. Scope and understanding of physical pharmaceutics: Overview of formulation stability

in relation to various physical and chemical parameters (2 Lectures)

Unit II. Rheology ‐ Newtonian and non‐Newtonian systems, measurement of thixotropy, types

of viscometers, application of rheology in dosage form development. (4 Lectures)

Unit III. Rate and Kinetics: Zero order, first order, second order and mixed order reactions,

half life, determination of order, influence of temperature and other factors on reaction rate.

(4 Lectures)

Unit IV. Stability studies: Long term, intermediate and accelerated stability studies, prediction

of shelf life, stabilization of dosage forms. (2 Lectures)

Unit V. Complexation: types of complexes, applications in pharmaceutics (3 Lectures)

Unit VI. Protein binding: effect of protein binding on bioavailability, pharmaceutical and

medicinal applications. (3 Lectures)

Unit VII. Solubility and Distribution Phenomena: factors effecting solubility, methods of

determination of solubility and methods of improvement of solubility, Applications in

Pharmacy. (4 Lectures)

Unit VIII. Micromeritics: Methods of sub‐division of drugs/pharmaceuticals, Sieves, Standards

of sieves, Grading of powders, determination of particle size; Importance of particle size

distribution, Applications in Pharmacy. (4 Lectures)

*LABORATORY: 3 hrs/week

Qualitative and quantitative observation of physical parameters of pharmaceutical

formulations.

Introduction to granulation and particle size analysis.

Observation of Rheological properties of pharmaceutical formulations: suspensions,

emulsions, pastes, gel, etc.


Stability studies

Determination of moisture contents in granules/ herbal drugs and drug products

4. READINGS

4.1. Reference Books:

J.A.Kitckener, Findley’s Physical Chemistry, Green & Co., London.

D.P.Shoemaker, C.W.Garland, Experiments in Physical Chemistry, McGraw Hill Book Co., New

York.

A.N.Martin: Physical Pharmacy, Lippincott Williams and Wilkins, Baltimore, USA.



demonstrate integrated knowledge and understanding of the vital physical processes and

their impact on the properties of pharmaceutical formulations.

acquire and build advanced knowledge and understanding in specialised areas like

biopharmaceutics, pharmacology and dosage formulation design.

PHARMACEUTICAL CHEMISTRY

1. GENERAL

1.1. COURSE TITLE: PHARMACEUTICAL CHEMISTRY



1.4. CREDITS: 9


1.6. SYLLABUS COMMITTEE MEMBERS: Dr. Senthil Raja A (Convener), Dr. Ashok Kumar

2. OBJECTIVE

The course aims to provide an understanding of the basic topics of pharmaceutical chemistry

including inorganic and organic compounds of pharmaceutical importance and to enable the

students to acquire the theoretical and practical knowledge of basic organic synthetic

reactions and mechanisms.

3. COURSE CONTENTS

Unit I. Inorganics: A systemic study including methods of preparation, properties, tests for

identity & purity, assay and uses of inorganic drugs belonging to the following categories:

Anti‐infectives, Antacids, Astringents, Dentrifices, Electrolyte replenishers, Haematonics,

Pharmaceutical aids, Protectives, etc. (5L)

Unit II. Radiopharmaceuticals: Introduction, classification, preparation, properties, diagnostic

and therapeutic applications of radioisotopes. (2L)

Unit III. Organics: Classification of aliphatics, carbocyclics, polycyclics and heterocyclics,

Nomenclature of compounds and drugs belonging to above categories. (1L)

Unit IV. Stereochemistry: Classification of isomers, chirality and its importance in pharmacy,

configurations of compounds with multiple chiral centers, Stereochemistry of alicyclic

compounds, conjugated dienes, steroids etc. (3L)

Unit V. Study of following naming reactions including their synthetic applications: Cannizzaro,

Perkin, Reimer‐Tieman, Meerwein‐Pondorf verley, Friedal Crafts, Reformatsky, Mannich,


Michael, Witting, Fries rearrangement, Diels‐Alder, Sandmeyer, Beckmann, Claisen

condensation etc. (4L)

Unit VI. Carboxylic acids: Preparation, properties and their Pharmaceutical importance of

linear dicarboxylic acids and tricarboxylic acids and hydroxy acids. Preparation and synthetic

application of compounds containing reactive methylene group: malonic ester, acetoacetic

ester and cyano ester. (4L)

Unit VII. Benzene and its derivatives: Structure and stability of benzene. Chemistry of

benzene, alkyl benzenes, halobenzenes, aniline, phenol, benzene sulphonic acid, etc. Study of

occurence, structure, category and indications of drugs belonging to above classes. (4L)

Unit VIII. Chemistry of polynuclear hydrocarbons and their derivatives: Naphthalene,

Anthracene and Phenanthrene. Study of occurence, structure, category and indications of

drugs belonging to above classes. (3L)

LABORATORY

1. Identification of unknown inorganic mixtures of anions and cations – 5 turns

2. Identification of unknown organic compound – 5 turns

3. Single step preparation and identification of organic compounds – 3 turns

4. READINGS

I.L. Finar, Organic Chemistry, The Fundamental Principles, ELBS/Longman. Vol 1. 4th edition.

1963.

L M Atherden, Bentley and Driver's Textbook of Pharmaceutical Chemistry, 1969.


Students will know the applications of common principles of inorganic and organic chemistry

in pharmacy. Students will be familiar with at least fifty inorganic and fifty organic drugs and

the methods of preparation and identification of those drugs.

SEMESTER 4

HEAT AND MASS TRANSFER

1. GENERAL

1.1. COURSE TITLE: HEAT AND MASS TRANSFER

1.2. *COURSE CODE: IE.CMO103.14


1.4. CREDITS: 11

1.5. *SEMESTER OFFERED: Even

1.6. PREREQUISITE: Fluid Mechanics

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. M.K. Mondal (CH) (Convener), Prof. K.K. Srivastava,

Dr. P. Ghosh, Dr. J. Sirkar, Dr. S.S. Mondal, Dr. B. Eshpuniyani (ME)

2. OBJECTIVE

Various modes of heat Transfer and introduction to diffusional Mass Transfer

3. COURSE CONTENTS

Unit I: INTRODUCTION TO HEAT TRANSFER (3 Lectures)


Basic concepts, Various modes of heat transfer, Fourier`s, Newton`s and Stefan Boltzmann’s

law, thermal diffusivity, overall heat transfer coefficient.

Unit II: CONDUCTION (9 Lectures)

The thermal conductivity of solids, liquids and gases, Differential equation of heat

conduction, boundary and initial conditions, one dimensional steady state heat conduction,

conduction through plane wall, cylinders, spherical and composite systems, conduction with

Internal heat Generation, critical thickness of insulation, heat transfer from fins, conjugate

Heat Transfer, Unsteady state heat conduction‐ lumped analysis, Use of Heislers Chart.

Unit III: FORCED CONVECTION (6 Lectures)

Fundamentals, laminar boundary layer equations on a flat plate and in a circular pipe, heat

transfer in laminar flow and turbulent flow over a flat plate, circular pipe etc, analogy

between heat and momentum transfer, Dimensional analysis of forced convection.

Unit IV: NATURAL CONVECTION (4 Lectures)

Introduction, Dimensional analysis of natural convection, governing equations for natural

convection, convection with phase change, boiling heat transfer.

Unit V: HEAT EXCHANGERS (4 Lectures)

Different types of heat exchangers, LMTD and NTU approach, Heat exchanger transfer units,

Analysis restricted to parallel and counter and cross flow heat exchange.

Unit VI: RADIATION (5 Lectures)

Introduction, radioactive properties of opaque surfaces, Plank`s law, Wien`s displacement

law, Black and Gray surfaces, Emissivity, absorptivity, Spectral and directional variations,

Stephan Boltzmann law, Kirchhoff`s law, Radiation exchange between black surfaces, Shape

factor, Electrical analogy to simple problems, Non‐luminous gas radiation.

Unit VII: INTRODUCTION TO MASS TRANSFER (3 Lectures)

Basic Concepts, Classification of mass transfer operations, Concentration, velocity and flux,

Fick’s law, molecular diffusion in gases, liquids, and solids, Application of molecular

diffusion.

Unit VIII: MASS TRANSFER COEFFICIENT & CONVECTIVE MASS TRANSFER (4 Lectures)

Mass transfer coefficients, Turbulent or Eddy diffusion, Dimensionless groups in mass

transfer, Correlations for convective mass transfer coefficient, Analogy between mass and

momentum transfer, Mass transfer equipments‐ Packed column, plate column, spray

column, etc.

Unit IX: COMBINED HEAT AND MASS TRANSFER (4 Lectures)

Humidification and dehumidification, Wet and dry bulb hygrometry, Theory and mechanism

of drying, drying rates, Different dryers and their design principles.

4. READINGS

4.1 TEXTBOOK:

1. Holman, J.P., "Heat Transfer", Tata McGraw Hill Book Company, 1988.

2. Fundamental of Heat and Mass Transfer, Frank P. Incropera, David P. DeWitt, Theodore L.

Bergman, Adrienne S. Lavine, John Willey, 2009


3. Sachdeva, KC, "Fundamentals of Engineering Heat and Mass Transfer", New Age

International Publishers, New Delhi, 1996.

4. Kothandaraman, CP., "Fundamentals of Heat and Mass Transfer", Second Edition, New

Age International Publishers, Chennai, 1997.


Students will gain knowledge on brief overview of the subject.

BIOORGANIC AND MEDICINAL CHEMISTRY

1. GENERAL

1.1. COURSE TITLE: BIORGANIC AND MEDICINAL CHEMISTRY



1.4. CREDITS: 11


1.6. PREREQUISITES: Pharmaceutical Chemistry

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. Senthil Raja A (Convener), Dr. S.K. Shrivastava

(Member), Dr. Ashok Kumar (Member)

2. OBJECTIVE

The course aims to provide an understanding of the basic topics of bioorganic and medicinal

chemistry including heterocyclic and natural compounds of pharmaceutical importance and to

enable the students to acquire the theoretical and practical knowledge of relevant organic

synthetic reactions and mechanisms.

3. COURSE CONTENTS

Unit I. Heterocyclic Chemistry: Introduction, Classification and Nomenclature of heterocyclic

compounds. (1 Lecture)

Study of synthesis, reactions and medicinal derivatives including recent drugs (Structure and

mode of action & uses) belonging to the following heterocyclic systems:

Unit II. One hetero atom in five and six membered ring: Pyrrole, furan, thiophene, pyridine. (3

Lectures)

Unit III. Two hetero atoms in five and six membered ring: Pyrazole, Imidazole, Thiazole,

Oxazole, Pyrimidine, Piperazine. (5 Lectures)

Unit IV. Five or six membered heterocyclics fused to one Benzene ring: Indole, Benzimidazole,

Benzoxazole, Benzthiazole, Quinoline, Isoquinoline, Quinazoline. (6 Lectures)

Unit V. Benzodiazepine, phenothiazines, acridines, dibenzazepins. (4 Lectures)

Unit VI. Chemistry of Purine and Pyrimidines derivatives: Xanthenes, Guanine, Uric acid and

their pharmaceutical importance. (3 Lectures)

Unit VII. Chemistry of Carbohydrates: structure and ring‐size of glucose and fructose,

synthesis of aldohexoses from glyceraldehyde and the pharmaceutical importance of the

carbohydrates. (3 Lectures)

Unit VIII. Chemistry of fats and oils and their pharmaceutical importance. (2 Lectures)

LABORATORY

Two‐step synthesis of organic/heterocyclic compounds/drugs – 5 turn


Identification of carbohydrates/drugs – 5 turns

Estimation of oils – 3 turns

4. READINGS

T. L. Gilchrist, "Heterocyclic Chemsitry", Wiley‐VCH, Weinheim 1995

A. R. Katritzky, A. F. Pozharskii "Handbook of Heterocyclic Chemistry", 2nd ed., Pergamon,

Oxford 2000,

S N Pandeya, Textbook of Medicinal Chemistry (Synthetic & Biochemical Approach) Vol I & II


Students will know the applications of common principles of heterocyclic/medicinal chemistry

in pharmacy. Students will be familiar with at least fifty heterocyclic drugs and the methods of

preparation and identification of those drugs.

