Suspension gel techology gelceuticals

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Gel Technology — Gelceuticals™

For additional information: http://www.geldocs.com/ohm.php

Do people actually consume the nutrients that will improve their health? Everyone starts with good intentions. A few pills here, a glass of juice there. But before long, pills get bothersome and glass bottles are less than portable.

How many times have we asked ourselves, “Now, why didn‘t I think of that?” So often, a very simple idea goes unnoticed as we continue doing things the same old way, year after year. Nutritional supplements are no different. For most of the last century, nutritional supplements—primarily available in pill and tablet form—have gained popularity. With the availability of each new supplement, we have been left with the same alternative: swallow one more pill.

What if we didn?t have to choke down another tablet? What if there was another option? What if somebody decided to deliver nutrients in a different form?

Good news! There’s a fresh new way to consume nutritional supplements, a new technology known as Gelceuticals™. This delivery mechanism isn’t just new, its better—it will revolutionize the way we take nutritional supplements and substantially increase the number of individuals who benefit from nutritional supplementation.

Through suspension gel technology, our daily nutrients can be taken anywhere, quickly and easily. Think about it: no glasses, no super-sized pills, no waterlogged juices, no ineffective sprays and creams—just pure, concentrated nutrients in an easy to take, readily absorbed, taste bud-busting gel. Entirely original, the Gelceutical market represents an untapped arena of wellness. And the landmark realization of the industry is Agel™. Agel stands at the head of a supplement revolution—incredible convenience, incredible flavor.

Why is gel technology so much better? Two very important factors influence the efficacy of nutritional supplements: 1) the proper timing of ingestion, and 2) the bioavailability of the nutrients. Because of these factors, gel technology represents a significant advance in the method of delivery for vitamins, minerals and other important food supplements. Gel suspension drastically facilitates ingestion of food supplements, increasing compliance

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with nutritional regimens that would otherwise go unheeded. It provides extreme convenience and allows for optimal timing of ingestion, thus maximizing nutritional efficacy. And, it optimizes the bioavailability of the nutrients that are suspended in gel form in order to maximize their physiologic effects.

Agel EXO

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EXO is the proprietary exotic antioxidant formula in our initial product offerings. Antioxidants are substances that help prevent cellular damage in our bodies. Our body has its own process of repair, but with the stress of current life-styles and the increasing amount of pollutants in the environment, we may need some extra help. Ideally, we can get most of the antioxidants we need by eating fruits and vegetables, essentials of a healthy diet. However, in today’s fast —paced world we sometimes replace fresh fruits and vegetables with less than ideal choices. Therefore, enhancing our less than optimal diet with an exceptional antioxidant supplement may be extremely beneficial.

EXO is a powerful blend of 14 different unique whole fruit purees and plant extracts from around the world, each with its own unique properties. This distinctive formula contains 14 potent botanicals that each when tested individually was found to have a very high total antioxidant capacity. Now imagine the extraordinary benefit of EXO, a highly concentrated gel, made up of not one but 14 of these antioxidant-rich fruits and plants. In independent testing, EXO’s antioxidant capacity as determined by an oxygen radical absorbance capacity (ORAC) rating was found to be quite extraordinary.

Optimum health requires adequate nutrition. Adequate nutrition involves balance, moderation and variety. Scientific literature suggests that the intake of a varied selection of antioxidants is much better than taking high doses of just one or two antioxidants. Since EXO is a highly concentrated gel containing a variety of antioxidant–rich botanicals, the multifaceted benefits of this formulation are truly unique.

Ingredients: Dark Grape, Cranberry, Bilberry, Aronia, Blueberry, Pomegranate, Aloe Vera, Para Guava, Noni, Acerola, Wolfberry, Açai, Ashwaganda, and Rooibos

Agel EXO uses Agel’s EXO™ gel will help you delay signs of age–related declines. Aging causes natural declines in your mobility, coordination, memory, vision, skin, hair and health. These signs of aging often lead to persistant health conditions. This exclusive Gelceutical™ blend of 14 all–natural fruits helps you age gracefully — slowing down the visible signs of aging.*

The Need

The NeedSigns of age-related declines originate with every breath of oxygen. Oxygen is the major source of harmful free radicals. Ironic that life-giving oxygen also causes signs of health declines with advancing years. Oxygen free radicals have an unstable, single electron (versus stable, paired electrons) enabling them to chemically alter lipids, proteins, carbohydrates and even DNA. An oxygen free radical “attacks” a biomolecule by “stealing”s one electron, thereby changing the “good biomolecule” into a reactive free radical, but restoring oxygen to a stable state. Continual creation of biological free radicals damages cells and tissues – leading to the visual signs of aging.*

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Aging is a 24/7 declining process resulting from alterations to our normal biochemistry within every cell of the body — free radical aging. Free radical aging results in less–responsive cells. The life-extension capabilities of the cell are weakened when sections of DNA experience free radical damage. Changing in DNA coding alters the biosynthesis of proteins and enzymes that maintain normal cell functions. This is why aging is such a slow, continuous process.*

The Solution

Agel’s EXO gel formulated with 14 exotic all–natural fruits and fruit extracts, each containing a wide–variety of antioxidants. EXO abounds with over 200 distinct antioxidants to shield, quench and repair the broadest spectrum of biological proteins, membrane lipids and nucleic DNA free–radicals. EXO is your greatest biological shield against the signs of age–related declines.*

Agel’s EXO GelBenefits:

1. Combats signs of age–related decline* 2. Supports youthful vision & recognition* 3. Maintains normal joint mobility* 4. Helps control youthful coordination* 5. Boosts immune function activity* 6. Enhances feelings of youthful energy* 7. Supports healthy cholesterol levels already within the normal range* 8. Guards healthy urinary tract health* 9. Shields the body from harmful free–radicals* 10. Reversing age–related losses in short–term memory*

Agel’s EXO Features:

1. Patent pending Gelceutical™ enhanced-bioactive technology 2. Over 200 natural antioxidants 3. Antioxidant BioShield™ antioxidant and immune activity 4. Antioxidant Recharging™ system*

The Mechanism

EXO’s antioxidant spectrum slows down signs of age–related decline. Regular consumption of EXO releases an active army of antioxidants in your bloodstream. EXO antioxidants work in two ways to minimize signs of aging — through EXO’s Antioxidant BioShield™ and through its exclusive Antioxidant Recharging?. EXO’s Antioxidant BioShield technology guards against free radical damage to both water-soluble and fat–soluble biomolecules. The Antioxidant BioShield is very protective due the variety of natural antioxidants within EXO’s 14 exotic fruits, including: flavonoids, proanthocyanins, anthocyanins, phenolic acids, polyphenols, carotenoids, vitamins, and essential minerals. EXO?s Antioxidant BioShield™ minimizes free radical bioactivity

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and repairs free radical damage to cellular DNA, lipids, proteins and enzymes. Agel’s Antioxidant BioShield also places the immune system on “surveillance alert” via active fruit polysaccharides against foreign invaders.*

Antioxidant Recharging™ is Agel’s exclusive formulation technology that regulates antioxidant bioactivity. For example, in the process of repairing a free radical–damaged biomolecule with the vitamin E antioxidant, vitamin E becomes “deactivated” as an antioxidant. With Agel’s exclusive Antioxidant Recharging™ system, the deactivated vitamin E is recharged by vitamin C. The resulting water–soluble, “deactivated” vitamin C is readily eliminated from the body following the recharging process. Agel’s EXO contains many examples of coordinated Antioxidant Recharging. EXO’s exclusive Antioxidant BioShield™ and Antioxidant Recharging™ provides you the best bioprotection against signs of aging — 24/7.*

The Ingredient

The exotic antioxidant-rich fruits in EXO represent the best berry and fruit sources from around the globe. Blueberries from the lush Pacific Northwest of USA, Dark-skinned grapes from Europe and North America, Cranberries from quiet waters of Northeastern USA, Bilberries from rich lands of Northern Europe, Aronia chokeberry from forests of Central Europe, Pomegranate from Persia and Mediterranea, Aloe vera gel from the arid Mexican plains, Noni fruit from mineral-rich Polynesian shores, Para guava from South America, Acerola cherry from Brazil , Wolfberries from China and Southeast Asia, Acai berries from Amazon rainforests, Ashwaganda from depths of India, Rooibos herb extract from Africa. These selected fruits are ranked highest in ORAC rating ? a rating of antioxidant bioactivity.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Agel EXO Açai

Açai (a-sigh-ee) (Euterpe oleracea) is considered to be one of the most nutritious fruits of the Amazon rainforest. It contains Vitamin B1 (Thiamin), Vitamin B2 (Riboflavin), Vitamin B3 (Niacin), Vitamin C, Vitamin E (tocopherol), iron, potassium, phosphorus and calcium. It also contains the essential fatty acids Omega 6 and Omega 9 (these are the healthy fatty acids), and many of the essential amino acids, with a protein profile similar to an egg. And, that is just for starters. What makes AÁai unique is that is very rich in anthocyanins, which are very potent antioxidants. In fact, this amazing fruit contains 33 times more anthocyanins than the red wine grape.

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Anthocyanins as a class of nutrients are important in their ability to help prevent atherosclerosis (clogged arteries), and generalized cellular damage caused by free radicals in the body. They are considered to be very helpful in the anti-inflammatory process, and may even help to lower LDL cholesterol (the bad cholesterol). In addition, they play an important role in neutralizing dangerous carcinogens.

Açai is an amazing fruit with many health benefits. But, what is truly amazing is that it is only one of the14 different exotic fruits and herbs contained in Agel EXO, each of which are loaded with health enhancing nutrients.

References

1: Lichtenthaler R, Rodrigues RB, Maia JG, Papagiannopoulos M, Fabricius H, Marx F. Int J Food Sci Nutr. 2005 Feb;56(1):53-64.

2: Hassimotto NM, Genovese MI, Lajolo FM. J Agric Food Chem. 2005 Apr 20;53(8):2928-35.

3: Del Pozo-Insfran D, Brenes CH, Talcott ST. J Agric Food Chem. 2004 Mar 24;52(6):1539-45.

Acerola

J Acerola (Malpighia glabra) is a fruit resembling the bing cherry that is believed to originate from the Yucatan peninsula in South America. Some of the largest plantings in modern times are in Brazil. It is one of the richest known food sources of vitamin C, and it is for this reason that this fruit has played an important role in South American herbal medicine. In addition, it has carotene content comparable to that of carrots, and is also a good supply of magnesium, and several of the B vitamins; niacin, pantothenic acid, vitamin B1 (thiamine), and vitamin B2 (riboflavin).

Vitamin C is a nutrient that must be supplied in the diet. It has many biological functions, including the formation and maintenance of collagen (the primary protein of skin and connective tissues), healthy maintenance of the liver and adrenal glands, and it is a powerful natural antihistamine. However, one of its most important roles is that of an antioxidant and its ability to help the body fight physiological stress. Our environment is filled with external stresses and pollutants that put our bodies under extraordinary pressure to maintain health. We are much more prone to infection and disease in our metropolitan environments and the intake of extra vitamin C can serve as an excellent adjunct to healthy living.

Some of the common ailments for which vitamin C is being taken in our modern society include: allergies, atherosclerosis (clogged arteries), bronchitis, cancer prevention, colds and flu, glaucoma, and skin wrinkles.

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Acerola is loaded with many important nutrients, and it is an important component of Agel EXO. It contributes synergistically with the other 13 exotic fruits and herbs to create a supplement with exceptional health-enhancing properties.

References

1: Hanamura T, Hagiwara T, Kawagishi H. Biosci Biotechnol Biochem. 2005 Feb;69(2):280-6.

2: Johnson PD. World Rev Nutr Diet. 2003;91:67-75. Review.

3: Visentainer JV, Vieira OA, Matsushita M, de Souza NE. Arch Latinoam Nutr. 1998 Sep;48(3):256-9.

Aloe Vera

References

1: Su CK, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J, Koong A, Goffinet D, Le QT. Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):171-7.

2: Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS. Aliment Pharmacol Ther. 2004 Apr 1;19(7):739-47.

3: Langmead L, Makins RJ, Rampton DS. Aliment Pharmacol Ther. 2004 Mar 1;19(5):521-7.

Aronia

Aronia (Aronia melanocarpa) is a shrub that is native to the northeastern part of the United States. It produces clusters of small dark purple berries that are also known as “black chokeberries.” It has close botanical ties to the bilberry and the cranberry in that is contains high levels of anthocyanins and flavonoids, both of which are very potent antioxidants. It has been reported that the aronia berry contains over five times greater levels of these compounds than the cranberry.

Antioxidants are so important in our modern day–to–day living as we are constantly being bombarded with oxidative stresses. Antioxidants are substances that prevent cellular damage by acting as scavengers and neutralize free radicals by donating electrons to these electron–deprived compounds. The body has its own mechanisms for dealing with free radicals, but they can be inadequate, particularly with the added stress of current life–styles and the increasing amount of pollutants in the environment. For optimal health, it is therefore necessary to complement these processes with antioxidants from our

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diet. Fortunately, antioxidants are abundantly present in fresh fruits and vegetables, which are an essential part of a healthy diet. However, as we substitute the intake of fresh fruits and vegetables in our diets with other “empty” calories, the need to take food supplements rich in antioxidants becomes increasingly important.

The Aronia berry is just one of 14 different exotic fruits and herbs contained in Agel EXO that is loaded with these important antioxidants.

References

1: Pilaczynska-Szczesniak L, Skarpanska-Steinborn A, Deskur E, Basta P, Horoszkiewicz-Hassan M. Int J Sport Nutr Exerc Metab. 2005 Feb;15(1):48-58.

2: Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA. J Agric Food Chem. 2004 Oct 6;52(20):6122-8.

3: Zheng W, Wang SY. J Agric Food Chem. 2003 Jan 15;51(2):502-9.

Ashwaganda

Ashwaganda (Withania somnifera), also known as “Indian ginseng”, is a small evergreen that comes from the drier parts of western India, northern Africa, the Mediterranean, and the Middle East. It is related to the tomato plant of North America, and all of its parts, including its roots, oval leaves, showy yellow flowers, and red, raisin–sized fruits are used medicinally in various cultures. It is considered a major herb of the Ayurvedic system of health and healing which has been practiced in India for more than 2000 years.

Ashwaganda is an adaptogen, which is a substance that non–specifically enhances the body’s ability to resist disease, revitalize and increase performance. In India, this herb is celebrated as an adaptogen that will do the following: boost strength, increase stamina and relieve fatigue, strengthen the immune system, speed recovery from chronic illness, soothe and calm without producing drowsiness, clarify the mind and improve memory, and slow the aging process. It is one of the most frequently used remedies in India. Because Ashwaganda has a sedative effect on the central nervous system, it is also used in Chinese medicine for cases of nervousness, insomnia, and rheumatic pains.

It is clear that ashwaganda contains biologically active compounds that are responsible for the healing effects of this herb. However, these compounds have not yet been clearly identified. Nonetheless, this herb is time tested in the eastern cultures and has proven to have many important healing effects. Laboratory studies continue to be done in an effort to more clearly understand this beneficial herb.

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Ashwaganda, by itself is an amazing herb with many health benefits. But, in Agel EXO, it represents only a part of the wonderful ensemble of 14 exotic fruits and herbs from around the world.

The Aronia berry is just one of 14 different exotic fruits and herbs contained in Agel EXO that is loaded with these important antioxidants.

References

1: Owais M, Sharad KS, Shehbaz A, Saleemuddin M. Phytomedicine. 2005 Mar;12(3):229-35.

2: Agarwal R, Diwanay S, Patki P, Patwardhan B. J Ethnopharmacol. 1999 Oct;67(1):27-35.

3: Mishra LC, Singh BB, Dagenais S. Altern Med Rev. 2000 Aug;5(4):334-46. Review.

Bilberry

As we continue to explore the wonderful health benefits of the 14 different exotic fruits and herbs in Agel EXO, it becomes increasingly more exciting to realize how truly unique it is. Today, let’s explore the bilberry.

Bilberry (Vaccinium myrtillus) is a shrubby perennial bush that is commonly found in Europe, western Asia and in North America. The bilberry bears edible fruits that are related to the American blueberry, the cranberry and also the huckleberry. In fact, it is commonly called the “European blueberry.”

For centuries, European herbalists have been using the Bilberry to treat a myriad of health related ailments, including urinary tract infections, diarrhea, night blindness, and many others. Of particular interest is the prolific use of the bilberry during World War II when British Royal Air Force pilots noticed a significant improvement in their night vision capabilities after consuming bilberry preserves prior to going out on bombing missions. Subsequent research has shown that bilberries are very powerful antioxidants, and it is in part because of this valuable property that they have such wonderful medicinal capabilities. In modern times, the bilberry has become a very popular nutritional supplement and it has been found helpful in treating various vision related problems, including poor night vision, cataracts and macular degeneration.

