Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1...

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Subbannayya et al , 2015. Identification of differentially expressed serum proteins in gastric adenocarcinoma Supplementary Table 3. Peptides identified in serum of gastric adenocarcinoma patients using Sequest and Mascot search algorithms Peptide sequence Gene symbol Protein Description Entrez GeneID Refseq Accession # PSMs # Proteins Protein Group (GI) Accessions Modifications Tumor/Normal Fold- change (116+117)/(114+115) (116+117)/ (114+115) Count (116+117)/(1 14+115) Variability [%] 115/114 Ratio 115/114 Count 115/114 Variability [%] 116/114 Ratio 116/114 Count 116/114 Variability [%] 116/115 Ratio 116/115 Count 116/115 Variability [%] 117/114 Ratio 117/114 Count 117/114 Variability [%] 117/115 Ratio 117/115 Count 117/115 Variability [%] 117/116 Ratio 117/116 Count 117/116 Variability [%] IonScore Xcorr # Missed Cleavages Charge m/z (Da) Delta Mass (ppm) RT (min) Precusor mass (MH+ [Da]) AAAATGTIFTFR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens] 5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR POSTN periostin isoform 4 precursor [Homo sapiens] 10631 NP_001129408 2 4 209863034 N-Term(iTRAQ4plex) 1.257 1 1.067 1 1.18 1 1.106 1 1.417 1 1.329 1 1.201 1 80 8.86 0 3 769.75836 1.16 47.66 2307.26053 AAANQMR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens] 721;720 NP_001002029 NP_000583 XP_001722858;NP _009224 XP 003403837 27 6 178557739;67 190748 N-Term(iTRAQ4plex) 1.397 1 0.791 1 1.092 1 1.38 1 1.411 1 1.783 1 1.292 1 4.56 0 3 778.76355 2.75 35.89 2334.2761 AAAPNTPK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens] 10216 NP_001121181 2 4 189181722 N-Term(iTRAQ4plex); K8(iTRAQ4plex) 1.031 1 0.683 1 0.792 1 1.159 1 0.943 1 1.38 1 1.19 1 58 3.63 0 2 736.92059 -0.23 37.02 1472.83391 AAAVSEAEADFYEQNSR NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens] 4669 NP_000254 2 1 66346698 N-Term(iTRAQ4plex) 1.223 1 0.915 1 1.162 1 1.271 1 1.18 1 1.29 1 1.015 1 38 4.59 0 3 759.41443 -3.53 21.01 2276.22873 AACAQLNDFLQEYGTQGC QV C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens] 721;720 NP_001002029 NP_000583 XP_001722858;NP _009224 XP 003403837 63 6 178557739;67 190748 N-Term(iTRAQ4plex); C3(Methylthio); C18(Methylthio) 1.375 1 0.992 1 1.273 1 1.284 1 1.465 1 1.477 1 1.151 1 32 0 2 966.97949 -2.88 43.96 1932.95171 AACLPLPGYR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 1 1 167614506 N-Term(iTRAQ4plex); C3(Methylthio) 1.473 1 0.979 1 1.247 1 1.274 1 1.668 1 1.704 1 1.337 1 5 0 3 829.73639 -0.62 66.55 2487.19461 AADDTWEPFASGK TTR transthyretin precursor [Homo sapiens] 7276 NP_000362 12 1 4507725 N-Term(iTRAQ4plex); K13(iTRAQ4plex) 1.693 2 2.8 0.762 2 1.9 1.349 2 4 1.77 2 2.1 1.634 2 3.3 2.143 2 1.4 1.211 2 0.7 83 5.65 0 3 874.82733 -2.37 43.04 2622.46177 AAECPAGFVRPPLIIFSVDG FR ENPP2 ectonucleotide pyrophosphatase/phosphodiesteras e family member 2 isoform 2 preproprotein [Homo sapiens] 5168 NP_001035181 4 3 91823602 N-Term(iTRAQ4plex); C4(Methylthio) 0.916 1 0.788 1 0.823 1 1.046 1 0.814 1 1.034 1 0.989 1 74 8.57 0 3 985.76453 0.74 49.25 2955.27903 AAFCYQIR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens] 4485 NP_066278 1 1 205277383 N-Term(iTRAQ4plex); C4(Methylthio) 1.35 2 16.5 0.892 2 2.2 1.212 2 21.5 1.359 2 23.8 1.341 2 10.1 1.502 2 12.3 1.106 2 11.3 72 4.56 0 2 811.44531 0.88 66.81 1621.88335 AAGDTTVIENSDVSPETESS EK KTN1 kinectin isoform c [Homo sapiens] 3895 NP_004977 2 3 118498368 N-Term(iTRAQ4plex); K22(iTRAQ4plex) 1.457 5 10.8 1.007 5 5.9 1.288 5 10.9 1.386 5 3.5 1.635 5 13.2 1.624 5 2 1.166 5 5.2 60 5.21 0 2 791.44788 0.35 45.42 1581.88848 AAGNECPELQPPVHGK MASP1;MAS P1;MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan- binding lectin serine protease 1 isoform 3 precursor [Homo sapiens] 5648;5648; 5648 NP_001027019;NP _001027019;NP_00 1027019 2 3 21264359;736 23026;212643 57 N-Term(iTRAQ4plex); C6(Methylthio); K16(iTRAQ4plex) 1.416 2 18.8 0.982 2 4 1.243 2 10 1.265 2 14.1 1.562 2 22.2 1.59 2 26.4 1.257 2 12 41 8.36 0 4 785.76666 2.38 38.21 2355.27651 AAGVPSATITWR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens] 3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex) 1.121 1 1.029 1 1.061 1 1.031 1 1.214 1 1.18 1 1.144 1 35 3.56 0 2 756.85931 1.57 38.67 1512.71135 AAIQALR APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex) 1.499 1 0.842 1 1.283 1 1.524 1 1.478 1 1.756 1 1.152 1 6.58 0 4 620.3031 -2.93 28.62 2478.19057 AAISGENAGLVR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens] 3697 NP_002206 45 1 156119625 N-Term(iTRAQ4plex) 1.684 54 32.8 0.992 54 18.7 1.472 54 28.7 1.503 54 30.7 1.788 54 32.2 1.847 54 31.7 1.153 54 13.7 146 7.66 0 3 1271.6908 2.58 46.03 2542.36759 AALTELSLGSAYQAMILGVD SK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 107 1 105990532 N-Term(iTRAQ4plex); M15(Oxidation); K22(iTRAQ4plex) 1.26 12 7.1 0.875 12 8.3 1.12 12 9.6 1.243 12 13 1.33 12 6.2 1.446 12 14.8 1.148 12 4 134 6.38 0 3 1088.5731 -0.95 41.21 2176.13944 AALTELSLGSAYQAMILGVD SK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 25 1 105990532 N-Term(iTRAQ4plex); K22(iTRAQ4plex) 1.341 57 10.4 1.003 57 13.8 1.242 57 13.3 1.257 57 11.2 1.396 57 11.7 1.425 57 9.4 1.116 57 7.5 133 9.14 0 3 1171.1771 4.24 59.42 2341.34697 AAMVGMLANFLGFR AGT angiotensinogen preproprotein [Homo sapiens] 183 NP_000020 69 1 4557287 N-Term(iTRAQ4plex) 0.907 13 28.9 0.945 13 27.2 0.95 13 25.3 0.776 13 31.7 1 13 51.6 0.914 13 29.3 1.173 13 23.5 125 7.09 0 4 1271.6908 2.58 46.03 2526.37407 AAMVGMLANFLGFR AGT angiotensinogen preproprotein [Homo sapiens] 183 NP_000020 50 1 4557287 N-Term(iTRAQ4plex); M3(Oxidation) 1.826 17 15.6 1.017 17 21.2 1.737 17 13.5 1.664 17 18.9 1.904 17 18.1 1.881 17 24.1 1.154 17 8.3 125 9.08 0 3 1386.2501 4 59.44 2771.49297 AAMVGMLANFLGFR AGT angiotensinogen preproprotein [Homo sapiens] 183 NP_000020 3 1 4557287 N-Term(iTRAQ4plex); M3(Oxidation); M6(Oxidation) 1.327 11 7.9 0.882 11 13.3 1.191 11 17.2 1.373 11 7.2 1.383 11 20.3 1.48 11 5.9 1.112 11 8.7 123 7.76 0 3 1177.6194 3.56 81.15 2354.23716 AANSLEAFIFETQDK HYOU1 hypoxia up-regulated protein 1 precursor [Homo sapiens] 10525 NP_006380 4 1 5453832 N-Term(iTRAQ4plex); K15(iTRAQ4plex) 1.366 47 14.6 0.963 47 16.6 1.251 47 18.9 1.329 47 19.4 1.377 47 18.4 1.464 47 11.1 1.107 47 8.2 122 7.39 0 3 1126.1379 3.33 51.57 2251.26487 AAPEASGTPSSDAVSR CORO1A coronin-1A [Homo sapiens] 11151 NP_009005 2 1 5902134 N-Term(iTRAQ4plex) 1.355 89 13.4 1.013 89 12.3 1.255 89 16.1 1.267 89 12.8 1.419 89 19.2 1.428 89 13.8 1.133 89 10.7 122 7.7 0 2 1018.0487 -2.48 51.63 2035.09429 AAPGQEPPEHMAELQR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens] 5768 NP_002817 NP_689875 6 1 13325075 N-Term(iTRAQ4plex) 1.38 44 13.6 0.965 44 9.9 1.282 44 16.2 1.3 44 13.8 1.42 44 13.9 1.469 44 15.4 1.134 44 8.4 121 7.8 0 3 1221.6718 -0.36 77.85 2442.33623 AAPGQEPPEHMAELQR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens] 5768 NP_002817 NP_689875 2 1 13325075 N-Term(iTRAQ4plex); M11(Oxidation) 1.308 46 9.5 0.932 46 11.5 1.176 46 9.2 1.295 46 13.7 1.355 46 10.1 1.467 46 12.5 1.133 46 7.2 120 7.46 0 3 1208.6364 -1.8 39.3 2416.26651 AAQEEYVK ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens] 226 NP_000025 1 3 4557305 N-Term(iTRAQ4plex); K8(iTRAQ4plex) 1.433 37 23.9 0.79 36 23.9 1.23 37 29.6 1.458 36 30.4 1.363 37 29.4 1.663 36 34 1.167 36 28 119 11.77 0 3 1145.2219 1.76 61.33 3433.65525 AAQFEPPGR FCGR2A low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor [Homo sapiens] 2212 NP_067674 XP_943942 2 3 50511936 N-Term(iTRAQ4plex) 1.299 28 7.7 0.894 28 7.1 1.158 28 7 1.262 28 8.4 1.32 28 11.1 1.459 28 11.9 1.146 28 4.8 118 6.77 0 2 915.04504 5.08 26.28 1829.07671 AAQVTIQSSGTFSSK A2M alpha-2-macroglobulin precursor [Homo sapiens] 2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); K15(iTRAQ4plex) 1.654 38 11.6 0.952 38 18 1.57 38 21.6 1.593 38 11.7 1.669 38 13.3 1.779 38 10.1 1.113 38 7.9 117 6.39 0 2 1090.5823 -0.19 73.77 2180.15727 AASEEVSRRR MOCS1 molybdenum cofactor biosynthesis protein 1 isoform 4 [Homo sapiens] 4337 NP_001068566 1 1 116734668 N-Term(iTRAQ4plex) 1.31 11 12.6 0.979 11 7.7 1.322 11 13.1 1.336 11 8.3 1.299 11 12.3 1.369 11 19.5 1.073 11 11.9 115 7.11 0 3 1149.5078 -8.51 25.58 2298.00835 AASGTQNNVLR C7 complement component C7 precursor [Homo sapiens] 730 NP_000578 13 1 45580688 N-Term(iTRAQ4plex) 1.544 1 1.559 1 1.751 1 1.123 1 2.201 1 1.412 1 1.258 1 112 7.46 0 3 1385.067 -1.04 80.71 4153.1865 AASGTTGTYQEWK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex) 0.549 4 24.4 0.979 4 1.6 0.521 4 22.1 0.532 4 25.1 0.564 4 16.6 0.577 4 18.3 1.193 4 3.1 112 6.71 0 3 1126.1379 3.33 51.57 2235.27207 AATGECTATVGK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens] 3827;3827 NP_000884;NP_00 0884 94 3 4504893;1562 31037 N-Term(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex) 1.463 16 20.5 0.912 16 23.3 1.316 16 25.3 1.327 16 11 1.62 16 30.2 1.461 16 18.2 1.142 16 13.7 109 5.77 0 2 1227.0748 -1.46 26.1 2453.14238 AATGECTATVGKR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens] 3827;3827 NP_000884;NP_00 0884 2 3 4504893;1562 31037 N-Term(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex) 1.219 2 4.9 1.072 2 26.2 1.193 2 19.7 1.112 2 6.3 1.343 2 17.2 1.253 2 8.7 1.126 2 2.4 109 5.46 0 2 844.43689 8 16.74 1687.83183 AATVGSLAGQPLQER APOE apolipoprotein E precursor [Homo sapiens] 348 NP_000032 12 1 4557325 N-Term(iTRAQ4plex) 1.355 45 10.8 0.971 45 24 1.208 45 20.1 1.265 45 24.9 1.344 45 14.6 1.496 45 19.2 1.138 45 14.3 109 8.91 0 3 1393.6882 -1.14 37.74 2786.36806 AAVYQPQPHPQPPPYGHC VTDSGVVYSVGMQWLK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens] 2335;2335 NP_997639;NP_99 7639 8 6 47132549;169 33542 N-Term(iTRAQ4plex); C18(Methylthio); K34(iTRAQ4plex) 1.347 21 7 0.895 21 3.1 1.189 21 6.3 1.325 21 8.8 1.366 21 5.9 1.52 21 8.3 1.117 21 4.2 108 6.01 0 2 935.52075 1.57 28.86 1870.03179 AAVYQPQPHPQPPPYGHC VTDSGVVYSVGMQWLK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens] 2335;2335 NP_997639;NP_99 7639 1 6 47132549;169 33542 N-Term(iTRAQ4plex); C18(Methylthio); M30(Oxidation); K34(iTRAQ4plex) 1.292 23 12.2 0.994 23 19.8 1.199 23 21.5 1.23 23 15.1 1.425 23 19.8 1.329 23 15.7 1.128 23 7.8 107 6.96 0 2 973.54187 -1.69 52.29 1946.07646 ACDGINDCGDQSDELCCK CFI complement factor I preproprotein [Homo sapiens] 3426 NP_000195 18 1 119392081 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); C16(Methylthio); C17(Methylthio); K18(iTRAQ4plex) 1.262 12 7.2 0.943 12 5 1.175 12 5.3 1.249 12 4.7 1.264 12 7.9 1.367 12 8.5 1.129 12 8.4 107 6.33 0 2 1009.5865 5 70.43 2018.1657 ACEPGVDYVYK C3 complement C3 precursor [Homo sapiens] 718 NP_000055 29 1 115298678 N-Term(iTRAQ4plex); C2(Methylthio); K11(iTRAQ4plex) 1.296 60 11.5 0.984 60 9.7 1.208 60 11.3 1.232 60 12 1.347 60 15.5 1.372 60 15.4 1.103 60 5.9 106 6.83 0 2 837.99658 -1.3 56.26 1674.98345 ACGACPLWGK C7 complement component C7 precursor [Homo sapiens] 730 NP_000578 15 1 45580688 N-Term(iTRAQ4plex); C2(Methylthio); C5(Methylthio); K10(iTRAQ4plex) 1.365 18 11.1 0.867 18 14.4 1.168 18 12.7 1.397 18 14.1 1.328 18 10.6 1.541 18 19.6 1.143 18 13.1 106 8.12 0 3 990.84637 0.49 63.62 2970.52457 ACIPTGPYPCGK F10 coagulation factor X preproprotein [Homo sapiens] 2159 NP_000495 16 1 4503625 N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio); K12(iTRAQ4plex) 1.339 12 19.9 0.966 12 12 1.235 12 32.3 1.174 12 21 1.456 12 35.3 1.429 12 24.2 1.214 12 13.2 106 7.49 0 3 1362.7002 1.75 60.21 2724.39311 ACPSHQPDISSGLELPFPPG VPTLDNIK ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens] 1893 NP_004416 13 2 221316614 N-Term(iTRAQ4plex); C2(Methylthio); K28(iTRAQ4plex) 1.463 19 9.1 1.022 19 10.6 1.375 19 11.4 1.353 19 7.3 1.598 19 14 1.555 19 8.7 1.14 19 5.6 105 5.84 0 2 923.99969 -4.32 39.98 1846.99211 ADDKVYPGEQYTYMLLATE EQSPGEGDGNCVTR CP ceruloplasmin precursor [Homo sapiens] 1356 NP_000087 6 1 4557485 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C30(Methylthio) 1.244 11 23.1 0.974 11 12 1.169 11 14.9 1.229 11 38.7 1.364 11 13.3 1.354 11 15.7 1.102 11 11.6 104 9.09 0 3 881.8363 6.07 81.14 2643.48081 ADEVTLSEAGSTAGAAETR GAVEGAAR PALM paralemmin-1 isoform 2 [Homo sapiens] 5064 NP_001035224 1 2 93141029 N-Term(iTRAQ4plex) 0.872 3 18.6 1.105 3 10.1 0.551 3 2.7 0.568 3 30.2 1.255 3 11.2 1.136 3 1.1 1.524 3 52.2 103 5.67 0 2 1090.6331 4.88 80.71 2180.25884 ADGNQLTLEER CD109 CD109 antigen isoform 3 precursor [Homo sapiens] 135228 NP_001153060 2 3 227430303 N-Term(iTRAQ4plex) 1.281 9 8 0.796 9 7.3 1.176 9 13.8 1.432 9 12.1 1.162 9 23.4 1.415 9 18.9 1.042 9 24.6 102 7.66 0 4 1232.6683 -4.25 20.83 2464.34463 ADGSGSVVLR LRP1 prolow-density lipoprotein receptor- related protein 1 precursor [Homo sapiens] 4035 NP_002323 2 1 126012562 N-Term(iTRAQ4plex) 1.229 20 22.6 0.973 20 18.7 1.257 20 35.1 1.206 20 16.6 1.291 20 26.2 1.402 20 20.2 1.125 20 8.6 102 5.49 0 3 945.53137 -1.1 33.13 1890.05828 ADGSYAAWLSR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens] 721;720 NP_001002029 NP_000583 XP_001722858;NP _009224 XP 003403837 25 6 178557739;67 190748 N-Term(iTRAQ4plex) 1.493 10 21.2 0.865 10 26.1 1.361 10 26.8 1.48 10 16.7 1.518 10 23.2 1.735 10 25.3 1.102 10 16.6 102 8.38 0 3 881.11816 -3.44 80.98 2641.35019 ADIEK ZC3H7B zinc finger CCCH domain- containing protein 7B [Homo sapiens] 23264 NP_060060 NP_079289 4 1 27881484 N-Term(iTRAQ4plex); K5(iTRAQ4plex) 1.887 15 14.9 0.973 15 24 1.874 15 15 1.673 15 8.5 2.054 15 19 1.894 15 13.7 1.115 15 8.8 101 5.85 0 2 872.03125 2.61 81.2 1743.05522 ADIGCTPGSGK C3 complement C3 precursor [Homo sapiens] 718 NP_000055 4 1 115298678 N-Term(iTRAQ4plex); C5(Methylthio); K11(iTRAQ4plex) 1.326 22 13.3 1.033 22 10 1.296 22 16.7 1.161 22 18.1 1.445 21 14.2 1.344 22 13.2 1.133 22 7.4 101 6.4 0 2 897.49341 -2.91 20.5 1793.97222 ADLEMQIESLKEELAYLK KRT14 keratin, type I cytoskeletal 14 [Homo sapiens] 3861 NP_000517 4 1 15431310 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K18(iTRAQ4plex) 0.401 4 30.8 0.992 4 26.1 0.503 4 36.7 0.579 4 59.5 0.486 3 59.7 0.465 3 40.7 1.008 3 3.2 99 9.11 0 3 1454.1587 -0.5 27.44 2907.30667 ADLEMQIESLTEELAYLK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens] 3858 NP_000412 XP_352920 29 2 195972866 N-Term(iTRAQ4plex); K18(iTRAQ4plex) 1.295 12 17.3 0.982 12 10.2 1.283 12 14.9 1.261 12 10.2 1.342 12 19.8 1.348 12 15.2 1.085 12 7.6 99 6.69 0 3 1068.5331 -5.17 34.7 2136.05889 ADLEMQIESLTEELAYLK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens] 3858 NP_000412 XP_352920 10 2 195972866 N-Term(iTRAQ4plex); M5(Oxidation); K18(iTRAQ4plex) 1.427 15 46.4 0.915 14 20.7 1.289 13 32.5 1.457 14 23.5 1.403 14 41 1.428 15 22.7 1.11 14 22.1 99 8.29 0 3 1454.1587 -0.5 27.44 2923.30766 ADLFYDVEALDLESPK HRG histidine-rich glycoprotein precursor [Homo sapiens] 3273 NP_000403 101 1 4504489 N-Term(iTRAQ4plex); K16(iTRAQ4plex) 1.57 5 3.9 0.847 5 7.6 1.413 5 4.5 1.697 5 10.1 1.443 5 16.2 1.705 5 8.9 1.013 5 3.2 98 6.67 0 3 1086.0272 -9.69 23.53 2171.05277 ADLSGITGAR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens] 12 NP_001076 84 1 50659080 N-Term(iTRAQ4plex) 1.424 13 8 0.994 13 12.8 1.392 13 18.5 1.355 13 10.4 1.476 13 9.4 1.513 13 9.6 1.126 13 7.6 98 6.51 0 3 1109.0546 -2.18 47.15 2217.10185 ADNFLLENTLPAQSTFTLAIS AYALSLGDK C5 complement C5 preproprotein [Homo sapiens] 727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K30(iTRAQ4plex) 1.367 27 11.5 0.991 27 10.1 1.256 27 17.5 1.273 27 13.2 1.429 27 13.4 1.509 27 19.3 1.128 27 5.8 97 5.96 0 2 989.54083 -1.16 50.36 1978.08049 ADQVCINLR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens] 2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C5(Methylthio) 1.312 9 10.4 1.017 9 22.3 1.344 9 6.5 1.328 9 5 1.337 9 19.8 1.431 9 29.7 1.003 9 33.3 97 8.07 0 3 1072.8694 -0.13 51.92 3216.58774 ADSEGSNSGGTWPK DLG5 disks large homolog 5 [Homo sapiens] 9231 NP_004738 3 1 95089461 N-Term(iTRAQ4plex); K14(iTRAQ4plex) 1.011 5 6.7 0.963 5 18.2 0.809 5 19.5 0.854 5 2.9 1.08 5 19.8 1.245 5 11.4 1.343 5 18.3 96 7.91 0 4 1217.6587 0.98 81.47 2434.30898 ADSPMDDFFQCVNGK CFI complement factor I preproprotein [Homo sapiens] 3426 NP_000195 4 1 119392081 N-Term(iTRAQ4plex); M5(Oxidation); C11(Methylthio); K15(iTRAQ4plex) 1.236 8 12.6 1.068 8 29.8 1.157 8 27.1 1.103 8 17.1 1.303 8 37.4 1.302 8 18.7 1.14 8 7.6 96 7.4 0 3 995.54248 1.41 22.59 1990.07773 ADSPMDDFFQCVNGK CFI complement factor I preproprotein [Homo sapiens] 3426 NP_000195 34 1 119392081 N-Term(iTRAQ4plex); C11(Methylthio); K15(iTRAQ4plex) 1.345 18 11.9 0.938 18 14.5 1.22 18 13.4 1.33 18 10.9 1.341 18 18.9 1.541 18 7.7 1.117 18 8.5 95 4.99 0 3 863.45142 -0.41 43.5 1725.89792 ADSQAQLLLSTVVGVFTAP GLHLK AGT angiotensinogen preproprotein [Homo sapiens] 183 NP_000020 170 1 4557287 N-Term(iTRAQ4plex); K24(iTRAQ4plex) 1.293 79 15.3 0.947 79 25.4 1.217 79 28.8 1.277 79 21.3 1.362 79 24.2 1.395 79 26.3 1.141 79 23.3 95 8.48 0 3 924.12646 1.97 71.67 2770.36063 ADSVVDLLSYNVQGSGETT YDHK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 87 1 105990532 N-Term(iTRAQ4plex); K23(iTRAQ4plex) 1.436 37 9.5 0.999 37 19.1 1.346 37 18.7 1.346 37 4.4 1.503 37 14.8 1.503 37 7.6 1.116 37 6.5 94 5.44 0 2 971.49664 3.26 35.63 1941.98601 ADTLTDEINFLR KRT6A keratin, type II cytoskeletal 6A [Homo sapiens] 3853 NP_005545 NP_490596 2 3 5031839 N-Term(iTRAQ4plex) 1.184 14 10.8 0.91 14 12.8 1.068 14 21.1 1.102 14 18.2 1.219 14 10.6 1.306 14 10.5 1.125 14 13.3 94 9.27 0 3 946.47601 1.71 42.14 2837.41349 ADTVAK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex) 1.25 9 10.7 0.879 9 17.2 1.086 9 9.1 1.319 9 17.6 1.218 9 24.4 1.433 9 19.6 1.139 9 11.4 94 9.13 0 3 1360.6823 -4.9 26.83 2720.35526 ADVQAHGEGQEFSITCLVD EEEMK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens] 3697 NP_002206 154 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); K24(iTRAQ4plex) 1.261 15 8.2 0.926 15 13.3 1.084 15 14.3 1.195 15 10.7 1.328 15 10.8 1.401 15 7.7 1.162 15 7.7 94 6.83 0 3 1070.023 0.46 47.91 2139.03667 ADVQAHGEGQEFSITCLVD EEEMK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens] 3697 NP_002206 4 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); M23(Oxidation); K24(iTRAQ4plex) 1.366 18 10.8 0.927 18 16.5 1.231 18 26.1 1.331 18 30 1.375 18 14.4 1.481 18 20.6 1.157 18 13.9 93 7.95 0 3 1409.2208 1.61 45.78 2817.42752 ADVQAHGEGQEFSITCLVD EEEMKK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens] 3697 NP_002206 17 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); K24(iTRAQ4plex); K25(iTRAQ4plex) 1.431 21 13.6 1.024 21 20.3 1.447 21 16 1.396 21 8.6 1.556 21 17.9 1.494 21 10.7 1.114 21 9.9 93 6.18 0 3 1044.0535 -0.73 32.45 2087.10063 ADVQAHGEGQEFSITCLVD EEEMKK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens] 3697 NP_002206 2 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); M23(Oxidation); K24(iTRAQ4plex); K25(iTRAQ4plex) 1.38 11 15.5 1.088 11 22.5 1.299 11 18.3 1.219 11 13.8 1.48 11 15.2 1.449 11 17.6 1.207 11 5.3 93 6.36 0 3 1089.0759 -4.75 43.94 2177.15311 ADYVETVLDSTCSSTVQFLE YELNVLGTHK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); C12(Methylthio); K30(iTRAQ4plex) 1.62 5 4.8 0.972 5 3.4 1.437 5 4.3 1.558 5 37.2 1.748 5 7.9 1.769 5 6 1.182 5 13.8 93 6.02 0 3 1089.0759 -4.75 43.94 2193.14261 AEAQAQYSAAVAK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens] 3700;3700 NP_002209;NP_00 2209 156 2 31542984;262 050538 N-Term(iTRAQ4plex); K13(iTRAQ4plex) 1.368 8 19.5 1.179 8 10.3 1.546 8 26.2 1.214 8 27.9 1.608 8 14.1 1.407 8 22.5 1.066 8 24.1 92 7.43 0 4 1327.7037 -1.01 65.51 2654.39028 AEATTLHVAPQGTAMAVST FR C8G complement component C8 gamma chain precursor [Homo sapiens] 733 NP_000597 28 1 166197660 N-Term(iTRAQ4plex) 1.22 8 10.7 1.111 8 23.7 1.207 8 13.3 1.017 8 5.6 1.347 8 12.2 1.24 8 6.2 1.135 8 3.2 92 6.05 0 2 934.98608 3 25.16 1868.9572 AEATTLHVAPQGTAMAVST FR C8G complement component C8 gamma chain precursor [Homo sapiens] 733 NP_000597 8 1 166197660 N-Term(iTRAQ4plex); M15(Oxidation) 1.101 2 3.6 0.853 2 19.2 0.97 2 14.5 1.137 2 4.6 1.073 2 10.6 1.258 2 8.5 1.107 2 3.8 92 3.79 0 2 890.90314 -9.48 21.26 1780.799 AECMLQQAER LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 1 167614506 N-Term(iTRAQ4plex); C3(Methylthio) 1.342 26 12.7 0.964 26 11 1.227 26 14.9 1.285 26 9.1 1.409 26 14.2 1.474 26 13.9 1.14 26 6.3 92 6.2 0 2 844.50769 -0.22 57.92 1688.00078 AEDHFSVIDFNQNIR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens] 3698 NP_002207 86 1 70778918 N-Term(iTRAQ4plex) 1.146 7 12 1.011 7 12.2 1.082 7 22.2 1.14 7 9.6 1.238 7 10.2 1.294 7 10.3 1.167 7 5.7 90 4.75 0 2 780.44745 -0.47 25.78 1559.88762 AEDLVGK C3 complement C3 precursor [Homo sapiens] 718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex) 1.358 3 3.1 0.927 3 2.7 1.231 3 0 1.329 3 2.7 1.408 3 3.3 1.492 3 3.7 1.143 3 3.3 90 5.08 0 2 763.92645 -7.43 19.52 1526.84563 AEEEHLGILGPQLHADVGD K CP ceruloplasmin precursor [Homo sapiens] 1356 NP_000087 20 1 4557485 N-Term(iTRAQ4plex); K20(iTRAQ4plex) 1.272 10 22.1 0.98 10 13.3 1.189 10 38.5 1.239 10 18 1.338 10 25.1 1.484 10 8.7 1.117 10 6.5 90 5.64 0 2 799.45532 -0.38 28.05 1597.89653 AEEHTVVLTVTGEPCHFPF QYHR F12 coagulation factor XII precursor [Homo sapiens] 2161 NP_000496 5 1 145275213 N-Term(iTRAQ4plex); C15(Methylthio) 1.112 18 16.6 0.932 18 25.5 1.087 18 27.9 1.109 18 18.2 1.145 18 23.7 1.204 18 20 1.095 18 13.9 90 5.04 0 3 890.90314 -9.48 21.26 1796.81157 AEELLSR INPP5D phosphatidylinositol-3,4,5- trisphosphate 5-phosphatase 1 isoform b [Homo sapiens] 3635 NP_005532 XP_935053 1 2 40254823 N-Term(iTRAQ4plex) 1.179 109 8 0.878 109 12.5 1.03 109 10.4 1.145 109 13 1.208 109 9.3 1.319 109 11.5 1.161 109 9.4 89 7.37 0 4 544.97046 1.8 23.64 1632.89865 AEFQDALEK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens] 721;720 NP_001002029 NP_000583 XP_001722858;NP _009224 XP 003403837 233 6 178557739;67 190748 N-Term(iTRAQ4plex); K9(iTRAQ4plex) 1.219 4 5.5 0.821 4 9.2 0.998 4 7.3 1.244 4 5.8 1.162 4 13.1 1.456 4 4.9 1.141 4 2.8 89 4.42 0 2 776.42145 -3.45 23.24 1551.83733 AEFQDALEKLNMGITDLQG LR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens] 721;720 NP_001002029 NP_000583 XP_001722858;NP _009224 XP 003403837 2 6 178557739;67 190748 N-Term(iTRAQ4plex); K9(iTRAQ4plex) 1.422 15 6.5 0.979 15 16.6 1.398 15 11.5 1.44 15 13.8 1.47 15 11.7 1.501 15 10.9 1.055 15 8.1 89 8.38 0 3 787.76044 0.62 65.93 2361.26676 AEIEYLEK SELL L-selectin precursor [Homo sapiens] 6402 NP_000646 4 1 262206315 N-Term(iTRAQ4plex); K8(iTRAQ4plex) 1.429 7 7.8 0.933 7 15.3 1.277 7 18.4 1.346 7 6 1.454 7 11.2 1.534 7 6.9 1.14 7 4.7 88 5.9 0 2 787.96814 -4.21 24.26 1574.92986 AELLVTEAPSKPITVTVEEQ R HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens] 3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex); K11(iTRAQ4plex) 1.517 14 11.4 1.038 14 15.4 1.437 14 17.3 1.407 14 8.3 1.577 14 16 1.561 14 9.8 1.104 14 5.4 88 5.96 0 3 1019.9926 -3.36 39.54 2038.97795 AELQEGAR APOA1 apolipoprotein A-I preproprotein [Homo sapiens] 335 NP_000030 2 1 4557321 N-Term(iTRAQ4plex) 1.31 26 15.6 0.961 26 22.9 1.157 26 21.2 1.227 26 18.4 1.365 26 21 1.448 26 16.9 1.132 26 11.7 87 4.85 0 3 997.54059 2.71 68.13 1994.06797 AEMADQAAAWLTR C4B complement C4-B preproprotein [Homo sapiens] 721 NP_001002029 NP_000583 XP_001722858 77 4 178557739 N-Term(iTRAQ4plex) 1.523 10 3 1.145 10 18.6 1.443 10 18.5 1.332 10 8 1.658 10 14.9 1.482 10 12.7 1.129 10 3.7 87 5.19 0 2 824.96216 3.75 19.2 1648.90849 AEMADQAAAWLTR C4B complement C4-B preproprotein [Homo sapiens] 721 NP_001002029 NP_000583 XP_001722858 24 4 178557739 N-Term(iTRAQ4plex); M3(Oxidation) 1.489 20 18 1.006 20 18.7 1.493 20 25.9 1.417 20 17.5 1.486 20 25.5 1.544 20 14.6 1.139 20 6.7 87 5.39 0 2 859.99927 -1.1 34.71 1718.98284 AEMADQASAWLTR C4A complement C4-A isoform 1 preproprotein [Homo sapiens] 720 NP_009224 XP_003403837 31 2 67190748 N-Term(iTRAQ4plex) 1.356 45 12.5 0.957 45 17.8 1.211 45 20.8 1.297 45 10.8 1.402 45 24.2 1.481 45 10.7 1.15 45 11.1 86 7.13 0 3 779.42316 2.56 74.16 2336.24576 AEMADQASAWLTR C4A complement C4-A isoform 1 preproprotein [Homo sapiens] 720 NP_009224 XP_003403837 2 2 67190748 N-Term(iTRAQ4plex); M3(Oxidation) 1.499 4 6.2 1.074 4 10.5 1.441 4 11.2 1.372 4 7.9 1.688 4 8.8 1.552 4 2 1.087 4 5.9 85 7.73 0 3 1127.1544 7.1 36.27 2253.29276 AEPLAFTFSHDYK APOB apolipoprotein B-100 precursor [Homo sapiens] 338 NP_000375 12 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex) 1.289 2 13.1 1.079 2 11 1.21 2 21.4 1.121 2 32.9 1.462 2 4.1 1.355 2 6.9 1.208 2 25.7 85 8.98 1 4 1014.5505 3.29 48.02 3041.62612 AEPPKAPEQEQAAPGPAAG GEAPK BASP1 brain acid soluble protein 1 [Homo sapiens] 10409 NP_006308 1 1 30795231 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K24(iTRAQ4plex) 1.304 25 10.9 1.007 25 15.1 1.209 25 20.6 1.247 25 8 1.37 25 15 1.362 25 10 1.087 25 5.9 85 5.43 0 2 765.92273 -1.6 27.44 1530.84026 AEQCCEETASSISLHGK C9 complement component C9 precursor [Homo sapiens] 735 NP_001728 14 1 4502511 N-Term(iTRAQ4plex); C4(Methylthio); C5(Methylthio); K17(iTRAQ4plex) 1.209 10 12.4 0.884 10 3.7 1.068 10 13.7 1.291 10 22 1.142 10 9.1 1.333 10 15 1.084 10 13.3 84 5.86 0 3 922.51343 0.45 69.86 1844.01798 AESPEVCFNEESPK AFM afamin precursor [Homo sapiens] 173 NP_001124 42 1 4501987 N-Term(iTRAQ4plex); C7(Methylthio); K14(iTRAQ4plex) 1.291 18 8.2 0.938 18 10.1 1.208 18 7.7 1.265 18 7.3 1.366 18 13.5 1.426 18 10.7 1.145 18 5.7 84 7.44 0 3 1129.1157 0.97 43.85 2257.22124 AETECQNTEYQQLLDIK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens] 3858 NP_000412 XP_352920 12 2 195972866 N-Term(iTRAQ4plex); C5(Methylthio); K17(iTRAQ4plex) 1.262 5 17.1 0.907 5 21.1 1.081 5 26.5 1.247 5 8.3 1.31 5 36.9 1.443 5 12.1 1.129 5 11.1 83 5.4 0 3 737.90881 -0.04 12.24 1474.81363 AETGDK CP ceruloplasmin precursor [Homo sapiens] 1356 NP_000087 2 1 4557485 N-Term(iTRAQ4plex); K6(iTRAQ4plex) 1.311 6 8.9 1.025 6 7 1.254 6 0.8 1.205 6 4.3 1.436 6 10 1.384 6 14.3 1.148 6 8.9 83 7.02 0 3 907.46246 -10.31 24.3 1813.91874 AETGDTVLK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens] 7412 NP_001069 2 3 4507875 N-Term(iTRAQ4plex); K9(iTRAQ4plex) 1.431 19 6.2 1.021 19 6.6 1.365 19 8.8 1.319 19 6.5 1.499 19 9.9 1.519 19 6.4 1.13 19 4.5 83 6.27 0 2 960.49524 -0.67 46.37 1919.9832 AEVDDVIQVR F5 coagulation factor V precursor [Homo sapiens] 2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 1.353 44 14 0.998 44 14.5 1.275 44 19.4 1.237 44 11.7 1.472 44 15.6 1.438 44 12.7 1.141 44 5.5 83 5.49 0 2 798.94641 -1.3 53.32 1596.88555 AFALWSAVTPLTFTR MMP9 matrix metalloproteinase-9 preproprotein [Homo sapiens] 4318 NP_004985 1 1 74272287 N-Term(iTRAQ4plex) 1.39 41 11.2 0.97 41 8.2 1.303 41 22.3 1.352 41 17.5 1.448 41 15.7 1.479 41 13 1.158 41 11.8 83 6.7 0 3 1090.6331 4.88 80.71 2196.24369

Transcript of Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1...

Page 1: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

Subbannayya et al , 2015. Identification of differentially expressed serum proteins in gastric adenocarcinoma

Supplementary Table 3. Peptides identified in serum of gastric adenocarcinoma patients using Sequest and Mascot search algorithms

Peptide sequenceGene

symbolProtein Description

Entrez GeneID

Refseq Accession # PSMs # ProteinsProtein

Group (GI) Accessions

ModificationsTumor/Normal Fold-

change (116+117)/(114+115)

(116+117)/(114+115)

Count

(116+117)/(114+115)

Variability [%]

115/114 Ratio

115/114 Count

115/114 Variability

[%]

116/114 Ratio

116/114 Count

116/114 Variability

[%]

116/115 Ratio

116/115 Count

116/115 Variability

[%]

117/114 Ratio

117/114 Count

117/114 Variability

[%]

117/115 Ratio

117/115 Count

117/115 Variability

[%]

117/116 Ratio

117/116 Count

117/116 Variability

[%]IonScore Xcorr

# Missed Cleavages

Charge m/z (Da)Delta Mass (ppm)

RT (min)Precusor mass

(MH+ [Da])

AAAATGTIFTFR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329

AAAITSDILEALGR POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 2 4 209863034 N-Term(iTRAQ4plex) 1.257 1 1.067 1 1.18 1 1.106 1 1.417 1 1.329 1 1.201 1 80 8.86 0 3 769.75836 1.16 47.66 2307.26053

AAANQMR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

27 6 178557739;67190748

N-Term(iTRAQ4plex) 1.397 1 0.791 1 1.092 1 1.38 1 1.411 1 1.783 1 1.292 1 4.56 0 3 778.76355 2.75 35.89 2334.2761

AAAPNTPK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 2 4 189181722 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.031 1 0.683 1 0.792 1 1.159 1 0.943 1 1.38 1 1.19 1 58 3.63 0 2 736.92059 -0.23 37.02 1472.83391

AAAVSEAEADFYEQNSR NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 2 1 66346698 N-Term(iTRAQ4plex) 1.223 1 0.915 1 1.162 1 1.271 1 1.18 1 1.29 1 1.015 1 38 4.59 0 3 759.41443 -3.53 21.01 2276.22873

AACAQLNDFLQEYGTQGCQV

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

63 6 178557739;67190748

N-Term(iTRAQ4plex); C3(Methylthio); C18(Methylthio)

1.375 1 0.992 1 1.273 1 1.284 1 1.465 1 1.477 1 1.151 1 32 0 2 966.97949 -2.88 43.96 1932.95171

AACLPLPGYR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 1 1 167614506 N-Term(iTRAQ4plex); C3(Methylthio)

1.473 1 0.979 1 1.247 1 1.274 1 1.668 1 1.704 1 1.337 1 5 0 3 829.73639 -0.62 66.55 2487.19461

AADDTWEPFASGK TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 12 1 4507725 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.693 2 2.8 0.762 2 1.9 1.349 2 4 1.77 2 2.1 1.634 2 3.3 2.143 2 1.4 1.211 2 0.7 83 5.65 0 3 874.82733 -2.37 43.04 2622.46177

AAECPAGFVRPPLIIFSVDGFR

ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 4 3 91823602 N-Term(iTRAQ4plex); C4(Methylthio)

0.916 1 0.788 1 0.823 1 1.046 1 0.814 1 1.034 1 0.989 1 74 8.57 0 3 985.76453 0.74 49.25 2955.27903

AAFCYQIR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 1 1 205277383 N-Term(iTRAQ4plex); C4(Methylthio)

1.35 2 16.5 0.892 2 2.2 1.212 2 21.5 1.359 2 23.8 1.341 2 10.1 1.502 2 12.3 1.106 2 11.3 72 4.56 0 2 811.44531 0.88 66.81 1621.88335

AAGDTTVIENSDVSPETESSEK

KTN1 kinectin isoform c [Homo sapiens] 3895 NP_004977 2 3 118498368 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.457 5 10.8 1.007 5 5.9 1.288 5 10.9 1.386 5 3.5 1.635 5 13.2 1.624 5 2 1.166 5 5.2 60 5.21 0 2 791.44788 0.35 45.42 1581.88848

AAGNECPELQPPVHGK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

2 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C6(Methylthio); K16(iTRAQ4plex)

1.416 2 18.8 0.982 2 4 1.243 2 10 1.265 2 14.1 1.562 2 22.2 1.59 2 26.4 1.257 2 12 41 8.36 0 4 785.76666 2.38 38.21 2355.27651

AAGVPSATITWR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex) 1.121 1 1.029 1 1.061 1 1.031 1 1.214 1 1.18 1 1.144 1 35 3.56 0 2 756.85931 1.57 38.67 1512.71135

AAIQALR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex) 1.499 1 0.842 1 1.283 1 1.524 1 1.478 1 1.756 1 1.152 1 6.58 0 4 620.3031 -2.93 28.62 2478.19057

AAISGENAGLVR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 45 1 156119625 N-Term(iTRAQ4plex) 1.684 54 32.8 0.992 54 18.7 1.472 54 28.7 1.503 54 30.7 1.788 54 32.2 1.847 54 31.7 1.153 54 13.7 146 7.66 0 3 1271.6908 2.58 46.03 2542.36759

AALTELSLGSAYQAMILGVDSK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 107 1 105990532 N-Term(iTRAQ4plex); M15(Oxidation); K22(iTRAQ4plex)

1.26 12 7.1 0.875 12 8.3 1.12 12 9.6 1.243 12 13 1.33 12 6.2 1.446 12 14.8 1.148 12 4 134 6.38 0 3 1088.5731 -0.95 41.21 2176.13944

AALTELSLGSAYQAMILGVDSK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 25 1 105990532 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.341 57 10.4 1.003 57 13.8 1.242 57 13.3 1.257 57 11.2 1.396 57 11.7 1.425 57 9.4 1.116 57 7.5 133 9.14 0 3 1171.1771 4.24 59.42 2341.34697

AAMVGMLANFLGFR AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 69 1 4557287 N-Term(iTRAQ4plex) 0.907 13 28.9 0.945 13 27.2 0.95 13 25.3 0.776 13 31.7 1 13 51.6 0.914 13 29.3 1.173 13 23.5 125 7.09 0 4 1271.6908 2.58 46.03 2526.37407

AAMVGMLANFLGFR AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 50 1 4557287 N-Term(iTRAQ4plex); M3(Oxidation)

1.826 17 15.6 1.017 17 21.2 1.737 17 13.5 1.664 17 18.9 1.904 17 18.1 1.881 17 24.1 1.154 17 8.3 125 9.08 0 3 1386.2501 4 59.44 2771.49297

AAMVGMLANFLGFR AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 3 1 4557287 N-Term(iTRAQ4plex); M3(Oxidation); M6(Oxidation)

1.327 11 7.9 0.882 11 13.3 1.191 11 17.2 1.373 11 7.2 1.383 11 20.3 1.48 11 5.9 1.112 11 8.7 123 7.76 0 3 1177.6194 3.56 81.15 2354.23716

AANSLEAFIFETQDK HYOU1 hypoxia up-regulated protein 1 precursor [Homo sapiens]

10525 NP_006380 4 1 5453832 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.366 47 14.6 0.963 47 16.6 1.251 47 18.9 1.329 47 19.4 1.377 47 18.4 1.464 47 11.1 1.107 47 8.2 122 7.39 0 3 1126.1379 3.33 51.57 2251.26487

AAPEASGTPSSDAVSR CORO1A coronin-1A [Homo sapiens] 11151 NP_009005 2 1 5902134 N-Term(iTRAQ4plex) 1.355 89 13.4 1.013 89 12.3 1.255 89 16.1 1.267 89 12.8 1.419 89 19.2 1.428 89 13.8 1.133 89 10.7 122 7.7 0 2 1018.0487 -2.48 51.63 2035.09429AAPGQEPPEHMAELQR QSOX1 sulfhydryl oxidase 1 isoform a

precursor [Homo sapiens]5768 NP_002817

NP_6898756 1 13325075 N-Term(iTRAQ4plex) 1.38 44 13.6 0.965 44 9.9 1.282 44 16.2 1.3 44 13.8 1.42 44 13.9 1.469 44 15.4 1.134 44 8.4 121 7.8 0 3 1221.6718 -0.36 77.85 2442.33623

AAPGQEPPEHMAELQR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 1 13325075 N-Term(iTRAQ4plex); M11(Oxidation)

1.308 46 9.5 0.932 46 11.5 1.176 46 9.2 1.295 46 13.7 1.355 46 10.1 1.467 46 12.5 1.133 46 7.2 120 7.46 0 3 1208.6364 -1.8 39.3 2416.26651

AAQEEYVK ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens]

226 NP_000025 1 3 4557305 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.433 37 23.9 0.79 36 23.9 1.23 37 29.6 1.458 36 30.4 1.363 37 29.4 1.663 36 34 1.167 36 28 119 11.77 0 3 1145.2219 1.76 61.33 3433.65525

AAQFEPPGR FCGR2A low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor [Homo sapiens]

2212 NP_067674 XP_943942

2 3 50511936 N-Term(iTRAQ4plex) 1.299 28 7.7 0.894 28 7.1 1.158 28 7 1.262 28 8.4 1.32 28 11.1 1.459 28 11.9 1.146 28 4.8 118 6.77 0 2 915.04504 5.08 26.28 1829.07671

AAQVTIQSSGTFSSK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.654 38 11.6 0.952 38 18 1.57 38 21.6 1.593 38 11.7 1.669 38 13.3 1.779 38 10.1 1.113 38 7.9 117 6.39 0 2 1090.5823 -0.19 73.77 2180.15727

AASEEVSRRR MOCS1 molybdenum cofactor biosynthesis protein 1 isoform 4 [Homo sapiens]

4337 NP_001068566 1 1 116734668 N-Term(iTRAQ4plex) 1.31 11 12.6 0.979 11 7.7 1.322 11 13.1 1.336 11 8.3 1.299 11 12.3 1.369 11 19.5 1.073 11 11.9 115 7.11 0 3 1149.5078 -8.51 25.58 2298.00835

AASGTQNNVLR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 13 1 45580688 N-Term(iTRAQ4plex) 1.544 1 1.559 1 1.751 1 1.123 1 2.201 1 1.412 1 1.258 1 112 7.46 0 3 1385.067 -1.04 80.71 4153.1865

AASGTTGTYQEWK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.549 4 24.4 0.979 4 1.6 0.521 4 22.1 0.532 4 25.1 0.564 4 16.6 0.577 4 18.3 1.193 4 3.1 112 6.71 0 3 1126.1379 3.33 51.57 2235.27207

AATGECTATVGK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

94 3 4504893;156231037

N-Term(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex)

1.463 16 20.5 0.912 16 23.3 1.316 16 25.3 1.327 16 11 1.62 16 30.2 1.461 16 18.2 1.142 16 13.7 109 5.77 0 2 1227.0748 -1.46 26.1 2453.14238

AATGECTATVGKR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

2 3 4504893;156231037

N-Term(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex)

1.219 2 4.9 1.072 2 26.2 1.193 2 19.7 1.112 2 6.3 1.343 2 17.2 1.253 2 8.7 1.126 2 2.4 109 5.46 0 2 844.43689 8 16.74 1687.83183

AATVGSLAGQPLQER APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 12 1 4557325 N-Term(iTRAQ4plex) 1.355 45 10.8 0.971 45 24 1.208 45 20.1 1.265 45 24.9 1.344 45 14.6 1.496 45 19.2 1.138 45 14.3 109 8.91 0 3 1393.6882 -1.14 37.74 2786.36806

AAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

8 6 47132549;16933542

N-Term(iTRAQ4plex); C18(Methylthio); K34(iTRAQ4plex)

1.347 21 7 0.895 21 3.1 1.189 21 6.3 1.325 21 8.8 1.366 21 5.9 1.52 21 8.3 1.117 21 4.2 108 6.01 0 2 935.52075 1.57 28.86 1870.03179

AAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

1 6 47132549;16933542

N-Term(iTRAQ4plex); C18(Methylthio); M30(Oxidation); K34(iTRAQ4plex)

1.292 23 12.2 0.994 23 19.8 1.199 23 21.5 1.23 23 15.1 1.425 23 19.8 1.329 23 15.7 1.128 23 7.8 107 6.96 0 2 973.54187 -1.69 52.29 1946.07646

ACDGINDCGDQSDELCCK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 18 1 119392081 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); C16(Methylthio); C17(Methylthio); K18(iTRAQ4plex)

1.262 12 7.2 0.943 12 5 1.175 12 5.3 1.249 12 4.7 1.264 12 7.9 1.367 12 8.5 1.129 12 8.4 107 6.33 0 2 1009.5865 5 70.43 2018.1657

ACEPGVDYVYK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 29 1 115298678 N-Term(iTRAQ4plex); C2(Methylthio); K11(iTRAQ4plex)

1.296 60 11.5 0.984 60 9.7 1.208 60 11.3 1.232 60 12 1.347 60 15.5 1.372 60 15.4 1.103 60 5.9 106 6.83 0 2 837.99658 -1.3 56.26 1674.98345

ACGACPLWGK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 15 1 45580688 N-Term(iTRAQ4plex); C2(Methylthio); C5(Methylthio); K10(iTRAQ4plex)

1.365 18 11.1 0.867 18 14.4 1.168 18 12.7 1.397 18 14.1 1.328 18 10.6 1.541 18 19.6 1.143 18 13.1 106 8.12 0 3 990.84637 0.49 63.62 2970.52457

ACIPTGPYPCGK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 16 1 4503625 N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio); K12(iTRAQ4plex)

1.339 12 19.9 0.966 12 12 1.235 12 32.3 1.174 12 21 1.456 12 35.3 1.429 12 24.2 1.214 12 13.2 106 7.49 0 3 1362.7002 1.75 60.21 2724.39311

ACPSHQPDISSGLELPFPPGVPTLDNIK

ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 13 2 221316614 N-Term(iTRAQ4plex); C2(Methylthio); K28(iTRAQ4plex)

1.463 19 9.1 1.022 19 10.6 1.375 19 11.4 1.353 19 7.3 1.598 19 14 1.555 19 8.7 1.14 19 5.6 105 5.84 0 2 923.99969 -4.32 39.98 1846.99211

ADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 6 1 4557485 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C30(Methylthio)

1.244 11 23.1 0.974 11 12 1.169 11 14.9 1.229 11 38.7 1.364 11 13.3 1.354 11 15.7 1.102 11 11.6 104 9.09 0 3 881.8363 6.07 81.14 2643.48081

ADEVTLSEAGSTAGAAETRGAVEGAAR

PALM paralemmin-1 isoform 2 [Homo sapiens]

5064 NP_001035224 1 2 93141029 N-Term(iTRAQ4plex) 0.872 3 18.6 1.105 3 10.1 0.551 3 2.7 0.568 3 30.2 1.255 3 11.2 1.136 3 1.1 1.524 3 52.2 103 5.67 0 2 1090.6331 4.88 80.71 2180.25884

ADGNQLTLEER CD109 CD109 antigen isoform 3 precursor [Homo sapiens]

135228 NP_001153060 2 3 227430303 N-Term(iTRAQ4plex) 1.281 9 8 0.796 9 7.3 1.176 9 13.8 1.432 9 12.1 1.162 9 23.4 1.415 9 18.9 1.042 9 24.6 102 7.66 0 4 1232.6683 -4.25 20.83 2464.34463

ADGSGSVVLR LRP1 prolow-density lipoprotein receptor-related protein 1 precursor [Homo sapiens]

4035 NP_002323 2 1 126012562 N-Term(iTRAQ4plex) 1.229 20 22.6 0.973 20 18.7 1.257 20 35.1 1.206 20 16.6 1.291 20 26.2 1.402 20 20.2 1.125 20 8.6 102 5.49 0 3 945.53137 -1.1 33.13 1890.05828

ADGSYAAWLSR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

25 6 178557739;67190748

N-Term(iTRAQ4plex) 1.493 10 21.2 0.865 10 26.1 1.361 10 26.8 1.48 10 16.7 1.518 10 23.2 1.735 10 25.3 1.102 10 16.6 102 8.38 0 3 881.11816 -3.44 80.98 2641.35019

ADIEK ZC3H7B zinc finger CCCH domain-containing protein 7B [Homo sapiens]

23264 NP_060060 NP_079289

4 1 27881484 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.887 15 14.9 0.973 15 24 1.874 15 15 1.673 15 8.5 2.054 15 19 1.894 15 13.7 1.115 15 8.8 101 5.85 0 2 872.03125 2.61 81.2 1743.05522

ADIGCTPGSGK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 4 1 115298678 N-Term(iTRAQ4plex); C5(Methylthio); K11(iTRAQ4plex)

1.326 22 13.3 1.033 22 10 1.296 22 16.7 1.161 22 18.1 1.445 21 14.2 1.344 22 13.2 1.133 22 7.4 101 6.4 0 2 897.49341 -2.91 20.5 1793.97222

ADLEMQIESLKEELAYLK KRT14 keratin, type I cytoskeletal 14 [Homo sapiens]

3861 NP_000517 4 1 15431310 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K18(iTRAQ4plex)

0.401 4 30.8 0.992 4 26.1 0.503 4 36.7 0.579 4 59.5 0.486 3 59.7 0.465 3 40.7 1.008 3 3.2 99 9.11 0 3 1454.1587 -0.5 27.44 2907.30667

ADLEMQIESLTEELAYLK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

29 2 195972866 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.295 12 17.3 0.982 12 10.2 1.283 12 14.9 1.261 12 10.2 1.342 12 19.8 1.348 12 15.2 1.085 12 7.6 99 6.69 0 3 1068.5331 -5.17 34.7 2136.05889

ADLEMQIESLTEELAYLK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

10 2 195972866 N-Term(iTRAQ4plex); M5(Oxidation); K18(iTRAQ4plex)

1.427 15 46.4 0.915 14 20.7 1.289 13 32.5 1.457 14 23.5 1.403 14 41 1.428 15 22.7 1.11 14 22.1 99 8.29 0 3 1454.1587 -0.5 27.44 2923.30766

ADLFYDVEALDLESPK HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 101 1 4504489 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.57 5 3.9 0.847 5 7.6 1.413 5 4.5 1.697 5 10.1 1.443 5 16.2 1.705 5 8.9 1.013 5 3.2 98 6.67 0 3 1086.0272 -9.69 23.53 2171.05277

ADLSGITGAR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 84 1 50659080 N-Term(iTRAQ4plex) 1.424 13 8 0.994 13 12.8 1.392 13 18.5 1.355 13 10.4 1.476 13 9.4 1.513 13 9.6 1.126 13 7.6 98 6.51 0 3 1109.0546 -2.18 47.15 2217.10185

ADNFLLENTLPAQSTFTLAISAYALSLGDK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K30(iTRAQ4plex)

1.367 27 11.5 0.991 27 10.1 1.256 27 17.5 1.273 27 13.2 1.429 27 13.4 1.509 27 19.3 1.128 27 5.8 97 5.96 0 2 989.54083 -1.16 50.36 1978.08049

ADQVCINLR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C5(Methylthio)

1.312 9 10.4 1.017 9 22.3 1.344 9 6.5 1.328 9 5 1.337 9 19.8 1.431 9 29.7 1.003 9 33.3 97 8.07 0 3 1072.8694 -0.13 51.92 3216.58774

ADSEGSNSGGTWPK DLG5 disks large homolog 5 [Homo sapiens]

9231 NP_004738 3 1 95089461 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.011 5 6.7 0.963 5 18.2 0.809 5 19.5 0.854 5 2.9 1.08 5 19.8 1.245 5 11.4 1.343 5 18.3 96 7.91 0 4 1217.6587 0.98 81.47 2434.30898

ADSPMDDFFQCVNGK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 4 1 119392081 N-Term(iTRAQ4plex); M5(Oxidation); C11(Methylthio); K15(iTRAQ4plex)

1.236 8 12.6 1.068 8 29.8 1.157 8 27.1 1.103 8 17.1 1.303 8 37.4 1.302 8 18.7 1.14 8 7.6 96 7.4 0 3 995.54248 1.41 22.59 1990.07773

ADSPMDDFFQCVNGK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 34 1 119392081 N-Term(iTRAQ4plex); C11(Methylthio); K15(iTRAQ4plex)

1.345 18 11.9 0.938 18 14.5 1.22 18 13.4 1.33 18 10.9 1.341 18 18.9 1.541 18 7.7 1.117 18 8.5 95 4.99 0 3 863.45142 -0.41 43.5 1725.89792

ADSQAQLLLSTVVGVFTAPGLHLK

AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 170 1 4557287 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.293 79 15.3 0.947 79 25.4 1.217 79 28.8 1.277 79 21.3 1.362 79 24.2 1.395 79 26.3 1.141 79 23.3 95 8.48 0 3 924.12646 1.97 71.67 2770.36063

ADSVVDLLSYNVQGSGETTYDHK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 87 1 105990532 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.436 37 9.5 0.999 37 19.1 1.346 37 18.7 1.346 37 4.4 1.503 37 14.8 1.503 37 7.6 1.116 37 6.5 94 5.44 0 2 971.49664 3.26 35.63 1941.98601

ADTLTDEINFLR KRT6A keratin, type II cytoskeletal 6A [Homo sapiens]

3853 NP_005545 NP_490596

2 3 5031839 N-Term(iTRAQ4plex) 1.184 14 10.8 0.91 14 12.8 1.068 14 21.1 1.102 14 18.2 1.219 14 10.6 1.306 14 10.5 1.125 14 13.3 94 9.27 0 3 946.47601 1.71 42.14 2837.41349

ADTVAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.25 9 10.7 0.879 9 17.2 1.086 9 9.1 1.319 9 17.6 1.218 9 24.4 1.433 9 19.6 1.139 9 11.4 94 9.13 0 3 1360.6823 -4.9 26.83 2720.35526

ADVQAHGEGQEFSITCLVDEEEMK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 154 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); K24(iTRAQ4plex)

1.261 15 8.2 0.926 15 13.3 1.084 15 14.3 1.195 15 10.7 1.328 15 10.8 1.401 15 7.7 1.162 15 7.7 94 6.83 0 3 1070.023 0.46 47.91 2139.03667

ADVQAHGEGQEFSITCLVDEEEMK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 4 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); M23(Oxidation); K24(iTRAQ4plex)

1.366 18 10.8 0.927 18 16.5 1.231 18 26.1 1.331 18 30 1.375 18 14.4 1.481 18 20.6 1.157 18 13.9 93 7.95 0 3 1409.2208 1.61 45.78 2817.42752

ADVQAHGEGQEFSITCLVDEEEMKK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 17 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); K24(iTRAQ4plex); K25(iTRAQ4plex)

1.431 21 13.6 1.024 21 20.3 1.447 21 16 1.396 21 8.6 1.556 21 17.9 1.494 21 10.7 1.114 21 9.9 93 6.18 0 3 1044.0535 -0.73 32.45 2087.10063

ADVQAHGEGQEFSITCLVDEEEMKK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 2 3 156119625 N-Term(iTRAQ4plex); C16(Methylthio); M23(Oxidation); K24(iTRAQ4plex); K25(iTRAQ4plex)

1.38 11 15.5 1.088 11 22.5 1.299 11 18.3 1.219 11 13.8 1.48 11 15.2 1.449 11 17.6 1.207 11 5.3 93 6.36 0 3 1089.0759 -4.75 43.94 2177.15311

ADYVETVLDSTCSSTVQFLEYELNVLGTHK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); C12(Methylthio); K30(iTRAQ4plex)

1.62 5 4.8 0.972 5 3.4 1.437 5 4.3 1.558 5 37.2 1.748 5 7.9 1.769 5 6 1.182 5 13.8 93 6.02 0 3 1089.0759 -4.75 43.94 2193.14261

AEAQAQYSAAVAK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

156 2 31542984;262050538

N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.368 8 19.5 1.179 8 10.3 1.546 8 26.2 1.214 8 27.9 1.608 8 14.1 1.407 8 22.5 1.066 8 24.1 92 7.43 0 4 1327.7037 -1.01 65.51 2654.39028

AEATTLHVAPQGTAMAVSTFR

C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 28 1 166197660 N-Term(iTRAQ4plex) 1.22 8 10.7 1.111 8 23.7 1.207 8 13.3 1.017 8 5.6 1.347 8 12.2 1.24 8 6.2 1.135 8 3.2 92 6.05 0 2 934.98608 3 25.16 1868.9572

AEATTLHVAPQGTAMAVSTFR

C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 8 1 166197660 N-Term(iTRAQ4plex); M15(Oxidation)

1.101 2 3.6 0.853 2 19.2 0.97 2 14.5 1.137 2 4.6 1.073 2 10.6 1.258 2 8.5 1.107 2 3.8 92 3.79 0 2 890.90314 -9.48 21.26 1780.799

AECMLQQAER LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 1 167614506 N-Term(iTRAQ4plex); C3(Methylthio)

1.342 26 12.7 0.964 26 11 1.227 26 14.9 1.285 26 9.1 1.409 26 14.2 1.474 26 13.9 1.14 26 6.3 92 6.2 0 2 844.50769 -0.22 57.92 1688.00078

AEDHFSVIDFNQNIR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 86 1 70778918 N-Term(iTRAQ4plex) 1.146 7 12 1.011 7 12.2 1.082 7 22.2 1.14 7 9.6 1.238 7 10.2 1.294 7 10.3 1.167 7 5.7 90 4.75 0 2 780.44745 -0.47 25.78 1559.88762

AEDLVGK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.358 3 3.1 0.927 3 2.7 1.231 3 0 1.329 3 2.7 1.408 3 3.3 1.492 3 3.7 1.143 3 3.3 90 5.08 0 2 763.92645 -7.43 19.52 1526.84563

AEEEHLGILGPQLHADVGDK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 20 1 4557485 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.272 10 22.1 0.98 10 13.3 1.189 10 38.5 1.239 10 18 1.338 10 25.1 1.484 10 8.7 1.117 10 6.5 90 5.64 0 2 799.45532 -0.38 28.05 1597.89653

AEEHTVVLTVTGEPCHFPFQYHR

F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 5 1 145275213 N-Term(iTRAQ4plex); C15(Methylthio)

1.112 18 16.6 0.932 18 25.5 1.087 18 27.9 1.109 18 18.2 1.145 18 23.7 1.204 18 20 1.095 18 13.9 90 5.04 0 3 890.90314 -9.48 21.26 1796.81157

AEELLSR INPP5D phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform b [Homo sapiens]

3635 NP_005532 XP_935053

1 2 40254823 N-Term(iTRAQ4plex) 1.179 109 8 0.878 109 12.5 1.03 109 10.4 1.145 109 13 1.208 109 9.3 1.319 109 11.5 1.161 109 9.4 89 7.37 0 4 544.97046 1.8 23.64 1632.89865

AEFQDALEK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

233 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.219 4 5.5 0.821 4 9.2 0.998 4 7.3 1.244 4 5.8 1.162 4 13.1 1.456 4 4.9 1.141 4 2.8 89 4.42 0 2 776.42145 -3.45 23.24 1551.83733

AEFQDALEKLNMGITDLQGLR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.422 15 6.5 0.979 15 16.6 1.398 15 11.5 1.44 15 13.8 1.47 15 11.7 1.501 15 10.9 1.055 15 8.1 89 8.38 0 3 787.76044 0.62 65.93 2361.26676

AEIEYLEK SELL L-selectin precursor [Homo sapiens] 6402 NP_000646 4 1 262206315 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.429 7 7.8 0.933 7 15.3 1.277 7 18.4 1.346 7 6 1.454 7 11.2 1.534 7 6.9 1.14 7 4.7 88 5.9 0 2 787.96814 -4.21 24.26 1574.92986

AELLVTEAPSKPITVTVEEQR

HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.517 14 11.4 1.038 14 15.4 1.437 14 17.3 1.407 14 8.3 1.577 14 16 1.561 14 9.8 1.104 14 5.4 88 5.96 0 3 1019.9926 -3.36 39.54 2038.97795

AELQEGAR APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 2 1 4557321 N-Term(iTRAQ4plex) 1.31 26 15.6 0.961 26 22.9 1.157 26 21.2 1.227 26 18.4 1.365 26 21 1.448 26 16.9 1.132 26 11.7 87 4.85 0 3 997.54059 2.71 68.13 1994.06797

AEMADQAAAWLTR C4B complement C4-B preproprotein [Homo sapiens]

721 NP_001002029 NP_000583 XP_001722858

77 4 178557739 N-Term(iTRAQ4plex) 1.523 10 3 1.145 10 18.6 1.443 10 18.5 1.332 10 8 1.658 10 14.9 1.482 10 12.7 1.129 10 3.7 87 5.19 0 2 824.96216 3.75 19.2 1648.90849

AEMADQAAAWLTR C4B complement C4-B preproprotein [Homo sapiens]

721 NP_001002029 NP_000583 XP_001722858

24 4 178557739 N-Term(iTRAQ4plex); M3(Oxidation)

1.489 20 18 1.006 20 18.7 1.493 20 25.9 1.417 20 17.5 1.486 20 25.5 1.544 20 14.6 1.139 20 6.7 87 5.39 0 2 859.99927 -1.1 34.71 1718.98284

AEMADQASAWLTR C4A complement C4-A isoform 1 preproprotein [Homo sapiens]

720 NP_009224 XP_003403837

31 2 67190748 N-Term(iTRAQ4plex) 1.356 45 12.5 0.957 45 17.8 1.211 45 20.8 1.297 45 10.8 1.402 45 24.2 1.481 45 10.7 1.15 45 11.1 86 7.13 0 3 779.42316 2.56 74.16 2336.24576

AEMADQASAWLTR C4A complement C4-A isoform 1 preproprotein [Homo sapiens]

720 NP_009224 XP_003403837

2 2 67190748 N-Term(iTRAQ4plex); M3(Oxidation)