GENERAL PHARMACOLOGY

1. GENERAL

1.1. COURSE TITLE: GENERAL PHARMACOLOGY



1.4. CREDITS: 11

1.5. SEMESTER OFFERED: 4th

1.6. PREREQUISITES: Biology, Essentials of Biochemistry, Human Physiology

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. Sairam Krishnamurthy (Convener), Dr. Sanjay Singh

Dr. Vikas Kumar

2. OBJECTIVE:

The central goal of course is to provide students with a basic understanding of drug actions in

order to assure appropriate clinical utilization of pharmacological agents and solid grounding

in the basic concepts and scientific substructure of Pharmacology. Also provide students with

a comprehensive introduction to the fundamental Pharmacology and uses of the major

classes of clinically important drugs currently used in medical practice.

3. COURSE CONTENTS

Unit I. Definition, scope and branches of pharmacology. Historical development with special

reference to India. (4 Lectures)

Unit II. Routes of drugs administration and drug delivery systems. (2 Lectures)

Unit III. Dynamics of absorption, distribution, metabolism and excreation of drugs. (3

Lectures)

Unit IV. Basic pharmacokinetic parameters employed in the use of drugs, their bioavailability

and biotransformation, metabolizing enzymes as targets of drugs action (induction and

inhibition). (3 Lectures)

Unit V. Mechanisms of drugs action, drug receptors and cellular signaling systems. (5

Lectures)

Unit VI. Drug antagonism and synergism. (5 Lectures)

Unit VII. Drug dependence and related conditions. (4 Lectures)

Unit VIII. Adverse drug effects and their monitoring, iatrogenic diseases. (4 Lectures)


Unit IX. Pharmacogenomics and Pharmacogenetics. (5 Lectures)

Unit X. Bioassays: General principles and methods of Bioassays. (4 Lectures)

*LABORATORY

1. To draw and label various instruments used in Pharmacology Lab. (2 hours)

2. To estimate the bleeding time and clotting time of own blood.(2 hours)

3. To estimate the haemoglobin count in own blood. (2 hours)

4. To study the anatomy of compound microscope. (2 hours)

5. To determine WBC count of own blood. (2 hours)

6. To determine RBC count of own blood. (2 hours)

7. To draw and label different anatomical parts of the brain. (2 hours)

8. To study the anatomy of the Limbic system. (2 hours)

9. To study Anatomy and Physiology of Basal Ganglia. (2 hours)

10. To study the Anatomy of Ventricle and Blood Vessels. (2 hours)

11. To study Anatomy and Physiology of Spinal Cord. (2 hours)

12. To study the Anatomy of the Eye. (2 hours)

13. To measure the blood pressure. (2 hours)

4. READINGS


1. Goodman and Gilman's: The Pharmacological Basis of Therapeutics 6 edition, Alfred

Goodman Gilman, Theodore W.Rall, Alan Nies, Palmer Taylor, Publisher: Macmillan Publishing

Company.

2. Rang & Dale's Pharmacology 7 edition, Humphrey P. Rang, Maureen M. Dale, James M.

Ritter, Rod J. Flower, Graeme Henderson, Publisher: Churchill Livingstone.

3. Clinical Pharmacology 8 edition, D.R. Laurence, P.N.Bennett, Morris J. Brown, Publisher:

Churchill Livingstone.

4. Essentials of Medical Pharmacology 7 edition, K.D.Tripathi, Publisher: Jaypee Brothers

Medical Publishers (P) Ltd.

5. Pharmacology and Pharmacotherapeuties 22 edition, R.S.Satoskar, Nirmala B. Rege,

S.D.Bhandarkar, Publisher: Popular Prakashan.

6. Essentials of Pharmacotherapeuties New edition, F.S.K. Barar, Publisher: S Chand & Co Ltd.

7. Lewis's Pharmacology 4 edition, John Jacob Lewis, James Crossland Publisher: Harcourt

Brace/Churchill Livingstone.

8. Basic and Clinical Pharmacology 12 edition, Betram G. Katzung , Susan B. Masters, Anthony

J. Frevor, Publisher: McGraw‐Hill Medical.

9. Text book of Human Physiology, 11th edition, Elsevier, Ed. Guyton and Hall.

10. Gray's Anatomy, 40th Edition ‐ The Anatomical Basis of Clinical Practice, Expert Consult ‐

By Susan Standring, PhD, DSc, Churchill Livingstone.



‐ demonstrate integrated knowledge and understanding in the listed core topics and to

understand the fundamental principles of pharmacokinetics that underlie the absorption,


distribution, metabolism and elimination of drugs in the body and thereby affect drug

effectiveness.

‐ acquire and build advanced knowledge and understanding of rationale behind designing

different dosing regimens of particular drugs in specific patient populations.

‐ able to understand how specific patient characteristics and genetics can affect the response

to a particular class of drugs.

GENERAL PHARMACOGNOSY

1. GENERAL

1.1. COURSE TITLE: General Pharmacognosy

1.2. *COURSE CODE: DC.PH241.15


1.4. CREDITS: 09


1.6. PRE‐REQUISITES: Biology

1.7. SYLLABUS COMMITTEE MEMBERS: Dr Sunil K Mishra, Dr S. Hemalatha and Dr A N Sahu

2. OBJECTIVE

To study broader view of different aspects of herbal drugs.

3. COURSE CONTENTS

Unit I. Definition, scope and practice of Pharmacognosy (1L)

Unit II. Nomenclature and taxonomical (Family) study of medicinal plants and animal derived

drugs (1L)

Unit III. Classification of Crude drugs (1L)

Unit IV. Concept and understanding of alternative system of medicine: Ayurveda, Siddha,

Naturopathy, Yoga, Homeopathic etc. (3L)

Unit V. Role of medicinal plants in national economy (2L)

Unit VI. Cultivation, Collection, Processing, Commerce (transport and marketing),

Deterioration and Storage of crude drugs (4L)

Unit VII. General morphological and diagnostic microscopical characters of leaf, stem, root,

bark, flower, seed and fruit crude drugs (4L)

Unit VIII. Principle and procedure of microtome sectioning and staining with preparation of

permanent slides (2L)

Unit IX. General biosynthetic pathways of secondary metabolites (2L)

Unit X. Studies of Traditional Drugs: Common vernacular names, botanical sources,

morphology, chemical nature of chief constituents, pharmacology, categories and common

uses of following indigenous drugs: Amla, Shatavari, Punarnava, Shankhapushpi, Brahmi,

Ashwagandha, Guduchi, Bel, Garlic, Tulsi and Neem (6L)

4. READINGS

4.1 TEXTBOOK:

Evans WC, Trease and Evans – Pharmacognosy, 15th edn., WB Saunders, London, 2002.


Wallis TE, Textbook of Pharmacognosy, 5th edn., CBS Publishers and Distributors, New Delhi.



Students will come to know the significance and scope of herbal drugs.

PHARMACEUTICAL ANALYSIS

1. GENERAL

1.1. COURSE TITLE: PHARMACEUTICAL ANALYSIS



1.4. CREDITS: 8


1.6. PREREQUISITIES: Chemistry ‐ I

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S.K. Singh, Dr. Senthil Raja A, Dr. Ashok Kumar

2. OBJECTIVE

The course aims to provide an understanding of the basic principles of pharmaceutical

analysis covering the classical analytical methods of pharmaceutical importance and to enable

the students to acquire the theoretical and practical knowledge of relevant analytical

principles and procedures.

3. COURSE CONTENTS

Unit I. Fundamentals of volumetric analysis, methods of expressing concentration,

standardization, primary and secondary standards. Sources of errors in volumetric analysis

and their avoidance, standard or the Gaussian error distribution curve. (3L)

Unit II. General principles and pharmaceutical applications of acidimetry, alkalimetry,

oxidation‐reduction and precipitation methods as exemplified by standard reagents such as

sodium hydroxide, Potassium hydrogen phthalate, Potassium permanganate, Potassium

dichromate, sodium thiosulphate, silver nitrate etc. (6L)

Unit III. Non‐aqueous titrations: Types of non‐aqueous titrations as per I.P. Non‐aqueous

solvents. Assay of drugs by non‐aqueous titrations. (3L)

Unit IV. Complexometric titrations: Theory, stability of metal complexes, chelates, pM

indicators, complexometric assays of inorganic drugs. (3L)

Unit V. Miscellaneous Methods: Principles and analytical applications of Diazotization

titrations, Karl‐Fischer titration and Oxygen flask combustion method. (3L)

Unit VI. Extraction procedures of separation of drugs from excipients. (2L)

Unit VII. Construction, theory and application of modern electro‐chemical instruments used in

pharmaceutical analysis: Electrode assemblies, Electrical potential, pH measurement,

Potentiometry, Conductometry, Polarography and Amperometry. (6L)

LABORATORY

1. Preparation and standardization of standard reagents – 1 turn

2. Acidimetric/alkalimetric assay of organic compounds – 2 turns

3. Redox assay of organic compounds/drugs – 2 turns

4. Non‐aqueous titration of organic compounds/drugs – 2 turns

5. Complexometric assay of inorganic drugs – 2 turns

6. Diazotization titration – 1 turn


7. Potentiometric and conductometric assays – 3 turns

EXPLORATORY PROJECT

1. GENERAL

1.1. COURSE TITLE: EXPLORATORY PROJECT



1.4. CREDITS: 5


1.6. PREREQUISITIES: Nil

2. OBJECTIVE

The course aims to provide an opportunity to the student to undertake a project work of his

or her interest wherein he or she will perform some hands‐on experiment to get some early

exposure to the research areas/streams of pharmaceutical sciences and technology.


After completion of six month exploratory project the student would be able to select his or

her streams in which he or she wish to gain some expertise and skills. This would also help the

student to take up an exciting stream project in the sixth and seventh semester.

UNIVERSAL HUMAN VALUES 2: SELF, SOCIETY AND NATURE

1. GENERAL

1.1. TITLE: Universal Human Values 2: Self, Society and Nature

1.2. COURSE CODE: HU.H201.14


1.4. CREDITS: 5

1.5. SEMESTER OFFERED: Even

1.6. PREREQUISITE: Universal Human Values 1: Self & Family (desirable); 4‐day Harmony‐2

Workshop (co‐requisite).

2. OBJECTIVE

The objective of the course is four fold:

1. Sensitization of student towards issues in society and nature.

2. Understanding (or developing clarity) of nature, society and larger systems, on the basis

of human relationships and resolved individuals.

3. Strengthening of self reflection.

4. Development of commitment and courage to act.

(For elaboration on some of the above, consult course description for Universal Human

Values 1: Self and Family).

3. COURSE CONTENTS

Unit I. In Universal Human Values 2 course, the focus is more on understanding society and

nature on the basis of self and human relationships.

Unit II. Purpose and motivation for the course.


Unit III. Recapitulation (from the previous course) on ideas of self, pre‐conditioning, and

natural acceptance.

Unit IV. Harmony in the self. Understanding human being as co‐existence of self and body.

Identifying needs and satisfying needs of self and body. Self observations. Handling peer

pressure.

Unit V. Recapitulation on relationships. Nine universal values in relationships. Reflecting on

relationships in family. Hostel and institute as extended family. Real life examples.

Unit VI. Teacher‐student relationship. Shraddha. Guidance. Goal of education.