Researchers who have looked into the bilberry have identified the anthocyanins which are found abundantly in the bilberry as the substance responsible for most of the medicinal properties of this exotic fruit. Anthocyanins are very potent antioxidants and they appear to play a very important role in maintaining the integrity of our blood vessels, both large and very small. They appear to help prevent atherosclerosis (clogging of the arteries) in many of our vital organs. It is for this reason that they may be so beneficial in preventing

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heart disease, in helping with visual ailments, and in preventing some of the debilitating consequences of chronic diseases such as diabetes.

The bilberry is just one of 14 different exotic fruits and herbs contained in Agel EXO, each with its own repertoire of health enhancing properties.

References

1: Faria A, Oliveira J, Neves P, Gameiro P, Santos-Buelga C, de Freitas V, Mateus N. J Agric Food Chem. 2005 Aug 24;53(17):6896-6902.

2: Ramirez MR, Izquierdo I, Raseira MD, Zuanazzi JA, Barros D, Henriques AT. Pharmacol Res. 2005 Aug 9;

3: Kramer JH. Surv Ophthalmol. 2004 Nov-Dec;49(6):618;

Blueberry

The Blueberry (Vaccinium angustifolium) is very closely related to the Bilberry of northern Europe and to the Cranberry of North America. It is one of the few fruits native to North America. It has been used by the native Americans for centuries as a tasty food source and as a medicinal aid. Like it’s relatives, the blueberry is a rich source of the phenolic antioxidant called anthocyanin, as well as potassium, calcium, vitamins A, C, and E, folic acid, and fiber. It is reported by researchers at the USDA Human Nutrition Center (HNRCA) that blueberries have higher antioxidant capacity than 40 other fresh fruits and vegetables.

Recent animal research indicates that blueberries may be beneficial in slowing the process of age-related mental decline, possibly a result of the high antioxidant capacity of the anthocyanins that are so prevalent in this fruit. Also a result of this important compound, blueberries may help reduce the build up LDL (“bad” cholesterol) and thus help prevent heart disease and strokes. Also like its close relative, the bilberry, the blueberry may play a role in improving eyesight and reducing eye strain.

Just like many of the Vaccinium berries (bilberry, cranberry) the blueberry contains another biologically active substance called resveratrol. This compound has been found to suppress tumor cell proliferation and induce apoptosis (programmed tumor cell death) in selected cancer cell lines. Resveratrol also has anti-inflammatory and antioxidant properties as well.

Although the blueberry is not a cure–all, it does contain biologically important substances may help us to live better and healthier lives. It is an important component of Agel EXO, and it contributes synergistically with the other 13 exotic fruits and herbs to create a supplement with exceptional health–enhancing properties.

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References

1: Wang Y, Chang CF, Chou J, Chen HL, Deng X, Harvey BK, Cadet JL, Bickford PC. Exp Neurol. 2005 May;193(1):75-84.

2: Joseph JA, Shukitt-Hale B, Casadesus G. Am J Clin Nutr. 2005 Jan;81(1 Suppl):313S-316S. Review.

3: Kay CD, Holub BJ. Br J Nutr. 2002 Oct;88(4):389-98.

Cranberry Extract

The North American Cranberry (Vaccinium macrocarpon) has a long and distinguished history. Not only has it been a food source, but has been used in ceremonies and for medicinal purposes. Cranberries are packed with nutrients and have been extensively researched. Cranberries have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Cranberries contain proanthocyanidin compounds which prevent bacteria from attaching to the uroepithelial cells in the urinary tract.

Cranberries not only contain antioxidants but have anti-cancer and anti-inflammatory properties as well. Cranberries contain powerful phenolic antioxidants like anthocyanins, specifically it is the quercetin glycosides that provide cranberries with their free radical scavenging and enzyme inhibiting actions. The phenol antioxidants have also been shown to increase HDL (the “good” cholesterol) and reduce the oxidation of LDL (the “bad” cholesterol) potentially decreasing the risk of atherosclerosis. Resveratrol is an anti-cancer compound that is found naturally in cranberries. Resveratrol has been found to suppress tumor cell proliferation and induce apoptosis (programmed tumor cell death) in selected cancer cell lines. Resveratrol also has anti-inflammatory and anti-oxidative properties as well.

Cranberries are paced with nutrients and are an excellent source of antioxidants. Agel EXO, users can take advantage of the powerful antioxidant properties along with the benefits of 13 other exotic fruits and herbs from around the world.

Reference

1: Duthie SJ, Jenkinson AM, Crozier A, Mullen W, Pirie L, Kyle J, Yap LS, Christen P, Duthie GG. Eur J Nutr. 2005 Jul 20;

2: Gettman MT, Ogan K, Brinkley LJ, Adams-Huet B, Pak CY, Pearle MS. J Urol. 2005 Aug;174(2):590-4; quiz 801.

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3: Crews WD Jr, Harrison DW, Griffin ML, Addison K, Yount AM, Giovenco MA, Hazell J. J Altern Complement Med. 2005 Apr;11(2):305-9.

Dark Grape

References

1: Puiggros F, Llopiz N, Ardevol A, Blade C, Arola L, Salvado MJ. J Agric Food Chem. 2005 Jul 27;53(15):6080-6.

2: Jung KJ, Wallig MA, Singletary KW. Cancer Lett. 2005 May 5;

3: Chou EJ, Keevil JG, Aeschlimann S, Wiebe DA, Folts JD, Stein JH. Am J Cardiol. 2001 Sep 1;88(5):553-5.

Noni

Noni (Morinda citrifola) is an evergreen plant that is native to Malaysia, Australia, and Polynesia. There is reference to its use as a healing botanical in ancient Sanskrit Ayurvedic (traditional medicine in India) medical texts dating back thousands of years. It has been used to treat many different health disorders over the same period in multiple cultures, and it is only recently that its biologically active components have been identified and its healing properties have been explained.

In the Noni fruit, scientists have identified significant quanities of a precursor (proxeronine) to the pharmacologically active substance called xeronine. The proxeronine is ingested as part of the fruit and is converted to xeronine in the digestive tract and is subsequently absorbed into the body. Xeronine is believed to play a significant role in the proper synthesis and function of proteins that are crucial to the health of each our body’s cells. Generally speaking, this molecule has an influence on multiple organ systems within our bodies and therefore can affect the proper function of multiple cellular processes that all contribute to our overall health. As a result, the list of ailments that have been treated by the Noni fruit for thousands of years is long and comprehensive. For this reason, the noni fruit is considered by some cultures to be a “cure all” for most health related complaints. Certainly, in our sophisticated, technologically advanced society, it is difficult to make that claim. However, it is clear based on millennia of experience that the noni fruit has some important healing properties.

Noni, by itself is an amazing fruit with many health benefits. But, in Agel EXO, it represents only a part of the wonderful ensemble of 14 exotic fruits and herbs from around the world.

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References

1: Langford J, Doughty A, Wang M, Clayton L, Babich M. J Altern Complement Med. 2004 Oct;10(5):737-9.

2: McClatchey W. Integr Cancer Ther. 2002 Jun;1(2):110-20; discussion 120. Review.

3: Hirazumi A, Furusawa E. Phytother Res. 1999 Aug;13(5):380-7.

Pomegranate

The Pomegranate (Punica granatum) has an extensive history as a medicinal fruit. The first historical evidence of pomegranate trees being planted dates back as far as 3000 BC. It has legendary medicinal properties that have made it the subject of numerous myths, epics and works of art from renowned artists including Raphael, Cezanne, Homer, and even Shakespeare. In multiple regions of the world, this wonderful fruit has been revered as a symbol of health, fertility and of rebirth. It is native to the Middle Eastern region of the world, but through the ages has become a popular agricultural product all over the globe.

The pomegranate fruit is a valuable source of potassium, vitamin C and of polyphenols. It is likely a result of the excellent antioxidant capacity of the polyphenols that the pomegranate has been given such wide acclaim through the ages. As modern day science has demonstrated time and time again, antioxidants are valuable adjuncts to healthy living. They are attributed to the reduction and prevention of coronary artery disease (clogging of the heart vessels), and even the prevention of some of the biological processes that cause cancer and aging.

The pomegranate has a great history as a health-enhancing fruit. And yet, it is but one of the 14 wonderful exotic fruits and herbs that make Agel EXO an outstanding antioxidant gel.

References

1: Fuhrman B, Volkova N, Aviram M. J Nutr Biochem. 2005 Sep;16(9):570-6.

2: Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. J Nutr Biochem. 2005 Jun;16(6):360-7.

3: Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. J Med Food. 2004 Fall;7(3):305-8.

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Rooibos

Last week, we highlighted the excellent health benefits of Agel EXO. It is a very effective blend of 14 highly concentrated exotic fruit juices, purees and plant extracts coming from countries across the globe. Individually they have excellent antioxidant capacities, and when combined, the result is an extraordinary antioxidant supplement. This week, we want to explore one of the individual herbs that make up this formulation. Let’s talk about Rooibos.

Rooibos is a shrub that is indigenous to the mountains of South Africa’s Western Cape. More than 300 years ago, the inhabitants of those mountains started collecting Rooibos leaves and used them for making tea. During the past 3 centuries, Rooibos tea has been used in various cultures for many different medicinal purposes. It contains many natural antioxidants, and unlike black tea, it does not contain caffeine and has a very low tannin content. Technically speaking, Rooibos is loaded with polyphenols (flavinoids and phenolic acids). It is, in large part, the high content of these antioxidants that give it the qualities that make it a very useful herb in the treatment of many different ailments. In addition to helping counteract the oxidative stresses of contemporary life, many South African herbalists use it to help curb anxiety and even help with insomnia as it presumably affects the metabolism of one of the brain messengers (acetylcholine). In other cultures, it is used to treat allergies, as it seems to interfere with histamine. In addition, it is used to treat infant colic, as it tends to have anti-spasmodic properties in the intestines.

Roobios is a wonderful herb in its own right. Now, with Agel EXO, we can enjoy its unique antioxidant properties in combination with 13 other fruits and herbs from all around the world.

References

1: Ulicna O, Vancova O, Bozek P, Carsky J, Sebekova K, Boor P, Nakano M, Greksak M. Physiol Res. 2005 May 24;

2: Ulicna O, Greksak M, Vancova O, Zlatos L, Galbavy S, Bozek P, Nakano M. Physiol Res. 2003;52(4):461-6.

3: Kunishiro K, Tai A, Yamamoto I. Biosci Biotechnol Biochem. 2001 Oct;65(10):2137-45.

Wolfberry

References

1: Zhang M, Chen H, Huang J, Li Z, Zhu C, Zhang S. Life Sci. 2005 Mar 18;76(18):2115-24.

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2: Zhao H, Alexeev A, Chang E, Greenburg G, Bojanowski K. Phytomedicine. 2005 Jan;12(1-2):131-7.

3: Gan L, Hua Zhang S, Liang Yang X, Bi Xu H. Int Immunopharmacol. 2004 Apr;4(4):563-9.

Wolfberry References 1: Wu SJ, Ng LT, Lin CC. Phytother Res. 2004 Dec;18(12):1008-12.

2: Hai-Yang G, Ping S, Li JI, Chang-Hong X, Fu T. J Exp Ther Oncol. 2004 Oct;4(3):181-7.

3: Cheng CY, Chung WY, Szeto YT, Benzie IF. Br J Nutr. 2005 Jan;93(1):123-30.

4: Du G, Liu L, Fang J. J Huazhong Univ Sci Technolog Med Sci. 2004;24(5):518-20, 527.

5: Ha KT, Yoon SJ, Choi DY, Kim DW, Kim JK, Kim CH. J Ethnopharmacol. 2005 Jan 15;96(3):529-35.

6: Luo Q, Cai Y, Yan J, Sun M, Corke H. Life Sci. 2004 Nov 26;76(2):137-49.

7: Gan L, Zhang SH, Liu Q, Xu HB. At Eur J Pharmacol. 2003 Jun 27;471(3):217-22.

8: Luo Q, Yan J, Zhang S. Wei Sheng Yan Jiu. 2000 Mar 30;29(2):115-7. Chinese.

9: Luo Q, Yan J, Zhang S. Zhong Yao Cai. 1999 May;22(5):246-9. Chinese.

10: Li G, Yang J, Ren B, Wang Z. Wei Sheng Yan Jiu. 2002 Feb;31(1):30-1. Chinese.

Rooibos References 1: Lee EJ, Jang HD. Biofactors. 2004;21(1-4):285-92.

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2: Kucharska J, Ulicna O, Gvozdjakova A, Sumbalova Z, Vancova O, Bozek P, Nakano M, Greksak M. Physiol Res. 2004;53(5):515-21.

3: Bramati L, Aquilano F, Pietta P. J Agric Food Chem. 2003 Dec 3;51(25):7472-4.

4: Bramati L, Minoggio M, Gardana C, Simonetti P, Mauri P, Pietta P. J Agric Food Chem. 2002 Sep 25;50(20):5513-9.

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1: Wang Y, Chang CF, Chou J, Chen HL, Deng X, Harvey BK, Cadet JL, Bickford PC. Exp Neurol. 2005 May;193(1):75-84.

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2: Ramirez MR, Izquierdo I, Raseira MD, Zuanazzi JA, Barros D, Henriques AT. Pharmacol Res. 2005 Aug 9;

3: Kramer JH. Surv Ophthalmol. 2004 Nov-Dec;49(6):618;

4: Cicero AF, Derosa G, Gaddi A. Acta Diabetol. 2004 Sep;41(3):91-8. Review.

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5: Ichiyanagi T, Hatano Y, Matsuo S, Konishi T. Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1312-5.

6: Blodi BA. Insight. 2004 Jan-Mar;29(1):15-6; quiz 17-8. Review.

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8: Canter PH, Ernst E. Surv Ophthalmol. 2004 Jan-Feb;49(1):38-50. Review.

9: Erlund I, Marniemi J, Hakala P, Alfthan G, Meririnne E, Aro A. Eur J Clin Nutr. 2003 Jan;57(1):37-42.

10: Muth ER, Laurent JM, Jasper P. Altern Med Rev. 2000 Apr;5(2):164-73.

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2: Agarwal R, Diwanay S, Patki P, Patwardhan B. J Ethnopharmacol. 1999 Oct;67(1):27-35.

3: Mishra LC, Singh BB, Dagenais S. Altern Med Rev. 2000 Aug;5(4):334-46. Review.

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5: Kaur K, Rani G, Widodo N, Nagpal A, Taira K, Kaul SC, Wadhwa R. Food Chem Toxicol. 2004 Dec;42(12):2015-20.

6: Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Phytomedicine. 2000 Dec;7(6):463-9.

7: Bucci LR. Am J Clin Nutr. 2000 Aug;72(2 Suppl):624S-36S. Review.

8: Panda S, Kar A. Indian J Physiol Pharmacol. 1997 Oct;41(4):424-6.

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9: Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. J Ethnopharmacol. 1996 Feb;50(2):69-76.

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2: Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA. J Agric Food Chem. 2004 Oct 6;52(20):6122-8.

3: Zheng W, Wang SY. J Agric Food Chem. 2003 Jan 15;51(2):502-9.

4: Valcheva-Kuzmanova S, Borisova P, Galunska B, Krasnaliev I, Belcheva A. Exp Toxicol Pathol. 2004 Dec;56(3):195-201.

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6: Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Nutr Cancer. 2003;46(2):186-96.

7: Kowalczyk E, Kopff A, Niedworok J, Kopff M, Jankowski A. Kardiol Pol. 2002 Oct;57(10):332-6. English, Polish.

8: Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM. Folia Med (Plovdiv). 2002;44(3):20-3.

9: Kahkonen MP, Hopia AI, Heinonen M. J Agric Food Chem. 2001 Aug;49(8):4076-82.

10: Borissova P, Valcheva S, Belcheva A. Acta Physiol Pharmacol Bulg. 1994;20(1):25-30.

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Aloe Vera References 1: Su CK, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J, Koong A, Goffinet D, Le QT. Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):171-7.

2: Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS. Aliment Pharmacol Ther. 2004 Apr 1;19(7):739-47.

3: Langmead L, Makins RJ, Rampton DS. Aliment Pharmacol Ther. 2004 Mar 1;19(5):521-7.

4: Yagi A, Takeo S. Yakugaku Zasshi. 2003 Jul;123(7):517-32. Review. Japanese.

5: Ikeno Y, Hubbard GB, Lee S, Yu BP, Herlihy JT. Phytother Res. 2002 Dec;16(8):712-8.

