Survey Results & analysis for

ATS Assembly on Respiratory Structure & Function Project

Proposal Initiative

Executive SummaryThis report contains a detailed statistical analysis of the results to the survey titled ATS Assembly on Respiratory Structure & Function Project Proposal Initiative . The results analysis includes answers from all respondents who took the survey in the 70 day period from Tuesday, May 12, 2009 to Monday, July 20, 2009. 71 completed responses were received to the survey during this time.

Survey Results & AnalysisSurvey: ATS Assembly on Respiratory Structure & Function Project Proposal Initiative

Author:

Filter:

Responses Received: 71

Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development:

1 2 3

Ventilation/Persusion in artificial ventilation - heterogeneity of perfusion as a cause of hypoventilation: a forgotten issue

Effects of air pollution (physical, chemical, biological) on airway/parenchyma structure and remodeling

 

Exhaled breath analysis for desese diagnosis.

Innovations in technology that may have utlity in the meidical field.

Update on Methacholine challenge testing

Transcriptional mechanisms of recovery from acute lung injury

Altered surfactant metabolism in diseased lung

lung morphogenesis

Respiratory Health Effects of Climate Change

The mechanisms and role of airway nerves in airway diseases.

 

Exhaled breath analysis for disease diagnosis.

Innovations in technology that will have future utility in the medical field.

Update on Methacholine challenge testing

lung repair in COPD    

Severe asthma: pathogenesis and new treatments

Airway Smooth Muscle Cells anf Myofibroblasts as targets for treating asthma and COPD

 

Phenotyping of animal models of emphysema

Quantitative lung imaging Alveolar cell and tissue mechanics

pulmonary vasculopathy in metabolic disease:acute vs chronic inflammatory response

pulmonary vascular response to inflammatory damage: regio-temporal specific "hot spots"

cytoskeletal microdomains in endothelial repair

Functional consequences of airway smooth muscle remodeling

   

Origins of increased smooth muscle in asthma.

Clinical trial of inhaled corticosteroids on airway smooth muscle hyperplasia.

Airway smooth muscle hypertrophy or hyperplasia in COPD.

The significance of the small airways in asthma: measurement, phenotypes & treatment.

   

Complex behavior of the respiratory system in health and disease

   

Cyclical recruitment of atelectasis as a mechanism of ventilator-associated lung injury

   

exhaled breath analysis    

oral-cavity interferences with measurements of exhaled trace constituents from airways

   

Role of extracellular matrix in airway hyperesponsiveness

   

Airway epithelial barrier function in health and disease

Airway epithelial models of health and disease

 

Airway Acid and Oxidative Stress--Biochemical Impacts on Airway Function

   

complex in vitro models: epithelial/endothelial, Epithelial/smooth muscle, Epithelial/leukocyte

   

Interaction of nanoparticles with biological systems and subsequent effects - interaction with the lung, lung tissue and lung cells

Electron tomography - 3D electron microscopy: interaction of nanoparticles with subcellular structures like cytoskeleton, organelles, the nucleus

Nanoparticulate matter in pulmonary medicinal application; diagnistics, therapeutics (nanomedicine)

miRNA in lung function and airway remodeling

   

Dynamics of oxygen delivery Gas equation and it's clinical relation Atelectasis and it's management in context of mechanical ventilation

COPD rehabilitation screening upper mechanics for OSA neuromuscular/chest wall disorders

severe asthma phenotypes animal models for rare pulmonary diseases

therapeutic targets in chronic cough

MODULATION OF SMALL AIRWAY INFLAMMATION IN ASTHMA WITH EXISTING & NEWER INHALERS

INFLUENCE OF VARIOUS BREATHING MANOUVERS ON AIRWAY CALIBRE INCLUDING YOGIC BREATHING WHICH HAS IMMENSE POTENTIAL WHICH HAS NOT BEEN ADDRESSED YET.

VARIABILITY IN ACUTE LUNG INJURY DUE TO DIFFERENT ETIOLOGICAL FACTORS , SEPSIS IN PARTICULAR

Cardiopulmonary exercise capacity in obesity. Typical reporting may mask the fact that many obese are not deconditioned but rather symptomatic. A position document would be very helpful in the area.