1.499 4 6.2 1.074 4 10.5 1.441 4 11.2 1.372 4 7.9 1.688 4 8.8 1.552 4 2 1.087 4 5.9 85 7.73 0 3 1127.1544 7.1 36.27 2253.29276

AEPLAFTFSHDYK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 12 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.289 2 13.1 1.079 2 11 1.21 2 21.4 1.121 2 32.9 1.462 2 4.1 1.355 2 6.9 1.208 2 25.7 85 8.98 1 4 1014.5505 3.29 48.02 3041.62612

AEPPKAPEQEQAAPGPAAGGEAPK

BASP1 brain acid soluble protein 1 [Homo sapiens]

10409 NP_006308 1 1 30795231 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K24(iTRAQ4plex)

1.304 25 10.9 1.007 25 15.1 1.209 25 20.6 1.247 25 8 1.37 25 15 1.362 25 10 1.087 25 5.9 85 5.43 0 2 765.92273 -1.6 27.44 1530.84026

AEQCCEETASSISLHGK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 14 1 4502511 N-Term(iTRAQ4plex); C4(Methylthio); C5(Methylthio); K17(iTRAQ4plex)

1.209 10 12.4 0.884 10 3.7 1.068 10 13.7 1.291 10 22 1.142 10 9.1 1.333 10 15 1.084 10 13.3 84 5.86 0 3 922.51343 0.45 69.86 1844.01798

AESPEVCFNEESPK AFM afamin precursor [Homo sapiens] 173 NP_001124 42 1 4501987 N-Term(iTRAQ4plex); C7(Methylthio); K14(iTRAQ4plex)

1.291 18 8.2 0.938 18 10.1 1.208 18 7.7 1.265 18 7.3 1.366 18 13.5 1.426 18 10.7 1.145 18 5.7 84 7.44 0 3 1129.1157 0.97 43.85 2257.22124

AETECQNTEYQQLLDIK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

12 2 195972866 N-Term(iTRAQ4plex); C5(Methylthio); K17(iTRAQ4plex)

1.262 5 17.1 0.907 5 21.1 1.081 5 26.5 1.247 5 8.3 1.31 5 36.9 1.443 5 12.1 1.129 5 11.1 83 5.4 0 3 737.90881 -0.04 12.24 1474.81363

AETGDK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.311 6 8.9 1.025 6 7 1.254 6 0.8 1.205 6 4.3 1.436 6 10 1.384 6 14.3 1.148 6 8.9 83 7.02 0 3 907.46246 -10.31 24.3 1813.91874

AETGDTVLK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 3 4507875 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.431 19 6.2 1.021 19 6.6 1.365 19 8.8 1.319 19 6.5 1.499 19 9.9 1.519 19 6.4 1.13 19 4.5 83 6.27 0 2 960.49524 -0.67 46.37 1919.9832

AEVDDVIQVR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 1.353 44 14 0.998 44 14.5 1.275 44 19.4 1.237 44 11.7 1.472 44 15.6 1.438 44 12.7 1.141 44 5.5 83 5.49 0 2 798.94641 -1.3 53.32 1596.88555

AFALWSAVTPLTFTR MMP9 matrix metalloproteinase-9 preproprotein [Homo sapiens]

4318 NP_004985 1 1 74272287 N-Term(iTRAQ4plex) 1.39 41 11.2 0.97 41 8.2 1.303 41 22.3 1.352 41 17.5 1.448 41 15.7 1.479 41 13 1.158 41 11.8 83 6.7 0 3 1090.6331 4.88 80.71 2196.24369

Page 2: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

AFDICPLVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 17 2 38016947 N-Term(iTRAQ4plex); C5(Methylthio); K9(iTRAQ4plex)

1.121 12 6.4 0.999 12 6.8 1.052 12 9.4 1.129 12 16.1 1.1 12 10.3 1.191 12 12.5 1.112 12 6.4 82 4.96 0 2 868.48773 -1.7 57.98 1735.96965

AFENVTDLQWLILDHNLLENSK

LUM lumican precursor [Homo sapiens] 4060 NP_002336 2 1 4505047 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.442 4 9.5 0.976 4 18.5 1.367 4 10.6 1.456 4 10.9 1.533 4 6.1 1.586 4 12.3 1.099 4 2.5 82 5.04 0 2 871.00769 -1.01 33.39 1741.0081

AFIQLWAFDAVK AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 469 1 4502067 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.075 14 10.5 0.962 14 14.6 0.987 14 23 1.074 14 18.2 1.123 14 25.8 1.216 14 11.5 1.125 14 6.6 81 5.47 0 2 813.95856 -1.81 50.92 1626.90984

AFLLTPR APOM;APOM

apolipoprotein M isoform 2 [Homo sapiens];apolipoprotein M isoform 2 [Homo sapiens]

55937;55937

NP_001243098;NP_001243098

1 2 22091452;371873523

N-Term(iTRAQ4plex) 0.461 1 0.788 1 0.396 1 0.502 1 0.429 1 0.544 1 1.084 1 81 6 0 2 1086.0272 -9.69 23.53 2155.0811

AFLQLCHLKK ZNF408 zinc finger protein 408 isoform 2 [Homo sapiens]

79797 NP_001171680 2 2 296080783 N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex); K10(iTRAQ4plex)

0.605 3 58.3 0.875 3 5.1 0.51 3 38.3 0.603 3 75.6 0.607 3 43.5 0.718 3 82.2 1.166 3 1.6 81 4 0 2 871.92065 1.01 35.77 1742.82988

AFPALTSLDLSDNPGLGER CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 13 1 4557417 N-Term(iTRAQ4plex) 1.557 6 9.6 0.995 6 7.4 1.419 6 18.3 1.445 6 7.5 1.629 6 21.6 1.599 6 12.5 1.101 6 6 80 8.2 1 3 1333.7029 3.71 46.03 2666.39188

AFQVWSDVTPLR MMP2 72 kDa type IV collagenase isoform b [Homo sapiens]

4313 NP_001121363 2 2 189217853 N-Term(iTRAQ4plex) 0.887 3 4.4 1.016 3 17.5 0.763 3 1.6 0.751 3 19.1 1.089 3 7.6 1.003 3 6.9 1.275 3 18.5 79 6.32 0 3 1298.3602 -3.48 71.96 3893.06614

AFQYHSK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 2 3 4505881 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.221 3 4.3 0.734 3 17.2 1.155 3 2.6 1.411 3 6.1 1.082 3 5.8 1.474 3 31.3 1.045 3 15.4 79 7.74 0 4 787.40509 -9.77 28.62 2360.2311

AFSSYQK AFM afamin precursor [Homo sapiens] 173 NP_001124 4 1 4501987 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.259 2 1.9 0.76 2 23.2 1.007 2 20.3 1.325 2 2.8 1.213 2 4.8 1.594 2 18.2 1.204 2 15.4 79 4.35 0 4 888.01709 5.77 18.33 1775.03335

AFSVNIFK LAMP1 lysosome-associated membrane glycoprotein 1 precursor [Homo sapiens]

3916 NP_005552 2 1 112380628 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.253 36 11.4 1.013 36 15.1 1.207 36 19.9 1.196 36 9.1 1.355 36 18 1.372 36 10.5 1.135 36 6.4 79 3.86 0 2 679.91663 -1.97 43.51 1358.8239

AFTECCVVASQLR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 81 2 38016947 N-Term(iTRAQ4plex); C5(Methylthio); C6(Methylthio)

1.269 16 8.9 0.931 16 19.2 1.151 16 17.6 1.247 16 7 1.293 16 16.8 1.414 16 7.2 1.141 16 2.9 79 3.94 0 2 624.34576 0.67 13.92 1247.68425

AFTNSK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 3 3 66932947 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.414 3 28.4 0.913 3 17.6 0.366 3 32.8 0.4 3 13.5 0.428 3 41.9 0.468 3 21.9 1.169 3 4.9 79 4.78 0 2 734.90131 2.27 17.28 1468.79534

AFVLSSVDELEQQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex) 1.394 11 6.5 1.1 11 19.5 1.382 11 10.6 1.303 11 3.4 1.559 11 11.5 1.442 11 8.8 1.158 11 6.6 79 4.3 0 3 734.90131 2.27 17.28 1484.78606

AFVVDMMER VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex) 1.102 11 13.1 0.989 11 9.7 0.982 11 15.4 1.072 11 14.1 1.136 11 14.6 1.241 11 9.9 1.161 11 5.5 79 6.12 0 3 631.01581 0.65 27.43 1891.03287

AFVVDMMER VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 1 1 89191868 N-Term(iTRAQ4plex); M7(Oxidation)

1.623 8 11.8 0.929 8 14.6 1.482 8 9.7 1.632 8 11.8 1.603 8 20 1.709 8 18.7 1.097 8 5.3 78 6.33 0 3 1162.1146 -1.16 66.15 2323.2222

AFWLDVSHNR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 6 2 4826772 N-Term(iTRAQ4plex) 1.508 7 1.7 0.909 7 3.6 1.285 7 13.2 1.336 7 8.5 1.636 7 20.1 1.753 7 9.8 1.239 7 13.6 78 6.83 0 3 1296.1729 3.37 53.52 2591.33878

AFYYPEEAGLAFGGPGSSR DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 3 1 116534900 N-Term(iTRAQ4plex) 1.38 8 9.7 1.011 8 18 1.311 8 15 1.221 8 17.6 1.448 8 16.8 1.47 8 8.2 1.14 8 6.3 78 4.09 0 3 823.01263 0.06 53.39 1645.01584

AGAEPASER KNG1 kininogen-1 isoform 2 precursor [Homo sapiens]

3827 NP_000884 14 2 4504893 N-Term(iTRAQ4plex) 1.662 4 4.3 1.021 4 16.5 1.6 4 10.3 1.546 4 2.3 1.809 4 11 1.764 4 2.4 1.132 4 1.2 78 4.71 0 2 682.90924 6.14 37.52 1364.79607

AGALQLLLVGDK PLTP phospholipid transfer protein isoform c precursor [Homo sapiens]

5360 NP_001229849 8 4 339275807 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.407 6 5.8 1.043 6 10.6 1.289 6 11.5 1.351 6 4.1 1.446 6 12.7 1.448 6 10.1 1.152 6 11.2 77 5.57 0 3 1016.9679 -10.12 24.25 2032.92862

AGCVAESTAVCR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex); C3(Methylthio); C11(Methylthio)

1.391 19 12.1 0.984 19 14.1 1.264 19 15 1.253 19 13.9 1.52 19 18.1 1.497 19 10.1 1.186 19 15.3 77 7.1 1 3 1471.1957 3.41 34.73 2941.38242

AGDEAVFAQYDSFHVDSAAEYYR

TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 2 188528648 N-Term(iTRAQ4plex) 1.9 14 14.8 1.049 14 7 1.81 14 14.6 1.843 14 11.7 2.05 14 22.2 2.028 14 11.7 1.12 14 6.4 77 4.82 0 3 790.45825 -1.79 34.13 1579.90923

AGDFLEANYMNLQR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 153 1 115298678 N-Term(iTRAQ4plex) 1.604 9 7.1 0.998 9 10.5 1.488 9 12.3 1.454 9 6.9 1.673 9 12.1 1.631 9 7.6 1.126 9 4 77 4.58 0 2 755.90674 -2.78 17.76 1510.8062

AGDFLEANYMNLQR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 26 1 115298678 N-Term(iTRAQ4plex); M10(Oxidation)

1.342 15 9.4 1.071 15 12.2 1.299 15 15.2 1.238 15 9.4 1.458 15 14 1.414 15 5.6 1.126 15 3.2 76 4.47 0 2 713.88464 3.56 25.06 1426.76201

AGELEVFNGYFVHFFAPDNLDPIPK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 92 1 70778918 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

0.48 2 8.7 0.804 2 27.4 0.402 2 23 0.499 2 4.3 0.467 2 19.2 0.581 2 7.9 1.163 2 3.6 76 4.23 0 2 672.85052 -9.98 15.48 1344.69377

AGEQDATIHLK NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 4 5 115529482 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.662 6 7.6 0.946 6 11.4 1.571 6 18 1.579 6 10.8 1.795 6 7.5 1.879 6 5.8 1.217 6 7.9 76 12.05 1 3 1015.2326 1.43 51.7 3043.68326

AGEQVTYTCATYYK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 38 1 62739186 N-Term(iTRAQ4plex); C9(Methylthio); K14(iTRAQ4plex)

1.383 6 6.6 0.992 6 14.5 1.29 6 18.6 1.311 6 6.2 1.465 6 20.2 1.514 6 4.8 1.13 6 4.6 76 4.74 0 2 747.42181 -6.06 29.39 1493.83635

AGEVQEPELR AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 18 1 4502337 N-Term(iTRAQ4plex) 1.753 11 10.6 1.019 11 14.3 1.714 11 8.9 1.658 11 8.7 1.812 11 19 1.851 11 13 1.102 11 6.7 75 5.27 0 3 1006.5715 -3.06 39.79 2012.13579

AGFAGDDAPR ACTB;ACTG2

actin, cytoplasmic 1 [Homo sapiens];actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

60;72 NP_001092;NP_001606

2 11 4501885;4501889

N-Term(iTRAQ4plex) 0.486 6 4.9 1.064 6 14.7 0.459 6 13.1 0.438 6 13.2 0.54 6 14.3 0.506 6 3.1 1.123 6 5 74 5.25 0 2 790.45825 -1.79 34.13 1563.9135

AGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLR

SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 2 1 39725934 N-Term(iTRAQ4plex) 1.162 13 17.2 1.099 13 18.2 1.198 13 19.7 1.028 13 23 1.24 13 22.9 1.244 13 20.1 1.155 13 3.4 74 3.88 0 2 652.37811 -0.83 18.53 1303.75151

AGFGNQESEFWLGNENLHQLTLQGNWELR

FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 56 2 27754776 N-Term(iTRAQ4plex) 1.402 8 48.9 0.929 8 13.8 1.227 8 52.5 1.372 8 46.9 1.429 8 45.9 1.551 8 44.9 1.144 8 5.7 74 4.45 0 2 813.95856 -1.81 50.92 1642.89763

AGFSWIEVTFK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

187 2 31542984;262050538

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.425 71 18.8 0.948 68 20.4 1.352 70 28.7 1.369 68 25.3 1.508 70 22.4 1.525 69 23.6 1.106 70 19.2 73 8.4 0 3 1632.8403 0.72 64.87 3264.67339

AGGSWDLAVQER CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

20 1 256217721 N-Term(iTRAQ4plex) 1.999 2 24 0.881 2 7.2 1.75 2 20.8 1.987 2 13.5 2.009 2 33.4 2.28 2 25.8 1.147 2 12 73 4.17 0 3 866.94098 -6.1 16.38 1732.88395

AGHIAWTSSGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.255 17 7.4 0.991 17 6.5 1.176 17 7.5 1.188 17 8.9 1.284 17 7 1.359 17 7.8 1.092 17 4.7 73 4.57 0 2 650.92523 -0.85 33.13 1300.84319

AGLAASLAGPHSIVGR SOD3 extracellular superoxide dismutase [Cu-Zn] precursor [Homo sapiens]

6649 NP_003093 6 1 118582275 N-Term(iTRAQ4plex) 1.242 4 11.3 0.927 4 10.3 1.117 4 15.3 1.207 4 5.3 1.274 4 16.7 1.423 4 7.8 1.154 4 3.2 73 5.42 0 3 1089.0759 -4.75 43.94 2209.14255

AGLLRPDYALLGHR PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 10 1 156616294 N-Term(iTRAQ4plex) 1.082 5 7.5 0.851 5 8.6 0.948 5 7.4 1.035 5 8.1 1.073 5 17.1 1.26 5 12.2 1.143 5 8.6 72 7.16 0 3 1161.0862 1.66 16.34 2321.16684

AGLQAFFQVQECNK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 43 1 4557485 N-Term(iTRAQ4plex); C12(Methylthio); K14(iTRAQ4plex)

1.32 20 5.8 0.933 20 11.3 1.18 20 11.7 1.275 20 6.5 1.341 20 12.1 1.426 20 5.5 1.134 20 2.2 72 4.6 0 3 460.57281 0.2 19 1379.70389

AGPHCPTAQLIATLK PF4V1;PF4 platelet factor 4 variant precursor [Homo sapiens];platelet factor 4 precursor [Homo sapiens]

5197;5196 NP_002611;NP_002610

22 2 4505735;4505733

N-Term(iTRAQ4plex); C5(Methylthio); K15(iTRAQ4plex)

1.351 173 16 0.941 170 19.9 1.225 171 22.2 1.29 169 20.4 1.375 173 20.1 1.475 170 22.8 1.125 172 16.5 72 8.39 0 3 1194.217 3.54 63.64 2387.42681

AGQLSVK C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 4 1 166197660 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.444 37 12.1 1.002 37 15.3 1.37 37 17.9 1.36 37 5.4 1.49 37 17.5 1.531 37 5.2 1.12 37 5.5 72 5.01 0 2 766.92938 -3.15 43.26 1532.85893

AGRGLSGPCRPPPPPQARGLLTEIR

STK17A serine/threonine-protein kinase 17A [Homo sapiens]

9263 NP_004751 1 1 109255245 N-Term(iTRAQ4plex); C9(Methylthio)

1.004 6 11.3 0.939 6 6 0.9 6 5.4 0.98 6 9.8 1.027 6 12.7 1.09 6 18.6 1.115 6 4.5 72 4.2 0 2 752.35309 -4.23 39.59 1503.70561

AGSVFGEISLLAAGGGNRR CNGB3 cyclic nucleotide-gated cation channel beta-3 [Homo sapiens]

54714 NP_061971 2 1 116642889 N-Term(iTRAQ4plex) 1.39 16 17.4 1.028 16 15.6 1.313 16 23.6 1.333 16 12.9 1.456 16 25.3 1.45 16 13.3 1.133 16 7.1 72 5.54 0 2 953.04846 -2.07 58.1 1905.08965

AGTELVNFLSYFVELGTQPATQ

APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 5 1 4502149 N-Term(iTRAQ4plex) 1.256 11 6.3 1.039 11 9.7 1.217 11 14.4 1.148 11 4.5 1.368 11 13.6 1.302 11 6.8 1.117 11 3.7 72 3.48 0 2 667.40613 -2.44 35.14 1333.80498

AGTFFWSVVIPHER ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 2 3 91823602 N-Term(iTRAQ4plex) 1.423 11 3.8 0.926 11 11.3 1.271 11 6.5 1.401 11 8.2 1.442 11 5.6 1.586 11 8.9 1.132 11 3.1 71 3.59 0 2 668.39246 1.02 31.27 1335.77764

AGTLDLSLTVQGK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 13 1 40317626 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.315 20 14.1 0.873 20 13.1 1.199 20 17.8 1.306 20 11.8 1.29 20 16.5 1.479 20 17.9 1.125 20 5.3 71 4.79 0 4 978.07123 2.45 56.96 1955.13518

AGVDICRVSASWSYTAFVTRGGR

RCCD1 RCC1 domain-containing protein 1 [Homo sapiens]

91433 NP_291022 1 1 63054858 N-Term(iTRAQ4plex); C6(Methylthio)

1.15 17 6.8 0.915 17 10 1.027 17 10.8 1.104 17 11 1.18 17 9.1 1.283 17 5.4 1.161 17 3.1 71 5.2 0 3 434.2431 1.32 22.24 1300.7175

AGVLFGMSDR DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex) 1.673 2 16.1 0.999 2 20 1.608 2 19.1 1.61 2 0.8 1.739 2 33.2 1.742 2 12.6 1.082 2 13.5 70 5.28 0 2 979.5061 -5.15 46.19 1958.00493

AGYAFEYLIETLNDSSHK IREB2 iron-responsive element-binding protein 2 [Homo sapiens]

3658 NP_004127 XP_039114

1 1 41352693 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.392 5 2.5 1.008 5 9.5 1.308 5 8 1.269 5 0.9 1.487 5 6.4 1.467 5 0.8 1.157 5 2.6 70 3.76 0 2 619.85883 9.71 15.15 1238.69682

AHFSPSNIILDFPAAGSAAR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 2 13325075 N-Term(iTRAQ4plex) 1.344 81 12.7 0.914 81 19.5 1.223 80 16.7 1.302 79 16.5 1.393 80 18.7 1.502 79 13.7 1.128 80 12.9 70 8.6 0 3 990.18927 4.97 46.29 2968.55326

AHLDIAGSLEGHLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 218 1 105990532 N-Term(iTRAQ4plex) 1.285 9 7.8 0.949 9 6.8 1.173 9 7.7 1.266 9 10.4 1.338 9 17.3 1.446 9 15 1.125 9 4.3 70 5.14 0 3 452.88037 -5.11 19.67 1356.63432

AHLLSLVDVMQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex) 1.334 8 15.2 0.85 8 12.6 1.288 8 30.7 1.29 8 18.7 1.485 8 23 1.395 8 31.4 1.139 8 14.9 70 9.14 2 3 1411.7524 2.79 39.69 2822.50119

AHLNIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.238 2 2.7 1.109 2 7.3 1.265 2 3.9 1.141 2 3.4 1.346 2 1.4 1.214 2 8.7 1.064 2 5.3 70 7.11 0 2 971.03424 -4.33 19.97 1941.0612

AHTDVGPGPESSPVLVR PTPRF receptor-type tyrosine-protein phosphatase F isoform 2 precursor [Homo sapiens]

5792 NP_569707 2 2 109633039 N-Term(iTRAQ4plex) 1.358 26 7 1.026 26 11.6 1.316 26 9.8 1.242 26 9.3 1.465 26 10.7 1.459 26 14 1.139 26 14.5 69 8.64 0 3 1410.7355 0.1 57.49 2820.46367

AHVSFKPTVAQQR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 1 1 70778918 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.339 10 8.1 0.906 10 6.3 1.193 10 10.2 1.319 10 7.4 1.32 10 9.6 1.495 10 6.6 1.139 10 2.2 68 4.35 0 2 660.84857 1.7 17.22 1320.68987

AIAYSSLSQSYLYIDWTDNHK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 10 2 38016947 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.217 1 1.206 1 1.315 1 1.09 1 1.37 1 1.136 1 1.042 1 68 4.71 0 2 789.36505 1.16 16.04 1577.72283

AIDEDCSQYEPIPGSQK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 23 1 4557389 N-Term(iTRAQ4plex); C6(Methylthio); K17(iTRAQ4plex)

1.271 4 6.5 0.843 4 1.7 1.081 4 10.5 1.283 4 9 1.26 4 7.8 1.457 4 2.2 1.157 4 10.2 67 9.98 0 3 979.52985 4.81 62.64 2936.57499

AIEDYINEFSVR C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 24 1 4502511 N-Term(iTRAQ4plex) 1.333 7 12.1 1.062 7 10.3 1.25 7 22.8 1.263 7 2.3 1.414 7 18.2 1.437 7 4.2 1.142 7 4.4 67 4.28 0 2 655.36182 -14.58 21.58 1309.73454

AIFYMNNPSR FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 7 1 58331240 N-Term(iTRAQ4plex) 1.29 15 11.6 0.995 15 18.5 1.204 15 22.9 1.276 15 8.1 1.326 15 23.5 1.407 15 9.4 1.134 15 6.2 66 4.41 0 3 953.96014 -4.4 29.73 1906.9299

AIGYLNTGYQR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 10 1 66932947 N-Term(iTRAQ4plex) 1.006 7 21.7 0.959 7 43.1 0.938 7 18.4 0.995 7 30.4 1.219 7 39 1.037 7 31.6 1.205 7 41.9 66 6.43 0 3 1290.0142 3.01 78.28 3868.03708

AIHLDLEEYR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 2 1 21071039 N-Term(iTRAQ4plex) 1.431 45 7 0.983 45 8.7 1.281 45 7.7 1.351 45 9.4 1.508 45 8.2 1.548 45 7.4 1.156 45 6.7 66 5.82 0 3 519.31543 1.85 37.32 1555.93467

AILQSGSFNAPWAVTSLYEAR

BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 6 1 4557351 N-Term(iTRAQ4plex) 1.435 13 6.4 1.066 13 26.9 1.35 13 19.5 1.267 13 8.2 1.454 13 14.1 1.523 13 8.2 1.17 13 4 66 3.69 0 2 633.8233 -1.81 8.11 1266.64116

AIMEK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 2 3 73858568 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.13 5 9.5 1.06 5 7.4 1.101 5 7.2 1.038 5 4.7 1.232 5 9.2 1.194 5 4 1.134 5 31.8 65 6.43 1 3 739.0993 -0.38 74.2 2215.28336

AIPDLTAPVAAVQAAVSNLVR

VCL vinculin isoform VCL [Homo sapiens]

7414 NP_003364 2 2 4507877 N-Term(iTRAQ4plex) 0.464 29 32.1 0.947 29 25.2 0.44 27 40.3 0.422 28 30.3 0.463 29 48.7 0.491 29 18.9 1.105 28 28.3 65 8.17 0 3 1632.8403 0.72 64.87 3248.68283

AIPSPPTEVSIR MERTK tyrosine-protein kinase Mer precursor [Homo sapiens]

10461 NP_006334 2 1 66932918 N-Term(iTRAQ4plex) 1.579 2 5.4 1.148 2 5.5 1.557 2 2.4 1.356 2 7.9 1.835 2 2.5 1.599 2 8 1.179 2 0.1 65 3.38 0 2 627.35504 3.83 19.82 1253.70281

AIPVAQDLNAPSDWDSR SPP1 osteopontin isoform d precursor [Homo sapiens]

6696 NP_001238758 1 5 352962174 N-Term(iTRAQ4plex) 1.436 4 0.6 0.873 4 7.2 1.278 4 5.4 1.424 4 6.3 1.393 4 6.7 1.599 4 2.5 1.111 4 8.2 65 4.96 1 3 531.63397 1.7 13.74 1592.88555

AIPVTQYLK AFM afamin precursor [Homo sapiens] 173 NP_001124 44 1 4501987 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.386 4 14.1 1.062 4 22.7 1.368 4 29.2 1.312 4 3.5 1.492 4 23.7 1.428 4 2.4 1.107 4 3.1 64 4.54 0 3 733.91339 -3.47 19.12 1466.82108

AIQLTYNPDESSKPNMIDAATLK

FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); K13(iTRAQ4plex); K23(iTRAQ4plex)

1.401 11 10.4 0.966 11 9.4 1.302 11 15.8 1.4 11 3.7 1.441 11 19 1.575 11 7.7 1.131 11 5.1 63 4.8 0 3 502.23953 0.27 31.58 1504.70404

AISGGSIQIENGYFVHYFAPEGLTTMPK

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

35 2 31542984;262050538

N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.288 33 19.7 1.019 32 37.6 1.241 33 41.6 1.188 32 24.7 1.509 33 29.2 1.357 32 22.4 1.134 33 27.6 63 5.61 0 3 1377.7915 -0.98 74.23 2754.57573

AISGGSIQIENGYFVHYFAPEGLTTMPK

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

19 2 31542984;262050538

N-Term(iTRAQ4plex); M26(Oxidation); K28(iTRAQ4plex)

1.477 1 0.96 1 1.295 1 1.35 1 1.598 1 1.666 1 1.234 1 63 3.2 0 2 1025.5154 2.28 19.39 2050.02349

AISGLTIDGHAVGAK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.058 8 1.8 0.849 8 5 0.904 8 7.6 1.088 8 4 1.043 8 2.5 1.228 8 6.4 1.139 8 3.9 63 6.61 0 3 651.33685 3.37 81.28 1951.99601

AITPPHPASQANIIFDITEGNLR

FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 12 1 34734066 N-Term(iTRAQ4plex) 1.085 7 19.6 1.114 7 10.6 1.104 7 24.2 0.931 7 24.8 1.249 7 21.8 1.105 7 16.8 1.143 7 4.3 63 3.74 0 2 599.32562 -8.42 26.63 1197.653

AKDQLTCNK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

1.393 9 16.4 0.97 9 13.6 1.355 9 27.2 1.357 9 19.3 1.53 9 22.9 1.498 9 15.6 1.164 9 7.9 63 4.47 0 3 959.47601 -3.1 30.81 1917.94475

AKFEELNMDLFR HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 2 1 16507237 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.422 17 18.8 1.054 17 10 1.322 17 23.8 1.329 17 18.7 1.582 17 24 1.537 17 11.2 1.114 17 3.9 63 4.47 0 2 730.89594 -2.01 26.97 1460.78459

AKLEEQAQQIR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 4 1 4557325 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.449 3 0 1.055 3 9.6 1.348 3 0.4 1.298 3 7.3 1.533 3 7.1 1.524 3 2.5 1.137 3 4.8 63 5.23 1 3 539.99164 4.76 15.31 1617.96036

AKLPDATPTELAK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 4 2 32483410 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K13(iTRAQ4plex)

1.456 6 25.1 0.837 5 36 1.305 6 38.1 1.501 5 15 1.282 6 22.8 1.736 5 20.5 1.081 6 10.4 62 8.24 1 3 857.41724 4.75 18.27 2570.21573

AKWEMPFDPQDTHQSR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 2 1 50659080 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.388 15 6.5 1 15 15.7 1.27 15 15.4 1.302 15 4.6 1.467 15 13.6 1.467 15 4.5 1.117 15 4.7 62 4.17 0 2 683.85046 -0.29 10.58 1366.69414

ALAEDVK QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 2 13325075 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.462 23 7.7 0.968 23 10.7 1.433 23 9 1.43 23 17.3 1.553 23 16 1.545 23 12.4 1.108 23 7.5 62 5.27 0 3 1018.0609 2.02 48.29 2035.11051

ALALPPLGLAPLLNLWAKPQGR

SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 46 2 7382460 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.237 13 24.6 1.025 13 15.3 1.168 13 26.5 1.176 13 13.5 1.345 13 32.4 1.31 13 13.8 1.079 13 6.2 61 3.73 0 2 681.91431 -1.61 26.03 1362.82268

ALAQCAPPPAVCAELVR IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 12 2 62243068 N-Term(iTRAQ4plex); C5(Methylthio); C12(Methylthio)

0.7 3 1.7 1.015 3 2.4 0.601 3 22.5 0.652 3 5.5 0.742 3 0.7 0.719 3 17.5 1.223 3 2.1 61 3.9 0 2 959.47601 -3.1 30.81 1901.94914

ALASYVAACQAAGVVIEDWR

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

6 1 154146262 N-Term(iTRAQ4plex); C9(Methylthio)

1.074 1 1.007 1 0.987 1 0.98 1 1.168 1 1.16 1 1.184 1 61 4.78 0 2 849.98828 -0.05 64.64 1698.96929

ALDFAVGEYNK CST3 cystatin-C precursor [Homo sapiens]

1471 NP_000090 13 1 4503107 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.535 11 11.4 1.015 11 21.6 1.491 11 28 1.419 11 6.9 1.677 11 24.4 1.615 11 3.5 1.14 11 2.2 61 4.58 0 2 658.90735 -5.02 25.02 1316.80742

ALDLINK HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 17 1 4504489 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.394 2 22.5 0.948 2 15 1.253 2 31.7 1.322 2 16.1 1.466 2 28.8 1.547 2 13.4 1.17 2 2.6 61 5.09 0 2 961.02081 -4.1 32.01 1921.03435

ALDLSLK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 13 1 133925809 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.783 3 1.5 0.955 3 15.4 1.571 3 8.1 1.484 3 23.7 1.86 3 18.1 1.948 3 2.6 1.244 3 10.5 60 5.77 1 3 1276.6311 -5.81 17.36 2552.2529

ALDQYLMEFNACR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 14 1 4557389 N-Term(iTRAQ4plex); C12(Methylthio)

1.325 16 36.2 0.934 16 33.3 1.464 16 82.1 1.547 16 87.7 1.365 16 59.2 1.465 16 33 0.981 16 82.7 60 7.7 0 4 1557.3967 0.56 81.72 3113.78652

ALDQYLMEFNACR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 8 1 4557389 N-Term(iTRAQ4plex); M7(Oxidation); C12(Methylthio)

1.301 3 18 1.02 3 25.6 1.113 3 14.6 1.336 3 2.5 1.319 3 7.6 1.513 3 1.6 1.133 3 0.9 59 3.54 0 2 611.34589 -6.9 15.95 1221.68474

ALEEANADLEVK KRT16;KRT14

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens]

3868;3861 NP_005548;NP_000517

2 6 24430192;15431310

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.191 1 1.074 1 2.152 1 2.003 1 2.392 1 2.226 1 1.111 1 59 4.09 0 2 677.89709 -4.72 20.77 1354.78691

ALEESNYELEGK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

16 2 195972866 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.312 3 2.2 0.944 3 5.8 1.238 3 4.1 1.275 3 14.1 1.434 3 9.3 1.427 3 8.8 1.118 3 4.3 58 4.38 0 2 805.9375 -6.44 28.46 1610.86772

ALEILQEEDLIDEDDIPVR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

89 6 178557739;67190748

N-Term(iTRAQ4plex) 1.789 1 1.09 1 1.763 1 1.618 1 1.975 1 1.813 1 1.12 1 58 4.74 0 2 763.88928 -1.1 26.8 1526.77129

ALEQDLPVNIK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 8 1 21071039 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.183 11 8.8 0.981 11 11.4 1.165 11 9 1.111 11 11.4 1.324 11 9.2 1.273 11 6.7 1.107 11 6.6 58 4.94 0 3 848.96997 1.5 29.26 1696.93071

ALFLETEQLK ALCAM CD166 antigen isoform 3 precursor [Homo sapiens]

214 NP_001230210 1 3 343168772 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.559 9 3.8 1.054 9 8.5 1.501 9 4.1 1.436 9 5.2 1.689 9 7.3 1.602 9 4 1.142 9 3.3 58 5.04 0 3 871.92065 1.01 35.77 1758.83438

ALFVSEEEK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 18 1 67782358 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.341 12 5.8 0.947 12 5.1 1.254 12 4.9 1.31 12 4.4 1.399 12 9.7 1.469 12 6.8 1.124 12 4.2 58 4.87 0 3 849.98828 -0.05 64.64 1714.9636

ALFVSEEEKK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 4 1 67782358 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K10(iTRAQ4plex)

1.311 7 8.8 1.05 7 19.2 1.254 7 17.4 1.36 7 6.4 1.385 7 8.1 1.54 7 22.4 1.136 7 3.9 58 4.7 0 3 449.25647 -0.58 19.92 1345.75156

ALGGDLASINNK LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 2 2 341915493 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.366 3 11.6 1.014 3 3.2 1.303 3 15.6 1.285 3 5 1.449 3 12.1 1.428 3 7.4 1.094 3 2.3 57 5.69 1 3 730.71997 -1.08 23.73 2190.14536

ALGHLDLSGNR LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 5 1 16418467 N-Term(iTRAQ4plex) 1.102 3 5.1 0.988 3 10 0.977 3 5.4 1.062 3 12.5 1.161 3 7.2 1.234 3 7.7 1.161 3 3.4 57 4.64 0 2 863.45142 -0.41 43.5 1709.90715

ALGISPFHEHAEVVFTANDSGPR

TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 3 1 4507725 N-Term(iTRAQ4plex) 1.408 9 8 0.98 9 7 1.314 9 18.9 1.385 9 15.8 1.429 9 15.6 1.615 9 14 1.131 9 2.8 57 4.18 0 3 452.88037 -5.11 19.67 1372.62842

ALGLVPQAHPGFLTAWPADR

B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 precursor [Homo sapiens]

374907 NP_940942 XP_351198

4 1 38348376 N-Term(iTRAQ4plex) 0.718 5 9.5 0.998 5 11.4 0.66 5 5 0.743 5 23.4 0.804 5 11.1 0.775 5 15.2 1.088 5 7.7 57 4.19 0 2 733.87115 -5.46 29.01 1466.73503

ALHFAISEYNK CST1;CST4 cystatin-SN precursor [Homo sapiens];cystatin-S precursor [Homo sapiens]

1469;1472 NP_001889;NP_001890

4 2 19882251;4503109

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.097 17 6.1 0.997 17 8.3 1.016 17 7 1.081 17 6.4 1.146 17 9.2 1.233 17 10.8 1.136 17 4.9 57 4.35 0 2 648.3363 -4.56 37.58 1295.67656

ALHQVFEHMLDVSK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 6 3 14550407 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.366 12 8.2 1.003 12 12.4 1.257 12 7.6 1.333 12 7.6 1.376 12 11.6 1.508 12 7.3 1.106 12 2.3 57 2.88 0 2 554.33636 0.19 34.05 1107.66496

ALHQVFEHMLDVSK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 4 3 14550407 N-Term(iTRAQ4plex); M9(Oxidation); K14(iTRAQ4plex)

1.07 3 3.9 0.959 3 40.7 1.124 3 38.9 1.271 3 25.9 1.219 3 39.7 1.477 3 19.6 1.115 3 4.1 57 2.97 0 2 524.33881 4.86 16.99 1047.64995

ALILGELEK OAF out at first protein homolog precursor [Homo sapiens]

220323 NP_848602 2 1 30425438 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.324 6 3.6 1.103 6 3.2 1.307 6 6 1.205 6 5.5 1.481 6 5.3 1.328 6 2.5 1.112 6 5.9 56 4.23 0 2 714.3703 -5.33 19.28 1427.73332

ALLAFQESK C4BPB C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

725 NP_001017364 4 2 62912462 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.186 5 30.6 1.006 5 25.3 1.101 5 51.1 1.189 5 12.4 1.208 5 47.9 1.315 5 8.3 1.098 5 1.5 56 4.01 0 2 606.34937 3.31 17.06 1211.6956

ALLAYAFALAGNQDK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.385 3 4 0.825 3 8.6 1.192 3 2.4 1.385 3 19.1 1.309 3 8.5 1.584 3 12.9 1.119 3 2.8 56 3.6 0 2 976.54602 0.41 81.39 1952.08476

ALLAYAFALAGNQDKR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.779 1 1.437 1 0.918 1 0.638 1 0.981 1 0.682 1 1.069 1 56 6.5 0 4 924.70703 -0.03 81.71 3695.8063

ALLAYAFSLLGK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 3 1 162809334 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.322 2 8.3 1.05 2 11.7 1.292 2 15.9 1.23 2 4.2 1.42 2 12.8 1.353 2 1.1 1.1 2 3.1 56 2.89 0 2 545.31427 2.74 16.34 1089.62126

ALLPTDYIK IRG1 PREDICTED: immune-responsive gene 1 protein homolog [Homo sapiens]

730249 XP_003403709 1 2 341913889 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.251 8 4.4 1.016 8 10.6 1.197 8 6.3 1.167 8 9 1.294 8 7.4 1.305 8 5.5 1.097 8 2.7 55 3.35 0 2 636.34827 -1.24 20.17 1271.67241

ALLSPEQR BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 2 1 168229159 N-Term(iTRAQ4plex) 1.393 14 14.1 1.092 14 14.4 1.319 14 16.9 1.248 14 10.2 1.481 14 24.4 1.443 14 12 1.115 14 6.4 54 3.83 0 2 616.87476 -2.48 18.81 1232.74407

ALLVGEHLNIIVTPK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 112 2 38016947 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.452 4 4 1.012 4 0.8 1.375 4 9.1 1.366 4 8.9 1.562 4 0.8 1.53 4 2.6 1.125 4 9.8 54 4.53 0 2 662.85876 0.22 12.48 1324.71025

ALMDETMK APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 2 1 4557325 N-Term(iTRAQ4plex); M3(Oxidation); K8(iTRAQ4plex)

0.971 1 1.211 1 1.05 1 0.867 1 1.097 1 0.906 1 1.044 1 54 0 2 584.34918 4.03 20 1167.69109

ALMDETMK APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 7 1 4557325 N-Term(iTRAQ4plex); M3(Oxidation); M7(Oxidation); K8(iTRAQ4plex)

1.415 1 1.031 1 1.405 1 1.362 1 1.469 1 1.425 1 1.046 1 53 0 2 569.84106 3.33 23.85 1138.67485

ALNHLPLEYNSALYSR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 23 1 169636415 N-Term(iTRAQ4plex) 1.39 1 1.084 1 1.38 1 1.274 1 1.517 1 1.399 1 1.099 1 53 0 2 599.32562 -8.42 26.63 1213.63323

ALNSMGQDLERPLELR DSG1 desmoglein-1 preproprotein [Homo sapiens]

1828 NP_001933 1 1 119703744 N-Term(iTRAQ4plex) 1.206 4 9.8 1.097 4 7.5 1.213 4 2.7 1.115 4 8.7 1.31 4 8.8 1.217 4 18.3 1.086 4 9.5 53 4.31 0 3 429.24078 -4.34 20.73 1285.71595

ALPAASTILHYER PAPLN papilin precursor [Homo sapiens] 89932 NP_775733 XP_370765

2 1 145309328 N-Term(iTRAQ4plex) 1.671 2 6.8 0.945 2 15.2 1.514 2 1.6 1.601 2 13.5 1.741 2 0.4 1.842 2 15.5 1.15 2 2 53 2.77 0 2 636.34827 -1.24 20.17 1287.6707

Page 3: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

ALPGEQQPLHALTR IGFBP1 insulin-like growth factor-binding protein 1 precursor [Homo sapiens]

3484 NP_000587 4 1 4504615 N-Term(iTRAQ4plex) 2.13 9 15.1 0.991 9 15.2 2.082 9 26.7 2.019 9 6.6 2.324 9 32.7 2.356 9 2.8 1.154 9 6.8 52 2.93 0 2 672.85052 -9.98 15.48 1360.7011

ALPGTPVASSQPR ISLR immunoglobulin superfamily containing leucine-rich repeat protein precursor [Homo sapiens]

3671 NP_005536 2 1 5031809 N-Term(iTRAQ4plex) 2.095 2 12.7 0.957 2 24.4 1.916 2 23 2.003 2 1.3 2.197 2 26.3 2.296 2 1.9 1.147 2 3.2 52 5.89 0 3 957.00098 0.93 47.13 1912.99509

ALPQPQNVTSLLGCTH HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 8 1 11321561 N-Term(iTRAQ4plex); C14(Methylthio)

1.394 1 1.007 1 1.363 1 1.353 1 1.436 1 1.426 1 1.054 1 52 3.86 0 3 408.90112 5.77 15.53 1224.68882

ALPTTYEK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 7 1 4502511 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.942 7 20.3 0.919 7 1 1.724 7 20.6 1.97 7 13.5 2.013 7 17.4 2.262 7 12.8 1.143 7 2.1 52 2.91 0 2 733.87115 -5.46 29.01 1482.73955

ALPVFCDMDTEGGGWLVFQR

FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 8 2 27754776 N-Term(iTRAQ4plex); C6(Methylthio)

1.226 19 11.8 1.098 19 14.8 1.218 19 15.2 1.144 19 10.2 1.359 19 16.1 1.232 19 10.3 1.1 19 5.3 51 2.96 0 2 528.85834 7.03 23.91 1056.7094

ALPVFCDMDTEGGGWLVFQR

FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 2 2 27754776 N-Term(iTRAQ4plex); C6(Methylthio); M8(Oxidation)

1.911 5 37.2 0.943 5 2 1.785 5 152.6 1.168 5 79.1 1.952 5 165.4 2.025 5 111.4 1.094 5 121.7 51 6.19 0 3 1298.3602 -3.48 71.96 3909.07724

ALQDQLVLVAAK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 48 1 4557287 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.426 2 6.3 1.069 2 4.7 1.406 2 8.4 1.316 2 3.7 1.544 2 9.1 1.445 2 4.3 1.098 2 0.6 51 0 2 537.29657 -1.06 16.93 1073.59294

ALQTEMAR MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 2 1 4557739 N-Term(iTRAQ4plex) 1.334 17 7.9 0.861 17 8 1.152 17 10 1.305 17 11.6 1.257 17 17.5 1.508 17 8.7 1.094 17 13.5 51 0 2 592.37683 3.79 52.57 1183.74639

ALQTEMAR MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 2 1 4557739 N-Term(iTRAQ4plex); M6(Oxidation)

1.16 2 3.1 0.974 2 25.3 1.116 2 13.8 1.146 2 11.2 1.18 2 4.9 1.212 2 20.2 1.058 2 8.9 51 6.17 1 3 727.04285 -2.04 23.56 2179.12003

ALSGFSLQSCR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex); C10(Methylthio)

1.35 2 10.3 0.935 2 9.5 1.222 2 16.6 1.307 2 7 1.391 2 13.6 1.488 2 4 1.138 2 3 50 4.53 0 3 622.3681 3.25 15.06 1243.72263

ALSIGFETCR CD44 CD44 antigen isoform 8 precursor [Homo sapiens]

960 NP_001189486 6 7 321400142 N-Term(iTRAQ4plex); C9(Methylthio)

1.294 3 0.4 0.902 3 7.5 1.176 3 11.6 1.203 3 5.9 1.285 3 16.3 1.343 3 2.5 1.116 3 3.3 50 3.6 0 3 570.36023 -0.65 14.13 1139.70838

ALSMCPPSPLGCELVK IGFBP5 insulin-like growth factor-binding protein 5 precursor [Homo sapiens]

3488 NP_000590 2 1 10834982 N-Term(iTRAQ4plex); C5(Methylthio); C12(Methylthio); K16(iTRAQ4plex)

1.283 3 19.8 1.142 3 11.1 1.375 3 17.4 1.218 3 12.7 1.487 3 10.2 1.239 3 3.7 1.031 3 1.8 50 5.83 0 3 592.65588 -2.42 15.46 1775.95823

ALSSEWKPEIR NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 1 5 115529482 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.235 17 11 1.017 17 18.6 1.156 17 21.2 1.17 17 5.5 1.307 17 23.7 1.373 17 10.3 1.148 17 3.4 50 3.41 0 2 606.82721 -2.63 30.81 1212.65532

ALSVVWDR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex) 1.298 2 0.5 1.031 2 13.9 1.176 2 2.7 1.141 2 16.5 1.459 2 14 1.415 2 0.2 1.241 2 16.7 50 4.28 0 3 609.34473 2.54 39.46 1826.01963

ALTDMPQMR FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex) 1.209 6 27.2 0.945 6 1.9 1.064 6 22.3 1.226 6 24.5 1.197 6 22.4 1.38 6 26.7 1.106 6 3.6 50 3.71 0 2 712.91656 2 39.03 1424.82712

ALVDTLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.331 16 4.3 0.957 16 10.9 1.234 16 5.1 1.281 16 6.2 1.407 16 6.4 1.44 16 9 1.129 16 4.6 49 3.78 0 2 613.34778 -2.87 50.07 1225.68974

ALVEGVDQLFTDYQIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 73 2 38016947 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.284 2 16.8 0.919 2 16 1.152 2 24.6 1.254 2 8.4 1.316 2 24.6 1.432 2 8.4 1.142 2 0 49 3.23 0 2 523.78937 0.32 11.93 1046.57146

ALVEQGFTVPEIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 35 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.403 1 0.864 1 1.218 1 1.41 1 1.396 1 1.616 1 1.146 1 49 3.56 1 3 520.62897 -6.68 15.99 1559.87235

ALVFVDNHDNQR AMY2A pancreatic alpha-amylase precursor [Homo sapiens]

279 NP_000690 XP_003960156

4 3 4502085 N-Term(iTRAQ4plex) 1.279 9 9.1 1.022 9 13.6 1.179 9 1.9 1.179 9 5.1 1.348 9 9.9 1.344 9 7.8 1.12 9 6.1 49 3.82 0 2 671.85822 -0.1 17.07 1342.70915

ALVQQMEQLR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 15 1 71773110 N-Term(iTRAQ4plex) 1.361 2 8.2 1.008 2 26.4 1.311 2 10.4 1.3 2 15.7 1.425 2 32 1.413 2 5.3 1.087 2 21.1 49 8.16 0 3 946.47009 -15.01 45.66 2837.39573

ALVQQMEQLR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 20 1 71773110 N-Term(iTRAQ4plex); M6(Oxidation)

1.125 2 3.8 1.075 2 18.9 0.997 2 26.8 0.928 2 7.6 1.335 2 3.8 1.242 2 15 1.338 2 22.8 48 5.3 0 4 389.95517 -6.56 18.06 1556.79885

ALWEKPFISSR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 4 1 21361302 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.322 4 3.3 0.954 4 8.6 1.209 4 7.1 1.274 4 3.1 1.375 4 7.6 1.456 4 1.6 1.162 4 1.9 48 3.13 0 2 553.32227 3.49 20.43 1105.63725

ALYCEL PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 1 3 19923106 N-Term(iTRAQ4plex); C4(Methylthio)

1.174 4 22.8 0.996 4 15.2 1.043 4 19.9 1.158 4 16.6 1.19 4 32.6 1.321 4 17 1.069 4 14.6 48 4.93 0 3 401.55225 1.92 14.93 1202.64219

ALYLQYTDETFR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 267 1 4557485 N-Term(iTRAQ4plex) 1.323 8 2.9 0.977 8 3.3 1.241 8 3 1.221 8 2.7 1.399 8 2.5 1.402 8 5.8 1.128 8 2.2 48 3.41 0 2 559.30127 -1.57 19.8 1117.59709

ALYVHGGYK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 3 21450863 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.75 8 12.2 0.768 8 10.8 1.48 8 4.9 1.937 8 12.2 1.668 8 9.6 2.104 8 13.3 1.069 8 6 47 5.71 0 3 651.33685 3.37 81.28 1967.98825

ALYWVNGQVPDGVSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.883 4 30.5 1.086 4 21.8 1.01 4 14 1.076 4 65 0.953 4 4.2 0.627 4 34.5 0.651 4 84.4 47 8.25 1 4 830.91766 0.64 64.46 3320.64882

ALYYDLISSPDIHGTYK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 30 1 39725934 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.281 20 15.9 0.972 20 13.3 1.229 20 25.2 1.234 20 13 1.333 20 15.8 1.508 20 12 1.128 20 6.5 46 3.43 0 2 797.95532 -3.12 41.45 1594.90337

AMAVEDIISR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 14 1 4557389 N-Term(iTRAQ4plex) 1.278 10 7.8 1.059 10 8.7 1.259 10 8.4 1.214 10 3.5 1.392 10 10.4 1.335 10 6.5 1.126 10 3.3 46 0 2 545.34692 -4.13 22.39 1089.68852

AMAVEDIISR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 6 1 4557389 N-Term(iTRAQ4plex); M2(Oxidation)

1.297 1 1.157 1 1.406 1 1.216 1 1.392 1 1.203 1 0.989 1 46 6.39 1 4 811.65826 4.71 37.2 3243.61123

AMCQNGK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 1 1 5031695 N-Term(iTRAQ4plex); C3(Methylthio); K7(iTRAQ4plex)

1.37 26 9.7 1.005 26 9.5 1.261 26 11.7 1.316 26 11 1.419 26 9.8 1.457 26 12.4 1.123 26 3.3 46 0 2 538.35938 -0.31 36.09 1075.71147

AMTSNVASVQCDNSDKFPVYK

GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 2 1 291190772 N-Term(iTRAQ4plex); C11(Methylthio); K16(iTRAQ4plex); K21(iTRAQ4plex)

1.288 11 3.5 1.006 11 8.7 1.183 11 9.5 1.221 11 5.2 1.341 11 7 1.34 11 6.8 1.138 11 3.9 46 3.65 0 2 589.81616 -3.06 26.89 1178.62505

ANEGTVGVSAATER ALPL alkaline phosphatase, tissue-nonspecific isozyme isoform 3 [Homo sapiens]

249 NP_001170991 4 3 294660772 N-Term(iTRAQ4plex) 1.628 2 1.6 0.991 2 4.8 1.528 2 3.1 1.542 2 1.7 1.714 2 4.8 1.73 2 0 1.122 2 1.7 46 5 0 3 694.90704 -5.2 18.51 1388.80681

ANFDAQQFAGTWLLVAVGSACR

C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 29 1 166197660 N-Term(iTRAQ4plex); C21(Methylthio)

1.363 6 6.6 0.944 6 13.8 1.206 6 7.8 1.315 6 9.6 1.33 6 14.6 1.441 6 10.5 1.093 6 1.8 46 2.75 0 2 613.34778 -2.87 50.07 1241.68877

ANLFNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.173 1 1.133 1 1.16 1 1.024 1 1.343 1 1.185 1 1.158 1 45 6.36 1 4 556.80762 9.98 28.56 2224.20864

ANLFNKLVTELR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.185 3 6.8 0.966 3 3 1.065 3 4.7 1.125 3 7 1.242 3 5.8 1.237 3 0.1 1.157 3 1.1 45 0 2 627.82214 8.03 27.74 1254.63701

ANSFLGEK C4A complement C4-A isoform 1 preproprotein [Homo sapiens]

720 NP_009224 XP_003403837

7 4 67190748 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.035 3 3.6 1.081 3 25.4 1.083 3 6.7 0.997 3 7.5 1.207 3 2.5 1.117 3 7 1.134 3 5.3 45 0 2 562.83466 5.89 17.47 1124.66203

ANTFLEEVRK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 1 1 4503635 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.438 2 23.6 0.879 2 31.3 1.276 2 42.1 1.453 2 9.8 1.439 2 36.2 1.638 2 4.5 1.127 2 5.3 45 0 2 477.77997 2.92 18.33 954.55266

ANTVQEATFQMELPK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

152 2 31542984;262050538

N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.394 7 4.6 0.882 7 8 1.226 7 5.2 1.438 7 5.2 1.38 7 7 1.599 7 3.8 1.103 7 3.5 45 0 2 452.7702 -1.2 2.57 904.53313

ANTVQEATFQMELPK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

21 2 31542984;262050538

N-Term(iTRAQ4plex); M11(Oxidation); K15(iTRAQ4plex)

1.338 6 7.8 0.995 6 8.8 1.237 6 12.1 1.24 6 1.9 1.434 6 16.9 1.413 6 3 1.145 6 3.4 44 2.95 0 2 535.29706 -1.13 9.99 1069.58794

ANVFVQLPR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 18 2 4826772 N-Term(iTRAQ4plex) 1.872 5 11.4 1.078 5 15.3 1.766 5 13.4 1.706 5 21.4 1.994 5 5.3 1.85 5 28.1 1.124 5 7.4 44 5.82 0 3 890.90314 -9.48 21.26 1812.80436

APADLR C4B complement C4-B preproprotein [Homo sapiens]

721 NP_001002029 NP_000583 XP_001722858

5 2 178557739 N-Term(iTRAQ4plex) 1.217 2 10.8 0.906 2 2.5 1.114 2 7.8 1.231 2 10.3 1.204 2 11.4 1.33 2 13.8 1.081 2 3.5 44 3.95 0 3 468.26379 6.18 15.71 1402.76227

APAVAEENPK IGFBP6 insulin-like growth factor-binding protein 6 precursor [Homo sapiens]

3489 NP_002169 1 1 11321593 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1 2 9.8 0.602 2 4.8 0.725 2 8.4 1.205 2 3.6 0.877 2 14.2 1.457 2 9.4 1.209 2 5.8 44 3.25 0 2 503.81076 0.7 8.19 1006.61424

APCITDWQQEDGTVHR IL6ST interleukin-6 receptor subunit beta isoform 1 precursor [Homo sapiens]

3572 NP_002175 2 1 28610147 N-Term(iTRAQ4plex); C3(Methylthio)

1.353 1 0.991 1 1.205 1 1.215 1 1.489 1 1.502 1 1.236 1 43 3.58 0 2 587.77673 -0.31 32.06 1174.54619

APDLQDLPWQVK PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 2 2 4506121 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.304 2 1.4 0.901 2 2.4 1.15 2 3.3 1.276 2 1 1.329 2 1.8 1.475 2 0.6 1.156 2 1.6 43 4.79 0 3 725.88342 2.49 18.38 1450.76154

APELPNTSSSPSLKMSSCVPRPPSHGGPTR

SOX13 transcription factor SOX-13 [Homo sapiens]

9580 NP_005677 1 1 41406089 N-Term(iTRAQ4plex); K14(iTRAQ4plex); C18(Methylthio)

1.266 1 0.73 1 1.001 1 1.372 1 1.19 1 1.63 1 1.188 1 43 0 2 497.80164 3.61 16.35 994.59599

APEPHVEEDDDDELDSK ARHGDIB rho GDP-dissociation inhibitor 2 [Homo sapiens]

397 NP_001166 2 1 56676393 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.549 1 1.021 1 1.435 1 1.405 1 1.696 1 1.661 1 1.182 1 43 0 2 446.77023 -1.16 8.21 892.53319

APGELEHGLITFSTR MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648 NP_001027019;NP_001027019

10 2 21264359;21264357

N-Term(iTRAQ4plex) 1.41 10 5.7 0.88 10 17.5 1.245 10 12.9 1.368 10 6.8 1.406 10 10.2 1.596 10 13.9 1.137 10 5.1 43 6.83 1 3 1321.7454 1.07 41.7 2642.49277

APGWDPLCWDECR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex); C8(Methylthio); C12(Methylthio)

1.351 1 1.002 1 1.252 1 1.25 1 1.451 1 1.449 1 1.159 1 42 0 2 510.32458 7.8 16.28 1019.64189

APITK TTN titin isoform N2-A [Homo sapiens] 7273 NP_596869 1 6 291045225 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.412 20 4.9 0.996 20 17.7 1.309 20 14.1 1.349 20 5.1 1.507 20 13.6 1.541 20 6.9 1.13 20 2.2 42 3.41 0 2 598.8465 -5.08 48 1196.6917

APLIPMEHCTTR SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 8 1 4507171 N-Term(iTRAQ4plex); C9(Methylthio)

1.445 6 9.1 1.002 6 14.2 1.379 6 17.3 1.333 6 6.4 1.564 6 16.3 1.468 6 4.3 1.119 6 5 42 3.91 0 2 558.83563 2.18 13.15 1116.66301

APLIPMEHCTTR SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 3 1 4507171 N-Term(iTRAQ4plex); M6(Oxidation); C9(Methylthio)

1.468 2 7.5 0.926 2 1.3 1.349 2 5.9 1.456 2 4.6 1.479 2 10.1 1.597 2 8.8 1.097 2 4.2 42 0 3 367.89459 3.01 15.64 1101.66922

APQTGIVDECCFR IGF1 insulin-like growth factor 1 isoform 2 preproprotein [Homo sapiens]

3479 NP_001104754 4 4 163659901 N-Term(iTRAQ4plex); C10(Methylthio); C11(Methylthio)

1.175 2 4.6 0.963 2 6.9 1.138 2 0.4 1.182 2 6.5 1.169 2 2.8 1.214 2 9.7 1.027 2 3.2 42 3.84 1 3 778.96735 1.5 21.33 1556.92856

APSHQQATTAGSPLR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex) 1.203 4 9.5 0.968 4 15.2 1.14 4 17.2 1.299 4 8.8 1.251 4 20.7 1.502 4 11.1 1.157 4 2.8 41 3.38 0 2 569.82239 2.48 14.52 1138.63628

APSTWLTAYVVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 15 1 115298678 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.766 1 0.898 1 1.602 1 1.784 1 1.749 1 1.948 1 1.092 1 41 5.26 1 3 461.2706 3.13 34.83 1381.79724

APSTYGGGLSVSSR KRT16 keratin, type I cytoskeletal 16 [Homo sapiens]

3868 NP_005548 2 1 24430192 N-Term(iTRAQ4plex) 1.344 5 5.3 0.952 5 11.6 1.239 5 8.1 1.301 5 3.8 1.376 5 8 1.485 5 5.2 1.154 5 9.1 41 3.01 0 2 504.25992 -0.04 11.42 1007.51329

APSTYGGGLSVSSSR KRT14 keratin, type I cytoskeletal 14 [Homo sapiens]

3861 NP_000517 2 1 15431310 N-Term(iTRAQ4plex) 1.351 6 6.5 0.928 6 16.6 1.239 6 14.4 1.303 6 2.6 1.358 6 15.3 1.493 6 5.7 1.117 6 3.1 41 2.76 0 2 498.7244 5.58 24.7 996.44151

APTCGLCEVAR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C4(Methylthio); C7(Methylthio)

1.449 2 6.3 1.14 2 5.5 1.476 2 4.1 1.295 2 9.6 1.625 2 2.7 1.425 2 8.2 1.101 2 1.4 41 0 2 495.78918 0.09 10.89 990.57109

APYEWK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 1 1 4503987 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.496 6 8.2 1.071 6 7.7 1.495 6 12.3 1.332 6 6.8 1.674 6 8.4 1.474 6 3 1.111 6 3.8 40 3 0 2 524.815 -1.32 13.24 1048.6248

APYVWSLPSDLLGLLVPGVSK

LOC100653070

PREDICTED: leukocyte immunoglobulin-like receptor subfamily A member 3-like, partial [Homo sapiens]

100653070 XP_003403896 2 2 341914912 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.338 2 10.3 0.818 2 37.2 1.124 2 30 1.375 2 6.7 1.325 2 24.5 1.621 2 11.9 1.179 2 5.2 40 3.27 0 2 631.32629 -8.03 17.19 1261.65959

AQAVVGDLLELHCEALR FCRL5 Fc receptor-like protein 5 isoform 1 precursor [Homo sapiens]

83416 NP_112571 XP_001133405 XP_001134256

2 2 157694526 N-Term(iTRAQ4plex); C13(Methylthio)

1.297 1 0.918 1 1.16 1 1.264 1 1.327 1 1.446 1 1.145 1 40 0 2 492.31406 -3.25 12.89 983.62084

AQAVVGDLLELHCEAPR FCRL5 Fc receptor-like protein 5 isoform 1 precursor [Homo sapiens]

83416 NP_112571 XP_001133405 XP_001134256

2 2 157694526 N-Term(iTRAQ4plex); C13(Methylthio)

1.281 3 2.2 1.043 3 11.7 1.238 3 13.3 1.314 3 0.4 1.379 3 18.5 1.414 3 0.9 1.08 3 0.5 40 2.77 0 2 443.28592 0.8 32.41 885.56456

AQAWGER APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 2 1 4557325 N-Term(iTRAQ4plex) 1.004 2 6.7 0.795 2 18.6 0.845 2 3.4 1.064 2 15.1 0.96 2 0.2 1.208 2 18.8 1.136 2 3.6 39 4.67 0 3 1296.1729 3.37 53.52 2575.33647

AQGFTEDTIVFLPQTDK PTGDS prostaglandin-H2 D-isomerase precursor [Homo sapiens]

5730 NP_000945 8 1 32171249 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.338 3 14.9 1.062 3 1.1 1.351 3 9.9 1.148 3 1.3 1.577 3 1.5 1.328 3 14.6 1.103 3 7.4 38 2.95 0 2 528.81097 -2.23 19.1 1056.61467

AQIINDAFNLASAHK ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.351 9 7 0.971 9 6.8 1.201 9 13.1 1.298 9 2.1 1.359 9 10.7 1.421 9 8.4 1.132 9 4.2 38 2.96 0 2 535.81476 -1.37 39.89 1070.62224

AQIPILR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex) 1.33 1 1.187 1 1.392 1 1.173 1 1.515 1 1.277 1 1.089 1 38 0 2 526.80328 1.33 19.22 1052.59929

AQITGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

1 5 47132549;16933542

N-Term(iTRAQ4plex) 0.862 3 4.6 0.917 3 3.8 0.777 3 2.4 0.847 3 14.3 0.917 3 7 0.954 3 7.7 1.163 3 4.5 38 3.6 0 2 627.35577 -0.15 55.99 1253.70683

AQLGDLPWQVAIK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 32 1 119392081 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.573 2 1.9 0.998 2 2.1 1.494 2 0.4 1.496 2 1.7 1.649 2 5.3 1.651 2 3.2 1.104 2 4.9 37 0 2 592.35065 -5 35.91 1183.69402

AQLVPLPPSTYVEFTVSGTDCVAK

AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 667 1 156523970 N-Term(iTRAQ4plex); C21(Methylthio); K24(iTRAQ4plex)

1.419 1 1.18 1 1.456 1 1.234 1 1.637 1 1.388 1 1.124 1 36 3.39 0 2 586.29547 -0.48 23.95 1171.58367

AQLYIDCEK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 20 1 40317626 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

0.858 1 1.394 1 0.431 1 0.309 1 1.623 1 1.165 1 3.771 1 36 6.43 1 4 918.2356 2.43 68.38 3669.92055

AQNLYQELLTQEGQASFQGLK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 16 1 105990532 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.207 5 1.4 0.951 5 7.7 1.093 5 1.9 1.229 5 4.1 1.291 5 8.9 1.347 5 2.9 1.127 5 3.8 36 0 2 627.35577 -0.15 55.99 1269.70049

AQNLYQELLTQEGQASFQGLKDNVFDGLVR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

0.895 1 0.815 1 0.742 1 0.911 1 0.882 1 1.082 1 1.188 1 36 5.03 1 3 898.85681 2.81 60.29 2694.55588

AQQELEEQTR MSN moesin [Homo sapiens] 4478 NP_002435 2 1 4505257 N-Term(iTRAQ4plex) 1.329 2 3.2 0.991 2 16.4 1.261 2 10.3 1.272 2 6 1.389 2 12.2 1.401 2 4.1 1.102 2 2 36 3.17 0 2 494.79761 -2.9 18.3 988.58794AQTTVTCMENGWSPTPR CFH complement factor H isoform a

precursor [Homo sapiens]3075 NP_000177 8 2 62739186 N-Term(iTRAQ4plex);

C7(Methylthio)1.067 1 0.912 1 0.953 1 1.046 1 1.086 1 1.191 1 1.139 1 36 4.06 1 3 459.27612 -0.71 16.24 1375.81382

AQTTVTCMENGWSPTPR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 6 2 62739186 N-Term(iTRAQ4plex); C7(Methylthio); M8(Oxidation)

1.226 2 3.5 0.964 2 22.1 1.13 2 15.9 1.173 2 6.1 1.282 2 13 1.331 2 8.9 1.134 2 2.8 35 0 2 459.81805 6.73 16.44 918.62883

AQTTVTCTEK CFHR3 complement factor H-related protein 3 isoform 2 precursor [Homo sapiens]

10878 NP_001160096 6 2 262231791 N-Term(iTRAQ4plex); C7(Methylthio); K10(iTRAQ4plex)

1.287 2 2 0.86 2 33.9 1.092 2 11.2 1.271 2 22 1.316 2 14.9 1.531 2 18.3 1.205 2 3.6 34 3.01 0 2 523.82697 1.74 14.87 1046.64665

AQVSPTASDMLHMR PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 8 1 70780384 N-Term(iTRAQ4plex) 0.934 3 6.5 1.128 3 15.7 1.03 3 37.4 0.997 3 23.4 1.076 3 40.8 1.236 3 1.6 1.073 3 3.9 34 2.78 0 2 557.79419 -2.5 16.89 1114.5811

AQVSPTASDMLHMR PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 2 1 70780384 N-Term(iTRAQ4plex); M10(Oxidation)

0.454 1 0.957 1 0.421 1 0.44 1 0.467 1 0.488 1 1.108 1 34 0 2 627.82214 8.03 27.74 1238.63225

AQWANPFDPSK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 9 1 205277441 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.147 6 3.4 0.962 6 9.2 1.077 6 12.5 1.147 6 12.9 1.153 6 9.2 1.236 6 6 1.132 6 3.4 33 3.01 0 2 512.77063 -2.62 36.67 1024.53276

AQWANPFDPSKTEDSSSFLIDK

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 3 1 205277441 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K22(iTRAQ4plex)

1.648 2 10.4 0.952 2 27.7 1.522 2 25.6 1.598 2 1.9 1.709 2 22.5 1.795 2 4.9 1.123 2 3 33 0 2 491.79095 -6.66 15.58 982.57463

AQYEDIAQK KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 4 1 119395750 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.954 1 1.477 1 1.045 1 0.707 1 1.319 1 0.893 1 1.263 1 33 0 3 435.93964 4.82 20.82 1305.80436

AQYEEIANR KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 2 1 119395754 N-Term(iTRAQ4plex) 1.649 9 7.8 0.974 9 17.8 1.561 9 11.6 1.602 9 7.7 1.695 9 13.3 1.708 9 7.8 1.098 9 5.2 33 0 2 590.28571 1.09 12.27 1179.56413

AQYEEIAQR KRT6A;KRT2

keratin, type II cytoskeletal 6A [Homo sapiens];keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3853;3849 NP_005545 NP_490596;NP_000414