6: Vogler BK, Ernst E. Br J Gen Pract. 1999 Oct;49(447):823-8. Review.

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8: Kim HS, Lee BM. Carcinogenesis. 1997 Apr;18(4):771-6.

9: Ajabnoor MA. J Ethnopharmacol. 1990 Feb;28(2):215-20.

10: Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing. Oral and topical activity of Aloe vera. J Am Podiatr Med Assoc. 1989 Nov;79(11):559-62.

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3: Visentainer JV, Vieira OA, Matsushita M, de Souza NE. Arch Latinoam Nutr. 1998 Sep;48(3):256-9.


5: Hanamura T, Hagiwara T, Kawagishi H. M Biosci Biotechnol Biochem. 2005 Feb;69(2):280-6.

6: Motohashi N, Wakabayashi H, Kurihara T, Fukushima H, Yamada T, Kawase M,Sohara Y, Tani S, Shirataki Y, Sakagami H, Satoh K, Nakashima H, Molnar A, Spengler G, Gyemant N, Ugocsai K, Molnar J. Phytother Res. 2004 Mar;18(3):212-23.

7: Wakabayashi H, Fukushima H, Yamada T, Kawase M, Shirataki Y, Satoh K, Tobe T, Hashimoto K, Kurihara T, Motohashi N, Sakagami H. Anticancer Res. 2003 Jul-Aug;23(4):3237-41.


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3: Del Pozo-Insfran D, Brenes CH, Talcott ST. J Agric Food Chem. 2004 Mar 24;52(6):1539-45.

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4: Murrieta RSS, Dufour DL, Siqueira AD; Human Ecol. 1999, 27: 455-475.

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Agel's newest product, UMI, offers a vast array of health benefits that have only really been appreciated by coastal communities with abundant access to brown seaweed. The active ingredient in UMI is Fucoidan, which is a component of brown seaweed. For centuries, brown seaweed has been considered a natural source of healthy food and nutrition. But, it has only been recently that further research has identified Fucoidan, a sulfated polysaccharide, as the true source of the health and wellness benefits of this oceanic wonder. Fucoidan has piqued the interest of many scientists and researchers as one of the ocean's greatest treasures. However, as scientists have continued to explore this complex molecule, more and more of its health benefits have been identified.

Fucoidan is like a closely guarded secret kept by those coastal societies that have enjoyed the wonderful health benefits of the Fucoidan polysaccharide for centuries.

With Agel UMI, the secret is out. This new gelceutical that delivers Fucoidan in a good tasting gel brings the amazing health benefits of this potent polysaccharide to the rest of the world where seaweed is not a common part of the every day diet. It is encouraging that now everybody can enjoy healthier living as a result of Agel UMI.

Agel UMI Benefits In many parts of the world, seaweed is not a regular part of the daily diet. In fact, there are many people who would not even consider eating seaweed. However, with Agel UMI, the exceptional health benefits of this oceanic treasure are now available to the masses. So, what is it about the brown seaweed that is so extraordinary? Through extensive research, scientists have identified a complex sulfated polysaccharide, called fucoidan as the active ingredient. Its primary makeup consists of an essential sugar called fucose along with other elements such as xylose, mannose, and galactose, and glucose. Studies consistently show that fucoidan possesses a wide range of properties beneficial to maintaining optimal health.

One of the primary ways in which Fucoidan provides a vast array of health benefits is its ability to interact with, and modulate the immune system. Several studies have identified many of the immune modulating effects of Fucoidan.1 2 The ability of a substance to modulate the immune system is an extremely useful property. Modulation is a term used to describe the process of reducing the extremes of cellular activity – either stimulation or inhibition. Immune modulating substances have the ability to increase immune function when it is depressed, such as in conditions like chronic fatigue, and then to reduce it when it is over-stimulated, such as in auto-immune diseases like lupus or rheumatoid arthritis.

Most immune modulating agents work by improving inter-cellular communication. One way cells interact and communicate is by presenting glycoproteins on their surface. Glycoproteins are complex information-rich macromolecules composed of a protein core to which is bound arrays of linked saccharides or sugars (polysaccharides). The structures of the saccharides vary and therefore relay different codes for different messages. For

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example, one message might tell a cell to secrete a specific cellular product, and another message might tell a cell when to divide. Other cells have corresponding glycoprotein receptor molecules, which can then read these messages and respond accordingly. Thus, our bodies are involved in a very sophisticated and harmonious intercellular communication all the time.

The immune system depends heavily on this kind of communication to co-ordinate cellular defense, apoptosis, cell attack and repair processes. When any of the range of saccharides required to build competent glycoproteins (and thereby convey an accurate message) are missing, the quality of that communication is compromised. It has been shown that dietary supply of certain saccharides improves the integrity of glycoprotein production. Fucoidans provide an abundant supply of Fucose, one of the necessary saccharides, and smaller amounts of several other required sugars. This is likely to be one mechanism by which the fucoidans exert their immunomodulatory effect.

Now, with this understanding of glycoprotiens, and intercellular communication, let’s specifically identify the ways in which Fucoidan has been shown to be of significant benefit for health and wellness.

References

1: Antibacterial and immunomodulating activity of fucoidan, Zapopozhets TS, Besednova NN, Loenko IuN. Antibiot Khimioter. 1995 Feb;40(2):9-13.

2: Immunostimulating and anticoagulating activity of fucoidan from brown algae Fucus evanescens of Okhotskoe sea. Kuznetsova TA, Zaporozhets TS, Besednova NN, et al. Antibiot Khimioter. 2003;48(4):11-3.

Regenerate Cells and Increase Life Span

Much of the research that has been done on fucoidan has been focused on its ability to regenerate cells. Studies have shown that fucoidan helps support mobilization of stem cells that enable the body to replace dead cells thereby enabling tissue and organ regeneration.3 In addition, fucoidan helps slow symptoms of the aging process. In study after study, fucoidan has shown itself to be beneficial in the fight for a longer, healthier life.

References

3: Sulfated Glycans Induce Rapid Hematopoietic Progenitor Cells Mobilization: Evidence for Selectin-dependent and Independent Mechanisms. Frenette PS, Weiss L. Blood, 2000 Oct 1 96(7):2460-8

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Support the Circulatory System & Health Functions

Fucoidan has also been shown to help maintain healthy blood flow and cardiac functions—thereby supporting the circulatory system.4 5 6 7 Increased blood flow helps all of our organs work more efficiently and helps us to feel better and healthier.8 Efficient functioning of our vital organs can help us prolong the effects of “wear and tear” of the normal aging process. Additionally, one study suggested that fucoidan helps to slow the absorption rate of glucose, or sugar, into the blood stream. A slower absorption rate leads to a more regulated blood sugar level.

References

4: Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia. McCaffrey TA, Falcone DJ, Borth W, Brayton CF, Weksler BB. Biochem Biophys Res Commun. 1992 Apr 30;184(2):773-81.

5: Fibrinolytic and anticoagulant activities of highly sulfated Fucoidan. Soeda S, Sakaguchi S, Shimeno H, Nagamatsu A. Biochem Pharmacol. 1992 Apr 15;43(8):1853-8.

6: Potential Antioxidant Capacity of Sulfated Polysasccharides From the Edible Brown Seaweed Fucus Vesiculosus. Ruperez P. Ahrazern O. Leal JA Agrie Food Chem. 2002 Feb 13;50(4):840-5

7: Anticoagulant properties of a Fucoidan fraction. Colliec S, Fischer AM, Tapon-Bretaudiere J, Boisson C, Durrand P, Jozefonvicz J. Thromb Res. 1991 Oct 15;64(2):143-54.

8: Intravascular granulocyte aggregates caused by the selectin-binding carbohydrate fucoidan in pig kidneys. Dittrich S, Lippek F, Gratopp A, Grosse-Siestrup C, Lange PE, Buhrer C. Clin Exp Pharmacol Physiol. 2002 Oct; 29 (10): 909-14

Maintain Healthy Cholesterol Levels

The process of cholesterol formation is in the liver. Our bodies produce a “good” cholesterol (HDL) and a “bad” cholesterol (LDL). Optimum health is achieved when we can maintain lower levels of the LDL, and sufficient levels of the HDL. There is some evidence to suggest that fucoidan can help us to maintain healthy levels of cholesterol by influencing the metabolic activity in the liver where fatty acids are processed.9 In addition, because fucoidan is a dietary fiber, it absorbs cholesterols contained in foods allowing them to be discharged from the body. This suppresses cholesterol elevations related to dietary intake of foods high in cholesterol.

References

9: Hepatic fatty acid oxidation enzyme activities are stimulated in rats fed the brown seaweed. Murata, M. et al. Journal of Nutrition, 1999 Jan:29(1):146-51.

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Help Support Healthy Joint Functions

For many of us in the United States and throughout the world, healthy joints and cartilage are daily concerns. Arthritis and joint pain can be a bothersome and sometimes debilitating. Among its many properties, fucoidan has been hailed as a natural answer to joint health. Fucoidan supports proper joint functions and cartilage health by modulating some of our body’s inflammatory and immune processes.10 11 12

References

10: Effects of the anti-inflammatory compounds castanospermine, mannose-6-phosphate and fucoidan on allograft rejection and elicited peritoneal exudates. Bartlett MR, Warren HS, Cowden WB Parish CR Immunol Cell Biol. 1994 Oct; 72(5):367-74

11: Immunomodulating activity of arabinogalactan and Fucoidan in vitro. Choi EM, Kim AJ, Kim YO, Hwang JK. J Med Food. 2005 Winter;8(4):446-53.

12: Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis. Senni K, Gueniche F, Foucault-Bertaud A, Igondjo-Tchen S, Fioretti F, Colliec-Jouault S, Durand P, Guezennec J, Godeau G, Letourneur D. Arch Biochem Biophys. 2006 Jan 1;445(1):56-64.

Assist in Inducing the Elimination of Harmful Cells

Fucoidan may also prove helpful in eliminating harmful cells, including those that are related to some cancers. This is accomplished through a process called apoptosis. Apoptosis is technical term for the process of a cell “bursting” and therefore dying. Sulphated polysaccharides like fucoidan have been shown to assist in inducing apoptosis, which is a natural process where living organisms eliminate harmful cells and render the genetic blueprint (DNA) of harmful cells useless.13 14 15 16 Additionally, some research suggests that fucoidan may have an effect on cancer growth by suppressing the generation of new blood vessels around cancer cells, cutting off their nutrient supply.

References

13: Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida. Maruvama H, Tamauchi H, Hashimoto M, Nakano T. In Vivo. 2003 May-Jun;17(3):245-9

14: Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Itoh H. Noda H, Amano H, Zhuang C, MizunoT, Ito H Anticancer Res. 1993 Nov-Dec;13(6A):2045-52

15: Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell

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leukemia cells. Haneji K, Matsuda T, Tomita M, Kawakami H, Ohshiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N. Nutr Cancer. 2005;52(2):189-201.

16: Antitumor and antiproliferative effects of fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Riou D, Colliec-Jouault S, Pnczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P, Roussakis C. Anticancer Res. 1996 May-Jun;16(3A):1213-8.

Help Maintain a Strong Immune System

Fucoidan supports the immune system in a number of different ways. Some research suggests that it may cause an increase in the number of circulating mature white blood cells in the body, which are an integral part of the body’s natural immune system.17 The findings from other studies suggest that fucoidan supports the immune system by improving phagocytosis and activating other important immune responses. These processes act together to destroy bacteria, viruses and other foreign particles by multiple blood “scavenger” cells.18 19 20 21

References


18: Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii). Zhuang C. et al. Biosci Biotechnol Biochem, 1995 Apr:59(4):563-7.

19: Antibacterial and immunomodulating activity of Fucoidan. Zapopozhets TS, Besednova NN, Loenko IuN. Anitbiot Khimoioter. 1995 Feb;40(2):9-13.

20: Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Baba M, Nakajima M, Schols D, Pauwels R, Balzarini J, De Clercq E. Antiviral Res. 1988 Sep;9(6):335-43.

21: Anitviral properties of Fucoidan fractions from Leathesia difformis. Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damont EB. Phytomedicine. 1999 Nov;6(5):335-40.

Promotes Optimal Gastrointestinal Health

The number of people suffering from gastric diseases is rapidly increasing around the world as more and more people are consuming foods with more fat content and less dietary fiber. Once in the stomach, fucoidan attaches to the stomach lining where it has a protective effect. In addition, it stimulates the stomach lining to regulate the inflammatory process and also to “self-repair” damaged tissue. Fucoidan, because of its immune promoting and inflammation modulating activity, is a tremendous aid in maintaining proper gastrointestinal function and health.22

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References

22: Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells, Matsumoto S.,Nagaoka M, Hara T. Kimura-Takagi I, Mistsuvama K. Clinical and Experimental Immunology. June 2004, vol. 136, no.3 pp. 432-439(8)

Increase Energy & Support Respiratory Functions

Fucoidan supports immunological abilities by assisting the body in the production of interferon-Y and interleukin-12 while supporting normal respiratory functions.23

References

23: The Polysaccharide Fucoidan Inhibits the Antibiotic-induced Inflammatory Cascade in Experimental Pneumococcal Meningitis, Granert C. Raud J, Lindquist L, Clinical and Diagnostic Laboratory Immunology, May 1998, 5(3): 322-4

Detoxify the Body and Help Rid The Body of Free Radicals

The deleterious effect of free radicals on our bodies is well documented. The beneficial effect of antioxidants in helping to neutralize the oxidative stresses placed upon our organs and metabolic processes is also very clear. Fucoidan has a long list of health and wellness properties, not the least of which is that it also is a rich supply of antioxidants.24

References

24: Potential Antioxidant Capacity of Sulphated Polysaccharides From the Edible Brown Seaweed Fucus Vesiculosus. Ruperez P, Ahrazem O, Leal JA. Agric Food Chem. 2002 Feb 13; 50(4):840-5

Promotes Kidney Health

The kidneys serve as the “waste disposal system” for our bodies. Therefore, the proper function of our kidneys is vital to our overall health and wellbeing. There are numerous studies in the literature to suggest that fucoidan may play a significant roll in maintaining optimal kidney function.25 26 27 28

References

25: Intravascular granulocyte aggregates caused by the selectin-¬binding carbohydrate fucoidan in pig kidneys. Dittrich S, Lippek F, Gratopp A. Grosse-Siestrup C, Lange PE. Buhrer C, Clin Exp Pharmacol Physiol. 2002 Oct 29(10):909-14

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26: Protective effects of inhibiting both blood and vascular selectins after stroke and reperfusion. Ruehl ML, Orozco JA, Stoker MB, McDonagh PF, Coull BM, Ritter LS. Neurol Res. 2002 Apr;24(3):226-32.

27: Effects of Fucoidan on chronic renal failure in rats. Zhang Q, Li Z, Xu Z, Niu X, Zhang H. Planta Med. 2003 Jun;69(6):537-41.

28: Fucoidan inhibits the development of proteinuria in active Heymann nephritis. Zhang Q, Li N, Zhao T, Qi H, Xu Z, Li Z. Phytother Res. 2005 Jan;19(1):50-3

Supports Vibrant Health & Vitality

Fucoidan supports the body against “complement activation” believed to play an adverse role in chronic degenerative symptoms like atherosclerosis, myocardial infarction, alzheimer’s disease and other conditions associated with aging.29

The literature is plentiful supporting the fact that fucoidan is a valuable resource for maintaining optimal health. The brown algae harvested from the earth’s ocean are truly one of the most valuable gifts of the great deep. And Agel has harnessed this power into a single gelceutical—UMI.

References

29: Effects of C-reactive protein and pentosan polysulphate on human complement activation. Klegeris A. Singh EA. McGerr PL Immunology 2002 Jul;106(3):381-8

UMI References 1: Antibacterial and immunomodulating activity of fucoidan, Zapopozhets TS, Besednova NN, Loenko IuN. Antibiot Khimioter. 1995 Feb;40(2):9-13.

2: Immunostimulating and anticoagulating activity of fucoidan from brown algae Fucus evanescens of Okhotskoe sea. Kuznetsova TA, Zaporozhets TS, Besednova NN, et al. Antibiot Khimioter. 2003;48(4):11-3.

3: Sulfated Glycans Induce Rapid Hematopoietic Progenitor Cells Mobilization: Evidence for Selectin-dependent and Independent Mechanisms. Frenette PS, Weiss L. Blood, 2000 Oct 1 96(7):2460-8

4: Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia. McCaffrey TA, Falcone DJ, Borth W, Brayton CF, Weksler BB. Biochem Biophys Res Commun. 1992 Apr 30;184(2):773-81.