Unit VII. Harmony in nature. Four orders of nature – material order, plant order, animal order

and human order. Salient features of each. Human being as cause of imbalance in nature.

(Film “Home” can be used.)

Unit IX. Human being as cause of imbalance in nature. Depletion of resources – water, food,

mineral resources. Pollution. Role of technology. Mutual enrichment not just recycling.

Unit X. Prosperity arising out of material goods and understanding of self. Separation of

needs of the self and needs of the body. Right utilization of resources, Understanding the

purpose they try to fulfil.

Unit XI. Recapitulation on society. Five major dimensions of human society. Fulfillment of

the individual as major goal. Justice in society. Equality in human relationships as naturally

acceptable. Establishment of society with abhaya (absence of fear).

Unit XII. Ethical human conduct. Values, character and netikataa. Professional ethics.

Conduct as an engineer or scientist. Holistic human being through holistic education in just

order.

4. READINGS

4.1 Text Book

1. Human Values and Professional Ethics by R R Gaur, R Sangal, G P Bagaria, Excel Books, New

Delhi, 2010

4.2 Reference Books

1 JeevanVidya: EkParichaya, ANagaraj, JeevanVidyaPrakashan, Amarkantak, 1999.

2 Human Values, A.N. Tripathi, New Age Intl. Publishers, New Delhi, 2004.

3 The Story of Stuff (Book).

4 The Story of My Experiments with Truth ‐ by Mohandas Karamchand Gandhi

5 On Education ‐ J Krishnamurthy

6 Siddhartha ‐ Hermann Hesse

7 Old Path White Clouds ‐ ThichNhatHanh

8 On Education ‐ The Mother

9 Diaries of Anne Frank ‐ Anne Frank

10 Life and Philosophy of Swami Vivekananda

11 Swami Vivekananda on Himself

12 Small is Beautiful ‐ E. F Schumacher.

13 Slow is Beautiful ‐ Cecile Andrews

14 Economy of Permanence ‐ J C Kumarappa

15 Bharat Mein Angreji Raj ‐ PanditSunderlal


16 Mahatma and the Rose

17 The Poet and the Charkha

18 Rediscovering India ‐ by Dharampal

19 Hind Swaraj or Indian Home Rule ‐ by Mohandas K. Gandhi

20 Swaraj by Arvind Kejriwal

21 India Wins Freedom ‐ Maulana Abdul Kalam Azad

22 Ramakrishna kijeevani ‐ Romain Rolland (English)

23 Vivekananda ‐ Romain Rolland (English)

24 Gandhi ‐ Romain Rolland (English)

25 Autobiography of a Yogi – by ParamhansaYogananda

26 Gandhi and Question of Science – Sahasrabudhe


At the end of the course, students are expected to become more aware of their surroundings,

society, social problems and their sustainable solutions, while keeping human relationships

and human nature in mind. They would have better critical ability. They would also become

sensitive to their commitment towards what they believe in (humane values. humane

relationships and humane society). It is hoped that they would be able to apply what they

have learnt to their own self in different day‐to‐day settings in real life, at least a beginning

would be made in this direction.

SEMESTER 5 OPEN ELECTIVE I* (To be included)

MICROBIOLOGY AND BIOTECHNOLOGY

1. GENERAL

1.1. COURSE TITLE: MICROBIOLOGY & BIOTECHNOLOGY

1.2. *COURSE CODE: MS.BO301.16


1.4. CREDITS: 9

1.5. *SEMESTER OFFERED: 5th

1.6. PREREQUISITES: Nil

1.7. SYLLABUS COMMITTEE MEMBERS: A K Srivastava. Dr. A.N.Sahu, Dr.Senthil Raja A

2. OBJECTIVE

To provide a basic understanding about microbiology and biotechnology relevant to

biochemical, biomedical and pharmaceutical disciplines. This will enable students to gain

knowledge to undertake advanced level courses pertaining to pharmaceutical and biomedical

sciences, and other interdisciplinary engineering courses.

3. COURSE CONTENTS

Unit I. General techniques of microbiology, morphology, life history, mode of nutrition and

cultivation of bacteria, yeasts, moulds and common protozoa. Common infections,

communicable diseases, causative organisms, and route & mode of infections. (4 Lectures)


Unit II. Principles of isolation and identification of pure culture, different staining methods,

preparation of staining solutions and culture media. Effects of physical and chemical agents

on bacteria, disinfectants and antiseptics, mode of action and standardization of disinfectants.

(2 Lectures)

Unit III. Principles of sterilization, efficiency of various methods of sterilization with special

reference to thermo labile medicaments, cleaning and sterilization of glassware,

medicaments, surgical dressings. (2 Lectures)

Unit IV. Aseptic methods, mode of contamination and determination of degree of

contamination. Aseptic handling of sterile materials, surgical and medicaments and test for

sterility of medicaments, culture media, ligatures and sutures. (3 Lectures)

Unit V. Immunology: Principles, immune system, cellular and humoral immunity,

immunological tolerance, antigen – antibody reactions and their applications. Active and

passive immunization, Vaccines and their preparations, standardization and storage. (4

Lectures)

Unit VI. Genetic recombination: Gene cloning and their applications. Development of

hybridoma for monoclonal antibodies and their medicinal applications. Study of

macromolecules produced by biotechnology such as insulin, GH, Hbs Ag, streptokinase etc. (3

Lectures)

Unit VII. Antibiotics, historical development of antibiotics, screening of soil for organisms

producing antibiotics, fermenter, its design, control of different parameters; isolation of

mutants, factors affecting rate of mutation, design of fermentation process, isolation of

fermentation products with special reference to penicillin or vitamin B12. (5 Lectures)

Unit VIII. Enzyme immobilization, techniques of enzyme immobilization, factors affecting

enzyme kinetics; Study of some of the immobilized enzymes; Immobilization of bacteria and

plant cells. (3 Lectures)

Unit IX. Basics of plant and animal tissue culture technology (2 Lectures)

*LABORATORY: 3 hrs per week (Basic microbiological experiments)

4. READINGS

4.1 TEXTBOOK

Pharmaceutical Biotechnology by S.P.Vyas and V.K.Dixit, CBS Publishers, New Delhi.

Biology of Microorganisms, 6th Edition, T D. Brock & M.T Madigan, Prentice‐Hall International

Inc., New Jersey, USA 1991

Biotechnology, 2nd, Completely Revised Edition, Vol. 1‐12, H.J.Rehm & G.Reed (series editors),

VCH, Weinheim, Germany, 1993


Frontiers of Microbiology, G. C. Walker & D. Kaiser (eds.), American Society for Microbiology,

Washington, D.C., USA, 1993


Equip the students with the working knowledge of microbiology and biotechnology. Help to

acquire essential knowledge to choose specialized areas with additional requirements such

as bio‐sensors, computational pharmacology, bioinformatics, molecular biology, cell

mechanobiology, community healthcare, new drug discovery, etc.


PHARMACEUTICAL TECHNOLOGY

1. GENERAL

1.1. COURSE TITLE: PHARMACEUTICAL TECHNOLOGY



1.4. CREDITS: 11


1.6. PREREQUISITES: Physical Pharmaceutics

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. B.Mishra, Mr. A.K. Srivastava, Ms. Ruchi Chawa

(Convener)

2. OBJECTIVE

The course aims to provide an overview of the theories of formulation of pharmaceutical

formulations. The understanding of the properties enables the students to acquire a

specialized/research level knowledge and understanding of advanced topics in formulation

development, and advanced pharmaceutical sciences.

3. COURSE CONTENTS

Unit I. Introduction to Disperse Systems including Interfacial Phenomena. (2 Lectures)

Unit II. Suspension – Objective, Theory, Properties of ideal suspension, Interfacial properties,

Electrical properties at the interfaces, Electrical double layer, Zeta Potential, Nernst Potential,

Application and Formulation consideration. (7 lectures)

Unit III. Emulsion‐General considerations, Definition and types of formulation of emulsions,

Emulsification processes. Stability and Preservation of Emulsion. Evaluation of emulsions and

official emulsion products. (5 lectures)

Unit IV. Colloids and gels: Types, solute permeation to and through colloids and gels –

theories affecting solute permeation; preparations and evaluation. ( 3 lectures)

Unit V. Suppository – Dosage form characteristics, Therapeutic uses, Factors affecting drug

absorption from rectal suppositories, Types of suppository bases, Manufacture of

suppositories, Evaluation and Packaging. (5 lectures)

Unit VI. Capsules‐Materials for capsules, Method of production, Soft gelatin capsules,

Manufacture, Processing control, Stability and Packaging. (7 lectures)

Unit VII. Manufacturing of tablets: different forms, selection of adjuvants, techniques of

granulation, compression and coating, Fundamentals of physics of tablet making and

Evaluation of Tablets.(6 lectures)

Unit VIII. Coating – Principles and Procedures. (4 lectures)

*LABORATORY

Formulation and evaluation of various dosage forms.

Evaluation of incompatibility: physical, chemical and biological.

4. READINGS:


1. Cooper and Gunns’ “Tutorial Pharmacy” ed. S.J.Carter, CBS Publishers, Delhi.

2. “Bentley’s Textbook of Pharmaceutics”, EA Rawlins, ELBS Bacilliere Tindall.


3. “Modern Pharmaceutics: G.S.Banker and C.T.Rhodes, Marcel Dekker Inc., NY.



demonstrate integrated knowledge and understanding in the listed core topics and the

impact of variations of the vital formulation properties on the stability of dosage form

acquire and build advanced knowledge and understanding in specialised areas like

formulation development, nanopharmaceuticals

analyse the research literatures of relevant topics and able to present them.

GENERAL PHARMACOTHERAPEUTICS

1. GENERAL

1.1. COURSE TITLE: GENERAL PHARMACOTHERAPEUTICS

1.2. *COURSE CODE (if known): DC.PH331.16


1.4. CREDITS: 9


1.6. PREREQUISITES: General Pharmacology

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. Sanjay Singh (Convener), Dr. Vikas Kumar, Dr.

Sairam Krishnamurthy

2. OBJECTIVE

The main objective of this course is to provide ground structure of basic principles and topics

of pharmacotherapeutics, and to facilitate study of the use of drugs as therapeutic agents,

their administration, pharmacokinetics, effectiveness, their side effects and toxicity. The

learning objective of this subject is to also explain the rational use of therapeutic agent

according to proposed therapeutic indications.

3. COURSE CONTENTS

Study of pharmacological actions, mechanism of actions, adverse drug reactions, interactions

and applications of following:

Unit I. Cardiovascular System: Digitalis and cardiac glycosides, Anti‐hypertensive drugs,

Antianginal drugs, Antiarrythmic drugs, Drugs used in atherosclerosis drugs. (13 Lectures)

Unit II. Hemopoietic system: Hematinics and growth hormones, Anticoagulants, Vitamin K

and Hemostatic agents, Fibrynolytic and anti‐platelet drugs, Blood and plasma volume

expanders. (7 Lectures)

Unit III. Respiratory system: Anti‐asthmatic drugs including bronchodilators and mucolytics,

Anti‐tussive and expectorants, Respiratory stimulants. (7 Lectures)

Unit IV. Urinary system: Fluid and electrolyte balance restorers, Diuretics and antidiuretics. (6

Lectures)

Unit V. Gastrointestinal disorders: Antacids, anti‐secretary and anti‐ulcer drugs, Laxatives and

antidiarrhoeal drugs, Appetite stimulants and suppressants, Emetics and anti‐emetics. (6

Lectures)

4. READINGS

4.1* REFERENCE BOOKS:




Company.
















‐ understand safe, appropriate, and economical use of medications through the application

of specialized skills knowledge.

‐ accumulate experience and knowledge and transforming it into improved medication

therapy for patients.