6 7 5031839;47132620

N-Term(iTRAQ4plex) 1.356 1 0.907 1 1.237 1 1.365 1 1.349 1 1.488 1 1.09 1 33 0 2 461.28442 0.87 9.95 921.56157

AQYVLISPEASSR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 8 1 29171717 N-Term(iTRAQ4plex) 0.922 1 0.77 1 0.748 1 0.972 1 0.884 1 1.148 1 1.182 1 33 0 2 541.33282 8.13 16.89 1081.65837

AREDIFMETLK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 15 1 4502337 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.404 2 11.7 0.999 2 7 1.291 2 18 1.292 2 10.9 1.517 2 12.8 1.518 2 5.8 1.175 2 5.1 32 0 2 455.29993 -9.46 26.54 909.59795

AREDIFMETLK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 1 1 4502337 N-Term(iTRAQ4plex); M7(Oxidation); K11(iTRAQ4plex)

1.561 4 5.6 1.031 4 11.8 1.511 4 11.3 1.446 4 2.1 1.662 4 11.9 1.613 4 0.2 1.114 4 2 32 0 2 448.26187 0.37 13.76 895.51647

ASAGLLGAHAAAITAYALTLTK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

191 6 178557739;67190748

N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.717 1 0.965 1 1.563 1 1.619 1 1.813 1 1.878 1 1.16 1 31 0 2 674.3147 -0.5 33.01 1347.62212

ASASDGSSFVVAR GLIPR2 Golgi-associated plant pathogenesis-related protein 1 [Homo sapiens]

152007 NP_071738 2 1 11641247 N-Term(iTRAQ4plex) 1.394 1 1.148 1 1.397 1 1.217 1 1.597 1 1.391 1 1.143 1 31 0 2 461.28442 0.87 7.8 921.56157

ASCYDGR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 3 1 145275213 N-Term(iTRAQ4plex); C3(Methylthio)

1.27 1 0.764 1 0.967 1 1.266 1 1.273 1 1.667 1 1.317 1 31 0 3 381.88562 2.77 18.49 1143.64231

ASEFLGYWEPR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 1.331 9 4.6 0.967 9 5.8 1.247 9 9.6 1.26 9 5.1 1.401 9 6.1 1.418 9 7.3 1.109 9 5.2 31 0 2 477.81473 0.5 33.41 954.62328

ASGDPYWAYSGAYGPEHWVTSSVSCGGR

PTPRG receptor-type tyrosine-protein phosphatase gamma [Homo sapiens]

5793 NP_002832 2 1 194097398 N-Term(iTRAQ4plex); C25(Methylthio)

1.275 1 0.831 1 1.084 1 1.304 1 1.251 1 1.505 1 1.154 1 31 2.76 0 2 443.7869 8.36 25.5 886.56651

ASGSLPYTQTLQDHLNSLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 30 1 105990532 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

2.48 3 264.7 0.747 2 27.6 2.037 3 83339.4 9.395 2 911 0.924 3 300.3 1.26 2 201.5 1.309 3 3714125277 31 5.67 0 4 932.9967 2.56 75.08 3728.97548

ASHEEVEGLVEK LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 2 1 5031863 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.88 1 1.07 1 1.833 1 1.712 1 2.06 1 1.924 1 1.124 1 30 0 2 512.77063 -2.62 36.67 1040.54009

ASIESTSSYTLLIVGNVNRFDSGK

TTN titin isoform N2-A [Homo sapiens] 7273 NP_596869 1 5 291045225 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.865 4 19.4 3.731 4 203.8 3.467 4 411.4 1.381 4 39.9 4.487 4 122.7 1.203 4 33.1 0.952 4 47.9 7.14 0 5 954.48553 1.35 52.27 4768.39857

ASLENSLEETK KRT16;KRT14

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens]

3868;3861 NP_005548;NP_000517

2 2 24430192;15431310

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.123 1 1.219 1 1.17 1 0.96 1 1.323 1 1.085 1 1.13 1 5 0 4 1410.7355 0.1 57.49 2804.47841

ASLINNAFQLVSIGK ERAP1 endoplasmic reticulum aminopeptidase 1 isoform b precursor [Homo sapiens]

51752 NP_001035548 2 2 94818891 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.682 2 5.5 0.77 2 19.1 0.522 2 13.9 0.678 2 33.7 0.681 2 15.6 0.885 2 3.5 1.306 2 29.9 5 0 5 954.48553 1.35 52.27 4752.40125

ASLLTMAFLNGALDGVILGDYLSR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 4 1 156616294 N-Term(iTRAQ4plex); M6(Oxidation)

1.424 1 0.849 1 1.158 1 1.363 1 1.475 1 1.737 1 1.274 1 4.89 1 3 690.03833 0.8 26.67 2068.10044

ASLLTMAFLNGALDGVILGDYLSR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 5 1 156616294 N-Term(iTRAQ4plex) 1.013 1 0.834 1 0.836 1 1.003 1 1.021 1 1.225 1 1.221 1 4.37 0 3 881.11816 -3.44 80.98 2625.34879

ASLVPMEHCITR SPARCL1 SPARC-like protein 1 precursor [Homo sapiens]

8404 NP_001121782 2 1 190194423 N-Term(iTRAQ4plex); C9(Methylthio)

1.389 4 11.3 1.057 4 8.3 1.329 4 4.2 1.286 4 15.7 1.498 4 8.5 1.449 4 16.1 1.116 4 1.7 4.27 0 2 849.98535 3.77 22.49 1698.96343

ASLVPMEHCITR SPARCL1 SPARC-like protein 1 precursor [Homo sapiens]

8404 NP_001121782 1 1 190194423 N-Term(iTRAQ4plex); M6(Oxidation); C9(Methylthio)

1.236 2 13.9 1.1 2 18.9 1.151 2 5.6 1.046 2 24.7 1.45 2 2.8 1.318 2 21.8 1.26 2 2.8 4.25 0 4 574.77869 -16.37 25.86 2296.09292

ASPEKDSLGNSK HOXA10 homeobox protein Hox-A10 [Homo sapiens]

3206 NP_061824 1 1 182765442 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K12(iTRAQ4plex)

0.872 2 12.7 0.929 2 1.9 0.746 2 18.1 0.803 2 20 0.934 2 6.9 1.006 2 8.8 1.252 2 11.1 4.08 1 3 569.34747 4.4 46.25 1706.02787

ASSEGGTAAGAGLDSLHK ARPC1B actin-related protein 2/3 complex subunit 1B [Homo sapiens]

10095 NP_005711 1 1 5031601 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.448 3 0.8 1.035 3 3.6 1.394 3 3.7 1.346 3 0.2 1.554 3 1.6 1.481 3 0.2 1.106 3 0.9 2.85 0 2 503.29623 0.21 31.29 1005.58519

ASSFLGEK C4B complement C4-B preproprotein [Homo sapiens]

721 NP_001002029 NP_000583 XP_001722858

6 2 178557739 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.414 1 1.073 1 1.364 1 1.272 1 1.567 1 1.461 1 1.149 1 2.83 0 2 558.82312 8.78 17.36 1116.63896

ASSIIDELFQDR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 94 1 355594753 N-Term(iTRAQ4plex) 1.26 2 3.8 1.048 2 3.7 1.206 2 9.3 1.151 2 5.6 1.374 2 2.6 1.311 2 1.1 1.139 2 6.7 2.8 0 2 523.82526 -1.54 13.89 1046.64324

ASSLLPESTSRRSGPSDGPTAPYQPR

PRRT4 proline-rich transmembrane protein 4 isoform 2 precursor [Homo sapiens]

401399 NP_001108198 1 2 292658791 N-Term(iTRAQ4plex) 1.543 6 11.7 1.022 6 9.7 1.494 6 6.5 1.454 6 10.3 1.637 6 8.2 1.536 6 10.3 1.079 6 6.5 98 5.47 0 2 802.48572 -1.28 52.22 1603.96245

ASSQWVVGPSYFVEYLIK FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 25 1 58331240 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

2.064 3 4.9 1.094 3 4.6 1.975 3 4.8 1.864 3 10.7 2.261 3 1.4 2.086 3 14.1 1.141 3 0.5 92 5.17 0 2 964.96155 -1.67 26.25 1928.91582

ASVDSGSSEEQGGSSR PIGR polymeric immunoglobulin receptor precursor [Homo sapiens]

5284 NP_002635 4 1 31377806 N-Term(iTRAQ4plex) 1.776 4 6.5 0.924 4 8 1.554 4 1.8 1.717 4 10 1.831 4 3.6 2.024 4 8.2 1.168 4 0.5 89 7.27 0 4 1027.0288 1.09 28.55 2053.05092

ASVGQDSPEPR PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex) 1.697 2 13.4 0.935 2 4.1 1.597 2 7.8 1.707 2 12 1.686 2 14.7 1.803 2 18.9 1.056 2 6.8 81 5.58 0 2 920.50763 -0.33 35.44 1840.00798

ASVSVTAEDEGTQR ICAM1 intercellular adhesion molecule 1 precursor [Homo sapiens]

3383 NP_000192 21 1 167466198 N-Term(iTRAQ4plex) 0.897 1 1.029 1 0.875 1 0.85 1 0.945 1 0.918 1 1.081 1 79 5.54 0 2 893.91766 -0.32 30.87 1786.82805

Page 4: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

ASYAQQPAESR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex) 1.315 1 1.09 1 1.113 1 1.021 1 1.636 1 1.501 1 1.47 1 65 2.8 0 2 983.53229 -0.98 54.48 1966.0573

ASYPDITGEK CETP cholesteryl ester transfer protein precursor [Homo sapiens]

1071 NP_000069 2 1 169636439 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.756 1 1.12 1 1.77 1 1.581 1 1.952 1 1.742 1 1.102 1 63 5.02 0 2 774.92639 -10.94 21.21 1548.84551

ATAQMLEVMFK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 13 1 31652249 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.575 6 9.8 1.006 6 10 1.472 6 18.1 1.573 6 5.8 1.626 6 14.1 1.771 6 6.2 1.125 6 3.3 62 5.11 0 2 785.4118 0.75 28.79 1569.81633

ATAQMLEVMFK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 3 1 31652249 N-Term(iTRAQ4plex); M9(Oxidation); K11(iTRAQ4plex)

2.479 3 5.4 1.055 3 0.2 2.356 3 15.3 2.401 3 10.8 2.555 3 0.5 2.877 3 14.5 1.089 3 0.6 61 3.45 0 3 441.60654 9.68 34.2 1322.80506

ATAVVDGAFK PRDX2 peroxiredoxin-2 isoform a [Homo sapiens]

7001 NP_005800 2 2 32189392 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.703 2 3.6 0.987 2 0.5 1.598 2 1.1 1.619 2 1.6 1.785 2 5.4 1.808 2 5.9 1.117 2 4.3 61 3.33 0 2 776.43079 2.2 28.37 1551.8543

ATFGCHDGYSLDGPEEIECTK

APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 211 1 153266841 N-Term(iTRAQ4plex); C5(Methylthio); C19(Methylthio); K21(iTRAQ4plex)

1.563 3 18.1 0.789 3 26.3 1.225 3 60.6 1.304 3 30.8 1.644 3 0.6 2.074 3 11.3 1.474 3 43.2 57 8.28 0 3 987.90167 1.05 70.76 2961.69046

ATFQTPDFIVPLTDLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 50 1 105990532 N-Term(iTRAQ4plex) 1.776 2 14.3 0.929 2 13.8 1.613 2 22.2 1.735 2 8.3 1.817 2 20.1 1.955 2 6.2 1.127 2 2 56 4.48 0 2 749.87445 -2.08 52.9 1498.7415

ATGVLYDYVNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 45 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.681 1 1.095 1 1.693 1 1.546 1 1.829 1 1.671 1 1.081 1 56 4.05 0 2 640.35809 -0.57 9.94 1279.70891

ATISHVSPDSLYLFR PTPRG receptor-type tyrosine-protein phosphatase gamma [Homo sapiens]

5793 NP_002832 3 1 194097398 N-Term(iTRAQ4plex) 1.397 5 22.1 1.053 5 3.1 1.294 5 18.6 1.204 5 32.2 1.379 5 19.9 1.425 5 29.8 1.204 5 8.5 55 6.12 0 3 971.0484 -0.48 46.03 1941.09354

ATITGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

3 5 47132549;16933542

N-Term(iTRAQ4plex) 1.309 2 48.2 0.893 2 6.4 1.197 2 50.6 1.34 2 43.2 1.281 2 52.9 1.434 2 45.3 1.07 2 1.9 54 3.74 0 2 613.86371 -1.98 27.14 1226.72014

ATLDVDEAGTEAAAATSFAIK

SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 12 1 21361302 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.396 1 0.922 1 1.281 1 1.389 1 1.402 1 1.521 1 1.095 1 54 5.1 1 3 739.70581 -3.66 18.93 2217.10288

ATLDVDEAGTEAAAATSFAIKFFSAQTNR

SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 2 1 21361302 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.527 3 2.3 1.011 3 5.3 1.428 3 10.3 1.53 3 11.8 1.594 3 6.6 1.75 3 15.5 1.116 3 0.2 53 4.81 0 2 723.43201 -2.72 46.78 1445.85747

ATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); M10(Oxidation); K41(iTRAQ4plex)

1.582 2 13.6 0.909 2 7.1 1.427 2 10.5 1.57 2 17.7 1.594 2 9.8 1.754 2 17.1 1.117 2 0.6 51 4.29 0 2 644.3551 0.29 21.21 1287.70293

ATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K41(iTRAQ4plex)

1.659 2 6.6 1.049 2 1.5 1.593 2 4.9 1.518 2 3.4 1.807 2 9.6 1.722 2 8 1.134 2 4.7 50 4.1 0 2 674.3233 7.11 26.94 1347.63933

ATLGPAVRPLPWQR CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 6 1 42544239 N-Term(iTRAQ4plex) 1.373 2 55.9 1.078 2 19 1.41 2 44.7 1.307 2 67.8 1.449 2 44.1 1.344 2 67.1 1.028 2 0.5 48 0 2 631.84546 -2.73 18.8 1262.68364

ATLLDIYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 34 2 38016947 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.576 1 0.894 1 1.35 1 1.509 1 1.635 1 1.828 1 1.211 1 46 0 2 546.26715 -0.2 18.17 1091.52703

ATLSEK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 6 1 156523970 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.713 3 6.3 0.77 3 49.1 1.259 3 29.7 1.443 3 10.5 1.749 3 19.7 2.272 3 27.5 1.218 3 11 42 4.17 0 3 588.35132 -1.12 81.61 1763.0394

ATLYALSHAVNNYHK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.577 2 2.4 0.94 2 7.9 1.433 2 3.1 1.523 2 4.8 1.628 2 0.1 1.731 2 8 1.136 2 3.2 41 4.2 0 2 836.88678 -0.16 57.1 1672.76396

ATMDAGKLVSDEMVVELIEKNLETPLCK

AK2 adenylate kinase 2, mitochondrial isoform c [Homo sapiens]

204 NP_001186128 1 3 312836806 N-Term(iTRAQ4plex); M3(Oxidation); K7(iTRAQ4plex); M13(Oxidation); K20(iTRAQ4plex); C27(Methylthio); K28(iTRAQ4plex)

1.479 3 4.5 1.01 3 1.1 1.418 3 23.9 1.439 3 3.7 1.556 3 12.4 1.794 3 4.6 1.133 3 4.7 41 3.42 0 2 546.26715 -0.2 18.17 1075.53325

ATTVTGTPCQDWAAQEPHR

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 88 1 4505881 N-Term(iTRAQ4plex); C9(Methylthio)

1.62 3 14.5 1.047 3 2.1 1.566 3 16.7 1.496 3 11.8 1.751 3 17.4 1.672 3 12.5 1.118 3 0.7 41 3.57 0 2 666.90869 -2.15 34.66 1332.81011

ATVAVYLESLQDTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.739 1 0.732 1 1.374 1 1.878 1 1.637 1 2.238 1 1.192 1 41 3.4 0 2 699.92664 0.93 50.44 1398.84599

ATVLNYLPK A2M;PZP alpha-2-macroglobulin precursor [Homo sapiens];pregnancy zone protein precursor [Homo sapiens]

2;5858 NP_000005;NP_002855

19 2 66932947;162809334

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.336 1 0.953 1 1.287 1 1.35 1 1.322 1 1.387 1 1.028 1 41 4.61 0 2 843.93628 -4.58 27.26 1686.86528

ATVNPSAPR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 6 1 4557417 N-Term(iTRAQ4plex) 1.346 1 1.178 1 1.411 1 1.197 1 1.522 1 1.291 1 1.078 1 37 2.9 0 2 707.83258 -0.46 18.43 1414.65788

ATVVYQGER APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 38 1 153266841 N-Term(iTRAQ4plex) 1.942 2 1.5 1.114 2 5.9 1.961 2 4.9 1.76 2 1 2.144 2 1.4 1.924 2 7.3 1.093 2 6.3 35 2.81 0 2 632.32965 1.63 20.24 1263.65203

ATWSGAVLAGR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 95 1 21071030 N-Term(iTRAQ4plex) 1.436 1 0.785 1 1.209 1 1.542 1 1.354 1 1.725 1 1.119 1 35 4.23 0 3 555.9649 0.72 11.3 1665.88016

ATYFGSIVLLSPAVIDSPLK PLTP phospholipid transfer protein isoform c precursor [Homo sapiens]

5360 NP_001229849 4 4 339275807 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

0.542 1 1.074 1 0.541 1 0.504 1 0.583 1 0.543 1 1.077 1 23 0 2 619.27545 1.13 13.73 1237.54363

AVAEPGIQLK THBS4;COMP

thrombospondin-4 precursor [Homo sapiens];cartilage oligomeric matrix protein precursor [Homo sapiens]

7060;1311 NP_003239;NP_000086

2 2 31543806;40217843

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.357 1 0.959 1 2.22 1 2.314 1 2.399 1 2.501 1 1.081 1 5.46 0 3 665.71625 -3.86 40.54 1995.13419

AVAGNISDPGLQK VCL vinculin isoform VCL [Homo sapiens]

7414 NP_003364 2 2 4507877 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.629 1 1.044 1 1.568 1 1.502 1 1.761 1 1.688 1 1.123 1 3.32 0 2 642.80963 -3.41 22.06 1284.61199

AVASFLR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 2 2 126273569 N-Term(iTRAQ4plex) 0.916 1 1.074 1 0.868 1 0.809 1 1.03 1 0.96 1 1.187 1 39 4.08 0 3 675.67188 2.78 68.04 2025.00107

AVDAALK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

17 3 4504893;156231037

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.783 1 1.014 1 0.745 1 0.735 1 0.832 1 0.821 1 1.117 1 3.17 0 2 620.80017 -0.36 40.84 1240.59307

AVDQSVLLMKPDAELSASSVYNLLPEK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); M9(Oxidation); K10(iTRAQ4plex); K27(iTRAQ4plex)

1.012 2 7.2 0.97 2 11.1 0.948 2 1.4 0.976 2 12.5 1.047 2 1.9 1.079 2 13.1 1.105 2 0.5 51 3.78 0 2 633.86884 11.96 33.72 1266.73039

AVDQSVLLMKPDAELSASSVYNLLPEK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 8 1 66932947 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K27(iTRAQ4plex)

2.565 1 1.021 1 2.461 1 2.411 1 2.722 1 2.666 1 1.106 1 45 4.63 0 2 700.82458 -0.02 38.25 1400.64189

AVDQSVLLMKPEAELSVSSVYNLLTVK

PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 12 1 162809334 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K27(iTRAQ4plex)

1.776 1 0.71 1 1.399 1 1.971 1 1.637 1 2.307 1 1.17 1 34 0 2 532.77649 -5.11 34.82 1064.5457

AVDQSVLLMKPEAELSVSSVYNLLTVK

PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 1 1 162809334 N-Term(iTRAQ4plex); M9(Oxidation); K10(iTRAQ4plex); K27(iTRAQ4plex)

1.318 1 0.906 1 1.132 1 1.25 1 1.38 1 1.524 1 1.22 1 3.45 2 3 929.52722 18.63 32.84 2786.56711

AVDTWSWGER LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 3 1 5031863 N-Term(iTRAQ4plex) 1.505 1 0.902 1 1.296 1 1.437 1 1.566 1 1.737 1 1.209 1 55 6.49 0 3 621.33484 0.56 19.8 1861.98996

AVGDKLPECEADDGCPKPPEIAHGYVEHSVR

HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 9 1 4826762 N-Term(iTRAQ4plex); K5(iTRAQ4plex); C9(Methylthio); C15(Methylthio); K17(iTRAQ4plex)

1.134 1 0.759 1 0.94 1 1.237 1 1.055 1 1.389 1 1.123 1 39 3.5 0 2 643.88202 1.44 37.25 1286.75676

AVGDKLPECEAVCGKPK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 2 3 4826762 N-Term(iTRAQ4plex); K5(iTRAQ4plex); C9(Methylthio); C13(Methylthio); K15(iTRAQ4plex); K17(iTRAQ4plex)

1.334 1 0.848 1 1.121 1 1.323 1 1.344 1 1.586 1 1.199 1 30 0 3 651.65723 -4.12 15.43 1952.95713

AVGLAGTFR COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 1 2 110611233 N-Term(iTRAQ4plex) 0.959 1 0.967 1 0.876 1 0.906 1 1.01 1 1.045 1 1.153 1 27 3.85 0 2 731.3324 -0.54 18.65 1461.65752

AVGSGATFSHYYYMILSR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

284 6 178557739;67190748

N-Term(iTRAQ4plex) 0.997 2 3.1 0.843 2 0.4 0.846 2 9.6 1.003 2 10 0.987 2 14.3 1.171 2 13.9 1.167 2 24.2 76 3.97 0 3 404.57806 -2.67 20.38 1211.71964

AVGSGATFSHYYYMILSR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

26 6 178557739;67190748

N-Term(iTRAQ4plex); M14(Oxidation)

1.125 1 1.058 1 1.134 1 1.071 1 1.183 1 1.118 1 1.044 1 62 6.08 0 3 692.71356 -2.59 47.36 2076.12613

AVGYLITGYQR PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex) 0.92 2 27.5 1.182 2 14.6 0.957 2 16.6 0.81 2 31.8 1.053 2 21.9 0.89 2 37.3 1.099 2 5.1 57 4.28 0 2 685.38684 7.18 17.23 1369.73613

AVISPGFDVFAK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 26 3 14550407 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.049 1 0.974 1 0.992 1 1.018 1 1.079 1 1.108 1 1.089 1 30 2.81 0 2 592.31329 0.42 20.74 1183.61931

AVLDVFEEGTEASAATAVK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 492 1 50659080 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.012 1 0.952 1 0.942 1 0.989 1 1.034 1 1.087 1 1.099 1 2.98 0 2 666.37286 -1.15 36.42 1331.73845

AVLDVFEEGTEASAATAVKITLLSALVETR

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 2 1 50659080 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.517 1 1.405 1 1.243 1 0.884 1 3.8 1 4 862.9248 -9.33 38.43 3448.67739

AVLHIGEK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 1 1 205277441 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.416 1 0.769 1 0.91 1 1.184 1 1.594 1 2.074 1 1.751 1 4 2 4 862.9306 10.27 39.11 3448.70058

AVLPQEEEGSGGGQLVTEVTK

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 2 1 4502067 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

0.904 2 5 0.943 2 20.8 0.796 2 22.3 0.844 2 1.4 0.963 2 9.2 1.022 2 11.4 1.211 2 12.9 45 3.1 0 2 582.81927 -3.26 10.51 1164.6364

AVLQLNEEGVDTAGSTGVTLNLTSKPIILR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 6 1 73858564 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

0.703 3 2.1 0.747 3 12.5 0.571 3 1.6 0.764 3 4.7 0.658 3 12.4 0.88 3 0 1.151 3 0.6 40 0 2 472.29868 9.08 12.88 943.59007

AVLTIDEK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 2 1 189163538 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.227 1 0.936 1 1.184 1 1.266 1 1.191 1 1.273 1 1.006 1 115 5.97 0 2 873.95667 -2.45 33.06 1746.90605

AVLYNYR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex) 1.345 1 0.904 1 1.19 1 1.317 1 1.371 1 1.517 1 1.152 1 51 4.33 0 2 730.83002 -0.29 39.06 1460.65276

AVPHPDSQPDTIDHDLLLLQLSEK

CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 3 1 42544239 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.418 2 8.5 0.776 2 5.6 1.119 2 17.1 1.442 2 11.5 1.398 2 6 1.802 2 0.4 1.25 2 11 51 7.58 0 4 964.51642 5.67 61.47 2891.52089

AVPPNNSNAAEDDLPTVELQGVVPR

F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 2 1 119395709 N-Term(iTRAQ4plex) 1.213 2 22.8 0.938 2 5.5 1.114 2 18 1.188 2 12.4 1.235 2 32.6 1.317 2 26.7 1.109 2 13.9 46 6.89 0 3 765.74878 -3.62 49.08 2295.2327

AVSISPTNVILTWK PTPRJ receptor-type tyrosine-protein phosphatase eta isoform 2 precursor [Homo sapiens]

5795 NP_001091973 2 2 148728160 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.996 1 0.991 1 0.954 1 0.963 1 1.03 1 1.039 1 1.079 1 40 0 2 551.31 -5.06 28.35 1101.61272

AVSMPSFSILGSDVR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 36 1 105990532 N-Term(iTRAQ4plex); M4(Oxidation)

1.229 1 0.928 1 1.1 1 1.185 1 1.269 1 1.368 1 1.154 1 34 4.18 0 2 739.33301 1.02 48 1477.65874

AVSMPSFSILGSDVR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex) 1.227 2 5.1 0.884 2 5.6 1.081 2 8.4 1.223 2 2.9 1.23 2 7.1 1.392 2 1.5 1.138 2 1.3 3.44 0 2 625.86536 0.72 50.55 1250.72344

AVSPLPYLR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 1 1 89191868 N-Term(iTRAQ4plex) 1.043 1 0.964 1 0.948 1 0.983 1 1.1 1 1.141 1 1.16 1 2.93 0 2 518.31128 8.2 34.71 1035.61528

AVSPPAR CRISP3 cysteine-rich secretory protein 3 isoform 1 precursor [Homo sapiens]

10321 NP_006052 1 2 300244560 N-Term(iTRAQ4plex) 1.209 7 13.7 1.045 7 11 1.195 7 18.2 1.051 7 8.4 1.177 7 25.8 1.179 7 7.3 1.113 7 1.1 105 5.66 0 2 972.95319 -4.28 26.48 1944.8991

AVVEVDESGTR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 8 1 194018472 N-Term(iTRAQ4plex) 1.151 8 8.5 1.076 8 15 1.121 8 18.8 1.111 8 13.9 1.261 8 6.9 1.159 8 7.5 1.135 8 5 99 5.45 0 3 1078.4805 0.59 40.35 2155.95682

AVVFLEPQWYR FCGR3A low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor [Homo sapiens]

2214 NP_001121068 4 4 189083842 N-Term(iTRAQ4plex) 1.232 4 10.5 0.951 4 12 1.121 4 15.4 1.22 4 17.1 1.313 4 23.1 1.42 4 16.3 1.171 4 7.5 96 7.04 0 2 1084.9711 0.13 34.57 2168.93389

AVVFLEPQWYSVLEK FCGR3B low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor [Homo sapiens]

2215 NP_000561 4 2 132814489 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.266 2 18.6 0.817 2 33.2 1.158 2 14.5 1.418 2 49.4 1.149 2 6.8 1.407 2 26 0.993 2 21.4 89 8.09 0 4 727.12146 0.15 46.44 2905.46401

AVVHGILMGVPVPFPIPEPDGCK

NPC2 epididymal secretory protein E1 precursor [Homo sapiens]

10577 NP_006423 2 1 5453678 N-Term(iTRAQ4plex); M8(Oxidation); C22(Methylthio); K23(iTRAQ4plex)

1.049 2 13.7 0.976 2 11.5 0.957 2 8 0.981 2 19.6 1.118 2 8 1.145 2 19.6 1.168 2 0 80 6.14 0 2 1205.6011 3.53 50.55 2410.19748

AVVVHAGEDDLGR SOD3 extracellular superoxide dismutase [Cu-Zn] precursor [Homo sapiens]

6649 NP_003093 4 1 118582275 N-Term(iTRAQ4plex) 1.221 8 8.6 0.932 8 13.6 1.121 8 3.9 1.222 8 13.3 1.237 8 10.1 1.322 8 10.9 1.114 8 13.4 79 5.46 0 2 846.95917 3.23 44.44 1692.91106

AVYLPNCDR IGFBP5 insulin-like growth factor-binding protein 5 precursor [Homo sapiens]

3488 NP_000590 1 1 10834982 N-Term(iTRAQ4plex); C7(Methylthio)

1.141 8 1.4 0.911 8 6.6 1.04 8 5.7 1.141 8 11.5 1.178 8 11 1.278 8 9.8 1.171 8 7.7 78 5.9 0 2 957.00934 -1.21 57.67 1913.02068

AVYTCNEGYQLLGEINYR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 226 2 62739186 N-Term(iTRAQ4plex); C5(Methylthio)

1.148 8 11 0.895 8 29.6 1.081 8 18.8 1.099 8 7.8 1.143 8 21.7 1.26 8 9 1.134 8 2.8 75 4.19 0 2 742.90155 -4.68 34.58 1484.80058

AWAYYSAVNPEK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.207 1 0.832 1 0.994 1 1.195 1 1.217 1 1.463 1 1.224 1 73 3.25 0 2 1188.0006 1.94 46.44 2374.99394

AWEDTLDK ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 2 2 221316614 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.406 2 3.4 0.837 2 22.4 1.148 2 18.1 1.371 2 4.2 1.442 2 10 1.722 2 12.3 1.256 2 8 72 8.77 0 3 787.39227 0.2 32.31 2360.16227

AWFLESK APOC4 apolipoprotein C-IV precursor [Homo sapiens]

346 NP_001637 4 1 4502161 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.172 12 7.8 0.954 10 28.3 1.014 12 20.8 1.169 10 13.1 1.241 12 18 1.402 10 15.6 1.163 12 6.8 72 8.78 1 3 988.4516 5.25 77.47 2963.34024

AWQDCGMR FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 2 1 58331240 N-Term(iTRAQ4plex); C5(Methylthio)

0.92 4 8.2 0.939 4 10.5 0.897 4 4.1 0.892 4 11.2 0.942 4 10.2 1.006 4 4.5 1.096 4 4.9 71 4.1 0 2 761.89502 -1.76 40.54 1522.78166

AWRPALYLAALDCAEETNSAVCR

QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

8 2 13325075 N-Term(iTRAQ4plex); C13(Methylthio); C22(Methylthio)

1.418 1 1.23 1 1.529 1 1.243 1 1.632 1 1.327 1 1.068 1 69 5.1 0 2 1059.543 -7.04 24.35 2118.07866

AYIFIDEAHITQALIWLSQR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 11 1 66932947 N-Term(iTRAQ4plex) 1.059 2 1 0.821 2 10.1 0.852 2 0.8 1.038 2 10.9 1.076 2 10.7 1.311 2 0.6 1.263 2 11.5 66 5.3 0 3 927.44122 -0.19 22.62 1853.87583

AYISMHSYSQHIVFPYSYTR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 1 2 126273569 N-Term(iTRAQ4plex) 1.013 2 5.7 0.849 2 10.2 0.845 2 5.3 0.996 2 4.8 1.029 2 14.5 1.212 2 4.3 1.217 2 9.1 64 4.28 0 2 690.8681 -0.2 26.1 1380.72893

AYLEEECPATLR AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 47 1 4502337 N-Term(iTRAQ4plex); C7(Methylthio)

1.053 7 9.6 0.954 7 13.4 0.965 7 10.9 1.085 7 2.9 1.116 7 7.9 1.185 7 6.2 1.119 7 4.8 61 3.92 0 3 748.91187 -2.9 25.03 1496.82227

AYSDLSR APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 4 1 4502133 N-Term(iTRAQ4plex) 1.158 2 3.3 0.965 2 15 1.099 2 1.8 1.139 2 13.1 1.18 2 6 1.222 2 8.9 1.073 2 4.1 57 6.86 1 3 1231.6376 0.28 41.8 2462.26865

AYSLFSYNTQGR APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 30 1 4502133 N-Term(iTRAQ4plex) 2.329 2 12.3 0.877 2 8.3 2.054 2 7 2.343 2 15.4 2.318 2 9.7 2.643 2 18.1 1.128 2 2.6 52 3.13 0 2 761.89502 -1.76 40.54 1538.77751

AYYENSPQQVFSTEFEVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 24 1 115298678 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.212 1 0.846 1 1.052 1 1.243 1 1.185 1 1.401 1 1.127 1 44 0 2 523.29407 -10.73 15.99 1045.58086

AYYHLLEQVAPK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 3 1 167614506 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.813 1 0.817 1 0.65 1 0.796 1 0.827 1 1.013 1 1.273 1 41 4.13 1 2 783.91522 -0.81 32.19 1566.82317

CAANMR PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 2 1 156616294 C1(Methylthio); N-Term(iTRAQ4plex)

1.422 1 1.249 1 1.481 1 1.186 1 1.717 1 1.375 1 1.159 1 40 3.25 0 2 690.8681 -0.2 26.1 1396.71404

CADDQPPSILDPPDQVQFEK

MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 4 1 205277383 C1(Methylthio); N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.014 2 13.5 1.013 2 4.9 1.001 2 14 0.988 2 19 1.04 2 8.1 1.027 2 13.1 1.04 2 5.8 36 6.85 0 4 688.33398 1.89 46.87 2750.31411

CAEENCFIQK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 22 1 115298678 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

1.208 1 0.843 1 1.025 1 1.215 1 1.202 1 1.426 1 1.174 1 33 3.54 0 3 417.55893 1.01 10.44 1250.66224

CAGPEAVK LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 8 1 16418467 C1(Methylthio); N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.191 1 1.032 1 1.152 1 1.117 1 1.267 1 1.228 1 1.099 1 14 0 2 421.6756 -0.05 11.52 842.34392

CAGPGAHAGLPLWALPGGDAECPGPR

GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 4 1 4758460 C1(Methylthio); N-Term(iTRAQ4plex); C22(Methylthio)

1.005 1 1.325 1 1.111 1 0.838 1 1.225 1 0.924 1 1.102 1 3.47 0 3 535.63324 -11.68 22.64 1604.88517

CAGQQQDIR CFP properdin precursor [Homo sapiens] 5199 NP_001138724 6 1 223671861 C1(Methylthio); N-Term(iTRAQ4plex)

1.124 2 0.4 0.991 2 7 1.059 2 1.5 1.068 2 8.5 1.179 2 7.1 1.19 2 0.2 1.114 2 8.7 3.33 0 2 632.30219 -0.91 47.71 1263.59709

CAPGYYGNPSQGQPCQR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 C1(Methylthio); N-Term(iTRAQ4plex); C15(Methylthio)

1.237 1 0.954 1 1.157 1 1.212 1 1.26 1 1.32 1 1.089 1 2.86 0 2 570.78601 1.38 13.22 1140.56474

CCDLPFPEQACCAEEEK ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 1 3 221316614 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); C11(Methylthio); C12(Methylthio); K17(iTRAQ4plex)

0.864 1 0.9 1 0.8 1 0.889 1 0.842 1 0.936 1 1.052 1 69 3.01 0 2 750.94952 3.4 63 1500.89177

CCEDGMR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio)

1.822 1 0.911 1 1.598 1 1.754 1 1.885 1 2.069 1 1.18 1 3.7 0 3 622.68164 2.79 40.46 1866.03037

CCEDGMR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); M6(Oxidation)

1.375 3 4.7 0.876 3 2.1 1.19 3 0.6 1.353 3 2.7 1.373 3 17 1.59 3 3.3 1.154 3 12.8 4.25 1 4 720.61835 -13.05 58.16 2879.45156

CCESASEDCMAK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 348 2 32483410 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); C9(Methylthio); K12(iTRAQ4plex)

1.114 1 0.897 1 0.998 1 1.113 1 1.114 1 1.243 1 1.117 1 53 3.85 0 2 607.36334 0.87 35.66 1213.71941

CCESASEDCMAK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 85 2 32483410 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); C9(Methylthio); M10(Oxidation); K12(iTRAQ4plex)

1.012 1 0.723 1 0.782 1 1.082 1 0.962 1 1.331 1 1.23 1 38 3.61 0 2 589.33002 -1.5 32.98 1177.65276

CCHCCLLGR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

2 4 34734066;34734062

C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); C4(Methylthio); C5(Methylthio)

1.148 2 4.6 0.994 2 14 1.067 2 4.2 1.074 2 9.7 1.223 2 0.8 1.231 2 13.2 1.146 2 3.4 38 2.92 0 2 583.35236 0.19 28.95 1165.69695

CCPDYESFCAEVK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 4 2 189181722 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); C9(Methylthio); K13(iTRAQ4plex)

1.326 557 19.6 0.943 549 24.3 1.212 548 26.7 1.278 546 22.7 1.383 556 26.5 1.447 552 22.2 1.134 551 20.2 108 9.4 0 3 1316.1523 -2.07 50.99 2631.29741

CCQDGVTR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

6 6 178557739;67190748

C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio)

1.41 513 12 0.943 513 13.4 1.297 513 15.2 1.372 513 14 1.459 513 14.5 1.558 513 14.2 1.126 513 9.5 103 6.84 0 3 1030.6082 2.71 57.24 2060.20903

CCYDGACVNNDETCEQR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 4 2 38016947 C1(Methylthio); N-Term(iTRAQ4plex); C2(Methylthio); C7(Methylthio); C14(Methylthio)

1.333 689 13.8 0.972 689 23.2 1.235 689 20.5 1.273 689 19.9 1.412 689 19.3 1.443 689 18.2 1.129 689 15.3 103 8.32 0 4 1249.1213 0.68 56.4 2497.23403

CDDWGLDTMR IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 2 3 19882209 C1(Methylthio); N-Term(iTRAQ4plex)

1.232 18 15.2 1.002 18 20.9 1.207 18 14.7 1.16 18 15.2 1.349 18 21.9 1.406 18 23.1 1.195 18 15.3 101 10.41 0 3 1183.5571 0.19 51.6 3548.65683

CDEAQVLQVWDDPYPEVLSQEPFHK

CSF1R macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens]

1436 NP_005202 5 1 27262659 C1(Methylthio); N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.429 156 24.3 0.943 156 29.5 1.268 156 38.4 1.332 156 28.4 1.428 156 37 1.542 156 37.9 1.123 156 26.1 100 10.39 0 3 1169.8998 2.78 48.2 3507.68552

CDEDEDIGRPQVFSEVR IGF2R cation-independent mannose-6-phosphate receptor precursor [Homo sapiens]

3482 NP_000867 1 1 119964726 C1(Methylthio); N-Term(iTRAQ4plex)

1.316 430 8.6 0.962 430 11.1 1.207 430 11.9 1.25 430 10.5 1.372 430 10.7 1.435 430 10.3 1.136 430 8 89 6.77 0 3 923.42505 2.55 66.67 1845.84848

Page 5: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

CDLFQK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 C1(Methylthio); N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.363 5 12.1 0.933 5 3 1.242 5 13.1 1.385 5 7.1 1.41 5 13.4 1.503 5 11.8 1.174 5 16 88 5.15 0 3 513.25073 0.26 31.23 1537.73442

CDPHEATCYDDGK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

18 5 47132549;16933542

C1(Methylthio); N-Term(iTRAQ4plex); C8(Methylthio); K13(iTRAQ4plex)

1.199 4 11.6 0.954 4 6.1 1.157 4 7.7 1.164 4 1.5 1.232 4 19.7 1.276 4 15.3 1.085 4 9.4 83 5.13 0 3 934.979 1.48 55.15 1868.95676

CDPVDQCQDSETGTFYQIGDSWEK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

25 6 47132549;16933542

C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio); K24(iTRAQ4plex)

1.611 112 15.4 0.945 112 15.9 1.464 112 16.4 1.542 112 19.9 1.626 112 13.7 1.736 112 17.8 1.125 112 6.3 82 5.4 0 3 894.94452 -2.92 53.25 1788.8873

CDSSPDSAEDVR AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 23 1 156523970 C1(Methylthio); N-Term(iTRAQ4plex)

1.39 253 7.1 0.94 253 12.7 1.255 253 12.7 1.34 253 9.5 1.439 253 11 1.515 253 9.9 1.134 253 6.3 80 4.9 0 2 715.40112 1.41 21.63 1429.79302

CDSSPDSAEDVRK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 2 1 156523970 C1(Methylthio); N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.8 5 51.6 0.925 5 25.7 1.537 5 40.1 1.401 5 17.2 1.49 5 50.1 1.559 5 35.3 1.07 5 22.1 80 9.15 1 4 1109.6314 0.9 63.93 3326.87758

CEDSER C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 4 1 45580688 C1(Methylthio); N-Term(iTRAQ4plex)

1.298 375 11 1.016 375 18.4 1.229 375 16.6 1.206 375 12.2 1.4 375 16.8 1.386 375 12.1 1.134 375 8.1 76 5.63 0 2 894.94452 -2.92 53.25 1772.8936

CEEDEEFTCR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 69 2 4505881 C1(Methylthio); N-Term(iTRAQ4plex); C9(Methylthio)

1.304 244 11.2 0.944 244 15.8 1.196 244 17.1 1.272 244 14.5 1.342 244 16.5 1.423 244 16.4 1.135 244 12 71 6.95 0 3 1063.5466 -2.35 30.1 2126.08994

CEGFVCAQTGR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 19 1 4557391 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio)

1.688 64 30 0.413 46 94.4 0.959 64 25.7 2.8 45 71.3 1.051 64 38.1 3.293 45 70.2 1.078 64 29.2 69 10 0 4 821.13855 -1.65 45.37 3281.55459

CEGLCPK INSRR insulin receptor-related protein precursor [Homo sapiens]

3645 NP_055030 1 1 31657140 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); K7(iTRAQ4plex)

1.345 201 6 0.96 201 7.2 1.234 201 8.3 1.274 201 6.9 1.377 201 7.8 1.443 201 7.1 1.124 201 3.9 66 4.21 0 2 682.85834 1.04 36.11 1364.70793

CEGPIPDVTFELLR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 98 1 21071030 C1(Methylthio); N-Term(iTRAQ4plex)

1.319 281 7.9 1.054 281 9.1 1.286 281 9.4 1.211 281 5.5 1.452 281 9.3 1.388 281 6.1 1.141 281 4.2 65 4.34 0 2 650.32587 7.29 21.34 1299.63823

CEGSSVQTR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 3 1 40317626 C1(Methylthio); N-Term(iTRAQ4plex)

1.193 101 5.3 0.944 101 5.9 1.102 101 5.5 1.156 101 6.7 1.24 101 6.2 1.295 101 6 1.126 101 4.4 52 4.8 0 3 543.58698 -0.41 38.23 1628.74765

CEIAGWGETK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 6 1 205277383 C1(Methylthio); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.389 7 4.9 0.907 7 15.8 1.272 7 11.4 1.394 7 11.3 1.461 7 13.4 1.635 7 3 1.145 7 5.4 51 6.09 1 3 911.99817 2.6 30.65 1822.97989

CELNCPK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); K7(iTRAQ4plex)

1.35 313 8.3 0.992 313 14.8 1.296 313 11.7 1.283 313 6.5 1.451 313 11.1 1.452 313 7.6 1.131 313 4.3 51 3.36 0 2 653.37524 -1.03 81.32 1305.74321

CENTDPGYNCLPCPPR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 5 1 40317626 C1(Methylthio); N-Term(iTRAQ4plex); C10(Methylthio); C13(Methylthio)

1.181 194 7.1 0.989 194 10.9 1.09 194 10.9 1.113 194 10 1.251 194 10.6 1.274 194 8.8 1.152 194 7.7 49 5.04 1 3 473.29196 3.86 60.93 1417.8584

CEPCDAR IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 1 2 62243068 C1(Methylthio); N-Term(iTRAQ4plex); C4(Methylthio)

1.902 1 1.073 1 2.146 1 1.999 1 1.797 1 1.674 1 0.837 1 44 6.91 1 4 772.39655 -1.28 52.62 3086.56435

CEPIGCDGVLFSTHTLDK ADAMTSL2 ADAMTS-like protein 2 precursor [Homo sapiens]

9719 NP_055509 XP_003403622 XP_003403874 XP 003403875

2 1 41281450 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); K18(iTRAQ4plex)

1.108 5 3.8 0.93 5 1 1.088 5 25.4 1.12 5 19.7 1.226 5 21.6 1.31 5 27.3 1.18 5 2.6 44 3.3 1 2 706.88458 -10.51 17.63 1412.77239

CEQCQPGYYGDAQR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 C1(Methylthio); N-Term(iTRAQ4plex); C4(Methylthio)

1.514 15 22.4 1.062 15 9.8 1.407 15 26 1.406 15 15.1 1.622 15 29.1 1.652 15 12 1.098 15 5.7 44 2.78 0 2 650.32587 7.29 21.34 1315.6364

CEQFCK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 3 1 4503649 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

1.316 1 0.829 1 1.192 1 1.438 1 1.214 1 1.465 1 1.019 1 39 4.1 0 3 477.61642 -0.78 16.96 1430.83472

CEVQDR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 1 1 4502503 C1(Methylthio); N-Term(iTRAQ4plex)

1.253 133 4.5 0.945 133 6.1 1.141 133 6.9 1.214 133 6.3 1.301 133 5.2 1.369 133 6.3 1.134 133 4.4 37 3.6 0 3 425.85126 -3.85 28.74 1275.54424

CEWETPEGCEQVLTGK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 14 1 4502503 C1(Methylthio); N-Term(iTRAQ4plex); C9(Methylthio); K16(iTRAQ4plex)

1.288 161 8.8 0.957 161 19.4 1.192 161 16.9 1.232 161 4.8 1.348 161 15.9 1.412 161 5.6 1.142 161 3.6 37 3.08 0 2 631.38031 -1.1 87.66 1261.75652

CEWETPEGCEQVLTGKR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 4 1 4502503 C1(Methylthio); N-Term(iTRAQ4plex); C9(Methylthio); K16(iTRAQ4plex)

1.389 27 11.2 0.942 27 4.3 1.288 27 17 1.371 27 16.3 1.438 27 11.9 1.549 27 13.4 1.14 27 5.1 37 0 2 425.85126 -3.85 28.74 1291.53838

CEYCDSGYR LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 2 5 261337173 C1(Methylthio); N-Term(iTRAQ4plex); C4(Methylthio)

1.407 136 5.9 1.047 136 6.7 1.364 136 6.6 1.306 136 5.8 1.545 136 7.6 1.481 136 6.7 1.141 136 3.3 34 3.01 0 2 527.30243 0.39 2.14 1053.59587

CFEGFGIDGPAIAK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 95 1 62739186 C1(Methylthio); N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.425 5 3 1.1 5 1.1 1.367 5 1.3 1.293 5 6.3 1.539 5 2.2 1.491 5 9.5 1.124 5 3.7 34 0 2 399.7334 0.58 7 798.46013

CFEPQLLR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 6 1 145275213 C1(Methylthio); N-Term(iTRAQ4plex)

1.354 1 0.966 1 1.255 1 1.3 1 1.406 1 1.456 1 1.12 1 30 0 2 389.22324 2.07 17.24 777.4392

CFESFER PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 2 4 189181722 C1(Methylthio); N-Term(iTRAQ4plex)

1.183 2 1.9 0.808 2 10.6 1.02 2 12.8 1.262 2 2.2 1.12 2 1.1 1.385 2 9.5 1.097 2 11.7 4.45 1 3 584.00079 -1.25 18.47 1749.98783

CFLAFTQTK CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 22 1 156627579 C1(Methylthio); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.858 1 0.933 1 0.781 1 0.837 1 0.878 1 0.94 1 1.123 1 4.02 1 3 554.58569 4.2 26.18 1661.74253

CFLGCELPPEGSR PROCR endothelial protein C receptor precursor [Homo sapiens]

10544 NP_006395 2 1 34335272 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio)

1.006 2 23.3 1.038 2 14.3 1.038 2 33.2 0.999 2 18.2 1.016 2 28.8 0.979 2 14 0.979 2 4.1 89 4.03 0 2 832.39539 2.01 21.31 1663.78349

CFSGQCISK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 14 1 45580688 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

0.705 1 0.704 1 0.53 1 0.753 1 0.671 1 0.954 1 1.267 1 49 0 2 657.36652 -3.53 12.98 1313.72576

CFSLVESTYK GNPTG N-acetylglucosamine-1-phosphotransferase subunit gamma precursor [Homo sapiens]

84572 NP_115909 4 1 14249738 C1(Methylthio); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.17 1 0.699 1 0.896 1 1.282 1 1.091 1 1.561 1 1.217 1 32 0 3 438.58353 12.18 21.52 1313.73603

CGIAVAPVSR DPP4 dipeptidyl peptidase 4 [Homo sapiens]

1803 NP_001926 2 1 18765694 C1(Methylthio); N-Term(iTRAQ4plex)

1.469 5 6.4 1.001 5 13.1 1.345 5 15.5 1.387 5 2.3 1.595 5 9.9 1.547 5 5.4 1.111 5 2.6 3.81 0 3 1027.4799 -7.49 46.91 3080.42502

CGLVPVLAENYK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 4 2 312433998 C1(Methylthio); N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.573 1 1.004 1 0.537 1 0.535 1 0.612 1 0.61 1 1.14 1 66 5.36 0 2 772.90833 -6.83 38.21 1544.80937

CGPCFNNGVPILEGTSCR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 6 1 4557389 C1(Methylthio); N-Term(iTRAQ4plex); C4(Methylthio); C17(Methylthio)

0.399 1 0.962 1 0.349 1 0.362 1 0.435 1 0.452 1 1.247 1 64 6.3 0 3 527.29053 -0.57 45.6 1579.85703

CGPLMDCR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 6 1 205277383 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio)

1.456 2 16 0.963 2 3.1 1.294 2 6.6 1.345 2 9.7 1.561 2 21.1 1.621 2 24.3 1.206 2 14.3 96 7.26 0 3 904.47217 -2.72 23.65 1807.93375

CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNK

CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

5 2 118442839;62739186

C1(Methylthio); N-Term(iTRAQ4plex); C30(Methylthio); K40(iTRAQ4plex)

1.309 2 7.2 0.881 2 3.7 1.14 2 11.4 1.295 2 7.7 1.321 2 6.9 1.5 2 3.1 1.158 2 4.5 54 4.28 0 2 723.90637 -1.3 31.7 1446.80644

CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR

CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

17 2 118442839;62739186

C1(Methylthio); N-Term(iTRAQ4plex); C30(Methylthio); K40(iTRAQ4plex)

1.091 1 0.905 1 1.005 1 1.111 1 1.074 1 1.187 1 1.068 1 49 3.9 0 2 660.87543 3.27 34.3 1320.74358

CGSEAQPR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 3 1 205277383 C1(Methylthio); N-Term(iTRAQ4plex)

1.226 1 0.922 1 1.15 1 1.247 1 1.206 1 1.308 1 1.049 1 47 4.04 0 2 762.88092 -1.19 47.09 1524.75456

CGVALSTPGGAR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 C1(Methylthio); N-Term(iTRAQ4plex)

1.184 2 11 0.994 2 17.7 1.139 2 2 1.145 2 19.7 1.226 2 2.4 1.233 2 20.1 1.077 2 0.4 47 3.58 0 2 687.86987 2.07 36.28 1374.73247

CHEGGQSYK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

4 6 47132549;16933542

C1(Methylthio); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.295 1 0.985 1 1.193 1 1.211 1 1.377 1 1.398 1 1.155 1 40 3.5 0 2 632.79865 0.4 22.53 1264.59001

CHEGYSLLADGVSCTPTVEYPCGK

F7 coagulation factor VII isoform b precursor [Homo sapiens]

2155 NP_062562 2 2 10518503 C1(Methylthio); N-Term(iTRAQ4plex); C14(Methylthio); C22(Methylthio); K24(iTRAQ4plex)

1.097 1 0.93 1 0.999 1 1.074 1 1.119 1 1.203 1 1.119 1 32 2.97 0 2 495.78799 -1.37 24.05 990.56871

CHPGYKPTTDEPTTVICQK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 12 1 4502503 C1(Methylthio); N-Term(iTRAQ4plex); K6(iTRAQ4plex); C17(Methylthio); K19(iTRAQ4plex)

1.813 9 15.4 0.968 9 11 1.675 9 15.8 1.816 9 10.3 1.94 9 13.7 2.047 9 10.4 1.164 9 3.7 125 6.42 0 3 1159.1017 5.78 33.41 2317.19609

CHPLVDPEPFVALCEK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); C14(Methylthio); K16(iTRAQ4plex)

1.046 21 17.1 0.994 21 11.9 0.9 21 12.9 0.956 21 18.3 1.111 21 20.2 1.124 21 23.6 1.155 21 5.8 120 7.85 0 3 1159.1017 5.78 33.41 2301.20029

CIEGQEK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 1 1 110611237 C1(Methylthio); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.062 105 18.9 0.909 105 21 0.95 105 23 0.996 105 19.9 1.095 105 21.2 1.158 105 24.5 1.156 105 21.6 116 9.27 0 3 1484.236 1.9 59.06 2967.45683

CIEGTCVCK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 19 1 119392081 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); C8(Methylthio); K9(iTRAQ4plex)

1.159 34 8 0.937 34 11.5 1.084 34 13.9 1.119 34 12.9 1.216 34 13.4 1.271 34 14.4 1.113 34 15.8 112 6.57 0 3 1179.5549 -1.71 25.29 2358.10259

CINQLLCK SEPP1 selenoprotein P isoform 1 precursor [Homo sapiens]

6414 NP_005401 11 2 62530391 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio); K8(iTRAQ4plex)

1.083 38 9.7 0.944 38 11.5 1.001 38 15.6 1.056 38 12 1.094 38 12.6 1.176 38 10.4 1.097 38 6.9 111 8.06 0 3 1220.2111 1.91 80.74 2439.41484

CINQSICEK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 3 21450863 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

1.548 8 11.1 1.049 8 11.3 1.638 8 9.7 1.474 8 14.7 1.703 8 15.1 1.562 8 11.9 1.098 8 10 109 5.47 0 2 812.46655 -5.58 40.35 1623.93083

CKPVNTFVHEPLVDVQNVCFQEK

RNASE1 ribonuclease pancreatic precursor [Homo sapiens]

6035 NP_002924 3 1 4506547 C1(Methylthio); N-Term(iTRAQ4plex); K2(iTRAQ4plex); C19(Methylthio); K23(iTRAQ4plex)

0.596 17 46.4 0.998 17 9.9 0.56 17 46.3 0.553 17 51.8 0.643 17 54.1 0.607 17 59.4 1.146 17 15.2 108 7.11 0 3 1146.0919 0.73 37.4 2291.18149

CLADGNPPPHFSISK MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 1 1 71274107 C1(Methylthio); N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.111 5 10.9 0.876 5 19.6 0.946 5 15 1.116 5 13.7 1.108 5 9 1.342 5 7.7 1.267 5 1.9 107 9.51 0 3 908.13794 -4.08 43.35 2722.40805

CLAEGGK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.252 13 10.7 0.936 13 11.1 1.115 13 6.9 1.181 13 10.8 1.306 13 12.7 1.354 13 15.9 1.164 13 6.3 107 5.89 0 2 981.0022 1.35 48.61 1960.99492

CLAFECPENYR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

13 4 34734066;34734062

C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio)

1.133 14 11.8 0.881 14 22.3 0.999 14 18.2 1.055 14 26.3 1.157 14 21 1.244 14 29.2 1.083 14 13.4 106 8.5 0 4 1484.236 1.9 59.06 2983.44889

CLANGGIHYITLDGR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

1 1 154146262 C1(Methylthio); N-Term(iTRAQ4plex)

1.197 8 17.2 0.892 8 9 1.094 8 12.3 1.206 8 7.6 1.272 8 15.6 1.411 8 24 1.158 8 13.5 106 8.77 0 3 880.09113 3.25 31.22 2638.26102

CLAPLEGAR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 19 1 21071030 C1(Methylthio); N-Term(iTRAQ4plex)

1.274 6 13.3 0.915 6 2.8 1.214 6 3.5 1.314 6 18.8 1.237 6 8.1 1.345 6 17.4 1.053 6 8.6 103 8.06 1 3 590.99896 -0.44 23.3 1770.98343

CLAYDFYPGK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 65 1 4502337 C1(Methylthio); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.197 15 13.9 0.916 15 8.1 1.058 15 15 1.155 15 20.3 1.202 15 7.6 1.363 15 11 1.143 15 6.1 101 7.35 1 3 1141.629 5.43 39.63 2282.23972

CLCACPFK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 13 1 4502511 C1(Methylthio); N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio); K8(iTRAQ4plex)

1.319 15 13.2 1.02 15 17.1 1.399 15 17 1.267 15 9.4 1.486 15 21.2 1.38 15 11.2 1.103 15 8.4 100 5.48 0 3 1084.0504 -0.7 59.76 2167.09355

CLCLPGYVPSDKPNYCTPLNTALNLEK

LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 1 5 261337173 C1(Methylthio); N-Term(iTRAQ4plex); C3(Methylthio); K12(iTRAQ4plex); C16(Methylthio); K27(iTRAQ4plex)

1.113 5 8 0.896 5 20.9 1.068 5 12.7 1.125 5 4.6 1.137 5 8.5 1.263 5 3.9 1.095 5 1.3 98 6.1 0 3 842.89563 -4.37 20.87 1684.78635

CLDPCVISQEIMEK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 27 1 5031695 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); K14(iTRAQ4plex)

1.086 28 14 0.974 28 16.8 1.005 28 11.9 1.055 28 18.2 1.177 28 11.4 1.204 28 17.1 1.165 28 8.6 97 5.66 0 2 1034.0164 -4.2 36.14 2067.02544

CLDPCVISQEIMEK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 1 1 5031695 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); M12(Oxidation); K14(iTRAQ4plex)

1.167 9 8.2 0.83 9 12.2 1.029 9 7.9 1.185 9 12.5 1.145 9 7.3 1.426 9 17.2 1.168 9 13.1 97 6.73 0 3 829.44855 -1.23 33.49 2486.33109

CLDPCVVSEENMNK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 6 1 13540563 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); K14(iTRAQ4plex)

1.255 27 12.2 0.959 27 20.7 1.157 27 13.6 1.234 27 14 1.333 27 15 1.378 27 17.2 1.173 27 14.3 96 7.34 0 3 1273.1558 -2.22 81.1 2545.30425

CLDPVDTPNPTR SLPI antileukoproteinase precursor [Homo sapiens]

6590 NP_003055 2 1 4507065 C1(Methylthio); N-Term(iTRAQ4plex)

1.194 9 18.1 0.939 9 32.6 1.195 9 18.6 1.122 9 6.9 1.378 9 22.9 1.229 9 11.7 1.133 9 6.9 95 5.82 0 2 785.41028 8.51 17.81 1569.81328

CLEVEGHR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 3 1 145275213 C1(Methylthio); N-Term(iTRAQ4plex)

1.201 18 2.9 0.91 18 9.7 1.077 18 6.8 1.188 18 7.9 1.218 18 4 1.301 18 6 1.117 18 5.6 92 5.46 0 3 538.96558 0.11 37.82 1614.88199

CLHPCVISR CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

7 2 118442839;62739186

C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio)

1.11 41 13.5 0.973 41 9 1.067 41 17.3 1.106 41 15.9 1.186 41 15.1 1.247 41 12.4 1.102 41 11.7 90 6.39 0 3 1019.5815 2.97 81.62 2038.15825

CLLFSFLPASSINDMEK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 12 1 78191798 C1(Methylthio); N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.466 2 22.3 0.828 2 40.5 1.16 2 44.5 1.401 2 3.5 1.542 2 39 1.863 2 1.4 1.329 2 4.9 90 7.79 1 3 1137.87 -1.29 55.11 3411.59543

CLLFSFLPASSINDMEK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 11 1 78191798 C1(Methylthio); N-Term(iTRAQ4plex); M15(Oxidation); K17(iTRAQ4plex)

1.172 28 12.5 0.989 28 7.6 1.097 28 11.5 1.117 28 11.4 1.211 28 12.7 1.232 28 14.8 1.115 28 5.1 90 5.77 0 2 817.45465 -1.21 34.05 1633.89922

CLNNQQLHFLHIGSCQDGR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 9 1 169636415 C1(Methylthio); N-Term(iTRAQ4plex); C15(Methylthio)

2.026 5 19.5 1.079 5 1.9 1.885 5 30.6 1.794 5 17.3 2.342 5 27.1 2.171 5 8.1 1.183 5 5.5 89 5.42 0 3 972.53876 -0.65 46.27 1944.0712

CLNTAELSESDMVPGTILVTEEELSR

TANGO6 transmembrane and coiled-coil domain-containing protein 7 [Homo sapiens]

79613 NP_078838 XP_933328 XP_945524

1 1 153791502 C1(Methylthio); N-Term(iTRAQ4plex)

1.253 10 21.3 1.048 10 15.7 1.102 10 10.3 1.145 10 31.5 1.321 10 18.9 1.44 10 22 1.116 11 10.6 89 9.8 0 3 1180.2587 -0.03 38.9 3538.76145

CLPDGTWR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 10 1 169636415 C1(Methylthio); N-Term(iTRAQ4plex)

1.095 122 12.7 0.967 122 12.5 0.997 122 13 1.053 122 17 1.137 122 14 1.201 122 17.2 1.143 122 11.2 88 6.52 0 3 908.48126 0.45 82.26 1815.95525

CLPSACEVVTGSPR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 5 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio)

1.181 19 7.1 1.042 19 11.4 1.145 19 13.8 1.186 19 8.7 1.268 19 15 1.269 19 9.9 1.108 19 5.7 87 7.49 0 3 692.72772 -2.22 37.07 2076.16953

CLPTACTIQLR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio)

1.257 10 10 0.946 10 19.1 1.104 10 11.9 1.234 10 17.9 1.288 10 14 1.443 10 13.3 1.148 10 10.7 87 6.57 0 3 1294.7166 6.37 75.84 2588.42583

CLPVCGKPVNPVEQR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

2 1 66347875 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); K7(iTRAQ4plex)

1.921 3 9.8 1.058 3 11.6 1.801 3 9.3 1.839 3 3.3 2 3 16.3 2.043 3 4.6 1.111 3 1.3 87 7.39 0 3 898.48535 1.06 18.51 1795.96396

CLPVTAPENGK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 4 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.205 45 16.7 0.951 45 31.9 1.064 45 23.6 1.099 45 26.4 1.223 45 19.4 1.269 45 29.3 1.13 45 18.4 87 9.46 0 3 1426.7498 -1.62 30.45 2852.48874

CLVNLIEK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 140 1 67782358 C1(Methylthio); N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.177 17 10.1 0.994 17 10.4 1.016 17 18.9 1.13 17 12.8 1.244 17 16.3 1.259 17 10.6 1.166 17 8.6 86 6.74 0 3 1039.5557 1.11 41.05 2078.11308

CLVNLIEKVASYGVKPR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 2 1 67782358 C1(Methylthio); N-Term(iTRAQ4plex); K8(iTRAQ4plex); K15(iTRAQ4plex)

1.233 48 8.2 1.005 48 8 1.171 48 10.7 1.181 48 9.9 1.319 48 8.8 1.308 48 11.3 1.131 48 9.3 85 6.27 0 2 1042.5454 0.52 73.19 2084.08097

CMCIK PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 4 1 4505981 C1(Methylthio); N-Term(iTRAQ4plex); C3(Methylthio); K5(iTRAQ4plex)

1.019 5 6.9 0.974 5 4.4 0.856 5 10.2 0.977 5 18.6 1.045 5 2.7 1.088 5 2.9 1.113 5 13.8 84 6.85 0 3 898.48535 1.06 18.51 1779.96988

CMVQVGVISGFK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.124 23 4.9 0.906 23 9.1 1.039 23 15 1.163 23 7.5 1.159 23 8.3 1.231 23 6.1 1.073 23 9.8 83 7.67 0 3 1204.1244 0.27 44.85 2407.2415

CNDQDTR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

3 6 47132549;16933542

C1(Methylthio); N-Term(iTRAQ4plex)

1.114 78 10.9 0.974 78 10.8 1.038 78 14.2 1.074 78 11.4 1.157 78 13.4 1.191 78 13.1 1.132 78 7.1 83 6.5 0 3 893.42932 -11.05 37.82 1785.85137

CNEYYLLR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 2 1 110611237 C1(Methylthio); N-Term(iTRAQ4plex)

1.203 21 15.8 0.951 21 12.9 1.082 21 14.1 1.14 21 8.7 1.267 21 12.3 1.258 21 12.2 1.162 21 7.9 81 5.24 0 2 828.46692 1.69 55.03 1655.92656

CNGDNDCGDFSDEDDCESEPRPPCR

C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 20 1 4502511 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio); C16(Methylthio); C24(Methylthio)

1.167 17 10.3 0.895 17 24.5 1.061 17 23.5 1.086 17 11 1.191 17 18.8 1.257 17 14 1.128 17 4.7 79 5.01 0 2 789.3844 2.08 27 1577.76152

CNLLAEK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 265 1 156523970 C1(Methylthio); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.26 3 13.1 0.894 3 18.7 1.057 3 3.2 1.34 3 6.4 1.332 3 12.8 1.517 3 10.2 1.161 3 3.7 79 4.31 0 2 971.54645 -1.66 52.38 1942.09172

CNMGYEYSER CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 39 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex)

1.404 4 2.6 0.927 4 7.1 1.319 4 9.2 1.417 4 9.8 1.539 4 11.8 1.561 4 13.9 1.217 4 10.1 78 6.58 0 3 1273.1558 -2.22 81.1 2561.30637

CNMGYEYSER CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 8 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex); M3(Oxidation)

1.347 9 6.8 0.94 9 20 1.171 9 20.7 1.241 9 25.7 1.321 9 38.9 1.298 9 34.8 1.033 9 49.1 77 7.12 0 3 1026.1549 3.15 62.04 3076.45017

CNPDSNSANCLEEK SRGN serglycin precursor [Homo sapiens] 5552 NP_002718 8 1 45935371 C1(Methylthio); N-Term(iTRAQ4plex); C10(Methylthio); K14(iTRAQ4plex)

1.167 16 25.9 0.928 16 28.6 0.998 16 23.4 1.131 16 19.9 1.036 16 30.9 1.199 16 25.7 1.056 16 21.1 77 7.07 1 3 1522.2493 -1.14 27.01 3043.49126

CNPGTGQCVCPAGWVGEQCQHCGGR

ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 6 2 21450863 C1(Methylthio); N-Term(iTRAQ4plex); C8(Methylthio); C10(Methylthio); C19(Methylthio); C22(Methylthio)

1.369 13 7.1 0.87 13 20.7 1.153 13 27.8 1.391 13 11.9 1.396 13 10.6 1.643 13 12.6 1.166 13 8.3 76 5.33 0 3 893.42932 -11.05 37.82 1801.86271

CPAPVSFENGIYTPR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 4 1 14550407 C1(Methylthio); N-Term(iTRAQ4plex)

1.565 7 24.9 0.997 7 35.5 1.228 7 13.7 1.454 7 33.1 1.434 7 9.3 1.436 7 17.1 1.107 7 19.8 75 7.93 0 3 1426.7498 -1.62 30.45 2868.46836

Page 6: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

CPEALFQPSFLGMESCGIHETTFNSIMK

ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 8 2 4501885 C1(Methylthio); N-Term(iTRAQ4plex); C16(Methylthio); K28(iTRAQ4plex)

1.048 8 6.9 1.034 8 18.1 1.039 8 10.9 0.97 8 12.8 1.238 8 13 1.121 8 17.1 1.154 8 8.2 75 4.77 0 3 972.53876 -0.65 46.27 1928.07566

CPFPSRPDNGFVNYPAKPTLYYK

APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 10 1 153266841 C1(Methylthio); N-Term(iTRAQ4plex); K17(iTRAQ4plex); K23(iTRAQ4plex)

1.284 12 11.5 0.906 12 25.4 1.106 12 25.8 1.203 12 11.1 1.438 12 14.8 1.45 12 17.6 1.192 12 7 75 6.31 0 3 1227.6105 2.81 40.15 2454.20293