5: Fibrinolytic and anticoagulant activities of highly sulfated Fucoidan. Soeda S, Sakaguchi S, Shimeno H, Nagamatsu A. Biochem Pharmacol. 1992 Apr 15;43(8):1853-8.

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6: Potential Antioxidant Capacity of Sulfated Polysasccharides From the Edible Brown Seaweed Fucus Vesiculosus. Ruperez P. Ahrazern O. Leal JA Agrie Food Chem. 2002 Feb 13;50(4):840-5

7: Anticoagulant properties of a Fucoidan fraction. Colliec S, Fischer AM, Tapon-Bretaudiere J, Boisson C, Durrand P, Jozefonvicz J. Thromb Res. 1991 Oct 15;64(2):143-54.

8: Intravascular granulocyte aggregates caused by the selectin-binding carbohydrate fucoidan in pig kidneys. Dittrich S, Lippek F, Gratopp A, Grosse-Siestrup C, Lange PE, Buhrer C. Clin Exp Pharmacol Physiol. 2002 Oct; 29 (10): 909-14

9: Hepatic fatty acid oxidation enzyme activities are stimulated in rats fed the brown seaweed. Murata, M. et al. Journal of Nutrition, 1999 Jan:29(1):146-51.

10: Effects of the anti-inflammatory compounds castanospermine, mannose-6-phosphate and fucoidan on allograft rejection and elicited peritoneal exudates. Bartlett MR, Warren HS, Cowden WB Parish CR Immunol Cell Biol. 1994 Oct; 72(5):367-74

11: Immunomodulating activity of arabinogalactan and Fucoidan in vitro. Choi EM, Kim AJ, Kim YO, Hwang JK. J Med Food. 2005 Winter;8(4):446-53.

12: Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis. Senni K, Gueniche F, Foucault-Bertaud A, Igondjo-Tchen S, Fioretti F, Colliec-Jouault S, Durand P, Guezennec J, Godeau G, Letourneur D. Arch Biochem Biophys. 2006 Jan 1;445(1):56-64.

13: Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida. Maruvama H, Tamauchi H, Hashimoto M, Nakano T. In Vivo. 2003 May-Jun;17(3):245-9


15: Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Haneji K, Matsuda T, Tomita M, Kawakami H, Ohshiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N. Nutr Cancer. 2005;52(2):189-201.

16: Antitumor and antiproliferative effects of fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Riou D, Colliec-Jouault S, Pnczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P, Roussakis C. Anticancer Res. 1996 May-Jun;16(3A):1213-8.

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18: Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii). Zhuang C. et al. Biosci Biotechnol Biochem, 1995 Apr:59(4):563-7.

19: Antibacterial and immunomodulating activity of Fucoidan. Zapopozhets TS, Besednova NN, Loenko IuN. Anitbiot Khimoioter. 1995 Feb;40(2):9-13.

20: Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Baba M, Nakajima M, Schols D, Pauwels R, Balzarini J, De Clercq E. Antiviral Res. 1988 Sep;9(6):335-43.

21: Anitviral properties of Fucoidan fractions from Leathesia difformis. Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damont EB. Phytomedicine. 1999 Nov;6(5):335-40.

22: Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells, Matsumoto S.,Nagaoka M, Hara T. Kimura-Takagi I, Mistsuvama K. Clinical and Experimental Immunology. June 2004, vol. 136, no.3 pp. 432-439(8)

23: The Polysaccharide Fucoidan Inhibits the Antibiotic-induced Inflammatory Cascade in Experimental Pneumococcal Meningitis, Granert C. Raud J, Lindquist L, Clinical and Diagnostic Laboratory Immunology, May 1998, 5(3): 322-4

24: Potential Antioxidant Capacity of Sulphated Polysaccharides From the Edible Brown Seaweed Fucus Vesiculosus. Ruperez P, Ahrazem O, Leal JA. Agric Food Chem. 2002 Feb 13; 50(4):840-5

25: Intravascular granulocyte aggregates caused by the selectin-¬binding carbohydrate fucoidan in pig kidneys. Dittrich S, Lippek F, Gratopp A. Grosse-Siestrup C, Lange PE. Buhrer C, Clin Exp Pharmacol Physiol. 2002 Oct 29(10):909-14

26: Protective effects of inhibiting both blood and vascular selectins after stroke and reperfusion. Ruehl ML, Orozco JA, Stoker MB, McDonagh PF, Coull BM, Ritter LS. Neurol Res. 2002 Apr;24(3):226-32.

27: Effects of Fucoidan on chronic renal failure in rats. Zhang Q, Li Z, Xu Z, Niu X, Zhang H. Planta Med. 2003 Jun;69(6):537-41.

28: Fucoidan inhibits the development of proteinuria in active Heymann nephritis. Zhang Q, Li N, Zhao T, Qi H, Xu Z, Li Z. Phytother Res. 2005 Jan;19(1):50-3

29: Effects of C-reactive protein and pentosan polysulphate on human complement activation. Klegeris A. Singh EA. McGerr PL Immunology 2002 Jul;106(3):381-8

Agel MIN

Agel MIN 1

Vitamins and Minerals are essential tools in everyday human physiology. They function as coenzymes and cofactors that are involved in almost all biochemical processes in the body. In essence, vitamins and minerals are crucial to healthy living.

Before the days of “fast food” and “empty” calories, these vitamins and minerals were found naturally in our food. However, in modern days, as the average diet consists mostly of processed, manufactured food, there is overwhelming scientific evidence to support the intake of dietary supplements that are rich in vitamins and minerals [1-5].

Agel MIN is a proprietary formulation of vitamins and minerals that provides 100% of the RDI (Recommended Daily Intake) of almost all the essential vitamins and as much as 50% of the RDI of most of the essential minerals. More importantly, the bioavailability of these vitamins and minerals is enhanced due to the revolutionary gel technology employed in the MIN formulation. The vitamins and minerals are either dissolved or suspended in the gel, resulting in immediate availability for absorption by the digestive tract. In addition, the minerals used in the formulation of MIN are Albion™ Chelates. Albion Laboratories, Inc. is the world’s major producer of patented amino acid chelated minerals. Albion’s patented chelation processes bind minerals to amino acids, markedly increasing their bioavailability.

There are some who advocate using mega doses of various vitamins, presuming that if some is good, more is better. However, there is growing scientific evidence that too much of a good thing can be harmful [6-7]. Therefore, Agel’s formulation for a moderate dose of readily available vitamins and minerals is ideal.

MIN: StaMINa and Ageless Zest Agel™ MIN is the Gelceutical™ designed to nourish your stamina and deliver zesty health. MIN contains required daily levels of 12 essential vitamins and high levels of 11 essential minerals. MIN helps you get more energy from your food, and then stores these energy reserves to provide stamina. In addition, MIN’s essential vitamins and minerals sustain of over 5000 vital biofunctions to deliver vigor, drive, well-being and ageless zest.

MIN Health Benefits

StaMINa™

Stamina is defined as the complete physical and cognitive energy required for an active lifestyle. Unfortunately, many people lack stamina. They seem to “walk into a wall”. MIN contains 12 essential vitamins and 11 essential minerals to maintain your stamina. Increased stamina is obtained from MIN by providing essential nutrients that 1) generate stamina energy from food and 2) create an efficient biochemistry throughout the body.

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StaMINa Generation

Vitamins and minerals are closely involved in the processes of converting food into energy. They are cofactors of enzymes that efficiently generate biochemical energy from carbohydrates, fats and proteins in the diet. Increased efficiency equals increased energy.

StaMINa = Energy Reserves

Trillions of biochemical reactions take place every second within the body to maintain vigor, wellness and gusto. Every biochemical reaction requires energy. Essential vitamins and minerals work with biocatalytic enzymes that minimize the energy necessary for each biochemical reaction. Multiply trillions of reactions over thousands of seconds each day equal substantial energy reserves. These energy reserves provide stamina. Therefore, vitamins and minerals save energy — helping the body biochemistry to run efficiently. Stamina is the result of efficiency.

Ageless Zest™

Regardless of age, the body should feel zest. Zest is a drive to live, feeling vim & vigor, and a state of good health regardless of one’s chronological age. Ageless Zest is a composite of thousands and thousands of properly functioning biochemical reactions within the body. These biochemical reactions allow over 5000 functions within the body to maintain overall health, vigor, vim and vitality. Ageless Zest may be associated with vision, joints, bones, teeth, hair, smell, taste, hearing, touch, immune functions, heart, lungs, gastrointestinal, nerves, brain, muscles, tendons, cartilage, hormones, reproduction, pregnancy, respiration, coordination, etc. Falling levels of any one or more essential vitamins or minerals can create instabilities with some of the over 5000 functions – resulting in loss of zest, drive, spirit and vivacity. MIN’s essential vitamins and minerals help maintain necessary micronutrient levels to ensure stability of over 5000 biofunctions. Ageless Zest is A-Z health.

Who and When

MIN is recommended for healthy adults, teenagers, children and athletes. Consume MIN at the same time every day. Consume one Agel MIN packet a day. Endurance athletes may consume a second MIN packet for stamina.

Precautions

Pregnant or nursing women should consult with their physician concerning the MIN formula.

Those who need MIN’s StaMINa and Ageless Zest

• Unable to finish tasks • Tired of life

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• Without drive to work • Lacking vim and vigor • Why don’t I feel enthusiastic? • Always feel tired • No get-up-and-go • Frequently feel sick • Wish I had more sick-days • Loss of spirit to innovate • Poor physical condition • I’m feeling my age • Less enthusiasm • Feeling older every day • Life is too complicated • Wishing to be more successful • My kids are always sick • Where to people get all that stamina? • My drive to work slows down by afternoon • There is no “dash” to my step • Feeling “over-the-hill”

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Agel MIN - Essential Vitamin Ingredients Vitamin A (Retinol, Retinal & Retinoic acid)

an essential fat-soluble vitamin. Vitamin A’s precursor is beta-carotene, a member of the antioxidant carotenoid family, is transported by retinol-binding protein to its destinations. Vitamin A is essential for proper vision, protein synthesis, cell differentiation, reproduction and growth. Vitamin A is found in dark leafy greens (spinach & broccoli) and yellow/orange vegetables & fruits (carrots, cantaloupe, winter squash, pumpkin, mango, - not corn or banana). Early signs of Vitamin A deficiency include anemia, bone weakness, joint pain, cracked teeth and frequent tooth decay.

Vitamin D (Calciferol)

an essential fat-soluble vitamin. Vitamin D can be synthesized by the body (with adequate exposure to sunlight) in connection with previtamin D3. The active form of Vitamin D (calcitriol) is a messenger that signals calcium-availability for bone growth. Vitamin D, A, C & K, along with minerals calcium, phosphorus & magnesium are essential for bone growth. Vitamin D is found in fortified milk, fortified margarine and butter; as well as synthesized by UV sunlight exposure. Early signs of Vitamin D deficiency include bone weakness (rickets) and bone brittleness (osteoporosis).

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Vitamin E (Tocopherol)

an essential fat-soluble vitamin. Vitamin E is a powerful fat-soluble antioxidant that protects cell wall fluidity and nutrient transport. Vitamin E antioxidant is recharged by Vitamin C. Vitamin E is found in vegetable oils, olive oil, leafy green vegetables, whole grains, nuts and seeds. Early signs of Vitamin E deficiency include fatigue, leg cramps, blurred vision, nausea, anemia, loss in muscle coordination and impaired speech.

Vitamin C (Ascorbic acid)

an essential water-soluble vitamin. Vitamin C is a powerful antioxidant against free radicals and is helpful for neurotransmitters synthesis (helping with coordination). Vitamin C helps you receive energy by efficiently metabolizing amino acids (from protein). Vitamin C is found in citrus, berries, fruits, & green vegetables. Early signs of deficiency are usually in elderly, alcoholics, and infants. Vitamin C may guard against colds and help your immune system.

Vitamin B1 (Thiamin)

an essential water-soluble B-vitamin. Thiamin is an enzyme cofactor (with TPP) for efficient conversion of protein, carbohydrate and fat into energy. Thiamin is important for proper functioning of nerve membranes. It is needed for the metabolism of many sugars. Thiamin is found in whole grains, meats, greens & beans. Early signs of deficiency are depression, muscle weakness (after only 10 days), apathy, confusion, irritability and rapid degeneration of nervous system activity.

Vitamin B2 (Riboflavin)

an essential water-soluble B-vitamin. Riboflavin is an enzyme cofactor (with FAD and FMN) for many energy metabolism reactions involving dietary proteins, carbohydrates and fats. Riboflavin is found in dark, green, leafy vegetables & dairy products. Early signs of deficiency are that minor injuries do not heal because new cells cannot replace old cells, confusion, greasy skin, inflammation of the eyes, lips, or tongue.

Vitamin B3 (Niacin)

an essential water-soluble B-vitamin. Niacin is an enzyme cofactor (with NAD and NADP) for rapid metabolism of protein, carbohydrate and fat to energy in every cell. Niacin is found in dairy products, meats & whole grains. Early signs of B3 deficiency are fatigue, decreased appetite, indigestion that can lead to diarrhea, dermatitis, dementia and death.

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Vitamin B5 (Pantothenic acid)

an essential water-soluble B-vitamin. Pantothenic acid is an enzyme cofactor (with CoA) for energy metabolism from all food sources. Pantothenic acid is found in meats, mushrooms, broccoli and whole grains. Early signs of deficiency include fatigue, vomiting, nausea, stomach cramps, insomnia, depression, irritability and apathy.

Vitamin B6 (Pyridoxine)

an essential water-soluble B-vitamin. Pyridoxine is an enzyme cofactor (with PLP & PMP) converting amino acids & fatty acids into energy. Some pyridoxine can be stored in muscle tissue. Vitamin B6 influences immune system activity and cognitive performance. Vitamin B6 is found in bananas, potatoes, chicken, fish, and meats. Early signs of B6 deficiency include anemia, depression, confusion, fatigue, headaches, nerve damage and dermatitis.

Vitamin B12 (Cobalamin)

an essential water-soluble B-vitamin. Vitamin B12 activates folate activity and is activated by folate. Vitamin B12 helps DNA synthesis for new cells, protects nerve cells, and promotes normal growth & bone cell activity. B12 found in meats & dairy products. Early signs of B12 deficiency include fatigue, hypersensitivity of skin, anemia, sore tongue & degeneration of nerves.

Folate

an essential water-soluble vitamin. Folate is an enzyme cofactor (with THF and DHF) that is essential for regeneration. It activates vitamin B12, helps in the synthesis of DNA and is essential for new growth. Folate is essential for pregnant women. Folate (from the word foliage) is found in asparagus, green leafy vegetables, grains, beans, peas, oranges and avocados. Early signs of Folate deficiency include irritability, fatigue, confusion, headache, anemia and gastrointestinal deterioration. Folate deficiencies occur when there is a high demand for new cell synthesis: pregnancy, cancer, burns, measles and blood loss.

Biotin

an essential water-soluble vitamin. Biotin is necessary for proper functioning of the energy-producing TCA Cycle. Biotin is found in soybeans, egg yolks, whole grains, fish and organ meats. Early signs of Biotin deficiency include skin rash, depression, lethargy, numb/tingling sensation in arms/legs, hair loss and fatigue.

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Agel MIN Essential Mineral Ingredients Calcium

an essential macromineral. Calcium, the most abundant mineral in the body, is essential for the strength and growth of skeletal bones and teeth. Calcium contributes to muscle contractions, blood clotting, nerve impulse transmission and hormone secretion. Calcium is found in water, milk, milk products, tofu, broccoli, watercress & cauliflower. Early signs of calcium deficiency include bone weakness, brittle bones, cracked teeth and fatigue.

Phosphorus

an essential macromineral. Phosphorus, the second most abundant body mineral, is essential for bone strength, bone growth and teeth strength. Phosphorus is part of all energy reactions in the body, is a key component of DNA and RNA (cell growth) and is integral in phospholipids that control protein-activation cell nutrition. Phosphorus is found in all meat sources, beans, seeds, nuts, milk and milk products. Early signs of phosphorus deficiency include demineralization of bones and teeth, bone weakness, fatigue and lethargy.

Iodine

an essential mineral. Iodine is the key nutrient of the thyroid gland that regulates body metabolism, body temperature, growth, reproduction, nerve growth and muscle function. Iodine is found mainly from iodized table salt, sea salt, sea-grown plants (seaweed) and animal life (seafood). Early signs of iodine deficiency include low metabolism, fatigue, lack of initiative and eventually goiter (enlargement of thyroid gland in throat).