‐ describe the principles of quality use of medicines issues and can implement it for upcoming

future research.

NATURAL DRUGS AND EXCIPIENTS

1. GENERAL

1.1. COURSE TITLE: NATURAL DRUGS AND EXCIPIENTS



1.4. CREDITS: 11


1.6. PRE‐REQUISITES: General Pharmacognosy

1.7. SYLLABUS COMMITTEE MEMBERS: Dr S. Hemalatha, Dr Sunil K Mishra and Dr A N Sahu

2. OBJECTIVE

To study different chemical categories of herbal drugs and their scientific study

3. COURSE CONTENTS

Unit I. Introduction and significance of natural drugs and excipients (1L)

Basic understanding and classification of each of the following phytochemical class; study of

the biological sources, cultivation, collection, preparation, production chemical constituents,

substitutes, adulterants, uses, diagnostic macroscopic and microscopic features and specific

chemical tests, trade & commerce of following groups of drugs:


Unit II. Carbohydrates and derived products: Agar, Acacia, Honey, Isabagol, Pectin, Starch

Tragacanth and Xanthan gum, (3L)

Unit III. Lipids: Bees wax, Castor oil, Cocoa butter, Codliver oil, Linseed oil, Cottonseed oil,

Corn oil, Peanut oil, Sesame oil and Wool fat (3L)

Unit IV. Resins: Study of Drugs Containing Resins and Resin Combinations like Podophyllum,

Cannabis, Capsicum, Asafoetida, Benzoin, Turmeric and Ginger (4L)

Unit V. Tannins: Study of tannins and tannin containing drugs ‐ Catechu and Myrobalan (1L)

Unit VI. Volatile oils: Coriander, Cinnamon, Lemon peel, Orange peel, Caraway, Dill, Clove,

Fennel, Cardamom & Musk (2L)

Unit VII. Glycoside containing drugs: (3L)

Saponins: Liquorice, Ginseng and Dioscorea; Cardioactive glycosides: Digitalis, Squill and

Strophanthus; Anthraquinone glycosides: Aloe, Senna and Rhubarb

Unit VIII. Alkaloid containing drugs: (4L)

Pyridine‐Piperidine: Tobacco; Tropane: Belladonna, Hyoscyamus, and Datura; Quinoline and

Isoquinoline: Cinchona, and Opium; Indole: Ergot, Rauwolfia, Catharanthus, Nux‐vomica and

Physostigma; Steroidal: Kurchi.

Unit IX. Natural colors, sweetners and flavours (2L)

Unit X. Pharmaceutical fibres: Cotton, Jute, Flax, Hemp, Silk, Wool, regenerated & synthetic

(3L)

Unit XI. Drugs / excipients from mineral origin: Talc, Kaolin, Bentonite, Kieselguhr & Asbestos

(2L)

Unit XII. Pharmaceutical enzymes from plant, animal and microbial source, description,

production and uses (5L)

Unit XIII. Marine Pharmacognosy (2L)

Unit XIV. Natural Allergens (2L)

XV. Bitter Principles (2L)

4. READINGS

4.1 TEXTBOOK:


2. Shah B and Seth AK, Textbook of Pharmacognosy and Phytochemistry, 1st edn., Elsevier,

New Delhi, 2010.


1. Wallis TE, Textbook of Pharmacognosy, 5th edn., CBS Publishers and Distributors, New

Delhi.


Students will come to know regarding morphology, microscopy, chemical constituents and

uses of crude drugs.

PROFESSIONAL COMMUNICATION

1. GENERAL

1.1 TITLE: PROFESSIONAL COMMUNICATION

1.2.*COURSE CODE: LM. HL301.14



1.4. CREDITS: 8


1.6. SYLLABUS COMMITTEE MEMBERS: Prof. P. K. Panda

2. OBJECTIVE

The objective of this course is to acquaint the students about the mode and procedure of

professional communication in work places. Since communication takes resources and its

proper use can save time and human resources they should develop an attitude to become

more particular in managing specific communication in a given context.

3. COURSE CONTENTS

1. Introduction to Professional Communication

1.1 Professional Communication for Engineering and Technology

1.2 Communication Model and Function of Professional Communication

1.3 Basics of Technical Communication

1.4 Basics of Technical Writing

2. Basic Writing Skills

2.1 Function of sentence structures

2.2 Use of phrases and clauses in sentences

2.3 Importance of proper punctuation

2.4 Common Errors in writing

2.5 Organizing principles of paragraphs and documents

2.6 Techniques for writing precisely

3. Writing for professional requiremtns

3.1 Letters

3.2 Memos

3.3 Proposals

3.4 Technical Reports

4. Vocabulary Building

2.1 The concept of word formation and technical Vocabulary

2.2 Root words from foreign languages and their use in scientific terminology

2.3 Acquaintance with prefixes and suffixes from foreign languages in English to form

derivatives used in science and technology.

5. Oral Presentation Skills

4.1 Planning a Presentation, Body Language, Voice, Preparing for Questions, Use of pictorial

presentations.

4.2 Strategies of descriptive, informative and persuasive oral presentation (purpose,

evidence and occasion)

4.3 Facing the Interview.

4.4 Presentation with Audio visual aids.

4. READINGS

Practical English Usage. Michael Swan. OUP. 1995.

Basic Communication Skills for Technology. Andrea J. Rutherford. Pearson Education. 2002.


Technical Writing: Process and Product. S.J. Gerson and S.M. Gerson Pearson Education.

2006.

Technical Communication: A Reader Centered Approach. Paul V. Anderson.

Technical Report Writing Today. D.G. Riordan and S.E. Pauley. Biztantra. 2008.


Students will gain knowledge on brief overview of the subject.

SEMESTER 6 OPEN ELECTIVE II* (To be included)

PHARMACEUTICAL JURISPRUDENCE

1. GENERAL

1.1. COURSE TITLE: PHARMACEUTICAL JURISPRUDENCE



1.4. CREDITS: 6


1.6. PREREQUISITES: Nil

1.7. SYLLABUS COMMITTEE MEMBERS: Prof. B.Mishra, Mr. A.K. Srivastava (Convener), Dr. S.K.

Mishra, Ms. Ruchi Chawa

2. OBJECTIVE

The course aims to provide an understanding of the various aspects of regulatory guidelines in

manufacturing, marketing and use of pharmaceuticals, cosmetics and toilet products.

3. COURSE CONTENTS

Unit I. Historical introduction to pharmaceutical legislations, Drugs and Cosmetics act and

rules and amendments thereto, Pharmacy Act & NDPS, Dangerous drugs act and rules.

Medicinal and toilet preparations act and rules, Drugs and magic remedies act. Industries act.

Medicinal termination of Pregnancy Act. Code of Pharmaceutical Ethics, Poison Act. (15

lectures)

Unit II. Controls on labels and labelling, packaging and storage. (6 lectures)

Unit III. Price control act. (6 lectures)

Unit IV. Drug Regulatory Affairs – New Drug Application (NDA), Investigational New Drug

(IND), ANDA, Methods of filing Application and data to be submitted. (6 lectures)

Unit V. Intellectual Property Rights (6 lectures)

4. READINGS


Pharmaceutical Jurisprudence by N.K.Jain, CBS Publishers, New Delhi.



Understand the importance and role of regulatory guidelines in manufacturing, use and

marketing of pharmaceutical products.


CHEMISTRY OF SYNTHETIC DRUGS

1. GENERAL

1.1. COURSE TITLE: CHEMISTRY OF SYNTHETIC DRUGS



1.4. CREDITS: 11


1.6. PREREQUISITES: Pharmaceutical Chemistry, Bioorganic and Medicinal Chemistry

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S.K. Singh, Dr. S.K. Shrivastava, Dr. Senthil Raja A

2. OBJECTIVE

The course aims to provide an understanding of the basic topics of synthetic medicinal

chemistry covering various medicinal categories of drugs and to enable the students to

acquire the theoretical and practical knowledge of relevant multistep organic synthetic


3. COURSE CONTENTS

Unit I. Classification, structure‐activity relationship, synthesis and mechanism of action of

drugs (including latest drugs) belonging to the following categories: General Anesthetics, Local

Anaesthetics, Analeptics, Sedatives and Hypnotics (Barbiturates), Anticonvulsants, Opioid

analgesics, Antitussives, Antispasmodics, Antihistaminics, Tranquillizers (Phenothiazines).

(15L)

Unit II. Study of the design and synthesis of the drugs belonging to the following classes:

NSAIDs, Antihypertensives, Antiarrhythmics, Anti‐anginal agents, Diuretics, Anticoagulants

(Heparin and Oval), Antithyroids, Oral Hypoglycemics. (12L)

Unit III. Medicinal chemistry of chemotherapeutic agents: Antineoplastics (Alkylating Agents

and Antimetabolites), Antibacterial, Antifungal, Antituberculars, Antileprotics, Anti‐helmintics,

Antiamoebics, Antimalarials, Antiviral, Anti‐HIV agents. (12L)

LABORATORY

Multistep synthesis of carbocyclic drugs – 5 turns

Multistep synthesis of heterocyclic drugs – 5 turns

Assay (volumetric/Instrumental) of synthesized drugs – 3 turns

4. READINGS

S N Pandeya, Textbook of Medicinal Chemistry (Synthetic & Biochemical Approach) Vol I & II, SG

Publishers, Varanasi

Thomas Norgady & Donald F Weaver, Medicinal Chemistry: Biochemical Approach, Oxford

University Press.

Graham L. Patrick, An Introduction to Medicinal Chemistry, 4th Edition, 2009, Oxford University

Press.


After the successful completion of this course, the students will be able

‐ to demonstrate the mechanisms of multistep synthetic reactions and their applications in

bulk drug synthesis.


‐ to analyse the structure‐activity relationship of various chemical class of drugs and their

analogous derivatives.

DEPARTMENT ELECTIVE I: PH312/PH322/PH332/PH342 (1 out of 4 Courses)

HOSPITAL AND CLINICAL PHARMACY

1. GENERAL

1.1. COURSE TITLE: HOSPITAL AND CLINICAL PHARMACY

1.2. COURSE CODE: DE.PH312.17


1.4. CREDITS: 12


1.6. PREREQUISITES: Physical Pharmaceutics, Pharmaceutical Technology

1.7. SYLLABUS COMMITTEE MEMBERS: Prof. B.Mishra (Convener), Mr. A.K. Srivastava, Prof.

Sanjay Singh, Dr. Ruchi Chawa

2. OBJECTIVE

The course aims to provide an understanding of the core principles of dispensing of dosage

forms and to enable students to acquire specialised/research level knowledge of the clinical

aspects of appropriate dispensing of these dosage forms and applications in biochemical,

biomedical and pharmaceutical sciences.

3. COURSE CONTENTS

Unit I. Prescription‐form of the prescription order, components of prescription, handling of

prescription, legal considerations. (3 lectures)

Unit II. Dispensing Pharmacy: Principles and procedures of dispensed products ‐ Solutions,

suspensions, emulsions, powders, granules and oral unit dosage forms, ointments, creams,

pastes, gels, suppositories and pessaries, etc. (4 lectures)

Unit III. Introduction to different pharmacokinetic parameters and clinical Pharmacokinetics,

Therapeutic drug monitoring, Bioavailability. Important disorders and their management. (8

lectures)

Unit IV. Concept of essential drugs and rational drug use, and pharmacovigilance. (6 lectures)

Unit V. Adverse drug reactions and Drug interactions. (3 lectures)

Unit VI. General principles and management of clinical toxicity, essential drug use and rational

drug combinations. (5 lectures)

Unit VII. Drug use during infancy and in the elderly patients (Pediatrics & Geriatrics), Drug Use

during pregnancy. (6 lectures)

Unit VIII. Labeling and drug information. (4 lectures)

4. READINGS:


J.G.Wagner – Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publications,

Hamilton, PA, USA.

