Surface Modification - Blood Compatibility

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    U~pidenaomcffled,olu

    iopnlfdleclh}fn

    `goom!eoard,`cgc}sRfsucedgRpornp}cnuoi@coad}npcdgu0244!0240

    K,^,Gn~ynl

    A,Ue,clAogne~gdpdlmEngg~gdp@corfsuceu

    Du}npcouL}dcuwdu}npcou,l}dcuBhadcg,eoa

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    Cl}pom~e#ol

    Unynpdg`coad}npcdgudpn~unmcl`coanmcedgdrrgced}colucl

    opmnp}oclepndun}fnt~dgc}soigcindlmgcinunvrne}dles,

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    U~pidenaomcJced}coluiopnlfdleclh}fn`goom!eoard}c`cgc}s

    RfsucedgRpornp}cnuoi@coad}npcdgu

    @goomI~le,oldlmRpornp,nu

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    @goomI~le#oldlmRpornp#nu

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    Rgduad PnmEnggu

    Xfc}nEnggu Rgd}ngn}u

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    @goomI~le#oldlmRpornp#nu

    eol}pc`~}nu}o}fncaa~logohcedgusu}na }fnfnaou}d}ceanefdlcuacumnuchlnm}odppnu}`gnnmclhipoaclj~pnm`goomynuungu

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    `n}xnnl:

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    ed~unfdpai~gniine}uiop}fngcyclhophdlcuau

    n,h,iopad}coloi}fpoa`~u

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    @goomI~le#oldlmRpornp#nu

    `goomcudycueo~u'clfoaohnlno~udlmlol!Lnx}olcdlJg~cm

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    adclrpornp}cnu:

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    pnm}cl}&P@Efnaohgo`cl#

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    urnecJcehpdyc}scu4,29hp/ea5

    FE]cumn}npaclnmdu}fn.eol}nl}oi`goomengg~gdpeoarolnl}u

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    U~pidenaomcJced}coluiopnlfdleclh}fn`goom!eoard}c`cgc}s

    RfsucedgRpornp}cnuoi@coad}npcdgu

    @coad}npcdgucl}npde,olxc}f`goomeoarolnl}u

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    @coad}npcdgucl}npde#olxc}f`goomeoarolnl}u

    rpo}ncldmuopr}col rgd}ngn}pnde}colu cl}pcluceeodh~gd}col Jc`pclogs}cede}cyc}snps}fpoes}nu'gn~eoes}nudlmeoargnanl}de}cyd}col

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    fnaou}ducu

    NEArpo}nclu

    3c`pclohnl

    dg`~acl!hgo`~gcl

    eoargnvdlmmsldacerfnloanlddlm}fnnvdacld}col

    oi`!`cl}npde}coluclmced}nu}fd}pngnydl}ind}~pnudpn:

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    Rpo}nclDmuopr#ol

    daclodecmuucmnefdclu&rogdp/lol!rogdp'efdphn#eol}pc`~}n}o}fncl}npde}colu

    }fnrpo}nclaogne~gnudpn}fnJcpu}u~`u}dlenu}fd}dpnd`uop`nm

    }fcurpoenuueol}pc`~}nu}o}fnu~pidende}cyc}s d`co!gdsnpoiF0Odlmrpo}nclucuiopanm engguipoau~ppo~lmclh}cuu~nuachpd}nol}o}fnu~piden

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    Rpo}nclDmuopr#ol

    Ypoadlniine}:rpo}ncluxc}ffchfeolenl}pd}colcl}fn`goom'Jcpu}gsdmuop`nmoldu~piden'`~}m~n}o}fn

    xndkdmfnucolpnrgdenm`so}fnpu

    rpo}nclunvroun}fncpfsmporfo`cepnhcolu}o}fnu~pidenclopmnp}o:

    c, clepndun}fndpndoieol}de}cc, }oaclcaczn}fnnlnphscl}npde}colxc}f}fnu~piden

    Jcldggs'rpo}nclu}nlm}oeoynp}fnxfogndpndoi}fnu~piden

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    AdclIde}opu

    4,}fnrpornp}cnuoirpo}nclaogne~gnu

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    `olmu

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    5,}fnuog~}colefdpde}npcu}ceu