Magnesium

an essential macromineral. Most magnesium reserves are bound in bone and teeth. Magnesium is a common enzyme cofactor in facilitating efficient biochemical reactions. Magnesium is necessary for muscle contraction, blood clotting, regulating blood pressure, metabolism of food to energy and for immune system health. Magnesium is found in water, nuts, whole grains, green leafy vegetables, chocolate and seafood. Early signs of magnesium deficiency are weakness, confusion, bizarre muscle movements, difficulty swallowing and fatigue.

Zinc

an essential macromineral. Zinc is a very common metalloenzyme cofactor that is intrinsically involved in generating energy from food. Zinc, in conjunction with calcium and magnesium, are essential for bone growth and bone strength. Zinc also affects blood

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clotting, thyroid hormone function, insulin activity, activates Vitamin A, wound healing, fetal development and influences learning and behavior. Zinc is found in protein-rich foods (meat, poultry and seafoods), beans, peas and whole-grains.

Selenium

an essential micromineral. Selenium is a powerful antioxidant that also part of the enzyme glutathione peroxidase. Selenium and Vitamin E work in antioxidant synergy. Selenium is needed for proper thyroid (metabolism) function. Selenium is found as a trace mineral in many fruits and vegetables; as well as in meat and seafood. Signs of selenium deficiency include fatigue and heart diseases.

Copper

an essential micromineral. Copper is a common cofactor with many enzymes (metalloenzymes) to generate maximum energy from the food you eat. Copper is found in beans, peas, whole grains, nuts, seafood and drinking water. Copper deficiency is rare, but can be implicated with high blood cholesterol, genetic disorders, anemia and bone abnormalities.

Manganese

an essential micromineral. Manganese is a common enzyme cofactor (metalloenzymes); working with many enzymes to efficiently converts food into energy. Manganese is typically stored in bone, liver and kidneys. Manganese is found in nuts, whole grains and leafy vegetables.

Chromium

an essential micromineral. Chromium enhances insulin action, is involved in the conversion of carbohydrate and fat into energy. Chromium is found in meats, nuts and vegetable oils. Chromium deficiency can lead to diabetic-type inability to metabolize glucose normally.

Molybdenum

an essential micromineral. Molybdenum is a cofactor for several metalloenzymes to convert food into energy. Molybdenum is found in legumes, leafy green vegetables, milk, whole grains and milk products.

Vanadium

a trace mineral. Vanadium is involved in normalizing blood glucose, strengthening teeth and bones. Vanadium is found in grains, mushrooms and seafood.

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Inositol

a key portion of phospholipids that make up cell membranes. Inositol allows for proper neurotransmission, metabolic regulation and normal growth. Inositol is found in seafood (krill).

References

1: Fairfield KM, Fletcher RH, Vitamins for Chronic Disease Prevention in Adults: Scientific Review, JAMA, 2002 Jun 19; 287(23): p. 3116-3124.

2: Stampfer, M.J. and E.B. Rimm, Epidemiologic evidence for vitamin E in prevention of cardiovascular disease. Am J Clin Nutr, 1995. 62(6 Suppl): p. 1365S-1369S.

3: Rimm, E.B. and M.J. Stampfer, The role of antioxidants in preventive cardiology. Curr Opin Cardiol, 1997. 12(2): p. 188-94.

1: Schunemann, H.J., et al., The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population. Am J Respir Crit Care Med, 2001. 163(5): p. 1246-55.

2: McKay, D.L., et al., The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet. J Am Coll Nutr, 2000. 19(5): p. 613-21.

3: Brown, B.G., et al., Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med, 2001. 345(22): p. 1583-92.

4: Kushi, L.H., et al., Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med, 1996. 334(18): p. 1156-62.

Agel OHM

Agel OHM 1

The fast–paced environment of everyday living is stressful and at times overwhelming. Lacking the nutrients to provide both sustained energy and that “burst of energy” often needed, modern diets frequently require supplements to fill the gap.

Agel OHM, is a blend of vitamins, minerals, and herbs that complements a proper diet and regular exercise to support the body by providing the “extra energy” required to meet everyday demands. It does not rely upon chemical stimulants like caffeine or ephedra. Rather, it looks to a B–complex vitamin–based formula that acts as a coenzyme to facilitate the body’s own metabolic processes required to convert carbohydrates into energy. Panax Ginseng is included, a strong antioxidant helping the body to resist stressful influences. Panax Ginseng has also been associated with beneficial effects on motor performance, cognitive behavior and overall Quality of Life. Likewise, OHM contains Rhodiola rosea to help improve physical endurance and mental performance, and to reduce stress-induced fatigue in humans. Schizandra, grown in China and Korea is another premium herb found in OHM, used historically and today to help improve concentration, strength, stamina, endurance, and alertness, without causing nervousness like caffeine related stimulants.

Although nothing can replace a healthy diet and regular physical activity, Agel OHM may be an excellent source of additional energy during a stressful day.

Agel OHM Benefits Agel™ OHM is the Gelceutical™ designed to boost your energy when you are feeling tired, fatigued or lazy. An added benefit of OHM is to provide focus when you are lacking motivation or stressed by life’s circumstances. Therefore, OHM can be summed up in 2 words: 1) energy and 2) focus.

Health Benefits Energy Increased energy is obtained from OHM by providing key nutrients that either 1) generate more energy from your food or 2) are direct sources of energy to the body. The first category (helping to generate energy from food) is a collection of water–soluble B–vitamins. B–vitamins are enzyme cofactors that generate more energy from your diet of carbohydrates, fats and proteins. The second category (direct sources of energy) is D–ribose. D–ribose is the quick energy the body uses for bursts of speed.

Focus There are 3 natural herbal ingredients that help provide you focus. Helping to reduce stress, provide feelings of motivation, increase cognitive functions (memory & learning), and enhance physical work & endurance can be wrapped up in a single word – focus. These benefits are provided by the synergistic action of Schizandra fruit, Ginseng root and Rhodiola root.

Agel OHM

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Who and When Recommended for healthy adults (including older teenagers) and athletes. Consume during the morning or afternoon (for those who sleep at night). Consume one Agel OHM packet a day. Some individuals may want to “rip ‘n’ sip” two packets in a day when energy levels are extremely low.

Precautions Not recommended for children or pregnant/nursing women. Those with very high blood pressure or high intracranial pressure should use caution. May cause sleeplessness if consumed too soon before bedtime.

Signs of Low-Energy and Lack of Focus • Afternoon fatigue • Lack of daily focus • Doing low-priority tasks first • Tired after a full night’s sleep • Eating too much junk food • Easily cross or angry • Complain about lack of energy • Complain about others’ energy levels’ • Move around slowly • Feel inadequate as a parent • Have to stop between flights of stairs • Eat enough, but do not feel energetic • Not motivated to work • Prefer to sit and watch TV • No zest for life • Feel stress from work or home • Feel like too many tasks to do • Feel like all tasks have equal priority • Easily stressed by the unexpected • Always feel overworked • Never feel like receiving adequate rest • Frequently sick • Have memory lapses • Problems focusing on learning • Difficulty learning new concepts

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Agel OHM

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Agel OHM Ingredients Vitamin C (Ascorbic acid) an essential water-soluble vitamin, a powerful antioxidant against free radicals, is helpful for neurotransmitters synthesis (helping with coordination) Vitamin C helps you receive energy by efficiently metabolizing amino acids (from protein). Vitamin C is found in citrus, berries, fruits, & green vegetables. Early signs of deficiency are usually in elderly, alcoholics, and infants. Vitamin C may guard against colds and help your immune system.

Vitamin B1 an essential water-soluble B-vitamin. Thiamin is an enzyme cofactor (with TPP) for efficient conversion of protein, carbohydrate and fat into energy. Thiamin is important for proper functioning of nerve membranes. It is needed for the metabolism of many sugars. Thiamin is found in whole grains, meats, greens & beans. Early signs of deficiency are depression, muscle weakness (after only 10 days), apathy, confusion, irritability and rapid degeneration of nervous system activity.

Vitamin B2 (Riboflavin) an essential water-soluble B-vitamin. Riboflavin is an enzyme cofactor (with FAD and FMN) for many energy metabolism reactions involving dietary proteins, carbohydrates and fats. Riboflavin is found in dark, green, leafy vegetables & dairy products. Early signs of deficiency are that minor injuries do not heal because new cells cannot replace old cells, confusion, greasy skin, inflammation of the eyes, lips, or tongue.

Vitamin B3 (Niacin) an essential water-soluble B-vitamin. Niacin is an enzyme cofactor (with NAD and NADP) for rapid metabolism of protein, carbohydrate and fat to energy in every cell. Niacin is found in dairy products, meats & whole grains. Early signs of B3 deficiency are fatigue, decreased appetite, indigestion that can lead to diarrhea, dermatitis, dementia and death.

Vitamin B5 (Pantothenic acid) an essential water-soluble B-vitamin. Pantothenic acid is an enzyme cofactor (with CoA) for energy metabolism from all food sources. Pantothenic acid is found in meats, mushrooms, broccoli and whole grains. Early signs of deficiency include fatigue, vomiting, nausea, stomach cramps, insomnia, depression, irritability and apathy.

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Vitamin B6 (Pyridoxine) an essential water-soluble B-vitamin. Pyridoxine is an enzyme cofactor (with PLP & PMP) converting amino acids & fatty acids into energy. Some pyridoxine can be stored in muscle tissue. Vitamin B6 influences immune system activity and cognitive performance. Vitamin B6 is found in bananas, potatoes, chicken, fish, and meats. Early signs of B6 deficiency include anemia, depression, confusion, fatigue, headaches, nerve damage and dermatitis.

Vitamin B12 (Cobalamin) an essential water-soluble B-vitamin. Vitamin B12 activates folate activity and is activated by folate. Vitamin B12 helps DNA synthesis for new cells, protects nerve cells, and promotes normal growth & bone cell activity. B12 found in meats & dairy products. Early signs of B12 deficiency include fatigue, hypersensitivity of skin, anemia, sore tongue & degeneration of nerves.

Chromium an essential mineral. Chromium enhances insulin action, is involved in the conversion of carbohydrate and fat into energy. Chromium is found in meats, nuts and vegetable oils.

Vanadium a trace mineral. Vanadium is involved in normalizing blood glucose, strengthening teeth and bones. Vanadium is found in grains, mushrooms and seafood.

Inositol a key portion of phospholipids that make up cell membranes. Inositol allows for proper neurotransmission, metabolic regulation and normal growth. Inositol is found in seafood (krill).

Taurine a semi-essential amino acid. Taurine is necessary for metabolism - energy production. Taurine helps in normal functioning of heart muscle, skeletal muscle, white blood cells & the central nervous system. Taurine is found in dairy products, meats and fish.

D-ribose an integral part of DNA and RNA. D-ribose is “instant energy”, “liquid energy”, the body’s own form of quick energy.

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Focus Ingredients Schizandra fruit mdash; In China, Schizandra fruit, Schizandra chinensis, is known as wu–wei–zi meaning “five taste fruit” (sweet, salty, spicy, sour and bitter). Schizandra is a nutritional food source in Asia where people eat a couple of dried berries every day to enhance their energy levels. Traditional use of Schizandra in China helped build wei–chi, the defense energy of the body to resist infection. Scientific studies demonstrate its use to rebuild liver tissue, help improve work performance, build strength and reduce fatigue. In China, berries are chewed for 100 days to improve physical coordination and mental concentration. Schizandra berries enhance oxygen usage, thereby improving overall endurance during times of stress, study and work.

References

1: Anjia C, Cunhong L, Wenhua G, Zhide H, Xingguo C. Biomed Chromatogr. 2005 Sep;19(7):481-7.

2: Opletal L, Krenkova M, Havlickova P. Ceska Slov Farm. 2001 Jul;50(4):173-80. Review. Czech.

3: Wang JP, Raung SL, Hsu MF, Chen CC. Br J Pharmacol. 1994 Nov;113(3):945-53.

Ginseng root Ginseng root, Panax ginseng, has been used for millennia in Asia as a tonic for health, long–ife and vitality. Ginseng research shows cognitive benefits, immune health and reduced signs of stress. Ginseng improves cognitive performance, secondary memory performance, speed of performing memory tasks, attentiveness and auditory reaction time. Korean Ginseng supports immune system health by increasing antibody levels (the guardian soldiers of the immune system) and increasing activity of natural killer cells (the exploding bombs of immune system). Ginseng helps reduce signs of stress by increasing accuracy of attention–priority tasks, facial recognition and improved social functioning. Ginseng helps you focus by supporting mental concentration, enhancing learning and by maintaining consistent, long–term health.

References

1: Bentler SE, Hartz AJ, Kuhn EM. J Clin Psychiatry. 2005 May;66(5):625-32.

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2: Kaneko H, Nakanishi K. J Pharmacol Sci. 2004 Jun;95(2):158-62. Review.

3: Hartz AJ, Bentler S, Noyes R, Hoehns J, Logemann C, Sinift S, Butani Y, Wang W, Brake K, Ernst M, Kautzman H.Psychol Med. 2004 Jan;34(1):51-61.

Rhodiola root Rhodiola, Rodiola rosea, grows in the northern portions of Europe and Russia. Rhodiola root “possesses a clear anti-fatigue effect without any reported adverse reactions or side-effects when used in a situation of moderate levels of fatigue and stress”. Rhodiola helps reduce signs of stress, enhances physical work & endurance, and helps to minimize the effects of fatigue “under nearly realistic work situations”. Rhodiola increases beta-endorphins (helping you relax and feel good) and neurotransmitters by nourishing the cerebral cortex, brain stem and hypothalamus.

References

1: De Bock K, Eijnde BO, Ramaekers M, Hespel P. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.

2: Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Phytomedicine. 2000 Oct;7(5):365-71.

3: Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. Phytomedicine. 2000 Apr;7(2):85-9.

Ginseng References 2: Song Z, Moser C, Wu H, Larsen MW, Johansen HK, Faber V, Kharazmi A, Hoiby N. Ugeskr Laeger. 2005 Aug 15;167(33):3054-6. Danish.

9: Tohda C, Kuboyama T, Komatsu K. Neurosignals. 2005;14(1-2):34-45.

13: Goulet ED, Dionne IJ. Int J Sport Nutr Exerc Metab. 2005 Feb;15(1):75-83. Review.

78: Lee JY, Kim JW, Cho SD, Kim YH, Choi KJ, Joo WH, Cho YK, Moon JY. Life Sci. 2004 Aug 13;75(13):1621-34.

84: Cho J, Park W, Lee S, Ahn W, Lee Y. J Clin Endocrinol Metab. 2004 Jul;89(7):3510-5.

91: Hasegawa H. J Pharmacol Sci. 2004 Jun;95(2):153-7. Review.

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93: Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A. Arch Gerontol Geriatr Suppl. 2004;(9):69-73.

117: Block KI, Mead MN. Integr Cancer Ther. 2003 Sep;2(3):247-67. Review.

151: Persson J, Bringlov E, Nilsson LG, Nyberg L. Psychopharmacology (Berl). 2004 Apr;172(4):430-4. Epub 2003 Nov 25.

164: Kim SH, Park KS. Pharmacol Res. 2003 Nov;48(5):511-3.

Schizandra References 1: Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T. Drug Metab Dispos. 2004 Dec;32(12):1351-8. Epub 2004 Sep 1.

2: Huang L, Chen L, Zhang Z. Zhong Yao Cai. 2004 Mar;27(3):202-3. Chinese.

3: Lee YJ, Cho JY, Kim JH, Park WK, Kim DK, Rhyu MR. Biol Pharm Bull. 2004 Jul;27(7):1066-9.

4: Kim SR, Lee MK, Koo KA, Kim SH, Sung SH, Lee NG, Markelonis GJ, Oh TH, Yang JH, Kim YC. J Neurosci Res. 2004 May 1;76(3):397-405.

5: Sterbova H, Sevcikova P, Kvasnickova L, Glatz Z, Slanina J. Electrophoresis. 2002 Jan;23(2):253-8.

6: Opletal L, Krenkova M, Havlickova P. Ceska Slov Farm. 2001 Sep;50(5):219-24. Czech.

7: Zhu M, Lin KF, Yeung RY, Li RC. J Ethnopharmacol. 1999 Oct;67(1):61-8.

8: Li PC, Poon KT, Ko KM. Am J Chin Med. 1996;24(3-4):255-62.

9: Wang K, Tong YY, Song WZ. Yao Xue Xue Bao. 1990;25(1):49-53. Chinese.

10: Tong YY, Song WZ. Zhongguo Zhong Yao Za Zhi. 1989 Oct;14(10):611-4, 639-40. Chinese.

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Rhodiola References 1: De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchiarini L, Dacha M. Biofactors. 2004;20(3):147-59.

2: Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Bull Exp Biol Med. 2003 Dec;136(6):585-7.