CPINCLLGDFGPWSDCDPCIEK

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 4 1 169636415 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); C16(Methylthio); C19(Methylthio); K22(iTRAQ4plex)

1.287 11 7.1 1.032 11 8.4 1.237 11 16.1 1.225 11 5 1.392 11 7.9 1.315 11 5.9 1.105 11 4 75 4.36 0 2 748.90759 1.18 33.84 1496.80791

CPLFEHFLK IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 4 3 19882209 C1(Methylthio); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.155 5 8.4 0.861 5 18.6 1.13 5 33.8 1.037 5 13.1 1.279 5 14.9 1.283 5 38.4 1.133 5 0.3 75 5.88 0 3 1065.6022 0.95 31.43 2130.19663

CPLMVK TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 1 1 4507725 C1(Methylthio); N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.158 5 39.5 0.692 5 26.3 1.019 5 63.9 1.096 5 14.8 1.226 5 28.5 1.198 5 13.4 1.156 5 9.3 74 9.93 1 4 1137.87 -1.29 55.11 3395.60488

CPPPPLPINSK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 13 1 110611237 C1(Methylthio); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.206 8 6.2 1.037 8 25.1 1.152 8 9.5 1.079 8 30.7 1.294 8 10 1.222 8 9.5 1.152 8 13.6 74 4.64 0 2 717.35834 -0.53 23.94 1433.71062

CPSSGTPNPTLR FGFR1 fibroblast growth factor receptor 1 isoform 4 precursor [Homo sapiens]

2260 NP_075594 2 7 13186236 C1(Methylthio); N-Term(iTRAQ4plex)

1.221 2 24.1 0.888 2 36.5 1.098 2 42.4 1.237 2 5.3 1.223 2 41.7 1.378 2 4.7 1.114 2 0.6 73 4.24 0 2 757.92877 -6.66 16.29 1514.85027

CQAYESNR AFM afamin precursor [Homo sapiens] 173 NP_001124 10 1 4501987 C1(Methylthio); N-Term(iTRAQ4plex)

1.248 8 4.5 0.901 8 7.9 1.078 8 8.8 1.197 8 6.8 1.282 8 11.4 1.423 8 6.2 1.189 8 5.3 72 5.39 0 3 908.48126 0.45 82.26 1831.94785

CQCDELCSYYQSCCTDYTAECKPQVTR

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 26 1 88853069 C1(Methylthio); N-Term(iTRAQ4plex); C3(Methylthio); C7(Methylthio); C13(Methylthio); C14(Methylthio); C21(Methylthio); K22(iTRAQ4plex)

1.24 3 39.1 0.963 3 5.1 1.141 3 30.7 1.185 3 25.2 1.293 3 27.7 1.343 3 4.9 1.287 3 19.1 71 6.87 0 3 832.14026 1.83 81.47 2494.40696

CQFFSYATQTFHK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 2 1 78191798 C1(Methylthio); N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.263 2 10.6 0.939 2 28.7 1.16 2 24 1.234 2 4.4 1.3 2 25.1 1.384 2 3.4 1.121 2 1 71 3.83 0 2 670.3349 2.72 16.11 1339.66252

CQFFTYSLLPEDCK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 3 1 78191798 C1(Methylthio); N-Term(iTRAQ4plex); C13(Methylthio); K14(iTRAQ4plex)

1.083 2 11.8 0.919 2 5.5 0.92 2 20.6 1.001 2 14.9 1.156 2 9.8 1.258 2 4.2 1.257 2 10.6 71 4.53 1 3 559.97308 2.18 13.74 1677.9047

CQHEMDQYWGIGSLASGINLFTNSFEGPVLDHR

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 18 1 4557391 C1(Methylthio); N-Term(iTRAQ4plex)

1.011 1 1.101 1 1.027 1 0.933 1 1.097 1 0.996 1 1.068 1 70 4.9 0 2 912.91772 0.44 72.21 1824.82817

CQHEMDQYWGIGSLASGINLFTNSFEGPVLDHR

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 12 1 4557391 C1(Methylthio); N-Term(iTRAQ4plex); M5(Oxidation)

1.09 27 12.8 1.053 27 12.5 1.091 27 14.6 1.028 27 11.7 1.194 27 11 1.159 27 11 1.114 27 3.3 69 5.13 0 2 720.90997 2.57 31.89 1440.81267

CQIAGWGHLDENVSGYSSSLR

HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 12 1 4504383 C1(Methylthio); N-Term(iTRAQ4plex)

0.986 9 6 0.943 9 49.4 0.938 9 22.2 0.995 9 36 0.978 9 27.6 1.067 9 17.6 1.043 9 31 69 8.23 0 4 1785.9357 3.76 72.77 3570.84975

CQPSPDEARPLQALLDGR IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 9 2 62243068 C1(Methylthio); N-Term(iTRAQ4plex)

1.377 11 9.7 0.979 11 6.4 1.262 11 11 1.294 11 12.1 1.457 11 10 1.494 11 11.7 1.145 11 5.4 68 4.75 0 2 670.85938 -3.12 24.36 1340.71489

CQPVDCGIPESIENGK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 8 1 41393602 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); K16(iTRAQ4plex)

1.053 4 6.3 0.912 4 3.6 0.984 4 3.8 1.024 4 13.1 1.101 4 10.1 1.135 4 7.3 1.153 4 3.2 68 5.58 0 3 1090.1449 1.08 21.06 2179.28244

CQPVDCGIPESIENGKVEDPESTLFGSVIR

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 14 1 41393602 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); K16(iTRAQ4plex)

1.319 9 7.5 1.028 9 9.7 1.235 9 12.2 1.237 9 6.7 1.388 9 14.4 1.405 9 6.9 1.149 9 3.2 67 3.82 0 2 651.34363 -2.8 36.24 1301.67815

CRPPVGCEELVR IGFBP4 insulin-like growth factor-binding protein 4 precursor [Homo sapiens]

3487 NP_001543 10 1 62243290 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio)

0.959 25 16.7 0.949 25 26.8 0.894 25 26.6 0.969 25 18.8 1.088 25 26.8 1.075 25 24.7 1.135 25 23.5 66 7.5 0 3 1013.1775 -0.54 62.1 3037.52579

CSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAER

F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 2 1 145275213 C1(Methylthio); N-Term(iTRAQ4plex); C17(Methylthio); C28(Methylthio); C38(Methylthio)

1.059 12 10.6 1.057 12 13.7 1.029 12 17.8 1.006 12 6.3 1.18 12 20.8 1.119 12 8.2 1.146 12 3.2 66 5.13 0 2 782.8443 -3.68 28.56 1564.68132

CSASTSK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 2 1 169636415 C1(Methylthio); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.247 12 13.7 0.975 12 14.2 1.177 12 23.8 1.232 12 16 1.349 12 18.7 1.324 12 8 1.129 12 9 63 4.67 0 3 845.52002 -3.9 41.25 1690.03873

CSGEEQSLEQCQHR CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 6 1 5174411 C1(Methylthio); N-Term(iTRAQ4plex); C11(Methylthio)

1.102 29 7.4 0.978 29 6.3 1.018 29 8.9 1.061 29 5.8 1.179 29 6.5 1.197 29 5.1 1.138 29 5.1 63 5.32 0 2 900.90662 0.34 48.46 1800.80596

CSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 2 1 4505881 C1(Methylthio); N-Term(iTRAQ4plex); C28(Methylthio); K34(iTRAQ4plex)

1.258 9 5.6 0.949 9 15 1.185 9 12 1.199 9 12.7 1.361 9 6.7 1.334 9 15.8 1.114 9 14.2 62 8.76 1 3 1381.7261 1.68 49.7 2762.44487

CSLLVLENELNAELGLSGASMK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 19 1 105990532 C1(Methylthio); N-Term(iTRAQ4plex); M21(Oxidation); K22(iTRAQ4plex)

1.592 4 8.5 0.888 4 3.1 1.47 4 0.9 1.639 4 5.5 1.565 4 1.9 1.768 4 6.4 1.128 4 10.6 62 5.93 0 3 733.4292 2.51 55.42 2198.27304

CSLLVLENELNAELGLSGASMK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 C1(Methylthio); N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.637 13 21.6 0.952 13 15.2 1.374 13 19.3 1.555 13 26.6 1.871 13 24.9 2.007 13 21.9 1.222 13 21.4 62 7.91 0 3 1013.1775 -0.54 62.1 3053.51987

CSPHLVLSALTSDNHGATYAFSGTHYWR

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 112 1 11321561 C1(Methylthio); N-Term(iTRAQ4plex)

1.229 6 12.8 0.955 6 29.7 1.009 6 8.2 1.155 6 15.2 1.244 6 14.8 1.335 6 9 1.162 6 5.5 62 8.65 0 3 960.73834 1.27 32.28 2880.19571

CSSNLVLTGSSER C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 23 3 14550407 C1(Methylthio); N-Term(iTRAQ4plex)

1.495 1 1.059 1 1.566 1 1.479 1 1.512 1 1.428 1 0.965 1 61 7.01 0 3 1180.2587 -0.03 38.9 3554.77658

CSTSPLLEACEFLR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 C1(Methylthio); N-Term(iTRAQ4plex); C10(Methylthio)

1.026 12 18.7 1.03 12 30.8 0.993 12 16.2 1.034 12 15.5 1.057 12 16 1.116 12 17.2 1.089 12 7.3 60 3.25 0 2 565.87274 -0.49 19.27 1130.73247

CSVADVYPFDR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 3 4507875 C1(Methylthio); N-Term(iTRAQ4plex)

0.864 5 22.3 1.221 5 21.6 0.94 5 22 0.709 5 19.4 1.035 5 7.9 0.864 5 34.6 1.109 5 17.3 59 3.27 0 2 580.35986 -14.2 19.1 1159.73308

CSVFYGAPSK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

183 6 178557739;67190748

C1(Methylthio); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.214 10 10.7 1.011 10 16.3 1.161 10 16.2 1.144 10 10 1.35 10 8.6 1.254 10 7.9 1.128 10 7 58 3.97 0 2 690.9187 -2.88 35.45 1380.83

CSYTEDAQCIDGTIEVPK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 155 1 153266841 C1(Methylthio); N-Term(iTRAQ4plex); C9(Methylthio); K18(iTRAQ4plex)

1.151 12 8.1 1.006 12 15.5 1.118 12 11.7 1.1 12 6.3 1.255 12 12.9 1.245 12 4.9 1.127 12 2.9 58 3.51 0 2 714.3772 1.54 30.86 1427.74712

CTASNFLGTATHDFHVIVEEPPR

CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 C1(Methylthio); N-Term(iTRAQ4plex)

1.803 1 1.359 1 2.203 1 1.621 1 2.05 1 1.509 1 0.931 1 58 5.47 0 3 1042.5454 0.52 73.19 2100.07724

CTCGQGYQLSAAK LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 2 5 261337173 C1(Methylthio); N-Term(iTRAQ4plex); C3(Methylthio); K13(iTRAQ4plex)

1.231 3 5 1.008 3 13.2 1.049 3 17 1.04 3 3.8 1.411 3 9.8 1.281 3 9.6 1.2 3 1.6 58 4.09 0 2 703.3606 7.05 25.99 1405.70488

CTDAVGDR C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 8 1 4502511 C1(Methylthio); N-Term(iTRAQ4plex)

1.134 12 6.9 0.97 12 9.9 0.989 12 9 1.075 12 3.9 1.162 12 9.8 1.234 12 9.6 1.153 12 6.3 57 4.36 0 3 505.61749 2.9 32.67 1514.83271

CTDAVGDRR C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 3 1 4502511 C1(Methylthio); N-Term(iTRAQ4plex)

1.126 25 4.5 0.938 25 5.1 1.025 25 7.5 1.107 25 6.6 1.172 25 5.2 1.245 25 8.3 1.114 25 5.6 57 3.7 0 2 552.32886 -3.35 25.24 1103.65398

CTDDVHCHFFTYATR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio)

1.197 13 15.3 1.029 13 15.5 1.115 13 28.9 1.111 13 11 1.504 13 30.5 1.323 13 17.2 1.292 13 29.4 57 10.28 0 5 856.22278 5.07 54.99 4277.0854

CTEEGK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 9 1 153266841 C1(Methylthio); N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.215 16 5.8 0.898 16 16.3 1.083 16 10.3 1.166 16 12.4 1.256 16 8.7 1.349 16 11.1 1.168 16 6 56 5.43 0 3 1084.0968 3.97 47.28 2167.18633

CTEGFNVDK VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 85 1 88853069 C1(Methylthio); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.069 27 20.5 1.033 27 24.4 1.054 27 33 0.981 27 33.9 1.106 27 28.6 1.079 27 25 0.993 27 23.4 55 11.33 0 3 856.22278 5.07 54.99 4261.06885

CTEGFNVDKK VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 2 1 88853069 C1(Methylthio); N-Term(iTRAQ4plex); K9(iTRAQ4plex); K10(iTRAQ4plex)

1.255 16 5.4 1.006 16 7.1 1.15 16 10.8 1.208 16 9.5 1.311 16 9.5 1.335 16 7.2 1.146 16 5.7 54 5.64 0 3 672.71783 1.5 39.49 2016.13309

CTEPGDPLGGSAAIHLYVK CSF1R macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens]

1436 NP_005202 4 1 27262659 C1(Methylthio); N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.376 3 1.6 0.979 3 16.2 1.31 3 6.8 1.257 3 8.4 1.444 3 6.3 1.427 3 4.9 1.102 3 0.5 54 4.01 0 2 627.86908 1.74 34.44 1254.72698

CTKPDLSNGYISDVK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 2 1 110611237 C1(Methylthio); N-Term(iTRAQ4plex); K3(iTRAQ4plex); K15(iTRAQ4plex)

1.138 46 9.1 0.961 46 7.9 1.038 46 10.1 1.091 46 8.9 1.194 46 10.1 1.221 46 9.9 1.14 46 5.3 53 4 0 2 667.86603 1.66 69.95 1334.72478

CTLKPCDYPDIK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 64 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex); K4(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex)

1.119 17 10.1 0.976 17 12.3 1.048 17 14.7 1.034 17 5 1.189 17 10.4 1.178 17 6.8 1.15 17 6.5 51 4.19 0 2 614.33301 -1.24 33.69 1227.65874

CTSTGWIPAPR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 23 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex)

0.99 1 0.924 1 0.884 1 0.956 1 1.021 1 1.105 1 1.156 1 51 0 2 748.90759 1.18 33.84 1512.79411

CTSYPDGSWK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 8 1 40317626 C1(Methylthio); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.035 2 8.9 0.886 2 5.1 0.909 2 8.7 1.026 2 3.5 1.043 2 13.7 1.177 2 8.6 1.147 2 5 51 4.01 0 3 670.68646 1.73 66.13 2010.04483

CTTPPPSSGPTYQCLK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 28 1 4505881 C1(Methylthio); N-Term(iTRAQ4plex); C14(Methylthio); K16(iTRAQ4plex)

1.193 21 16.8 0.98 21 23.4 1.064 21 25 1.183 21 12.8 1.2 21 26.8 1.344 21 10.8 1.134 21 2.7 50 3.42 0 3 587.86816 0.4 24.54 1174.72551

CTWLIEGQPNR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 8 3 21450863 C1(Methylthio); N-Term(iTRAQ4plex)

1.339 1 1.021 1 1.266 1 1.239 1 1.44 1 1.41 1 1.138 1 49 4.86 0 3 761.32544 3.33 81.16 2281.96177

CVCLLPPQCFK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 22 1 169636415 C1(Methylthio); N-Term(iTRAQ4plex); C3(Methylthio); C9(Methylthio); K11(iTRAQ4plex)

0.921 4 8 0.998 4 14.2 0.835 4 7.7 0.839 4 15.4 1.001 4 6.1 1.01 4 13.4 1.202 4 0.8 49 5.02 1 3 660.98157 0.83 65.77 1980.93015

CVDGCSCPEGQLLDEGLCVESTECPCVHSGK

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio); C7(Methylthio); C18(Methylthio); C24(Methylthio); C26(Methylthio); K31(iTRAQ4plex)

1.118 12 8 0.942 12 8.4 1.046 12 12.5 1.09 12 8.1 1.166 12 12.2 1.239 12 4 1.128 12 4.6 48 4.58 0 2 692.34967 0.38 54.72 1383.69206

CVDIDECTQVQHLCSQGR LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 2 5 261337173 C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio); C14(Methylthio)

0.939 4 29.3 0.94 4 15.5 0.899 4 19.6 0.917 4 23.4 0.995 4 36.2 1.037 4 23.7 1.131 4 3.3 47 2.86 0 2 547.34467 -3.59 17.56 1093.68706

CVDVDECAPPAEPCGK FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

12 4 34734066;34734062

C1(Methylthio); N-Term(iTRAQ4plex); C7(Methylthio); C14(Methylthio); K16(iTRAQ4plex)

1.012 1 0.909 1 0.89 1 0.979 1 1.042 1 1.147 1 1.171 1 45 3.38 1 2 740.40027 2.64 13.01 1479.79326

CVEADCGQMQEELDLTISAETR

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 24 2 38016947 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio)

0.947 1 0.948 1 0.922 1 0.973 1 0.923 1 0.973 1 1.001 1 44 4.58 1 3 509.6478 2.03 16.07 1526.92884

CVEISCK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 82 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

1.102 4 14.8 1.018 4 17.1 1.035 4 21.3 1.017 4 8 1.188 4 22.5 1.167 4 9.1 1.156 4 1.6 43 4.8 1 3 500.62469 1.49 16.37 1499.85953

CVFWNFR GPR116 probable G-protein coupled receptor 116 precursor [Homo sapiens]

221395 NP_056049 1 1 148719673 C1(Methylthio); N-Term(iTRAQ4plex)

1.099 6 5.4 1.066 6 5.6 1.071 6 3.4 0.989 6 8.6 1.217 6 6.3 1.105 6 6.7 1.113 6 3.1 43 0 2 484.79791 -13.79 15.59 968.58855

CVGWNGQCSGK CFP properdin precursor [Homo sapiens] 5199 NP_001138724 2 1 223671861 C1(Methylthio); N-Term(iTRAQ4plex); C8(Methylthio); K11(iTRAQ4plex)

1.193 2 16.8 0.84 2 1.6 1.011 2 17 1.203 2 18.7 1.184 2 15.2 1.409 2 16.8 1.171 2 1.8 43 3.74 0 3 718.92755 0.99 14.21 1436.85093

CVLFPYGGCQGNGNK AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 16 1 4502067 C1(Methylthio); N-Term(iTRAQ4plex); C9(Methylthio); K15(iTRAQ4plex)

1.194 19 10.4 1.041 19 9.9 1.174 19 12 1.142 19 6 1.287 19 14.3 1.264 19 7 1.118 19 3.7 43 3.41 0 2 583.86267 -2.51 42.3 1166.72136

CVNSPGSFR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

3 4 34734066;34734062

C1(Methylthio); N-Term(iTRAQ4plex)

1.075 6 6.3 0.985 6 6.5 1.012 6 13.6 1.022 6 6.2 1.117 6 8.7 1.159 6 6.6 1.129 6 2.6 43 3.27 0 2 546.82928 0.89 13.84 1092.65093

CVNVIFVGDHGMEDVTCDR ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 4 3 91823602 C1(Methylthio); N-Term(iTRAQ4plex); C17(Methylthio)

1.11 143 7.5 0.954 143 12 1.005 143 14.5 1.059 143 6.6 1.15 143 12.8 1.2 143 4.5 1.136 143 4.4 43 0 2 545.34869 -0.88 36.86 1089.69219

CVPVCGVPR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 6 1 41393602 C1(Methylthio); N-Term(iTRAQ4plex); C5(Methylthio)

1.329 4 1.6 0.92 4 8.8 1.246 4 4.4 1.354 4 4.4 1.322 4 3.8 1.45 4 4.8 1.061 4 1.9 42 3.55 0 2 692.34967 0.38 54.72 1399.68486

CVQSTKPSLMIQK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 C1(Methylthio); N-Term(iTRAQ4plex); K6(iTRAQ4plex); K13(iTRAQ4plex)

0.959 1 0.651 1 0.717 1 1.101 1 0.867 1 1.331 1 1.209 1 41 2.95 0 2 510.29886 -6.99 14.46 1019.59044

CVSLLLDLSQPLLPSR CD93 complement component C1q receptor precursor [Homo sapiens]

22918 NP_036204 2 1 88758613 C1(Methylthio); N-Term(iTRAQ4plex)

0.949 1 0.807 1 0.79 1 0.978 1 0.926 1 1.147 1 1.172 1 39 0 2 465.30786 6.67 14.83 929.60845

CVWNTGSSQCISWALATDEQEEK

ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 4 3 21450863 C1(Methylthio); N-Term(iTRAQ4plex); C10(Methylthio); K23(iTRAQ4plex)

1.532 7 8 0.934 7 7.4 1.332 7 12.6 1.523 7 1.2 1.529 7 9 1.734 7 5.8 1.139 7 1.1 39 7.06 0 3 1204.1244 0.27 44.85 2423.22928

CVYLQTSMK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 C1(Methylthio); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.981 2 4.6 0.958 2 3 0.901 2 4.7 0.941 2 1.6 1.019 2 7.4 1.064 2 4.3 1.13 2 2.7 39 0 2 437.74115 -0.08 11.47 874.47502

CYFPYLENGYNQNHGR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 6 2 62739186 C1(Methylthio); N-Term(iTRAQ4plex)

1.255 16 20.1 1.024 16 16.2 1.206 16 23.2 1.27 16 6.3 1.215 16 35.4 1.435 16 7.6 1.129 16 6.1 39 3.1 0 2 588.84735 0.6 30.16 1176.68865

CYFPYLENGYNQNYGR CFHR3 complement factor H-related protein 3 isoform 2 precursor [Homo sapiens]

10878 NP_001160096 6 2 262231791 C1(Methylthio); N-Term(iTRAQ4plex)

1.159 2 6.7 0.97 2 12.9 1.068 2 10.4 1.101 2 2.5 1.217 2 15.5 1.256 2 2.5 1.14 2 5 39 5.54 1 3 594.0163 -0.94 29.88 1780.03434

CYGPGVGR CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 1 1 5174411 C1(Methylthio); N-Term(iTRAQ4plex)

1.244 1 1.178 1 1.137 1 0.965 1 1.573 1 1.336 1 1.384 1 38 3.72 0 3 1785.9357 3.76 72.77 3586.84275

CYPHPGSELPLQALVMGEGTCEK

IGFBP2 insulin-like growth factor-binding protein 2 precursor [Homo sapiens]

3485 NP_000588 2 1 55925576 C1(Methylthio); N-Term(iTRAQ4plex); C21(Methylthio); K23(iTRAQ4plex)

1.246 1 0.992 1 1.149 1 1.158 1 1.332 1 1.343 1 1.159 1 36 3.5 0 3 549.00049 -1.68 13.99 1644.98691

CYPHPGSELPLQALVMGEGTCEK

IGFBP2 insulin-like growth factor-binding protein 2 precursor [Homo sapiens]

3485 NP_000588 1 1 55925576 C1(Methylthio); N-Term(iTRAQ4plex); M16(Oxidation); C21(Methylthio); K23(iTRAQ4plex)

1.164 1 0.858 1 1.03 1 1.2 1 1.133 1 1.32 1 1.1 1 34 3.05 1 2 696.41974 -10.65 16.05 1391.8322

CYTAVVPLVYGGETK IGJ immunoglobulin J chain precursor [Homo sapiens]

3512 NP_653247 2 1 21489959 C1(Methylthio); N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.936 1 1.137 1 0.998 1 0.878 1 1.003 1 0.882 1 1.005 1 34 4.66 2 4 564.03601 -1.47 53.88 2253.12221

DAAQCSGGDVAR GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 7 1 4758460 N-Term(iTRAQ4plex); C5(Methylthio)

1.169 1 0.677 1 0.899 1 1.327 1 1.061 1 1.567 1 1.181 1 33 0 2 478.27112 1.13 14.86 955.53496

DACAGDSGGPMVTLNR MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 6 1 21264357 N-Term(iTRAQ4plex); C3(Methylthio)

1.467 5 5.8 0.969 5 17.3 1.319 5 15.8 1.373 5 0.8 1.46 5 11.5 1.595 5 8.5 1.134 5 3.6 31 2.91 0 2 583.86267 -2.51 42.3 1182.71465

DADDLQK APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 7 1 4557325 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.028 1 0.915 1 0.868 1 0.948 1 1.102 1 1.204 1 1.269 1 30 2.95 0 2 521.79407 0.63 17.99 1042.58086

DADPDTFFAK AFM afamin precursor [Homo sapiens] 173 NP_001124 28 1 4501987 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.73 1 0.898 1 0.637 1 0.71 1 0.748 1 0.833 1 1.174 1 28 0 2 525.17719 0.69 17.99 1049.34709

DAEAWFNEK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

8 5 195972866 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.185 1 1.022 1 1.111 1 1.087 1 1.286 1 1.258 1 1.158 1 15 0 2 525.17719 0.69 17.99 1065.34087

DAEEWFFTK KRT14 keratin, type I cytoskeletal 14 [Homo sapiens]

3861 NP_000517 4 1 15431310 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.506 1 0.976 1 1.542 1 1.579 1 1.435 1 1.47 1 0.931 1 9.6 0 4 856.22278 5.07 54.99 4293.06215

DALENIDPATQMMILNCIYFK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 2 1 73858566 N-Term(iTRAQ4plex); M13(Oxidation); C17(Methylthio); K21(iTRAQ4plex)

1.16 1 1.004 1 1.106 1 1.101 1 1.219 1 1.213 1 1.102 1 4.03 1 3 500.27142 -5.67 15.49 1498.79972

DALENIDPATQMMILNCIYFK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 18 1 73858566 N-Term(iTRAQ4plex); C17(Methylthio); K21(iTRAQ4plex)

1.217 1 0.91 1 1.089 1 1.196 1 1.237 1 1.359 1 1.136 1 3.07 0 2 516.28406 0.6 26.55 1031.56084

DALSSVQESQVAQQAR APOC3 apolipoprotein C-III precursor [Homo sapiens]

345 NP_000031 21 1 4557323 N-Term(iTRAQ4plex) 1.202 1 0.985 1 1.116 1 1.133 1 1.27 1 1.289 1 1.138 1 2.84 0 2 532.841 3.82 19.19 1064.67473

DAPDHQELNLDVSLQLPSR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 33 1 115298678 N-Term(iTRAQ4plex) 1.329 2 7.1 0.964 2 5.4 1.235 2 12.8 1.282 2 7.3 1.375 2 7 1.427 2 1.6 1.113 2 5.7 3.22 0 2 681.37921 -0.27 15.97 1361.75115

DAPIVNK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

8 5 47132549;16933542

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.456 3 5 0.841 3 23.8 1.258 3 21 1.496 3 0.9 1.422 3 10.6 1.691 3 5.9 1.131 3 5 34 0 2 606.84674 -17.84 45.09 1212.6862

DAQEVHCDEATK BTD biotinidase precursor [Homo sapiens]

686 NP_000051 8 1 4557373 N-Term(iTRAQ4plex); C7(Methylthio); K12(iTRAQ4plex)

1.439 1 0.988 1 1.365 1 1.382 1 1.496 1 1.514 1 1.096 1 3.7 1 3 839.74042 8.64 48.5 2517.2067

DAQYAPGYDK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 16 1 67782358 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.017 1 0.905 1 0.879 1 0.972 1 1.059 1 1.17 1 1.204 1 83 5.44 0 2 748.91205 -2.08 25.98 1496.81682

DAVEDLESVGK DCD dermcidin preproprotein [Homo sapiens]

117159 NP_444513 2 1 16751921 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.72 1 0.833 1 0.628 1 0.754 1 0.692 1 0.831 1 1.103 1 82 5.81 0 3 476.91803 0.64 16.16 1428.73954

DAVEKPQEFTIVAFVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 7 1 105990532 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K16(iTRAQ4plex)

0.89 2 5 0.891 2 7.6 0.771 2 1.1 0.865 2 8.7 0.912 2 1.6 1.023 2 9.2 1.183 2 0.5 77 4.82 0 2 735.91132 -0.1 15.82 1470.81536

DCASHFEQMAAASMHR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

4 2 13325075 N-Term(iTRAQ4plex); C2(Methylthio)

0.972 2 10.6 0.895 2 0.8 0.902 2 2 1.008 2 2.8 0.936 2 18.4 1.046 2 19.2 1.038 2 16.3 61 7.62 0 3 884.82245 0.24 44.94 2652.45279

DCDDVLQTHPSGTQSGIFNIK

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 1 4503689 N-Term(iTRAQ4plex); C2(Methylthio); K21(iTRAQ4plex)

1.291 1 0.686 1 0.95 1 1.384 1 1.226 1 1.788 1 1.291 1 48 0 2 926.41931 -1.16 14.72 1851.83135

Page 7: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

DCELPR CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 1 1 119392081 N-Term(iTRAQ4plex); C2(Methylthio)

0.949 1 0.961 1 0.88 1 0.916 1 0.981 1 1.021 1 1.114 1 44 4.1 0 3 511.59921 -0.87 45.96 1532.78308

DCNTCICR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C2(Methylthio); C5(Methylthio); C7(Methylthio)

1.181 1 0.998 1 1.136 1 1.138 1 1.225 1 1.227 1 1.078 1 38 2.86 0 2 833.42792 7.73 16.78 1665.84856

DCSLPYATESK FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

7 4 34734066;34734062

N-Term(iTRAQ4plex); C2(Methylthio); K11(iTRAQ4plex)

0.927 1 1.136 1 1.055 1 0.929 1 0.924 1 0.814 1 0.876 1 5.86 1 4 874.17755 5.05 38.49 3493.68838

DCVGDVTENQICNK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 2 1 40317626 N-Term(iTRAQ4plex); C2(Methylthio); C12(Methylthio); K14(iTRAQ4plex)

1.089 1 0.975 1 1.022 1 1.048 1 1.129 1 1.158 1 1.105 1 4.03 0 2 802.45227 -4.62 19.86 1603.89726

DDEEFIESNK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 11 1 4557485 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.446 21 32.3 0.943 21 50.2 1.154 21 59.4 1.452 21 65.5 1.439 21 69.7 1.684 21 65.2 1.143 21 30.4 119 8.86 0 3 1296.0021 -1.78 68.06 3886.01218

DDFDHDSVPDIDDICPENVDISETDFR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 2 1 40317626 N-Term(iTRAQ4plex); C15(Methylthio)

1.826 37 40.8 0.895 37 42.9 1.578 37 44.1 1.793 36 86.6 1.896 37 43.3 2.004 35 63.4 1.167 37 36.4 111 9.45 0 3 1442.2633 1.29 75.54 2883.51933

DDFLIYDR SEPP1 selenoprotein P isoform 1 precursor [Homo sapiens]

6414 NP_005401 9 2 62530391 N-Term(iTRAQ4plex) 1.453 28 32.3 1.088 28 33.3 1.441 28 36.3 1.341 28 28.9 1.536 28 32.3 1.519 28 25.4 1.114 28 22.4 106 10.16 0 4 1442.2633 1.29 75.54 2867.53105

DDGLFSGDPNWFPK TAGLN2 transgelin-2 [Homo sapiens] 8407 NP_003555 2 1 4507357 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.661 13 14.3 1.058 13 20.3 1.65 13 11.2 1.529 13 14.3 1.844 13 14.4 1.728 13 9 1.149 13 5.3 89 5.96 0 2 930.98755 -0.88 34.76 1860.96782

DDKESVPISDTIIPAVPPPTDLR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

21 4 47132549;16933542

N-Term(iTRAQ4plex); K3(iTRAQ4plex)

1.38 9 12 0.822 9 5.1 1.294 9 9.8 1.437 9 14.7 1.343 9 22.8 1.649 9 28.6 1.147 9 5 88 10.06 0 3 739.40192 -0.07 37.41 2216.1912

DDKHEQDMVNGIMLSVEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); K3(iTRAQ4plex); M8(Oxidation); M13(Oxidation); K18(iTRAQ4plex)

1.163 19 8.2 0.927 19 20.8 1.087 19 13.8 1.174 19 10.3 1.24 19 19 1.319 19 24.1 1.087 19 21.3 86 6.6 0 2 1212.5753 -0.49 48.07 2424.14336

DDPDAPLQPVTPLQLFEGR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

4 6 178557739;67190748

N-Term(iTRAQ4plex) 3.051 4 33.2 0.947 4 53.2 2.694 4 59.7 2.558 4 38.9 3.647 4 45.3 3.607 4 9.4 1.353 4 31.1 83 6.37 0 3 1121.1353 -2.72 51.84 2241.27188

DDWFMLGLR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 1 4 7382460 N-Term(iTRAQ4plex); M5(Oxidation)

2.128 12 27.2 0.816 12 28.2 1.707 12 43.1 1.952 12 45.1 2.005 12 32.2 2.137 12 48.7 1.105 12 9.1 81 6.32 0 3 1212.5753 -0.49 48.07 2440.13449

DDWFMLGLR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 6 4 7382460 N-Term(iTRAQ4plex) 1.961 82 13.5 0.941 82 16.7 1.75 82 19.2 1.899 82 13.3 2.081 82 19.6 2.174 82 11.2 1.151 82 8 81 8.7 0 3 806.44989 3.74 59.41 2417.32651

DEAANTLIADYVAK COLEC10 collectin-10 precursor [Homo sapiens]

10584 NP_006429 2 1 256017186 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.402 5 16.7 0.954 5 4.7 2.259 5 16.9 2.382 5 22.7 2.42 5 7.7 2.552 5 21.5 1.09 5 2.5 76 4.48 0 3 1069.5474 7.28 27.72 2138.08463

DEANKIAENNDLLWMDYHQK

BIN1 myc box-dependent-interacting protein 1 isoform 10 [Homo sapiens]

274 NP_647601 1 10 21536417 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K20(iTRAQ4plex)

1.284 3 6.1 0.97 3 2.3 1.216 3 17.7 1.27 3 4.3 1.296 3 7.6 1.502 3 11.8 1.065 3 7.6 71 4.37 0 2 1069.5474 7.28 27.72 2122.09014

DEASSVEVTWPDGK CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 2 2 330688397 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.414 6 35 0.807 6 20.5 2.133 6 28.9 2.623 6 53.4 2.027 6 40.2 2.781 6 46.6 0.985 6 1.5 65 5.32 0 3 1212.5753 -0.49 48.07 2456.13425

DEELSCTVVELK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 214 1 50659080 N-Term(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex)

1.324 12 8.5 1.019 12 9.7 1.243 12 17.2 1.273 12 7.3 1.361 12 14.6 1.395 12 10.7 1.092 12 2.8 61 4.54 0 3 456.22983 1.52 50.57 1366.67493

DEEVVQCLSDGWSSQPTCR

F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 2 1 110611237 N-Term(iTRAQ4plex); C7(Methylthio); C18(Methylthio)

1.332 12 6.1 0.986 12 12.3 1.286 12 7.3 1.311 12 10.2 1.389 12 4.3 1.383 12 9 1.063 12 8.7 61 4.12 0 3 408.87476 0.61 7.48 1224.60971

DEGTAFLVYGAPGFSK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 5 1 4557351 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.579 3 4.2 1.006 3 5.7 1.459 3 8.4 1.339 3 3.4 1.649 3 19.1 1.693 3 0.9 1.131 3 7.1 59 2.9 0 2 800.95343 6.14 15.86 1600.89958

DEIPHNDIALLK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 4 2 295054188 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.52 1 1.035 1 1.637 1 1.582 1 1.456 1 1.407 1 0.89 1 52 6.04 0 3 919.17035 3.11 51.37 2755.49649

DELLFPSWEALFSGSEGPLKPGAR

COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 4 2 110611233 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.016 1 0.437 1 0.827 1 1.891 1 0.634 1 1.45 1 0.767 1 49 8.84 0 4 1296.0021 -1.78 68.06 3901.99941

DEPTYILNIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.582 4 4.1 0.844 4 7.9 1.413 4 3.7 1.65 4 8.8 1.545 4 4.9 1.805 4 10 1.103 4 3.3 48 3.23 0 2 645.82971 -0.54 2.5 1290.65154

DETHFEVVESGR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex) 1.441 10 16.6 0.999 10 4.9 1.428 10 13.7 1.419 10 8.9 1.583 10 12.8 1.563 10 10.5 1.11 10 3.3 43 0 2 539.3349 7.27 21.17 1077.66252

DETLQDGCDTHFCK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C8(Methylthio); C13(Methylthio); K14(iTRAQ4plex)

1.404 1 1.114 1 1.436 1 1.288 1 1.534 1 1.376 1 1.068 1 40 4.67 1 3 602.3313 1.55 10.55 1804.97934

DFAEHLLIPR PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 10 2 4506121 N-Term(iTRAQ4plex) 1.665 3 6 0.935 3 18.1 1.514 3 24.1 1.677 3 2.5 1.707 3 7.3 1.826 3 10.8 1.128 3 8.3 38 2.88 0 2 554.29895 -0.81 19.11 1107.59233

DFALLSLQVPLK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

138 6 178557739;67190748

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.669 15 8.7 1.03 15 8 1.623 15 11 1.563 15 9.7 1.832 15 11.5 1.736 15 9.8 1.111 15 2.8 36 3.54 0 2 569.83948 0.55 28.61 1138.66802

DFALLSLQVPLKDAK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex); K12(iTRAQ4plex); K15(iTRAQ4plex)

1.561 5 10.3 0.907 5 8 1.392 5 17.5 1.634 5 10.8 1.598 5 7.7 1.758 5 2 1.122 5 6.3 36 0 2 498.771 0.37 19.17 996.53472

DFALQNPSAVPR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 4 2 4826772 N-Term(iTRAQ4plex) 1.354 2 3 0.928 2 5 1.245 2 6.5 1.341 2 1.5 1.366 2 4.3 1.472 2 0.7 1.097 2 2.1 35 0 2 496.74265 0.59 15.95 992.47801

DFCGGVIIR PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 2 2 4506121 N-Term(iTRAQ4plex); C3(Methylthio)

1.457 2 2.3 0.827 2 1.5 1.217 2 10.6 1.472 2 9.1 1.441 2 3.4 1.742 2 5 1.184 2 14.1 29 6.94 1 5 861.23602 3.07 54.52 3441.92226

DFDFVPPVVR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 77 1 115298678 N-Term(iTRAQ4plex) 0.646 1 0.995 1 0.582 1 0.585 1 0.706 1 0.709 1 1.212 1 52 3.8 0 2 873.93945 2.05 21.95 1746.87163

DFEQPFINKPDTLLVNR FLT4 vascular endothelial growth factor receptor 3 isoform 2 precursor [Homo sapiens]

2324 NP_002011 1 2 103472027 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.509 1 0.829 1 1.267 1 1.528 1 1.494 1 1.801 1 1.179 1 73 7.09 0 3 649.01666 -0.94 35.12 1945.03543

DFGTHYITEAVLGGIYEYTLVMNK

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 22 1 4557391 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.963 3 17.6 0.951 3 0.9 1.858 3 30.2 1.836 3 20.5 2.093 3 5.4 2.068 3 6.4 1.126 3 13.9 56 3.61 0 2 593.81299 0.21 22.27 1186.6187

DFGTHYITEAVLGGIYEYTLVMNK

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 10 1 4557391 N-Term(iTRAQ4plex); M22(Oxidation); K24(iTRAQ4plex)

1.683 1 1.007 1 1.545 1 1.534 1 1.833 1 1.82 1 1.187 1 52 3 0 2 585.81641 1.69 29.35 1170.62554

DFHINLFQVLPWLK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 59 1 67782358 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.717 1 0.907 1 1.569 1 1.731 1 1.704 1 1.879 1 1.086 1 49 3.5 0 2 578.80792 0.57 29.21 1156.60857

DFHINLFR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 5 3 14550407 N-Term(iTRAQ4plex) 1.189 1 0.987 1 1.086 1 1.1 1 1.277 1 1.293 1 1.176 1 88 4.38 0 2 699.36011 -0.89 30.03 1397.71294

DFISLGLQDGHLVFR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex) 1.247 3 3.4 0.926 3 6.6 1.212 3 0.7 1.282 3 2.9 1.238 3 6.1 1.374 3 2 1.065 3 0.9 77 8.25 0 3 655.36206 -0.32 44.75 1964.07163

DFLGFYVVDSHR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 7 1 133925809 N-Term(iTRAQ4plex) 1.063 1 0.851 1 0.949 1 1.115 1 1.018 1 1.196 1 1.073 1 50 4.85 0 2 773.90271 -0.07 49.43 1546.79814

DFLQSLK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 21 2 115583663 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.435 1 0.941 1 1.298 1 1.379 1 1.487 1 1.581 1 1.146 1 38 5.64 0 3 615.65485 1.07 41.72 1844.94999

DFNIPGFPTVR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

3 2 13325075 N-Term(iTRAQ4plex) 1.203 1 1.002 1 1.106 1 1.104 1 1.302 1 1.299 1 1.177 1 33 3.31 0 2 529.81158 7.91 29.78 1058.61589

DFPLVDGHNDLPLVLR DPEP2 dipeptidase 2 precursor [Homo sapiens]

64174 NP_071750 6 1 11641269 N-Term(iTRAQ4plex) 1.191 1 0.92 1 1.076 1 1.169 1 1.211 1 1.316 1 1.126 1 2.91 0 2 679.41357 1.98 37.48 1357.81987

DFQPVLHLVALNSPLSGGMR

COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 4 2 110611233 N-Term(iTRAQ4plex) 1.251 1 1.129 1 1.27 1 1.124 1 1.395 1 1.235 1 1.098 1 80 4.23 0 2 935.526 -4.14 31.92 1870.04473

DFSAEYEEDGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.73 1 0.919 1 2.612 1 2.841 1 2.628 1 2.859 1 1.006 1 51 6.92 0 4 951.99835 2.79 71.33 3804.97158

DFSAEYEEDGKYEGLQEWEGK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 35 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K21(iTRAQ4plex)

1.308 1 0.92 1 1.204 1 1.309 1 1.307 1 1.42 1 1.085 1 49 3.07 0 2 653.86084 1.55 22.91 1306.7144

DFSLWEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 34 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.26 1 0.835 1 1.133 1 1.357 1 1.178 1 1.411 1 1.04 1 40 3.99 0 3 618.68726 3.65 69.23 1854.04721

DFTAYR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 1 1 40317626 N-Term(iTRAQ4plex) 1.298 1 0.94 1 1.138 1 1.211 1 1.379 1 1.468 1 1.212 1 3.33 0 2 754.43994 0.2 33.96 1507.87261

DFTCVHQALK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 10 1 73858568 N-Term(iTRAQ4plex); C4(Methylthio); K10(iTRAQ4plex)

0.915 1 0.937 1 0.818 1 0.873 1 0.954 1 1.019 1 1.167 1 101 4.56 0 2 757.93823 -5.9 16.77 1514.86919

DFTFDLYR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 3 1 194018472 N-Term(iTRAQ4plex) 0.64 2 22.1 0.95 2 2 0.599 2 16.3 0.63 2 14.2 0.648 2 29.6 0.682 2 27.4 1.083 2 12.8 94 4.95 0 2 1060.5122 -1.64 50.03 2120.01714

DFVQPPTK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

8 3 4504893;156231037

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.764 3 11.9 0.812 3 17.3 0.681 3 4.8 0.839 3 22.2 0.756 3 10.8 0.867 3 15.2 1.199 3 4 90 6.51 0 3 1248.1014 -2.87 39.61 2495.20108

DFYVDENTTVR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 12 1 21361302 N-Term(iTRAQ4plex) 0.948 3 15.6 1.106 3 6.3 0.913 3 28.4 0.825 3 1.1 1.084 3 7.4 0.98 3 1 1.027 3 2.6 80 6.72 0 3 775.07819 -3.26 34.24 2323.23172

DGDQCETSPCQNQGK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 6 1 4503625 N-Term(iTRAQ4plex); C5(Methylthio); C10(Methylthio); K15(iTRAQ4plex)

1 3 0.2 0.931 3 6.1 0.937 3 2.3 0.913 3 15 0.959 3 19.3 1.047 3 3.8 1.081 3 8 66 3.98 0 2 703.92468 -5.46 40.9 1406.84209

DGEDQTQDTELVETRPAGDGTFQK

HLA-C HLA class I histocompatibility antigen, Cw-1 alpha chain precursor [Homo sapiens]

3107 NP_001229971 XP_003119292-XP_003119305 XP_003119407-XP 003119421

2 4 339882741 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

0.931 1 1.011 1 0.901 1 0.891 1 0.972 1 0.961 1 1.079 1 57 4.65 0 2 910.50146 1.14 21.89 1819.99565

DGEQIEQEEDDEK NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 1 5 115529482 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.986 1 0.954 1 0.935 1 0.98 1 0.991 1 1.039 1 1.06 1 56 7.23 0 3 874.79193 1.51 72.93 2622.36124

DGEQIEQEEDDEKYIFSDDSSQLTIK

NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 1 5 115529482 N-Term(iTRAQ4plex); K13(iTRAQ4plex); K26(iTRAQ4plex)

0.787 1 1 1 0.72 1 0.72 1 0.854 1 0.854 1 1.186 1 50 3.34 0 2 598.81519 1.35 41.03 1196.62309

DGEYVVEVR CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 2 2 28373119 N-Term(iTRAQ4plex) 0.773 1 0.833 1 0.652 1 0.783 1 0.764 1 0.918 1 1.172 1 48 3.19 0 2 872.9837 -1.37 33.93 1744.96013

DGFDISGNPWICDQNLSDLYR

LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 16 1 16418467 N-Term(iTRAQ4plex); C12(Methylthio)

0.897 1 0.769 1 0.741 1 0.963 1 0.847 1 1.101 1 1.143 1 34 3.13 0 2 662.38226 4.63 18.36 1323.75725

DGFNPADVEAGLYGSHLYVWDWQR

SELENBP1 selenium-binding protein 1 [Homo sapiens]

8991 NP_003935 2 1 16306550 N-Term(iTRAQ4plex) 0.967 1 0.813 1 0.776 1 0.954 1 0.978 1 1.203 1 1.261 1 33 6.72 0 4 647.06372 1.55 28.43 2585.23305

DGFVQDEGTMFPVGK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 12 1 45580688 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.764 1 0.918 1 0.681 1 0.742 1 0.783 1 0.854 1 1.151 1 26 0 2 465.31543 -3.09 32.38 929.62358

DGFVQDEGTMFPVGK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 8 1 45580688 N-Term(iTRAQ4plex); M10(Oxidation); K15(iTRAQ4plex)

1.228 2 9.2 0.781 2 7.7 1.016 2 3.4 1.301 2 11.1 1.172 2 7.9 1.5 2 15.7 1.153 2 4.6 4.04 1 3 659.35834 -9.63 67.45 1976.06046

DGHVILQLNSIPSSDFLCVR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 21 2 38016947 N-Term(iTRAQ4plex); C18(Methylthio)

1.475 1 1.062 1 1.454 1 1.369 1 1.588 1 1.494 1 1.092 1 2.78 2 2 652.8692 12.22 36.28 1304.73113

DGIHNVEGVAVDWMGDNLYWTDDGPK

LRP1 prolow-density lipoprotein receptor-related protein 1 precursor [Homo sapiens]

4035 NP_002323 2 1 126012562 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.409 1 0.932 1 1.228 1 1.318 1 1.494 1 1.603 1 1.216 1 3.66 1 3 1046.1516 -8.47 45.84 3136.44028

DGIVLGADTR PSMB7 proteasome subunit beta type-7 proprotein [Homo sapiens]

5695 NP_002790 1 1 4506203 N-Term(iTRAQ4plex) 1.041 1 0.79 1 0.883 1 1.118 1 0.98 1 1.24 1 1.109 1 34 2.88 0 2 529.36115 -6.95 24.96 1057.71501

DGLIPLEIR SELENBP1 selenium-binding protein 1 [Homo sapiens]

8991 NP_003935 1 1 16306550 N-Term(iTRAQ4plex) 0.973 1 0.867 1 0.831 1 0.959 1 0.985 1 1.137 1 1.185 1 2.87 0 2 635.29565 0.28 37.14 1269.58403

DGLIVPIFQER FUCA1 tissue alpha-L-fucosidase precursor [Homo sapiens]

2517 NP_000138 2 1 119360348 N-Term(iTRAQ4plex) 1.298 1 1.056 1 1.254 1 1.187 1 1.415 1 1.339 1 1.128 1 29 0 2 408.28204 -3.07 14.3 815.55681

DGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVR

MMP2 72 kDa type IV collagenase isoform b [Homo sapiens]

4313 NP_001121363 2 2 189217853 N-Term(iTRAQ4plex) 1.858 1 0.976 1 1.719 1 1.762 1 1.951 1 1.999 1 1.135 1 43 4.06 0 2 767.83466 0.69 41.08 1534.66203

DGNTLTYYR C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 13 1 4502511 N-Term(iTRAQ4plex) 0.525 1 1.074 1 0.52 1 0.484 1 0.569 1 0.529 1 1.094 1 5.33 2 6 780.24371 8.84 62.28 4676.4259

DGRPEIQLHNHWAQLTVGAGPR

SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 6 4 7382460 N-Term(iTRAQ4plex) 1.313 9 15.4 1.031 9 19.4 1.19 9 12.2 1.351 9 10.6 1.253 9 18 1.434 9 14.5 1.104 9 2.5 61 4.65 0 2 702.83923 -2.13 17.42 1404.66301

DGSPDVTTADIGANTPDATK

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 10 1 156616294 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

78 5.48 0 2 891.9339 -2.24 30.5 1782.86052

DGTDYIEIIPK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

84 5.65 0 2 861.91138 7.81 34.79 1722.80095

DGTWSNK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

2 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

74 6.05 0 4 1182.2513 6.35 53.3 3544.71206

DGVGDVCQDDFDADK COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 2 1 40217843 N-Term(iTRAQ4plex); C7(Methylthio); K15(iTRAQ4plex)

51 4.59 0 3 540.2887 -10.13 20.19 1618.85154

DGWHSWPIAHQWPQGPSAVDAAFSWEEK

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 292 1 11321561 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

42 9.02 0 4 1006.21 2.01 60.35 4021.81801

DGWQWFWSPSTFR APOC4 apolipoprotein C-IV precursor [Homo sapiens]

346 NP_001637 4 1 4502161 N-Term(iTRAQ4plex) 40 0 2 530.80658 2.74 14.51 1060.60588

DGWSAQPTCIK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 43 1 62739186 N-Term(iTRAQ4plex); C9(Methylthio); K11(iTRAQ4plex)

43 3.4 0 2 665.84375 -14.42 14.55 1330.68022

DGYLFQLLR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 17 1 4504489 N-Term(iTRAQ4plex) 69 4.89 0 3 503.93292 -0.68 39.49 1509.78105

DHAVDLIQK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

6 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

69 4.96 0 3 503.93292 -0.68 39.49 1525.78196

DHEELSLVASEAVR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 2 2 126273569 N-Term(iTRAQ4plex) 62 8.41 1 6 1616.7732 0.59 70.01 4848.31103

DHENELLNK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 3 3 14550407 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

53 6.49 0 4 1173.8143 7.35 59.85 4692.23549

DHLGFQVTWPDESK CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

13 1 256217721 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

53 0 2 629.82642 3.29 19.97 1258.64556

DIAILK CCDC121 coiled-coil domain-containing protein 121 isoform 3 [Homo sapiens]

79635 NP_078860 4 2 39979626 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

32 3.65 0 3 421.87109 2.86 20.37 1263.59873

DIALMK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 1 1 4503635 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

32 0 2 572.77429 3.81 17.9 1144.54131

DIAPTLTLYVGK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 23 3 4826762 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.409 2 13.5 0.985 2 19.7 1.388 2 5.4 1.409 2 14.2 1.409 2 12.9 1.431 2 33.2 1.015 2 18.4 4.12 0 3 852.07343 -7.44 46.92 2554.20572

DIASGLIGLLLICK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex); C13(Methylthio); K14(iTRAQ4plex)

2.073 3 26.7 0.895 3 1.1 1.893 3 30.8 2.132 3 52.2 2.021 3 5.8 2.277 3 25.1 1.097 3 3.9 118 6.66 0 3 810.9649 -4.78 23.62 1620.92704

DIASGLIGPLIICK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 147 1 4557485 N-Term(iTRAQ4plex); C13(Methylthio); K14(iTRAQ4plex)

4.073 2 1 1.022 2 8.7 3.928 2 6.4 3.845 2 2.3 4.31 2 4.4 4.219 2 4.3 1.097 2 2 86 5.66 0 3 741.39069 -5.97 15.92 1481.78199

DICEEQVNSLPGSITK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 54 1 115298678 N-Term(iTRAQ4plex); C3(Methylthio); K16(iTRAQ4plex)

3.754 2 11.1 0.973 2 10.9 3.464 2 18.5 3.559 2 7.5 3.948 2 14.8 4.056 2 3.9 1.14 2 3.7 46 4.52 0 2 781.9082 -1.71 42.9 1562.80913

DIDECDIVPDACK EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 9 1 86788015 N-Term(iTRAQ4plex); C5(Methylthio); C12(Methylthio); K13(iTRAQ4plex)

3.624 2 2.1 0.968 2 7 3.378 2 1.8 3.489 2 5.2 3.757 2 0.9 3.88 2 6 1.112 2 0.8 38 3.02 0 2 517.82654 -2.05 40.36 1034.6458

DIDECESGIHNCLPDFICQNTLGSFR

FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

16 4 34734066;34734062

N-Term(iTRAQ4plex); C5(Methylthio); C12(Methylthio); C18(Methylthio)

1.563 1 0.903 1 1.409 1 1.56 1 1.565 1 1.732 1 1.11 1 3.84 1 4 767.39459 -11.44 53.54 3066.55654

DIEHLTSLDFFR ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 2 3 91823602 N-Term(iTRAQ4plex) 1.583 2 1.9 0.97 2 6.1 1.381 2 4.8 1.423 2 1.3 1.738 2 4.9 1.791 2 1.1 1.259 2 0.1 3.87 2 4 665.3681 14.93 42.28 2658.45058

DIENQYETQITQIEHEVSSSGQEVQSSAK

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex); K29(iTRAQ4plex)

1.018 1 0.973 1 0.972 1 0.999 1 1.037 1 1.065 1 1.066 1 73 7.27 0 3 751.38464 0.64 52.22 2252.13938

DIFPNTVFADSNIDSVMAPDAFVCGR

F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex); C24(Methylthio)

1.528 1 0.911 1 1.367 1 1.5 1 1.554 1 1.705 1 1.136 1 54 4 0 2 644.37201 -1.71 45.83 1287.73674

DIFTGLIGPMK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 210 1 4557485 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.09 1 0.959 1 1.018 1 1.061 1 1.117 1 1.164 1 1.097 1 38 4.17 0 2 715.91016 0.41 50.19 1430.81304

DIFTGLIGPMK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 19 1 4557485 N-Term(iTRAQ4plex); M10(Oxidation); K11(iTRAQ4plex)

1.254 11 8.3 0.888 11 17.5 1.129 11 7.3 1.238 11 14.2 1.244 11 14.3 1.41 11 14.6 1.106 11 9.2 119 6.56 0 2 1113.5277 3.63 36.38 2226.04814

DIHSGLIGPLLICQK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 8 1 105990535 N-Term(iTRAQ4plex); C13(Methylthio); K15(iTRAQ4plex)

2.462 2 9.3 0.93 2 15 2.157 2 1.9 2.319 2 13.1 2.599 2 5.4 2.795 2 20.5 1.205 2 7.3 106 4.52 0 2 1012.4399 -3.85 40.04 2023.87248

DIILTVK FRMPD1 FERM and PDZ domain-containing protein 1 [Homo sapiens]

22844 NP_055722 5 1 239582741 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.624 45 10.4 0.926 45 15.5 1.474 45 13.5 1.632 45 10.7 1.65 45 10.5 1.811 45 11.4 1.117 45 6.5 106 8.75 0 3 768.08856 1.59 70.03 2302.25113

DILTIDIGR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 4 3 221316614 N-Term(iTRAQ4plex) 1.337 17 9.5 1.048 17 15.5 1.286 17 16.1 1.225 17 8.9 1.424 17 21.3 1.408 17 13.4 1.151 17 12 104 6.15 0 2 1012.4399 -3.85 40.04 2007.87529

DINYVNPVIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 14 2 38016947 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.278 9 7 1.086 9 21.7 1.193 9 19.9 1.222 9 6.9 1.303 9 18.3 1.363 9 17.2 1.151 9 5.1 99 5.56 0 3 1180.9181 -3.31 44.06 2360.82891

DIPQPHAEPWAFSLDLGLK SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 5 3 7382460 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.539 6 14.9 0.994 6 18 1.446 6 20.1 1.442 6 12 1.554 6 16.3 1.578 6 10 1.122 6 3.8 99 5.99 0 2 850.44666 -7.8 18.45 1699.88603

DIPTNSPELEETLTHTITK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

215 3 4504893;156231037

N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.341 33 6.4 0.991 33 9.1 1.252 33 9.7 1.278 33 7.7 1.402 33 6.5 1.456 33 9.5 1.13 33 5.3 95 5.69 0 2 1036.9194 -1.47 35.06 2072.82891

DISEVVTPR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 34 1 67782358 N-Term(iTRAQ4plex) 1.271 18 8.8 0.978 18 13.6 1.169 18 12.7 1.172 18 8 1.35 18 5.9 1.342 18 6.3 1.138 18 5.1 93 6.27 0 2 867.43555 -3.14 41.29 1733.87053

Page 8: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

DITTCFGGSLGIQYEDK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 4 1 4557389 N-Term(iTRAQ4plex); C5(Methylthio); K17(iTRAQ4plex)

1.578 45 12.5 1.016 45 16.3 1.482 45 16.9 1.507 45 16.7 1.644 45 16.5 1.722 45 10.7 1.107 45 12.8 91 9.7 0 3 962.49817 1.83 81.14 2885.47995

DIYVDLDMK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.226 26 14.4 0.965 26 10.1 1.214 26 15.4 1.21 26 19.1 1.306 26 17.3 1.296 26 12.2 1.091 26 6.9 86 6.55 0 3 1102.0045 -4.31 47.86 2203.0131

DKAQNLYQELLTQEGQASFQGLK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K23(iTRAQ4plex)

1.535 2 10.2 0.789 2 38.9 1.257 2 24.6 1.594 2 13.4 1.509 2 29.5 1.914 2 8.7 1.201 2 4.7 82 4.37 0 2 1036.9194 -1.47 35.06 2088.82768

DKATFGCHDGYSLDGPEEIECTK

APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 2 1 153266841 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C7(Methylthio); C21(Methylthio); K23(iTRAQ4plex)

2.054 9 7.4 0.971 9 24.7 1.803 9 15.6 2.101 9 14 2.099 9 18.4 2.365 9 9.4 1.083 9 7.5 82 5.61 0 3 1102.0045 -4.31 47.86 2219.00351

DKDQEVLLQTFLDDASPGDK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K20(iTRAQ4plex)

1.525 18 11.7 1.12 18 9.5 1.471 18 17.1 1.402 18 12.7 1.673 18 11 1.582 18 2.6 1.135 18 9.3 76 5.66 0 2 864.00671 -1.93 43.02 1727.00615

DKDQEVLLQTFLDDASPGDKR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K20(iTRAQ4plex)

1.334 5 5.2 0.949 5 12.5 1.218 5 11.2 1.261 5 27.2 1.314 5 2.6 1.4 5 15.1 1.11 5 13.3 66 8.56 1 3 1229.6794 1.23 55.19 2458.3555

DKEALMEEILK BICD2 protein bicaudal D homolog 2 isoform 2 [Homo sapiens]

23299 NP_056065 1 4 21735417 N-Term(iTRAQ4plex); K2(iTRAQ4plex); M6(Oxidation); K11(iTRAQ4plex)

1.271 36 10.5 0.978 36 17.3 1.168 36 13.5 1.226 36 17.9 1.312 36 13.5 1.356 36 9.5 1.121 36 11.1 65 9.37 0 3 1410.2058 -0.68 63.81 2819.40434

DKIGVELTGR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.473 21 5 0.94 21 16.7 1.329 21 17.3 1.368 21 8.4 1.52 21 15.5 1.555 21 9.8 1.141 21 3.5 64 4.53 0 2 740.92316 -0.83 38.8 1480.84001

DKLAACLEGNCAEGLGTNYR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 5 1 4503635 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C6(Methylthio); C11(Methylthio)

1.295 12 6.4 1.034 12 11.8 1.208 12 10.2 1.188 12 6.8 1.407 12 9.8 1.364 12 5.7 1.148 12 3.9 55 3.99 0 2 718.35583 6.38 19.65 1435.70098

DKVNSFFSTFK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 6 1 71773110 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex)

1.075 10 9.3 0.983 10 2.3 1.019 10 17.3 1.008 10 7 1.119 10 18.5 1.137 10 6.6 1.109 10 1.6 54 4.03 0 2 691.289 -0.86 34.2 1381.57073

DKYILQGVTSWGLGCARPNKPGVYVR

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 4 1 4505881 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C15(Methylthio); K20(iTRAQ4plex)

1.163 2 19.2 0.758 2 37.2 0.977 2 48.7 1.29 2 10.1 1.076 2 24.3 1.42 2 12.1 1.101 2 22.4 51 4.8 0 3 836.9425 1.94 14.88 1672.87534

DLAPTSK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 2 4 189181722 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.118 13 20.5 0.92 13 22.6 0.927 13 24.8 1.138 13 17.8 1.084 13 21.3 1.295 13 19.3 1.159 13 2.7 43 0 2 538.78333 4.51 29.24 1076.55474

DLATVYVDVLK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 3 1 4557321 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.155 3 0.1 1.074 3 21.3 1.085 3 10.7 1.01 3 2.8 1.218 3 6.1 1.134 3 4.9 1.123 3 2.1 35 0 2 484.80707 5.11 17.89 968.60686

DLDMFINASK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 8 3 21450863 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.016 3 14.3 1.166 3 2 1.026 3 18.2 0.868 3 1.9 1.19 3 8.9 1.065 3 2.6 1.16 3 9.3 35 0 2 591.81842 3.56 23.44 1182.62956

DLDSQTMMVLVNYIFFK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 292 1 50659080 N-Term(iTRAQ4plex); M8(Oxidation); K17(iTRAQ4plex)

1.233 1 0.922 1 1.087 1 1.179 1 1.282 1 1.39 1 1.18 1 34 0 2 503.29501 0.84 11.55 1005.58275

DLDSQTMMVLVNYIFFK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 49 1 50659080 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

2.428 1 0.732 1 2.013 1 2.751 1 2.191 1 2.994 1 1.089 1 33 8.22 0 4 962.49817 1.83 81.14 2901.46718

DLDSQTMMVLVNYIFFK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 61 1 50659080 N-Term(iTRAQ4plex); M7(Oxidation); M8(Oxidation); K17(iTRAQ4plex)

0.968 1 0.691 1 0.768 1 1.112 1 0.868 1 1.257 1 1.13 1 31 0 2 529.30408 5.14 16.18 1057.60088

DLDVFARTQEVK MTHFSD methenyltetrahydrofolate synthase domain-containing protein isoform 5 [Homo sapiens]

64779 NP_001152852 1 3 226823326 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.259 1 0.85 1 1.063 1 1.251 1 1.267 1 1.491 1 1.192 1 21 0 2 461.71622 0.9 30.61 922.42516

DLEEPINFR IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 1 3 19882209 N-Term(iTRAQ4plex) 1.517 6 5.3 1.018 6 10.3 1.415 6 7 1.436 6 10.1 1.508 6 3.8 1.598 6 5.9 1.112 6 2.3 3.24 0 2 575.83356 0.84 23.53 1150.66106

DLEIEVVLFHPNYNINGK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 25 1 67782358 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

0.978 6 9.5 0.954 6 3.1 0.956 6 9.5 0.967 6 4.9 1.007 6 12.5 1.056 6 9.5 1.085 6 3.1 2.93 0 2 627.30322 -3.87 29.57 1253.59917

DLEVVAATPTSLLISWDAPAVTVR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

22 5 47132549;16933542

N-Term(iTRAQ4plex) 0.76 1 0.937 1 0.69 1 0.736 1 0.782 1 0.835 1 1.134 1 98 4.88 0 2 784.94916 -3.21 38.51 1568.89104

DLFIGDVIHNAGPHR B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Homo sapiens]

10678 NP_006568 2 1 9845238 N-Term(iTRAQ4plex) 1.124 3 3.9 0.82 3 11.9 0.877 3 11.6 0.99 3 4.7 1.152 3 19.8 1.144 3 8.8 1.194 3 13.6 80 4.7 0 2 907.4917 -3.6 58.24 1813.97612

DLGAPEGIGSGSKAGFRDGLGGSEEMR

IGFN1 immunoglobulin-like and fibronectin type III domain-containing protein 1 [Homo sapiens]

91156 NP_001158058 2 1 257196151 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.115 2 2 0.965 2 6.2 1.034 2 4.5 1.072 2 1.7 1.156 2 5.6 1.199 2 0.7 1.118 2 1 69 4.99 0 3 988.56616 -2.86 56.75 1976.1359

DLGQCDR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 7 1 105990532 N-Term(iTRAQ4plex); C5(Methylthio)

0.808 1 0.841 1 0.727 1 0.864 1 0.762 1 0.906 1 1.048 1 66 9.03 0 3 745.08923 -2.34 58.48 2233.25315

DLHFLEELQLGHNR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 8 2 4826772 N-Term(iTRAQ4plex) 0.902 2 21.4 0.962 2 1.1 0.813 2 22.5 0.845 2 23.6 0.957 2 19.5 0.995 2 20.6 1.177 2 2.9 63 4.24 0 2 662.35571 -1.34 23.08 1323.70049

DLHLSDVFLK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 8 1 169636415 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.876 2 3.8 0.948 2 4.5 0.765 2 1.3 0.807 2 5.8 0.939 2 11.9 0.991 2 7.3 1.228 2 13.2 58 4.06 0 2 808.01746 -0.52 59.11 1615.02764

DLKVEDIPLAR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K3(iTRAQ4plex)

1.112 1 0.845 1 1.001 1 1.185 1 1.05 1 1.243 1 1.049 1 54 6.51 0 3 916.14624 4.09 36.18 2746.42417

DLLGIYEK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 2 1 29171717 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.885 1 0.859 1 0.757 1 0.881 1 0.887 1 1.033 1 1.172 1 49 4.16 0 2 849.96307 1.78 62.81 1698.91887

DLLLPQPDLR LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 18 1 16418467 N-Term(iTRAQ4plex) 0.922 2 0.1 1.024 2 5.6 0.886 2 5.1 0.865 2 0.5 0.98 2 0.6 0.958 2 5.1 1.107 2 4.6 41 3.66 0 2 648.30261 -0.41 22 1295.59795

DLLPASLGSYYR PTPRG receptor-type tyrosine-protein phosphatase gamma [Homo sapiens]

5793 NP_002832 2 1 194097398 N-Term(iTRAQ4plex) 2.218 2 29.2 0.871 2 16.9 1.993 2 37.9 2.288 2 20 2.163 2 37.5 2.483 2 19.7 1.085 2 0.4 21 0 2 428.78809 -5.59 39.46 856.57189

DLLQTVEDQYK ANGPTL3 angiopoietin-related protein 3 precursor [Homo sapiens]

27329 NP_055310 2 1 7656888 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.957 10 34.9 1.038 10 52.3 0.895 10 53.5 0.909 10 36.6 1.029 10 35.9 0.961 10 34.9 1.237 10 27.3 162 8.48 0 3 1264.5332 2.02 13.22 2528.05625

DLLYIGK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 157 1 67782358 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.518 5 0.7 0.932 5 2.8 0.469 5 4.8 0.502 5 4.7 0.548 5 0.6 0.592 5 1.7 1.188 5 1.8 146 7.79 0 2 949.90125 -4.17 26.83 1898.79521

DLMVLNDVYR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 N-Term(iTRAQ4plex) 0.78 2 14.7 0.982 2 16.8 0.702 2 6.9 0.715 2 23.8 0.847 2 6 0.862 2 23 1.206 2 0.8 114 7.28 0 2 901.45007 -1.18 36.1 1801.89495