    rFdlmudg}eolenl}pd}col

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    Rpo}nclDmuopr#ol

    }fnadclcl}npde}coludpn:fsmpohnl`olmclh!YdlmnpXddgungne}pou}d}ce

    }fnpaomsldaceycnxrocl}::H1F!]U

    }fnrpoenuua~u}`nu~iJcecnl}gsnvo}fnpaceop}o`ndeeoardlcnm`sdgdphnclepndunoinl}pors

    72 H72 U

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    Dmynpunnflne}u

    fnaogsucu:mnu}p~e}coloinps}fpoes}nu;carnmnu}fnecpe~gd}opsusu}nad`cgc}s}o}pdluinpO0}o}fn

    }cuu~nu

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    efdlhnuclego}}clhide}opudlmxfc}n`goomenggde}cyd}col

    CUO425!=:0222:Ungne}coloi}nu}uiopcl}npde}coluxc}f`goom

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    U~pidenaomcJced}coluiopnlfdleclh}fn`goom!eoard}c`cgc}s

    RfsucedgRpornp}cnuoi@coad}npcdgu

    U~pidenRpornp,nudlmAomcffled,olU}pd}nhcnu

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    U~pidenRpornp#nudlmAomcffled#olU}pd}nhcnu

    u~pidenrpornp}cnudpnducarop}dl}du}fn`~gkrpornp}cnudlmoi}nlmnJclnndefo}fnp

    u~pidenefdpde}npcu}ceudpnpnuroluc`gniop}fneol}pogoicl}npde}colu`n}xnnl}fnad}npcdgdlm}fnnv}npldgnlycpolanl}

    `cogohcedgpnurolunu}o`coad}npcdgudpnpngd}nmxc}f}fnu~pidenefnacu}psdlmu}p~e}~pn'}orohpdrfsdlmnlnphs

    clopmnp}oclepndun}fn`goom!eoard}c`cgc}s'u~piden

    aomcJced}colu}neflct~nudpnlnenuudpsdlmufo~gmpn}dcl}fn

    rfsuceoefnacedgrpornp}cnu}oclJg~nlen`co!cl}npde}colu

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    U~pidenRpornp#nudlmAomcffled#olU}pd}nhcnu

    u~pidenaomc3ced}col}neflct~nudpn}psclh}oor}caczn:

    rpo}ncldmuopr}col'hnlnpd}coloi}fpoa`cldlmc}ui~le}col

    &`goomeodh~gd}colrgd}ngn}dmfnucolengg~gdp`nfdycopcl}fnu~piden#

    adclaomc3ced}colu}pd}nhcnu:c, efnacedgoprfsucedgdg}npld}colu}od}oaudlm/op

    aogne~gnucl}fnnvcu}clhu~piden

    cc, eod}clhoynp}fnnvcu}clhu~pidenxc}fdad}npcdg'xfcef

    fdyndlnxeoarouc}col

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    U~pidenaomcJced}coluiopnlfdleclh}fn`goom!eoard}c`cgc}s

    RfsucedgRpornp}cnuoi@coad}npcdgu

    Aomcffled,olAn}fomu

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    Fsmpohngu

    dpnfsmporfcgcerogsanpceu}p~e}~pnu eol}dcleoydgnl}dlmfsmpohnl`olmu rfsucedgepouu!gclku hoynplnm`sYdlmnpXddgucl}npde}colu `clmcl}fncpyog~angdphndao~l}oiF0O mnhpnnoiJgnvc`cgc}sucacgdp}of~adl}cuu~nu goxcl}npidecdg}nlucol clepndunfsmporfcgcec}s mol}u~rrop}enggdmfnucoldlm}fpoa`~uiopad}col