“Textbook of Hospital Pharmacy”, M.C.Allwood and J.T. Fell, Blackwell Scientific Publications,

Oxford.

Cooper and Gunn’s, “Dispensing for Pharmaceutical Students”, S.J.Carter, CBS Publishers, Delhi.




‐ properly dispense a dosage form with an understanding of the clinical implications of the

mode of dispensing of the dosage form.

‐ acquire and build advanced knowledge and understanding in specialised areas like

biopharmaceutics, pharmacology and dosage formulation design.

CHEMISTRY OF NATURAL DRUGS

1. GENERAL

1.1. COURSE TITLE: CHEMISTRY OF NATURAL DRUGS



1.4. CREDITS: 12


1.6. PREREQUISITES: Pharmaceutical Chemistry, Bioorganic and Medicinal Chemistry

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S.K. Singh, Dr. S.K. Shrivastava, Dr. Senthil Raja A

2. OBJECTIVE

The course aims to provide an understanding of the basic topics of natural medicinal

chemistry covering various chemical categories of natural drugs and to enable the students to

acquire the theoretical and practical knowledge of relevant multistep organic synthetic


3. COURSE CONTENTS

Unit I. Alkaloids: General methods of extraction and structure determination, classification

and synthesis of the following alkaloids: Ephedrine, Nicotine, Atropine, Cocaine, Papaverine,

Pilocarpine, Physostigmine. Gnoscapine (Isoquinoline), Yohimbine (Indole), Conessine

(Steroidal) and Vasicine (Quinazole) (10L)

Unit II. Antibiotics – Structural determination, synthesis and assay of penicillin; Semi‐synthetic

penicillin; cephalosporins, Chemistry of streptomycin and tetracyclines. (8L)

Unit III. Cardiac glycosides: Digitoxin, gitoxin, strophanthin. (5L)

Unit IV. Steroids: General chemistry and configuration of steroids with special reference to

Cholesterol, Ergosterol, Vitamin D and Bile acids. Chemistry of Steroidal hormones ‐ Sex

hormones (testosterone, progesterone and estrogens) and corticoids (Cortisone). (8L)

Unit V. Chemistry of Terpenes: Isolation from natural sources, structure elucidation and

properties of compounds, e.g. Terpineol, Carvone, Menthol, Citral. (8L)

LABORATORY

1. Multistep synthesis of natural drugs – 5 turns

2. Identification of alkaloids/antibiotics/steroids – 5 turns

3. Assay (volumetric/Instrumental) of natural drugs – 3 turns

4. READINGS

I.L. Finar, The stereochemistry and Chemistry of Natural Products, ELBS/Longman. Vol 2. 4th

edition. 1963.



At the end of the course the student would be familiar with the structural elucidation and

characterization of at least fifty drugs derived from natural sources.

NEUROPHARMACOLOGY

1. GENERAL

1.1. COURSE TITLE: NEUROPHARMACOLOGY



1.4. CREDITS: 12


1.6. PREREQUISITES: General Pharmacology, General Pharmacotherapeutics

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. Sairam Krishnamurthy (Convener), Dr. Sanjay

Singh, Dr. Vikas Kumar

2. OBJECTIVE

The neuropharmacology course will discuss the drug‐induced changes in functioning of the

nervous system. The specific focus of this course will be to provide a description of the

cellular and molecular actions of drugs on synaptic transmission. This course will also refer to

specific diseases of the nervous system and their treatment in addition to giving an overview

of the techniques used for the study of neuropharmacology.

3. COURSE CONTENTS

Unit I. Introduction to neuropharmacology. (2 lectures)

Unit II. Neurotransmitters and their receptors and pathways: Classification of

neurotransmitters (Glutamate and GABA, Catecholamines, Acetylcholine, Purine, Histamine

and serotonin) and their receptors and signalling pathways in the central nervous system (8

lectures).

Unit III. Techniques in neuropharmacology. Behavioral neuropharmacology;

Electrophysiological methods and Molecular biological methods in neuropharmacology. (5

lectures)

Unit IV. Traumatic central nervous injuries: Pathophysiology and pharmacology of traumatic

brain and spinal cord injury. (5 lectures)

Unit V. Neurodegenerative disorders: Pathophysiology and pharmacology of drugs used in

neurodegenerative disorders. (6 lectures)

Unit VII. Neuropathic pain: Pathophysiology and pharmacology of drugs used in neuropathic

pain. (6 lectures)

Unit VIII. A study of the receptors, pharmacological implications and possible physiological

role of Neuropeptide Y, Substance P, Neurokinin, Vasopressin, Cytokines, Chemokines,

Endorphins, Neutrophins & nitric oxide in central and peripheral tissues. (7 lectures)

LABORATORY

To perform bioassay of histamine on the ileum of guinea pig.

To study the effect of drugs on isolated frog heart.

To study the effect of drugs on blood pressure (BP) and heart rate (HR) of dog.

To perform DRC of acetylcholine on frog rectus abdominis muscle.


To study the effect of physostigmine on the DRC of acetylcholine on frog rectus abdominis

muscle.

To study the effect of atropine on the DRC of the acetylcholine on rat ileum.

To perform bioassay of serotonin on rat stomach strip by three point assay method.

To perform bioassay of atropine on rat ileum by interpolation method.

To study the effect of drugs on locomotor activity in mice using actophotometer.

To study the analgesic effect of drugs in mice using Eddy's hot plate.

To study the anticonvulsant effect of drugs using electro‐convulsiometer.

To study the effects of CNS suppressant and skeletal muscle relaxant drugs on mice using

rota‐rod apparatus.

4. READINGS

4.1 TEXT BOOKS

1. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 2 edition, Nestler,

Eric, Steven Hyman, and Robert Malenka, Publisher: McGraw‐Hill Professional. ISBN:

9780071481274.

2. The Biochemical Basis of Neuropharmacology, 8th edition, Cooper, Jack R., Floyd E. Bloom,

and Robert H. Roth, Publisher: Oxford University Press. ISBN: 9780195140088.

3. Articles from high‐impact Journals.


Upon successful completion of this course, students will:

‐ be able to demonstrate a fundamental knowledge of neuropharmacology.

‐ acquire knowledge to understand and apply major issues, concepts, and subject areas in

neuropharmacology.

‐ be able to demonstrate sufficient knowledge about pharmacotherapy of major neurological

disorders.

‐ acquire fundamental knowledge of neuropharmacological techniques and their applications

INDUSTRIAL PHARMACOGNOSY

1. GENERAL

1.1. COURSE TITLE: INDUSTRIAL PHARMACOGNOSY

1.2. *COURSE CODE (if known): DE.PH342.18


1.4. CREDITS: 12


1.5 PRE‐REQUISITES: General Pharmacognosy, Natural Drugs & Excipients

1.6. SYLLABUS COMMITTEE MEMBERS: Dr Dr A N Sahu, Dr Sunil K Mishra and Dr S. Hemalatha

2. OBJECTIVE

To study different extraction technologies for medicinal and aromatic plants

3. COURSE CONTENTS

Unit I. Overview of Indian herbal sector (1L)

Unit II. Typical overview of a herbal drug industry –Layout, division, sub divisions & their

functions (2L)


Unit III. Analysis of crude extracts, fractions and isolated compounds (Qualitative &

Quantitative – Chemical, Spectroscopic, Titration & Chromatographic methods) (7L)

Unit IV. Determination of bitterness value, hemolytic activity, tannins, swelling index, foaming

index, pesticide residues, heavy metals, microorganisms, aflatoxins and radioactive

contaminants (7L)

Unit V. Crude fractionation procedures: Choice of fractionation method and Common

fractionation methods: Precipitation, solvent‐solvent extraction, distillation, dialysis and

electrophoresis (5L)

Unit VI. Purification of Crude Essential Oils; Microdistillation, Thermomicrodistillation and

Molecular Distillation Techniques (4L)

Unit VII. Solid Phase Micro‐extraction and Headspace Trapping Extraction (3L)

Unit VIII. Review of recent scientific and traditional literature along with methods used for

biological screening of Anti‐fertility, Anti‐diarrhoel, Anti‐inflammatory agents, Analgesic, Anti‐

pyretic, Anti‐gastric ulcer, Diuretic agents of plant origin (7L)

Unit IX. Case study related to various herbal drug industries / divisions (3L)

4. READINGS

4.1 TEXTBOOK:


Aromatic Plants, 1st edn., International Centre For Science And High Technology, Trieste,

2008.

2. Reddy KRC, Bhaisajya Kalpana Vijnanam, 2nd edn., Chaukhamba Sanskrit Bhawan,Varanasi,

2008.

3. Pharmacopoeial standards for Ayurvedic formulation, Revised edn., CCRAS, Ministry of

Health and Family Welfare, New Delhi, 1987.


1. Wallis Houghton PJ and Raman A, Laboratory handbook for the fractionation of natural

extracts, 1st edn., Chapman & Hall, 1998


New Delhi, 2010.


Students will learn regarding different classical and novel methods of phytoconstituents

extraction from medicinal & aromatic plants and preliminary evaluation parameters of

medicinal plants.

STREAM PROJECT (DC.PH392.16)

SEMESTER 7 OPEN ELECTIVE III** (To be included)

PHARMACEUTICAL INSTRUMENTAL ANALYSIS

1. GENERAL


1.1. COURSE TITLE: PHARMACEUTICAL INSTRUMENTAL ANALYSIS



1.4. CREDITS: 9


1.6. PREREQUISITES: Pharmaceutical Analysis

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S.K. Singh (Convener), Dr. Senthil Raja A, Dr. Ashok

Kumar

2. OBJECTIVE

The course aims to provide an understanding of the basic principles of pharmaceutical

instrumental analysis covering various modern instrumental analytical methods of

pharmaceutical importance and to enable the students to acquire the theoretical and

practical knowledge of relevant analytical principles and procedures.

3. COURSE CONTENTS

Unit I. Theory, principles, instrumentation and applications of following instrumental methods

used in analysis of pharmaceutical compounds. (12L)

UV Spectroscopy

Fluorescence spectroscopy

Nephelometry and turbidometry

IR Spectroscopy

Polarimetry

Radiochemical analysis: Applications of Geiger Muller and Scintillation counters

Atomic absorption spectroscopy

Unit II. Chromatography: Theory of chromatography, plate theory, Factors affecting

resolution, van Deemter equation. Instrumentation and pharmaceutical applications of

following chromatographic techniques: Paper Chromatography and Column Chromatography,

TLC, HPLC, GLC and HPTLC. (12L)

Unit III. Paper Electrophoresis (Elementary concepts), Counter current separation and

Centrifugation. (2L)

LABORATORY

Analysis of drugs by Colorimetry (1 turn), UV‐VIS spectrophotometry (1 turn),

Spectroflourometry (1 turn), Nephlometry and turbidimetry (2 turns), IR Spectrophotometry

(2 turns)

Analysis of drugs by chromatography: TLC (1 turn), Paper chromatography (1 turn)

Assay of drugs by refractometry (1 turn) and Polarimetry (1 turn)

4. READINGS

Instrumental Methods of Analysis: Willard, N., CBS Publishers, New Delhi.


After the completion of this course, the student will be able to

‐ conduct instrumental based analysis of organic compounds and drug products

‐ analyse and interpret the spectral data of drugs and drug products


CHEMOTHERAPY

1. GENERAL

1.1. COURSE TITLE: CHEMOTHERAPY

1.2. *COURSE NUMBER: DC.PH431.17


1.4. CREDITS: 9


1.6. PRE‐REQUISITES: General Pharmacology, General Pharmacotherapeutics

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. Vikas Kumar (Convener), Dr. Sanjay Singh, Dr.