DLQFSEIR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 1 2 188528648 N-Term(iTRAQ4plex) 0.599 3 3.5 0.968 3 4.2 0.547 3 6.6 0.566 3 2.3 0.632 3 4.6 0.652 3 0.4 1.154 3 1.9 98 5.28 0 2 930.97998 -0.3 23.85 1860.95537

DLQFVEVTDVK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

41 5 47132549;16933542

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.699 13 9.8 0.994 13 21.7 0.637 13 31.5 0.631 13 9.6 0.779 13 18.5 0.724 13 8.1 1.163 13 7.5 92 5.87 0 2 823.4447 -10.85 36.24 1645.88213

DLSEAHFAPC IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 3 2 4826772 N-Term(iTRAQ4plex); C10(Methylthio)

0.739 6 22.9 1.108 6 16.5 0.724 6 31.6 0.648 6 12.3 0.846 6 28.3 0.759 6 11.9 1.168 6 1.8 85 6.37 0 2 836.44989 -1.19 37.9 1671.88713

DLSISIDK GPR116 probable G-protein coupled receptor 116 precursor [Homo sapiens]

221395 NP_056049 1 1 148719673 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.554 2 30.6 0.865 2 6.3 0.541 2 34.9 0.625 2 41.9 0.492 2 19.7 0.569 2 26.2 0.911 2 14.5 85 8.35 0 3 1349.6246 2.51 24.2 2698.23484

DLSPDDPQVQK CST6 cystatin-M precursor [Homo sapiens]

1474 NP_001314 XP_943896

4 1 4503113 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.801 8 13.7 1.013 8 24.4 0.604 8 20.5 0.684 8 13.1 0.835 8 21.6 0.912 8 19.2 1.37 8 5.7 81 5.9 0 2 795.96094 -2.97 52 1590.91716

DLTALSNMLPK ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 2 1 157266300 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.664 4 6.4 1.033 4 3 0.615 4 6.9 0.595 4 4.8 0.722 4 8.8 0.707 4 9.2 1.236 4 13.2 70 4.85 0 3 810.42767 -1.81 45.44 1619.84781

DLTDYLMK ACTB;ACTG2

actin, cytoplasmic 1 [Homo sapiens];actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

60;72 NP_001092;NP_001606

4 8 4501885;4501889

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.653 1 0.859 1 0.58 1 0.675 1 0.634 1 0.738 1 1.094 1 69 8.68 0 3 1349.6246 2.51 24.2 2714.21775

DLTGFPGPLNDQDDEDCINR

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 N-Term(iTRAQ4plex); C17(Methylthio)

0.718 6 2.8 1.164 6 7.3 0.738 6 7.2 0.646 6 7.5 0.85 6 6.3 0.752 6 10.5 1.187 6 0.7 68 5.27 0 2 777.42755 4.14 19.46 1553.81731

DLTSLGHNENQQGSFSSQGGSSFSVPIFYSSK

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 2 1 169636415 N-Term(iTRAQ4plex); K32(iTRAQ4plex)

0.708 7 22 0.914 7 1.9 0.547 7 29.8 0.605 7 14 0.8 7 30.7 0.746 7 27.2 1.26 7 19.7 64 6.01 0 3 1069.5424 -0.62 55.12 2138.08005

DLVGELGTALR FUCA1 tissue alpha-L-fucosidase precursor [Homo sapiens]

2517 NP_000138 2 1 119360348 N-Term(iTRAQ4plex) 2.101 1 3.528 1 3.398 1 0.963 1 6.116 1 1.733 1 1.8 1 57 7 1 3 643.02716 1.51 38.14 1927.06693

DLWVNIDQMEK PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.77 6 7.9 1.059 6 5.7 0.738 6 3.6 0.673 6 6.6 0.868 6 11.6 0.795 6 9.2 1.199 6 4.2 54 0 2 488.7995 0.95 17.95 976.59807

DLYANTVLSGGTTMYPGIADR

ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 2 2 4501885 N-Term(iTRAQ4plex) 0.681 4 4.3 1.028 4 5.3 0.613 4 8.3 0.598 4 7.9 0.79 4 10.3 0.748 4 1.2 1.25 4 6.7 54 4.19 0 2 662.35651 2.42 33.94 1323.70329

DLYSGLIGPLIVCR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 156 1 4557485 N-Term(iTRAQ4plex); C13(Methylthio)

0.746 7 12.7 1.045 7 9.6 0.669 7 15.8 0.645 7 12.8 0.832 7 16.6 0.808 7 11.8 1.25 7 0.8 51 5.04 0 2 711.41071 1.43 41.21 1421.81413

DMALTAFVLISLQEAK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 77 1 115298678 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.775 5 3.9 0.987 5 8.1 0.68 5 5.5 0.728 5 11.3 0.82 5 3.2 0.877 5 10 1.205 5 0.8 48 4.36 0 2 722.8147 -6.68 37.37 1444.63054

DMELSFAVQRGMDKVCGICMEVVYEK

MKRN3 probable E3 ubiquitin-protein ligase makorin-3 [Homo sapiens]

7681 NP_005655 1 1 5032243 N-Term(iTRAQ4plex); M2(Oxidation); M12(Oxidation); K14(iTRAQ4plex); C16(Methylthio); C19(Methylthio); K26(iTRAQ4plex)

0.791 4 16.7 0.917 4 1.6 0.695 4 18.3 0.747 4 14.3 0.825 4 17.6 0.887 4 13.9 1.187 4 1.5 48 3.59 0 2 722.8147 -6.68 37.37 1460.62712

DMENLEDVFYQMIDESQSLSLCGMVWEHR

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 2 1 67782358 N-Term(iTRAQ4plex); M12(Oxidation); C22(Methylthio); M24(Oxidation)

0.687 1 0.852 1 0.56 1 0.657 1 0.712 1 0.836 1 1.272 1 48 0 2 652.32465 -1.72 12.2 1303.64202

DMPASEDLQDLQK SEPP1 selenoprotein P isoform 1 precursor [Homo sapiens]

6414 NP_005401 6 2 62530391 N-Term(iTRAQ4plex); M2(Oxidation); K13(iTRAQ4plex)

0.864 2 7.9 1.031 2 22 0.771 2 23.1 0.748 2 1.1 0.988 2 16 0.958 2 5.8 1.281 2 6.9 46 4.21 0 2 677.36029 -8.84 15.97 1353.7133

DMPASEDLQDLQK SEPP1 selenoprotein P isoform 1 precursor [Homo sapiens]

6414 NP_005401 8 2 62530391 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.797 1 1.1 1 0.762 1 0.693 1 0.912 1 0.829 1 1.197 1 38 3.65 0 2 589.31708 7.42 25.95 1177.62688

DMTEVISSLENANYK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 12 2 14550407 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.565 1 2.273 1 3.248 1 1.429 1 5.148 1 2.265 1 1.585 1 32 4.24 2 4 654.86438 1.49 51.24 2616.43569

DMVEYK AFM afamin precursor [Homo sapiens] 173 NP_001124 4 1 4501987 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.913 1 1.018 1 0.745 1 0.732 1 1.096 1 1.077 1 1.471 1 22 0 2 722.8147 -6.68 37.37 1476.62114

DMYSFLEDMGLK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); M2(Oxidation); K12(iTRAQ4plex)

1.664 2 9.4 3.076 2 33.6 2.575 2 38.5 0.837 2 4.4 4.239 2 33 1.378 2 0.6 1.646 2 5 6.31 1 3 765.39764 -0.66 47.82 2294.17838

DMYSFLEDMGLK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 14 1 66932947 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.697 1 0.929 1 0.567 1 0.61 1 0.778 1 0.837 1 1.372 1 94 5.86 0 2 777.91772 2.39 32.81 1554.82817

DNCCILDER FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); C3(Methylthio); C4(Methylthio)

0.844 3 14.5 1.054 3 4.2 0.781 3 17.8 0.741 3 13.5 0.952 3 15.7 0.903 3 11.5 1.219 3 2.1 74 4.6 0 2 763.88843 -4.44 39.06 1526.77068

DNCPFHYNPAQYDYDR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 2 1 40317626 N-Term(iTRAQ4plex); C3(Methylthio)

1.03 4 3.8 0.955 4 17.8 0.873 4 3.5 0.951 4 9.3 1.111 4 9.2 1.175 4 7.1 1.239 4 7.6 60 5.56 0 2 857.44238 -1.15 49.58 1713.87749

DNCPFHYNPAQYDYDRDDVGDR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 3 1 40317626 N-Term(iTRAQ4plex); C3(Methylthio)

0.804 2 9.6 0.876 2 5.3 0.697 2 8.2 0.796 2 13.5 0.811 2 6.2 0.926 2 11.5 1.163 2 2 51 4.57 0 3 716.41754 -1.37 37.43 1431.83072

DNCQYVYNVDQR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 9 1 40317626 N-Term(iTRAQ4plex); C3(Methylthio)

0.749 3 17.2 1.045 3 11.1 0.66 3 10.9 0.719 3 5.1 0.805 3 10 0.848 3 14.8 1.303 3 1 48 3.39 0 2 628.33954 -3.6 33.69 1255.68669

DNEDFQESNR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 17 1 4557485 N-Term(iTRAQ4plex) 0.825 2 8.3 0.952 2 10.6 0.679 2 11.6 0.713 2 1 0.933 2 14.9 0.98 2 4.3 1.373 2 3.3 44 3.4 0 2 669.84052 -2.46 16.81 1338.67595

DNEETGFGSGTR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 2 1 157266300 N-Term(iTRAQ4plex) 0.728 1 0.955 1 0.594 1 0.622 1 0.829 1 0.868 1 1.396 1 39 3.54 0 2 619.32269 7.07 25.96 1237.63811

DNELLVYK APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 34 1 4502133 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

63 4.48 0 2 746.41772 -8.59 23.69 1491.82817

DNENVVNEYSSELEK FGB fibrinogen beta chain isoform 1 preproprotein [Homo sapiens]

2244 NP_005132 2 2 70906435 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

58 4.31 0 2 1018.0446 4.36 67.77 2035.08183

DNEQHVFK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 8 1 67782358 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

4.5 1 3 731.06305 0.23 52.02 2191.17459

DNHLLGTFDLTGIPPAPR HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 1 1 16507237 N-Term(iTRAQ4plex) 83 5.74 0 2 809.46594 -3.47 51.02 1617.92986

DNPMYYCNK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 6 3 21450863 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

49 4.79 0 2 704.40179 -0.09 48.35 1407.79631

DNPMYYCNK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 3 21450863 N-Term(iTRAQ4plex); M4(Oxidation); C7(Methylthio); K9(iTRAQ4plex)

1.065 1 0.915 1 0.957 1 1.046 1 1.082 1 1.183 1 1.131 1 4.76 0 3 662.69 -0.26 34.04 1986.05545

DNSKNSLYLQMNSLRAEDTALYYCAK

LOC100653084

PREDICTED: hypothetical protein LOC100653084 [Homo sapiens]

100653084 XP_003403714 1 1 341913933 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C24(Methylthio); K26(iTRAQ4plex)

1.726 1 0.997 1 1.639 1 1.644 1 1.807 1 1.812 1 1.102 1 32 0 2 459.81458 -0.84 24.18 918.62187

DNVDDPTGNFR LMAN2 vesicular integral-membrane protein VIP36 precursor [Homo sapiens]

10960 NP_006807 1 1 5803023 N-Term(iTRAQ4plex) 1.244 1 1.006 1 1.14 1 1.132 1 1.356 1 1.347 1 1.19 1 68 5.37 0 2 895.93298 -6.09 34.19 1790.85869

DNVEMDTFQIECLK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

7 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C12(Methylthio); K14(iTRAQ4plex)

1.325 1 0.891 1 1.199 1 1.345 1 1.308 1 1.467 1 1.091 1 46 5.58 0 3 543.95221 -2.77 19.87 1629.84208

DNVFDGLVR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 20 1 105990532 N-Term(iTRAQ4plex) 1.167 1 1.018 1 1.1 1 1.081 1 1.254 1 1.232 1 1.14 1 39 0 2 540.81122 -1.71 27.67 1080.61516

DPAGHFHQVWYDNPQSISLK

CTBS di-N-acetylchitobiase precursor [Homo sapiens]

1486 NP_004379 2 1 4758092 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.142 1 0.99 1 1.055 1 1.065 1 1.217 1 1.23 1 1.154 1 3.79 0 3 728.6665 1.41 29.6 2183.98496

DPAGPPDGGPDTEPR SLC38A10 putative sodium-coupled neutral amino acid transporter 10 isoform a [Homo sapiens]

124565 NP_001033073 2 1 83921602 N-Term(iTRAQ4plex) 0.832 1 0.853 1 0.666 1 0.78 1 0.876 1 1.026 1 1.315 1 87 7.62 0 3 693.74097 1.93 62.4 2079.20835

DPCHGVTCRPQETCK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex); C3(Methylthio); C8(Methylthio); C14(Methylthio); K15(iTRAQ4plex)

1.307 2 16.6 1.201 2 3 1.393 2 17 1.159 2 14 1.483 2 19.5 1.235 2 16.4 1.065 2 2.4 62 5.48 0 3 672.4021 -0.28 75.2 2015.19175

DPEIHLSGPLEAGKPITVK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 3 3 4507875 N-Term(iTRAQ4plex); K14(iTRAQ4plex); K19(iTRAQ4plex)

2.839 1 0.789 1 2.374 1 3.008 1 2.706 1 3.427 1 1.14 1 43 4.78 0 2 749.4306 2.21 32.7 1497.85393

DPPELHAAASSESTGFGEERESIL

KIDINS220 kinase D-interacting substrate of 220 kDa [Homo sapiens]

57498 NP_065789 XP_291015

1 1 55741641 N-Term(iTRAQ4plex) 1.757 1 0.718 1 1.515 1 2.11 1 1.503 1 2.093 1 0.992 1 3.47 2 3 768.42633 17.48 66.99 2303.26444

DPPQYPVVPVHLDR RNASE2 non-secretory ribonuclease precursor [Homo sapiens]

6036 NP_002925 1 1 4506549 N-Term(iTRAQ4plex) 1.187 1 0.948 1 1.098 1 1.159 1 1.214 1 1.281 1 1.106 1 74 4.28 0 2 835.34991 -1.25 17.82 1669.69255

DPPSDLLLLK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.156 1 0.517 1 0.931 1 1.803 1 0.823 1 1.592 1 0.883 1 80 6.63 0 3 1064.505 0.66 54.1 3191.50046

DPSASPGDAGEQAIR VCL vinculin isoform VCL [Homo sapiens]

7414 NP_003364 2 2 4507877 N-Term(iTRAQ4plex) 1.184 1 0.773 1 1.001 1 1.296 1 1.097 1 1.419 1 1.095 1 67 3.34 0 2 552.81049 0.63 28.74 1104.6137

DPSLGAQFR ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 3 preproprotein [Homo sapiens]

11093 NP_620595 2 3 21265043 N-Term(iTRAQ4plex) 1.286 1 0.863 1 1.099 1 1.273 1 1.298 1 1.503 1 1.181 1 56 4.34 0 2 691.41772 -0.19 36.24 1381.82817

DPTFIPAPIQAK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 34 1 4557287 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.202 1 1.042 1 1.13 1 1.084 1 1.326 1 1.272 1 1.174 1 38 4.3 0 3 571.0058 0.27 43.14 1711.00284

DPTPEQTHR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 21 1 115583663 N-Term(iTRAQ4plex) 1.168 1 1.002 1 1.094 1 1.091 1 1.246 1 1.243 1 1.139 1 5.44 0 3 683.68414 0 42.08 2049.03788

DPVASSLSPYFGTK MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 2 2 19923761 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.006 1 0.96 1 0.948 1 0.987 1 1.023 1 1.066 1 1.079 1 3.53 0 3 718.69983 -2.02 31.4 2154.08493

DPVASTSNLDMDFR PLTP phospholipid transfer protein isoform c precursor [Homo sapiens]

5360 NP_001229849 2 4 339275807 N-Term(iTRAQ4plex) 0.977 1 0.861 1 0.826 1 0.959 1 0.992 1 1.152 1 1.202 1 84 7.24 0 3 621.00677 -1.69 51.88 1861.00577

DQCDK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 1 1 355594753 N-Term(iTRAQ4plex); C3(Methylthio); K5(iTRAQ4plex)

1.229 2 0.7 1.004 2 10.6 1.195 2 7.7 1.191 2 2.9 1.269 2 1.6 1.264 2 8.9 1.061 2 6 80 5.66 0 3 641.71173 -0.64 63.52 1923.12064

DQCEDIDECQHR LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 2 5 261337173 N-Term(iTRAQ4plex); C3(Methylthio); C9(Methylthio)

1.492 4 9.2 1.223 4 11.8 1.497 4 24.6 1.159 4 16.7 1.746 4 7.6 1.46 4 8.5 1.237 4 9.9 75 6.13 0 3 670.37909 0.22 75.14 2009.12271

DQCIVDDITYNVNDTFHK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 6 47132549;16933542

N-Term(iTRAQ4plex); C3(Methylthio); K18(iTRAQ4plex)

0.814 2 2.6 0.914 2 4.3 0.751 2 4.6 0.821 2 0.3 0.807 2 4.7 0.883 2 0.4 1.075 2 0.1 74 5.03 0 2 819.80957 -1.15 21.81 1638.61308

DQFNLIVFSTEATQWRPSLVPASAENVNK

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

75 2 31542984;262050538

N-Term(iTRAQ4plex); K29(iTRAQ4plex)

1.333 1 0.829 1 1.152 1 1.389 1 1.287 1 1.551 1 1.117 1 68 4.65 0 2 1031.4294 -0.2 34.74 2061.85161

DQLPYICQFGIV CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 1 1 156627579 N-Term(iTRAQ4plex); C7(Methylthio)

1.014 1 0.939 1 0.93 1 0.991 1 1.035 1 1.102 1 1.112 1 60 3.79 0 2 623.25952 -2.04 22.75 1245.51177

DQVLVSCDTGYK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

4 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C7(Methylthio); K12(iTRAQ4plex)

1.066 1 0.749 1 0.869 1 1.161 1 0.995 1 1.329 1 1.145 1 59 5.22 0 3 612.63251 -3.89 33.46 1835.88297

DQVNTFDNIFIAPVGISTAMGMISLGLK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 6 1 73858566 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.092 1 0.878 1 1.003 1 1.142 1 1.049 1 1.194 1 1.046 1 56 4.34 0 2 927.36414 0.75 22.65 1853.72099

DQVNTFDNIFIAPVGISTAMGMISLGLK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 20 1 73858566 N-Term(iTRAQ4plex); M22(Oxidation); K28(iTRAQ4plex)

1.173 1 1.039 1 1.143 1 1.099 1 1.25 1 1.202 1 1.094 1 53 4.51 0 2 676.34021 0.63 21.14 1351.67314

DRDGNTLTYYR C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 2 1 4502511 N-Term(iTRAQ4plex) 1.184 1 1.022 1 1.085 1 1.062 1 1.31 1 1.282 1 1.208 1 51 2.89 0 2 905.93274 -0.16 42.73 1810.8582

DRFSAEDEALSNIAREAEAR LRRFIP2 leucine-rich repeat flightless-interacting protein 2 isoform 2 [Homo sapiens]

9209 NP_060194 1 3 8923224 N-Term(iTRAQ4plex) 1.25 1 0.935 1 1.175 1 1.257 1 1.244 1 1.33 1 1.059 1 50 3.93 0 2 687.38458 -2.87 38.08 1373.76189

DSAIGFSR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 1 2 312433998 N-Term(iTRAQ4plex) 1.143 1 0.993 1 0.988 1 0.995 1 1.289 1 1.298 1 1.304 1 47 5.22 0 3 866.82324 -1.61 33.85 2598.45517

DSALSWEYCR HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 2 1 4504383 N-Term(iTRAQ4plex); C9(Methylthio)

1.113 1 0.891 1 1 1 1.123 1 1.105 1 1.24 1 1.104 1 35 3.06 0 2 652.29852 0.46 31.82 1303.58977

DSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMK

F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 5 1 4503649 N-Term(iTRAQ4plex); C3(Methylthio); C31(Methylthio); M33(Oxidation); K34(iTRAQ4plex)

1.107 1 1.053 1 1.152 1 1.094 1 1.121 1 1.065 1 0.973 1 33 5.05 0 3 604.29675 -4.64 24.96 1810.87571

Page 9: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

DSCTLPASAEK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 9 1 45580688 N-Term(iTRAQ4plex); C3(Methylthio); K11(iTRAQ4plex)

0.21 4 9.6 0.935 4 5.3 0.186 4 19.9 0.199 4 8.6 0.22 4 11 0.225 4 7.5 1.182 4 7.4 3.44 0 2 806.93787 -10.82 39.69 1612.86846

DSCVGSLVVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 20 1 115298678 N-Term(iTRAQ4plex); C3(Methylthio); K10(iTRAQ4plex)

1.361 1 1.013 1 1.298 1 1.281 1 1.442 1 1.423 1 1.111 1 3.42 1 3 893.12781 -3.42 39.79 2677.36887

DSDGDGIGDACDNCPQK COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 3 1 40217843 N-Term(iTRAQ4plex); C11(Methylthio); C14(Methylthio); K17(iTRAQ4plex)

1.164 1 0.714 1 0.942 1 1.319 1 1.053 1 1.474 1 1.118 1 3.52 0 3 674.00537 -12.41 33.9 2020.00156

DSDLLSPSDFK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 4 1 21264357 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.169 1 0.777 1 2.06 1 2.651 1 0.016 1 0.021 1 3.86 0 4 916.52277 2.17 80.97 3663.06923

DSEITFIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 16 2 38016947 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.54 3 17.5 0.995 3 11.1 1.412 3 16.8 1.42 3 28.3 1.659 3 7.8 1.668 3 19 1.175 3 9 93 6.63 1 3 1029.5465 -10.34 17.7 2058.08457

DSFDIIK FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 3 1 34734066 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.453 8 7 0.87 8 9.1 1.297 8 9 1.498 8 9.1 1.498 8 3 1.718 8 1.3 1.129 8 10.5 90 6.84 0 3 1349.1813 1.45 61.44 2697.36289

DSFHLDEQFTVPVEMMQAR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 37 2 115583663 N-Term(iTRAQ4plex) 1.469 6 5.7 0.934 6 3.9 1.325 6 13.1 1.44 6 10.3 1.507 6 13.2 1.568 6 7.4 1.121 6 12.6 76 5.4 0 3 520.26086 -3.8 36.89 1558.77683

DSFHLDEQFTVPVEMMQAR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 23 2 115583663 N-Term(iTRAQ4plex); M16(Oxidation)

1.554 1 0.942 1 1.474 1 1.565 1 1.543 1 1.638 1 1.047 1 71 5.18 0 2 849.93903 -4.23 26.88 1698.87078

DSFHLDEQFTVPVEMMQAR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 11 2 115583663 N-Term(iTRAQ4plex); M15(Oxidation); M16(Oxidation)

1.486 3 1.5 0.989 3 5.6 1.377 3 1.1 1.392 3 9.3 1.548 3 5.5 1.565 3 5.9 1.132 3 4.8 71 6.14 0 3 957.94006 1.09 23.63 1914.8732

DSFSNEK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 6 3 21450863 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.628 2 15.3 0.87 2 13.2 1.459 2 14.3 1.676 2 27.8 1.587 2 4.5 1.824 2 17.8 1.088 2 9.7 66 5.46 0 2 756.89362 -1.04 41.83 1512.77995

DSGEDPATCAFQR SPP2 secreted phosphoprotein 24 precursor [Homo sapiens]

6694 NP_008875 2 1 5902118 N-Term(iTRAQ4plex); C9(Methylthio)

1.828 1 1.008 1 1.69 1 1.677 1 1.981 1 1.966 1 1.172 1 58 3.09 0 2 555.82703 6.31 16.19 1110.64678

DSHSLTTNIMEILR FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex) 1.479 1 0.958 1 1.261 1 1.317 1 1.633 1 1.706 1 1.295 1 53 5.93 0 3 1349.1813 1.45 61.44 2713.35459

DSITTWEILAVSMSDK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 94 1 115298678 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.469 10 3.4 1.001 10 8.4 1.41 10 7.8 1.396 10 4.2 1.577 10 11.3 1.56 10 5.2 1.119 10 1.7 49 2.77 0 2 592.36798 -3.57 28.67 1183.72917

DSITTWEILAVSMSDK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); M13(Oxidation); K16(iTRAQ4plex)

1.321 2 4.4 0.901 2 23.7 1.188 2 18.1 1.318 2 5.4 1.331 2 13.4 1.477 2 10.1 1.12 2 4.6 46 0 2 454.27634 -3.09 19.54 907.5454

DSLDQLVGGVPVTLNAQTIDVNQETSDLDPSK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 3 1 38016947 N-Term(iTRAQ4plex); K32(iTRAQ4plex)

1.276 4 3.3 0.858 4 14.7 1.102 4 3.6 1.277 4 12.1 1.276 4 4 1.488 4 10.7 1.165 4 2.5 45 7.37 0 3 1075.2042 1.3 46.27 3223.59812

DSLEFR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 1 1 50659080 N-Term(iTRAQ4plex) 1.44 5 4.9 0.91 5 3.4 1.331 5 2.5 1.469 5 5.5 1.478 5 2.4 1.624 5 4.7 1.128 5 2 35 3.18 0 2 586.82349 -3 44.09 1172.63933

DSLYPYLEDIPDPEVNWIPCNNR

VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 1 1 223633991 N-Term(iTRAQ4plex); C20(Methylthio)

1.291 1 0.767 1 1.07 1 1.395 1 1.211 1 1.579 1 1.131 1 30 0 3 377.21411 -0.03 12.76 1129.62778

DSMIWDCTCIGAGR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

49 6 47132549;16933542

N-Term(iTRAQ4plex); C7(Methylthio); C9(Methylthio)

1.132 1 0.847 1 1.042 1 1.231 1 1.049 1 1.239 1 1.006 1 7.28 0 4 649.31921 -2.64 33.86 2594.25503

DSMIWDCTCIGAGR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

4 6 47132549;16933542

N-Term(iTRAQ4plex); M3(Oxidation); C7(Methylthio); C9(Methylthio)

1.078 1 0.931 1 0.954 1 1.025 1 1.127 1 1.211 1 1.181 1 42 3.81 0 2 710.34503 -0.95 29.65 1419.68279

DSPIQCIQAIAENR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex); C6(Methylthio)

1.106 2 9.6 0.984 2 1.6 1.027 2 12.5 1.043 2 10.8 1.168 2 8.5 1.186 2 6.9 1.137 2 3.9 65 5.66 0 3 1048.5883 1.02 70.31 2096.16117

DSPVLIDFFEDTER HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 44 1 4504489 N-Term(iTRAQ4plex) 1.174 12 8.9 0.997 12 6.7 1.088 12 10.2 1.134 12 9.8 1.241 12 6.7 1.262 12 6.8 1.101 12 1.8 95 7.9 0 3 651.35364 1.6 75.65 1952.04636

DSSCGTGYELTEDNSCK FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

6 4 34734066;34734062

N-Term(iTRAQ4plex); C4(Methylthio); C16(Methylthio); K17(iTRAQ4plex)

1.254 1 0.906 1 1.16 1 1.281 1 1.23 1 1.357 1 1.06 1 84 7.85 1 3 828.77283 1.65 42.56 2484.30393

DSSFIR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 1 1 169636415 N-Term(iTRAQ4plex) 1.185 2 2.3 0.949 2 5.6 1.086 2 6.3 1.145 2 0.7 1.223 2 3.8 1.289 2 1.8 1.126 2 2.5 76 6.66 0 3 1096.0923 2.07 45.29 2191.17313

DSSTWLTAFVLK C4A complement C4-A isoform 1 preproprotein [Homo sapiens]

720 NP_009224 XP_003403837

14 4 67190748 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.187 4 19.5 1.249 4 15 1.166 4 7.8 1.009 4 12.2 1.51 4 49.6 1.209 4 32.8 1.118 4 22.8 71 8.11 0 3 920.43518 0.53 69.1 2759.29099

DSSVPNTGTAR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 25 2 38016947 N-Term(iTRAQ4plex) 1.257 3 24.2 0.931 3 6.9 1.195 3 16 1.162 3 16 1.501 3 1.8 1.311 3 33.4 1.142 3 14.2 71 5.54 0 3 716.40308 -2.08 81.12 2147.19797

DSTEQFQEYYR WDR47 WD repeat-containing protein 47 isoform 3 [Homo sapiens]

22911 NP_001136023 1 3 216548382 N-Term(iTRAQ4plex) 1.318 3 12.7 1.053 3 21.2 1.282 3 25.9 1.181 3 2.3 1.424 3 21.1 1.352 3 0.1 1.111 3 2.1 66 8.75 0 4 957.82147 2.99 45.31 2871.44204

DSVTETLPR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 4 1 4503627 N-Term(iTRAQ4plex) 1.274 2 1.9 0.935 2 25.6 1.176 2 14.2 1.258 2 11 1.298 2 6.7 1.389 2 18.6 1.104 2 7.5 62 4.99 0 2 885.9787 -0.87 47.81 1770.95012

DSVTGTLPK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 4 1 78191798 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.176 4 3.3 1.04 4 8.5 1.076 4 9.5 1.042 4 10 1.236 4 13.3 1.228 4 6.2 1.149 4 3.8 62 5.02 0 2 822.93842 -8.54 20.67 1644.87688

DSVTLK FCGR3A;FCGR3B

low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor [Homo sapiens];low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor [Homo sapiens]

2214;2215 NP_001121068;NP_000561

1 6 189083842;132814489

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.068 2 0.8 1.03 2 1.5 0.981 2 5.9 0.952 2 4.4 1.187 2 5 1.152 2 6.5 1.21 2 10.9 53 7.06 0 3 1019.5407 0.02 44.66 2038.06876

DSYVGDEAQSK ACTB;ACTG2

actin, cytoplasmic 1 [Homo sapiens];actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

60;72 NP_001092;NP_001606

6 6 4501885;4501889

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.005 3 12.7 1.025 3 0.1 0.95 3 21.6 0.927 3 0.6 1.084 3 19.5 1.059 3 0.2 1.14 3 0.9 53 6.75 0 3 952.97125 -2.82 15.63 1904.93717

DTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 7 1 4557485 N-Term(iTRAQ4plex); C27(Methylthio); K38(iTRAQ4plex)

1.646 1 0.874 1 1.564 1 1.789 1 1.52 1 1.739 1 0.972 1 51 6.22 0 3 729.38824 1.2 40.58 2186.15018

DTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 7 1 4557485 N-Term(iTRAQ4plex); M15(Oxidation); C27(Methylthio); K38(iTRAQ4plex)

1.61 1 1.021 1 1.504 1 1.473 1 1.749 1 1.713 1 1.163 1 50 5.62 0 3 952.97125 -2.82 15.63 1920.93436

DTCFEGGDITTVFTPSAK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 3 1 4503627 N-Term(iTRAQ4plex); C3(Methylthio); K18(iTRAQ4plex)

1.174 2 3.1 0.845 2 35.5 1.12 2 0.6 1.325 2 34.8 1.053 2 25.9 1.246 2 8.9 0.94 2 25.3 49 6.21 0 4 496.20755 -8.82 31.35 1981.80837

DTDGDGRGDACDDDMDGDGIK

THBS4 thrombospondin-4 precursor [Homo sapiens]

7060 NP_003239 2 1 31543806 N-Term(iTRAQ4plex); C11(Methylthio); K21(iTRAQ4plex)

1.132 2 14.1 0.87 2 7.7 0.993 2 15.5 1.142 2 7.7 1.124 2 19.8 1.293 2 12 1.132 2 4.2 44 0 2 595.34729 1.12 38.2 1189.6873

DTDLDGFPDEK COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 4 1 40217843 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.085 1 0.893 1 0.958 1 1.073 1 1.096 1 1.227 1 1.144 1 44 3.05 0 2 488.30661 -1.84 13.42 975.60594

DTDMDGVGDQCDNCPLEHNPDQLDSDSDR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 1 40317626 N-Term(iTRAQ4plex); C11(Methylthio); C14(Methylthio)

1.027 2 0.7 0.879 2 9.4 0.883 2 2.5 1.005 2 6.8 1.048 2 4.7 1.192 2 4.7 1.186 2 2.2 44 3.65 0 2 703.88049 -0.86 49.61 1406.75371

DTDMDGVGDQCDNCPLEHNPDQLDSDSDR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 2 1 40317626 N-Term(iTRAQ4plex); M4(Oxidation); C11(Methylthio); C14(Methylthio)

1.478 1 0.867 1 1.276 1 1.472 1 1.484 1 1.711 1 1.163 1 42 2.94 0 2 517.31024 -0.01 14.01 1033.61321

DTDTGALLFIGK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 25 1 39725934 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.151 1 0.957 1 1.061 1 1.108 1 1.192 1 1.245 1 1.123 1 38 3.88 0 2 670.85199 -0.03 53.55 1340.6967

DTEDQEDQVDPR PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 5 1 4506115 N-Term(iTRAQ4plex) 2.701 76 21.2 0.943 75 22.7 2.542 75 25.4 2.641 76 37 2.857 75 25.4 2.974 76 30.1 1.14 76 17.6 126 10.72 0 4 1178.5785 0.76 74.08 3533.72353

DTEEEDFHVDQVTTVK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 15 1 189163538 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

2.799 7 16.6 0.869 7 10.7 2.643 7 17.4 2.85 7 30.9 2.75 7 30.3 3.109 7 13.9 1.131 7 19.4 115 8.94 0 3 1178.5785 0.76 74.08 3549.71372

DTEVLLVGLEPGTR PTPRJ receptor-type tyrosine-protein phosphatase eta isoform 2 precursor [Homo sapiens]

5795 NP_001091973 2 2 148728160 N-Term(iTRAQ4plex) 2.036 27 11.1 0.958 27 3.7 1.922 27 10.9 1.945 27 7.6 2.149 27 9 2.208 27 9.6 1.137 27 3.9 115 4.99 0 2 734.42139 -3.75 32.33 1467.8355

DTGTYGFLLPER CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 4 1 126273569 N-Term(iTRAQ4plex) 1.44 6 10.6 1.066 6 22.9 1.48 6 19.5 1.402 6 17.6 1.321 6 14.7 1.342 6 32.1 1.056 6 25.7 112 11.83 1 4 1406.72 5.46 65.57 4218.13833

DTLPSCAVR PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 5 1 156616294 N-Term(iTRAQ4plex); C6(Methylthio)

2.74 4 4.8 1.015 4 8.1 2.701 4 11.4 2.675 4 7.2 2.848 4 5.8 2.805 4 2.7 1.071 4 6.3 108 6.01 0 2 976.52911 -3.58 31.79 1952.05095

DTMVEDLVVLVR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 16 1 4557391 N-Term(iTRAQ4plex) 1.855 16 35.7 0.974 16 9.4 1.916 16 33 1.888 16 30.8 1.949 16 39.7 1.966 16 34.8 1.131 16 7.3 107 5.98 0 3 1077.0116 -12.29 24.15 2153.01592

DTMVEDLVVLVR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 4 1 4557391 N-Term(iTRAQ4plex); M3(Oxidation)

2.288 18 27.8 0.917 18 32.7 1.938 18 44.8 2.205 18 20.6 2.248 18 37.7 2.423 18 19.3 1.118 18 9 101 8.85 0 3 1304.1744 -4.72 36.78 2607.3416

DTNRPLEPPSEFIVK CDH11 cadherin-11 preproprotein [Homo sapiens]

1009 NP_001788 1 1 16306532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.409 53 14.7 0.919 53 14.9 2.195 53 19.7 2.34 53 16.5 2.391 53 17.9 2.656 53 15.9 1.111 53 7.9 96 4.82 0 2 840.95056 4.64 68.94 1680.88677

DTSCVNPPTVQNAYIVSR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 16 1 62739186 N-Term(iTRAQ4plex); C4(Methylthio)

1.989 42 23 0.92 42 17.9 1.878 42 31.1 2.078 42 22.3 2.132 42 25.8 2.315 42 25.4 1.134 42 8 93 5.42 0 2 886.99878 -1.23 50.08 1772.98955

DTTVIPVSK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 2 1 21264359 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.589 63 17.9 0.956 63 12.4 2.378 63 20.5 2.5 63 17.7 2.635 63 19.6 2.737 63 16 1.113 63 4.7 91 5.63 0 2 954.55939 1.57 76.92 1908.10954

DTVIKPLLVEPEGLEK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K16(iTRAQ4plex)

2.45 17 11.8 1.013 17 9.1 2.271 17 20.3 2.36 17 8.2 2.524 17 19 2.607 17 13.8 1.116 17 3.7 83 4.81 0 2 743.37341 -6.9 25.35 1485.73955

DTWVEHWPEEDECQDEENQK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 12 1 115298678 N-Term(iTRAQ4plex); C13(Methylthio); K20(iTRAQ4plex)

2.177 14 30.4 0.957 14 13 1.899 14 25.4 2.13 14 31 2.116 14 25.7 2.412 14 35.7 1.135 14 2.4 81 4.51 0 2 725.90155 -5.1 30.67 1450.79582

DTYFVTGIVSWGEGCAR F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 6 1 4503625 N-Term(iTRAQ4plex); C15(Methylthio)

2.623 14 9.5 0.992 14 8.8 2.472 14 10 2.472 14 15.1 2.817 14 12.5 2.759 14 16.3 1.126 14 7.7 81 6.11 0 3 939.99683 3.89 16.3 1878.97539

DVAAEAGVSK CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 6 2 330688397 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

3.042 2 3.2 1.069 2 9.9 2.981 2 1.3 2.788 2 11.2 3.316 2 4.7 3.101 2 5.2 1.112 2 6 76 7.14 0 3 1304.1744 -4.72 36.78 2623.34195

DVAPGTLCDVAGWGIVNHAGR

CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 6 1 42544239 N-Term(iTRAQ4plex); C8(Methylthio)

2.717 27 25.8 0.848 24 23.2 2.355 26 25.5 2.714 25 14.2 2.472 26 31.8 2.908 24 27 1.078 27 20 71 9.97 0 3 1076.9179 -1.84 58.86 3228.7542

DVCDPGNTK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 20 2 32483410 N-Term(iTRAQ4plex); C3(Methylthio); K9(iTRAQ4plex)

2.264 4 47.7 0.947 4 4.7 2.1 4 48.1 2.225 4 49.6 2.298 4 45.9 2.438 4 47.7 1.108 4 11 64 5.28 0 2 799.90546 -2.98 38.34 1598.80364

DVDECSLKPSICGTAVCK PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 3 1 192447438 N-Term(iTRAQ4plex); C5(Methylthio); K8(iTRAQ4plex); C12(Methylthio); C17(Methylthio); K18(iTRAQ4plex)

3.619 5 11.9 1.002 5 10.3 3.292 5 19.4 3.564 5 1.8 3.654 5 21 3.919 5 2.1 1.107 5 1 61 3.44 0 2 743.37341 -6.9 25.35 1501.74358

DVDGAYMTK KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 1 2 119395750 N-Term(iTRAQ4plex); M7(Oxidation); K9(iTRAQ4plex)

1.665 3 29 1.085 3 2.6 1.67 3 21.7 1.539 3 36.7 1.801 3 20.7 1.659 3 35.6 1.085 3 1 58 4.34 0 2 674.35742 -7.12 37.37 1347.70757

DVDIDSYPDEELPCSAR THBS4 thrombospondin-4 precursor [Homo sapiens]

7060 NP_003239 2 1 31543806 N-Term(iTRAQ4plex); C14(Methylthio)

2.354 9 23.7 0.92 9 16.7 2.287 9 30.1 2.181 9 27.2 2.373 9 29.8 2.628 9 20.2 1.122 9 10.3 57 3.94 0 3 478.57788 0.64 31.56 1433.71916

DVDKEFYLFPTVFDENESLLLEDNIR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 384 1 4557485 N-Term(iTRAQ4plex); K4(iTRAQ4plex)

2.607 1 0.679 1 2.014 1 2.967 1 2.363 1 3.482 1 1.173 1 57 7.99 0 3 829.76404 1.67 56.17 2487.27756

DVDNAYMIK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.995 3 46.9 1.035 3 0.1 1.93 3 46.5 1.864 3 28.6 2.129 3 47.4 2.057 3 26.3 1.109 3 0.8 48 3.25 0 2 525.80701 -14.53 16.99 1050.62358

DVDNAYMIK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); M7(Oxidation); K9(iTRAQ4plex)

2.162 2 23.5 1.084 2 8.3 2.129 2 17.7 1.963 2 26.3 2.38 2 20.2 2.195 2 28.8 1.118 2 2.3 45 3.15 0 2 674.35742 -7.12 37.37 1363.70354

DVFLEMNIPYSVVR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 7 2 38016947 N-Term(iTRAQ4plex) 2.513 7 8.1 0.984 7 24.7 2.303 7 21.4 2.341 7 13.5 2.682 7 17.2 2.87 7 19.6 1.165 7 14.2 45 8.26 0 4 965.81897 -0.49 31.28 2895.44253

DVFLEMNIPYSVVR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); M6(Oxidation)

2.385 4 10.1 1.122 4 8 2.282 4 8.5 2.313 4 20.8 2.474 4 6 2.544 4 23 1.091 4 1.6 42 0 2 567.80804 -1.71 18.64 1134.60881

DVGVVCSR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C6(Methylthio)

2.49 8 28.1 0.959 8 7.4 2.258 8 45 2.39 8 23.4 2.547 8 47 2.684 8 21.2 1.114 8 2.8 38 2.91 0 2 524.33344 -5.4 26.52 1047.65959

DVRDYFMPCPGR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 1 1 11321561 N-Term(iTRAQ4plex); M7(Oxidation); C9(Methylthio)

2.1 2 5.8 0.904 2 8.1 1.969 2 2.1 2.178 2 10.2 2.032 2 1.9 2.247 2 10 1.032 2 0.3 36 3.47 0 3 375.56079 1.9 12.18 1124.66782

DVSSSVYSTWK KIT mast/stem cell growth factor receptor Kit isoform 2 precursor [Homo sapiens]

3815 NP_001087241 2 2 148005039 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.629 2 39.6 0.898 2 19.9 2.447 2 35.3 2.725 2 58.1 2.551 2 24 2.84 2 45.5 1.042 2 10.6 35 4 0 3 1264.2266 0.07 19.76 2527.44577

DVVLFEK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 63 2 4505881 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

3.273 2 26.8 0.812 2 4 2.89 2 28.1 3.56 2 23.9 3.04 2 29.3 3.745 2 25.1 1.052 2 1.1 33 6.37 0 3 965.81897 -0.49 31.28 2911.41721

DVVLTTTFVDDIK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 96 1 4502511 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.784 1 1.077 1 2.701 1 2.508 1 3.08 1 2.86 1 1.14 1 31 0 2 449.23306 -0.19 5.62 897.45885

DVVQITCLDGFEVVEGR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 18 1 41393602 N-Term(iTRAQ4plex); C7(Methylthio)

2.591 1 0.919 1 2.351 1 2.56 1 2.62 1 2.852 1 1.114 1 3.47 0 2 609.83392 5.86 16.46 1218.66057

DVWGIEGPIDAAFTR VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 96 1 88853069 N-Term(iTRAQ4plex) 1.59 2 15.1 0.99 2 8.8 1.416 2 28.9 1.431 2 19.7 1.745 2 12.2 1.763 2 3.3 1.233 2 16.3 87 7.44 0 3 718.70215 -0.35 29.29 2154.09189

DWAESTLMTQK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 12 1 4503625 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.246 3 10.7 0.93 3 25.8 1.014 3 24.3 1.253 3 14.2 1.242 3 1.9 1.629 3 15.3 1.209 3 3.4 81 6.17 0 3 910.74268 2.6 68.92 2730.21347

DWAESTLMTQK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 8 1 4503625 N-Term(iTRAQ4plex); M8(Oxidation); K11(iTRAQ4plex)

1.458 1 0.701 1 1.147 1 1.637 1 1.333 1 1.902 1 1.162 1 73 3.67 0 2 682.88257 -6.27 19.4 1364.75786

DWHGVPGQVDAAMAGR VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 178 1 88853069 N-Term(iTRAQ4plex) 1.638 2 19.3 0.966 2 0.6 1.49 2 20.8 1.543 2 21.4 1.729 2 17.4 1.791 2 18 1.16 2 3.3 73 3.96 0 2 829.41962 -0.08 45.88 1657.82805

DWHGVPGQVDAAMAGR VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 12 1 88853069 N-Term(iTRAQ4plex); M13(Oxidation)

1.507 3 12.4 0.984 3 48.6 1.4 3 38.2 1.423 3 0.9 1.589 3 31.2 1.63 3 1.4 1.152 3 2.3 73 4.25 0 3 980.92664 -4.58 37.02 1960.84604

DYAEVGR HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 7 2 4826762 N-Term(iTRAQ4plex) 1.69 2 6.4 0.851 2 12.1 1.449 2 13.7 1.702 2 1.6 1.682 2 10.5 1.976 2 1.5 1.161 2 3.1 61 3.27 0 2 777.85962 -3.32 26.07 1554.71196

DYAGVFSDAGLTFTSSSGQQTAQR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 16 1 115298678 N-Term(iTRAQ4plex) 1.643 2 30.1 0.957 2 0 1.407 2 18.2 1.471 2 18.2 1.8 2 39.8 1.882 2 39.8 1.279 2 20.5 59 5.99 0 3 843.74158 0.04 51.71 2529.21018

DYEILFK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 4 1 4503987 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.594 1 1.035 1 1.528 1 1.476 1 1.717 1 1.658 1 1.124 1 53 3.47 0 2 646.8266 1.17 45.08 1292.64592

DYFIATCK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

27 1 66347875 N-Term(iTRAQ4plex); C7(Methylthio); K8(iTRAQ4plex)

1.395 1 0.898 1 1.286 1 1.432 1 1.361 1 1.516 1 1.059 1 36 7.11 1 3 934.47528 1.49 44.76 2801.41129

DYFMPCPGR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 247 1 11321561 N-Term(iTRAQ4plex); C6(Methylthio)

1.427 2 3.7 0.895 2 6.5 1.297 2 8.7 1.45 2 2.2 1.407 2 5 1.573 2 1.5 1.085 2 3.7 36 3.25 0 2 627.32672 -0.1 42.09 1253.64409

DYFMPCPGR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 27 1 11321561 N-Term(iTRAQ4plex); M4(Oxidation); C6(Methylthio)

1.612 1 0.887 1 1.378 1 1.554 1 1.663 1 1.875 1 1.207 1 29 0 2 545.73883 -0.19 44.79 1090.47038

DYIEFNK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 39 1 4502337 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.751 1 0.929 1 0.677 1 0.728 1 0.771 1 0.83 1 1.14 1 5.22 1 3 817.75293 0.94 40.92 2451.24424

DYIFGNYIER ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 16 1 133925809 N-Term(iTRAQ4plex) 1.401 1 0.885 1 1.267 1 1.431 1 1.375 1 1.553 1 1.085 1 3.46 0 2 960.51788 -1.18 48.57 1920.02849

DYLIEDGTVHLVYGILEEPFR

DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex) 1.339 1 0.891 1 1.274 1 1.429 1 1.258 1 1.412 1 0.988 1 32 4.13 0 3 674.72064 -1.98 63.9 2022.14737

DYNLNDILLQLGIEEAFTSK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 227 1 50659080 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.29 2 19.6 0.965 2 3.7 1.2 2 25 1.244 2 21.1 1.334 2 18.3 1.383 2 14.5 1.112 2 6.5 28 2.8 0 2 536.85376 0.26 33.66 1072.70244

DYNLNDILLQLGIEEAFTSKADLSGITGAR

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 6 1 50659080 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.294 1 1.089 1 1.302 1 1.195 1 1.401 1 1.286 1 1.076 1 3.43 2 3 628.70526 2.15 26.99 1884.10123

DYQELMNVK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 7 5 47132620 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.087 1 0.776 1 0.87 1 1.122 1 1.059 1 1.365 1 1.217 1 3.08 0 2 732.90436 0.88 49.41 1464.80144

DYQYYFSK LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 2 2 341915493 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.582 1 0.913 1 1.396 1 1.53 1 1.63 1 1.786 1 1.167 1 2.83 1 2 774.92267 -15.15 39.4 1548.83806

DYVSQFEGSALGK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 4 1 4557321 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.17 2 1.5 0.913 2 17.2 1.084 2 8.1 1.187 2 9 1.159 2 11 1.269 2 6.1 1.069 2 2.9 66 4.26 0 2 755.8764 -4.56 35.64 1510.74553

DYWSTVK APOC3 apolipoprotein C-III precursor [Homo sapiens]

345 NP_000031 5 1 4557323 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.134 1 0.893 1 1.922 1 2.152 1 2.118 1 2.371 1 1.102 1 41 3.21 0 2 617.8595 1.48 36.05 1234.71172

DYYVSTAVCR SPP2 secreted phosphoprotein 24 precursor [Homo sapiens]

6694 NP_008875 2 1 5902118 N-Term(iTRAQ4plex); C9(Methylthio)

1.505 1 0.956 1 1.386 1 1.45 1 1.559 1 1.631 1 1.125 1 39 0 2 750.4129 -0.7 22.06 1499.81853

EAAGMGSVAGSSPFFREEK HIPK4 homeodomain-interacting protein kinase 4 [Homo sapiens]

147746 NP_653286 1 1 31542768 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

2.147 1 0.809 1 1.894 1 2.342 1 1.99 1 2.461 1 1.051 1 37 0 2 596.36859 -3.43 22.69 1191.72991

EACNAWLQK C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 10 1 289547636 N-Term(iTRAQ4plex); C3(Methylthio); K9(iTRAQ4plex)

1.682 9 11.1 0.905 9 13.7 1.449 9 12 1.55 9 22.4 1.65 9 13.7 1.851 9 12.2 1.133 9 4.1 91 6 0 2 1064.9983 -0.93 46.83 2128.98931

EADPESEADR GOLIM4 Golgi integral membrane protein 4 [Homo sapiens]

27333 NP_055313 2 1 7657138 N-Term(iTRAQ4plex) 1.729 8 11.8 0.867 8 8.5 1.529 8 8.2 1.714 8 16.7 1.773 8 8.7 1.988 8 13.8 1.155 8 2.7 84 9.02 0 3 1120.603 1.92 36.44 2240.19724

EAEFGQGTGPIWLNEVK CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.733 11 11.6 0.959 11 7.2 1.574 11 12.6 1.689 11 11.3 1.873 11 12.9 1.904 11 12.5 1.169 11 6.7 80 7.43 0 3 1159.1371 3.68 56.11 2317.26689

EAFAAVSK CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 2 1 126273569 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.529 9 4.8 1.006 9 9.3 1.481 9 18.8 1.446 9 14.1 1.666 9 13.1 1.668 9 11.9 1.147 9 3.6 77 5.44 0 2 926.96411 2.3 71.16 1852.92095

EAGIPEFYDYDVALIK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 116 1 67782358 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.192 8 12.9 0.964 8 7.8 1.135 8 23.4 1.145 8 17.1 1.206 8 15.8 1.279 8 5.7 1.093 8 4.7 72 6.86 1 2 1005.0146 2.04 49.2 2009.0219

EAGYEGPLHQCDIYR ACE angiotensin-converting enzyme isoform 1 precursor [Homo sapiens]

1636 NP_000780 2 1 4503273 N-Term(iTRAQ4plex); C11(Methylthio)

1.863 3 2.2 0.906 3 9.6 1.792 3 18.7 1.588 3 33.5 1.812 3 25 1.807 3 6.4 1.09 3 11.2 72 9.48 0 3 963.1366 6.07 36.31 2887.39524

EALGDVVGDYNFICPALEFTK

BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 14 1 4557351 N-Term(iTRAQ4plex); C14(Methylthio); K21(iTRAQ4plex)

1.353 3 13.7 0.811 3 25.9 1.08 3 21.9 1.304 3 18.8 1.28 3 9.8 1.577 3 15.8 1.11 3 12.7 57 7.78 0 3 821.04578 -1.26 31.3 2461.12278

EALIQFLEQVHQGIK CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 11 1 4503011 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.986 1 0.943 1 0.938 1 0.995 1 0.978 1 1.037 1 1.043 1 57 5.65 0 4 1188.0032 2.73 70.14 4748.99087

EALKESQLPTVMDFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K4(iTRAQ4plex); M12(Oxidation)

1.559 2 11.3 0.979 2 7.6 1.439 2 9.2 1.469 2 16.9 1.648 2 6 1.683 2 13.7 1.145 2 3.2 46 3.48 0 2 566.77148 -0.28 15.83 1132.53569

EALKLEEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); K4(iTRAQ4plex); K8(iTRAQ4plex)

1.839 3 2.6 0.951 3 5.8 1.803 3 12.5 1.812 3 6.7 1.863 3 11.7 2.037 3 6.6 1.124 3 22.1 43 2.78 0 2 495.27844 -0.06 16.46 989.54985

EALQGVGDMGR SAA2-SAA4 SAA2-SAA2 protein precursor [Homo sapiens]

100528017 NP_001186673 2 2 315075331 N-Term(iTRAQ4plex); M9(Oxidation)

1.623 7 10.4 0.95 7 15 1.501 7 15.3 1.566 7 12 1.649 7 19.7 1.8 7 10.5 1.138 7 4.9 43 3.24 0 3 443.89609 12.27 33.48 1329.66948

EALVPLVADHK HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 4 1 4504383 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.805 6 1.6 0.969 6 15.7 1.721 6 9.1 1.777 6 10 1.82 6 1.6 2.012 6 13.2 1.123 6 6.6 42 3.14 0 2 514.34155 1.31 23.53 1027.67449

EANVACLDLGFQQGADTQR

CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 20 1 119392081 N-Term(iTRAQ4plex); C6(Methylthio)

1.342 1 0.965 1 1.275 1 1.322 1 1.361 1 1.411 1 1.067 1 40 5.03 0 3 469.8847 -9.63 23.34 1407.63956

EAPDLVLQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex) 2.249 1 0.971 1 2.117 1 2.181 1 2.316 1 2.386 1 1.094 1 33 0 2 536.30005 1.21 23.81 1071.59282

EAQEVFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.114 1 1.172 1 1.271 1 1.085 1 1.149 1 0.98 1 0.903 1 33 0 3 565.2522 1.23 23.91 1693.74204

EAQLPVIENK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 27 1 4505881 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.481 1 0.937 1 1.373 1 1.465 1 1.495 1 1.596 1 1.089 1 32 2.76 0 2 561.27338 7.33 26.74 1121.53948

EASMEGIVTIVGLKPETTYAVR

NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 3 5 115529482 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.424 3 10.7 0.956 3 1.7 1.312 3 6.7 1.357 3 1.9 1.488 3 7.9 1.54 3 9.5 1.103 3 4.2 31 3.46 0 3 572.77783 1.01 12.31 1144.54804

EATEAAK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 49 1 156523970 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.526 5 4.9 0.958 5 10.5 1.359 5 9.9 1.532 5 8.3 1.635 5 11 1.818 5 8.4 1.187 5 2.9 30 4.61 0 3 1025.0009 1.39 45.88 2048.99063

EATEAAKCNLLAEK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 1 1 156523970 N-Term(iTRAQ4plex); K7(iTRAQ4plex); C8(Methylthio); K14(iTRAQ4plex)

1.537 5 11.2 0.878 5 0.5 1.358 5 16.3 1.579 5 4.2 1.528 5 16.7 1.74 5 3.8 1.122 5 0.7 30 3.35 0 2 598.30615 -2.86 27.96 1195.60918

Page 10: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

EATIPGHLNSYTIK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

12 5 47132549;16933542

N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.149 2 46 1.004 2 3.3 1.084 2 44.5 1.08 2 48.3 1.219 2 43.8 1.214 2 47.6 1.125 2 0.6 27 2.85 0 2 481.20322 0.34 11.43 961.39916

EATLQDCPSGPWGK CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 6 1 5174411 N-Term(iTRAQ4plex); C7(Methylthio); K14(iTRAQ4plex)

1.31 2 22.5 0.621 2 18.9 1.013 2 28 1.632 2 8.8 1.114 2 32 1.794 2 12.6 1.099 2 3.8 7.46 1 6 554.61401 2.9 36.12 3322.6477

EAVEHLQK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 5 1 71773110 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.788 1 1.028 1 1.733 1 1.686 1 1.893 1 1.842 1 1.092 1 3.11 0 2 469.73776 1.48 14.74 938.46825

EAVPEPVLLSR TGFB1 transforming growth factor beta-1 precursor [Homo sapiens]

7040 NP_000651 2 1 63025222 N-Term(iTRAQ4plex) 1.843 1 0.875 1 2.06 1 2.355 1 1.395 1 1.595 1 0.677 1 3.82 2 4 674.86505 7.49 62.24 2696.43838

EAVSGR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

1 3 31542984;262050538

N-Term(iTRAQ4plex) 1.297 1 1.023 1 1.193 1 1.166 1 1.431 1 1.398 1 1.199 1 59 4.67 0 3 529.29865 -0.33 31.13 1585.88138

ECDCDAQCK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 16 4 189181722 N-Term(iTRAQ4plex); C2(Methylthio); C4(Methylthio); C8(Methylthio); K9(iTRAQ4plex)

1.302 1 0.935 1 1.254 1 1.341 1 1.266 1 1.355 1 1.01 1 36 3.07 0 2 563.24353 1.09 22.19 1125.47978

ECDNPAPQNGGASCPGR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 6 1 4557389 N-Term(iTRAQ4plex); C2(Methylthio); C14(Methylthio)

1.468 9 13 1.063 9 4.8 1.402 9 7.5 1.328 9 7.8 1.554 9 20.9 1.463 9 22.2 1.152 9 9.9 106 7.05 0 3 1039.5263 0.93 57.96 2078.03911

ECDTDGWTNDIPICEVVK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 90 2 62739186 N-Term(iTRAQ4plex); C2(Methylthio); C14(Methylthio); K18(iTRAQ4plex)

1.466 12 8.5 0.881 12 21.9 1.354 12 17.1 1.506 12 9.9 1.349 12 11 1.727 12 17.2 1.121 12 14.3 97 7.21 0 3 865.71582 0.11 55.22 2595.13291

ECELPK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 1 1 62739186 N-Term(iTRAQ4plex); C2(Methylthio); K6(iTRAQ4plex)

1.732 14 10.4 1.027 14 14.8 1.619 14 18 1.521 14 13.4 1.766 14 21.8 1.768 14 13 1.127 14 5.2 95 4.93 0 2 769.93988 -6.28 38.5 1538.87248

ECLQTCR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 7 1 4502067 N-Term(iTRAQ4plex); C2(Methylthio); C6(Methylthio)

1.68 5 7 0.98 5 12.9 1.497 5 9.3 1.567 5 8.8 1.695 5 11.6 1.817 5 3.4 1.141 5 4.5 93 7.78 1 3 1185.1747 -0.86 46.91 2369.34299

ECNNPAPQR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 15 1 169636415 N-Term(iTRAQ4plex); C2(Methylthio)

1.224 6 10.2 0.947 6 8.7 1.104 6 15.1 1.216 6 6.7 1.244 6 7.9 1.344 6 10.3 1.153 6 4.3 91 8.62 0 3 879.11615 1.78 69.18 2635.32712

ECNNPPPSGGGR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 19 1 45580688 N-Term(iTRAQ4plex); C2(Methylthio)

1.477 4 5.6 1.088 4 10.6 1.302 4 7.4 1.394 4 20.1 1.493 4 17.4 1.542 4 18.4 1.065 4 9.4 91 8.22 1 3 1233.2301 0.64 45.46 3697.67575

ECQGNGVWSGTEPICR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 2 3 14550407 N-Term(iTRAQ4plex); C2(Methylthio); C15(Methylthio)

1.462 26 10.6 0.967 26 14.4 1.337 26 16.2 1.402 26 9 1.531 26 17.4 1.603 26 10.8 1.128 26 8.8 90 6.44 0 2 1059.0012 -0.22 49.33 2117.00223

ECSQALSLILDIDHGKPVK PLA2G7 platelet-activating factor acetylhydrolase precursor [Homo sapiens]

7941 NP_005075 2 1 189095271 N-Term(iTRAQ4plex); C2(Methylthio); K16(iTRAQ4plex); K19(iTRAQ4plex)

1.47 3 1.3 1.038 3 0.3 1.406 3 7.8 1.355 3 9.8 1.492 3 11.8 1.457 3 9.7 1.073 3 9.5 90 5.57 0 4 971.53705 10.75 32.17 1942.06679

ECVGFEAVQEVPVGLVQPASATLYDYYNPER

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

46 6 178557739;67190748

N-Term(iTRAQ4plex); C2(Methylthio)

1.43 10 11.3 0.88 9 20 1.289 10 16.2 1.468 9 11.8 1.327 10 16.5 1.554 9 14.2 1.092 10 12.4 90 7.98 0 4 1219.9314 0.59 58.47 3657.77964

EDAIWNLLR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex) 1.698 1 0.975 1 1.642 1 1.684 1 1.711 1 1.755 1 1.042 1 87 5.59 0 2 986.41913 0.37 31.66 1971.83098

EDAVLEYLK MSN moesin [Homo sapiens] 4478 NP_002435 3 1 4505257 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.413 2 2.7 0.899 2 1 2.149 2 3.5 2.392 2 4.5 2.432 2 1.1 2.707 2 2.1 1.132 2 2.4 87 5.34 0 3 971.53705 10.75 32.17 1958.05552

EDEDFQESNK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.589 2 19.4 0.981 2 2.6 1.547 2 16.8 1.576 2 14.1 1.6 2 24.6 1.631 2 21.9 1.034 2 7.6 82 6.44 0 3 920.94672 1.01 48.66 1840.88724

EDFDVEAADSAGNCLDSLVFVAGDR

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 2 1 41393602 N-Term(iTRAQ4plex); C14(Methylthio)

1.36 6 8.4 0.971 6 14.2 1.258 6 12.4 1.316 6 10.3 1.353 6 2.8 1.469 6 8.1 1.101 6 1.5 82 5.51 0 3 1001.5001 -5.67 45.4 2002.00083

EDFLEQSEQLFGAKPVSLTGK

SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 2 2 115583663 N-Term(iTRAQ4plex); K14(iTRAQ4plex); K21(iTRAQ4plex)

1.787 7 27.4 1.004 7 6.5 1.718 7 28.6 1.692 7 30.3 1.877 7 18 1.995 7 16.6 1.123 7 5.8 82 5.22 0 3 869.44446 1.8 37.17 1737.8787

EDFTSLSLVLYSR GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 189 2 32483410 N-Term(iTRAQ4plex) 1.363 12 14.2 0.914 12 4.3 1.251 12 8 1.376 12 14.4 1.398 12 12.6 1.489 12 14.7 1.108 12 4.7 79 4.99 0 2 771.87256 0.35 35.07 1542.73113

EDGILGPIIR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 1.522 5 2.6 1.03 5 12.1 1.483 5 7.3 1.469 5 4.3 1.665 5 7.6 1.631 5 3.6 1.13 5 3.4 78 4.44 0 2 696.37396 -1.96 44.2 1391.74065

EDIFMETLK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 27 1 4502337 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.217 16 7.3 0.974 16 7.8 1.159 16 10.4 1.184 16 10.4 1.288 16 10.3 1.323 16 9.5 1.12 16 4.7 75 5.98 0 2 869.44446 1.8 37.17 1721.88828

EDIFMETLK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 1 1 4502337 N-Term(iTRAQ4plex); M5(Oxidation); K9(iTRAQ4plex)

1.542 4 5.8 0.963 4 6.3 1.361 4 8.3 1.527 4 0.1 1.556 4 5.1 1.739 4 4.3 1.14 4 0.8 74 4.63 0 2 633.33191 -3.28 20.06 1265.65654

EDIPPADLSDQVPDTESETR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 67 1 115298678 N-Term(iTRAQ4plex) 1.707 2 12.9 0.927 2 19.9 1.563 2 23.3 1.686 2 3.3 1.734 2 22 1.871 2 2 1.11 2 1.2 70 3.76 0 2 684.9231 -4.7 17.68 1368.83891

EDKVVASRLTPESQGLLK ZKSCAN3 zinc finger protein with KRAB and SCAN domains 3 isoform 2 [Homo sapiens]

80317 NP_001229824 1 2 339276021 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K18(iTRAQ4plex)

1.342 1 0.643 1 0.998 1 1.551 1 1.208 1 1.877 1 1.21 1 66 4.51 0 2 864.97357 -0.71 55.79 1728.93987

EDLKDDQK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K4(iTRAQ4plex); K8(iTRAQ4plex)

1.533 12 9.6 0.959 12 8.7 1.425 12 11.3 1.473 12 11.1 1.536 12 14.6 1.609 12 5.9 1.1 12 11.1 65 4.13 0 3 755.42889 -2.73 71.29 1509.85051

EDSCQLGYSAGPCMGMTSR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 8 1 4502067 N-Term(iTRAQ4plex); C4(Methylthio); C13(Methylthio); M14(Oxidation)

1.657 11 8.2 0.94 11 13.1 1.579 11 15.7 1.553 11 14.8 1.778 11 17.5 1.732 11 13.6 1.133 11 6.9 64 6.12 0 3 699.71985 -1 68.57 2097.14499

EDSCQLGYSAGPCMGMTSR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 4 1 4502067 N-Term(iTRAQ4plex); C4(Methylthio); C13(Methylthio); M14(Oxidation); M16(Oxidation)

3.334 3 45 0.707 3 4.3 3.708 3 119.2 2.783 3 10.1 4.38 3 123 3.245 3 8.2 1.166 3 1.9 60 6.01 0 3 1219.9314 0.59 58.47 3673.75705

EDSCQLGYSAGPCMGMTSR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 2 1 4502067 N-Term(iTRAQ4plex); C4(Methylthio); C13(Methylthio)

1.804 3 7.9 1.087 3 0.8 1.721 3 11.5 1.763 3 6.5 2.053 3 6.9 1.88 3 3.2 1.074 3 4.3 58 3.26 0 2 696.37396 -1.96 44.2 1407.74004

EDTPNSVWEPAK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 12 1 41393602 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.617 4 4.3 0.994 4 6.1 1.532 4 4.2 1.522 4 4.8 1.716 4 3.8 1.657 4 7.8 1.148 4 4 56 4.81 0 2 710.36084 3.27 24.66 1419.7144

EDTSFFGVQEIIIHDQYK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.564 5 15.7 1.029 5 4 1.469 5 11.5 1.571 5 18.3 1.693 5 9.9 1.687 5 7.6 1.119 5 4.3 54 5.98 1 2 943.01697 -8.25 31.53 1885.03838

EDVYVVGTVLR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 21 1 4502503 N-Term(iTRAQ4plex) 1.656 7 2.5 0.839 7 22.4 1.333 7 23.4 1.578 7 4.8 1.589 7 18.9 1.831 7 5 1.133 7 4.9 54 4.26 0 2 576.29504 -1.68 29.45 1151.58281

EDYIYGFQFK ART3 ecto-ADP-ribosyltransferase 3 isoform c precursor [Homo sapiens]

419 NP_001123489 2 3 194097382 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

3.826 3 4 0.984 3 8 3.381 3 14.6 3.591 3 16.8 3.856 3 8 3.919 3 23.6 1.129 3 1.5 51 3.54 0 2 869.44446 1.8 37.17 1753.86846

EDYLDVYVFGVGPLVNQVNINALASK

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 61 1 67782358 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.443 7 4.3 0.801 7 8.2 1.222 7 9.1 1.489 7 5.5 1.386 7 5.2 1.74 7 6.4 1.171 7 4.8 45 3.13 0 2 576.29504 -1.68 29.45 1167.57524

EEAFLGITDEK MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 2 1 4557739 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.904 3 9.1 1.172 3 5.9 0.92 3 7 0.786 3 12.9 1.042 3 4.8 0.889 3 10.8 1.132 3 0.3 44 3 0 2 630.38525 5.59 17.08 1259.75493

EEALALMNR VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 2 1 223633991 N-Term(iTRAQ4plex) 1.19 3 7.9 0.898 3 0.8 1.104 3 7.7 1.237 3 18.1 1.166 3 2.1 1.287 3 8.9 1.041 3 2.8 44 3.93 0 3 402.55661 0.4 27.35 1205.65528