3: Earnest CP, Morss GM, Wyatt F, Jordan AN, Colson S, Church TS, Fitzgerald Y, Autrey L, Jurca R, Lucia A. Med Sci Sports Exerc. 2004 Mar;36(3):504-9.

4: Tolonen A, Hohtola A, Jalonen J. J Mass Spectrom. 2003 Aug;38(8):845-53.

5: Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. Phytomedicine. 2003 Mar;10(2-3):95-105.

6: Provalova NV, Skurikhin EG, Pershina OV, Suslov NI, Minakova MY, Dygai AM, Gol'dberg ED. Bull Exp Biol Med. 2002 May;133(5):428-32.

7: Kelly GS. Altern Med Rev. 2001 Jun;6(3):293-302. Review.

8: Maslova LV, Kondrat'ev BIu, Maslov LN, Lishmanov IuB. Eksp Klin Farmakol. 1994 Nov-Dec;57(6):61-3. Russian.

9: Udintsev SN, Shakhov VP. Neoplasma. 1991;38(3):323-31.

10: Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, Todorov I. Acta Physiol Pharmacol Bulg. 1986;12(1):3-16.

Agel PRO

Agel PRO 1

Agel™ PRO is one of Agel’s newest products, complementing an already compelling product line for health and vitality. PRO is a balanced protein gel that serves a wide variety of nutrition needs for a large number of people. Most people associate protein products with body builders or severe athletes. But, on the contrary, this balanced protein gel can be beneficial to practically everybody. In effect, it is useful for athletes who want to engage in severe muscle building, for individuals concerned with weight management, or simply for anybody who wants a mini-meal replacement or in-between meal snack.

Agel PRO contains 20 grams of protein in 175 calories, and it is balanced with medium chain triglycerides and fructose to help build muscle and maintain overall body conditioning, all from an inexpensive and easily carried package that actually tastes great.

Agel PRO Benefits Muscle Building

Effective muscle protein synthesis requires an adequate supply of a wide variety of amino acids. And, the more aggressive the muscle building or regeneration you are engaged in, the more of a high quality protein source you will need. In PRO, the protein source is an ultra-filtered whey protein isolate, the highest quality protein known. This ultra-filtration technology creates a protein that is complete (containing all nine essential amino acids, plus several others), easy to digest, and 90 percent pure. Whey isolate is a rich source of the critical amino acids that give athletes an edge by metabolizing directly into muscle tissue. It also is an excellent source of leucine, an essential amino acid that helps build lean muscle mass while promoting fat loss.

Weight Management

In the last two decades, there has been an increasing awareness of the long-term health benefits of achieving an optimal body composition (more muscle, less fat). Each year, experts identify more and more disease conditions that are related to being significantly overweight. In an effort to thwart this serious health threat, many health professionals and government agencies are spending hundreds of millions of dollars every year to educate us about the importance of decreasing our excessive consumption of high (but empty) calorie foods, and of increasing the amount of our daily physical activity. We are squarely faced with the global issue of a population that is becoming increasingly sedentary, overfed, and undernourished.

So…what do we do about this serious and problematic global health issue? Countless individuals are striving daily to find their own solution to losing those extra pounds, but the “battle of the bulge” can be a very frustrating problem for many. Researchers across the world have been searching for that “magic formula” that will just melt away the excess fat, but most of the proposed solutions usually contain some sort of artificial stimulant or appetite suppressant such as the infamous phen-phen, or the more commonly used ingredients such as caffeine and ephedrine. These ingredients have resulted in some

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health related problems that are as life-threatening as the extra body fat itself. In fact, these three popular ingredients have resulted in some significant life-threatening conditions, such as heart valve damage, heart attacks, and strokes. In reality, the achievement of an optimal body composition requires a series of proactive lifestyle choices. It requires obedience to a simple law of nature…balancing the quantity and quality of calories consumed with the quantity of calories burned. In simple terms, we have to eat fewer calories, eat smarter, and move more.

What exactly does it mean to be eating smarter and fewer calories? Why all the “mumbo jumbo?” Calories are a way of measuring the energy potential of a food. Certain foods produce more energy than others when metabolized or “burned” by your cells. Food has three basic components; proteins, carbohydrates and fats, and all three of these components play an important role in sustaining your cellular activities. In addition, your body metabolizes each of these components differently. Proteins are broken down into smaller building blocks called amino acids, carbohydrates are broken down into energy-rich simple sugars, and fats are broken down into smaller fatty acids. All of these are subsequently taken up into your body to be used as energy or to be incorporated into the appropriate cellular structures. Because each of these smaller components can be turned into energy, they represent calories. And, in very simple terms, if you consume more calories (proteins, carbohydrates, fats) than your body needs, your body is genetically programmed to store those calories as fat for later use as a means of preparing itself for times of “famine.” As you are likely aware, your body has a very efficient way of converting extra calories into stored body fat, especially if you are not getting enough activity or exercise during the day.

So, let’s talk about how calories go out. We burn calories at rest, during daily living activity, and when we exercise. Each of us has a basal metabolic rate (BMR). BMR is the minimum caloric requirement needed to sustain life in a resting individual. This is the amount of energy your body would burn if you slept all day (24 hours). Therefore, while you are at rest, your body has a basic energy requirement or BMR that is governed by many factors, but mostly based on your individual body composition (fat to lean-mass ratio). Simply stated, muscle burns more calories than fat does even while you are at rest. So if your lean-mass ratio is higher, then your metabolic rate is generally higher. If your fat ratio is higher, then your metabolic rate is lower and you don’t burn as many calories at rest. The key to success in burning more calories at rest is to have a higher lean mass ratio, which can be accomplished through resistance or strength training exercises and through optimal nutrition. Therefore, the optimal body composition, very generally stated, is to have a lower body fat content and more muscle content. In fact, according to the some nutrition experts, the optimum body fat content is between 5%-15% for males and between 12%-20% for females. In summary, a higher ratio of muscle mass results in a higher metabolism, whereas a higher ratio of fat mass results in the opposite. It is important to note that some body fat is not all bad. In fact, you need body fat for a variety of important physiological reasons. But, in excess amounts, it can be problematic. This is because with more body fat, your body needs fewer calories to function, and therefore you store more of your food calories as fat, thus perpetuating the original problem.

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But, what if there was a way to facilitate, from a nutritional standpoint, this seemingly simple, yet sometimes difficult process of balancing the calories in with calories out in order to achieve optimal body composition? In contrast to the harmful stimulants described above, researchers have identified supplemental methods that can be helpful in this process. They have identified naturally occurring compounds that, when combined with physical activity, can help you to increase lean muscle mass and consequently help your body burn calories more efficiently. With more lean muscle mass, you have a higher BMR, a more efficient metabolism, and improved body composition.

Unfortunately, many people who are trying to manage their weight are just counting total calories. While that is really the essence of weight management and optimal body composition, there is more and more research suggesting that simply counting calories is not the entire formula. It is perhaps even more important to consume more frequent, smaller servings of a meal or snack that have a balance of calories from all three macronutrient sources: protein, carbohydrate, and fat. Unfortunately, many diets and weight management programs overemphasize a single macronutrient as being the only “solution.” But, the true solution is balance, and getting that balance throughout the day. Just as you need to have an optimal lean mass to fat ratio in your body composition, you also need to have a favorable balance of carbohydrates, fats and proteins in your meals and snacks. This can get rather tricky, but nonetheless is very important to consider.

How does this all work? Every time you ingest food, you send numerous signals to your body. A meal with high levels of carbohydrates signals the secretion of insulin, a fat storage hormone (messenger). At the same time, the carbohydrates are broken down into the simple sugars, and a whole mechanism of enzymes and cellular processes are activated in an effort to generate immediate energy. Additionally, some of the sugars are stored for later use in the form of glycogen, a rapid release form of energy. However, those sugars that are not needed for immediate energy production or for glycogen storage are then converted to fat, your body’s long-term food storage system. Thus, excess consumption of carbohydrates will lead to excessive fat storage.

A meal with a higher protein ratio, on the other hand, signals the secretion of glucagon, which can be considered the opposite of insulin – it signals your body to burn fat instead. In addition, protein breaks down into amino acids, the primary building block of enzymes and muscles. These amino acids stimulate muscle generation and repair, and they accelerate metabolism. Proteins are essential to virtually every aspect of cellular activity, and are responsible for the integrity and proper function of almost all body systems. Needless to say, we all need protein in sufficient quantities every day in our diet. At a minimum, it is recommended by nutritional experts that you get 1.0 to 1.5 grams of protein in your diet for every kilogram of body weight (.45 gm to .68 gm per pound). And, with physical exercise, stress, and sickness, your dietary protein requirements are even higher.

Then there is dietary fat. By itself, fat doesn’t have much of an affect on either insulin or glucagon, but moderate amounts of fat in your diet are healthy and necessary. Fatty acids are essential to a myriad of cellular structures and processes, including cell membranes,

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joint fluids, brain matter, and hormones, just to name a few. And, in fact, you need about 25 to 30% of your daily caloric intake to come from healthy fats in your diet. Although fats are an essential part of your diet, if you take in too much fat (which is high in calories), you create an excess of calories needed for your metabolic needs, and this triggers insulin release, which then turns on fat storage. Once again, balance and moderation is essential.

By balancing the amounts of protein, carbohydrates and fats that you ingest with your meals and snacks, and by avoiding excess caloric intake, you are helping your body store less fat and build more muscle. This is how you obtain an optimal body composition.

Why Whey Isolate?

Whey isolate is one of the finest sources of protein available for many different reasons. It is easy to digest. It contains only trace amounts of milk fat and lactose (less than 0.5%) making it easily digestible even for those with lactose intolerance. It contains over 90% pure protein. It is complete, in that it contains all nine essential amino acids, plus several additional ones including leucine, which plays a key role in building lean muscle mass and promoting fat loss (whey isolate has 50% more leucine than soy protein isolate.)7 Furthermore, whey isolate has the highest known levels of branched chain amino acids (BCAA’s) of any natural food source. BCAA’s, unlike other amino acids, are metabolized directly in the muscle tissue (instead of being metabolized in the liver). Thus, they are the first to be used during periods of exercise and training.

Why Medium-Chain Triglycerides (MCT’s)

Of the fats that make up your diet, the ones that are the healthiest and most easily digested are the medium chain triglycerides (MCT’s). In contrast, the long chain triglycerides (LCT’s) that are also present in your food are much more difficult to digest and are more easily stored as body fat. Because MCTs are easily digested, rapidly absorbed, quickly metabolized, and readily converted to energy in the body, they are not as readily deposited as body fat. For these reasons, they have been used for many years in clinical nutritional formulas to help feed those with malabsorption syndromes. MCTs contain a high amount of lauric acid, the major fatty acid from the fat of the coconut. This fatty acid has been recognized for its unique properties including its antiviral, antibacterial, and antiprotozoal functions. Also in one clinical trial with overweight men, consumption of a diet rich in MCTs resulted in greater loss of fat perhaps due to increased energy expenditure and fat oxidation observed with MCT intake. MCTs may be considered as agents that potentially stimulate weight loss.

Mini-Meal Replacement

Agel PRO can also be used as a mini-meal replacement or in-between meal snack. It is becoming increasingly clear that we should eat less in quantity for but more frequently. This alternative eating practice has many proven benefits over just eating 2-3 times per day, and ideally, you need to be eating 5-6 times per day. However, your meals and

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snacks should have fewer calories since you are eating more of them. In addition, in order to be most effective, you need to be eating meals and snacks that are balanced with the appropriate ratios of proteins, carbohydrates, and fats.

The following are just some of the many proven benefits provided by eating smaller but more frequent meals and snacks:

1. Lowered total cholesterol with improved HDL (good) to LDL (bad) ratio 2. Reduction in appetite by 27% 3. Weight loss while sparing lean mass (muscle) - in other words, fat loss 4. Fewer insulin surges from better blood sugar control 5. More normal cortisol levels (lower) - helping in better body composition

Many of us are so busy in our day-to-day lives that we don't take the time to eat often enough. A convenient and balanced between-meal protein supplement could be the answer to help you eat less, more frequently.

PRO References 1. Harvard School of Public Health website. What is Protein? 2006. http://www.hsph.harvard.edu/nutritionsource/protein.html

2. Whey Protein Report: Unabridged Edition, Assessment of average protein needs. 2006. http://www.wheyprotein.com/sec2.html

3. Ibid. A primer on protein.

4. Middleton N, Jelen P, Bell G, 2004. “Whole blood and mononuclear cell glutathione response to dietary whey protein supplementation in sedentary and trained male human subjects.” International Journ of Food Sci Nutrition 55(2):131-141.

5. Whey Protein Institute website, 2006. http://www.wheyoflife.org/facts.cfm#12

6. Blomstrand E, Saltin B, 2001. “BCAA intake affects protein metabolism inmuscle after but not during exercise in humans.” American Journal of Physiol Endocrinol Metab, 281(2):E365-E374

7. Robert Child, “The Whey Forward,” Functional Foods and Nutraceuticals, December, 2003.

8. Fabry, P., Fodor, J., Hejl, Z. Braun, T., et al. "The Frequency of Meals: Its Relation to Hypercholesterolemia and Decreased Glucose Tolerance." Lancet, 1964; 2: 614?615

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9. Jenkins, D. J. A.,Wolever, T.MS., Vuksan, V., et al. "Nibbling Versus Gorging: Metabolic Advantages of Increased Meal Frequency." New England Journal Of Medicine, 1989: 321: 929?934.

10. Powell, J.T., Franks, P.T., and Poulter, N.R. "Does Nibbling or Grazing Protect the Peripheral Arteries from Atherosclerosis?" Journal Of Cardiovascular Risk, Feb. 6, 1999 (1):19-22.

11. McGrath, S.A. and Gibney, M.J. "The Effects of Altered Frequency of Eating on Plasma Lipids in Free-living Healthy Males on Normal Self-selected Diets," European Journal Of Clinical Nutrition, June 1994 (6): 402-7

12. International Journal Of Obesity & Related Metabolic Disorders, 1999, 23 (11): 1151-9

13. Scandinavian Journal Of Medicine & Science In Sports 1998 6 (5):265-72. 14. Jenkins, D.J.A., Wolever, T.M.S., Ocana, A.M., etc al. "Metabolic Effects of Reducing Rate of Glucose Ingestion by Single Bolus Versus Continuous Sipping," Diabetes 1993, 39: 775-81

15. Titan, S.M.O., Bingham, S., Welch, A., Luben, R, etc al. "Frequency of Eating and Concentrations of Serum Cholesterol in the Norfolk Population of the European Prospective Investigation into Cancer: Cross Sectional Study. British Medical Journal December 1, 2001; 323:1286

Agel FIT

Agel FIT 1

Agel FIT is a wonderful component of the initial line-up of Agel products. This weight management aid will be a huge help to those who struggle with “the battle of the bulge.” And, because it is formulated as a gel preparation, it can easily be taken when it is most effective (see below).

We all know that being overweight is a common, frustrating problem for people in all parts of the world, and it would be wonderful if there were a magic pill that would melt away the extra pounds without any physical effort. Unfortunately, there is no “magic bullet”. Let’s face it. Losing weight involves a simple equation; the calories expended must exceed those that are consumed. In other words, we have to ‘eat a little less’ and ‘move a little more’. Now, this equation sounds easy, but the execution of a reasonable diet combined with a regular exercise program maintained over the long-term is sometimes not an easy process. Therefore, many people trying to lose weight will benefit from supplemental support as they face the inevitable obstacles along the way.

So let’s talk about Agel FIT. This great tasting gel can help play a role in this frustrating struggle, without the harmful effects of stimulants. The active ingredient in Agel FIT is a well studied, patent pending form of HCA (hydroxycitric acid), called Super CitriMax™. It comes from the extract of the fruit and rind of Garcinia combogia, and it has been shown in clinical trials to decrease body weight by reducing appetite and inhibiting fat synthesis without stimulating the central nervous system. There are other products on the market that use HCA for weight management, but not all of them contain Super CitriMax™. What makes this form of HCA so good is that it is bound to calcium and potassium, which maximizes its solubility, thereby, increasing its bioavailability. Add that to the fact that it is now suspended in a gel formulation and we have the makings of an awesome weight management aid.

Research has shown that HCA potency, bioavailability, timing of ingestion, and dosage are the essential requirements for optimal results. According to the studies, the Super CitriMax™ works best if it is ingested 30 to 60 minutes prior to eating meals, three times each day. This will allow time for the absorption of the HCA and suppression of appetite. With the convenience of a gel pack, timing the ingestion of this product in the 30 to 60 minute window will be a breeze.