Obesity and respiratory function at rest and during exercise. Also, dyspnea on exertion.

 

Tracheostomies in children - standards of care for ongoing management, bronchoscopy etc

   

Dyspnea - more than altered mechanics

   

Obesity Respiratory Muscles  

lung development in the extremely premature neonate, ventilation strategies for these patients

   

In vitro modelling of healthy airways In vitro respiratory drug delivery and testing

 

endothelial dysfuction in ARDS endothelial pathophysiology in pulmonary hypertension

pulmonary circulation in ventilator injury

ATS Methacholine Challange Guideline Update. last was is 1999

Pulmonary Physiology in the 21st century Innovations in testing and design.

Exhaled Breath measurement for Disease. We had previouslt published a paper on detecting Lung cancer. Now we are looking at all disease. This I would like to chair as I have the background and expertise.

Lung residenet stem cells inducible prluripotent stem cells microparticles

Animal models of emphysema Innate immune function in COPD  

Interaction of inflammatory and alveolar epithelial cells in acute lung injury

The role of programmed cellular death in response to stress in resident lung cells

 

stem cell research effect of nanoparticles in health and disease

 

Pulmonary nontuberculous mycobacterial disease

   

x-dr tuberculosis ARDS MULTIRESISTANT ORGANISMS IN VAP

Steroid resistance in structural cells Glucocorticoid signaling Alternative therapy in Severe asthma

New metabolic or lipid pathways that could modulate airway remodeling.

Statins and airway disease.  

Air pollution and lung (dys)function Lung parenchymal structural components: how do they modify function

Better understanting FOT and IOS data

The controversial role of RAGE in lung pathophysiology. Queisser MA et al.,Am J Respir Cell Mol Biol. 2008 Sep;39(3):337-45 Reynolds PR et al.,Am J Respir Cell Mol Biol. 2009 Jun 25 Sternberg DI et al., J Thorac Cardiovasc Surg. 2008 Dec;136(6):1576-85 Englert JM et al., Am J Pathol. 2008 Mar;172(3):583-91 He M et al., Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1427-36.

Mechanisms of alveolar protein clearance in the intact lung Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L679-89. Review

 

The development of airway smooth muscle in utero and early life. Factors influencing cell number.

The composition of the ectracellular matrix in asthma.

 

Role of imaging in lung disease Translation of new technologies to clinical practice

Standards for performance for diagnostic and monitoring tools in critical care

Airway wall remodelling Signal transduction cascades underlying development and severity of airway diseases

Airway hyperresponsiveness; mechanisms and consequences

Airway smooth muscle as a major actor in airway hyperresponsiveness: from whole muscle mechanics to the assesment of crossbridge properties.

Statistical mechanics: a new way to establish a link between microscopic properties of airway smooth muscle and its bulk mechanical properties.

 

Murine and other animal models of COPD

Modeling airway hyperresponsiveness Aging and the lung

1. (Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development:)

1.

Ventilation/Persusion in artificial ventilation - heterogeneity of perfusion as a cause of hypoventilation: a forgotten issue

Exhaled breath analysis for desese diagnosis.

Transcriptional mechanisms of recovery from acute lung injury

Respiratory Health Effects of Climate Change

Exhaled breath analysis for disease diagnosis.

lung repair in COPD

Severe asthma: pathogenesis and new treatments

Phenotyping of animal models of emphysema

pulmonary vasculopathy in metabolic disease:acute vs chronic inflammatory response

Functional consequences of airway smooth muscle remodeling

Origins of increased smooth muscle in asthma.

The significance of the small airways in asthma: measurement, phenotypes & treatment.

Complex behavior of the respiratory system in health and disease

Cyclical recruitment of atelectasis as a mechanism of ventilator-associated lung injury

exhaled breath analysis

oral-cavity interferences with measurements of exhaled trace constituents from airways

Role of extracellular matrix in airway hyperesponsiveness

Airway epithelial barrier function in health and disease

Airway Acid and Oxidative Stress--Biochemical Impacts on Airway Function

complex in vitro models: epithelial/endothelial, Epithelial/smooth muscle, Epithelial/leukocyte

Interaction of nanoparticles with biological systems and subsequent effects - interaction with the lung, lung tissue and lung cells

miRNA in lung function and airway remodeling

Cardiopulmonary exercise capacity in obesity. Typical reporting may mask the fact that many obese are not deconditioned but rather symptomatic. A position document would be very helpful in the area.