EEAPSLRPAPPPISGGGYR FGB fibrinogen beta chain isoform 1 preproprotein [Homo sapiens]

2244 NP_005132 2 1 70906435 N-Term(iTRAQ4plex) 1.605 1 1.114 1 1.583 1 1.42 1 1.812 1 1.626 1 1.145 1 42 2.75 0 2 501.83075 -0.78 24.25 1002.65422

EEASDYLELDTIK HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 2 1 4507677 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.242 3 8.5 1.002 3 7.4 1.178 3 7 1.242 3 0.4 1.284 3 5.1 1.309 3 10.5 1.13 3 1.7 41 3.17 0 2 533.28302 -1.29 7.22 1065.55876

EEFPFALGVQTLPQTCDEPK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex); C16(Methylthio); K20(iTRAQ4plex)

1.459 3 3.3 0.958 3 1.2 1.348 3 9.6 1.515 3 4.8 1.458 3 8.8 1.654 3 4.3 1.088 3 0.5 37 4.65 0 3 700.37494 0.43 15.01 1399.7426

EEGTDLEVTANR PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex) 1.213 1 0.908 1 1.12 1 1.234 1 1.194 1 1.316 1 1.066 1 34 0 2 533.82104 -3.64 18.06 1066.63481

EEIIYECDK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 20 1 4502503 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

1.562 2 5.7 1.057 2 8.7 1.535 2 13.4 1.452 2 4.7 1.68 2 7.3 1.589 2 1.4 1.094 2 6.1 34 0 2 508.80325 1.31 14.29 1016.59923

EEILMHLWR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 4 1 21071039 N-Term(iTRAQ4plex) 1.34 1 1.047 1 1.288 1 1.231 1 1.455 1 1.39 1 1.129 1 57 6.02 0 3 646.02594 -1.45 57.49 1936.06327

EEIVDKYDLFVGSQATDFGEALVR

CALU calumenin isoform f [Homo sapiens] 813 NP_001186603 4 5 314122183 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.179 2 13.1 1.015 2 15.5 1.122 2 6.5 1.106 2 22.2 1.256 2 4.1 1.238 2 19.7 1.12 2 2.4 70 8.39 0 3 751.71698 -2.28 36.54 2253.13639

EELATFDPVDNIVFNMAAGSAPMQLHLR

APOM apolipoprotein M isoform 2 [Homo sapiens]

55937 NP_001243098 12 1 22091452 N-Term(iTRAQ4plex) 0.85 1 0.845 1 0.671 1 0.795 1 0.896 1 1.061 1 1.335 1 61 3.51 0 2 736.87616 -0.8 22.61 1472.74504

EELATFDPVDNIVFNMAAGSAPMQLHLR

APOM apolipoprotein M isoform 2 [Homo sapiens]

55937 NP_001243098 4 1 22091452 N-Term(iTRAQ4plex); M23(Oxidation)

0.879 1 0.936 1 0.79 1 0.843 1 0.912 1 0.974 1 1.155 1 43 6.35 0 4 618.55365 -1.67 40.36 2471.19277

EELCTMFIR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); C4(Methylthio); M6(Oxidation)

39.989 1 0.577 1 26.695 1 46.289 1 36.356 1 63.042 1 1.362 1 59 5.97 0 4 795.42151 0.57 45.72 3178.66421

EELLPAQDIK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 96 1 67782358 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.135 1 0.925 1 0.963 1 1.041 1 1.221 1 1.319 1 1.267 1 4.01 0 3 673.72131 -2.87 58.39 2019.14939

EELVYELNPLDHR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

223 6 178557739;67190748

N-Term(iTRAQ4plex) 1.395 3 12.2 0.979 3 5.3 1.329 3 6.7 1.357 3 21.4 1.431 3 3.8 1.462 3 9.1 1.169 3 7.8 38 3.11 0 2 620.35242 -0.03 28.37 1239.69756

EENDDFASFR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 3 1 4504489 N-Term(iTRAQ4plex) 1.16 1 0.974 1 1.087 1 1.117 1 1.201 1 1.234 1 1.105 1 82 4.19 0 2 834.97302 -1.4 27.67 1668.93877

EENFYVDETTVVK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 66 1 73858564 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.155 1 0.91 1 0.974 1 1.071 1 1.232 1 1.354 1 1.264 1 81 3.89 0 2 773.90015 -3.98 22.61 1546.79302

EEPVEALTFSR LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 2 5 261337173 N-Term(iTRAQ4plex) 1.315 1 1.053 1 1.277 1 1.213 1 1.422 1 1.351 1 1.114 1 65 4.34 0 2 713.88354 -5.53 35.39 1426.75981

EESLDSDLYAELR PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 16 1 4505981 N-Term(iTRAQ4plex) 1.468 1 0.884 1 1.262 1 1.428 1 1.503 1 1.701 1 1.191 1 61 3.87 0 2 596.34381 -0.89 16.11 1191.68035

EESPLLIGQQSTVSDVPR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

24 5 47132549;16933542

N-Term(iTRAQ4plex) 1.056 1 0.876 1 0.975 1 1.114 1 1.006 1 1.149 1 1.031 1 48 0 3 421.23724 -3.92 20.72 1261.69718

EESSSGSSHAVMDISLPTGISANEEDLK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 6 2 38016947 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.253 1 1.11 1 1.381 1 1.244 1 1.263 1 1.138 1 0.915 1 4.55 0 3 992.8476 1.53 59.15 2976.52823

EESSSGSSHAVMDISLPTGISANEEDLK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); M12(Oxidation); K28(iTRAQ4plex)

0.963 1 0.991 1 0.868 1 0.876 1 1.049 1 1.059 1 1.209 1 77 3.92 0 2 997.96582 -1.84 44.11 1994.92436

EETGQVLER MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 3 1 71274107 N-Term(iTRAQ4plex) 1.139 1 0.972 1 1.066 1 1.097 1 1.18 1 1.214 1 1.107 1 33 3.14 0 2 860.45166 1.18 74.64 1719.89604

EETTSHLR KNG1 kininogen-1 isoform 2 precursor [Homo sapiens]

3827 NP_000884 24 2 4504893 N-Term(iTRAQ4plex) 1.21 1 0.913 1 1.074 1 1.177 1 1.241 1 1.359 1 1.155 1 2.9 0 2 589.8468 -0.66 20.38 1178.68633

EEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWER

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

6 5 47132549;16933542

N-Term(iTRAQ4plex); C22(Methylthio)

0.89 1 0.922 1 0.811 1 0.88 1 0.9 1 0.975 1 1.109 1 2.78 0 2 581.27557 -1.36 46.63 1161.54387

EEYFDPSIVGWTVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.172 3 10.6 1.034 3 2.1 1.152 3 15.2 1.099 3 0.3 1.249 3 18.3 1.199 3 1 1.093 3 1.3 112 6.03 0 3 1029.0355 0.27 29.23 2057.06028

EEYGHSEVVEYYCNPR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 22 1 62739186 N-Term(iTRAQ4plex); C13(Methylthio)

1.116 1 1.084 1 1.111 1 1.025 1 1.214 1 1.12 1 1.093 1 79 4.31 0 2 909.03796 -4.9 46.15 1817.06865

EEYSNLK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 3 21450863 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.941 1 0.906 1 0.826 1 0.913 1 0.967 1 1.068 1 1.171 1 68 4.76 0 2 821.96399 4.51 33.07 1642.9207

EFCDLPR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); C3(Methylthio)

1.429 1 0.817 1 1.237 1 1.513 1 1.36 1 1.663 1 1.099 1 33 0 2 559.79437 16.26 31.04 1118.58147

EFDHNSNIR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 12 1 62739186 N-Term(iTRAQ4plex) 1.281 1 0.842 1 1.129 1 1.34 1 1.232 1 1.463 1 1.092 1 45 5.22 0 3 550.94391 -2.51 27.17 1650.81717

EFGNTLEDK APOC1 apolipoprotein C-I precursor [Homo sapiens]

341 NP_001636 2 1 4502157 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.907 3 2.5 0.927 3 0.9 0.89 3 3.6 0.806 3 4.2 0.926 3 7.3 0.958 3 6.3 1.12 3 18.3 65 7.09 0 3 701.68799 0.47 41.76 2103.04941

EFHLHLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

3 6 178557739;67190748

N-Term(iTRAQ4plex) 1.135 6 25.1 0.943 5 30.9 1.051 6 12.5 1.251 5 35 0.988 6 10.1 1.037 5 32 0.932 6 16.3 65 8.1 0 4 1137.6287 1.53 79.69 3410.8749

EFLIEK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 1 3 14550407 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.909 1 0.983 1 0.826 1 0.84 1 0.978 1 0.994 1 1.184 1 53 4.17 0 2 642.79736 6.32 25.66 1284.58745

EFLYDVVK COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 2 1 55743098 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.968 1 0.929 1 0.871 1 0.937 1 0.996 1 1.072 1 1.144 1 45 3.28 0 2 629.39319 -0.73 42.84 1257.7791

EFMEEVIQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex) 0.941 1 0.963 1 0.859 1 0.891 1 0.988 1 1.026 1 1.151 1 44 3.9 0 2 625.33301 0.66 24.25 1249.65874

EFMSQGNK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

6 1 66347875 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.983 2 4.8 0.828 2 14.7 0.889 2 8.9 1.073 2 5.8 0.911 2 14 1.099 2 0.7 1.025 2 5.1 40 6.61 0 3 719.9837 -0.59 61.65 2157.93656

EFMSQGNK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

2 1 66347875 N-Term(iTRAQ4plex); M3(Oxidation); K8(iTRAQ4plex)

1.254 1 0.684 1 0.94 1 1.375 1 1.171 1 1.712 1 1.245 1 3.96 0 3 646.68402 -1.02 53.37 1938.03751

EFNLQNMGLPDFHIPENLFLK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 38 1 105990532 N-Term(iTRAQ4plex); M7(Oxidation); K21(iTRAQ4plex)

0.856 1 0.992 1 0.785 1 0.791 1 0.919 1 0.927 1 1.172 1 33 2.86 0 2 494.78564 9.71 26.28 988.56401

EFNLQNMGLPDFHIPENLFLK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.157 1 1.18 1 1.11 1 0.94 1 1.413 1 1.198 1 1.273 1 3.92 0 4 690.09711 -4.53 45.07 2757.3666

EFNPLVIVGLSK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 12 1 105990535 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.861 1 0.937 1 1.683 1 1.796 1 1.922 1 2.051 1 1.142 1 3.65 1 3 748.08875 10.89 26.02 2242.25168

EFPEVHLGQWYFIAGAAPTK

APOM apolipoprotein M isoform 2 [Homo sapiens]

55937 NP_001243098 9 1 22091452 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.076 1 0.9 1 0.966 1 1.074 1 1.078 1 1.198 1 1.116 1 52 5.85 0 3 778.37604 2.9 34.38 2333.11356

EFQVPTFTIPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 31 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.306 4 4.5 0.957 4 29.4 1.205 4 15.1 1.389 4 14.1 1.358 4 16.8 1.41 4 8.8 1.021 4 15 90 5.46 0 3 934.5918 -3.23 37.94 1868.17325

EFSHLGK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 2 2 32483410 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.42 4 5.4 0.996 4 8.6 1.33 4 8.9 1.374 4 3.7 1.504 4 7.6 1.524 4 1 1.112 4 3.1 68 4.85 0 2 766.43884 -1.23 31.38 1531.86199

EFTEAFLGCPAIHPR PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 24 1 156616294 N-Term(iTRAQ4plex); C9(Methylthio)

1.428 1 0.702 1 1.122 1 1.598 1 1.309 1 1.864 1 1.167 1 67 5.62 0 3 664.3858 4.72 77.32 1991.14286

EFTRPEEIIFLR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 7 1 34734066 N-Term(iTRAQ4plex) 1.281 1 0.833 1 1.121 1 1.346 1 1.228 1 1.474 1 1.096 1 34 3.95 1 3 406.26929 -4.64 12.93 1216.79331

EFYLFPTVFDENESLLLEDNIR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 50 1 4557485 N-Term(iTRAQ4plex) 1.358 1 0.89 1 1.189 1 1.335 1 1.379 1 1.549 1 1.16 1 31 3.56 0 2 523.25085 1.62 40.63 1045.49443

EGAADSPLR LOC100653070

PREDICTED: leukocyte immunoglobulin-like receptor subfamily A member 3-like, partial [Homo sapiens]

100653070 XP_003403896 2 3 341914912 N-Term(iTRAQ4plex) 1.007 112 9.8 0.9 112 13.6 0.894 112 16.9 0.994 112 12.2 0.998 112 12.3 1.151 112 10.1 1.139 112 10 119 10.52 0 3 884.71893 3.51 75.82 2652.14096

EGAFVYSDHSPMR COLEC11 collectin-11 isoform j [Homo sapiens]

78989 NP_001242918 2 10 364502955 N-Term(iTRAQ4plex) 1.032 79 12.9 0.964 79 12.9 0.949 79 12.3 0.997 79 15.4 1.09 79 14.5 1.141 79 13.9 1.15 79 9.6 83 5.78 0 3 1025.5795 2.16 71.67 2050.15532

EGAIHREELVYELNPLDHR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

7 6 178557739;67190748

N-Term(iTRAQ4plex) 1.1 12 7.2 0.944 12 6.8 1.029 12 11.8 1.044 12 6.7 1.154 12 13.1 1.191 12 10.6 1.128 12 2.3 82 5.67 0 3 545.95496 2.14 61.85 1635.85031

EGASEEEIR LOC100653057

PREDICTED: liver carboxylesterase 1-like [Homo sapiens]

100653057 XP_003403927 2 4 341916335 N-Term(iTRAQ4plex) 1.058 81 19.8 0.953 81 15.9 0.963 81 25 1.04 81 24 1.152 81 22.8 1.21 81 18.1 1.152 81 13.2 76 6.05 0 3 1176.5283 0.98 40.41 2352.05069

EGAVLAK QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 2 13325075 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.886 4 12.7 1.03 4 10.7 0.868 4 16.3 0.776 4 18.9 0.904 4 14.4 0.898 4 10 1.172 4 1.6 69 7.22 1 3 1312.6215 -3.22 33.19 2624.22855

EGDALELTCEAIGKPQPVMVTWVR

CADM1 cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

23705 NP_001091987 1 2 148664211 N-Term(iTRAQ4plex); C9(Methylthio); K14(iTRAQ4plex)

1.042 98 17.5 0.959 98 24.7 0.989 98 22.9 1.012 98 15.9 1.112 98 16.2 1.144 98 14.7 1.131 98 11.6 69 7.44 0 3 779.09747 0.52 40.52 2335.27494

EGDCPVQSGK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

16 3 4504893;156231037

N-Term(iTRAQ4plex); C4(Methylthio); K10(iTRAQ4plex)

0.947 57 14.5 0.943 57 16.4 0.892 57 20.8 0.978 57 22.6 0.979 57 21.3 1.069 57 19.5 1.06 57 16.1 69 8.66 0 3 1471.255 1.95 78.84 2941.50273

EGEAAPGAAGASVGAAAATPGAEDWKK

HMX3 homeobox protein HMX3 [Homo sapiens]

340784 NP_001099044 XP_291716 XP_945635

1 1 157743259 N-Term(iTRAQ4plex); K26(iTRAQ4plex); K27(iTRAQ4plex)

1.021 62 10.4 1.028 62 15.4 0.979 62 15 0.99 62 17.3 1.096 62 12.8 1.097 62 14.1 1.118 62 9.2 67 6.97 0 4 1330.6355 0.82 35.41 2660.26645

EGGPSQIGDALGFAVR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 8 1 89191868 N-Term(iTRAQ4plex) 1.798 1 0.928 1 1.647 1 1.775 1 1.82 1 1.962 1 1.105 1 62 2.85 0 2 772.36743 -2.21 26.68 1543.72759

EGIPPDQQR UBB polyubiquitin-B precursor [Homo sapiens]

7314 NP_061828 2 4 11024714 N-Term(iTRAQ4plex) 0.841 87 21.8 0.953 87 13 0.76 87 24.1 0.8 87 21.3 0.889 87 21 0.898 87 22.3 1.152 87 11 55 6.8 1 3 1161.6815 4.95 62.12 2322.35576

EGIVEYPR CFHR3;CFHR4

complement factor H-related protein 3 isoform 2 precursor [Homo sapiens];complement factor H-related protein 4 isoform 3 precursor [Homo sapiens]

10878;10877

NP_001160096;NP_006675

1 5 262231791;117320518

N-Term(iTRAQ4plex) 1.125 9 3.7 1.079 9 6 1.114 9 6.4 1.037 9 3.2 1.234 9 7 1.158 9 2 1.11 9 1.1 42 0 2 500.73828 1.09 9.38 1000.46929

EGLCSRVSTLGLYMEANRQVPK

EIF2B3 translation initiation factor eIF-2B subunit gamma isoform 2 [Homo sapiens]

8891 NP_001160060 1 2 262205273 N-Term(iTRAQ4plex); C4(Methylthio); M14(Oxidation); K22(iTRAQ4plex)

0.918 106 13 0.874 106 11.1 0.79 106 17.1 0.901 106 5.9 0.921 106 16.5 1.04 106 5.7 1.146 106 4.1 42 0 2 532.77612 -5.79 37.34 1064.55058

EGMLSIMSYR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 6 2 38016947 N-Term(iTRAQ4plex) 1.111 28 7.9 0.974 28 7.6 1.024 28 11.5 1.048 28 6.8 1.158 28 8.5 1.215 28 7.1 1.157 28 5.7 37 3.57 0 2 583.82111 5.4 24.13 1166.63494

EGMLSIMSYR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 3 2 38016947 N-Term(iTRAQ4plex); M3(Oxidation)

0.999 9 13.8 1.177 9 21.3 1.079 9 34.9 0.935 9 10.4 1.09 9 23.5 1.042 9 17.6 1.101 9 21.7 36 6.16 0 3 1576.804 -1.78 35.77 3152.61509

EGQAVAVPSSK BNC2 zinc finger protein basonuclin-2 [Homo sapiens]

54796 NP_060107 5 1 94721327 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.207 3 6 0.883 3 2.5 1.054 3 2.8 1.165 3 9 1.245 3 3.4 1.375 3 9.5 1.185 3 0.5 34 5.24 1 3 480.28052 0.93 11.82 1438.827

EGQMESVEAAMSSK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 26 1 205277441 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.12 5 5.5 1.034 5 15.7 1.062 5 20.2 1.027 5 6.3 1.216 5 10.1 1.133 5 5.5 1.145 5 0.7 30 3.07 0 2 635.30206 -7.03 15.87 1269.60552

EGQMESVEAAMSSK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 8 1 205277441 N-Term(iTRAQ4plex); M11(Oxidation); K14(iTRAQ4plex)

1.167 2 0.2 0.998 2 10.2 1.21 2 17.3 1.212 2 7 1.116 2 7.5 1.118 2 17.8 0.923 2 25 6.32 1 4 760.59894 5.59 27.86 3039.37392

EGQMESVEAAMSSK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 2 1 205277441 N-Term(iTRAQ4plex); M4(Oxidation); M11(Oxidation); K14(iTRAQ4plex)

0.65 1 0.891 1 0.597 1 0.67 1 0.632 1 0.71 1 1.059 1 3.96 0 3 464.92307 2.3 20.18 1392.75464

EGVIHFLELYETK TARBP1 probable methyltransferase TARBP1 [Homo sapiens]

6894 NP_005637 1 1 110825988 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.701 1 0.824 1 1.447 1 1.756 1 1.655 1 2.008 1 1.143 1 3.59 2 3 806.12726 11.69 50.18 2416.36722

EGVQKEDIPPADLSDQVPDTESETR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 28 1 115298678 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.006 1 0.545 1 0.634 1 1.163 1 0.921 1 1.691 1 1.453 1 3.72 0 3 1009.4879 0.06 53 3026.44919

EGVYTVFAPTNEAFR TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex) 0.764 1 0.984 1 0.718 1 0.73 1 0.797 1 0.81 1 1.11 1 46 3.42 0 2 694.40002 -7.76 19.1 1387.79277

EGWIHTVCINGR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 3 1 62739186 N-Term(iTRAQ4plex); C8(Methylthio)

1.552 1 1.008 1 1.418 1 1.407 1 1.699 1 1.685 1 1.198 1 41 4.62 0 3 710.37396 -3.98 58.54 2129.10733

EHAVEGDCDFQLLK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 373 1 156523970 N-Term(iTRAQ4plex); C8(Methylthio); K14(iTRAQ4plex)

1.605 1 1.034 1 1.518 1 1.468 1 1.747 1 1.69 1 1.151 1 40 3.32 0 2 611.37402 -3.11 32.83 1221.74077

EHEGAIYPDNTTDFQR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 4 1 4557485 N-Term(iTRAQ4plex) 1.53 1 0.834 1 1.333 1 1.598 1 1.473 1 1.766 1 1.105 1 39 3.33 0 2 773.95856 0.96 28.4 1546.90984

Page 11: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

EHIVDLEMLTVSSIGTFR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 10 1 86788015 N-Term(iTRAQ4plex) 1.123 1 0.976 1 1.055 1 1.081 1 1.165 1 1.193 1 1.104 1 5.08 0 3 648.34027 -2.61 20.29 1943.00626

EHIVDLEMLTVSSIGTFR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 2 1 86788015 N-Term(iTRAQ4plex); M8(Oxidation)

1.388 1 1.085 1 1.334 1 1.23 1 1.559 1 1.437 1 1.168 1 4.09 1 3 833.44244 -1.45 40.5 2498.31278

EHLLMALADLDELLIR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 8 1 126012571 N-Term(iTRAQ4plex) 1.27 1 0.874 1 1.102 1 1.261 1 1.278 1 1.462 1 1.16 1 135 6.34 0 2 849.49402 1.09 20.67 1697.98076

EHLLMALAGIDTLLIR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 4 1 126012571 N-Term(iTRAQ4plex) 1.28 1 1.002 1 1.18 1 1.178 1 1.382 1 1.379 1 1.171 1 105 8.29 0 3 979.11707 0.98 57.02 2935.33664

EHLVQATPENLQEAR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 27 1 133925809 N-Term(iTRAQ4plex) 1.142 2 14.7 0.828 2 4.6 1 2 18.5 1.207 2 13.8 1.088 2 15.3 1.314 2 10.7 1.088 2 3.1 96 5.62 0 3 876.87335 -0.73 24.07 1752.73862

EHSSLAFWK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 1 1 153266841 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.332 3 20.9 1.068 3 5.8 1.289 3 17.6 1.16 3 13.6 1.523 3 18 1.371 3 24 1.182 3 0.3 85 5.1 0 3 946.51343 -1.51 56.43 1892.02494

EHVTVYLGLHDVR MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 4 1 21264359 N-Term(iTRAQ4plex) 1.127 1 1.007 1 1.036 1 1.028 1 1.226 1 1.217 1 1.183 1 82 5.65 0 2 809.47314 -1.5 31.06 1617.93901

EIEASK MRPL19 39S ribosomal protein L19, mitochondrial [Homo sapiens]

9801 NP_055578 1 1 94557305 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.927 2 1 1.005 2 9 0.853 2 2.9 0.848 2 6.1 1.007 2 4 1.002 2 5 1.181 2 1.1 79 4.62 0 2 892.36426 1.71 68.7 1783.72124

EIEEVLTPEMLMR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 11 1 21361302 N-Term(iTRAQ4plex) 1.123 2 19.4 1.003 2 4.9 1.063 2 12.4 1.06 2 17.3 1.186 2 21.1 1.182 2 26.1 1.115 2 8.5 77 4.72 0 2 738.90106 1.4 36.23 1476.79485

EIEEVLTPEMLMR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 10 1 21361302 N-Term(iTRAQ4plex); M12(Oxidation)

1.123 1 1.045 1 1.055 1 1.01 1 1.241 1 1.187 1 1.176 1 74 5.21 0 3 506.27966 1.7 20.21 1516.82444

EIEEVLTPEMLMR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 2 1 21361302 N-Term(iTRAQ4plex); M10(Oxidation); M12(Oxidation)

1.347 2 10.2 1.022 2 9.7 1.307 2 1.6 1.279 2 11.3 1.417 2 8.7 1.386 2 18.6 1.084 2 7.2 73 4.03 0 2 1050.4434 -3.42 21.33 2099.87944

EIFNMAR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex) 1.372 1 0.958 1 1.251 1 1.305 1 1.436 1 1.499 1 1.148 1 72 5.49 0 2 1054.9835 0.91 44.94 2108.95976

EIFNMAR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation)

1.45 1 1.106 1 1.303 1 1.178 1 1.751 1 1.583 1 1.344 1 72 7.92 0 3 983.79352 5.62 62.22 2949.366

EIGELYLPK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 381 1 50659080 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.371 1 0.9 1 1.222 1 1.358 1 1.383 1 1.537 1 1.132 1 66 6.14 0 2 784.9057 0.26 29.69 1568.80412

EIGGDVQK CAP1 adenylyl cyclase-associated protein 1 [Homo sapiens]

10487 NP_006358 1 1 5453595 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.418 1 0.897 1 0.947 1 1.056 1 1.741 1 1.942 1 1.838 1 63 4.3 0 3 1002.1174 -1.84 76.51 3004.33756

EIIIHQNYK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 6 1 78191798 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.02 1 0.882 1 0.947 1 1.073 1 0.974 1 1.104 1 1.028 1 59 4.24 0 2 1006.4191 -0.52 57.77 2011.83086

EILNINQK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 5 3 14550407 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.344 3 26.4 1.157 3 41.8 1.174 3 32.3 1.373 3 53.9 1.167 3 25.1 1.284 3 36.1 0.935 3 15.6 59 5.29 0 3 761.71722 -0.53 80.09 2283.14023

EILSVDCSTNNPSQAK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 48 1 355594753 N-Term(iTRAQ4plex); C7(Methylthio); K16(iTRAQ4plex)

16.965 1 0.588 1 26.672 1 45.389 1 0.263 1 0.447 1 54 7.69 0 4 914.90894 -2.5 40.81 3656.61391

EIMENYNIALR CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

196 2 118442839;62739186

N-Term(iTRAQ4plex) 1.22 4 6.9 0.958 4 5 1.185 4 5.6 1.237 4 5.6 1.207 4 8.9 1.307 4 6 1.081 4 7.6 54 7.4 0 3 725.05951 1.96 62.79 2173.16397

EIMENYNIALR CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

20 2 118442839;62739186

N-Term(iTRAQ4plex); M3(Oxidation)

1.456 3 20.9 0.968 3 8.2 1.395 3 22.8 1.347 3 12.5 1.568 3 29.2 1.514 3 18.6 1.124 3 6.1 50 4.52 0 2 775.85327 -5.5 38.01 1550.69927

EINLAPDSSSVVVSGLMVATK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

56 5 47132549;16933542

N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.225 1 1.066 1 1.173 1 1.1 1 1.358 1 1.273 1 1.157 1 49 3.5 0 2 571.7998 0.09 20.46 1142.59233

EINLAPDSSSVVVSGLMVATK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex); M17(Oxidation); K21(iTRAQ4plex)

1.57 1 0.956 1 1.495 1 1.563 1 1.576 1 1.648 1 1.054 1 49 3.28 0 2 556.79419 -0.51 10.44 1112.5811

EIPAWVPFDPAAQITK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 74 1 4502337 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.086 3 0 0.925 3 11.1 1.057 3 4.4 1.109 3 5.4 1.064 3 7.1 1.12 3 3.9 0.987 3 7.4 49 7.59 0 3 844.0437 1.07 49.88 2530.11655

EIPDEISILLLGVAHFK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 97 1 39725934 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.352 2 21.7 0.884 2 34.8 1.194 2 43.8 1.351 2 8.1 1.368 2 34.4 1.548 2 0.4 1.146 2 8.5 47 3.57 0 2 574.84662 -1.58 13.34 1148.68596

EIPVLVTQISSTNHPVK PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.353 1 0.84 1 1.147 1 1.365 1 1.344 1 1.599 1 1.172 1 45 4.02 0 3 567.65363 0.08 52.71 1700.94632

EIQIYK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.221 1 0.743 1 0.976 1 1.313 1 1.153 1 1.552 1 1.182 1 44 4.39 0 3 692.69592 -4.26 28.37 2076.07322

EIQNAVNGVK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 4 1 355594753 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.409 1 0.989 1 1.259 1 1.273 1 1.543 1 1.56 1 1.225 1 44 3.52 0 2 553.81189 8.13 25.72 1106.6165

EIQYLK ATF4 cyclic AMP-dependent transcription factor ATF-4 [Homo sapiens]

468 NP_001666 1 1 33469976 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.295 2 6.1 0.975 2 12.3 1.229 2 12 1.26 2 0.3 1.331 2 12.3 1.366 2 0 1.084 2 0.3 42 3.96 0 2 618.87469 -0.94 43.5 1236.74211

EISEVFPDQFIHLGGDEVEFK

HEXB beta-hexosaminidase subunit beta preproprotein [Homo sapiens]

3074 NP_000512 2 1 4504373 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.256 2 1.2 0.998 2 5.1 1.192 2 2.4 1.194 2 2.7 1.318 2 4.8 1.321 2 0.2 1.106 2 2.4 42 4.67 0 2 701.81396 9.86 38.43 1402.62065

EITALAPSTMK ACTB;ACTG2

actin, cytoplasmic 1 [Homo sapiens];actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

60;72 NP_001092;NP_001606

6 7 4501885;4501889

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.152 1 0.945 1 1.063 1 1.125 1 1.177 1 1.246 1 1.107 1 38 0 2 551.31927 -6.55 19.69 1101.63127

EITEKVITDIAGVIPAEK RFC4 replication factor C subunit 4 [Homo sapiens]

5984 NP_002907 1 1 4506491 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K18(iTRAQ4plex)

1.335 2 8.3 0.908 2 6 1.225 2 11.6 1.348 2 5.6 1.323 2 10.7 1.457 2 4.7 1.081 2 0.9 38 2.83 0 2 591.32501 -0.69 23.76 1181.64311

EITVIAR TMEFF1 tomoregulin-1 precursor [Homo sapiens]

8577 NP_003683 1 2 29568105 N-Term(iTRAQ4plex) 1.541 1 0.809 1 1.259 1 1.556 1 1.529 1 1.89 1 1.215 1 38 7.47 0 4 592.81915 1.64 49.97 2368.25478

EKAEAQAQYSAAVAK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

31 2 31542984;262050538

N-Term(iTRAQ4plex); K2(iTRAQ4plex); K15(iTRAQ4plex)

1.491 2 1.5 0.937 2 11 1.355 2 5.1 1.447 2 5.9 1.535 2 8.4 1.639 2 2.6 1.133 2 3.2 36 4.19 0 2 702.88513 -0.99 52.88 1404.7675

EKGEIQNILQK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 2 1 78191798 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex)

1.917 2 49.3 1.7 2 154.4 2.201 2 219.9 1.295 2 22.7 3.288 2 139.6 1.935 2 6.4 1.494 2 29.4 8.41 0 4 1014.7272 0.89 52.97 4055.88686

EKIDPLEVEEGDPIVLPCNPPK

CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C18(Methylthio); K22(iTRAQ4plex)

1.429 1 0.695 1 1.104 1 1.588 1 1.319 1 1.898 1 1.195 1 6.02 0 4 851.4079 2.04 45.51 3402.60976

EKLQDEDLGFL CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 47 1 67782358 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.616 1 0.942 1 1.433 1 1.522 1 1.705 1 1.81 1 1.19 1 4.82 0 3 598.30304 -0.54 33.15 1792.89457

EKPQSTISGLLGPTLYAEVGDIIK

F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 5 1 105990535 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K24(iTRAQ4plex)

1.232 1 1.019 1 1.207 1 1.184 1 1.281 1 1.257 1 1.061 1 2.77 0 2 657.89551 -1.89 50.8 1314.78374

EKVSQLDIQIK EEA1 early endosome antigen 1 [Homo sapiens]

8411 NP_003557 1 1 55770888 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex)

0.847 2 11 1.05 2 22.3 0.767 2 1 0.73 2 23.3 0.974 2 1.3 0.928 2 21 1.27 2 2.3 63 4.65 0 2 730.86823 -0.6 39.82 1460.72246

ELAAQTIK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 12 2 156119625 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.008 1 0.738 1 0.919 1 1.245 1 0.833 1 1.129 1 0.906 1 41 4.15 0 3 523.93823 0.75 18.35 1569.80014

ELANEIR ARHGAP35 rho GTPase-activating protein 35 [Homo sapiens]

2909 NP_004482 XP_933778 XP_946345

2 1 150417981 N-Term(iTRAQ4plex) 0.791 2 5.1 0.866 2 44.1 0.713 2 62.8 0.824 2 15.6 0.742 2 7.1 0.857 2 52.3 1.04 2 72.1 38 5.93 1 4 639.60455 -1.55 63.62 2555.39638

ELDATPRMTIPYEELSGTRHFK

SEMA4G semaphorin-4G isoform 2 precursor [Homo sapiens]

57715 NP_001190173 1 2 322302953 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.238 1 0.568 1 0.857 1 1.509 1 1.084 1 1.908 1 1.264 1 2.79 1 2 684.87933 8.63 18.46 1368.75139

ELDESLQVAER CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 101 1 355594753 N-Term(iTRAQ4plex) 1.036 1 0.678 1 0.706 1 1.041 1 1.032 1 1.521 1 1.461 1 2.89 0 2 829.44824 0.85 40.65 1657.88921

ELDPMDVR NOTCH1 neurogenic locus notch homolog protein 1 preproprotein [Homo sapiens]

4851 NP_060087 1 1 148833508 N-Term(iTRAQ4plex) 1.713 1 1.321 1 2.135 1 1.616 1 1.841 1 1.394 1 0.862 1 4.56 0 4 818.70233 15.27 57.59 3271.7875

ELDRDTVFALVNYIFFK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 5 1 189163538 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.384 1 1.133 1 1.221 1 1.077 1 1.732 1 1.529 1 1.419 1 3.55 0 3 814.43396 6.11 47.14 2441.28733

ELDSTGTPTGK CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 6 1 166362713 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.259 30 6.1 0.906 30 14.5 1.134 30 13.1 1.254 30 11.9 1.308 30 13.6 1.391 30 11.9 1.114 30 14.4 129 8.22 0 3 1074.5635 1.41 53.76 2148.11968

ELEAQEARK PAF1 RNA polymerase II-associated factor 1 homolog isoform 2 [Homo sapiens]

54623 NP_001243755 1 2 378744165 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.232 133 14.3 0.884 133 12.9 1.085 133 19.9 1.191 133 18.7 1.22 133 17.5 1.398 133 14.7 1.14 133 12.4 120 8.4 0 3 1231.1481 1.4 66.5 2461.29563

ELEEIVQPIISK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 3 1 16507237 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.017 12 29.4 0.939 12 34.8 0.955 12 9.9 1.173 12 29.6 0.97 12 66.9 1.08 12 6.5 0.913 12 58.4 101 9.3 0 3 1383.7089 -0.56 80.21 4149.11203

ELELQIGNALFIGK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 3 1 205277441 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.234 48 14.1 0.965 48 9.1 1.16 48 18.3 1.161 48 14.3 1.275 48 18.5 1.321 48 10 1.129 48 10.5 101 8.56 0 3 1075.5523 -6.48 24.26 2150.09722

ELENALK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 2 2 45580688 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.297 78 15.1 0.947 78 21.3 1.189 78 18.1 1.237 78 18.8 1.304 78 21.2 1.373 78 24 1.13 78 15.7 99 9.89 0 3 1000.4627 1.99 47.01 2999.36954

ELEVAIR FUCA2 plasma alpha-L-fucosidase precursor [Homo sapiens]

2519 NP_114409 2 1 40068512 N-Term(iTRAQ4plex) 1.212 99 11.3 0.958 99 10.1 1.115 99 13.6 1.167 99 15.8 1.285 99 14.9 1.299 99 12.5 1.125 99 9.7 99 5.78 0 2 879.50085 0.93 43.02 1757.99077

ELGCGAASGTPSGILYEPPAEK

CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 2 1 5174411 N-Term(iTRAQ4plex); C4(Methylthio); K22(iTRAQ4plex)

1.145 109 9.3 0.991 109 11 1.076 109 11.7 1.119 109 11.8 1.181 109 13.2 1.219 109 12.6 1.097 109 8.2 98 5.69 0 2 925.55548 0.36 73.94 1850.10234

ELGICPDDAAVIPIK PIP prolactin-inducible protein precursor [Homo sapiens]

5304 NP_002643 2 1 4505821 N-Term(iTRAQ4plex); C5(Methylthio); K15(iTRAQ4plex)

1.513 6 6.6 0.975 6 9.9 1.503 6 9.6 1.484 6 5.7 1.604 6 15.4 1.624 6 11.4 1.099 6 4.7 96 6.57 0 3 1089.5765 -0.45 28.44 2178.13895

ELISLVEDVSSNYDGCCEGDVVQCIR

AFM afamin precursor [Homo sapiens] 173 NP_001124 7 1 4501987 N-Term(iTRAQ4plex); C16(Methylthio); C17(Methylthio); C24(Methylthio)

1.475 13 11.6 0.928 13 20.5 1.375 13 13 1.358 13 14.5 1.486 13 14.6 1.546 13 16.1 1.183 13 13.7 96 6.9 0 3 1159.0892 2.42 61.86 2317.17119

ELISNASDALDK HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 3 2 4507677 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.214 22 4.8 0.983 22 8.8 1.104 22 12.2 1.145 22 7.7 1.264 22 11.7 1.332 22 12 1.133 22 7.8 86 5.47 0 3 512.28131 -3.43 25.99 1534.82938

ELKEQQDSPGNK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 2 2 115583663 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K12(iTRAQ4plex)

1.275 19 11.9 0.914 19 14.2 1.155 19 11.9 1.263 19 17.2 1.288 19 15.1 1.359 19 14.8 1.121 19 9.5 86 7.77 0 3 1320.2074 0.1 41.77 2639.40752

ELLALIQLER ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 6 2 221316614 N-Term(iTRAQ4plex) 1.334 13 13.2 1.064 13 33.2 1.294 13 16.1 1.318 13 24.6 1.435 13 18.5 1.403 13 22.3 1.137 13 16.7 84 8.62 0 3 1102.5204 -4.96 75.14 3305.56411

ELLDTVTAPQK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 12 1 39725934 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.392 8 7 1.013 8 20.8 1.242 8 12.4 1.247 8 16.1 1.461 8 4.5 1.445 8 17.4 1.164 8 6.8 84 6.24 0 3 910.98425 -0.63 51.65 1820.96427

ELLESYIDGR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 33 1 4503635 N-Term(iTRAQ4plex) 1.159 23 10.7 0.906 23 17.2 1.048 23 16.6 1.158 23 11.7 1.121 23 14.7 1.275 23 10.9 1.12 23 5.2 82 4.92 0 2 651.36761 -1.15 19.78 1301.726

ELLETVVNR APOC4 apolipoprotein C-IV precursor [Homo sapiens]

346 NP_001637 3 1 4502161 N-Term(iTRAQ4plex) 1.221 36 13.5 0.937 36 11.8 1.186 36 12.6 1.181 36 12.6 1.235 36 15.9 1.298 36 10.3 1.081 36 10.6 82 6.73 0 3 1159.0892 2.42 61.86 2301.17266

ELLLDLAK INHBC inhibin beta C chain preproprotein [Homo sapiens]

3626 NP_005529 2 1 5031795 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.191 23 6.1 1.025 23 10.8 1.134 23 10.8 1.118 23 9.5 1.253 23 10.5 1.212 23 8.8 1.092 23 6.2 80 7.78 0 3 1089.5765 -0.45 28.44 2162.1608

ELLLEHQDAYQAGIVFPDCFYPSICK

GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 16 2 29171717 N-Term(iTRAQ4plex); C19(Methylthio); C25(Methylthio); K26(iTRAQ4plex)

1.081 9 9.4 0.799 9 17.4 0.842 9 11.1 1.053 9 12.5 1.189 9 14.7 1.335 9 18 1.209 9 23.2 79 9.82 1 3 1091.1884 -4.32 36.08 3271.55051

ELLSQGATLSGWYHLCLPEGR

FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 41 2 27754776 N-Term(iTRAQ4plex); C16(Methylthio)

1.939 16 25.1 1.075 16 21.3 1.756 16 18.1 1.816 16 17.1 2.209 16 18.7 2.044 16 29.8 1.233 16 9 79 8.32 0 3 1102.5204 -4.96 75.14 3321.56137

ELLTQPGDWTLFVPTNDAFK

POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 1 4 209863034 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.021 4 5.7 0.936 4 6.7 0.978 4 11.5 1.116 4 14.7 1.016 4 11.6 1.173 4 16.4 1.051 4 7.9 78 6.3 0 3 1713.8827 -0.87 31.45 3426.74851

ELNQAGQETLVTGWGYHSSR

PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 4 1 4506115 N-Term(iTRAQ4plex) 1.264 54 9.2 0.96 54 7.9 1.129 54 10 1.215 54 11.8 1.3 54 8.1 1.371 54 9.8 1.131 54 5.7 78 5.58 0 2 807.91455 -1.62 36.09 1614.82683

ELPEHTVK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 11 2 32483410 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.212 63 8.7 0.962 63 11.1 1.126 63 10.3 1.198 63 7.1 1.254 63 11.4 1.329 63 8.5 1.127 63 4.9 77 4.2 0 2 724.91418 -1.98 43.18 1448.82109

ELPPHLGELTVAEETSSSLR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 1 188528648 N-Term(iTRAQ4plex) 0.914 8 19.8 1.046 8 2.7 0.871 8 14.9 0.884 8 21.4 0.99 8 20.1 0.961 8 17.5 1.131 8 5.9 74 5.52 0 2 781.93616 3.01 19.35 1562.86504

ELPQSIVYK EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 8 1 86788015 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.427 2 35.6 0.867 2 9.4 1.284 2 37.2 1.481 2 47.8 1.38 2 25.1 1.592 2 35.1 1.075 2 11.3 73 7.59 0 3 1000.4627 1.99 47.01 3015.36399

ELQAAQAR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 7 1 4557325 N-Term(iTRAQ4plex) 1.198 63 9.5 0.972 63 8.9 1.103 63 13.1 1.131 63 10.3 1.262 63 9.5 1.277 63 12.9 1.109 63 8.8 71 4.35 0 2 790.93298 -0.04 73.09 1580.86003

ELQETNAALQDVR COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 4 1 40217843 N-Term(iTRAQ4plex) 2.064 1 0.869 1 1.724 1 1.983 1 2.134 1 2.456 1 1.238 1 70 6.3 1 3 525.31281 -1.66 14.2 1573.92386

ELQGQIEEK SPTBN4 spectrin beta chain, brain 3 isoform sigma5 [Homo sapiens]

57731 NP_079489 2 2 115430239 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.237 42 8.4 1.007 42 15.3 1.165 42 15.4 1.167 42 10 1.337 42 11.5 1.321 42 9 1.123 42 7.1 68 4.25 0 2 689.40112 -2.25 24.22 1377.79326

ELRPWCFTTDPNK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 4 1 4505881 N-Term(iTRAQ4plex); C6(Methylthio); K13(iTRAQ4plex)

1.287 6 69.8 0.782 6 29.3 1.17 6 73.6 1.125 6 58.9 1.417 6 56 1.44 6 20.9 1.213 6 28.1 65 8.76 1 3 1178.9038 4.63 60.96 3534.69687

ELRPWCFTTDPNKR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 2 1 4505881 N-Term(iTRAQ4plex); C6(Methylthio); K13(iTRAQ4plex)

0.763 3 12 0.844 3 11.5 0.713 3 25.1 0.899 3 2.3 0.829 3 3.3 0.885 3 10.1 0.985 3 12.4 63 8.02 0 4 1151.583 11.75 35.25 3452.73476

ELSEALGQIFDSQR LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 4 1 5031863 N-Term(iTRAQ4plex) 1.571 3 10.3 0.512 3 38 1.024 3 20.3 2 3 13.1 1.304 3 25.5 1.889 3 19.6 0.944 3 6.3 62 5.2 0 3 1383.7089 -0.56 80.21 4165.10483

ELSEPTMYHTGDFEEWTR RELN reelin isoform b precursor [Homo sapiens]

5649 NP_774959 1 2 27436940 N-Term(iTRAQ4plex) 1.222 6 8.3 0.887 6 28.9 1.067 6 23.8 1.203 6 6.9 1.21 6 19 1.366 6 9 1.134 6 4 57 3.76 0 2 581.35925 2.63 15.25 1161.70806

ELSHLPSLYDYSAYR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 31 1 45580688 N-Term(iTRAQ4plex) 1.408 1 0.939 1 1.299 1 1.384 1 1.43 1 1.523 1 1.101 1 54 0 2 790.93298 -0.04 73.09 1596.85625

ELSSFIDK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 280 2 32483410 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

2.252 3 13.4 1.163 3 68.3 2.86 3 36.7 2.458 3 2.3 2.243 3 12.3 2.693 3 2.5 1.078 3 4.8 53 6.69 0 3 1102.5204 -4.96 75.14 3337.54905

ELSYMVVSR CD109 CD109 antigen isoform 3 precursor [Homo sapiens]

135228 NP_001153060 2 3 227430303 N-Term(iTRAQ4plex) 1.563 3 0.3 0.976 3 3.6 1.393 3 2.9 1.427 3 9.8 1.604 3 0.2 1.685 3 4.5 1.173 3 5.4 53 5.18 0 3 781.93616 3.01 19.35 1578.85874

ELSYYSLEDLNNK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 34 2 38016947 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.322 1 0.995 1 2.152 1 2.162 1 2.481 1 2.493 1 1.153 1 42 6.99 1 4 1091.1884 -4.32 36.08 3287.54873

ELTLEDLK CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 10 1 4557417 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.317 2 12.9 0.795 2 9.8 1.152 2 14.9 1.449 2 24.9 1.21 2 2.5 1.523 2 12.4 1.051 2 12.3 33 4.63 0 3 461.23056 0.56 7.75 1381.67594

ELTPQVVSAAR VCL vinculin isoform VCL [Homo sapiens]

7414 NP_003364 2 2 4507877 N-Term(iTRAQ4plex) 1.423 1 1.087 1 1.394 1 1.281 1 1.577 1 1.451 1 1.132 1 32 0 2 446.78217 8.49 16.29 892.55705

ELTTEIDNNIEQISSYK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

8 2 195972866 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

2.011 1 0.927 1 1.782 1 1.923 1 2.092 1 2.257 1 1.174 1 32 5.34 0 3 1713.8827 -0.87 31.45 3442.73764

ELVLAGNR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 3 2 4826772 N-Term(iTRAQ4plex) 1.101 2 15.2 0.807 2 22.2 0.891 2 28.1 1.104 2 5.6 1.103 2 23.1 1.366 2 0.8 1.238 2 4.8 31 0 2 492.26813 1.15 28.76 983.52898

ELWILNR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 1 1 157266300 N-Term(iTRAQ4plex) 1.022 2 15.7 1.278 2 9.4 0.969 2 4.9 0.758 2 14.3 1.36 2 14.3 1.064 2 23.9 1.404 2 9.3 9.32 0 4 802.40717 3.96 60.73 3206.60683

EMECAGTYDGSIDACK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 62 1 119392081 N-Term(iTRAQ4plex); C4(Methylthio); C15(Methylthio); K16(iTRAQ4plex)

1.693 1 75.1 1 0.718 1 0.991 1 1.38 1 7.14 1 5 745.79138 9.9 31.04 3724.9278

EMECAGTYDGSIDACK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 4 1 119392081 N-Term(iTRAQ4plex); M2(Oxidation); C4(Methylthio); C15(Methylthio); K16(iTRAQ4plex)

1.446 2 17.2 0.956 2 12.2 1.374 2 22.1 1.437 2 9.7 1.456 2 24.5 1.522 2 12 1.059 2 2.3 6.98 0 4 802.40717 3.96 60.73 3222.59951

EMMQTAMQNTMLINGIAQVTFDSETAVK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

2.557 1 0.915 1 1.642 1 1.796 1 4.78 0 5 1713.8827 -0.87 31.45 3458.72663

EMSGSPASGIPVK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

50 6 178557739;67190748

N-Term(iTRAQ4plex); K13(iTRAQ4plex)

32 0 2 407.23798 -2.72 8.47 813.47038

EMSGSPASGIPVK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

N-Term(iTRAQ4plex); M2(Oxidation); K13(iTRAQ4plex)

1.468 1 0.77 1 1.261 1 1.638 1 1.337 1 1.736 1 1.06 1 3.87 2 3 752.73743 -11.4 48.49 2256.19773

ENADSLQASLRPHADELK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 10 1 71773110 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

0.37 1 1.364 1 0.425 1 0.312 1 0.448 1 0.329 1 1.054 1 68 3.73 0 2 811.93054 -7.65 16.73 1622.85381

ENAGEDPGLAR DCD dermcidin preproprotein [Homo sapiens]

117159 NP_444513 4 1 16751921 N-Term(iTRAQ4plex) 1.264 1 0.752 1 0.865 1 1.149 1 1.35 1 1.794 1 1.561 1 44 0 2 777.36029 0.32 77.97 1553.7133

ENEGFTVTAEGK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 17 1 115298678 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.874 32 12.1 0.911 32 13 0.771 32 13.4 0.853 32 14.5 0.914 32 19.8 0.984 32 9.9 1.187 32 11.7 116 7.27 0 3 1113.0625 -3.47 21.88 2225.11772

ENFAGEATLQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 39 1 105990532 N-Term(iTRAQ4plex) 1.471 24 22.4 0.904 24 18.9 1.371 23 25.1 1.401 23 26.2 1.525 24 28.1 1.631 24 32.4 1.077 23 14.3 108 7.19 0 3 1113.0625 -3.47 21.88 2241.11675

ENFLFLTPDCK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

137 2 4504893;156231037

N-Term(iTRAQ4plex); C10(Methylthio); K11(iTRAQ4plex)

1.053 193 8 0.97 193 8.7 0.967 193 12.6 0.992 193 11.8 1.109 193 9.8 1.146 193 11.6 1.151 193 8.1 102 6.76 0 3 969.47443 3.9 33.04 1937.93808

ENFVLTTAK PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 2 2 4506121 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.926 22 26.8 0.918 22 12.5 0.851 20 18.1 0.932 20 25.8 1.017 22 27.4 1.073 22 23.4 1.12 20 9.1 101 7.36 0 3 1075.0714 -1.12 29.95 2149.13555

ENGYECEWR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C6(Methylthio)

1.26 87 37.6 0.943 85 35.7 1.095 86 26.9 1.058 83 30.7 1.287 87 42.5 1.304 85 41.4 1.057 86 32.9 88 9.98 0 4 1214.2485 3.6 74.79 3640.73891

ENIQDNISLFSLGMGFDVDYDFLK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 12 1 70778918 N-Term(iTRAQ4plex); M14(Oxidation); K24(iTRAQ4plex)

1.137 347 16.4 1.003 347 20.3 1.06 347 20.2 1.057 347 20.6 1.192 347 19.3 1.208 347 22.1 1.136 347 16.6 88 6.99 0 3 1428.7476 3.91 60.66 2856.48703

ENLLDFIK P4HB protein disulfide-isomerase precursor [Homo sapiens]

5034 NP_000909 4 1 20070125 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.066 7 1.9 0.913 7 8 0.955 7 9 1.003 7 4.3 1.138 7 5.5 1.189 7 8.2 1.185 7 5.5 82 4.78 0 3 742.9223 4.16 15.38 1484.83609

ENPAVIDFELAPIVDLVR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 27 1 169636415 N-Term(iTRAQ4plex) 1.085 45 6.6 0.966 45 18.3 0.968 45 14.8 1.036 44 11.2 1.142 44 10.2 1.191 44 13.2 1.177 44 16.4 74 10.33 0 4 1270.9711 3.83 81.61 3810.89865

ENPLTQAVPK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 4 1 45580688 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.383 12 13.4 0.925 12 6.5 0.349 12 10.1 0.381 12 21.2 0.399 12 17.7 0.425 12 24.3 1.121 12 2.6 67 4.6 0 2 735.80042 -1.52 16.85 1470.59526

ENQLEVLEVSWLHGLK LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 62 1 16418467 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.707 1 0.958 1 0.663 1 0.692 1 0.721 1 0.753 1 1.088 1 56 4.19 1 2 871.90125 1.37 14.83 1742.79521

ENSQYQPIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 6 2 38016947 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.981 24 13.3 0.974 24 17.7 0.888 24 25.2 0.957 24 10.1 0.991 24 21.3 1.098 24 11.6 1.139 24 3.6 56 3.05 0 2 551.3288 -3.95 17.77 1101.65007

ENTVTNDWIPEGEEDDDYLDLEK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 8 1 73858566 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.075 25 9.3 0.852 25 30.1 0.929 25 23.6 0.98 25 9 1.114 25 18.9 1.143 25 9.8 1.162 25 4.5 55 3.26 0 2 504.28458 0.69 2.25 1007.56218

ENYLLPEAK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 2 1 13540563 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.216 8 7.7 0.955 8 1.8 1.124 8 7 1.172 8 7.3 1.253 8 6.6 1.333 8 7.9 1.119 8 2.6 44 0 2 456.79749 0.84 9.4 912.58769

ENYPLPWEK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 8 2 29171717 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1 142 5.5 1.058 142 6.1 0.976 142 7.1 0.913 142 6.6 1.092 142 7.6 1.031 142 6.3 1.122 142 3.3 41 3.45 0 2 562.80499 -1.72 7.25 1124.60588

EPAPTTPK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 2 4 189181722 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.846 4 22.4 1.149 4 8.8 0.751 4 43.7 0.867 4 4.2 0.833 4 40.4 0.969 4 10.8 1.118 4 5.2 38 0 2 540.26666 0.38 18.82 1079.52776

Page 12: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

EPCVESLVSQYFQTVTDYGK

APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 236 1 4502149 N-Term(iTRAQ4plex); C3(Methylthio); K20(iTRAQ4plex)

1.041 6 7 0.895 6 10.3 0.905 6 11.3 1.008 6 4.2 1.061 6 14.4 1.143 6 3.8 1.145 6 2.8 37 0 2 468.78488 2.19 11.55 936.56249

EPEEVATCVGR MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 3 1 71274107 N-Term(iTRAQ4plex); C8(Methylthio)

1.478 1 1.167 1 1.56 1 1.337 1 1.643 1 1.408 1 1.053 1 3.89 1 3 657.01624 -5.97 23.19 1969.03415

EPFEEK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 1 1 41393602 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.687 1 1.148 1 1.778 1 1.549 1 1.845 1 1.608 1 1.038 1 4.39 2 4 745.39868 -0.58 54.68 2978.5729

EPFLSCCQFAESLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

143 6 178557739;67190748

N-Term(iTRAQ4plex); C6(Methylthio); C7(Methylthio)

1.616 5 16.7 1.096 5 16.4 1.606 5 28.9 1.506 5 4 1.78 5 37.1 1.624 5 12.6 1.108 5 4.3 129 7.8 0 3 1117.5574 2.11 34.35 2234.10056

EPFVPILK FZD5 frizzled-5 precursor [Homo sapiens] 7855 NP_003459 1 1 27894385 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.61 2 2.7 0.734 2 5.6 1.35 2 2.9 1.841 2 8.5 1.44 2 2.1 1.964 2 3.5 1.067 2 5 116 7.44 0 3 1335.7195 0.85 81.09 2670.4235

EPGLCTWQSLR TIMP1 metalloproteinase inhibitor 1 precursor [Homo sapiens]

7076 NP_003245 2 1 4507509 N-Term(iTRAQ4plex); C5(Methylthio)

1.392 17 17.8 0.899 17 21.9 1.279 17 24.6 1.431 17 15 1.412 17 20.1 1.612 17 22.1 1.153 17 11.5 112 8.44 0 3 1513.3295 6.24 70.42 3025.64591

EPGQDLVVLPLSITTDFIPSFR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 18 1 115298678 N-Term(iTRAQ4plex) 1.035 3 21.2 1.29 3 17.1 1.013 3 12.9 0.764 3 17.7 1.13 3 35.7 0.987 3 57.8 1.116 3 19.4 111 7.3 0 3 1335.7195 0.85 81.09 2654.44718

EPLGPALAHELR SELENBP1 selenium-binding protein 1 [Homo sapiens]

8991 NP_003935 2 1 16306550 N-Term(iTRAQ4plex) 1.591 11 10 1.103 11 11.2 1.497 11 14.2 1.372 11 7.9 1.761 11 11.6 1.528 11 7.4 1.121 11 1.4 101 5.55 0 2 817.90747 -2.71 25.33 1634.81804

EPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGR

AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 3 1 4557287 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.503 17 13.2 0.976 16 19.9 1.292 16 25.1 1.351 15 20 1.645 17 16.6 1.579 16 24 1.234 15 15.4 100 8.89 0 3 1330.5997 -1.08 34.36 2660.19219

EPTMYVGSTSVQTSR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 28 1 41393602 N-Term(iTRAQ4plex) 1.332 29 19.3 0.86 29 24.3 1.188 29 28 1.386 29 26 1.369 29 24.3 1.65 29 20.3 1.13 29 21.8 98 8.55 0 3 1067.1588 3.26 56.49 3199.44944

EPTMYVGSTSVQTSR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 13 1 41393602 N-Term(iTRAQ4plex); M4(Oxidation)

1.472 12 8.7 0.894 12 13.4 1.313 12 19.7 1.42 12 10 1.49 12 14.6 1.602 12 10.2 1.147 12 8 96 6.68 0 3 626.64392 0.67 41.03 1877.91245

EPVPMLPASLCQDVLSLLPGR

HELZ2 peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein isoform 2 [Homo sapiens]

85441 NP_208384 XP_114156

1 2 156105695 N-Term(iTRAQ4plex); M5(Oxidation); C11(Methylthio)

1.017 12 32.8 0.929 12 64.7 1.002 12 80.7 1.106 12 66.2 0.991 12 29.3 1.023 12 43.2 1.127 12 42.6 95 9.71 1 4 1469.8392 0.13 80.17 2938.67119

EQAPNLVYMVTGNPASDEIK

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.488 8 11.4 1.01 8 65.3 1.67 8 22.3 1.346 8 27.5 1.783 8 20.5 1.336 8 27.9 0.995 8 28.5 93 10.08 0 3 928.19531 0.61 81.08 2782.57138

EQFLDGDGWTSR CALR calreticulin precursor [Homo sapiens]

811 NP_004334 2 1 4757900 N-Term(iTRAQ4plex) 2.129 6 25 0.736 6 33.6 1.706 6 23.3 2.05 6 16.5 1.929 6 28.5 2.342 6 34.9 1.238 6 8.9 89 6.13 0 3 1123.917 6.09 54.54 3369.73642

EQGNLESGGQNRVAR ZNF407 zinc finger protein 407 isoform 3 [Homo sapiens]

55628 NP_001139662 1 3 226246537 N-Term(iTRAQ4plex) 1.5 10 16.9 1.155 10 29.3 1.432 10 28 1.24 10 35.4 1.653 10 32.2 1.5 10 35.4 1.202 10 19.6 89 7.34 0 3 1123.917 6.09 54.54 3353.74106

EQHLFLPFSYK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 20 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.365 4 51.2 0.857 4 17 1.204 4 55.2 1.463 4 52.4 1.284 4 49.1 1.706 4 27.7 1.031 4 17.4 82 8.77 0 3 882.83051 4.21 80.69 2646.47696

EQLELLK SUN3 SUN domain-containing protein 3 [Homo sapiens]

256979 NP_689995 2 1 71834868 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.187 2 0.6 1.125 2 32.4 1.26 2 24.3 1.12 2 7.7 1.273 2 8.5 1.132 2 23.4 1.011 2 15.5 81 7.53 0 3 882.83051 4.21 80.69 2630.47666

EQLGEFYEALDCLR ORM1 alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5004 NP_000598 4 1 167857790 N-Term(iTRAQ4plex); C12(Methylthio)

1.606 12 9.5 0.982 12 9 1.45 12 13.4 1.512 12 7.3 1.655 12 12.7 1.738 12 6.1 1.146 12 2.9 72 5.29 0 3 542.59851 1.55 54.01 1625.78318

EQLGPVTQEFWDNLEK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 4 1 4557321 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.32 7 18.2 0.916 7 4.6 1.18 7 16.4 1.308 7 14.8 1.46 7 18.1 1.546 7 12.5 1.164 7 22.6 60 4.77 0 4 848.4928 0.45 23.76 1695.96865

EQLSLLDR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 70 1 50659080 N-Term(iTRAQ4plex) 1.202 19 12.5 0.938 19 13.2 1.127 19 15.3 1.236 19 34.4 1.207 19 11 1.306 19 24.5 1.053 19 13.6 40 7.66 0 4 797.92285 4.68 65.82 3188.66958

EQLTPLIK APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 14 1 4502149 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.189 2 10.2 0.963 2 7.2 1.111 2 15.3 1.153 2 8.1 1.224 2 12.3 1.271 2 5.1 1.102 2 3 36 0 2 387.25943 -1.01 8.75 773.5114

EQPGVYTK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 11 1 78191798 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.416 1 1.037 1 1.391 1 1.341 1 1.493 1 1.44 1 1.073 1 35 0 2 611.86908 1.89 28.67 1222.73088

EQPPSLTR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 1 1 145275213 N-Term(iTRAQ4plex) 1.33 3 1.5 0.933 3 10.1 1.23 3 7.6 1.318 3 2.5 1.341 3 9.3 1.506 3 4.5 1.12 3 4 32 3.17 0 2 576.28693 -0.35 34.13 1151.5623

EQQALQTVCLK CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 13 1 156627579 N-Term(iTRAQ4plex); C9(Methylthio); K11(iTRAQ4plex)

1.228 2 1.6 0.972 2 0.3 1.148 2 0.8 1.181 2 1.1 1.274 2 2 1.311 2 2.3 1.109 2 1.2 19 0 2 428.19135 -0.22 11.56 855.37541

EQQCVIMAENR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 43 3 4505881 N-Term(iTRAQ4plex); C4(Methylthio)

1.584 4 23 1.005 4 30.2 1.802 4 11.2 1.583 4 22.9 1.873 4 6.6 1.616 4 26.6 1.061 4 12 99 7.06 0 3 1193.5914 4.7 34.3 2386.17716

EQQCVIMAENR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 18 3 4505881 N-Term(iTRAQ4plex); C4(Methylthio); M7(Oxidation)

0.721 7 20.3 1.034 7 18.2 0.72 7 28.4 0.692 7 5.7 0.843 7 39.2 0.79 7 12.1 1.107 7 6.7 88 5.74 0 2 797.92963 -0.99 26.65 1594.84831

EQQDSPGNK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 6 2 115583663 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.814 9 14 1.018 9 14.2 0.748 9 25.3 0.738 9 23.4 0.889 9 20.8 0.977 9 25.1 1.159 9 4.4 80 6.4 0 2 801.48718 -2.87 51.03 1601.96709

EQTMSECEAGALR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 8 1 45580688 N-Term(iTRAQ4plex); M4(Oxidation); C7(Methylthio)

0.633 4 12.3 0.773 4 6.4 0.536 4 20.6 0.645 4 6.6 0.612 4 15.3 0.737 4 6.3 1.119 4 5 65 5.26 0 3 792.84949 0.85 17.95 1584.67948

EQTMSECEAGALR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 13 1 45580688 N-Term(iTRAQ4plex); C7(Methylthio)

0.838 6 12.6 1.173 6 10.5 0.855 6 19.9 0.776 6 7.9 0.938 6 18.5 0.863 6 5.5 1.127 6 4.7 64 4.82 0 2 917.46405 -0.74 21.97 1833.91789

EQVAEVR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 2 1 4557325 N-Term(iTRAQ4plex) 0.752 13 13.6 0.979 13 10.7 0.735 13 17.3 0.733 13 12.6 0.77 13 24.9 0.782 13 9.7 1.116 13 5 63 4.27 0 2 696.862 -6.53 36.63 1392.71672

EQVQSCGPPPELLNGNVK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 9 1 62739186 N-Term(iTRAQ4plex); C6(Methylthio); K18(iTRAQ4plex)

1.142 1 0.723 1 0.995 1 1.376 1 0.973 1 1.346 1 0.978 1 40 0 2 793.39996 3.23 78.56 1585.79265

EQWILTAR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 6 1 205277383 N-Term(iTRAQ4plex) 0.699 6 7.7 1.107 6 18.2 0.695 6 20 0.66 6 5.8 0.8 6 10.7 0.723 6 5.4 1.105 6 6.2 38 0 2 542.80548 7.89 19.68 1084.59807

ERGPEEEHLGILGPVIWAEVGDTIR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 87 1 4557485 N-Term(iTRAQ4plex) 1.218 1 0.853 1 1.058 1 1.242 1 1.197 1 1.404 1 1.131 1 85 5.35 0 2 845.94922 -3.14 53.12 1690.89116

ERGVGQADWTPDLGLRNMAPGAVCSPGESK

TNKS1BP1 182 kDa tankyrase-1-binding protein [Homo sapiens]

85456 NP_203754 1 1 110556636 N-Term(iTRAQ4plex); M18(Oxidation); C24(Methylthio); K30(iTRAQ4plex)

1.23 2 2.4 0.943 2 16 1.143 2 10.4 1.211 2 5.6 1.251 2 10 1.326 2 5.9 1.095 2 0.3 82 4.82 0 2 753.39685 0.07 16.49 1505.78642

ERPGVYTNVVEYVDWILEK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.858 2 24.1 0.964 2 16.1 0.881 2 7.6 0.914 2 23.9 0.804 2 25.4 0.834 2 42.7 0.912 2 17.5 71 4.93 1 3 593.33221 -0.71 14.43 1777.98209

ESASLMVDR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 11 2 14550407 N-Term(iTRAQ4plex) 1.282 1 1.058 1 1.225 1 1.158 1 1.413 1 1.335 1 1.153 1 66 4.56 0 2 707.32123 -0.81 22.42 1413.63518

ESASLMVDR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 11 2 14550407 N-Term(iTRAQ4plex); M6(Oxidation)

1.24 4 2.9 0.91 4 20.5 1.126 4 12.4 1.154 4 12.7 1.23 4 14.9 1.334 4 3.7 1.143 4 7.3 66 6.15 0 3 1105.0686 2.58 74.24 2209.12516

ESCGYDTCYDWEK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 24 1 169636415 N-Term(iTRAQ4plex); C3(Methylthio); C8(Methylthio); K13(iTRAQ4plex)

1.148 1 0.8 1 0.941 1 1.177 1 1.125 1 1.407 1 1.195 1 62 3.96 0 2 803.36652 -6.02 36.46 1605.72576

ESDEETQIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 27 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.194 2 8.9 0.848 2 28.5 1.049 2 3.3 1.236 2 25.1 1.168 2 4.5 1.377 2 23.8 1.114 2 1.2 60 7.27 0 3 634.35406 -0.39 36.89 1901.04764

ESEQGVYTCTAQGIWK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

26 1 66347875 N-Term(iTRAQ4plex); C9(Methylthio); K16(iTRAQ4plex)

1.498 1 1.029 1 1.408 1 1.367 1 1.633 1 1.586 1 1.16 1 54 4.1 0 2 745.927 -1.61 38.06 1490.84673

ESHVTLASPEETR VASN vasorin precursor [Homo sapiens] 114990 NP_612449 2 1 88702793 N-Term(iTRAQ4plex) 0.923 1 1.102 1 0.971 1 0.882 1 0.969 1 0.88 1 0.998 1 51 0 2 753.39685 0.07 16.49 1521.78203ESILFHYTDWVDDQRPENYR

BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 8 1 4557351 N-Term(iTRAQ4plex) 1.586 3 10.9 0.995 3 52.9 1.699 3 4.8 1.708 3 47.3 1.465 3 28.6 1.472 3 21.9 0.862 3 17.9 46 6.91 0 4 1038.0391 0.93 69.25 4149.13442

ESKPLTAQQTTK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex); K3(iTRAQ4plex); K12(iTRAQ4plex)