The revolutionary gel technology used to deliver this formulation not only improves the bioavailability of Super CitriMax™, but also offers a convenience factor that can maximize the timing of its ingestion. Although nothing can replace a healthy diet and regular physical activity, Agel FIT will be an excellent addition to a successful weight management program.

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Agel FIT Benefits Agel’s FIT™ gel is a key component in your weight-loss and weight-maintenance goals. Nearly everyone wants to lose weight, reduce body fat and contour arms, abdomen, chest, and legs.

The Opportunity

“I want to lose weight. Now.” “I want my 6-pack abdomen back.” “I want to look good in my swim suit.” “I’ve got to get fit now!!” Ever hear yourself or someone make these comments. Our busy lives often “force” us to eat poorly. No balanced diet. Only processed foods. Eating on the run. These choices have led to an overweight and obesity pandemic that now rivals chronic diseases.

Statistics in the USA are an indicator of problems stemming from overweight and obesity. The prevalence of human overweight and obesity has increased over the years in both genders, for all age groups, for all racial groups and all educational levels. Astonishing overweight and obesity statistics abound for USA citizens. USA males overweight = 69% and females overweight = 62% should be surprising. The percentage of obese adults (BMI ≥ 30): males 28% and females 33%. Surprising? It is still on the rise.

Overweight (BMI > 25.0-29.9) statistics have shown that the 20-34 year old range has been impacted the most in the past 20 years. Males 20-34 years old in the overweight classification increased 139%, while females increased 189%.

Even more alarming over the past 20 years are the increases in obesity (BMI ≥ 30.0) among adults, with male obesity increased 217% and female obesity increased 195%.

The cost of lost productivity related to obesity (BMI ≥ 30) among Americans ages 17-64 is $3.9 billion. Workdays lost related to obesity = 39.3 million, physician office visits related to obesity = 62.7 million workdays, restricted activity days related to obesity: 239.0 million workdays.

The Solution

Agel FIT™ gel and the Agel FIT Switch™ Program can help you, your family, your friends, and your neighbors succeed with weight-loss and physical fitness. FIT contains active levels of (-)hydroxycitric acid (HCA). (-)Hydroxycitric acid acts to turn off two important biochemical “switches” - fatty acid synthesis/storage and glycogen breakdown.

There are hundreds of biological switches functioning every second within your body chemistry. Switches may be flipped “OFF” when there is abundant product concentration from a biochemical reaction. Conversely, a BioSwitch may be turn “ON” when there is abundant starting material for the reaction. These BioSwitches center around the activity

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of enzymes. Enzymes are helpful proteins that allow biochemical reactions to take place with the lowest input of energy.

Agel FIT Program GelBenefits

1. Helps curb your appetite 2. Helps you reduce food intake 3. Increases fat burning 4. Inhibits fat synthesis & storage 5. Supports body weight-loss 6. Helps balance emotional feelings 7. Is 3-times more effective than diet and exercise alone 8. Maintains healthy cholesterol levels within already normal levels 9. Reduces Body Mass Index (BMI) to healthier levels

The FIT Program

1. Agel FIT 30-60 minutes before meals (2-4 times/day) 1. Helps reduce your appetite 2. Supports fat metabolism 3. Long-lasting effects

2. Set caloric limits (2000 kcal/day) 1. Key to weight loss 2. Choose foods you like 3. Eat more Walk more

3. Eat 5-7 small meals 1. Helps maintain feeling of fullness 2. Minimizes glucose swings

4. Keep a daily journal 1. Records you feelings 2. Tracks your success 3. Balances your emotions

5. Get 30 minutes of walking each day 1. Burns more calories 2. Helps you socialize 3. Increases fitness 4. Eat more Walk more

6. Drink more water (carbonated soft drinks do not count) 1. Aids digestions 2. Supports energy levels 3. Helps feel satisfied

Agel’s FIT Features:

1. Gelceutical™ enhanced bioactive technology 2. Exclusive FIT BioSwitch™ Technology 3. Patent pending Super Citrimax® HCA

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4. Carry-anywhere Agel pouch

The Ingredients

FIT contains the extract of Garcinia cambogia, a small yellow-orange tree fruit from Southern India. Garcinia cambogia contains high concentrations of hydroxycitric acid (HCA). Agel uses the natural, active patent pending Super Citrimax™ (-)hydroxycitric acid, a concentrated water-soluble extract from Garcinia cambogia.

Agel FIT Ingredients The primary active ingredient in Agel FIT is Super CitriMax®. It is the patent pending form hydroxycitric acid (HCA) which comes from the extract of the fruit and rind of the Asian fruit called Garcinia Combogia.

HCA has been shown in clinical trials to decrease body weight by reducing appetite, inhibiting fat synthesis, and increasing fat metabolism, without artificial stimulation of the central nervous system. The HCA in Super CitriMax® is bound to calcium and potassium, which maximizes its solubility, thereby, increasing its bioavailability. Research has shown that HCA potency, bioavailability, timing of ingestion, and dosage are the essential requirements for optimal results. In addition, the safety of Super CitriMax® has been confirmed in recently published studies.

HCA has been found to produce multiple physiological effects. One of these effects is appetite suppression. Recent clinical studies show that Super CitriMax® increases levels of serotonin (5-HT) by blocking its re-uptake in the brain. This neurotransmitter has been found to play a vital role in a wide range of behavioral functions in the body, including mood, sleep and appetite control. Studies show that serotonin levels are closely related to eating behavior and body weight. There is a significant correlation between increased plasma levels of serotonin and decreased food intake, reduced weight gain and increased energy expenditure. In addition to its effect on appetite, increased serotonin levels may also play a beneficial role in helping overweight people face some of the related emotional issues, including binge-eating and depression.

HCA also inhibits the production of fatty acids by inhibiting the biochemical action of a intra cellular enzyme called ATP citrate lyase. ATP citrate lyase controls the biosynthesis of cellular Acetyl CoA (a carbohydrate-derived building block for fatty acids). Acetyl CoA is originally synthesized in the cellular mitochondria, but since the mitochondrial membrane is impermeable to Acetyl CoA, it is converted into hydroxycitrate, pumped across the mitochondrial membrane then reconverted from hydroxycitrate into Acetyl CoA and Oxaloacetate via ATP citrate lyase. However, in the presence of adequate HCA, ATP citrate lyase is deactivated, thereby blocking the synthesis of fatty acids from carbohydrates and their subsequent storage in the liver. This also prompts biochemical changes in the liver that promote fat burning. By switching this enzyme off, HCA effectively blocks the conversion of starch and sugary foods into fat, and consequently,

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HCA is known as a lipogenesis (lipo – fat, genesis – creation) inhibitor. In other words, with Super CitriMax®, fatty acid synthesis is switched off.

Super CitriMax® has also been found to have a beneficial effect on cholesterol levels. In addition to helping with weight management, Super CitriMax® has been found to lower triglycerides, LDL (bad cholesterol) and increase HDL (beneficial cholesterol).

There are many weight management products on the market that use HCA as the active ingredient. However, most of them do not use Super CitriMax.® This patent pending form of HCA is bound to the minerals calcium and potassium. Consequently, the HCA is virtually 100% soluble, and therefore more bioavailable than regular calcium-based HCA ingredients. Super CitriMax® also contains 20% more HCA than ordinary HCA products. In its new formulation, Super CitriMax® has been shown to be significantly more effective as a weight management aid than previous formulations of HCA.

Super CitriMax® in and of itself is a well-proven weight management aid. However, now that it is formulated as an integral part of Agel Fit, its true potential will be realized.

Super CitriMax®

Tomita K, Okuhara Y, Shigematsu N, Suh H, Lim K. Biosci Biotechnol Biochem. 2003 Sep;67(9):1999-2001.

Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Mol Cell Biochem. 2002 Sep;238(1-2):89-103.

Westerterp-Plantenga MS, Kovacs EM. Int J Obes Relat Metab Disord. 2002 Jun;26(6):870-2

Hydroxycitric Acid References Super CitriMax®

18: Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S. Diabetes Obes Metab. 2004 May;6(3):171-80.

41: Ohia SE, Awe SO, LeDay AM, Opere CA, Bagchi D. Res Commun Mol Pathol Pharmacol. 2001 Mar-Apr;109(3-4):210-6.

48: Loe YC, Bergeron N, Rodriguez N, Schwarz JM. Anal Biochem. 2001 May 1;292(1):148-54.

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159: Sullivan AC, Triscari J, Hamilton JG, Miller ON, Wheatley VR. Lipids. 1974 Feb;9(2):121-8.

164: Sullivan AC, Hamilton JG, Miller ON, Wheatley VR. Arch Biochem Biophys. 1972 May;150(1):183-90.

2: Downs BW, Bagchi M, Subbaraju GV, Shara MA, Preuss HG, Bagchi D. Mutat Res. 2005 Jul 27;

3: Lim K, Ryu S, Suh H, Ishihara K, Fushiki T. J Nutr Sci Vitaminol (Tokyo). 2005 Feb;51(1):1-7. Review.

6: Wielinga PY, Wachters-Hagedoorn RE, Bouter B, van Dijk TH, Stellaard F, Nieuwenhuizen AG, Verkade HJ, Scheurink AJ. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1144-9. Epub 2004 Dec 16.

28: Hayamizu K, Hirakawa H, Oikawa D, Nakanishi T, Takagi T, Tachibana T, Furuse M. Fitoterapia. 2003 Apr;74(3):267-73.

32: Leonhardt M, Langhans W. J Nutr. 2002 Jul;132(7):1977-82.

Agel FLX

Agel FLX 1

Agel™ FLX was formulated to take advantage of 4 fantastic ingredients that have all been found to be very beneficial in the maintenance of healthy joints and maximum flexibility. This formulation is a first, not only because it contains all 4 ingredients, but also because it is delivered in a gel suspension, a remarkable innovation by itself.

Joint pain and immobility associated with osteoarthritis are a problem that is increasing around the world. Tens of millions of people in the United States alone are forced to limit their activity and therefore have a hindered lifestyle as a result of poor joint health. As our population continues to age, this problem will continue to increase and therefore, so will the need to alleviate the cause and the symptoms of this painful and debilitating condition.

Osteoarthritis is the term used to describe joints that have deteriorated and become inflamed as a result of damaged cartilage. The cartilage serves as the cushion at the joint surface, and when it is damaged and worn, it becomes roughened and patchy, sometimes to the point of bone-on-bone friction. These roughened surfaces cause inflammation, subsequent pain, and a decreased range of motion of the joints. Osteoarthritis has many causes, many of them relating to extended use and abuse over the course of many years. In fact, practically everybody has, or will experience some degree of osteoarthritis at some point in their life. But, there are some physical conditions and other predisposing factors that accelerate this process including the following: obesity, poor nutrition, genetics, traumatic injury, and overuse. In fact, some people even develop some degree of joint pain and degeneration by their teenage years.

So, what are the answers to this complex problem? There are many medications available today that address only the symptoms of osteoarthritis. Most of them are known as NSAID’s or Non-steroidal Anti-inflammatory Drugs. These are more commonly known by the names of Ibuprofen, Naproxen, and Aspirin. There are also some other even more potent medications available, but a physician must prescribe them. Although frequently effective at alleviating the symptoms of osteoarthritis, the NSAID’s all have significant ill-health-related consequences with long-term use. In addition, they don’t address the underlying problem, that being the worn cartilage and damage to the joint itself. In fact, some studies show that these medications accelerate the progression of osteoarthritis.

As a result of the limitations related to the currently available medications for osteoarthritis, there has been significant research done to identify other means of addressing this condition, and better yet of preventing the premature deterioration of the joint cartilage itself. As this research has progressed, there have been some rather remarkable discoveries. Researchers have identified some of the key building blocks in our joints and cartilage and have found naturally occurring sources of them in our environment. By studying the effects of incorporating these components into our diets, scientists have found some wonderful results with regard to the improvement of joint health, and even the slowing of joint degeneration. They have concluded that by orally ingesting some of these compounds that are important factors in the regeneration and maintenance of healthy joints, we can delay the process and even improve the symptoms of osteoarthritis. That is remarkable.

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So, what are these compounds that have been found to be so helpful in maintaining healthy joints? There are four that we will address here: (a®Chondroitin, Glucosamine, MSM (MethylSulfonylMethane), and Celadrin proprietary combination of cetylated fatty acids). These four ingredients have all been found in clinical trials, individually, to improve joint function and health. They have become a mainstay and a very important ally to those who suffer from joint pain and immobility. What’s more, they have been found to slow down the process of joint deterioration, and are fast becoming a mainstay for all adults who want to maintain healthy joints and active lifestyles.

Wouldn’t it be great if there were a product available that had all 4 of these ingredients in one formulation? What kind of synergy would be present if all 4 of these natural joint health wonders were able to perform together in a single blend?

Agel FLX Benefits Chondroitin is extracted from shark or bovine cartilage. It is one of the major building blocks used in the formation and repair of the cartilage matrix. Cartilage is the tough, flexible connective tissue that serves as the cushion for the joints and is also found in other parts of the body such as the tip of the nose and outer ears. One of chondroitin’s primary functions as one of the key components in the cartilage matrix is to attract water to the other larger macromolecules within the matrix, thus keeping it soft and flexible. As such, it helps provide the cushion necessary to prevent bone-to-bone contact, especially in the weight bearing joints such as the knees and hips. In addition, the body uses chondroitin to prevent certain enzymes from breaking down the existing cartilage, thus providing a protective effect. The optimum daily dose is 1200 mg.

Glucosamine is produced from crab, lobster and shrimp shells. It is classified as an amino sugar. Unlike other forms of sugar found in the body, this form is incorporated into the structure of body tissues, rather than being used for energy. In fact, the body uses glucosamine to build your fingernails and toenails, tendons, skin, eyes, bones, ligaments and even your heart valves. But, in particular, it is found in high concentrations in your joint tissues and more specifically the cartilage matrix. Glucosamine is one of the components used in the production of Chondroitin, and in fact, it stimulates the body to produce more of this important building block for joint cartilage. As we age, our bodies decrease the natural production of Glucosamine therefore supplementation of this important joint structural component is important. The optimal daily dose is 1500 mg.

In multiple clinical trials, Glucosamine and Chondroitin have been found to work synergistically to help reduce joint degeneration and may in fact help to stimulate the regeneration of damaged cartilage.

MSM (MethylSulfonylMethane) is a naturally occurring organic sulfur compound found in many plant and animal tissues. Sulfur is an essential component of healthy hair, skin, nails, tendons, and joints. It has also been found to help detoxify the body on a cellular level, in addition to relieving pain and inflammation. MSM provides the essential sulfur

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that is necessary to build strong collagen and therefore strong and healthy cartilage by strengthening the sulfur bonds between the collagen strands. Although MSM is found in many of the foods that we eat, processing and cooking easily destroy it. As a result, MSM is probably not present in significant quantities in the majority of foods that we eat. Most people would probably benefit from supplementation of this crucial element for optimal health.

Celadrin® is a patented blend of cetylated fatty acids (CFA’s) that have been stabilized through a proprietary process of esterifying oils. This blend has been formulated to optimize the natural ability of CFA’s to alleviate pain and reduce inflammation in human tissues. In addition, the CFA’s in Celadrin® have the effect of increased joint lubrication. The prime role of Celadrin® appears to be its ability to enhance cell membrane health and integrity. As a result it halts the production of inflammatory compounds known as prostaglandins. It also reduces the production of the negative immune factors like IL-6 that also play a central role in inflammation.

The body is made up of an enormous number of cells separated into various types and functions. The cell membrane is the organized structure that separates and protects components in the cell from neighboring cells and the outside world. Some of the major components of the cell membrane are structural lipids, which regulate nutrients and other compounds across the cell membrane. This regulation is very critical to the adequate function and health of the individual cell. Celadrin® enhances the cell membrane and its integrity for efficient functionality. The result is a more efficient, fluid, permeable and a youthful cell membrane. Loss of cell membrane integrity from internal and external stressors begins a number of rapid aging processes – including uncontrolled or imbalanced inflammation. Inflammation can occur with age, dietary conditions, free radicals, stress or other insults which stimulate or stiffen cell membranes. This could lead to one or more forms of joint inflammation. Celadrin® not only halts the cascade of inflammation but rapidly begins restoring flexibility and eliminating pain. Celadrin® accomplishes these features by enhancing the lipid structure of the cell membrane and converting it to a super membrane enabling the cells to rapidly repair and regenerate. This unique enhancement of the cell membrane leads to the multitude of restorative, healing attributes of Celadrin® - including arthritis and inflammatory conditions.

In simple terms, Celadrin® improves the lubrication of joints and prevents the manufacture of compounds that produce pain and inflammation.

