Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web...
Transcript of Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web...
![Page 1: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/1.jpg)
Microbiology Lecture: Antimicrobial Therapy and Drug ResistanceSpring 2016
I. The Fundamentals of Antibiotic Therapy
a. Selective Toxicity
b. Limited Spectrum of Activity
c. Bacteriostatic or Bacteriocidal
![Page 2: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/2.jpg)
II. Mechanisms of Actiona. Cell Wall Synthesis
![Page 3: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/3.jpg)
The New Kid on the block – Teixobactin (January 2015)
b. Membrane Integrity
![Page 4: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/4.jpg)
c. Metabolism i. Sulfa Drugs
d. DNA Synthesis and Integrity
i. Quinolones
ii. Metronidazole
![Page 5: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/5.jpg)
e. Transcription Inhibitors
f. Translation Inhibitors
i. Drugs that affect the 30S subunit
![Page 6: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/6.jpg)
ii. Drugs that affect the 50S subunit
![Page 7: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/7.jpg)
III. Antibiotic Resistancea. Mechanisms
b. Multidrug Resistance
![Page 8: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/8.jpg)
c. Development of Drug Resistancei. Overuse
ii. Improper Use
iii. Agricultural Use
d. Fighting Drug Resistance
i. Developing New Antibiotics1. Targeting Resistance Mechanisms
![Page 9: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/9.jpg)
2. Development of New Antibiotic Classes
3. Using Genomics to Identify New Targets
ii. Blasts from the Past
iii. It Takes Two
iv. Strategies for Extending Antibiotic Lifetimes
![Page 10: Susquehanna Universitycomenius.susqu.edu/biol/312/antibiotics and resistanc… · Web viewMicrobiology Lecture: Antimicrobial Therapy and Drug Resistance Spring 2016 The Fundamentals](https://reader033.fdocuments.in/reader033/viewer/2022060407/5f0fa6fc7e708231d44538cf/html5/thumbnails/10.jpg)