2. OBJECTIVE

The course content designed to provide students essential knowledge of the treatment of

disease using chemical agents or drugs that are selectively toxic to the causative agent of the

disease, such as a virus, bacterium, or other microorganism.

3. COURSE CONTENTS

Unit I. General principles of chemotherapy. (5 Lectures)

Unit II. Sulphonamides and co‐trimoxazole. (3 Lectures)

Unit III. Antibiotics: Pencillins, cephalosporins, tetracyclines and chloramphenicol,

aminoglycosides, macrolide, lincosamide, glycopeptide, polypeptide antibiotics and urinary

antiseptics (9 Lectures)

Unit IV. Chemotherapy of malaria, tuberculosis, leprosy, fungal diseases, viral diseases,

urinary tract infections and sexually transmitted diseases. (9 Lectures)

Unit V. Chemotherapy of malignancy and immunosuppressing agents. (9 Lectures)

Unit VI. Anthelmintics , anti‐amoebics and anti‐protozoal drugs. (4 Lectures)

4. READINGS

4.1. *REFERENCE BOOKS



Company.

















‐ understand the listed core topics and the role of microorganism in the progression and

manifestation of a disease.

‐ Implement the basic principle of chemotherapy for rational use of existing drugs and to

contribute for future prospective of chemotherapeutic agents.

DEPARTMENT ELECTIVE II: PH411/PH421/PH432/PH441/PH452 (1 out of 5 Courses)

BIOPHARMACEUTICS

1. GENERAL

1.1. COURSE TITLE: BIOPHARMACEUTICS


1.3. CREDITS: 9


1.5. PREREQUISITES: Pharmaceutical Technology

1.6. SYLLABUS COMMITTEE MEMBERS: Prof. B.Mishra, Mr. A.K. Srivastava, Prof. Sanjay Singh,

Ms. Ruchi Chawa (Convener)

2. OBJECTIVE

The course aims to provide an understanding of the core principles of pharmaceutical

evaluation and their impact on in‐vivo performance and to enable students to correlate the

in‐vivo and in‐vitro performance of the drugs keeping in mind the holistic picturesque of

formulation development.

3. COURSE CONTENTS

Unit I. BCS classification of drugs. (2 lectures)

Unit II. Biopharmaceutical evaluation of tablets, capsules, liquid orals, parenterals,

dermatological. (9 lectures)

Unit III. Bioavailability in drug development: Explanation of terms: Bioavailability (Absolute

and Relative), Purpose and methods of bioavailability studies using blood level and urinary

excretion data, Federal Requirements. (6 lectures)

Unit IV. Bioequivalence, chemical and clinical and therapeutic equivalence, pharmaceutical

alternative;

Unit V. Assessment methods of pharmaceutical and therapeutic equivalence; possible

reasons for non‐equivalence. (6 lectures)

Unit VI. Principles of Drug Dissolution Related to Bioavailability and bioequivalence;

Dissolution Rate; Elementary idea of in vitro and in vivo correlation and its significance. (6

lectures)

Unit VII. Photostability studies, stability studies of drug products and API. (8 lectures)

4. READINGS


“Modern Pharmaceutics:, G.S.Banker and C.T.Rhodes, Marcel Dekker Inc., NY.

J.G.Wagner – Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publications,

Hamilton, PA, USA.




Understand the importance and role of pharmaceutical evaluation in in‐vivo performance of

dosage forms.

Understand various drug delivery systems and suitability of a formulation for specific targeted

treatment module/regimen.

Acquire and build advanced knowledge and understanding in specialised areas like novel drug

delivery systems.

COMPUTATIONAL CHEMISTRY

1. GENERAL

1.1. COURSE TITLE: COMPUTATIONAL CHEMISTRY



1.4. CREDITS: 09


1.6. TOTAL CONTACT HOURS: 39 theory hours (3 hrs per week)

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S.K.Singh, Dr. S.K.Shrivastava, Dr. Senthil Raja A (

Convener)

2. OBJECTIVE

The course aims to provide an understanding of the basic principles of computational

chemistry including their applications in drug design and discovery.

3. COURSE CONTENTS

Unit I. Introduction to computational chemistry and molecular modeling. (2L)

Unit II. Molecular Mechanics and Force Fields: Force fields, potential energy functions, inter

and intramolecular interactions, empirical parameters. Molecular mechanics calculations,

energy minimization, conformational analysis, vibrational frequencies, and normal mode

analysis. molecular potential energy surfaces and the concepts of global and local minima.

(6L)

Unit III. Molecular Simulations: Monte Carlo Simulations, Molecular Dynamics Simulations,

Equations of motion and force calculations. Ensembles. (3L)

Unit IV. Liquids: Solvents (Polar and non‐polar), Solutions, Acidity and Basicity, and

Computation of pKa Continuum Solvation Models. (3L)

Unit V. Free Energy Simulations. Free Energy Perturbation ‐ Free energy of solvation and

Partition coefficients. Thermodynamic Integration and Umbrella Sampling. Hydrophobic

Effects and Ion‐Pair Interactions in Water. (4L)

Unit VI. Quantum Mechanics: Gaussian and GaussView, Hartree‐Fock Theory and Basis Sets,

Semiempirical Methods, Electron Correlations, Density Functional Theory. (4L)

Unit VII. Structure and Dynamics of Proteins: Protein Structure and PDB, Building Models for

Protein Structure and Energy Calculations, Normal Mode Analysis, Molecular Dynamics of

Proteins, Solvation. (6L)


Unit VIII. Combined QM/MM Methods. QM and MM methods, Solvation and Solvent Effects ‐

Polarization and Reaction profiles in solution. Protein‐Ligand Interactions, Modeling

Enzymatic Reactions. (6L)

Unit IX. Molecular modeling applications: One case study each related to quantitative

structure‐activity relationship studies, structure/ligand drug design and homology modeling.

(5L)

4. READINGS

Hans‐Dieter Holtje, Molecular Modeling. Basic Principles and Applications, 3rd Edition, 20087,

Wiley‐VCH.

F. Jensen, Introduction to Computational Chemistry, (Wiley, New York, 1999). Good

introductory textbook covering a variety of topics.



‐ Build molecular models and demonstrate the computational properties of small organic

molecules and proteins

‐ Correlate the computational parameters of molecules with their functions

‐ Analyze the 3D structure of proteins, ligands and protein‐ligand interactions.

NEUROPHARMACOTHERAPEUTICS

1. GENERAL

1.1. TITLE: NEUROPHARMACOTHERAPEUTICS

1.2. *COURSE NUMBER: DE.PH432.17


1.4. CREDITS: 9

1.5. SEMESTEROFFERED: 7th

1.6. PRE‐REQUISITES: General Pharmacology and General Pharmacotherapeutics

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. Vikas Kumar (Convener), Dr. Sanjay Singh, Dr.


2. OBJECTIVE

The main objective of this course is to provide ground structure of basic principles and topics

of pharmacotherapeutics, and to facilitate study of the use of drugs as therapeutic agents,

their administration, pharmacokinetics, effectiveness, their side effects and toxicity. The

learning objective of this subject is to also explain the rational use of therapeutic agent

according to proposed therapeutic indications.

3. COURSE CONTENTS

Study of pharmacological actions, mechanism of actions, adverse drug reactions, interactions

and applications of following:

Unit I. Central Nervous System: General anaesthetics, Alcohols and treatment of alcoholism,

Sedatives and hypnotics, Antipsychotic drugs, Antianxiety agents and Antidepressants,

Narcotic analgesics, Anti‐epileptic drugs, Anti‐Parkinsonian drugs. (13 Lectures)


Unit II. Peripheral Nervous System: Parasympathomimetics, Parasympatholytics,

Sympathomimetics, sympatholytics, Ganglionic stimulants and blocking agents, Local

anaesthetic agents, Neuromuscular blocking agents. (13 Lectures)

Unit III. Autacoids: Histamine, 5‐HT and their antagonists, Prostaglandins, Thromoboxanes,

Leukotrienes and Kinins, Nonsteroidal anti‐inflammatory drugs and Antipyretic‐Analgesics. (6

Lectures)

Unit IV. Endocrine system: Thyroid hormones and Anti‐thyroid drugs, Insulin and Oral

Hypoglycaemic drugs, Drugs acting on uterus, Estrogens, Progestins and Oral Contraceptives.

(7 Lectures)

4. READINGS

4.1. *REFERENCE BOOKS


Goodman Gilman, Theodore W.Rall, Alan Nies and Palmer Taylor, Publisher: Macmillan

Publishing Company.







5. Pharmacology and Pharmacotherapeuties 22 edition, R.S.Satoskar, Nirmala B. Rege









‐ demonstrate the general principles and methodology of receptor‐ligand binding methods,

drug‐receptor interactions and their application to the study of the molecular pharmacology

of receptors.

‐ build advance understanding in specialized areas like receptor mapping and isolation

technique to highlight the molecular and structural basis of agonist activation and receptor

scaffolding mechanisms.

‐ analyse the research literatures of molecular pharmacology and able to contribute in

advance research.

PLANT TISSUE CULTURE

1. GENERAL

1.1. COURSE TITLE: PLANT TISSUE CULTURE

1.2. *COURSE CODE (if known): DE.PH342.17



1.4. CREDITS: 9


1.5. PRE‐REQUISITES: Biology and General Pharmacognosy

1.6. SYLLABUS COMMITTEE MEMBERS: Dr Sunil K Mishra, Dr A N Sahu and Dr S. Hemalatha

2. OBJECTIVE

To study plant tissue culture techniques to obtain secondary metabolites of medicinal value

3. COURSE CONTENTS

Unit I. Introduction, history, laboratory organization and aseptic manipulation (7L)

Unit II. Culture media: Constituents, pH and preparation (4L)

Unit III. Tissue & Cell culture: Types and methods (6L)

Unit IV. Cytodifferentiation and cellular totipotency (6L)

Unit V. Protoplast fusion and cultures, artificial seeds, micropropogation of medicinal and

aromatic plants. Genetic stability of tissue cultures (6L)

Unit VI. Applications in secondary metabolite production (4L)

Unit VII. Germplasm conservation (3L)

Unit VIII. Case study, market search and recent advancements in plant tissue culture (3L)

4. READINGS

4.1 TEXTBOOK:


2. Sambrook and Russel, Molecular cloning – A Laboratory manual, 3rd edn., Vol.1‐3, CSHL

press, New York, 2001.

3. Rastogi S and Pathak N, Genetic Engineering, 1st edn., Oxford University Press, New Delhi,

2009.

4. Razdan MK, Introduction to plant tissue culture, 2nd edn., Oxford & IBH publishing Co. Pvt.

Ltd., New Delhi, 2004.



New Delhi, 2010.


Students will learn regarding different plant tissue culture techniques used to obtain

secondary metabolites of medicinal importance.

.

SPECTROSCOPY

1. GENERAL

1.1. COURSE TITLE: SPECTROSCOPY


1.3. CONTACT HRS: 09


1.5. TOTAL CONTACT HOURS: 39 theory hours (3 hrs per week)

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. S.K. Singh, Dr.Senthil Raja A, Dr. Ashok Kumar

2. OBJECTIVE


The course aims to provide an understanding of advanced spectroscopic techniques of

pharmaceutical importance and to enable the students to acquire the theoretical knowledge

of relevant spectral methods used in the characterization of drugs, drug‐excipients and drug‐

targets.

3. COURSE CONTENTS

Unit I. Vibrational Spectroscopy: Theory, instrumentation, data interpretation and

pharmaceutical applications of Fourier Transform infrared absorption spectroscopy (FTIR),

reflectance FTIR techniques like FTIR‐ATR, FTIR‐PAS & DRIFTS FTIR. (8L)

Unit II. Solution NMR spectroscopy: Principles of proton (H‐1), carbon (C‐13) NMR

spectroscopy, interpretation of H‐1 and C‐13 spectral data of organic compounds and drugs.