1) Can Celadrin® be used with glucosamine sulfate and other natural approaches for osteoarthritis? Absolutely, Celadrin’s® unique mechanisms of action complement any natural or drug therapy for osteoarthritis safely and without side effect.

2) How does Celadrin® compare to CMO (cetylmyristoleate)? CMO is simply one of the components of the unique matrix of Celadrin®. Researchers

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discovered the mixture was more effective than the isolated CMO. Hence, Celadrin® can be simply regarded as an enhanced form of CMO.

3) Is there any difference between the various oral forms of Celadrin®? The product has previously been available in tablets, soft gelatin, and hard gelatin capsules. Since Celadrin® is a fatty acid complex, softgel capsules may provide advantages in absorption, just as with other lipid-loving molecues (e.g. CoQ10). As well, the published clinical trials utilized Celadrin® in a softgel form.

4) Is Celadrin® safe? The safety profile is exceptional with no reported side effects or drug interactions. Celadrin® definitely does not have any of the side effects associated with anti-inflammatory drugs such as Steroids, NSAIDS (e.g. aspirin), and COX 2 inhibitors (e.g. Vioxx, Celebrex).

5) Can Celadrin® be used on a long-term basis? Absolutely, Celadrin® is completely safe for indefinite use without side effect. Are there any interactions with prescription drugs? There is no indication or known mechanism where Celadrin® would cause an adverse interaction with any medication.

What are the joint health benefits in summary:

1. Glucosamine as a major structural component of Chondroitin, stimulates its production.

2. Chondroitin as a major building block of cartilage helps keep it soft and flexible, and protects it from enzymatic destruction.

3. MSM strengthens collagen bonds, creating stronger, healthier cartilage 4. MSM relieves pain and reduces inflammation 5. Celadrin® increases cell membrane integrity helping to reduce pain and

inflammation of damaged joint tissues. 6. Celadrin® helps provide adequate joint lubrication.

Precautions

There are some precautions in taking these ingredients. Chondroitin is chemically similar the blood thinner called heparin. Therefore, it should be used with caution in those who are taking other blood thinners such as aspirin, coumadin, or others. It is important to consult with your physician if you are on other medications, prior to taking this supplement. In addition, there have not been sufficient studies to determine the effect of these ingredients on pregnancy, and are therefore not recommended for pregnant women. If you are allergic to shellfish, you should avoid glucosamine supplements.

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FLX References 1. Hesslink R Jr, Armstrong D 3rd, Nagendran MV, Sreevatsan S, Barathur R. Cetylated fatty acids improve knee function in patients with osteoarthritis. J Rheumatol. 2002;29(8):1708-12.

2. Kraemer WJ, Ratamess NA, Anderson JM, et al. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatol. 2004;31(4):767-74.

3. Kraemer WJ, Ratamess NA, Maresh CM, et al. Effects of treatment with a cetylated fatty acid topical cream on static postural stability and plantar pressure distribution in patients with knee osteoarthritis. J Strength Cond Res. 2005;19(1):115-21.

4. McCarty F. The neglect of glucosamine as a treatment for osteoarthritis. Med Hypotheses 1994;42(5):323-27.

5. Vidal y Plana RR, Karzel K. Glucosamine: Its importance for the metabolism of articular cartilage. Fortschr Med 1980;98(21):801-6.

6. McCarty F. The neglect of gluscosamine as a treatment for osteoarthritis. Med Hypotheses 1994;42(5):323-27.

7. Lopez Vaz A. Double blind clinical evaluation of the relative efficacy of ibupro fen and glucosamine sulfate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8(3):145-49.

8. Noack W, et al. Glucosamnine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2:51-59.

9. Reichelt A, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. Arzneimittelforschung 1994;44(1):75-80 [In German].

10. D'Ambrosio E, et al. Glucosarnine sulphate: A controlled clinical investigation in arthrosis. Pharmatherapeutica 1981;2(8):504-8 [In Italian].

11. Vajaradul Y. Double-blind clinical evaluation of intra-articular glucosamine in outpatients with gonarthritis. Clin Ther 1981;3(5):336-43.

12. Puljate JM, et al. Double blind clinical evaluation of oral glucosamine sulfate in the basic treatement of osteoarthrosis. Curr Med Opin 1980;7(2):110-14.

13. Rovati LC, et al. A large, randomized, placebo-controlled, double-blind study of glucosamnine sulfate vs. piroxicam and vs. their association, on the kinetics of the

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symptomatic effect in knee osteoarthritis. Osteoarthritis Cartilage 1994;2(supplement 1):56.

14. Crolle G, D'Este E. Glucosamine sulphate for the management of arthrosis: A controlled clinical investigation. Curr Med Res Opin 1980;7(2):104-9.

15. Muller-Fassbender H, et al. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2(1):61-69.

16. Dovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulphate in osteoathrosis: A placebo-controlled double blind investigation. Clin Ther 1980;3(4):266-72.

17. Caps JC, et al. Hexosamine metabolism. I. The absorption and metabolism in vivo of orally administered D-glucosamine and N-acetyl-glucosamine in the rat. Biochem Biophys Acta 1966;127:194-204.

18. Kohn P, et al. Metabolism of D-glucosamine and N-acetyl-glucosamine in intact rat. J Biol Chem 1962;237(2):304-8.

19. Tesoriere G, et al. Intestinal abosorption of glucosamine and N-acetyl-glucosamine. Experientia 1972;28:770-771.

20. Qiu G., Gao S., Setnikar I. Efficacy and Safety of Glucosamine Sulfate vs. Ibuprofen in Patients with Knee Osteoarthritis. Osteoarthritis and Cartilage 5:60, 1997

21. Ronca G. Antiinflammatory Activity of Chondrontin Sulfate. Osteoarthritis and Cartilage 5:69, 1997

22. Bourgeois P., Chales G., Dehais J., Delcambre B., Dreyfus P., Kuntz, J., Rosenberg S. Efficacy and Tolerability of Chondroitin Sulfate 1200 MG/DIE vs. Chondroitin Sulfate 3x400 MG/DIE vs. Placebo. Osteoarthritis and Cartilage 5:69, 1997

23. Bucsi L., Poor G. Efficacy and Tolerability of 2x400 MG Oral Chondroitin Sulfate as a Single Dose in the Treatment of Knee Osteoarthritis. Osteoarthritis and Cartilage 5:69, 1997

24. Jimenez S., Dodge G. The Effects of Glucosamine Sulfate (GSO4) on Human Chondrocyte Gene Expression. Osteoarthritis and Cartilage 5:72, 1997

25. Rovati LC. The Clinical Profile of Glucosamine Sulfate as a Selective Symptom Modifying Drug in Osteoarthritis: Current Data and Perspective. Osteoarthritis and Cartilage 5:72, 1997

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26. Reichelt A., Forster K., Fischer M., Rovati L., Setniker I. Efficacy and Safety of Intramuscular Glucosamine Sulfate in Osteoarthritis of the Knee. Arzneimittel-Forschung 44 (1) 75-80, 1994

27. Setnikar I., Giaccheti C., Zanolo G. Pharmacokinetics of Glucosamine in the Dog and Man. Arzneimittel-Forschung 36 (4) 729-735 , 1986

28. Muller-Fassbender H., Bach G., Haase W., Rovati L., Setnikar I. Glucosamine Sulfate Compared to Ibuprofen in Osteoarthritis of the Knee. Osteoarthritis Cartilage (United Kingdom) 2/1 (61-69), 1994

29. Noack W., Fischer M., Forster K., Rovati L., Setnikar I. Glucosamine Sulfate in Osteoarthritis of the Knee. Osteoarthritis Cartilage (United Kingdom) 2/1 (51-59), 1994

30. Jacob SW, Herschler R. Dimethyl sulfoxide after twenty years. Ann N Y Acad Sci. 1983;411:xiii–xvii.

31. Richmond VL. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sci 1986;39:263–8.

32. Rizzo R, Grandolfo M, Godeas C, et al. Calcium, sulfur, and zinc distribution in normal and arthritic articular equine cartilage: a synchrotron radiation-induced X-ray emission (SRIXE) study. J Exp Zool 1995;273:82–6.

33. Murav’ev IuV, Venikova MS, Pleskovskaia GN, et al. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis. Patol Fiziol Eksp Ter 1991;2:37–9 [in Russian].

34. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J of Anti-Aging Med 1998;1:50.

35. Jacob SW, Herschler R. Dimethyl sulfoxide after twenty years. Ann N Y Acad Sci. 1983;411:xiii–xvii.

36. Rose SE, Chalk JB, Galloway GJ, Doddrell DM. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Imaging 2000;18:95–8.

Frequently Asked Questions

Agel Questions 1

Q. Are there any drug interactions related to any of the Agel products?”

A. In general, the Agel products are considered very safe. However, there may be some concern in a few isolated circumstances, particularly with FIT, OHM and FLX. If you are taking prescription medications, we recommend that you consult with your physician prior to using the Agel products.

There are potential concerns for those persons who are taking medications that increase brain serotonin levels. In particular, medications in the category of SSRI’s (Selective Serotonin Re-uptake Inhibitors) are of some concern. In OHM, panax ginseng is one of the active ingredients, and it may cause increased serotonin levels in the brain. In addition, FIT contains Hydroxycitric Acid (HCA) as its primary active ingredient. HCA has been shown to be effective in part by its ability to reduce appetite by increasing brain serotonin levels. In general, for individuals taking medications that increase brain serotonin, there is a theoretical risk of serotonin syndrome.

There are also some precautions in taking FLX. Chondroitin is chemically similar the blood thinner called heparin. Therefore, it should be used with caution in those who are taking other blood thinners such as aspirin, coumadin, or others. In addition, there have not been sufficient studies to determine the effect of these ingredients on pregnancy, and are therefore not recommended for pregnant women. If you are allergic to shellfish, you should avoid glucosamine supplements

Q. Are the Agel Products FDA approved?

A. In the United States, nutritional supplements do not require FDA approval. However, the FDA does regulate the nutritional supplement industry via the Dietary supplement Health Education Act. Agel adheres very strictly to these guidelines and is in compliance with all rules and regulations governing the industry. For further information regarding the FDA guidelines, please refer to the following website: http://www.cfsan.fda.gov/~dms/dietsupp.html

In addition, in every market where Agel is operating, the products are submitted for registration with the appropriate governing board.

Q. Are there artificial colorants used in the formulation of the gels?

A. No. The coloration of each of the gels is a result of the natural color of the ingredients.

Q. Why is the Gel Technology Advantageous?

A. There are three very important factors that influence the efficacy of nutritional supplements: the proper timing of ingestion, compliance (convenience) and the bioavailability of the nutrients. First, the convenience of the portable gel pack facilitates the proper timing for taking the supplements with meals, which enhances the absorption and utilization of each nutrient. Second, the ease of use and the great taste, strongly


Agel Questions 2

enhance compliance with a nutritional program. Third, Gel Technology allows the nutrients to remain suspended in Gel, optimizing bioavailability. Before gel supplements, individuals relied on tablet and capsule forms of nutritional supplements. Unfortunately, typical supplements in a pill form may not always be fully digested and absorbed. However, thanks to gel nutritionals, the digestion of the pills is no longer an issue, and the vitamins and minerals are likely more readily available for absorption.

Q. Where are the nutrients in gel nutritional products absorbed?

A. Each of the ingredients in each of the products contains nutrients that have different and specific methods of absorption along the gastrointestinal tract. For most of these nutrients, the primary location for absorption is in the small intestine. Some of the nutrients are absorbed in ways that are not fully studied in the literature. By suspending nutrients in a gel, all of the nutrients are readily available to be digested and absorbed in the GI tract. By providing a good-tasting, easily ingested, readily available form of these nutrients, we feel that a maximum benefit is obtained.

Q. In the Agel MIN, why is there only 100% of the RDI of vitamins?

A. There is increasing literature to support the concept of moderation in vitamin supplementation. The adage of “too much of a good thing can be harmful” is beginning to become a widely accepted viewpoint among nutritionists and scientists around the world. We feel that the best way to enhance healthy living for the greatest number of people is to create a product that provides 100% of the RDI of vitamins in a single dose. If there are individuals that wish to increase the amount of vitamins in their daily regimen, they may elect to ingest a second MIN gel pack.

Q. Can pregnant women take these products?

A. There are some ingredients in the OHM and the FLX products that have been listed in some texts as not appropriate or not adequately tested for safety during pregnancy. Consequently, we recommend that pregnant woman not consume OHM or FLX.

In addition, it is not recommended that pregnant woman take in more than 5000 IU of vitamin A. There is 5460 IU of vitamin A in the MIN product. Furthermore, MIN is NOT formulated appropriately for complete coverage of the supplemental needs during pregnancy. Do NOT replace MIN for your regular prenatal vitamin. If you are pregnant, prior to taking any vitamins, herbs, supplements or over-the-counter medications, we strongly recommend that you consult with your physician.

Q. Can women take the Agel Gel products while breast-feeding?

A. We recommend that you review the ingredients in these products with your physician prior to using them while breast feeding.


Agel Questions 3

Q. Can children take an entire gel pack?

A. As a point of reference, the American Academy of Pediatrics does not endorse vitamin or nutritional supplementation in children under 16 years old, except for specific groups with chronic illnesses. Furthermore, the mineral needs of children are unclear. Nonetheless, the Agel gel products are generally very safe for all age groups over 3 years old, and small children probably do not need an entire gel pack.

MIN contains 100% of the RDI of the essential vitamins and selected essential minerals for adults. Most children’s vitamins currently on the market contain about the same amount of vitamins as Agel MIN, without the minerals. If you elect to use MIN for your children, the preparation does not contain enough of the vitamins or minerals to be considered dangerous, however, an entire gel pack is probably more than necessary. We recommend consulting with your pediatrician about appropriate dosing of the vitamins and minerals for your children.

Q. Can I take several of the Gel products at one time?

A. As far as we know, there are no problems with consuminng multiple Gel products at one time. Although there is some overlap in the nutrients present in the various Agel products, there is not likely to be enough overlap to be harmful. As a point of reference, MIN contains 100% of the RDI of vitamins and up to 50% of the RDI of minerals for adults. OHM contains a vitamin B-complex that would result in duplication of the B vitamins. If only one of each of the gels was taken at the same time, most of the B vitamins would be less than 150% of the RDI for an adult, and 400% of vitamin B12. EXO contains exotic fruit purees and plant extracts that are high in antioxidants. Because vitamins C and E are both effective anti-oxidant, there would be duplication of the anti-oxidants as well. Prior to taking any vitamins, herbs, supplements or over-the-counter medications, we recommend that you consult with your physician.

Q. Can FIT be taken by children?

A. We recommend consulting with your pediatrician about appropriate food supplementation and weight management regimens for children. As a general rule, we do not recommend diet aids for children, and we therefore do not recommend using FIT in the pediatric population. We advocate healthy eating habits and plenty of physical activity as a means for children to manage weight. To initiate an early habit of dependence on dieting aids in childhood may be sending the wrong message.

Q. How does fructose as the sweetener affect diabetics?

A. Because fructose does not increase blood glucose and does not require insulin, individuals with diabetes can sometimes tolerate it better than other sugars. Fructose is a monosaccharide, or single sugar, that has the same chemical formula as glucose but a different molecular structure. Sometimes called fruit sugar, fructose is found in fruit,


Agel Questions 4

some vegetables, honey, and other plants. Fructose and other sugars are carbohydrates, an important source of energy for the body.

Fructose and other commonly consumed sugars provide basically the same number of calories, but they are metabolized and used by the body in different ways. For instance, glucose from dietary sources is digested, absorbed, transported to the liver, and released into the general blood stream. Many tissues take up glucose from the blood to use for energy; this process requires insulin. Fructose is predominantly metabolized in the liver, but unlike glucose it does not require insulin to be used by the body. This is why fructose has a lower glycemic index and is appropriate for diabetics and others concerned with carbohydrate consumption.

Q. Are Agel’s products “All Natural?”

A. OHM uses synthetic Taurine. Natural Taurine is derived from bile, and to be sensitive to all Agel team members’ varying religious beliefs, we chose to use the synthetic. All of the other ingredients in each of the products are from natural sources.

Q. What is the shelf-life of the Agel products.

A. The shelf-life of the Agel products is 1 year in their sealed packaging. However, all Agel products should be consumed immediately after opening to avoid risk of microbial contamination.

Q. How are Agel’s products sterilized? Does this process damage the nutrients?

A. Because there is always a risk of microbial contamination in any food or food supplement, it is essential that some form of pasteurization be done on the Agel products. Agel has implemented a proprietary low temperature pasteurization that preserves the integrity of the nutrients.

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