1.214 2 1.7 0.919 2 10.7 1.083 2 8.2 1.179 2 2.4 1.249 2 5.5 1.359 2 5.2 1.153 2 2.7 45 4.1 0 2 691.36694 -0.03 31.78 1381.7249

ESLLNHFLYEVAR AFM afamin precursor [Homo sapiens] 173 NP_001124 81 1 4501987 N-Term(iTRAQ4plex) 1.36 2 0.7 1.002 2 0.6 1.262 2 5.3 1.259 2 4.7 1.461 2 2.7 1.458 2 3.3 1.158 2 8 44 4.94 0 3 693.35834 -3.86 47.81 2078.06046ESLSSYWESAK APOC2 apolipoprotein C-II precursor [Homo

sapiens]344 NP_000474 14 1 32130518 N-Term(iTRAQ4plex);

K11(iTRAQ4plex)1.135 2 2.4 0.949 2 15.4 1.042 2 9.6 1.098 2 5.8 1.174 2 10.1 1.237 2 5.3 1.127 2 0.5 42 3.46 0 2 614.79126 0.28 15.04 1228.57524

ESMLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.208 1 0.871 1 1.059 1 1.216 1 1.201 1 1.379 1 1.134 1 38 3.27 0 2 804.41718 -1.74 49.68 1607.82707

ESNEELTESCETK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

17 3 4504893;156231037

N-Term(iTRAQ4plex); C10(Methylthio); K13(iTRAQ4plex)

1.397 1 0.975 1 1.357 1 1.392 1 1.403 1 1.439 1 1.033 1 6.02 1 5 671.37415 1.51 45.77 3352.84162

ESPGNVQIVNGYFVHFFAPQGLPVVPK

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 46 1 133925809 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

1.127 1 0.909 1 0.999 1 1.099 1 1.153 1 1.268 1 1.153 1 3.03 0 2 544.32318 0.92 50.25 1087.63909

ESQLPTVMDFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex) 1.259 1 1.004 1 1.141 1 1.136 1 1.382 1 1.376 1 1.211 1 2.84 2 2 1075.0579 -5.85 45.91 2149.10845

ESQLPTVMDFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); M8(Oxidation)

1.212 2 4 1.01 2 18.1 1.165 2 13.5 1.154 2 4.6 1.275 2 12.7 1.263 2 5.4 1.095 2 0.8 39 6.37 0 3 691.37665 -5 37.81 2072.12015

ESTLHLVLR UBB polyubiquitin-B precursor [Homo sapiens]

7314 NP_061828 3 4 11024714 N-Term(iTRAQ4plex) 1.269 2 1.6 0.95 2 3.9 1.167 2 1.9 1.229 2 5.9 1.306 2 8.3 1.375 2 4.4 1.118 2 10.2 2.99 0 2 1075.552 -5.07 40.2 2150.09673

ESTVFEDLSDEAERDEYELLCPDNTR

LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 5 2 312433998 N-Term(iTRAQ4plex); C21(Methylthio)

1.166 3 20.3 0.967 3 0.2 1.071 3 37.9 0.94 3 12.5 1.222 3 39.8 1.222 3 5.1 1.141 3 1.8 82 4.79 0 2 932.43604 -3.19 18.57 1863.86479

ESVPISDTIIPAVPPPTDLR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

6 4 47132549;16933542

N-Term(iTRAQ4plex) 1.263 2 18.8 0.984 2 29.8 1.143 2 38.2 1.161 2 7.7 1.374 2 30.6 1.397 2 0.8 1.203 2 7 57 4.01 0 2 901.44763 2.34 44.52 1801.88799

ESYSGVTLDPR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 10 2 38016947 N-Term(iTRAQ4plex) 1.095 2 10.3 0.865 2 8.5 0.974 2 9.5 1.127 2 0.9 1.068 2 18.8 1.235 2 10.2 1.096 2 9.2 49 4.53 0 3 497.25089 -2.12 32.52 1489.737

ESYYFDLTDGLS KNG1 kininogen-1 isoform 2 precursor [Homo sapiens]

3827 NP_000884 1 1 156231037 N-Term(iTRAQ4plex) 1.086 1 0.927 1 0.981 1 1.058 1 1.112 1 1.199 1 1.134 1 45 0 2 584.77295 0.08 18.41 1168.53862

ETAASLLQAGYK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 33 1 4503635 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.067 1 0.944 1 0.965 1 1.022 1 1.109 1 1.175 1 1.149 1 25 3.24 0 2 724.81769 -1.79 46.33 1448.6281

ETAQAMAQLSR EXT2 exostosin-2 isoform 2 [Homo sapiens]

2132 NP_997005 1 3 46370069 N-Term(iTRAQ4plex); M6(Oxidation)

1.205 1 0.924 1 1.132 1 1.225 1 1.185 1 1.283 1 1.047 1 5.13 0 3 778.74805 -1.56 40.37 2334.22959

ETAVDGELVVLYDVK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 227 1 70778918 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.037 1 0.898 1 0.976 1 1.087 1 0.992 1 1.105 1 1.016 1 3.14 0 2 621.841 -0.37 55.37 1242.67473

ETEYGPCR IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 2 2 62243068 N-Term(iTRAQ4plex); C7(Methylthio)

1.143 1 0.85 1 1.002 1 1.18 1 1.112 1 1.308 1 1.109 1 66 7.01 0 3 676.35535 -1.01 56.04 2027.05149

ETFDVTLEPLSFK F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 6 1 119395709 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.312 1 1.008 1 1.178 1 1.168 1 1.457 1 1.446 1 1.238 1 56 8.32 0 3 671.01349 1.83 48.05 2011.02591

ETFLDPFVLR PTPRG receptor-type tyrosine-protein phosphatase gamma [Homo sapiens]

5793 NP_002832 2 1 194097398 N-Term(iTRAQ4plex) 1.177 1 0.986 1 1.107 1 1.122 1 1.231 1 1.248 1 1.112 1 34 5.75 0 3 843.13855 2.7 59.86 2527.4011

ETIEQEK TMSB4X thymosin beta-4 [Homo sapiens] 7114 NP_066932 4 2 11056061 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.19 2 13.8 0.808 2 30.7 1.015 2 27.1 1.256 2 3.4 1.148 2 28.2 1.421 2 2.4 1.132 2 1 40 0 2 518.85431 0.44 28.74 1036.69475

ETLEDTR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex) 1.236 1 0.787 1 1.017 1 1.293 1 1.191 1 1.514 1 1.171 1 27 0 2 436.79675 6.25 17.81 872.58623

ETLENPK CDH13 cadherin-13 isoform 3 precursor [Homo sapiens]

1012 NP_001207418 1 4 333944018 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.634 1 0.913 1 1.46 1 1.599 1 1.666 1 1.825 1 1.142 1 3.75 1 3 958.15833 -6.91 20.73 2872.46042

ETLFSVMPGLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

99 2 31542984;262050538

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.336 1 1.179 1 2.476 1 2.1 1 2.615 1 2.218 1 1.056 1 32 0 2 448.26166 -0.11 14.08 895.51604

ETLFSVMPGLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

21 2 31542984;262050538

N-Term(iTRAQ4plex); M7(Oxidation); K11(iTRAQ4plex)

1.678 6 15.5 0.784 6 8 1.381 6 24.2 1.564 6 12.1 1.801 6 20.1 2.056 6 15.4 1.266 6 8.8 82 6.63 0 4 1122.6377 0.54 67.21 3365.902

ETLLQDFR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 17 1 4502067 N-Term(iTRAQ4plex) 1.743 5 17.8 0.874 5 14.4 1.439 5 11.7 1.676 5 14.2 1.981 5 13.7 1.802 5 6.7 1.157 5 13.6 80 5.01 0 3 950.4892 0.59 61.67 1899.96842

ETMVTSTTEPSR PRKCSH glucosidase 2 subunit beta isoform 2 precursor [Homo sapiens]

5589 NP_001001329 2 2 48255891 N-Term(iTRAQ4plex) 2.416 3 3.8 1.004 3 14.8 2.497 3 8.1 2.251 3 8.4 2.206 3 31.3 2.35 3 6.8 1.093 3 1.5 79 5.39 1 3 582.97479 -0.29 16.74 1746.91367

ETQSIEK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 6 4 189181722 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.987 4 2.7 0.921 4 12.5 1.813 4 3.4 1.848 4 4.2 2.074 4 3.8 2.223 4 4.6 1.149 4 2.5 73 4.2 0 2 705.89966 -11.52 37.89 1410.79204

ETSLTVNK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 2 4 189181722 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.759 3 11.8 1.003 3 12.5 1.382 3 18.7 1.837 3 2.5 1.679 3 24.3 1.968 3 21.4 1.118 3 6.4 72 4.74 0 3 582.9964 1.05 49.87 1746.97464

ETSNFGFSLLR SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 3 1 7705879 N-Term(iTRAQ4plex) 1.364 3 8.1 1.109 3 17.8 1.405 3 9.7 1.187 3 8 1.56 3 5.9 1.406 3 23.8 1.067 3 8.1 69 4.16 0 2 696.41785 -4.61 30.02 1391.82842

ETTFNSLLCPSGGEVSEELSLK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 10 1 66932947 N-Term(iTRAQ4plex); C9(Methylthio); K22(iTRAQ4plex)

1.93 3 3.5 0.985 3 3.3 1.548 3 7.5 1.896 3 15.9 1.805 3 17.4 2.086 3 32.7 1.1 3 8.7 66 5.24 0 3 960.56018 -3.48 60.56 1920.11679

ETTIQGLDGLSER ALDOB fructose-bisphosphate aldolase B [Homo sapiens]

229 NP_000026 4 1 40354205 N-Term(iTRAQ4plex) 1.878 2 8 1.04 2 2.6 1.819 2 8.3 1.748 2 5.7 2.014 2 10.1 1.936 2 7.5 1.107 2 1.8 66 3.05 0 2 618.85889 -0.59 25.63 1236.71196

ETTVETK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 2 4 189181722 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.681 1 0.931 1 1.592 1 1.709 1 1.654 1 1.777 1 1.039 1 65 3.8 0 2 864.49377 -0.59 59.93 1727.98027

ETVLTFIDPEGSEVDMVEEIDHIGIISFPDFK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 25 2 38016947 N-Term(iTRAQ4plex); M16(Oxidation); K32(iTRAQ4plex)

1.522 1 1.04 1 1.486 1 1.429 1 1.617 1 1.556 1 1.089 1 56 4 0 2 703.8548 -4.36 25.65 1406.70232

ETVLTFIDPEGSEVDMVEEIDHIGIISFPDFK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 13 2 38016947 N-Term(iTRAQ4plex); K32(iTRAQ4plex)

2.242 2 8.5 0.968 2 8 2.069 2 12.6 2.138 2 4.6 2.345 2 12.2 2.423 2 4.2 1.133 2 0.3 56 4.88 0 2 757.87781 -6.77 38.74 1514.74834

ETVQTTEDQILK VCL vinculin isoform VCL [Homo sapiens]

7414 NP_003364 2 2 4507877 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.316 1 0.891 1 2.131 1 2.392 1 2.249 1 2.525 1 1.055 1 55 8.16 0 3 786.08215 1.48 55.45 2356.23191

ETWTANVGK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 9 1 4503635 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.758 1 0.944 1 1.799 1 1.905 1 1.619 1 1.714 1 0.9 1 54 3.87 0 3 752.40314 3.36 72.11 2255.19486

ETYDFDIAVLR F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 4 1 4503625 N-Term(iTRAQ4plex) 2.253 1 0.924 1 1.991 1 2.155 1 2.344 1 2.537 1 1.177 1 45 3.07 0 2 588.32861 -0.14 26.1 1175.64995

EVAFDLEIPK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 108 1 156119625 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.494 3 6.9 1.012 3 24.6 1.53 3 1.9 1.513 3 2.2 1.648 3 22.6 1.549 3 7.5 1.077 3 9.7 44 0 3 518.98785 -0.52 76.51 1554.94901

EVASNSELVQSSR KRT16 keratin, type I cytoskeletal 16 [Homo sapiens]

3868 NP_005548 5 1 24430192 N-Term(iTRAQ4plex) 1.919 1 0.999 1 1.865 1 1.866 1 1.971 1 1.972 1 1.057 1 41 4.34 0 2 692.88916 0.36 41.88 1384.77104

EVCSEQAETGPCR APP amyloid beta A4 protein isoform f precursor [Homo sapiens]

351 NP_001129602 2 6 209915573 N-Term(iTRAQ4plex); C3(Methylthio); C12(Methylthio)

1.942 1 0.864 1 1.683 1 1.948 1 1.938 1 2.242 1 1.151 1 40 4.74 0 2 739.36682 0.83 16.29 1477.72637

EVDSGNDIYGNPIK TIMP2 metalloproteinase inhibitor 2 precursor [Homo sapiens]

7077 NP_003246 XP_946197

4 1 4507511 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.572 2 30.4 0.938 2 2.4 1.47 2 27.4 1.567 2 30 1.577 2 30.8 1.681 2 33.4 1.073 2 3.2 39 3.28 0 2 631.38055 2.48 25.07 1261.75383

EVEEDEYK HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 2 1 4507677 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.999 2 4.1 0.756 2 12.5 1.626 2 8.7 2.151 2 3.8 1.886 2 10.1 2.495 2 2.4 1.16 2 1.4 33 3.86 0 3 487.93683 1.93 18.49 1461.79007

EVEGQILGTYVCIK C4BPB C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

725 NP_001017364 6 2 62912462 N-Term(iTRAQ4plex); C12(Methylthio); K14(iTRAQ4plex)

1.111 1 0.949 1 2.166 1 2.282 1 8.18 0 4 840.68384 0.73 41.47 3359.71352

EVELIVQEKPFTVEISPGPR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 2 4507875 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

3.066 1 0.415 1 2.385 1 5.744 1 1.955 1 4.708 1 0.82 1 6.54 0 4 1122.6377 0.54 67.21 3381.90078

EVFSRYGPLSGVNVVYDQRTGR

TRA2A transformer-2 protein homolog alpha [Homo sapiens]

29896 NP_037425 1 1 9558733 N-Term(iTRAQ4plex) 2.052 1 0.973 1 1.844 1 1.894 1 2.205 1 2.265 1 1.196 1 4.21 1 3 732.7467 -0.97 32.57 2196.22556

EVGPPLPQEAVPLQK ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 8 3 221316614 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.035 1 0.899 1 0.915 1 1.018 1 1.051 1 1.17 1 1.149 1 4.69 0 3 677.37927 3.51 25.87 2030.12326

EVGPTNADPVCLAK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 85 1 4557485 N-Term(iTRAQ4plex); C11(Methylthio); K14(iTRAQ4plex)

1.314 1 1.039 1 1.31 1 1.261 1 1.37 1 1.318 1 1.045 1 51 4.94 0 3 482.94159 -5.79 26.7 1446.81021

EVGTPHGIILDSVDAAFICPGSSR

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 1103 1 11321561 N-Term(iTRAQ4plex); C19(Methylthio)

1.241 1 0.859 1 1.134 1 1.321 1 1.172 1 1.365 1 1.033 1 36 4.3 0 3 980.46973 2.59 59.27 2939.39463

EVGTVLSQVYSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 19 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.642 1 0.906 1 0.562 1 0.621 1 0.661 1 0.73 1 1.176 1 2.96 0 2 585.3548 1.05 42.18 1169.70232

EVLLLVHNLPQQLFGYSWYK

CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor [Homo sapiens]

634 NP_001171745 1 6 296317314 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

0.855 2 2.3 0.97 2 5.8 0.783 2 0.3 0.807 2 6.1 0.902 2 1.3 0.93 2 4.4 1.153 2 1.7 59 4.84 0 2 837.86481 -0.35 41.51 1674.72234

EVLYELIEK TAZ tafazzin isoform 4 [Homo sapiens] 6901 NP_851830 1 4 31317263 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.445 1 1.081 1 1.427 1 1.32 1 1.58 1 1.461 1 1.107 1 36 4.27 1 3 610.95007 6.35 32.12 1830.83567

EVPCASVK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 4 1 45580688 N-Term(iTRAQ4plex); C4(Methylthio); K8(iTRAQ4plex)

2.65 8 34 0.998 7 23.7 2.388 8 18.2 2.366 7 28.1 2.201 8 41.9 2.972 7 28.4 1.082 8 22.6 105 6.61 0 3 1309.5955 2.43 58.63 2618.17728

EVPLLQSLWLAHNEIR ISLR immunoglobulin superfamily containing leucine-rich repeat protein precursor [Homo sapiens]

3671 NP_005536 4 1 5031809 N-Term(iTRAQ4plex) 2.768 31 14.9 0.903 31 17.4 2.434 31 17.9 2.646 31 15.8 2.855 31 17.4 3.072 31 14 1.153 31 8.7 103 7.55 0 3 1091.611 1.63 59.73 2182.21465

EVPLSALTNILSAQLISHWK SERPINE1 plasminogen activator inhibitor 1 isoform 2 precursor [Homo sapiens]

5054 NP_001158885 6 2 259155306 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

2.623 17 25.6 0.933 17 13.1 2.501 17 49.7 2.511 17 19.5 2.793 17 30.2 2.767 17 18.1 1.118 17 3.5 100 7.42 0 2 1091.1011 2.96 46.63 2181.19487

EVQPVELPNCNLVK PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 4 1 19923106 N-Term(iTRAQ4plex); C10(Methylthio); K14(iTRAQ4plex)

2.06 26 17.8 0.975 26 22.3 2.086 26 18.7 1.923 26 26.2 2.228 26 16.8 2.173 26 23.8 1.121 26 16.3 87 6.89 0 3 876.84644 1.21 67.39 2628.52915

EVSFDVELPK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 26 1 133925809 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.54 2 17 0.706 2 15.7 1.984 2 29.3 2.811 2 13.1 2.352 2 19.1 3.332 2 3.3 1.185 2 9.8 76 4.29 0 2 594.87744 -6.61 17.16 1188.74761

EVTVPVFYPTEK MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 4 1 71274107 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.901 4 8 0.98 4 11.4 2.526 4 24.3 2.857 4 9.6 2.859 4 20.4 3.153 4 13.3 1.132 4 3 69 3.5 0 2 554.78564 -8.42 14.74 1108.56401

EVTVQGLEPSR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 1 188528648 N-Term(iTRAQ4plex) 3.286 1 0.887 1 2.864 1 3.228 1 3.337 1 3.761 1 1.165 1 64 6.82 1 3 614.39038 -2.7 46.24 1841.15659

EVVADSVWVDVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 55 1 115298678 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.49 11 22.9 0.986 11 12.2 2.215 11 34.2 2.564 11 23.1 2.503 11 30.6 2.809 11 10.6 1.105 11 3.1 55 3.42 0 2 662.38989 -2.13 40.43 1323.77422

EVVSLTEACCAEGADPDCYDTR

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 153 2 32483410 N-Term(iTRAQ4plex); C9(Methylthio); C10(Methylthio); C18(Methylthio)

1.811 3 73.9 0.891 3 15.1 1.544 3 29.2 1.917 3 105.2 1.727 3 48.3 2.144 3 117 1.119 3 2.2 53 3.13 0 2 628.86304 -4.26 24.56 1256.7188

EVVTDQFLCSGTQEDESPCK

C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 24 3 14550407 N-Term(iTRAQ4plex); C9(Methylthio); C19(Methylthio); K20(iTRAQ4plex)

2.261 7 24 0.957 7 11.3 2.022 7 23.5 2.169 7 21.4 2.348 7 25.6 2.518 7 30.2 1.098 7 3.9 50 4.26 0 3 378.55936 7.68 35.81 1133.66399

EVVTDQFLCSGTQEDESPCKGESGGAVFLER

C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 8 3 14550407 N-Term(iTRAQ4plex); C9(Methylthio); C19(Methylthio); K20(iTRAQ4plex)

2.857 3 10.1 0.891 3 20 2.584 3 15.8 2.823 3 4.1 2.818 3 23.7 3.164 3 3.5 1.091 3 7.6 48 4.1 0 2 648.86151 1.26 17.95 1296.71575

EVVTSEDGSDCPEAMDLGTLSGIGTLDGFR

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 10 2 4503689 N-Term(iTRAQ4plex); C11(Methylthio)

4.959 4 7.7 23.769 3 10.2 54.16 3 3.3 2.496 3 13.6 52.52 3 29.5 2.684 3 18.8 1.108 4 5.3 43 6.54 0 4 1035.2379 -0.96 48.31 3103.70009

EVVTSEDGSDCPEAMDLGTLSGIGTLDGFR

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex); C11(Methylthio); M15(Oxidation)

2.795 2 19.4 0.915 2 9.3 2.54 2 14.1 2.775 2 23.6 2.817 2 15.6 3.078 2 25.1 1.109 2 1.4 39 3.83 0 3 549.82819 -1.72 13.25 1098.65192

EVYGFNPEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.982 2 5.4 0.832 2 5.9 1.733 2 10.9 2.084 2 5 1.898 2 5.6 2.282 2 0.3 1.095 2 5.3 33 0 2 478.78607 0.3 30.27 956.56487

EVYIK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 2 1 67782358 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.152 1 0.971 1 1.067 1 1.099 1 1.203 1 1.238 1 1.127 1 105 5.61 0 2 983.50519 -4.55 23.17 1966.0031

EVYMPSSIFQDDFVIPDISEPGTWK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

100 6 178557739;67190748

N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.225 2 3.4 0.969 2 1.5 1.071 2 5.1 1.105 2 6.6 1.337 2 11.7 1.381 2 10.1 1.249 2 16.9 97 6.31 0 2 913.00458 -0.08 58.65 1825.00188

Page 13: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

EVYMPSSIFQDDFVIPDISEPGTWK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

15 6 178557739;67190748

N-Term(iTRAQ4plex); M4(Oxidation); K25(iTRAQ4plex)

1.175 2 7.4 0.898 2 20.8 1.046 2 4.2 1.165 2 16.5 1.189 2 0.6 1.323 2 20.1 1.136 2 3.5 94 4.52 0 2 859.95239 1.33 19.64 1718.89751

EWDLLLFLLRELVEK CDAN1 codanin-1 [Homo sapiens] 146059 NP_612486 XP_944061

2 1 57222570 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.118 2 3.7 0.998 2 9.1 1.072 2 0.6 1.074 2 9.6 1.163 2 2.1 1.166 2 7 1.086 2 2.6 87 7.14 0 3 1132.0618 1.8 37.87 2263.11728

EWEIVNQDNHYSPHFQEIR DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex) 1.036 4 9.7 0.913 4 16 0.924 4 17.1 1.105 4 5.8 1.068 4 14.3 1.237 4 5.9 1.11 4 4.8 87 4.52 0 2 855.94208 -2.98 26.02 1710.87688

EWFSETFQK APOC1 apolipoprotein C-I precursor [Homo sapiens]

341 NP_001636 12 1 4502157 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.097 1 0.99 1 1.025 1 1.036 1 1.157 1 1.168 1 1.128 1 87 4.49 0 2 802.92273 -1.77 32.73 1604.83818

EWFWDLATGTMK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 180 1 11321561 N-Term(iTRAQ4plex); M11(Oxidation); K12(iTRAQ4plex)

1.217 2 3.4 0.96 2 4 1.134 2 12 1.181 2 8 1.249 2 0.6 1.301 2 4.6 1.101 2 12.6 86 5.84 0 3 1019.0848 -4.04 18.74 2037.16147

EWFWDLATGTMK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 668 1 11321561 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.344 2 11.8 1.001 2 18 1.36 2 11.6 1.358 2 30.1 1.33 2 6.2 1.328 2 11.7 0.978 2 17.9 84 5.54 0 2 1063.0703 -2.18 43.12 2125.13335

EWVAIESDSVQPVPR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 4 1 21071039 N-Term(iTRAQ4plex) 1.227 1 0.951 1 1.166 1 1.226 1 1.228 1 1.291 1 1.053 1 74 4.73 1 2 939.03668 4.16 22.59 1877.06609

EYANQFMWEYSTNYGQAPLSLLVSYTK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 14 2 32483410 N-Term(iTRAQ4plex); M7(Oxidation); K27(iTRAQ4plex)

1.114 2 4 0.997 2 15.8 1.019 2 12.3 1.022 2 3.4 1.209 2 11.5 1.212 2 4.3 1.187 2 0.8 65 4.56 0 2 843.5 -0.06 53.42 1685.99272

EYANQFMWEYSTNYGQAPLSLLVSYTK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 103 2 32483410 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

1.034 1 0.963 1 0.96 1 0.997 1 1.07 1 1.111 1 1.115 1 55 3.08 0 2 609.83398 3.92 24.71 1218.66069

EYAPGETVK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.073 2 18.4 0.944 2 2.6 1.024 2 9.7 1.085 2 7.1 1.056 2 29.7 1.119 2 27 1.032 2 19.6 48 5.14 0 3 678.02991 0.92 28.54 2032.07517

EYCGVPGDGDEELLR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 57 1 4502067 N-Term(iTRAQ4plex); C3(Methylthio)

1.049 1 1.036 1 1.001 1 0.965 1 1.136 1 1.097 1 1.136 1 46 4.17 0 2 729.36359 -1.16 44.06 1457.7199

EYELESLFEHYCYSR PEPD xaa-Pro dipeptidase isoform 1 [Homo sapiens]

5184 NP_000276 NP_116041

4 2 149589008 N-Term(iTRAQ4plex); C12(Methylthio)

1.113 1 1.013 1 1.021 1 1.007 1 1.221 1 1.205 1 1.196 1 33 5.61 1 3 600.99048 0.64 37.95 1800.95688

EYEPYFK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.029 1 1.094 1 1.045 1 0.956 1 1.11 1 1.015 1 1.062 1 31 0 2 565.81238 0.06 31.63 1130.61748

EYESYSDFER C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 10 1 4557391 N-Term(iTRAQ4plex) 1.456 1 1.066 1 1.443 1 1.354 1 1.564 1 1.467 1 1.084 1 4.5 0 3 693.37842 2.65 41.35 2078.1207

EYFAIDNSGR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 2 1 166362713 N-Term(iTRAQ4plex) 1.361 15 17.7 0.995 15 19.7 1.365 15 13.8 1.331 15 29.8 1.405 15 22.2 1.467 15 24.2 1.096 15 15.3 114 8.53 0 3 1258.1218 0.8 80.82 2515.23638

EYGVVLAPDGSTVAVEPLLAGLEAGLQGR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 33 1 156616294 N-Term(iTRAQ4plex) 1.536 12 7.9 1.004 12 8.9 1.418 12 15.6 1.525 12 13.7 1.655 12 12.8 1.7 12 6.9 1.152 12 7.3 108 6.59 0 3 882.96539 -0.8 47.6 1764.92351

EYHFGQAVR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 8 2 62739186 N-Term(iTRAQ4plex) 1.431 38 6 0.95 38 8.6 1.315 38 8.4 1.388 38 8 1.517 38 7.5 1.582 38 7.3 1.16 38 3.9 106 8.54 0 3 1094.9983 -0.91 52.61 2188.99234

EYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSER

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

99 6 178557739;67190748

N-Term(iTRAQ4plex) 1.627 32 14.5 0.906 32 12.3 1.51 32 19 1.633 32 21.5 1.555 32 18.8 1.724 32 12.8 1.067 32 12.2 96 6.72 0 3 1127.0919 -1.28 33.87 2253.18656

EYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSER

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

55 6 178557739;67190748

N-Term(iTRAQ4plex); M31(Oxidation)

1.547 14 16.7 0.954 14 11.7 1.376 14 17.5 1.415 14 20.6 1.571 14 16 1.724 14 16.8 1.118 14 9.4 87 6.58 0 2 1152.1002 -0.16 27.22 2303.19097

EYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSER

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

4 6 178557739;67190748

N-Term(iTRAQ4plex); M5(Oxidation); M31(Oxidation)

1.505 7 6.3 1.02 7 7.7 1.467 7 18.4 1.41 7 6.9 1.647 7 6.6 1.553 7 5.2 1.123 7 4 73 4.72 1 3 517.95129 0.95 28.01 1551.84262

EYSGTIASEANTYLNSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 24 1 105990532 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.729 4 16.9 0.989 4 10.5 1.667 4 16.8 1.659 4 8.7 1.801 4 20.4 1.892 4 8.1 1.139 4 7.9 64 5.65 0 3 1152.1002 -0.16 27.22 2319.17722

EYTDASFTNR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 37 1 4557485 N-Term(iTRAQ4plex) 1.546 7 11.4 0.953 7 11.4 1.296 7 23.6 1.518 7 14 1.512 7 30.5 1.713 7 11.5 1.151 7 2 57 4.06 0 2 661.8645 2.42 33.89 1322.71953

EYTNIFLK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 14 1 4503649 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.664 2 5.3 1.102 2 5.3 1.657 2 5.3 1.503 2 0.1 1.841 2 10.5 1.671 2 5.3 1.111 2 5.2 49 3.12 0 2 495.81201 -1.9 13.77 990.62059

EYVLPHFSVSIEPEYNFIGYK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 32 2 38016947 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.542 2 6.2 0.936 2 9.3 1.415 2 11.4 1.511 2 2.1 1.573 2 10.2 1.68 2 0.9 1.112 2 1.2 45 4.02 0 3 386.87683 1.97 13.6 1158.61594

EYVLPSFEVIVEPTEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 30 1 115298678 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.57 3 1.2 0.92 3 2.9 1.53 3 2.6 1.663 3 19.5 1.657 3 16.5 1.613 3 0.3 0.97 3 2.6 39 5.55 0 3 528.32257 0.77 16.3 1582.95316

EYYFAEAQIADFSDPAFISK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 135 1 73858566 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.597 2 1.6 0.952 2 4.8 1.506 2 2.7 1.581 2 2 1.613 2 1.1 1.693 2 5.9 1.071 2 3.9 37 3.87 0 2 640.32208 -3.07 38.03 1279.63848

FACYYPR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

3 6 178557739;67190748

N-Term(iTRAQ4plex); C3(Methylthio)

1.497 10 7 1.058 10 16.2 1.462 10 21.8 1.47 10 15.1 1.614 10 13.8 1.63 10 12.9 1.155 10 5.3 86 5.2 0 2 1108.5571 -0.19 43.39 2216.10698

FAFNLYR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 17 1 73858566 N-Term(iTRAQ4plex) 1.702 2 15.1 0.81 2 10.7 1.369 2 25.3 1.69 2 14.4 1.712 2 15.7 2.115 2 5 1.251 2 9.4 49 4.67 0 2 701.40033 0.21 18.51 1401.79338

FAGVFHVEK CD44 CD44 antigen isoform 8 precursor [Homo sapiens]

960 NP_001189486 3 8 321400142 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.86 4 8.2 0.954 4 3.6 1.707 4 7.2 1.772 4 5.2 1.948 4 10.8 1.98 4 9.6 1.126 4 3.4 43 4.19 0 2 614.84363 -0.57 43.45 1228.68059

FAHNVVTMR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 1 1 133925809 N-Term(iTRAQ4plex) 1.61 2 2.4 0.873 2 5.6 1.409 2 7.5 1.615 2 1.9 1.605 2 2.9 1.84 2 2.7 1.139 2 4.5 5.04 0 3 534.96472 -2.3 15.66 1602.87961

FAHTVVTSR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

5 2 31542984;262050538

N-Term(iTRAQ4plex) 1.065 3 16.2 0.979 3 13.9 1.011 3 22.3 1.091 3 6.5 1.098 3 34.1 1.278 3 13.6 1.171 3 7 72 4.36 0 2 697.37396 -0.49 12.56 1393.74065

FAHYVVTSQVVNTANEAR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 96 1 156119625 N-Term(iTRAQ4plex) 0.864 2 1.2 0.904 2 3.1 0.79 2 3.5 0.874 2 0.5 0.856 2 1.9 0.947 2 1.2 1.084 2 1.6 70 5.98 0 3 956.51263 -2.73 34.88 1912.02628

FAIQTDPNSNDGLVTVVKPIDFETNR

CDH2 cadherin-2 preproprotein [Homo sapiens]

1000 NP_001783 2 1 14589889 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.595 1 0.873 1 1.337 1 1.531 1 1.651 1 1.891 1 1.235 1 63 6.39 0 3 658.04626 5.17 25.97 1972.12424

FASFIDK KRT72;KRT5;KRT6A;KRT

2

keratin, type II cytoskeletal 72 isoform 2 [Homo sapiens];keratin, type II cytoskeletal 5 [Homo sapiens];keratin, type II cytoskeletal 6A [Homo sapiens];keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

140807;3852;3853;38

49

NP_001139698;NP_000415;NP_005545 NP_490596;NP_000414

6 22 226246665;119395754;5031839;47132620

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.968 2 29.6 1.358 2 56.3 1.135 2 8.5 0.835 2 46.2 1.18 2 5.8 0.869 2 63.6 1.04 2 14.4 60 4.46 0 2 940.47943 10.39 20.77 1879.95159

FCDMPVFENSR CFHR4 complement factor H-related protein 4 isoform 3 precursor [Homo sapiens]

10877 NP_006675 2 3 117320518 N-Term(iTRAQ4plex); C2(Methylthio)

1.232 1 1.009 1 1.169 1 1.159 1 1.305 1 1.294 1 1.117 1 59 4.62 0 2 783.39624 -4.88 26.3 1565.7852

FCEAEFSVK ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 6 2 221316614 N-Term(iTRAQ4plex); C2(Methylthio); K9(iTRAQ4plex)

1.001 1 0.974 1 0.904 1 0.928 1 1.071 1 1.1 1 1.185 1 57 3.81 0 2 658.32355 -0.09 32.25 1315.63982

FCEIGSDDCYVGDGYSYR HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 6 2 295054188 N-Term(iTRAQ4plex); C2(Methylthio); C9(Methylthio)

1.62 1 0.87 1 1.443 1 1.659 1 1.586 1 1.824 1 1.099 1 51 5.06 0 3 956.51263 -2.73 34.88 1928.0134

FCENPDEVK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); C2(Methylthio); K9(iTRAQ4plex)

0.995 2 2.6 1.013 2 3.8 0.9 2 4.8 0.888 2 1 1.103 2 4.2 1.089 2 0.4 1.226 2 0.6 49 3.7 0 2 685.85785 0.83 36.01 1370.70842

FCGQLGSPLGNPPGK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

26 1 66347875 N-Term(iTRAQ4plex); C2(Methylthio); K15(iTRAQ4plex)

1.068 2 0 0.938 2 7.1 0.966 2 4 1.03 2 3 1.105 2 2.9 1.178 2 4.2 1.143 2 1.2 38 3.53 0 2 561.81653 -1.6 20.76 1122.63078

FCGTFRPAPLVAPGNQVTLR

PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 1 1 157653329 N-Term(iTRAQ4plex); C2(Methylthio)

0.992 2 9 0.899 2 18.7 0.883 2 19.1 0.982 2 0.4 1.005 2 16.9 1.118 2 1.7 1.139 2 2.1 63 4.01 0 2 677.89325 -2.1 20.88 1354.77886

FCPDGSPSECHEHADCVLER

COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 4 1 40217843 N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio); C16(Methylthio)

0.752 1 1.007 1 0.725 1 0.72 1 0.784 1 0.778 1 1.081 1 63 5.31 0 2 929.49518 -2.15 38.2 1857.98308

FDGGVEAIATR MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 6 1 24497519 N-Term(iTRAQ4plex) 0.987 1 0.934 1 0.863 1 0.924 1 1.046 1 1.119 1 1.212 1 55 4.79 0 2 866.93817 -0.36 48.22 1732.86907

FDHTNSLNIAGLSLDFSSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 21 1 105990532 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.792 1 1.184 1 0.809 1 0.683 1 0.92 1 0.778 1 1.138 1 51 3.58 0 2 617.38409 -3.87 24.31 1233.76091

FDHVITNMNNNYEPR C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 12 1 87298828 N-Term(iTRAQ4plex) 0.867 1 1.332 1 1.252 1 0.939 1 0.771 1 0.579 1 0.616 1 42 7.29 0 4 882.93011 -0.9 80.61 3528.69863

FDHVITNMNNNYEPR C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 8 1 87298828 N-Term(iTRAQ4plex); M8(Oxidation)

1.361 1 0.958 1 1.229 1 1.283 1 1.436 1 1.498 1 1.168 1 31 0 2 494.83545 -0.91 28.86 988.66362

FDLELPDGNR ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 3 preproprotein [Homo sapiens]

11093 NP_620595 2 3 21265043 N-Term(iTRAQ4plex) 1.297 11 6.7 0.912 11 7.9 1.246 11 18.8 1.372 11 11.5 1.343 11 14.3 1.533 11 12.1 1.113 11 8.7 88 5.19 0 2 797.3949 -0.76 28.35 1593.78252

FDLEPDTYCR PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 2 1 157653329 N-Term(iTRAQ4plex); C9(Methylthio)

1.229 1 1.129 1 1.222 1 1.082 1 1.394 1 1.235 1 1.141 1 54 4.23 0 2 684.93616 -4 31.76 1368.86504

FDLNDVYVYWQTSESK ICOSLG ICOS ligand precursor [Homo sapiens]

23308 NP_056074 2 1 27477039 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.517 1 1.115 1 1.383 1 1.24 1 1.825 1 1.637 1 1.319 1 37 4.73 1 3 690.05359 -2.79 27.47 2068.14621

FDPSLTQR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 4 2 115583663 N-Term(iTRAQ4plex) 0.768 1 1.033 1 0.73 1 0.706 1 0.831 1 0.804 1 1.139 1 75 5.2 0 2 725.38458 -3.92 23.24 1449.76189

FDPTWESLDAR FUCA2 plasma alpha-L-fucosidase precursor [Homo sapiens]

2519 NP_114409 2 1 40068512 N-Term(iTRAQ4plex) 0.636 2 12.3 1.046 2 1.7 0.637 2 7.3 0.609 2 5.6 0.663 2 18.9 0.633 2 17.2 1.04 2 11.5 49 3.71 0 2 636.81885 0.23 22.27 1272.63042

FDPVR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 1 2 11321561 N-Term(iTRAQ4plex) 1.014 1 1.001 1 0.715 1 0.715 1 1.314 1 1.313 1 1.836 1 4.65 0 5 662.31628 6.82 48.32 3307.55231

FDPVRGEVPPR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 6 1 11321561 N-Term(iTRAQ4plex) 1.427 2 10.3 1.012 2 17.2 1.297 2 13.8 1.282 2 3.3 1.577 2 23.3 1.558 2 5.9 1.216 2 9.3 97 5.87 0 3 910.47711 2.73 44.43 1819.94474

FDVSSFNPHGISTFTDEDNAMYLLVVNHPDAK

PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 1 1 19923106 N-Term(iTRAQ4plex); K32(iTRAQ4plex)

1.404 5 6.5 1.05 5 23.2 1.345 5 20.1 1.287 5 12.5 1.607 5 15.2 1.453 5 7.8 1.125 5 4 76 9.25 0 4 972.49951 0.64 57.35 2915.48379

FEDCCQEK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 262 2 32483410 N-Term(iTRAQ4plex); C4(Methylthio); C5(Methylthio); K8(iTRAQ4plex)

1.257 1 0.756 1 1.067 1 1.412 1 1.14 1 1.508 1 1.068 1 76 3.42 0 2 831.92633 -2.16 39.41 1662.84538

FEDGVLDPDYPR VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 80 1 88853069 N-Term(iTRAQ4plex) 1.258 2 0.9 0.795 2 16.2 1.065 2 6 1.339 2 10.2 1.196 2 6.4 1.505 2 9.7 1.124 2 0.5 72 4.16 0 2 860.47809 -10.66 25.25 1719.9489

FEELNMDLFR HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 2 1 16507237 N-Term(iTRAQ4plex) 1.35 1 0.928 1 1.234 1 1.329 1 1.37 1 1.475 1 1.11 1 67 4.33 0 2 831.92633 -2.16 39.41 1646.85295

FEGIACEISK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 21 1 4502511 N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

1.23 2 5.5 0.987 2 13.2 1.168 2 4.2 1.183 2 9 1.279 2 1.9 1.295 2 15.1 1.095 2 6.1 65 5.23 1 3 980.02264 -1.23 24.89 1959.04135

FEIENCLANK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 4 1 162809334 N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

1.278 2 5.8 0.891 2 0.6 1.152 2 1.8 1.292 2 2.4 1.264 2 8.9 1.418 2 9.5 1.097 2 7.1 64 3.91 0 3 937.52893 -0.43 52.58 1874.05167

FEMEQNLR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 3 2 55956899 N-Term(iTRAQ4plex) 1.418 3 13.1 1.088 3 13.5 1.363 3 15.7 1.262 3 1 1.597 3 27.3 1.467 3 2.8 1.171 3 3.9 61 5.69 0 3 648.68298 1.86 59.38 1944.0344

FEQLELRPVLYNYLDK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

7 6 178557739;67190748

N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.249 2 0.6 0.986 2 8.6 1.146 2 5.2 1.163 2 3.3 1.334 2 4.5 1.354 2 4.1 1.165 2 0.7 58 4.67 0 2 716.36823 0.54 44.6 1431.72917

FEVNNTILHPEIVECR PEPD xaa-Pro dipeptidase isoform 1 [Homo sapiens]

5184 NP_000276 NP_116041

5 2 149589008 N-Term(iTRAQ4plex); C15(Methylthio)

1.234 4 6.1 0.928 4 15.4 1.038 4 2.8 1.192 4 5.9 1.266 4 12.1 1.364 4 14.4 1.158 4 2.8 58 4.58 0 2 775.45032 -2.46 81.11 1549.89336

FEVQVTVPK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 8 1 66932947 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.118 3 4.9 1.064 3 21.3 1.154 3 0.3 1.085 3 0.4 1.252 3 6.8 1.233 3 14.6 1.136 3 7.1 53 4.25 0 2 721.90594 0.79 39.6 1442.80461

FEVYGCK NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 1 5 66864913 N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

1.274 2 7.6 0.892 2 5.9 1.169 2 12.5 1.31 2 6.6 1.242 2 8.4 1.392 2 2.6 1.063 2 4 52 3.36 0 2 683.34027 -0.28 10.94 1365.6729

FEYPICE CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 1 1 13540563 N-Term(iTRAQ4plex); C6(Methylthio)

1.407 1 1.113 1 1.421 1 1.277 1 1.551 1 1.394 1 1.092 1 50 3.74 0 2 641.86847 3.98 23.17 1282.72966

FFACIK TIMP2 metalloproteinase inhibitor 2 precursor [Homo sapiens]

7077 NP_003246 XP_946197

1 1 4507511 N-Term(iTRAQ4plex); C4(Methylthio); K6(iTRAQ4plex)

1.614 1 0.826 1 1.251 1 1.514 1 1.697 1 2.053 1 1.356 1 45 5.68 0 3 817.07404 -2.07 57.56 2449.20755

FFETCDLDNDK SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 6 1 4507171 N-Term(iTRAQ4plex); C5(Methylthio); K11(iTRAQ4plex)

1.425 2 15.4 0.978 2 6.5 1.333 2 15 1.363 2 8.5 1.486 2 22 1.519 2 15.4 1.115 2 6.8 44 3.51 0 2 640.35883 -1.83 20.81 1279.71037

FFGEGTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.468 3 1.4 1.111 3 6.9 1.467 3 10.8 1.356 3 3.9 1.627 3 0.3 1.468 3 7.1 1.111 3 11 43 3.66 0 2 643.86621 1.28 40.82 1286.72515

FFGHGAEDSLADQAANEWGR

SAA1 serum amyloid A protein preproprotein [Homo sapiens]

6288 NP_954630 6 1 40316910 N-Term(iTRAQ4plex) 1.528 2 0.3 0.988 2 19.1 1.419 2 11.3 1.436 2 7.7 1.624 2 8.4 1.644 2 10.6 1.145 2 2.9 42 3.84 0 2 607.36731 0.03 50.63 1213.72649

FFHPEEWADLFQAAGAK FUCA1 tissue alpha-L-fucosidase precursor [Homo sapiens]

2517 NP_000138 2 1 119360348 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.643 2 0.9 0.949 2 3.4 1.535 2 1.8 1.618 2 1.6 1.667 2 3.3 1.756 2 0.2 1.085 2 1.4 42 3.93 0 2 578.86188 -0.52 32.83 1156.71648

FFLCQVAGDAK NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 2 5 115529482 N-Term(iTRAQ4plex); C4(Methylthio); K11(iTRAQ4plex)

1.217 1 0.981 1 1.134 1 1.156 1 1.277 1 1.302 1 1.126 1 41 3.65 0 2 684.81873 8.09 36.26 1368.63017

FFLTNGEIMTFEK MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 2 1 4557739 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.729 1 0.95 1 1.64 1 1.726 1 1.732 1 1.823 1 1.056 1 38 0 2 779.8457 -0.32 15.13 1558.68413

FFNANQWADIFQASGAK FUCA2 plasma alpha-L-fucosidase precursor [Homo sapiens]

2519 NP_114409 2 1 40068512 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.038 1 1.039 1 0.988 1 0.95 1 1.129 1 1.087 1 1.143 1 37 3.41 0 2 779.8457 -0.32 15.13 1526.68987

FFNVLTTNTDGK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 5 1 4503987 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.302 1 0.863 1 1.153 1 1.337 1 1.272 1 1.474 1 1.102 1 25 0 2 779.8457 -0.32 15.13 1542.68364

FFQVGLVSWGLYNPCLGSADK

C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 12 3 14550407 N-Term(iTRAQ4plex); C15(Methylthio); K21(iTRAQ4plex)

1.02 1 0.992 1 0.941 1 0.949 1 1.09 1 1.099 1 1.158 1 3.43 1 3 587.0224 -0.41 64.06 1759.05265

FFSAQTNR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 3 1 21361302 N-Term(iTRAQ4plex) 1.225 1 1.018 1 1.17 1 1.149 1 1.303 1 1.28 1 1.114 1 3.35 0 2 625.82928 0.52 45.82 1250.65129

FFSLLSGSLNSHGLELNADILGTDK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

4.496 3 17.3 1.043 3 6.5 4.305 3 39.2 4.2 3 3.8 4.681 3 37.4 4.662 3 0.8 1.104 3 0.7 82 6.74 0 4 949.02112 -11.37 29.51 1897.0364

FGCPWGVPPETIHPGNVQSR

MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 2 1 51477714 N-Term(iTRAQ4plex); C3(Methylthio)

3.317 1 0.923 1 3.035 1 3.29 1 3.341 1 3.622 1 1.101 1 77 4.16 0 2 867.43634 -0.28 33.06 1733.8654

FGFCPMAAHEEICTTNEGVMYR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

21 6 47132549;16933542

N-Term(iTRAQ4plex); C4(Methylthio); M6(Oxidation); C13(Methylthio)

5.179 2 39 0.974 2 17.1 4.721 2 29.4 4.848 2 48.3 5.518 2 30.3 5.666 2 49.3 1.169 2 0.8 73 6.01 0 2 938.44293 2.55 69.67 1875.87859

FGFCPMAAHEEICTTNEGVMYR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 6 47132549;16933542

N-Term(iTRAQ4plex); C4(Methylthio); C13(Methylthio)

4.461 4 22.8 1.076 4 6.3 4.136 4 24.1 4.176 4 14.3 4.745 4 31.7 4.749 4 17.4 1.131 4 3.9 65 3.53 0 2 700.85736 -16.12 21.62 1400.73711

FGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVK

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 4 2 47132620 N-Term(iTRAQ4plex); K44(iTRAQ4plex)

4.536 2 1.5 0.982 2 20.1 4.413 2 11 4.494 2 9 4.596 2 5.9 4.681 2 14.1 1.042 2 5.1 39 4.87 0 3 714.39301 1.93 21.81 2141.16446

FGGVLHLSDLDDDGLDEIIMAAPLR

GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 20 1 29171717 N-Term(iTRAQ4plex) 1.275 1 0.946 1 1.274 1 1.346 1 1.207 1 1.276 1 0.947 1 68 9.62 0 3 946.11694 -0.67 52.27 2836.33628

FGLFKPGEIAPLLFR OSCAR osteoclast-associated immunoglobulin-like receptor isoform 5 precursor [Homo sapiens]

126014 NP_573398 1 4 19557664 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.09 2 0 0.91 2 14.1 0.964 2 10.1 1.059 2 3.9 1.12 2 3.7 1.231 2 10.4 1.162 2 6.4 46 6.97 0 3 798.73938 3.19 49.82 2394.20359

FGLLDEDGK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

33 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.139 1 0.773 1 0.956 1 1.237 1 1.064 1 1.377 1 1.113 1 39 5.23 0 4 540.75696 -11.71 30.11 2160.006

FGLLDEDGKK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

4 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex); K10(iTRAQ4plex)

0.866 3 2.6 0.904 3 7.2 0.779 3 11.6 0.862 3 4.3 0.891 3 8.5 1.013 3 3.2 1.08 3 5.2 38 3.87 0 2 643.80841 -3.67 58.91 1286.61797

FGMHFCGGTLISPEWVLTAAHCLEK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 6 1 4505881 N-Term(iTRAQ4plex); C6(Methylthio); C22(Methylthio); K25(iTRAQ4plex)

1.371 1 0.996 1 1.314 1 1.319 1 1.422 1 1.427 1 1.082 1 33 3.53 0 3 610.6579 -4.65 44.78 1829.95914

FGMHFCGGTLISPEWVLTAAHCLEK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 55 1 4505881 N-Term(iTRAQ4plex); M3(Oxidation); C6(Methylthio); C22(Methylthio); K25(iTRAQ4plex)

1.002 1 1.02 1 0.948 1 0.929 1 1.077 1 1.055 1 1.135 1 33 3.18 0 2 721.38647 1.82 54.45 1441.76567

FGQTPVQER VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 1 1 223633991 N-Term(iTRAQ4plex) 1.093 1 1.033 1 1.068 1 1.034 1 1.155 1 1.117 1 1.081 1 32 3.13 0 2 529.31311 6.32 25.53 1057.61894

FGSALAVLDFNVDGVPDLAVGAPSVGSEQLTYK

GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 2 1 29171717 N-Term(iTRAQ4plex); K33(iTRAQ4plex)

1.04 5 52.1 0.727 5 43.8 0.989 4 11.5 1.135 4 39.2 0.986 5 21 1.298 5 20.4 1.098 4 11.4 60 8.84 0 4 1159.3042 -1.72 47.44 3475.91225

FGSGYVSGWGR F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 6 1 4503649 N-Term(iTRAQ4plex) 1.877 1 1.341 1 2.009 1 1.498 1 2.385 1 1.778 1 1.187 1 43 7.53 0 4 1094.5248 -4.28 39.33 4375.07729

FGSSLITVR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 6 1 29171717 N-Term(iTRAQ4plex) 1.171 1 0.846 1 1.001 1 1.182 1 1.162 1 1.373 1 1.161 1 41 3.43 0 2 751.39435 -4.39 33.13 1501.78142

FGSWMTDPLAPEGDNR OLFM1 noelin isoform 1 precursor [Homo sapiens]

10439 NP_055094 4 1 17136143 N-Term(iTRAQ4plex) 0.453 3 140.1 0.915 3 11.8 0.552 2 25.5 0.511 2 67.6 0.611 3 91.6 0.444 3 293.6 1.442 2 14 40 8.91 0 4 1094.5248 -4.28 39.33 4359.10268

FGSYCPTTCGIADFLSTYQTK

FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); C5(Methylthio); C9(Methylthio); K21(iTRAQ4plex)

0.369 1 0.932 1 0.31 1 0.332 1 0.403 1 0.433 1 1.302 1 34 3.12 0 2 650.37366 0.86 24.23 1299.74004

FHVELAAPSPELYSLHCPDR

MEGF8 multiple epidermal growth factor-like domains protein 8 precursor [Homo sapiens]

1954 NP_001401 XP_290821

2 1 145701025 N-Term(iTRAQ4plex); C17(Methylthio)

1.132 1 0.804 1 1.108 1 1.379 1 0.933 1 1.161 1 0.842 1 6.62 1 5 750.42755 2.03 41.47 3748.10865

FIAESK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.696 14 14.3 0.901 14 15.1 1.479 14 9.2 1.584 14 28 1.747 14 8.3 1.894 14 18.7 1.182 14 7.3 110 6.69 0 3 1077.6027 2.44 63.84 2154.2034

FICPLTGLWPINTLK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 150 1 153266841 N-Term(iTRAQ4plex); C3(Methylthio); K15(iTRAQ4plex)

1.459 12 13.3 0.906 12 18.7 1.299 12 15.9 1.418 12 26.7 1.501 12 20.3 1.664 12 18.6 1.129 12 9.5 110 7.94 0 3 826.10022 2.04 63.4 2476.28611

FIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIK

LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 4 1 4557892 N-Term(iTRAQ4plex); K17(iTRAQ4plex); M33(Oxidation); K37(iTRAQ4plex)

1.167 1 0.54 1 0.911 1 1.688 1 0.885 1 1.64 1 0.971 1 103 7.57 0 3 1227.5968 1.37 44.29 3680.77585

Page 14: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

FIEDVK OBSCN obscurin isoform a [Homo sapiens] 84033 NP_443075 NP_079144 XP_001129206 XP 001129220

1 2 58331253 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.535 16 7.7 0.99 16 11.7 1.486 16 14.8 1.427 16 8.2 1.737 16 11.4 1.629 16 11.1 1.126 16 3.5 97 6.44 0 2 887.43695 -4.96 35.28 1773.86662

FIIEGMEEAGSVALEELVEK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 16 1 21071039 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.708 2 1.7 0.804 2 23.9 1.422 2 16.6 1.769 2 7.1 1.667 2 8.6 2.075 2 15.1 1.173 2 7.9 88 7.6 1 3 1139.4558 -1.76 16.61 2277.90396

FIINDWVK SERPINE1 plasminogen activator inhibitor 1 isoform 2 precursor [Homo sapiens]

5054 NP_001158885 2 2 259155306 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.346 2 5.2 0.729 2 15.5 0.995 2 16.9 1.366 2 1.3 1.325 2 10.4 1.818 2 26.2 1.331 2 27.6 78 5.5 0 3 870.39667 0.28 55.83 2609.17893

FIIPGLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 26 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.435 12 9.7 1.06 12 19 1.368 12 19.3 1.321 12 3.6 1.548 12 19.5 1.545 12 7 1.131 12 6.9 78 5.8 0 2 989.88269 0.56 37.05 1978.74809

FIIPQIVK LDHB L-lactate dehydrogenase B chain [Homo sapiens]

3945 NP_002291 3 1 4557032 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.34 3 7.3 0.868 3 1.6 1.129 3 7.1 1.41 3 14.2 1.306 3 2.6 1.524 3 1.9 1.137 3 9.7 77 10.43 1 3 954.17786 0.65 43.43 2860.51902

FIIPSPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.731 13 14.1 1.047 13 9.4 1.634 13 28.8 1.603 13 12.2 1.86 13 25.5 1.792 13 11.6 1.114 13 2.8 76 5 0 2 757.41113 0.58 45.29 1513.81133

FIQSQDYQCSALMGGR CSF1R macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens]

1436 NP_005202 2 1 27262659 N-Term(iTRAQ4plex); C9(Methylthio)

1.19 12 6.8 0.986 12 9.3 1.171 12 8.7 1.139 12 6.9 1.303 12 9.6 1.306 12 12.8 1.131 12 2.4 75 5.04 0 3 1017.9354 -1.79 52.72 2034.86235

FIQVGVISWGVVDVCK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 219 1 67782358 N-Term(iTRAQ4plex); C15(Methylthio); K16(iTRAQ4plex)

1.485 14 10 1.023 14 22.1 1.444 14 25.7 1.41 14 4.2 1.561 14 20.2 1.558 14 7.9 1.118 14 4.9 73 5.43 0 2 756.90253 2.69 27.66 1512.78447

FISLGEACK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 16 1 115298678 N-Term(iTRAQ4plex); C8(Methylthio); K9(iTRAQ4plex)

1.134 2 12.4 0.978 2 7 1.056 2 7.9 1.079 2 15 1.189 2 9.7 1.215 2 16.8 1.126 2 1.7 73 6.78 0 3 1449.0934 -3.03 80.8 2897.19065

FIVQHTNPFNTWIGLTDSDGSWK

ASGR2 asialoglycoprotein receptor 2 isoform b [Homo sapiens]

433 NP_550435 2 4 18426875 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.161 2 9.3 0.737 2 24 0.928 2 19.7 1.26 2 4.1 1.094 2 19.2 1.486 2 4.6 1.179 2 0.5 72 4.66 0 2 683.35931 0.96 11.11 1365.71135

FKPTLSQQQK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

8 2 31542984;262050538

N-Term(iTRAQ4plex); K2(iTRAQ4plex); K10(iTRAQ4plex)

1.413 14 12 1.072 14 14.4 1.419 14 21.9 1.351 14 8.5 1.605 14 15.2 1.513 14 5.6 1.107 14 3.9 72 5.22 0 2 762.40588 -0.47 33.41 1523.79863

FLATTPNSLLVSWQPPR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

12 5 47132549;16933542

N-Term(iTRAQ4plex) 1.328 5 1.2 0.861 5 8.7 1.275 5 8.7 1.488 5 8 1.412 5 25.3 1.457 5 9.2 1.064 5 14.8 72 8.55 0 4 1210.0427 -9.39 32.88 2419.07876

FLCMDSALR ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 3 preproprotein [Homo sapiens]

11093 NP_620595 2 3 21265043 N-Term(iTRAQ4plex); C3(Methylthio)

1.868 1 1.005 1 1.747 1 1.739 1 1.998 1 1.988 1 1.143 1 70 3.91 0 2 1003.361 1.72 33.97 2005.71477

FLCTGGVSPYADPNTCR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 70 1 67782358 N-Term(iTRAQ4plex); C3(Methylthio); C16(Methylthio)

1.161 4 41.3 1.598 4 54.6 1.322 4 43.1 1.128 4 33.4 1.673 4 56.6 1.23 4 51.7 1.216 4 10.7 69 8.64 1 3 1092.2351 1.93 71.65 3274.69077

FLDMLIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); M4(Oxidation); K7(iTRAQ4plex)

1.779 3 13.5 0.941 3 12.6 1.717 3 4.1 1.646 3 5 1.918 3 7.5 1.839 3 7.3 1.117 3 2.2 65 9.21 0 3 863.44519 0.34 49.34 2588.31644

FLDQGLDDNYCR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 6 1 205277383 N-Term(iTRAQ4plex); C11(Methylthio)

1.468 4 8.5 0.879 4 23.9 1.199 4 13.8 1.605 4 11.1 1.288 4 23.4 1.727 4 10.8 1.074 4 7 64 4.9 0 3 737.9212 -10.64 26.55 1474.83359

FLDSNIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.252 2 13.1 1.017 2 8.1 1.216 2 7 1.196 2 15.1 1.308 2 10.9 1.287 2 19.1 1.076 2 3.9 64 5.87 1 3 1125.9719 -7.76 28.86 2250.92923

FLENEDR SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 1 1 189163538 N-Term(iTRAQ4plex) 1.5 12 13.3 0.898 12 22.7 1.284 12 27.6 1.591 12 16.7 1.484 12 17 1.761 12 18.3 1.151 12 6.3 62 5.12 0 2 1003.0242 -10.63 29.49 2005.04106

FLEPFDIDDHQQVHCPYDQLQIYANGK

C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

1 1 66347875 N-Term(iTRAQ4plex); C15(Methylthio); K27(iTRAQ4plex)

1.033 3 28.2 0.843 3 10.9 1.029 3 18.4 0.955 3 11.8 1.117 3 19.1 1.037 3 6.7 1.091 3 0.6 55 2.83 0 2 590.3233 -6.37 18.03 1179.63933

FLEQELETITIPDLR PLTP phospholipid transfer protein isoform c precursor [Homo sapiens]

5360 NP_001229849 4 3 339275807 N-Term(iTRAQ4plex) 1.365 2 7.5 1.089 2 19.3 1.338 2 15.8 1.229 2 3.4 1.519 2 19.1 1.395 2 0.2 1.135 2 3.2 55 0 2 509.25049 -1.02 10.11 1017.4937

FLEQQNQVLETK KRT72 keratin, type II cytoskeletal 72 isoform 2 [Homo sapiens]

140807 NP_001139698 3 5 226246665 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.439 8 15.8 1.005 8 15.9 1.363 8 21 1.401 8 9.2 1.516 8 27.3 1.625 8 6.2 1.155 8 8.5 54 2.78 0 2 557.78558 -1.24 8.43 1114.56389

FLEQQNQVLQTK KRT2;KRT1 keratin, type II cytoskeletal 2 epidermal [Homo sapiens];keratin, type II cytoskeletal 1 [Homo sapiens]

3849;3848 NP_000414;NP_006112

11 5 47132620;119395750

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.743 3 27.1 0.781 3 16.7 1.389 3 54 1.779 3 15.3 1.715 3 38.1 2.196 3 1.5 1.218 3 1.9 52 8.62 0 3 845.80292 0.95 58.03 2535.3942

FLHQDIDSGQGIR IGF2R cation-independent mannose-6-phosphate receptor precursor [Homo sapiens]

3482 NP_000867 2 1 119964726 N-Term(iTRAQ4plex) 1.186 14 20.5 0.958 14 23.8 1.106 14 20.2 1.053 14 14.1 1.251 14 27.4 1.211 14 14.6 1.115 14 5.6 52 3.95 0 3 838.89264 0.73 75.44 1676.77678

FLHVPDTFEGHFDGVPVISK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 160 1 70778918 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.209 16 10.9 0.995 16 5.4 1.082 16 12.6 1.12 16 14.5 1.253 16 11.5 1.282 16 10.7 1.167 16 4.4 52 4.67 0 2 704.87311 -1.41 52.66 1408.73894

FLLGSWLEQAR NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 2 1 66346698 N-Term(iTRAQ4plex) 1.609 3 7.8 0.977 3 6.8 1.501 3 15.8 1.457 3 6 1.682 3 16 1.721 3 0 1.156 3 3.2 51 3.54 0 2 547.79974 -0.91 10.05 1094.59111

FLLYGLSGR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 1 188528648 N-Term(iTRAQ4plex) 1.374 14 8.6 0.962 14 26.5 1.229 14 23.2 1.342 14 23.5 1.289 14 16 1.459 14 28.3 1.125 14 15.2 47 6.93 0 4 1070.2173 -0.31 57.1 3208.64199

FLNVLSPR IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 4 2 62243068 N-Term(iTRAQ4plex) 2.047 1 0.939 1 1.938 1 2.063 1 2.032 1 2.163 1 1.048 1 45 5.17 0 3 863.44519 0.34 49.34 2604.31162

FLNWIK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 4 2 295054188 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.486 8 5.2 0.983 8 12 1.41 8 9.4 1.416 8 5.4 1.58 8 7.4 1.582 8 6.3 1.132 8 3.7 45 3.82 0 3 406.85419 0.31 21.61 1218.55351

FLPEGCQPLVSSAVDR TREML1 trem-like transcript 1 protein precursor [Homo sapiens]

340205 NP_835468 2 1 30794266 N-Term(iTRAQ4plex); C6(Methylthio)

1.362 3 12.1 1.006 3 4.4 1.231 3 12.5 1.417 3 7.1 1.316 3 5.6 1.53 3 12.6 1.079 3 1.4 39 3.28 0 2 517.29932 0.21 30.06 1033.59136

FLQDYFDGNLK PDIA3 protein disulfide-isomerase A3 precursor [Homo sapiens]

2923 NP_005304 2 1 21361657 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.047 1 0.723 1 0.808 1 1.118 1 0.996 1 1.378 1 1.232 1 38 0 2 571.28149 7.47 16.33 1141.55571

FLQEQGHR C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 4 1 166197660 N-Term(iTRAQ4plex) 1.417 4 9.1 0.958 4 2.8 1.303 4 6.5 1.356 4 8.5 1.496 4 11.6 1.541 4 11.9 1.14 4 3.3 37 3.32 0 2 587.82135 1.44 40.56 1174.63542

FLTTAK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 6 1 115298678 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.652 6 4.5 0.934 6 2.6 1.502 6 8.4 1.582 6 6.7 1.712 6 2.7 1.78 6 4.8 1.114 6 6 35 2.92 0 2 562.75085 -0.09 11.59 1124.49443

FLVGPDGIPIMR GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 18 1 6006001 N-Term(iTRAQ4plex) 1.379 6 7.8 0.868 6 9.8 1.299 6 13.9 1.381 6 3.1 1.378 6 13.8 1.559 6 9.1 1.129 6 2.5 33 3.11 0 2 569.26898 0.43 25.65 1137.53191

FLVGPDGIPIMR GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 3 1 6006001 N-Term(iTRAQ4plex); M11(Oxidation)

1.679 1 1.031 1 1.348 1 1.307 1 2.063 1 2.001 1 1.531 1 32 5.76 1 4 954.17786 0.65 43.43 2876.50966

FLVNLVK AFM afamin precursor [Homo sapiens] 173 NP_001124 30 1 4501987 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.775 2 4.7 1.205 2 6.4 1.881 2 6.4 1.561 2 0 2.033 2 9.8 1.688 2 3.4 1.081 2 3.4 31 0 2 513.27802 -1.79 8.17 1025.54912

FMETVAEK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 20 1 355594753 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.304 1 0.874 1 1.152 1 1.317 1 1.292 1 1.478 1 1.122 1 30 0 2 434.73618 0.63 15.13 868.46507

FMETVAEK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 2 1 355594753 N-Term(iTRAQ4plex); M2(Oxidation); K8(iTRAQ4plex)

1.255 1 0.774 1 1.066 1 1.377 1 1.161 1 1.5 1 1.09 1 4.01 0 3 516.93927 1.52 12.05 1548.80326

FMPLSDVLYGR BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 2 1 168229159 N-Term(iTRAQ4plex) 1.3 1 0.961 1 1.187 1 1.235 1 1.363 1 1.419 1 1.148 1 3.09 0 2 602.81177 -0.56 13.19 1204.61626

FMQAVTGWK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 75 1 4557287 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.57 1 1.095 1 1.559 1 1.423 1 1.73 1 1.579 1 1.11 1 2.91 0 2 658.34088 0.29 22.71 1315.67449

FMQAVTGWK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 24 1 4557287 N-Term(iTRAQ4plex); M2(Oxidation); K9(iTRAQ4plex)

0.973 2 5.5 0.926 2 3 0.88 2 0.1 0.95 2 3.2 0.995 2 7.4 1.075 2 10.5 1.131 2 7.3 67 5.63 0 2 916.02667 0.78 55.73 1831.05144

FNALQYLR LUM lumican precursor [Homo sapiens] 4060 NP_002336 5 1 4505047 N-Term(iTRAQ4plex) 0.912 1 0.985 1 0.81 1 0.822 1 1 1 1.015 1 1.235 1 56 3.77 0 2 684.87134 7.64 16.75 1368.7354

FNAVLTNPQGDYDTSTGK C1QC complement C1q subcomponent subunit C precursor [Homo sapiens]

714 NP_001107573 20 1 166235903 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.032 1 1.112 1 1.024 1 0.921 1 1.156 1 1.039 1 1.128 1 46 4.22 0 3 440.54852 -0.52 15.02 1319.63102

FNHLGHIFTFTPQNNEFQLQLSPK

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.185 1 1.264 1 1.187 1 0.939 1 1.496 1 1.183 1 1.26 1 41 0 3 694.0946 -7.8 22.07 2080.26926

FNKPFVFLMIEQNTK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 7 1 189163538 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K15(iTRAQ4plex)

1.949 1 1.014 1 1.901 1 1.874 1 2.024 1 1.995 1 1.065 1 3.66 0 3 858.79236 -4.01 25.86 2574.36252

FNRPFLMIIVPTDTQNIFFMSK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 300 1 50659080 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.074 1 0.994 1 0.994 1 0.999 1 1.147 1 1.154 1 1.155 1 3.58 0 3 568.30402 13.94 18.62 1702.8975

FNRPFLMIIVPTDTQNIFFMSK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 110 1 50659080 N-Term(iTRAQ4plex); M7(Oxidation); K22(iTRAQ4plex)

1.133 2 3.9 0.713 2 43.8 0.923 2 12 1.296 2 30.6 1.035 2 15.1 1.453 2 27.4 1.121 2 3.1 83 5.46 0 2 968.95477 2.17 53.17 1936.90227