Introduction to FT NMR methods and protein NMR spectroscopy. (8L)

Unit III. Mass spectrometry: Principles of modern ionization methods and mass analyzers (Q,

TOF and FT‐ICR), and applications of MS in the analysis of small drugs and macromolecules. (8L)

Unit IV. X‐ray diffraction methods: X‐ray powder diffraction (XRPD) ‐ theory and principles

XRPD in the analysis of drugs and drug formulations including case studies. Single crystal XRD

(SC‐XRD) ‐ principles, methods of crystallization, data collection and phase analysis, case

studies involving the three dimensional structure determination of proteins/protein‐ligand

complexes, protein data bank and its applications in drug discovery. (8L)

Unit V. Chiroptical Spectroscopy: Theory and principles of Circular Dichroism, CD methods –

Electronic CD, Vibrational CD, Fluorescence CD and protein CD and their applications in drug

discovery. (7L)

4. READINGS

4.1 TEXTBOOK

Silverstein, Bassler and Morill: Spectrometric identification of Organic Compounds: John

Wiley and Sons, Inc.

William Kemp: Organic Spectroscopy


At the end of the course, the students can

‐ apply the spectroscopic principles in their research projects dealing with synthetic/natural

drugs, drug‐polymer complex etc.

‐ interpret the IR, NMR, MS spectra of organic compounds/drugs

ACADEMIC WRITING FOR SCIENCE AND TECHNOLOGY

1. GENERAL

1.1. TITLE: ACADEMIC WRITING FOR SCIENCE AND TECHNOLOGY

1.2. *COURSE CODE: LM.HL501.14


1.4. CREDITS: 8

1.5. *SEMESTER OFFERED: 7th

1.6. SYLLABUS COMMITTEE MEMBERS: Prof. P, K. Panda

2. OBJECTIVE

To acquaint the students to the rhetoric of academic/research writing.


3. COURSE CONTENTS

1. Introduction to English for special purpose (ESP)

(a) Theory and practice of academic writing (English for global communication needs)

(b) Overcoming writer’s block(from outlining to Story boarding)

(c) Introduction to types of discourse(Expressive, expository, persuasive, analytical)

(d) Critical thinking in academic writing(Ability to select and reject content)

(e) Basics of writing (clarity in use of words and sentences)

(f) Creating textual dynamics and concepts of formatting.

2. Organization principles in academic writing

(a) Problem Solution

(b) Chronological

(c) Spatial

(d) Order of priority

(e) Sequential

(f) Cause and effect

(g) Analytical

(h) Formal classification

(i) Partitioning

(j) Segmenting

3. Preparation of Pictorial presentations (types and utility)

(a) Pictures

(b) Graphs

(c) Charts

(d) Figures

(e) Diagrams

4. Self-editing procedures:

(a) Adding,

(b) Deleting,

(c) Comparing,

(d) Contrasting,

(e) Linking,

(f) Grammar Check,

(g) Spell Check,

(h) Proofreading etc.

5. Introduction to Documentation and style manuals

(A) Integratingothers’ text into research material

(a) Quoting

(b) Paraphrasing

(c) Summarizing

(d) Writing a thesis statement

(e) Writing introduction and conclusion


(B) Introduction to different types of standard documentation procedures (MLA, APA, IEEE

etc.)

6. Introduction to IPR (intellectual property rights and plagiarism)

(a) Intellectual property right

(b) Introduction to Copy Right laws

(c) How to avoid plagiarism

7. Writing assignments

(a) Research papers

(b) Technical Reports

(c) News letters

(d) Book reviews

(e) Organization profiles

4. READINGS

4.1. *REFERENCE BOOKS:

1. How to Write and Publish a Scientific Paper. R.A. Day. Greenwood Press. 2011.

2. Scientific English: a guide to scientist and professionals. 2ndEdn. R.A. Day. Orient Black

swan. 2000.

3. Assignment and Thesis Writing. 4th Edition. Millicent Poole and Jonathan Anderson. Wiley

and Sons. 2011.

4. Science and Technical writing. Philip Ruben. 2ndEdn. Rutledge (Foundation Books). 2004.

5. Critical Thinking, Academic Writing and Presentation Skills. Marilyn Anderson. Promod K.

Nayar and Madhuchanda Sen. Pearson. 2012.


Students will gain practical knowledge to prepare documents necessary for academic

purposes.

STREAM PROJECT (DC.PH491.17)

SEMESTER 8

OPEN ELECTIVE IV***

DOSAGE FORMULATION DESIGN

1. GENERAL

1.1. COURSE TITLE: DOSAGE FORMULATION DESIGN



1.4. CREDITS: 9


1.6. PREREQUISITIES: Pharmaceutical Technology

1.7. SYLLABUS COMMITTEE MEMBERS: Prof. B.Mishra, Mr. A.K. Srivastava (Convener), Prof.

Sanjay Singh, Ms. Ruchi Chawa


2. OBJECTIVE

The course aims to provide an understanding of the core principles of formulating drug

delivery systems with a fundamental understanding of the role of pre‐formulation studies and

pre‐clinical studies and to enable students to acquire specialised/research level knowledge of

novel drug delivery systems like nano‐pharmaceuticals, multi‐particulate drug carriers.

3. COURSE CONTENTS

Unit I. Pre‐formulations studies of dosage forms; Pharmaceutical aids; their classification,

nature, properties and uses in formulations. (7 lectures)

Unit II. Prolonged action and controlled release Drug Delivery Systems: Principles, methods of

prolongation and control of Drug Release and their evaluation. (8 lectures)

Unit III. Parenteral medications: types of injections, clinical administration, product

components and manufacturing process, design and working of clean room. (6 lectures)

Unit IV. Dermatological preparations and Cosmetology: Their formulation, bases used,

stability and their evaluation. (6 lectures)

Unit V. Aerosols: principles, different systems, propellants, containers and valve systems. (6

lectures)

Unit VI. Pharmaceutical packaging – Materials and Technical Aspects. (6 lectures)

4. READINGS


Leon Lachmen, H.A.Lieberman and J.L.Kanig, “The Theory and Practice of Industrial

Pharmacy”, Lea & Febiger, Philadelhia/Varghese Publishing House, Mumbai.

Martindale’s Extra Pharmacopoeia (Ed. JEF Reynolos), The Pharmaceutical Press, London.

S.H.Willing: Good Manufacturing Practices for Pharmaceuticals, Marcel Dekker Inc., NY.

United States Pharmacopoeia, U.S.P. Convention Inc., Rockville, Madison (USA).

British Pharmacopoeia, 2003, Her Majesty’s Stationary Office, University Press, Cambridge,

U.K.



‐ Understand the importance of pre‐formulation studies in dosage formulation design.

‐ Understand various drug delivery systems and suitability of a formulation for specific

targeted treatment module/regimen.

‐ Acquire and build advanced knowledge and understanding in specialised areas like

biopharmaceutics, and novel drug delivery systems.

ANALYTICAL PHARMACOGNOSY

1. GENERAL

1.1. COURSE TITLE: ANALYTICAL PHARMACOGNOSY



1.4. CREDITS: 9


1.6. PRE‐REQUISITES: General Pharmacognosy


1.7. SYLLABUS COMMITTEE MEMBERS: Dr A N Sahu, Dr Sunil K Mishra and Dr S. Hemalatha

2. OBJECTIVE

To study quality control aspects of crude drugs and plant drug analysis.

3. COURSE CONTENTS

Unit I. Analysis of crude extracts, fractions and isolated compounds (Qualitative &

Quantitative – Chemical, Spectroscopic, Titration & Chromatographic methods) (7L)

Unit II. Quantitative microscopy (2L)

Unit III. Determination of bitterness value, hemolytic activity, tannins, swelling index, foaming

index, pesticide residues, heavy metals, microorganisms, aflatoxins and radioactive

contaminants (7L)

Unit IV. Basic concepts and applications of spectroscopic techniques in plant drug analysis (2L)

Unit V. Clean‐up techniques to remove unwanted substances from plant extracts (3L)

Unit VI. Crude fractionation procedures: Choice of fractionation method and Common

fractionation methods: Precipitation, solvent‐solvent extraction, distillation, dialysis and

electrophoresis (5L)

Unit VII. Purification of Crude Essential Oils ; Microdistillation, Thermomicrodistillation and

Molecular Distillation Techniques (4L)

Unit VIII. Solid Phase Micro‐extraction and Headspace Trapping Extraction (3L)

Unit IX. Review of recent scientific and traditional literature along with methods used for

biological screening of Anti‐fertility, Anti‐diarrhoel, Anti‐inflammatory agents, Analgesic, Anti‐

pyretic, Anti‐gastric ulcer, Diuretic agents of plant origin (6L)

4. READINGS

4.1 TEXTBOOK:



2. WHO, Quality Control Methods for Medicinal Plant Materials. World Health Organization,

Geneva, 1998.




New Delhi, 2010.


Students will learn the quality control aspects of crude drugs and the spectroscopic and

chromatographic techniques of plant drug analysis.

DEPARTMENT ELECTIVE II: PH413/PH422/PH433/PH443/PH453 (1 out of 5 Courses)

INDUSTRIAL PHARMACY

1. GENERAL

1.1. COURSE TITLE: INDUSTRIAL PHARMACY


1.3. CREDITS: 9



1.5. TOTAL CONTACT HOURS: 39 hours (3 per week)

1.6. SYLLABUS COMMITTEE MEMBERS: Prof. B.Mishra, Mr. A.K. Srivastava, Prof. Sanjay Singh

Ms. Ruchi Chawa (Convener)

2. OBJECTIVE

The course aims to provide an understanding of the various aspects of industrial operations of

processes and help the student understand the importance of proper planning and execution

of industrial processes.

3. COURSE CONTENTS

Unit I. Principles of improved tablet production system design: Raw materials, Cost efficiency.

(3 lectures)

Unit II. Tablet Pilot Plant: Designs, Stability features. (4 lectures)

Unit III. Large volume Parenterals: Analysis of costs; Operations efficiency management. (3

lectures)

Unit IV. Production planning and scheduling. (4 lectures)

Unit V. Materials handling, operation sequencing. (3 lectures)

Unit VI. Master Production Records: Format, Flow sheets. (4 lectures)

Unit VII. Process validation strategies. (4 lectures)

Unit VIII. Raw materials: Establishment of specifications, test procedures, sampling

procedures, Assay validation during product development phase. (4 lectures)

Unit IX. Application of ISO, TQM and documentation to the production of different types of

pharmaceutical products. (3 lectures)

Unit X. Product validation: Principles; Parameters; Product Fault Detection mechanisms. (3

lectures)

Unit XI. Special problems of pharmaceutical packaging. (4 lectures)

4. READINGS


Leon Lachmen, H.A.Lieberman and J.L.Kanig, “The Theory and Practice of Industrial

Pharmacy”, Lea & Febiger, Philadelhia/Varghese Publishing House, Mumbai.

Martindale’s Extra Pharmacopoeia (Ed. JEF Reynolos), The Pharmaceutical Press, London.




‐ understand the industrial operations related to process and material handling.

‐ understand various types of documentation and validation involved in industries.

COMPUTATIONAL DRUG DESIGN

1. GENERAL

1.1. COURSE TITLE: COMPUTATIONAL DRUG DESIGN



1.4. CREDITS: 09



1.6. PREREQUISITES: Computational Chemistry (desired)

1.7. SYLLABUS COMMITTEE MEMBERS: Dr. S.K.Singh, Dr. S.K.Shrivastava, Dr. Senthil Raja A

(Convener)

2. OBJECTIVE

The course aims to provide an understanding of the fundamental and modern principles of

the process of drug discovery and development from the identification of novel drug targets

to the introduction of new drugs into clinical practice. The course covers the basic and

modern drug design methods, lead identification and optimization strategies, etc., to provide

a complete theoretical knowledge of drug design to the students.