Tracheostomies in children - standards of care for ongoing management, bronchoscopy etc

Dyspnea - more than altered mechanics

Obesity

lung development in the extremely premature neonate, ventilation strategies for these patients

In vitro modelling of healthy airways

endothelial dysfuction in ARDS

ATS Methacholine Challange Guideline Update. last was is 1999

Lung residenet stem cells

Animal models of emphysema

Interaction of inflammatory and alveolar epithelial cells in acute lung injury

stem cell research

Pulmonary nontuberculous mycobacterial disease

x-dr tuberculosis

Steroid resistance in structural cells

New metabolic or lipid pathways that could modulate airway remodeling.

Air pollution and lung (dys)function

Dynamics of oxygen delivery

COPD rehabilitation

severe asthma phenotypes

MODULATION OF SMALL AIRWAY INFLAMMATION IN ASTHMA WITH EXISTING & NEWER INHALERS

Airway wall remodelling

Airway smooth muscle as a major actor in airway hyperresponsiveness: from whole muscle mechanics to the assesment of crossbridge properties.

Murine and other animal models of COPD

The controversial role of RAGE in lung pathophysiology. Queisser MA et al.,Am J Respir Cell Mol Biol. 2008 Sep;39(3):337-45 Reynolds PR et al.,Am J Respir Cell Mol Biol. 2009 Jun 25 Sternberg DI et al., J Thorac Cardiovasc Surg. 2008 Dec;136(6):1576-85 Englert JM et al., Am J Pathol. 2008 Mar;172(3):583-91 He M et al., Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1427-36.

The development of airway smooth muscle in utero and early life. Factors influencing cell number.

Role of imaging in lung disease

2.

Effects of air pollution (physical, chemical, biological) on airway/parenchyma structure and remodeling

Innovations in technology that may have utlity in the meidical field.

Altered surfactant metabolism in diseased lung

The mechanisms and role of airway nerves in airway diseases.

Innovations in technology that will have future utility in the medical field.

Airway Smooth Muscle Cells anf Myofibroblasts as targets for treating asthma and COPD

Quantitative lung imaging

pulmonary vascular response to inflammatory damage: regio-temporal specific "hot spots"

Clinical trial of inhaled corticosteroids on airway smooth muscle hyperplasia.

Airway epithelial models of health and disease

Electron tomography - 3D electron microscopy: interaction of nanoparticles with subcellular structures like cytoskeleton, organelles, the nucleus

Gas equation and it's clinical relation

screening upper mechanics for OSA

animal models for rare pulmonary diseases

INFLUENCE OF VARIOUS BREATHING MANOUVERS ON AIRWAY CALIBRE INCLUDING YOGIC BREATHING WHICH HAS IMMENSE POTENTIAL WHICH HAS NOT BEEN ADDRESSED YET.

Obesity and respiratory function at rest and during exercise. Also, dyspnea on exertion.

Respiratory Muscles

In vitro respiratory drug delivery and testing

endothelial pathophysiology in pulmonary hypertension

Pulmonary Physiology in the 21st century Innovations in testing and design.

inducible prluripotent stem cells

Innate immune function in COPD

The role of programmed cellular death in response to stress in resident lung cells

effect of nanoparticles in health and disease

ARDS

Glucocorticoid signaling

Statins and airway disease.

Lung parenchymal structural components: how do they modify function

Mechanisms of alveolar protein clearance in the intact lung Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L679-89. Review

The composition of the ectracellular matrix in asthma.

Translation of new technologies to clinical practice

Signal transduction cascades underlying development and severity of airway diseases

Statistical mechanics: a new way to establish a link between microscopic properties of airway smooth muscle and its bulk mechanical properties. Modeling airway hyperresponsiveness

3. (Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development:)

3.

Update on Methacholine challenge testing

lung morphogenesis

Update on Methacholine challenge testing

Alveolar cell and tissue mechanics

cytoskeletal microdomains in endothelial repair

Airway smooth muscle hypertrophy or hyperplasia in COPD.