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    Ungi!Duuna`gnmAologdsnp&UDAu

    ophdlcznmophdlceJcgau darfcrfcgceaogne~gnuefnacuopr}coloidefnacedgu~`u}dlenclduogcmu~`u}pd}n

    mpcyclhiopen}oJcgg}fnu~piden

    aogne~gdpgnyngeol}pogdlmndusiopad}col efdlhnu}o}fn}dcghpo~rumol}diine}}fnpnu}aogne~gn efdlhndfsmporfo`ceu~piden}ofsmporfcgce

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    U~pidenAomcisclhDmmc#ynu&UAD

    uadggaogne~gdpxnchf}dlmgoxeolenl}pd}coleoardpnm}o`~gkrpornp}cnu

    }fncl}npidecdgnlnphsmciinpnlengndm}fndmmc}cynu}oeolenl}pd}ncl}fnu~piden

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    pndef}fno~}npu~piden UAD`gnlmnmrogsanpuopUADeod}nmu~pidenu'clepndun}fn`goomeoard}c`cgc}sdlmmnepndun}fnpcuk

    oi}fpoa`ohnlcec}s

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    Gdlha~cp@gomhnHMnrouc#ol

    Darfcrfcgceaogne~gnudpnurpndmolF0Odlmeoarpnuunm`sd`dppcnp}oeoaroundaologdsnpoiophdlcead}npcdg,]fnl}fns}pdluinppnm}odynp}cedgrgd}nd}eolu}dl}u~pidenrpnuu~pn,Icldggs'fchfgsopmnpnmdlmde}cynaogne~gnueoynp

    du~piden,

    G@Jcgaeol}dcluolnopaopnaologdsnpu cuiopanm`saogne~gnuxc}ffsmporfo`ce}dcgudlmfsmporfcgcefndmu

    }fnfndm!xd}npcl}npde}colucuaopnidyopd`gn}fdl}fndcp!xd}np

    pnm~e}coloi}fnu~pidennlnphsfchfmnhpnnoiopmnp&rfsucedgdmfnucol#

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    Fnrdpcl!acan#ead}npcdgu

    fnrdpclcudldl}ceodh~gdl}dlmaclcaczn}fpoa`~uiopad}cololdp}cJcecdgu~pidenu

    aomcJcnmusl}fn}cerogsanpuxc}fucacgdprpornp}cnuxc}ffnrdpcl

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    eoargced}colu

    caao`cgcznefnacedggsdl}ceodh~gdl}}oclepndun`goomeoard}c`cgc}soidrogsanp

    hpdi}clhu~grfold}ndlm/opdaclodecmu~grfoldacmnhpo~ruolcluog~`gnrogsu}spnln

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    Rgduad]pnd}anl}u

    rgduadcu}fn=}fu}d}noiad}}np ucacgdpc}cnuxc}fcolcznmhdu eolucu}uoi:n!'colu'rfo}olu'ipnnpdmcedgudlmln~}pdgrdp}cegnu

    cuepnd}nm`s}fndrrgced}coloinlnphs:PI'acepoxdynu'gdunpop

    n!ipoadfo}Jcgdanl}}odhduuo~pencldyde~~aefda`np

    `nfdynueoggne}cyngslournecJceufdrndlmyog~an

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    Rgduad]pnd}anl}u

    xfnldld}oaopdaogne~gnhdclunlo~hfnlnphs'colczd}coloee~pu

    clucmn}fnrgduad:

    rdp}cegnuao}col1goedgdee~a~gd}coluw&+#op&!# gdphnuedgnng,Jcngmudiine}}fnao}coloiefdphnmrdp}cegnuidpnlo~hfeoardpnm}o}fncpuczn

    ngdu}cedlmclngdu}ceeoggcucolu aoanl}~adlmefdphn}pdluinp

    ed~unrdp}cegnue~ppnl}}fd}d`~}}o}fnu~piden

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    Rgduad]pnd}anl}u

    pnaoynud}oauopefna,hpo~ruipoa}fnu~piden`s`olmJcuucolu

    hduno~u'an}dggce'dlmgdunp!`dunmuo~penu Jgoxoiipnnpdmcedgudlmcoluipoargduad}o}fn`coad}npcdg