3. COURSE CONTENTS

Unit I. Introduction to drug design. Biochemistry of drug actions. Role of drug design in drug

discovery, traditional and modern concepts of drug design, classification of

receptors/enzymes and ion channels, Lock and key approach, Ligand receptor interactions,

Physiochemical and stereochemical aspects of drug design, bioisosterism. (5L)

Unit II. Computer aided drug design/Computational tools in drug design and discovery: CADD

Strategies, Theory and principle of molecular modeling, molecular mechanics and molecular

dynamic force fields. Virtual molecular screening/ in silico screening methods, vHTS and pHTS,

Applications of target based and ligand based virtual screening with suitable case studies. (8L)

Unit III. Pharmacokinetics and metabolism of drugs – General metabolic pathways of drugs,

rational drug design strategies for improving PK, PD and metabolic profile of drugs, prodrug

design, hard drugs and soft drugs. (5L)

Unit IV. Analog based drug design – Basic concepts, general strategies of analog based drug

design, Case studies. (5L)

Unit V. Structure‐based drug design – Basic concepts, druggability of targets and 3D

characterization of targets, recent case studies. (5L)

Unit VI. QSAR – Introduction to 2D and 3D QSAR analysis, QSAR parameters, Hansch and Free

Wilson analysis, Software tools used in QSAR analysis. (6L)

Unit VII. Combinatorial chemistry – Theory and principles of combinatorial chemistry,

methods of split and mixed synthesis and parallel synthesis, solid support organic synthesis

and its applications in combinatorial chemistry. (5L)

4. READINGS

Burger’s Medicinal Chemistry and Drug Discovery, 5th Edition, Vol. 1. Principles and Practice,

edited by M. E. Wolff, John Wiley & Sons: New York, 1995.

A Practical Guide to Combinatorial Chemistry, edited by A. W. Czarnik and S. H. DeWitt,

American Chemical Society: Washington DC, 1997.

Hugo Kubinyi, 3D QSAR in Drug Design: Theory Methods and Applications, 1994, Springer,

Netherlands.


The students can be able to

‐ understand the state‐of‐the‐art drug design technologies that drives the journey of a

new chemical compound from computer to clinical use.


‐ demonstrate the computational tools and methods used in the rational design of

drugs for a particular disease.

TOXICOLOGY

1. GENERAL

1.1. TITLE: TOXICOLOGY

1.2. COURSE NUMBER: DE.PH433.17

1.3. CONTACT HRS: 9


1.5. PRE‐REQUISITES:

1.6. SYLLABUS COMMITTEE MEMBERS: Dr. Sanjay Singh (Convener), Dr. Sairam

Krishnamurthy, Dr. Vikas Kumar

2. OBJECTIVE

Toxicology is the study of the nature, properties, effects, and detection of toxic substances

and their disease manifestation in humans. This course will provide a general review of

toxicology related to the human. Fundamental concepts will be covered including

dose‐response relationships, absorption of toxicants, distribution and storage of toxicants,

biotransformation and elimination of toxicants, target organ toxicity, teratogenesis,

mutagenesis, carcinogenesis, food allergy, and risk assessment. The course will examine

chemicals of interest and how they are tested and regulated. We will critically review case

studies and special topics.

3. COURSE CONTENTS

Unit I. Principles of toxicology: Introduction to toxicology and classification of toxic agents,

spectrum of undesired effects; characteristics of exposure; dose–response relationship;

variation in toxic responses; descriptive animal toxicity tests. (3 lectures)

Unit II. Mechanisms of toxicity: Evaluation across different models; target organs, cell death,

necrosis, apoptosis, oxidative stress, chromosome and DNA damage. (3 lectures)

Unit III. ADME and toxicokinetics: ADME and kinetics of toxicants. (3 lectures)

Unit IV. Toxicology of the liver: mechanisms of liver toxicity and methodological aspects. (2

lectures)

Unit V. Toxicology of the lung: toxicological pathophysiology, toxicological pathology and

mechanisms of toxicity. (2 lectures)

Unit VI. Chemical carcinogenesis & genetic toxicology: Mutagenicity and mechanisms of

mutagenesis; test systems in vitro, chromosome damage and chromosomal aberration test,

gene mutation, in vivo micronucleus tests in rodents, metaphase analysis. (3 lectures)

Unit VII. Neurotoxicology: Functional neuro‐toxicology and neurobehavioural toxicology. (3

lectures)

Unit VIII. Cardiovascular toxicology: Toxicological pathology and methodological aspects. (3

lectures)

Unit IX. Toxicology of blood: pathophysiology, toxicological pathology and mechanisms of

toxicity. (2 lectures)


Unit X. Toxicology of the kidney: Toxicological pathology and biochemical toxicology. (3

lectures)

Unit XI. Toxicology of the intestine: Toxicological pathology and source of intestinal toxicity.

(2 lectures)

Unit XII. Toxicology of the skin: Toxicological pathology and methodological aspects. (2

lectures)

Unit XIII. Reproductive toxicology & teratology: Assessment of male and female reproductive

toxicity; female reproductive toxicology; Neonatal toxicity. (3 lectures)

Unit XIV. Nanotoxicology: Toxicology of nanomaterials and formulations. (2 lectures)

Unit XV. Analytical toxicology: Analytic toxicology; analytic role in general toxicology; analytic

role in therapeutic monitoring; analytic role in biological monitoring. (3 lectures)

4. READINGS

4.1 TEXT BOOK

1. Cassarett & Doull’s Toxicology, 7th edition, Curtis Klaassen, Publisher: McGraw‐Hill

Professional.


1. Regulatory Toxicology, 2 edition, Shayne C Gad, Publisher: Informa Healthcare.

2. Goodman and Goodman and Gilman's: The Pharmacological Basis of Therapeutics 6 edition,

Alfred Goodman Gilman, Theodore W.Rall, Alan Nies and Palmer Taylor, Publisher: Macmillan

Publishing Company.

3. Clinical Pharmacology 8 edition, D.R. Laurence, P.N. Bennett, Morris J. Brown, Publisher:


4. The toxicologist’s pocket handbook, 2nd edition, Michael J derelanko, Publishers: CRCpress.

5. Relevant OECD, ICH, SCHEDULE Y guidelines.

6. Modern Medical Toxicology, 4 edition, VV Pillay, Publishers: Jaypee Publishers.


Upon successful completion of this course, students will:

‐ be able to demonstrate a fundamental knowledge of processes and endpoints in the

human body associated with exposure to toxic agents.

‐ acquire knowledge to understand and apply major issues, concepts, and subject areas

in toxicology.

‐ be able to demonstrate sufficient knowledge about the occurrence and significance of

major toxicants and be able to apply that knowledge for advanced analysis in the

context of the compounds, drugs and toxins.

NUTRACEUTICALS AND HERBAL COSMETICS

1. GENERAL

1.1. COURSE TITLE: NUTRACEUTICALS AND HERBAL COSMETICS

1.2. *COURSE CODE: DE.PH443.17



1.4. COREDITS: 9


1.6. PRE‐REQUISITES: General Pharmacognosy and Natural Drugs & Excipients

1.7. SYLLABUS COMMITTEE MEMBERS: Dr S. Hemalatha, Dr Sunil K Mishra and Dr A N Sahu

2. OBJECTIVE

To study about functional foods and nutraceuticals, including their health benefits,

development and regulation. It also includes the significance, method of preparation and

regulation of herbal cosmetics

3. COURSE CONTENTS

Unit I. Historical perspective, classification, scope & future prospects of nutraceuticals (1L)

Unit II. Nutraceuticals in treatment for cognitive decline, Nutraceutical remedies for common

disorders like Arthritis, Bronchitis, circulatory problems, Diabetes, Nephrological disorders,

Liver disorders, Osteoporosis etc. (7L)

Unit III. Different types of additives used in nutraceuticals. Analysis of these nutritional and

other ingredients in ethical and non‐ethical foods (3L)

Unit VI. Properties, structure and functions of various Nutraceuticals: Glucosamine,

Octacosanol, Lycopene, etc. (3L)

Unit V. Anti‐nutritional Factors present in Foods: Types of inhibitors present in various foods

and their method of inactivation. Assessment of nutritional status and Recommended Daily

allowances (3L)

Unit VI. Brief physiology of skin, hair and tooth (3L)

Unit VII. Raw materials and ingredients of herbal cosmetics including botanical extracts,

natural perfumes & fragrance, colors, preservatives and antioxidants (5L)

Unit VIII. Cosmetics for the skin, nails, hairs, oral and bath products (6L)

Unit IX. Analysis of cosmetics (2L)

Unit X. Safety and toxicity testing of various types of cosmetics (2L)

Unit XI. Packaging and labeling of cosmetics (2L)

Unit XII. Case study of market available nutraceutical and herbal cosmetic products & related

issues (2L)

4. READINGS

4.1 TEXTBOOK:


Aromatic Plants, 1st edn., International Centre For Science And High Technology, Trieste,

2008.

2. Sagarin and M.S.Balsam, Cosmetic Science and Technology, , John Wiley & sons, NY.

3. S.G.Thomssen, Modern Cosmetics, Universal Publishing Corporation, Mumbai.





New Delhi, 2010.



Students will learn about the scientific and technological aspects of functional foods,

nutraceuticals and herbal cosmetics; their formulation, identifying strengths, limitations, and

future directions. They will be able to demonstrate the health benefits of functional foods and

nutraceuticals.

QUALITY ASSURANCE

1. GENERAL

1.1. COURSE TITLE: QUALITY ASSURANCE



1.4. CREDITS: 9



1.7. SYLLABUS COMMITTEE MEMBERS: Dr.B. Mishra, Mr.A.K.Srivastava (Convener), Dr. Ruchi

Chawla

2. OBJECTIVE

To study quality assurance principles related to pharmaceuticals and biotechnological products

including the best practices of manufacturing and laboratory practices.

3. COURSE CONTENTS

Unit I. Introduction and scope of: cGMP, cGLP, ISO, TQM with reference to pharmaceutical

products. (6 lectures)

Unit II. ICH guidelines with respect to pharmaceutical and biological products and processes.

(6 lectures)

Unit III. Control of quality variation: raw materials control, in‐process items control, quality

assurance during packaging. (6 lectures)

Unit IV. Control and assurance of manufacturing process. (5 lectures)

Unit V. Regulatory drug analysis and interpretation of data. (6 lectures)

Unit VI. Validation of equipment, analytical instruments and manufacturing environment. (6

lectures)

4. READINGS

A.N.Martin: Physical Pharmacy, Lippincott Williams and Wilkins, Baltimore, USA.



After the completion of the course, the students can demonstrate the quality control

requirements of drugs and biological as per the regulatory guidelines.

HUMANITIES – New Course (to be included)

SEMINAR

1. GENERAL

1.1. COURSE TITLE: SEMINAR




1.4. CREDITS: 0



2. OBJECTIVE

This course is aimed to provide an opportunity to the students

‐ to develop the art of delivering seminar on selected recent topics covering all the areas of

pharmaceutical sciences and technology.

‐ to collect and compile the latest literature on the selected topics and also to enhance

their communication and presentation skills through interactive classroom sessions.

3. COURSE CONTENTS Recent and current topics from various streams of pharmaceutical sciences and technology.

SYLLABUS BOOKLET OF PROPOSED 4-YEAR B.PHARM. … · proposed 4-year b.pharm. programme applicable...

Documents

Transcript of SYLLABUS BOOKLET OF PROPOSED 4-YEAR B.PHARM. … · proposed 4-year b.pharm. programme applicable...