Nanoparticulate matter in pulmonary medicinal application; diagnistics, therapeutics (nanomedicine)

Atelectasis and it's management in context of mechanical ventilation

neuromuscular/chest wall disorders

therapeutic targets in chronic cough

VARIABILITY IN ACUTE LUNG INJURY DUE TO DIFFERENT ETIOLOGICAL FACTORS , SEPSIS IN PARTICULAR

pulmonary circulation in ventilator injury

Exhaled Breath measurement for Disease. We had previouslt published a paper on detecting Lung cancer. Now we are looking at all disease. This I would like to chair as I have the background and expertise.

microparticles

MULTIRESISTANT ORGANISMS IN VAP

Alternative therapy in Severe asthma

Better understanting FOT and IOS data

Standards for performance for diagnostic and monitoring tools in critical care

Airway hyperresponsiveness; mechanisms and consequences

Aging and the lung

Acute Lung Injury

Most Desirable Desirable Somewhat Desirable

Not Desirable Least Desirable

Cytoskeletal dynamics in lung health and disease

25.4% (16) 30.2% (19) 28.6% (18) 7.9% (5) 7.9% (5)

Immune response in ventilator-injured lungs

14.3% (9) 38.1% (24) 23.8% (15) 15.9% (10) 7.9% (5)

Advances in ventilator technology and modalities

15.9% (10) 17.5% (11) 42.9% (27) 14.3% (9) 9.5% (6)

Osmotic stress and lung injury & repair

6.3% (4) 28.6% (18) 39.7% (25) 14.3% (9) 11.1% (7)

Cytoskeletal dynamics in lung health and disease(Acute Lung Injury)

Immune response in ventilator-injured lungs(Acute Lung Injury)

Advances in ventilator technology and modalities(Acute Lung Injury)

Osmotic stress and lung injury & repair(Acute Lung Injury)

Lung (Patho)Physiology and Mechanics

Most Desirable Desirable Somewhat Desirable

Not Desirable Least Desirable

Murine models of asthma– strengths, weaknesses, opportunities and threats

16.7% (11) 40.9% (27) 25.8% (17) 9.1% (6) 7.6% (5)

Neural control of the airways

15.4% (10) 29.2% (19) 40.0% (26) 13.8% (9) 1.5% (1)

Modulation of the cough reflex

13.8% (9) 24.6% (16) 36.9% (24) 16.9% (11) 7.7% (5)

TRP channels in airway pathobiology

8.1% (5) 19.4% (12) 43.5% (27) 24.2% (15) 4.8% (3)

Quantifying emphysema in humans and mice

34.8% (23) 19.7% (13) 33.3% (22) 10.6% (7) 1.5% (1)

Neuropeptide modulation airway mechanics in asthma

8.3% (5) 30.0% (18) 43.3% (26) 15.0% (9) 3.3% (2)

Influence of the epithelium on airway calibre

23.4% (15) 46.9% (30) 20.3% (13) 6.3% (4) 3.1% (2)

Small airway function: inflammation, airway calibre and heterogeneity

35.4% (23) 47.7% (31) 12.3% (8) 4.6% (3) 0.0% (0)

Airway hyperresponsiveness: molecules to man

36.9% (24) 35.4% (23) 20.0% (13) 6.2% (4) 1.5% (1)

Role of lung surfactant in modulating airway mechanics in asthma

15.9% (10) 38.1% (24) 30.2% (19) 11.1% (7) 4.8% (3)

Gender differences in health, aging and lung disease

13.4% (9) 34.3% (23) 31.3% (21) 16.4% (11) 4.5% (3)

Vascular barrier properties

8.1% (5) 25.8% (16) 43.5% (27) 14.5% (9) 8.1% (5)

Interstitial matrix molecules and tissue mechanics

18.3% (11) 40.0% (24) 25.0% (15) 10.0% (6) 6.7% (4)

Use of the forced oscillation technique

7.7% (5) 24.6% (16) 32.3% (21) 20.0% (13) 15.4% (10)

Severe asthma – causes, consequences and treatment

41.5% (27) 27.7% (18) 18.5% (12) 9.2% (6) 3.1% (2)