    colczd}col'ipdhanl}d}coldlmnvec}d}col}pnd}anl}udpnpngcd`gn'gox!eou}dlmdrrgced`gn}omciinpnl}hnoan}pcnu

    ed~unefdlhnuclefnacedg'ngne}pcedg'`cogohcedg'or}cedg'dlmanefdlcedgrpornp}cnu

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    Rgduadur~Hnpclhdlmn}efclh

    u~pidenegndlclh}neflct~nuycdefnacedgpnde}colu clnp}hdunuu~efdulnoldlmdpholdpn~unm 4}ounynpdgkYdpndrrgcnmdlmdpholrgduadcuhnlnpd}nm

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    d`chrop}coloi}fncpnlnphscu}pdluinppnm}o}fnu~pidend}oauycdngdu}cedlmclngdu}ceeoggcucolu

    uoanu~pidend}oaunuedrncl}o}fnyde~~aefda`np

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    Rgduadur~Hnpclhdlmn}efclh

    }fn~lmnpgsclhgdsnpuxcgg`nnvrounmdlmn}efnm di}npnlo~hfur~}}npclh}can'u~pidenxcgg`negndlnmoii

    }xorouuc`gndlmeoarn}c}cynpnde}colu:

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    cl}npde}coludlmrgduadrogsanpczd}col

    0, mnhpdmd}col:n}efclhxcgg}dknrgdencl}fnu~piden

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    Rgduadur~Hnpclhdlmn}efclh

    Rgduadn}efclh:

    di}npnlo~hf}canoinvrou~pn}orgduad'}fnnvrounmgdsnpuoi}fnrogsanpudpnn}efnmoii

    }fnpd}noixnchf}gouucumnrnlmnl}ol}fnld}~pnoirogsanpdlm}fnnlnphsoirgduad

    fdrrnluadclgscl}fn}orgdsnp }fnaomcJcnmrogsanpufdyn}fnudanrfsuceoefnacedgrpornp}cnudu}fnopchcldgolnu

    [eoarouc}col'u}p~e}~pn'mnhpnnoirogsanpczd}colQ

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    Rgduadcargdl}d#oloirogsanpu

    rogsanpcead}npcdgudpnfsmporfo`ce }fneolynpucol}ofsmporfcgcecarpoynudmfnucolu}pnlh}fdlm`coeoard}c`cgc}s

    drogsanpnvrounm}orgduad'epouu!gclknmefdcluedl`niopanm

    fsmpohnlcud`u}pde}nmipoarogsanpefdclu}oepnd}npdmcedgu

    pdmcedgupneoa`clnxc}fucargnpdmcedguepnd}nm`shdu}oiopaovshnli~le}coldgc}cnu

    colcargdl}d}coldlm}fniopad}coloiovshnli~le}coldgc}cnuclepndun}fnfsmporfcgcerpornp}cnu

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    Rgduadmnrouc#ol

    }fclrgduadcurpom~enmm~n}o}fnde}coloirgduadnducgsrpnrdpnm

    rclfogn!ipnn'mnlun'epouu!gclknm de}dudlniJcecnl}`dppcnp xfnleolu}c}~nl}uoirgduaddpnde}cyd}nm'rogsanpczn`sdmmc}colpnde}col

    dee~a~gd}coloidrogsanpceeod}clhxc}feol}poggnm}fceklnuu

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    Eoleg~ucolu

    `goom!`coad}npcdgudpndlnv}pnangseoargnvrfnloanlolm~n}o}fnl~a`npoirdpdan}npu,

    }fnrfsucogohcedgpnurolunoi`goomdlmc}uanefdlcuaudpnxnggmnJclnmxfnld

    `coad}npcdgnl}np}fn}fnf~adl`oms

    unynpdg}neflct~nuipoaAd}npcdguUecnlencleoa`cld}colxc}f`cogohs!opcnl}nman}fomu}ps

    }oclepndun}fngnynguoi`goom!eoard}c`cgc}s

    clmcycm~dg~udhnrnpedun