Pathobiology of rare lung diseases

12.3% (8) 18.5% (12) 33.8% (22) 23.1% (15) 12.3% (8)

Aging of the pulmonary system

28.6% (20) 41.4% (29) 18.6% (13) 8.6% (6) 2.9% (2)

Murine models of asthma– strengths, weaknesses, opportunities and threats(Lung (Patho)Physiology and Mechanics)

Neural control of the airways(Lung (Patho)Physiology and Mechanics)

Modulation of the cough reflex(Lung (Patho)Physiology and Mechanics)

TRP channels in airway pathobiology(Lung (Patho)Physiology and Mechanics)

Quantifying emphysema in humans and mice(Lung (Patho)Physiology and Mechanics)

Neuropeptide modulation airway mechanics in asthma(Lung (Patho)Physiology and Mechanics)

Influence of the epithelium on airway calibre(Lung (Patho)Physiology and Mechanics)

Small airway function: inflammation, airway calibre and heterogeneity(Lung (Patho)Physiology and Mechanics)

Airway hyperresponsiveness: molecules to man(Lung (Patho)Physiology and Mechanics)

Role of lung surfactant in modulating airway mechanics in asthma(Lung (Patho)Physiology and Mechanics)

Gender differences in health, aging and lung disease(Lung (Patho)Physiology and Mechanics)

Vascular barrier properties(Lung (Patho)Physiology and Mechanics)

Interstitial matrix molecules and tissue mechanics(Lung (Patho)Physiology and Mechanics)

Use of the forced oscillation technique(Lung (Patho)Physiology and Mechanics)

Severe asthma – causes, consequences and treatment(Lung (Patho)Physiology and Mechanics)

Pathobiology of rare lung diseases(Lung (Patho)Physiology and Mechanics)

Aging of the pulmonary system(Lung (Patho)Physiology and Mechanics)

Airway Smooth Muscle & Airway Remodeling

Most Desirable Desirable Somewhat Desirable

Not Desirable Least Desirable

Developing in vivo methods for measuring airway remodeling

35.9% (23) 35.9% (23) 18.8% (12) 6.3% (4) 3.1% (2)

Epithelial-mesenchymal transition in airway and lung remodeling

22.2% (14) 31.7% (20) 33.3% (21) 11.1% (7) 1.6% (1)

Vascular remodeling in pulmonary hypertension, asthma and COPD

31.7% (20) 28.6% (18) 27.0% (17) 11.1% (7) 1.6% (1)

Airway smooth muscle remodeling and dysfunction in asthma and COPD

31.7% (20) 39.7% (25) 14.3% (9) 12.7% (8) 1.6% (1)

Targeting airway remodeling in asthma treatment

29.7% (19) 37.5% (24) 20.3% (13) 10.9% (7) 1.6% (1)

Apoptosis and fibrotic lung disease

20.6% (13) 31.7% (20) 27.0% (17) 19.0% (12) 1.6% (1)

Association between asthma phenotype and airway remodeling

31.3% (20) 25.0% (16) 29.7% (19) 7.8% (5) 6.3% (4)

Developing in vivo methods for measuring airway remodeling(Airway Smooth Muscle & Airway Remodeling)

Epithelial-mesenchymal transition in airway and lung remodeling(Airway Smooth Muscle & Airway Remodeling)

Vascular remodeling in pulmonary hypertension, asthma and COPD(Airway Smooth Muscle & Airway Remodeling)

Airway smooth muscle remodeling and dysfunction in asthma and COPD(Airway Smooth Muscle & Airway Remodeling)

Targeting airway remodeling in asthma treatment(Airway Smooth Muscle & Airway Remodeling)

Apoptosis and fibrotic lung disease(Airway Smooth Muscle & Airway Remodeling)

Association between asthma phenotype and airway remodeling(Airway Smooth Muscle & Airway Remodeling)

Integrating Structure and Function: Imaging and Modeling

Most Desirable Desirable Somewhat Desirable

Not Desirable Least Desirable

Lung imaging: integrating lung and cell mechanics

33.3% (21) 44.4% (28) 12.7% (8) 4.8% (3) 4.8% (3)

Mathematical modeling of lung disease

11.1% (7) 27.0% (17) 38.1% (24) 15.9% (10) 7.9% (5)

Imaging: novel techniques

20.3% (13) 46.9% (30) 21.9% (14) 7.8% (5) 3.1% (2)

Imaging: early detection of disease

35.9% (23) 28.1% (18) 20.3% (13) 14.1% (9) 1.6% (1)

Imaging: physiological mechanisms in health and disease

38.1% (24) 33.3% (21) 19.0% (12) 7.9% (5) 1.6% (1)

Ventilation heterogeneity: theoretical modeling to imaging

23.4% (15) 23.4% (15) 32.8% (21) 17.2% (11) 3.1% (2)

Nanotechnology in detecting and treating lung disease

25.0% (16) 31.3% (20) 23.4% (15) 14.1% (9) 6.3% (4)

Lung imaging: integrating lung and cell mechanics(Integrating Structure and Function: Imaging and Modeling)

Mathematical modeling of lung disease(Integrating Structure and Function: Imaging and Modeling)

Imaging: novel techniques(Integrating Structure and Function: Imaging and Modeling)

Imaging: early detection of disease(Integrating Structure and Function: Imaging and Modeling)

Imaging: physiological mechanisms in health and disease(Integrating Structure and Function: Imaging and Modeling)

Ventilation heterogeneity: theoretical modeling to imaging(Integrating Structure and Function: Imaging and Modeling)

Nanotechnology in detecting and treating lung disease(Integrating Structure and Function: Imaging and Modeling)

Respiratory and Peripheral Muscle Biology/Physiology

Most Desirable Desirable Somewhat Desirable

Not Desirable Least Desirable

Cell and molecular mechanisms for respiratory and peripheral muscle failure

19.4% (12) 32.3% (20) 33.9% (21) 12.9% (8) 1.6% (1)

Respiratory and peripheral muscle dysfunction in sepsis

18.0% (11) 27.9% (17) 19.7% (12) 24.6% (15) 9.8% (6)

Skeletal muscle weakness in COPD

17.5% (11) 34.9% (22) 27.0% (17) 14.3% (9) 6.3% (4)

Respiratory muscle failure in muscular dystrophy

6.5% (4) 38.7% (24) 22.6% (14) 21.0% (13) 11.3% (7)

Acquired weakness syndromes in critical illness

12.7% (8) 34.9% (22) 25.4% (16) 15.9% (10) 11.1% (7)

Mechanical ventilation induced diaphragm dysfunction

11.3% (7) 32.3% (20) 27.4% (17) 22.6% (14) 6.5% (4)

Mechanisms for exercise endurance in asthma and COPD

23.1% (15) 27.7% (18) 27.7% (18) 13.8% (9) 7.7% (5)

Exercise rehabilitation programs for COPD

21.5% (14) 24.6% (16) 29.2% (19) 13.8% (9) 10.8% (7)

Cell and molecular mechanisms for respiratory and peripheral muscle failure(Respiratory and Peripheral Muscle Biology/Physiology)

Respiratory and peripheral muscle dysfunction in sepsis(Respiratory and Peripheral Muscle Biology/Physiology)

Skeletal muscle weakness in COPD(Respiratory and Peripheral Muscle Biology/Physiology)

Respiratory muscle failure in muscular dystrophy(Respiratory and Peripheral Muscle Biology/Physiology)

Acquired weakness syndromes in critical illness(Respiratory and Peripheral Muscle Biology/Physiology)

Mechanical ventilation induced diaphragm dysfunction(Respiratory and Peripheral Muscle Biology/Physiology)

Mechanisms for exercise endurance in asthma and COPD(Respiratory and Peripheral Muscle Biology/Physiology)

Exercise rehabilitation programs for COPD(Respiratory and Peripheral Muscle Biology/Physiology)

Other:

Most Desirable Desirable Somewhat Desirable

Not Desirable Least Desirable

Hypertonic saline inhalation for cystic fibrosis

11.1% (7) 12.7% (8) 46.0% (29) 23.8% (15) 6.3% (4)

Genetics of COPD 21.9% (14) 34.4% (22) 25.0% (16) 10.9% (7) 7.8% (5)

Hypertonic saline inhalation for cystic fibrosis(Other:)

Genetics of COPD(Other:)