FNRPFLMIIVPTDTQNIFFMSK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 11 1 50659080 N-Term(iTRAQ4plex); M7(Oxidation); M20(Oxidation); K22(iTRAQ4plex)

1.152 1 1.022 1 1.071 1 1.048 1 1.259 1 1.231 1 1.175 1 65 4.84 0 2 709.42511 -5.33 23.03 1417.84294

FNSVPLTDTGHER CSF1 macrophage colony-stimulating factor 1 isoform a precursor [Homo sapiens]

1435 NP_757351 2 1 27262667 N-Term(iTRAQ4plex) 1.138 1 0.932 1 1.037 1 1.112 1 1.163 1 1.247 1 1.122 1 50 3.46 0 3 386.56995 3.55 18.1 1157.69529

FNTFIHEDIWNIR RNASE4 ribonuclease 4 precursor [Homo sapiens]

6038 NP_002928 2 1 4506557 N-Term(iTRAQ4plex) 1.139 1 1.11 1 1.113 1 1.002 1 1.292 1 1.163 1 1.161 1 31 0 2 518.34497 2.09 29.24 1035.68266

FPAIQNLALR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 4 1 4557417 N-Term(iTRAQ4plex) 1.043 2 6.5 0.763 2 5 0.878 2 5.3 1.151 2 10.4 0.961 2 3.4 1.26 2 8.4 1.095 2 2 5.09 0 3 711.73633 3.55 49.66 2133.19443

FPETLMEIEIPIVDHSTCQK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 13 1 21264357 N-Term(iTRAQ4plex); C18(Methylthio); K20(iTRAQ4plex)

0.986 1 0.943 1 0.938 1 0.995 1 0.978 1 1.037 1 1.043 1 46 5.72 0 4 1069.2769 0.77 78.59 4274.08559

FPETLMEIEIPIVDHSTCQK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 2 1 21264357 N-Term(iTRAQ4plex); M6(Oxidation); C18(Methylthio); K20(iTRAQ4plex)

1.248 1 1.354 1 1.369 1 1.011 1 1.568 1 1.158 1 1.145 1 37 4.36 0 3 663.61877 1.81 22.61 1988.84177

FPEVDVLTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 19 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.248 61 31.1 0.918 61 24.2 1.961 61 38.3 1.997 61 48 2.298 61 32.8 2.446 60 41.7 1.136 60 15.9 114 10.24 0 5 1081.2157 -1.05 42.61 3241.6395

FPLTNAIK CHI3L1 chitinase-3-like protein 1 precursor [Homo sapiens]

1116 NP_001267 1 1 144226251 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

2.989 10 13.1 1.129 10 7.8 2.812 10 23.1 2.584 10 12.7 3.243 10 20.9 2.843 10 16.9 1.133 10 2.6 87 6.38 0 2 799.4624 -1.08 47.43 1597.91692

FPLYNLGFGHNVDFNFLEVMSMENNGR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 26 3 156119625 N-Term(iTRAQ4plex) 2.222 39 11.5 0.933 39 12.1 1.909 39 19.2 2.118 39 11.7 2.29 39 15.8 2.413 39 11.9 1.123 39 5.1 80 5.8 0 3 526.6015 2.3 36.18 1577.78995

FPLYNLGFGHNVDFNFLEVMSMENNGR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 32 3 156119625 N-Term(iTRAQ4plex); M22(Oxidation)

2.446 12 44 0.989 12 9.9 2.327 12 41.3 2.391 12 38.1 2.455 12 30.3 2.571 12 38.2 1.104 12 6.8 80 4.98 0 3 526.6015 2.3 36.18 1593.77825

FPLYNLGFGHNVDFNFLEVMSMENNGR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 6 3 156119625 N-Term(iTRAQ4plex); M20(Oxidation); M22(Oxidation)

1.32 3 6.3 1.086 3 13.7 1.119 3 19.9 1.226 3 6.1 1.356 3 19.1 1.419 3 13 1.157 3 4.8 57 3.31 0 2 563.81848 -4.43 16.66 1126.63201

FPLYNLGFGNNLNYNFLENMALENHGFAR

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 149 1 133925809 N-Term(iTRAQ4plex) 1.387 5 1.5 0.983 5 9.1 1.286 5 4.5 1.316 5 3.6 1.46 5 3 1.492 5 3.1 1.094 5 1.4 34 0 2 393.7337 1.37 10.11 786.46013

FPLYNLGFGNNLNYNFLENMALENHGFAR

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 14 1 133925809 N-Term(iTRAQ4plex); M20(Oxidation)

135 9.92 0 3 1136.6342 0.23 67.66 2272.26103

FPPEEELQR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 1 1 4503011 N-Term(iTRAQ4plex) 132 9.96 0 3 1136.6342 0.23 67.66 2288.25528

FPSGTFEQVSQLVK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 46 2 32483410 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

131 10.65 0 3 1451.3159 2.38 80.88 2901.62456

FPSSQDHPLPSAER CRHBP corticotropin-releasing factor-binding protein precursor [Homo sapiens]

1393 NP_001873 2 1 47080099 N-Term(iTRAQ4plex) 126 8.66 0 3 1187.1912 0.24 53.71 2373.37827

FPTDQLTPDQER MPO myeloperoxidase precursor [Homo sapiens]

4353 NP_000241 2 1 4557759 N-Term(iTRAQ4plex) 124 6.34 0 2 915.51141 -3.07 23.25 1830.023

FPVEMTHNHNFR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 3 1 73858566 N-Term(iTRAQ4plex) 117 9.92 0 3 1461.7312 -1.75 62.3 2922.45536

FPVEMTHNHNFR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 3 1 73858566 N-Term(iTRAQ4plex); M5(Oxidation)

113 6.49 0 2 1185.1157 1.53 47.33 2369.22637

FQASVATPR MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 6 1 4557739 N-Term(iTRAQ4plex) 112 9.16 0 4 1442.0917 1.78 80.86 4324.26088

FQDLVDAVR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 4 1 40317626 N-Term(iTRAQ4plex) 112 6.47 0 2 862.96802 -1.27 46.87 1724.93071

FQEGQEEER F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 3 1 119395709 N-Term(iTRAQ4plex) 111 6.71 0 3 1082.9977 1.6 77.22 2164.98808

FQELLQDLEK GADD45GIP1

growth arrest and DNA damage-inducible proteins-interacting protein 1 [Homo sapiens]

90480 NP_443082 2 1 31543415 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

108 8.52 0 3 1084.0415 -0.27 45.36 2167.09453

FQFPGKPGIYTR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

107 9.97 0 3 1314.2065 1.84 44.27 2627.39214

FQGEWNLQPLPK DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

104 7.58 0 3 1084.0415 -0.27 45.36 2183.06865

FQGTSYDSCTTEGR MMP2 72 kDa type IV collagenase isoform b [Homo sapiens]

4313 NP_001121363 2 2 189217853 N-Term(iTRAQ4plex); C9(Methylthio)

97 6.47 0 3 1198.0245 4.59 74.72 2395.05937

FQILTLWLPDSLTTWEIHGLSLSK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

70 6 178557739;67190748

N-Term(iTRAQ4plex); K24(iTRAQ4plex)

95 7.45 0 4 1063.5304 0.78 75.87 3188.57851

FQLFGSPSGQK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

94 9.65 0 3 1457.3569 0.63 66.06 2913.71262

FQMIPLDPK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 2 1 40317626 N-Term(iTRAQ4plex); M3(Oxidation); K9(iTRAQ4plex)

93 9.64 0 4 1412.7114 3.27 41.89 2824.41811

FQNSAILTIQPK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 40 2 38016947 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

93 4.95 0 3 1126.5901 2.16 48.27 2252.16593

FQPTLLTLPR SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 31 1 73858568 N-Term(iTRAQ4plex) 92 7.39 0 3 925.0365 4.45 74.67 1849.06572

FQSHIIIR OLFM1 noelin isoform 1 precursor [Homo sapiens]

10439 NP_055094 2 1 17136143 N-Term(iTRAQ4plex) 92 5.52 0 2 814.43158 -0.72 89.49 1627.85588

FQSVFTVTR C1QC complement C1q subcomponent subunit C precursor [Homo sapiens]

714 NP_001107573 8 1 166235903 N-Term(iTRAQ4plex) 92 4.73 0 2 705.85083 -1.14 25.62 1410.69438

FQVDNNNR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex) 90 7.48 0 3 1152.577 -3.9 22.87 2304.14678

FSAEFDFR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 13 1 192447438 N-Term(iTRAQ4plex) 87 4.86 0 2 816.49951 -3.53 51.13 1631.99968

FSAICQGDGTWSPR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 58 1 4502503 N-Term(iTRAQ4plex); C5(Methylthio)

86 5.71 1 3 538.29535 1.79 20.01 1612.86138

FSCFQEEAPQPHYQLR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 12 2 221316614 N-Term(iTRAQ4plex); C3(Methylthio)

85 9.35 0 3 1029.5786 1.4 80.1 3086.72129

FSCKPGFTIVGPNSVQCYHFGLSPDLPICK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 82 1 62739186 N-Term(iTRAQ4plex); C3(Methylthio); K4(iTRAQ4plex); C17(Methylthio); C29(Methylthio); K30(iTRAQ4plex)

85 5.41 0 2 774.41486 -7.61 18.27 1547.82244

FSCMCPQGYQVVR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 2 1 86788015 N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio)

82 5.35 0 2 785.96252 1.42 17.96 1570.91777

FSDASYQSINIPVTQNMVPSSR

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 N-Term(iTRAQ4plex) 81 6.08 0 2 854.48029 1.31 66.7 1707.95329

FSDASYQSINIPVTQNMVPSSR

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); M17(Oxidation)

80 7.29 0 3 1064.5569 0.39 27.42 2128.10454

FSDEGTHESQISFTIEGPLTSFGLSNK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 18 1 105990532 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

79 5.57 0 3 885.96021 -0.68 39.68 1770.91074

FSEEACAVLTSPTFEACHR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 10 1 89191868 N-Term(iTRAQ4plex); C6(Methylthio); C17(Methylthio)

78 4.23 0 2 696.84839 0.05 83.86 1392.6895

FSEWGNNAFFYYFEHR BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 6 1 4557351 N-Term(iTRAQ4plex) 78 4.31 0 2 687.92249 2.13 21.18 1374.82915

FSFVCK REG1B lithostathine-1-beta precursor [Homo sapiens]

5968 NP_006498 1 2 10835248 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

77 8.08 0 4 1152.577 -3.9 22.87 2288.15737

FSHEEIAMATVTALR ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens]

226 NP_000025 2 2 4557305 N-Term(iTRAQ4plex) 75 3.8 0 2 610.36194 2.4 54.46 1219.7166

FSISATYDLGATLLK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 96 1 205277441 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

75 6.92 0 3 592.36505 -0.4 54.9 1775.0806

FSISGSYVLDQILPR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 16 1 21361302 N-Term(iTRAQ4plex) 74 5.83 0 3 933.41309 0.72 77.85 1865.81394

FSLDGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

73 5.11 0 3 492.27728 0.28 47.86 1474.81748

FSLVGIGGQDLNEGNR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 1 167614506 N-Term(iTRAQ4plex) 70 7.3 1 3 1154.2658 3.33 57.83 3460.78269FSLVSGWGQLLDR F7 coagulation factor VII isoform b

precursor [Homo sapiens]2155 NP_062562 4 2 10518503 N-Term(iTRAQ4plex) 69 6.77 0 3 1063.5304 0.78 75.87 3204.57199

FSMLVAAIQSAGLTETLNR TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex); M3(Oxidation)

69 6.6 1 3 1142.6171 8.79 19.26 2284.22898

FSPATHPSEGLEENYCR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 58 1 4505881 N-Term(iTRAQ4plex); C16(Methylthio)

69 10.49 0 3 1405.994 0.62 69.43 4215.96677

FSSCGGGGGSFGAGGGFGSR

KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 10 2 119395750 N-Term(iTRAQ4plex); C4(Methylthio)

68 4.34 0 2 774.41486 -7.61 18.27 1563.82646

FSSHVGGTLGQFYQEVLWGSPAASDDGR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

264 2 31542984;262050538

N-Term(iTRAQ4plex) 68 8.27 0 4 1211.9194 2.05 66.12 3633.74375

FSSHVGGTLGQFYQEVLWGSPAASDDGRR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

7 2 31542984;262050538

N-Term(iTRAQ4plex) 67 4.53 0 2 669.86157 1.1 28.76 1338.7155

FSSSSGYGGGSSR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 6 2 55956899 N-Term(iTRAQ4plex) 66 4.09 0 2 662.38019 1.51 16.05 1323.73967

FSTEYELQQLEQFK ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

66 12.13 0 4 1442.0917 1.78 80.86 4340.25258

FSTFLSLLEAADLK POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 2 4 209863034 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

65 4.83 0 2 670.83856 -1.29 27.63 1340.66716

FSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILR

KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

5 3 4504893;156231037

N-Term(iTRAQ4plex); C8(Methylthio); C24(Methylthio); C27(Methylthio)

64 5.39 0 3 899.10162 4.15 33.29 2695.29489

FSVPAGIVIPSFQALTAR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 23 1 105990532 N-Term(iTRAQ4plex) 62 4.3 0 2 852.95288 -3.66 20.04 1704.90605

Page 15: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

FSVSLK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 3 1 119392081 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

62 6.36 1 3 1217.6449 9.4 27.44 2434.27951

FSVVYAK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 34 1 156523970 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

62 4.32 0 2 629.86499 -0.72 43.97 1258.72246

FSYSSGHVHLSSENK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

61 3.74 0 3 406.22012 3.85 34.13 1216.64206

FTCACPDQFK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 13 2 295054188 N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio); K10(iTRAQ4plex)

61 8.38 0 3 1405.994 0.62 69.43 4231.96108

FTDHLK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 1 2 4826762 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

61 4.67 0 2 663.88867 6.07 16.46 1326.77007

FTDSENVCQER AFM afamin precursor [Homo sapiens] 173 NP_001124 19 1 4501987 N-Term(iTRAQ4plex); C8(Methylthio)

60 3.56 0 3 698.90759 0.02 87 1396.80791

FTEDAK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 17 1 50659080 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

60 4.23 0 2 624.8512 -6.21 19.71 1248.69512

FTFEYSR AFM afamin precursor [Homo sapiens] 173 NP_001124 3 1 4501987 N-Term(iTRAQ4plex) 59 5.57 0 3 1036.5118 3.28 40.59 2072.01505FTGFDAHYMAVDVDECK MASP1;MAS

P1;MASP1mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

4 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C16(Methylthio); K17(iTRAQ4plex)

59 4.02 0 2 492.27728 0.28 47.86 1490.81096

FTGFDAHYMAVDVDECKER MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

1 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C16(Methylthio); K17(iTRAQ4plex)

58 4.45 1 2 777.43982 -11.33 18.84 1553.87236

FTGSQPFGQGVEHATANK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 8 1 40317626 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

58 8.18 0 3 1547.354 -0.09 43.1 3093.702

FTIYNNMFCAGFHEGGR F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 6 1 4503649 N-Term(iTRAQ4plex); C9(Methylthio)

57 6.58 1 3 644.39758 -2.19 40.75 1931.1782

FTNIGPDTMR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

18 5 47132549;16933542

N-Term(iTRAQ4plex) 56 4.65 1 2 1184.6287 -11 24.35 2368.25005

FTNIGPDTMR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

4 5 47132549;16933542

N-Term(iTRAQ4plex); M9(Oxidation)

56 3 0 2 511.31097 1.43 13.55 1021.61388

FTPTETNK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 9 1 4502511 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

55 2.96 0 2 554.82697 -12.49 17.72 1108.66142

FTQVTPTSLSAQWTPPNVQLTGYR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

17 5 47132549;16933542

N-Term(iTRAQ4plex) 55 5.12 0 3 899.10162 4.15 33.29 2711.27817

FTVDRPFLFLIYEHR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 42 1 73858566 N-Term(iTRAQ4plex) 53 8.67 0 4 908.48779 1.64 81.63 3630.93325

FTVETPDK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 3 1 205277441 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

53 3.61 0 2 641.35266 3.99 23.71 1281.69805

FTVNNLAEPQK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

53 6.09 1 3 835.00732 1.47 24.81 1668.99321

FTVSVNVAAGSK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 54 1 133925809 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

53 4.67 0 2 449.58469 -0.76 40.73 1346.74175

FVCNDDVYSGPLK IGF2R cation-independent mannose-6-phosphate receptor precursor [Homo sapiens]

3482 NP_000867 2 1 119964726 N-Term(iTRAQ4plex); C3(Methylthio); K13(iTRAQ4plex)

52 3.86 0 2 636.35162 4.06 24.6 1271.6917

FVCNSGYK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 39 2 62739186 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

50 4.15 0 2 598.78583 -1.72 13.47 1196.56438

FVETHPEFIGIK CECR1 adenosine deaminase CECR1 isoform a precursor [Homo sapiens]

51816 NP_059120 2 2 29029550 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

50 4 0 2 629.34723 -16.69 19 1257.70683

FVFGTTPEDILR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 1 40317626 N-Term(iTRAQ4plex) 49 4.6 0 3 509.2623 0.94 59.1 1525.77434

FVMQEEFSR PDIA3 protein disulfide-isomerase A3 precursor [Homo sapiens]

2923 NP_005304 1 1 21361657 N-Term(iTRAQ4plex) 48 6.14 0 2 1164.6438 -1.69 48.22 2328.28032

FVSDYETHGAGFSIR NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 4 5 66864913 N-Term(iTRAQ4plex) 48 5.38 1 3 1154.2658 3.33 57.83 3476.78647

FVTAVGTQGAISK NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 2 5 66864913 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

47 3.77 0 2 599.31396 -2.15 40.46 1197.62065

FVTQAEGAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

46 3.23 0 2 596.8111 7.73 16.77 1192.59856

FVTVQATFGTQVVEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 6 1 115298678 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

46 4.18 1 3 743.04083 -0.48 29.48 2227.10794

FVTWIEGVMR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 104 1 4505881 N-Term(iTRAQ4plex) 45 6.99 0 4 1152.577 -3.9 22.87 2320.14663

FVTWIEGVMR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 9 1 4505881 N-Term(iTRAQ4plex); M9(Oxidation)

45 2.91 0 2 525.80505 -0.51 8.69 1050.60295

FVVTDGGITR CACNA2D1 voltage-dependent calcium channel subunit alpha-2/delta-1 precursor [Homo sapiens]

781 NP_000713 2 1 54112390 N-Term(iTRAQ4plex) 44 4.19 0 3 399.55896 0.55 11.51 1196.66425

FVYTPAMESVCGYFHR TIMP1 metalloproteinase inhibitor 1 precursor [Homo sapiens]

7076 NP_003245 4 1 4507509 N-Term(iTRAQ4plex); C11(Methylthio)

43 3.36 0 2 560.29156 -0.38 19.03 1119.57622

FWGFHDCTHQEDVAVICSG CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 1 1 5174411 N-Term(iTRAQ4plex); C7(Methylthio); C17(Methylthio)

42 5.17 0 2 951.04956 1.62 21.08 1901.09184

FWLEQGVDSSVFEALPK OAF out at first protein homolog precursor [Homo sapiens]

220323 NP_848602 2 1 30425438 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

41 6.14 0 4 680.37701 1.96 55.49 2718.48379

FWTSFFPK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 9 1 4557351 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

40 3.93 0 3 456.23541 2.64 28.18 1366.68674

FYAAGLVSWGPQCGTYGLYTR

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 16 1 41393602 N-Term(iTRAQ4plex); C13(Methylthio)

40 6.64 1 3 884.14441 2.75 64.66 2650.41867

FYISK ZDHHC13 palmitoyltransferase ZDHHC13 isoform 1 [Homo sapiens]

54503 NP_061901 6 1 47933346 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

39 2.93 0 2 453.24109 0.56 7.34 905.47447

FYNQVSTPLLR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 33 1 70778918 N-Term(iTRAQ4plex) 39 5.94 0 4 1405.994 0.62 69.43 4247.95815

FYPAGDVLR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex) 38 5.39 1 3 913.39862 0.15 76.22 2738.18131

FYTFLK GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 3 1 6006001 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

38 7.11 0 6 1427.5081 2.71 57.78 5707.02441

FYTIEILK PIP prolactin-inducible protein precursor [Homo sapiens]

5304 NP_002643 2 1 4505821 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

36 3.44 0 3 365.87637 -3.14 16.03 1095.61457

FYVVMWK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 5 40317626 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

36 3.02 0 2 636.35162 4.06 24.6 1287.68755

FYYIYNEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 21 1 115298678 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

35 0 2 431.74133 0.34 7.21 862.47545

FYYLIASETPGK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 15 1 21361302 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

35 0 2 468.27148 8.38 25.49 935.53569

GAASPVPPPLVRVAPSLFLGSAR

DUSP28 dual specificity phosphatase 28 [Homo sapiens]

285193 NP_001028747 XP_209509

1 1 75750526 N-Term(iTRAQ4plex) 34 3.1 0 2 554.80737 1.85 33.95 1108.60747

GADFQCFQQAR COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 2 2 110611233 N-Term(iTRAQ4plex); C6(Methylthio)

34 10.7 0 6 690.51898 1.02 58.1 4138.08703

GADVWFK S100A8 protein S100-A8 [Homo sapiens] 6279 NP_002955 4 1 21614544 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

34 0 2 554.80737 1.85 33.95 1124.59685

GADYSLR FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 1 1 4503689 N-Term(iTRAQ4plex) 34 4.85 1 4 523.31915 -1.83 40.77 2090.25478

GAFFPLTER PLTP phospholipid transfer protein isoform c precursor [Homo sapiens]

5360 NP_001229849 2 4 339275807 N-Term(iTRAQ4plex) 31 0 2 509.32422 -13.28 16.94 1017.64116

GAKTLSSPSNRPSGETSVPPPPAVGR

ATXN2L ataxin-2-like protein isoform D [Homo sapiens]

11273 NP_680781 1 5 27262651 N-Term(iTRAQ4plex); K3(iTRAQ4plex)

29 0 2 518.24353 -3.33 14.52 1035.47978

GALHNYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

28 2.76 0 3 370.50677 2.6 43.71 1109.50577

GALISDQWVLTAAHCFR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 18 3 14550407 N-Term(iTRAQ4plex); C15(Methylthio)

27 3.15 0 2 559.22723 8.27 27.75 1117.44719

GAPCSDAAGR CTBS di-N-acetylchitobiase precursor [Homo sapiens]

1486 NP_004379 4 1 4758092 N-Term(iTRAQ4plex); C4(Methylthio)

6.71 0 4 1547.354 -0.09 43.1 3109.69497

GAPVSVYQIVVEEERPR PTPRM receptor-type tyrosine-protein phosphatase mu isoform 2 precursor [Homo sapiens]

5797 NP_002836 4 2 157419150 N-Term(iTRAQ4plex) 6.01 1 5 977.68671 8.51 68.41 4884.40443

GAQLGGDKGDRMATSRPAAR

ZNF831 zinc finger protein 831 [Homo sapiens]

128611 NP_848552 XP_066058 XP_945150

1 1 123701326 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

5.8 2 5 766.61298 -0.56 42.44 3829.03577

GAQTLYVPNCDHR IGFBP6 insulin-like growth factor-binding protein 6 precursor [Homo sapiens]

3489 NP_002169 4 1 11321593 N-Term(iTRAQ4plex); C10(Methylthio)

4.48 1 4 621.85144 -0.58 39.57 2484.38393

GATLALTQVTPQDER MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 4 1 71274107 N-Term(iTRAQ4plex) 4.02 0 2 564.28754 -3.25 14.59 1127.5678

GATTSPGVYELSSR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex) 2.94 0 2 519.30103 -3.32 14.71 1037.59477

GATTTFSAVER DPT dermatopontin precursor [Homo sapiens]

1805 NP_001928 2 1 32307172 N-Term(iTRAQ4plex) 1.317 1 0.832 1 1.298 1 1.561 1 1.114 1 1.34 1 0.859 1 38 3.95 0 3 671.04248 0.07 62.99 2011.11289

GATYNIIVEALK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

49 5 47132549;16933542

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

11.665 1 0.617 1 9.979 1 16.16 1 8.889 1 14.395 1 0.891 1 4.71 2 5 880.05255 7.35 52.09 4396.23365

GATYNIIVEALKDQQR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.464 1 0.866 1 2.172 1 2.508 1 2.425 1 2.801 1 1.117 1 2.88 1 2 832.95978 -3.42 50.21 1664.91228

GAYPLSIEPIGVR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 116 1 4557485 N-Term(iTRAQ4plex) 1.362 1 1.122 1 1.509 1 1.345 1 1.382 1 1.232 1 0.916 1 3.83 1 4 710.62231 16.21 42.59 2839.46743

GAYQNNEIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.506 1 0.885 1 1.34 1 1.514 1 1.499 1 1.693 1 1.118 1 45 4.38 0 2 824.87219 0.13 45.58 1648.73711

GCGEQTMIYLAPTLAASR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

N-Term(iTRAQ4plex); C2(Methylthio)

0.741 1 0.947 1 0.702 1 0.741 1 0.741 1 0.783 1 1.057 1 43 5.45 0 4 738.62891 0.23 55.02 2951.4938

GCPAALPLSNLYETLGVVGSTTTQLYTDR

TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 4 1 4507467 N-Term(iTRAQ4plex); C2(Methylthio)

1.455 1 0.821 1 1.272 1 1.55 1 1.378 1 1.679 1 1.083 1 29 0 2 578.28003 -2.04 18.48 1155.55278

GCPDVQASLPDAK PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 20 1 156616294 N-Term(iTRAQ4plex); C2(Methylthio); K13(iTRAQ4plex)

1.7 1 0.974 1 1.551 1 1.593 1 1.805 1 1.854 1 1.164 1 2.79 0 2 707.35413 4.1 35.45 1413.70098

GCPTEEGCGER C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 10 1 45580688 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio)

0.953 1 0.86 1 0.864 1 1.004 1 0.909 1 1.057 1 1.053 1 55 0 2 612.82629 9.14 27.57 1224.64531

GDACDHDDDNDGIPDDKDNCR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 1 40317626 N-Term(iTRAQ4plex); C4(Methylthio); K17(iTRAQ4plex); C20(Methylthio)

0.944 1 0.885 1 0.866 1 0.978 1 0.915 1 1.033 1 1.056 1 41 3.99 0 2 581.81299 -0.56 33.84 1162.6187

GDACEGDSGGPFVMK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 32 1 4503635 N-Term(iTRAQ4plex); C4(Methylthio); K15(iTRAQ4plex)

1.032 1 0.919 1 0.921 1 1.002 1 1.059 1 1.152 1 1.15 1 32 4.02 0 2 827.87579 -3.79 28.03 1654.74431

GDACEGDSGGPFVMK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 14 1 4503635 N-Term(iTRAQ4plex); C4(Methylthio); M14(Oxidation); K15(iTRAQ4plex)

1.234 1 0.838 1 1.075 1 1.283 1 1.194 1 1.424 1 1.11 1 87 4.39 0 2 875.98737 0.39 42.9 1750.96745

GDACKDDFDHDSVPDIDDICPENVDISETDFR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 1 1 40317626 N-Term(iTRAQ4plex); C4(Methylthio); K5(iTRAQ4plex); C20(Methylthio)

1.174 1 0.918 1 1.007 1 1.097 1 1.244 1 1.355 1 1.236 1 80 5.14 0 2 830.42017 1.42 31.82 1659.83306

GDATVFFILPNQGK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 11 1 21361302 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.066 1 0.868 1 0.807 1 0.929 1 1.185 1 1.365 1 1.469 1 73 7.36 0 3 919.08374 -0.97 42.61 2755.23667

GDAVCTESGWRPLPSCEEK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 62 2 62739186 N-Term(iTRAQ4plex); C5(Methylthio); C16(Methylthio); K19(iTRAQ4plex)

1.581 2 25.3 0.973 2 25.2 1.492 2 36.8 1.533 2 10.8 1.639 2 40.1 1.684 2 13.9 1.098 2 3 71 5.27 0 2 894.50677 3.86 41.55 1787.99358

GDECQLCEVENR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 11 3 21450863 N-Term(iTRAQ4plex); C4(Methylthio); C7(Methylthio)

1.235 1 1.003 1 1.166 1 1.163 1 1.307 1 1.303 1 1.121 1 63 4.72 0 2 795.45557 1.18 44.6 1589.90386

GDEGTRGFNGPPGPIGLQGLPGPSGEK

COL11A2 collagen alpha-2(XI) chain isoform 3 preproprotein [Homo sapiens]

1302 NP_542410 3 3 111118968 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

1.56 1 1.016 1 1.557 1 1.533 1 1.587 1 1.562 1 1.019 1 57 4.62 0 3 748.72821 5.81 68.82 2244.17008

GDGTFVDAAASAGVDDPHQHGR

CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 6 2 330688397 N-Term(iTRAQ4plex) 1.108 2 0.5 1.025 2 8 1.051 2 2.1 1.026 2 5.9 1.192 2 4.8 1.164 2 3.1 1.135 2 2.7 54 4.66 0 2 989.02533 4.16 69.03 1977.04338

GDGWLTDPYVLTEVDGK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 4 1 21071039 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.132 1 0.99 1 1.04 1 1.051 1 1.212 1 1.225 1 1.166 1 51 4.26 0 2 853.93732 -1.7 46.76 1706.86736

GDIGETGVPGAEGPR ADIPOQ adiponectin precursor [Homo sapiens]

9370 NP_004788 6 1 4757760 N-Term(iTRAQ4plex) 1.121 1 0.789 1 0.952 1 1.207 1 1.053 1 1.335 1 1.106 1 49 5.66 1 3 639.0036 -2.08 19 1914.99625

GDKVWVYPPEK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 2 1 11321561 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K11(iTRAQ4plex)

1.863 1 1.091 1 1.766 1 1.619 1 2.128 1 1.951 1 1.205 1 48 5.54 0 3 770.41064 2.93 35.74 2309.21738

GDLYFANVEEK CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 6 3 358438315 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.095 2 9.6 0.999 2 4.8 1.031 2 12.7 1.032 2 7.9 1.159 2 11.4 1.16 2 6.6 1.124 2 1.3 46 3.58 0 2 598.34479 1.64 33.42 1195.6823

GDMFLVANLGTK BTD biotinidase precursor [Homo sapiens]

686 NP_000051 2 1 4557373 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.074 1 0.913 1 0.952 1 1.042 1 1.102 1 1.207 1 1.158 1 40 3.1 0 2 585.34271 -1.54 33.27 1169.67815

GDPTMSWNDINCEHLNNWICQIQK

LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 1 2 341915493 N-Term(iTRAQ4plex); C12(Methylthio); C20(Methylthio); K24(iTRAQ4plex)

1.014 1 0.81 1 0.821 1 1.015 1 1.014 1 1.252 1 1.234 1 39 3.77 0 2 621.8642 2.94 32.43 1242.72112

GDQDATMSILDISMMTGFAPDTDDLK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 18 1 115298678 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.136 1 0.876 1 0.994 1 1.136 1 1.135 1 1.297 1 1.142 1 38 2.9 0 2 679.87402 0.81 31.13 1358.74077

GDSGGAFAVQDPNDK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 21 1 41393602 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.135 1 0.801 1 0.967 1 1.207 1 1.078 1 1.346 1 1.115 1 3.5 0 2 669.90198 -0.58 31.36 1338.79668

GDSGGPLIVHK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 8 1 67782358 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.173 1 0.977 1 1.136 1 1.162 1 1.183 1 1.21 1 1.041 1 3.26 0 2 576.31293 0.72 34.39 1151.61858

GDSGGPLVCGGVLEGVVTSGSR

CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 4 1 42544239 N-Term(iTRAQ4plex); C9(Methylthio)

2.253 1 0.926 1 1.948 1 2.104 1 2.392 1 2.583 1 1.228 1 3.87 0 4 759.64453 -2.45 43.06 3035.5563

GDSPASSKPISINYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

1 5 47132549;16933542

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.559 1 0.961 1 1.406 1 1.464 1 1.65 1 1.718 1 1.173 1 38 0 2 554.841 -0.92 36.18 1108.67473

GDSPWQVVLLDSK PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 2 1 4506115 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.29 2 5.9 0.866 2 7.1 1.126 2 10.3 1.301 2 3.2 1.281 2 8.2 1.48 2 1.1 1.138 2 2.1 61 4.52 0 2 776.42609 0.54 41.4 1551.8449

GDSQSSWK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

43 4.1 1 2 929.02313 6.89 28.52 1857.03899

GDSSWTLARLYHPDSTELQPASSLTSGSPER

LRIG1 leucine-rich repeats and immunoglobulin-like domains protein 1 precursor [Homo sapiens]

26018 NP_056356 6 1 54607118 N-Term(iTRAQ4plex) 32 0 2 475.79056 -2.37 13.16 950.57384

GDSTFESK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 16 2 4503689 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.223 2 8.8 0.934 2 0.4 1.122 2 6.9 1.201 2 6.4 1.244 2 10.9 1.332 2 10.4 1.109 2 3.9 58 6.27 0 3 569.65509 0.46 45.21 1706.95072

GDSVVWYLFSAGNEADVHGIYFSGNTYLWR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 6 1 4557485 N-Term(iTRAQ4plex) 1.459 1 0.934 1 1.228 1 1.314 1 1.593 1 1.706 1 1.298 1 40 7.22 0 4 636.85089 -2.88 48.98 2544.38173

GDTALDMRGR RAD50 DNA repair protein RAD50 [Homo sapiens]

10111 NP_005723 2 1 19924129 N-Term(iTRAQ4plex); M7(Oxidation)

1.257 1 0.855 1 1.131 1 1.324 1 1.199 1 1.404 1 1.06 1 53 5.19 0 2 829.93445 -0.75 25.84 1658.86162

GDTSTIYTNCWVTGWGFSK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 8 1 78191798 N-Term(iTRAQ4plex); C10(Methylthio); K19(iTRAQ4plex)

1.314 1 0.969 1 1.219 1 1.259 1 1.367 1 1.411 1 1.121 1 51 6.29 0 3 937.13965 0.3 54.37 2809.40439

GDTYPAELYITGSILR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 15 1 110611237 N-Term(iTRAQ4plex) 2.601 4 16.2 0.777 4 14.6 2.125 4 37.5 2.743 4 3.7 2.459 4 21.1 3.103 4 6.1 1.157 4 6.7 104 5.96 0 2 1061.5647 -2.35 47.52 2122.12212

GDVFTMPEDEYTVYDDGEEK

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 6 1 88853069 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

2.742 11 16 0.968 11 6.3 2.476 11 28.2 2.691 11 27.1 2.793 11 19.8 2.951 11 18.4 1.103 11 4.4 92 4.4 0 2 699.90442 -4.8 28.09 1398.80913

GDVFTMPEDEYTVYDDGEEK

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 3 1 88853069 N-Term(iTRAQ4plex); M6(Oxidation); K20(iTRAQ4plex)

4.04 8 71.4 0.923 8 26.9 3.929 8 79.7 3.618 8 70.9 4.505 8 74.3 4.149 8 60.1 1.134 8 7.8 90 5.71 0 3 1090.5258 -7.14 25.53 2180.05954

GDVTLTFLPLSFWGK CD109 CD109 antigen isoform 3 precursor [Homo sapiens]

135228 NP_001153060 2 3 227430303 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.877 4 29.6 1.043 4 32.2 2.634 4 8.6 2.88 4 48.6 2.769 4 13.1 3.209 4 32.2 1.113 4 5.6 84 7.63 0 4 1046.5847 -0.94 33.38 2092.1625

GDYTLNNVHACAK C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 4 1 4557391 N-Term(iTRAQ4plex); C11(Methylthio); K13(iTRAQ4plex)

3.386 2 11.4 0.854 2 11.9 2.908 2 17.6 3.404 2 5.6 3.375 2 16.4 3.951 2 4.4 1.161 2 1.2 78 5.58 0 3 893.48816 1.9 70.99 1785.9697

GEACDIPHCTDNCGFPHR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 6 3 21450863 N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio); C13(Methylthio)

1.753 7 9.3 0.991 7 16.6 1.528 7 26.6 1.671 7 8.8 1.81 7 27.3 1.855 7 8.5 1.109 7 4.1 67 4.58 0 2 652.41132 -2.64 30 1303.81536

GEADAMSLDGGYVYTAGK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

3.376 2 11.6 0.905 2 7.4 2.987 2 15.8 3.3 2 8.3 3.447 2 14.7 3.808 2 7.2 1.154 2 1 63 4.82 1 3 546.34338 -1.76 34.42 1637.0156

GECHVPILEANVDAQPK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 4 1 13540563 N-Term(iTRAQ4plex); C3(Methylthio); K17(iTRAQ4plex)

2.706 4 7.5 0.86 4 4.7 2.491 4 5.5 2.853 4 7 2.725 4 17 2.889 4 18.6 1.025 4 9.7 60 7.25 0 3 1144.647 1.26 48.76 2288.28458

GECQAEGVLFFQGDR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 850 1 11321561 N-Term(iTRAQ4plex); C3(Methylthio)

3.979 4 23.5 0.952 4 20 3.64 4 37.3 3.962 4 11 4.042 4 34.7 4.399 4 11.2 1.093 4 3.2 59 4.22 0 2 682.91388 -0.71 46.52 1364.82048

GECVPGEQEPEPILIPR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 11 1 4502067 N-Term(iTRAQ4plex); C3(Methylthio)

4.585 1 0.917 1 4.186 1 4.565 1 4.604 1 5.02 1 1.1 1 55 3.22 0 2 588.85791 0.59 16.25 1176.70854

Page 16: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

GECWCVNPNTGK IGFBP2 insulin-like growth factor-binding protein 2 precursor [Homo sapiens]

3485 NP_000588 4 1 55925576 N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio); K12(iTRAQ4plex)

3.1 2 7.7 0.883 2 14.3 2.772 2 3.9 3.139 2 18.3 3.072 2 1.7 3.478 2 12.6 1.108 2 5.6 54 4.19 0 3 770.88416 -4.34 23.7 1540.76103

GEESEVTVGGLEPGR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 1 188528648 N-Term(iTRAQ4plex) 2.189 1 1.087 1 2.118 1 1.948 1 2.451 1 2.254 1 1.157 1 50 2.82 0 2 682.91388 -0.71 46.52 1380.81255

GEFVWK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 145 1 11321561 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

4.055 2 13.8 0.955 2 2.5 3.681 2 12.6 3.855 2 10.1 4.244 2 17.1 4.446 2 14.6 1.153 2 4.5 46 4.61 0 3 770.88416 -4.34 23.7 1524.77314

GEFYIGSK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 21 1 4557485 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

3.809 3 5 1.23 3 0.1 3.979 3 14.5 3.235 3 14.3 4.406 3 3.6 3.579 3 3.8 1.048 3 6.2 44 0 2 487.83121 6.43 19.03 974.65514

GEIFFFK MMP2 72 kDa type IV collagenase isoform b [Homo sapiens]

4313 NP_001121363 4 2 189217853 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.481 2 27.3 1.161 2 12.7 1.551 2 39.3 1.336 2 25.7 1.65 2 30.2 1.421 2 17.1 1.064 2 8.3 43 5.39 0 3 860.45135 2.11 46.13 2579.33951

GEIQNILQK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 7 1 78191798 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

3.597 3 34 0.885 3 10 2.792 3 14.7 4.291 3 8.3 3.146 3 8.1 4.835 3 6.2 1.127 3 2.1 43 7 1 3 793.4411 3.71 80.3 2378.30875

GELDCHQLADSFRE IGFBP4 insulin-like growth factor-binding protein 4 precursor [Homo sapiens]

3487 NP_001543 6 1 62243290 N-Term(iTRAQ4plex); C5(Methylthio)

2.747 1 0.99 1 2.596 1 2.623 1 2.87 1 2.9 1 1.106 1 39 3.27 0 2 648.8479 -11.79 16.65 1296.68852

GENLFAITDEGMDVPLAMEEWHHER

PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 6 1 70780384 N-Term(iTRAQ4plex) 2.236 2 51.9 1.095 2 5.5 2.163 2 52.4 1.976 2 59.1 2.52 2 45.3 2.301 2 51.7 1.165 2 6 39 2.94 0 2 537.33197 0.86 12.2 1073.65581

GENLFAITDEGMDVPLAMEEWHHER

PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 1 1 70780384 N-Term(iTRAQ4plex); M12(Oxidation)

1.655 1 0.853 1 1.415 1 1.659 1 1.651 1 1.935 1 1.166 1 35 5.2 0 3 860.45135 2.11 46.13 2563.34159

GEPGDPVNLLR FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 4 1 27754776 N-Term(iTRAQ4plex) 4.31 1 0.891 1 3.98 1 4.466 1 4.171 1 4.68 1 1.048 1 29 0 2 533.77252 8.6 26.07 1066.53777

GEPSIPSNR CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 2 2 28373119 N-Term(iTRAQ4plex) 1.192 7 6.1 1.18 7 14.2 1.27 7 22.8 1.129 7 6.6 1.344 7 13.2 1.241 7 13.1 1.09 7 15.1 114 6.23 0 2 940.04791 -0.35 73.36 1879.08855

GEQCVDIDECTIPPYCHQR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C4(Methylthio); C10(Methylthio); C16(Methylthio)

1.083 3 2.6 1.038 3 6.6 1.001 3 5.4 1.001 3 8.5 1.217 3 6.1 1.125 3 0.5 1.215 3 11.6 82 5.13 0 2 960.37299 -1.67 52.74 1919.7387

GEQIQLK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 3 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.203 6 4.6 0.996 6 17 1.145 6 19 1.17 6 9.9 1.254 6 13 1.299 6 13.7 1.106 6 6.2 77 4.08 0 2 667.3158 1.23 31.01 1333.61833

GESGGAVFLER C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 8 3 14550407 N-Term(iTRAQ4plex) 1.208 1 1.071 1 1.182 1 1.103 1 1.319 1 1.232 1 1.116 1 67 3.71 0 2 590.34381 -1.7 14.69 1179.68035

GETHEQVHSILHFK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 5 1 73858566 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.242 5 6.9 1.035 5 8.7 1.16 5 16.7 1.271 5 4.4 1.313 5 9.9 1.356 5 13.2 1.148 5 2 65 3.95 0 3 802.91901 -2.76 44.32 1604.8306

GETILENIEFLEDTDMK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 3 4507875 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.404 2 25.4 1.037 2 20.8 1.322 2 38.5 1.274 2 16.7 1.545 2 35 1.489 2 13.4 1.169 2 3.2 64 5.26 0 2 898.02972 -2.06 58.37 1795.05217

GEVGFVLVDNQR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex) 1.072 2 0.3 0.964 2 1.5 0.99 2 2.7 1.027 2 4.2 1.115 2 4.4 1.157 2 2.9 1.127 2 7.1 59 6.9 0 3 707.68689 -1.71 49.39 2121.04612

GEVLDNSFTGGICK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 32 1 169636415 N-Term(iTRAQ4plex); C13(Methylthio); K14(iTRAQ4plex)

1.143 8 2.6 1.012 8 8.3 1.062 8 9.7 1.063 8 1.6 1.227 8 5 1.186 8 5.1 1.135 8 5.5 59 3.96 0 2 720.75726 5.12 24.03 1440.50676

GEVLPLPEANFPSFPLPHHK HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 14 1 4504489 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.476 3 3.5 1.041 3 2.8 1.427 3 2.2 1.37 3 5.1 1.587 3 1.9 1.524 3 4.7 1.112 3 0.3 56 4.5 0 2 722.89307 -17.3 21.89 1444.77886

GEVPPR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 5 1 11321561 N-Term(iTRAQ4plex) 0.967 1 1.162 1 1.004 1 0.864 1 1.087 1 0.935 1 1.082 1 52 2.84 0 2 529.31476 -2.09 8.65 1057.62224

GEVQAMLGQSTEELR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 14 1 4557325 N-Term(iTRAQ4plex) 1.334 1 1.035 1 1.313 1 1.268 1 1.403 1 1.355 1 1.069 1 50 2.96 0 2 548.30951 -1.69 7.75 1095.61174

GEVQAMLGQSTEELR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 26 1 4557325 N-Term(iTRAQ4plex); M6(Oxidation)

1.312 2 14.3 0.97 2 20.5 1.232 2 6.8 1.271 2 27.5 1.359 2 1.9 1.401 2 22.5 1.103 2 4.9 48 0 2 510.30191 -0.99 20.8 1019.59654

GEWPWQVTLHTTSPTQR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 4 1 4503627 N-Term(iTRAQ4plex) 1.31 2 23.6 1.023 2 6.6 1.242 2 12.1 1.214 2 18.7 1.405 2 27.4 1.374 2 34.4 1.131 2 15 43 0 2 564.82898 0.31 19.65 1128.65068

GEWTCIAYSQLR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

13 6 47132549;16933542

N-Term(iTRAQ4plex); C5(Methylthio)

1.134 3 14.1 1.004 3 7.4 1.069 3 12.7 1.104 3 5.3 1.204 3 22.3 1.324 3 14 1.2 3 5.8 41 3.14 0 2 561.81512 -1.36 9.65 1122.62273

GEWTCKPIAEK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 6 47132549;16933542

N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex); K11(iTRAQ4plex)

1.08 2 1.3 0.975 2 9.6 1.008 2 6.2 1.033 2 3.3 1.127 2 5.9 1.156 2 3.6 1.119 2 0.3 26 0 2 554.23993 0.52 40.89 1107.47258

GEWVALNPLR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 8 2 62739186 N-Term(iTRAQ4plex) 1.022 1 0.944 1 0.99 1 1.049 1 0.997 1 1.056 1 1.007 1 64 4.58 0 2 871.36536 -2.53 20.9 1741.72344

GEYEEHLGILGPIIR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 1.367 1 0.974 1 1.282 1 1.317 1 1.416 1 1.454 1 1.104 1 50 3.95 0 2 781.92712 1.39 37.35 1562.84697

GEYFWEK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 8 1 89191868 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.168 1 1.261 1 1.028 1 0.816 1 1.611 1 1.278 1 1.567 1 39 8.47 0 4 946.45923 -0.48 52.6 3782.81508

GFCWCVDK IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 2 2 62243068 N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio); K8(iTRAQ4plex)

1.302 2 1.7 0.977 2 13.8 1.177 2 9.6 1.205 2 4.1 1.399 2 1.2 1.432 2 12.5 1.188 2 8.4 34 3.14 0 2 588.33948 1.14 38.5 1175.67168

GFEFSVPFTEMK TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 2 188528648 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.824 1 0.935 1 1.646 1 1.761 1 1.883 1 2.014 1 1.144 1 46 4.46 0 2 685.87958 -2.2 32.36 1370.75188

GFEPGVTNILK POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 1 4 209863034 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.6 1 0.929 1 1.465 1 1.577 1 1.622 1 1.746 1 1.107 1 44 3.63 0 3 574.68115 -0.16 63.62 1722.0289

GFEPTLEALFGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 79 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.605 1 0.901 1 2.313 1 2.568 1 2.639 1 2.93 1 1.141 1 2.99 0 2 620.84308 -2.21 34.44 1240.67888

GFFADYEIPNLQK BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 2 1 168229159 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.03 1 0.834 1 0.93 1 1.115 1 0.96 1 1.15 1 1.032 1 58 4.36 0 3 516.25977 -0.88 30.31 1546.76474

GFGGLTGQIVAALSTAK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 14 4 189181722 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.109 2 7.8 0.98 2 6.6 1.018 2 16 1.039 2 9.3 1.177 2 6.8 1.201 2 0.2 1.156 2 9.1 55 5.02 0 3 530.65222 -4.72 40.71 1589.94614

GFGGVQVSPPNENVAIYNPFRPWWER

AMY2A pancreatic alpha-amylase precursor [Homo sapiens]

279 NP_000690 XP_003960156

3 1 4502085 N-Term(iTRAQ4plex) 1.53 1 0.941 1 1.305 1 1.388 1 1.663 1 1.768 1 1.274 1 34 0 3 516.25977 -0.88 30.31 1562.76303

GFGSLNDEGEGEFWLGNDYLHLLTQR

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 16 1 4503689 N-Term(iTRAQ4plex) 1.267 17 20.4 0.996 17 19.1 1.129 17 24.7 1.202 17 26.6 1.334 17 17.7 1.47 17 17 1.174 17 16.7 109 10.7 0 3 1115.2537 0.5 66.87 3343.74643

GFLAYYQAVDLDECASR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

27 1 66347875 N-Term(iTRAQ4plex); C14(Methylthio)

1.297 14 4.8 0.907 14 6.6 1.147 14 7.9 1.28 14 6.6 1.321 14 8.7 1.465 14 10.1 1.144 14 5.1 93 9.37 0 3 722.35889 0.95 46.44 2165.06211

GFLLLASLR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 16 1 40317626 N-Term(iTRAQ4plex) 2.196 3 15.1 1.062 3 24.2 2.177 3 25.8 2.431 3 38.4 2.47 3 16.5 2.266 3 3.6 0.956 3 42.7 87 8.59 0 3 1115.2537 0.5 66.87 3359.74619

GFLLWYSGR PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 1 1 157653329 N-Term(iTRAQ4plex) 1.281 8 13.1 0.97 8 10.8 1.199 8 8.4 1.256 8 9.6 1.358 8 11 1.38 8 11.3 1.115 8 7.1 85 5 0 2 947.5238 0.04 62.16 1894.04033

GFMQTYYDDHLR APOC4 apolipoprotein C-IV precursor [Homo sapiens]

346 NP_001637 4 1 4502161 N-Term(iTRAQ4plex); M3(Oxidation)

1.412 2 3.4 0.904 2 12.3 1.156 2 12.4 1.279 2 24.9 1.525 2 13.7 1.687 2 1.4 1.319 2 26.4 75 5.09 0 3 1050.526 -0.24 70.43 2100.04538

GFNCESKPEAEETCFDK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

17 6 47132549;16933542

N-Term(iTRAQ4plex); C4(Methylthio); K7(iTRAQ4plex); C14(Methylthio); K17(iTRAQ4plex)

1.47 5 6.6 0.882 5 6.9 1.287 5 10.7 1.402 5 11.2 1.487 5 4.2 1.689 5 9 1.119 5 4.7 71 5.11 0 3 742.89612 1.6 16.67 1484.78418

GFPIKEDFLEQSEQLFGAKPVSLTGK

SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 3 2 115583663 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K19(iTRAQ4plex); K26(iTRAQ4plex)

1.274 3 43.9 0.994 3 74.2 0.909 3 33.3 1.082 3 43.2 1.174 3 46.4 1.518 3 29.8 1.291 3 11.8 68 5.05 0 3 1016.0735 2.3 67.98 3046.20591

GFQALGDAADIR TIMP1 metalloproteinase inhibitor 1 precursor [Homo sapiens]

7076 NP_003245 4 1 4507509 N-Term(iTRAQ4plex) 1.507 4 4.2 0.909 4 9.6 1.377 4 4.9 1.46 4 7.4 1.562 4 1.7 1.696 4 13.2 1.132 4 2.9 64 5.27 0 3 982.89038 -1.7 51.36 1964.77658

GFQHLLHTLNLPGHGLETR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 15 1 21361302 N-Term(iTRAQ4plex) 1.387 3 11.6 0.991 3 4 1.238 3 21.8 1.25 3 3.5 1.523 3 6.7 1.538 3 2.7 1.122 3 1.4 63 5.26 0 2 671.86536 -0.13 43.63 1342.72356

GFQQLLQELNQPR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 8 1 194018472 N-Term(iTRAQ4plex) 1.32 3 9.5 1.072 3 8.8 1.355 3 10 1.274 3 0.3 1.381 3 19.8 1.466 3 16.5 1.15 3 16.1 62 4.03 0 2 708.91339 -7.47 20.52 1416.825

GFQVVVTLR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 80 1 41393602 N-Term(iTRAQ4plex) 1.4 1 0.982 1 1.345 1 1.37 1 1.429 1 1.455 1 1.062 1 44 3.83 0 2 654.84143 6.96 25.97 1308.67558

GFSLDEATNLNGGLLR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 16 3 156119625 N-Term(iTRAQ4plex) 1.319 7 8.2 0.905 7 9.2 1.178 7 13.9 1.286 7 6.5 1.298 7 8.1 1.435 7 3.8 1.107 7 2 44 3.66 0 2 581.78308 -5.25 30.04 1162.56377

GFSSGSAVVSGGSR KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 19 2 47132620 N-Term(iTRAQ4plex) 1.261 2 23.1 1.115 2 1.2 1.249 2 22.9 1.12 2 24.1 1.418 2 22.1 1.271 2 23.3 1.135 2 0.8 42 6.09 0 3 813.38287 1.96 41.53 2438.13407

GFSTWLK MSN moesin [Homo sapiens] 4478 NP_002435 1 1 4505257 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.84 1 1.019 1 0.814 1 0.799 1 0.882 1 0.866 1 1.083 1 40 2.89 0 2 631.84674 1.79 16.42 1262.6862

GFTGSVADLAFAHLNSPQLACLDEAGNLFVWR

EDC4 enhancer of mRNA-decapping protein 4 [Homo sapiens]

23644 NP_055144 1 1 45827771 N-Term(iTRAQ4plex); C21(Methylthio)

1.332 1 0.969 1 1.247 1 1.287 1 1.374 1 1.419 1 1.102 1 34 0 2 495.7948 0.09 7.83 990.58232

GFVVAGPSR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 6 1 169636415 N-Term(iTRAQ4plex) 1.221 2 6.4 1.004 2 14.5 1.148 2 10.9 1.144 2 3.5 1.301 2 16.1 1.296 2 1.6 1.133 2 5.1 2.88 0 2 550.8042 0.14 47.82 1100.60112

GGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIK

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 107 1 4557391 N-Term(iTRAQ4plex); K36(iTRAQ4plex)

1.048 2 14.3 0.894 2 13.6 0.877 2 23.8 0.981 2 10 1.11 2 18.6 1.241 2 4.9 1.265 2 5.1 82 4.94 0 3 873.01233 -3.46 49.04 1745.0167

GGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIK

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 6 1 4557391 N-Term(iTRAQ4plex); M21(Oxidation); K36(iTRAQ4plex)

1.358 5 10.1 0.889 5 11.1 1.148 5 7.2 1.417 5 9.2 1.292 5 12.7 1.553 5 1.8 1.096 5 2.2 67 4.06 0 2 653.34186 -0.23 29.05 1305.67656

GGDVASMYTPNAQYCQMR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 5 1 78191798 N-Term(iTRAQ4plex); M7(Oxidation); C15(Methylthio)

1.338 1 1.014 1 1.343 1 1.325 1 1.351 1 1.332 1 1.006 1 64 4.98 0 2 685.88269 2.32 45.17 1370.7581

GGDVASMYTPNAQYCQMR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 4 1 78191798 N-Term(iTRAQ4plex); C15(Methylthio)

1.143 4 9.3 0.911 4 14 1.013 4 20.4 1.112 4 8.9 1.173 4 12.4 1.321 4 5.5 1.158 4 7.8 62 5.75 0 3 857.96936 -2.51 58.65 1714.93338

GGEGTGYFVDFSVR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 87 1 4504489 N-Term(iTRAQ4plex) 1.247 1 0.955 1 1.145 1 1.2 1 1.293 1 1.354 1 1.129 1 57 4.5 0 2 851.95148 2.08 53.42 1702.89568

GGETAQSADPQWEQLNNK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 20 1 73858566 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.05 2 16.8 0.911 2 9.8 1.058 2 16.4 1.161 2 6.5 0.948 2 27.5 1.041 2 17.4 0.896 2 10.7 33 3.2 0 2 610.8064 -1.08 31.8 1220.60759

GGGAGFISGLSYLELDNPAGNK

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 20 1 45580688 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.878 1 0.77 1 1.77 1 2.301 1 1.553 1 2.018 1 0.877 1 3.94 1 3 459.57175 -5.28 25 1376.70069

GGGAGFISGLSYLELDNPAGNKR

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 8 1 45580688 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.357 1 1.032 1 1.314 1 1.273 1 1.443 1 1.399 1 1.099 1 58 4.28 0 2 799.4101 -0.73 37.78 1597.81291

GGGALLGDR C1R;C1RL complement C1r subcomponent precursor [Homo sapiens];complement C1r subcomponent-like protein precursor [Homo sapiens]

715;51279 NP_001724 XP_930935 XP_935774;NP_057630

4 2 66347875;289547636

N-Term(iTRAQ4plex) 0.994 1 0.936 1 0.911 1 0.973 1 1.013 1 1.083 1 1.112 1 31 0 2 574.8656 -3.69 24.42 1148.72392

GGGFGGGSSFGGGSGFSGGGFGGGGFGGGR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 6 1 47132620 N-Term(iTRAQ4plex) 1.322 1 1.004 1 1.213 1 1.208 1 1.437 1 1.432 1 1.185 1 77 7.5 0 3 1046.4579 -1.53 48.61 3137.3591

GGGGGGYGSGGSSYGSGGGSYGSGGGGGGGR

KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 18 2 119395750 N-Term(iTRAQ4plex) 1.287 1 0.97 1 1.196 1 1.233 1 1.34 1 1.381 1 1.12 1 44 3.22 0 2 523.36267 -4.11 22.01 1045.71807

GGGGSFGYSYGGGSGGGFSASSLGGGFGGGSR

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex) 1.199 1 0.931 1 1.037 1 1.114 1 1.278 1 1.372 1 1.232 1 42 3.15 0 2 690.88635 0.73 55.93 1380.76543

GGGQAANALAFGNSWQEETRPGCGATEPGDCPK

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C23(Methylthio); C31(Methylthio); K33(iTRAQ4plex)

1.189 1 0.841 1 1.032 1 1.227 1 1.156 1 1.375 1 1.121 1 37 3.83 0 2 749.90411 -0.86 47.2 1498.80095

GGGRGGPGITWAEAGPGAPGGLSPESGR

PDLIM2 PDZ and LIM domain protein 2 isoform 2 [Homo sapiens]

64236 NP_067643 1 1 311771772 N-Term(iTRAQ4plex) 1.236 2 15.7 0.9 2 11.6 1.094 2 20.4 1.216 2 8.7 1.257 2 22.1 1.396 2 10.4 1.149 2 1.7 33 5.13 0 3 617.33606 0.38 34.47 1849.9896

GGISGYTLR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex) 2.397 1 0.935 1 2.053 1 2.195 1 2.586 1 2.766 1 1.26 1 3.72 1 3 754.68939 4.3 18.59 2262.05362

GGNQLYCVK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 1 1 169636415 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

1.181 1 0.882 1 1.025 1 1.161 1 1.199 1 1.359 1 1.17 1 59 3.9 0 2 634.87744 2.56 32.38 1268.74761

GGSASTWLTAFALR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 13 2 38016947 N-Term(iTRAQ4plex) 0.829 1 0.958 1 0.741 1 0.773 1 0.882 1 0.921 1 1.191 1 84 6.26 0 3 512.64227 -1.05 44.39 1535.91227

GGSGGGGSISGGGYGSGGGSGGR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 10 2 47132620 N-Term(iTRAQ4plex) 0.847 1 1.151 1 0.885 1 0.769 1 0.937 1 0.813 1 1.058 1 51 5.3 0 3 575.66907 -0.14 53.54 1724.99265

GGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGK

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex); K40(iTRAQ4plex)

6.485 1 0.876 1 5.72 1 6.528 1 6.448 1 7.359 1 1.127 1 23 0 2 386.28217 -0.32 40.93 771.55705

GGSGGSYGGGGSGGGYGGGSGSR

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 12 2 55956899 N-Term(iTRAQ4plex) 1.32 1 1.161 1 1.512 1 1.302 1 1.34 1 1.154 1 0.886 1 3.92 0 4 763.67517 -0.94 80.38 3051.67885

GGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSR

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex) 1.039 1 0.943 1 0.924 1 0.98 1 1.096 1 1.161 1 1.186 1 4.95 0 3 665.06885 2.1 57.88 1993.19199

GGSIQQYIYK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 5 4 189181722 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.558 1 0.923 1 0.491 1 0.531 1 0.582 1 0.63 1 1.186 1 140 8.29 0 2 1238.5304 0.29 39.91 2476.05351

GGSISGGGYGSGGGK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.912 3 8.5 1.068 3 7.6 0.767 3 14.6 0.756 3 0.4 1.07 3 7.1 1.054 3 1.7 1.407 3 1.3 134 6.97 0 2 926.43707 -4.01 25.79 1851.86687

GGSSSGGGYGSGGGGSSSVK

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

0.825 2 23.3 1.011 2 10.3 0.731 2 17 0.724 2 6.6 0.924 2 38.3 0.914 2 27.2 1.263 2 20.3 112 8.93 0 3 1256.1906 3.58 50.21 2511.36417

GGSTSYGTGSETESPR FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 22 2 4503689 N-Term(iTRAQ4plex) 0.732 1 0.877 1 0.546 1 0.623 1 0.827 1 0.944 1 1.515 1 109 4.64 0 2 841.88232 6.98 26.99 1682.75737

GGTLGTPQTGSENDALYEYLR

CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 8 1 156627579 N-Term(iTRAQ4plex) 0.779 2 1 1.168 2 8.5 0.757 2 2.6 0.648 2 5.9 0.933 2 4.4 0.799 2 4.1 1.233 2 1.8 103 4.04 0 2 703.84839 -6.95 24.86 1406.70598

GGVNDNFQGVLQNVR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 11 1 40317626 N-Term(iTRAQ4plex) 0.722 8 17.1 1.008 8 22.2 0.657 8 22.6 0.617 8 7.5 0.839 8 23.4 0.782 8 9.9 1.253 8 6.7 99 6.07 0 2 835.43207 2.7 17.74 1669.85185

GGYTLVSGYPK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 437 1 11321561 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.844 4 4.8 1.164 4 2.4 0.836 4 7.7 0.764 4 10.9 1.002 4 10.9 0.852 4 2.5 1.179 4 7.5 94 6.62 0 3 1143.0886 -2.27 45.77 2285.17655

GHCQLGQK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 1 1 169636415 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

0.754 1 46.215 1 35.592 1 0.77 1 90 7.01 0 3 960.50171 1.01 80.81 2879.49057

GHGATNDLTFTEEVDMK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 29 1 133925809 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

0.741 6 22.7 1.083 6 5.9 0.695 6 37.4 0.707 6 34.6 0.677 6 15.5 0.757 6 25.8 1.081 6 16.5 88 5.71 0 3 1180.5686 -2.27 39.93 2360.13114

GHGEDHCQFVDSFLDGR ABI3BP target of Nesh-SH3 precursor [Homo sapiens]

25890 NP_056244 NP_079077

2 1 33667044 N-Term(iTRAQ4plex); C7(Methylthio)

0.889 15 8.6 0.949 15 24.6 0.801 15 25.7 0.843 15 19.1 1.003 15 20.4 1.056 15 24.8 1.305 15 21.2 85 7.43 0 3 795.42236 0.65 74.09 2384.24851

GHIYQGSEADSVFSGFLIFPSA

C1QA complement C1q subcomponent subunit A precursor [Homo sapiens]

712 NP_057075 2 1 7705753 N-Term(iTRAQ4plex) 0.986 5 29.2 0.918 5 2.9 0.742 5 29.6 0.831 5 36.7 1.123 5 23.5 1.259 5 30.4 1.541 5 3.2 84 7.67 0 3 795.42236 0.65 74.09 2400.24002

GHLFLQTDQPIYNPGQR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

146 6 178557739;67190748

N-Term(iTRAQ4plex) 0.85 7 18.7 0.937 7 6.8 0.657 7 29.3 0.768 7 14.4 0.853 7 14.1 0.912 7 10.7 1.189 7 19.6 82 5.21 0 2 767.89478 -0.47 21.21 1534.78227

GHMLENHVER ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 4 3 156119625 N-Term(iTRAQ4plex); M3(Oxidation)

1 19 13.8 0.897 19 15.9 0.857 19 17.1 0.925 19 22.6 1.056 19 17.5 1.144 19 10.7 1.222 19 9.9 79 6.15 0 3 695.745 2.2 67.17 2085.22373

GHVLFRPTVSQQQSCPTCSTSLLNGHFK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 5 2 156119625 N-Term(iTRAQ4plex); C15(Methylthio); C18(Methylthio); K28(iTRAQ4plex)

0.827 7 8.9 0.997 7 6.4 0.75 7 22.4 0.714 7 7.7 0.906 7 17.2 0.904 7 6.7 1.325 7 2.8 74 4.22 0 2 660.40375 -1.71 30.43 1319.79802

GHYFWMLSPFSPPSPAR PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 4 4 189181722 N-Term(iTRAQ4plex) 1.067 5 6.6 1.085 5 13.1 0.956 5 8.3 0.835 5 16.9 1.212 5 12.7 1.118 5 2.5 1.361 5 6.1 73 4.07 0 3 449.24469 0.19 35.74 1345.71745

GIDQNMFQK GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 3 1 4758460 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.762 2 41.7 1.104 2 17.3 1.227 2 21.8 1.111 2 4.4 2.454 2 69.6 2.224 2 48.1 2.001 2 43.1 71 5.05 1 4 1322.7116 4.39 39.9 2644.41582

GIEILNQVQESLPELSNHASILIMLTDGDPTEGVTDR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 26 3 156119625 N-Term(iTRAQ4plex) 0.674 4 3.8 0.998 4 7.9 0.62 4 2.9 0.59 4 14.7 0.732 4 5.5 0.72 4 5.7 1.238 4 6.7 59 4.69 0 3 755.37177 -3.43 29.54 1509.73743

GIEILNQVQESLPELSNHASILIMLTDGDPTEGVTDR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 6 3 156119625 N-Term(iTRAQ4plex); M24(Oxidation)

0.874 5 18.8 0.981 5 22.1 0.73 5 35 0.744 5 18.3 1.001 5 31.1 1.02 5 14.3 1.362 5 3 53 4.01 0 2 699.35321 3.68 27.89 1397.69853

GIETGSEDLEILPNGLAFISSGLK

PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 1 1 19923106 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

4.921 1 0.916 1 2.784 1 3.041 1 6.643 1 7.255 1 2.386 1 49 7.84 1 4 835.9649 1.86 75.18 3340.83779

GIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

4 6 47132549;16933542

N-Term(iTRAQ4plex); C7(Methylthio); K48(iTRAQ4plex)

0.755 5 6.7 0.967 5 8.7 0.678 5 15.4 0.669 5 10 0.791 5 4.2 0.836 5 13 1.169 5 3.2 45 4.26 0 2 655.34497 -3.21 19.18 1309.68266

GIIALR ATP5S ATP synthase subunit s, mitochondrial isoform a precursor [Homo sapiens]

27109 NP_001003803 1 1 51558774 N-Term(iTRAQ4plex) 0.621 1 0.996 1 0.606 1 0.608 1 0.633 1 0.635 1 1.044 1 40 0 2 569.30499 0.55 30.61 1137.60271

GIISALLVPPETEEAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 37 1 105990532 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.886 1 1.062 1 0.741 1 0.698 1 1.087 1 1.023 1 1.466 1 4.14 1 3 508.2977 -3.05 17.17 1522.87854

GILAADESTGSIAK ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens]

226 NP_000025 2 3 4557305 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.815 2 29.8 0.994 2 5.9 0.731 2 40.1 0.735 2 33.6 0.893 2 27.2 0.898 2 21 1.221 2 12 2.99 0 2 496.28036 -0.63 16.91 991.55345

GILTVDELLAIR LAMP2 lysosome-associated membrane glycoprotein 2 isoform A precursor [Homo sapiens]

3920 NP_002285 2 3 4504957 N-Term(iTRAQ4plex) 1.352 1 1.441 1 1.741 1 1.208 1 1.561 1 1.083 1 0.897 1 4.95 1 5 727.55432 -10.05 43 3633.7425

GIQVEIYSFPK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 3 2 4507875 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.476 1 0.98 1 1.345 1 1.373 1 1.576 1 1.609 1 1.172 1 3.83 1 4 880.67572 -17.3 51.87 3519.68105

GIQVELYSFPR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 2 4507875 N-Term(iTRAQ4plex) 1.434 1 0.801 1 1.229 1 1.535 1 1.354 1 1.691 1 1.102 1 3.44 1 3 737.36896 -19.33 39.55 2210.09232

GISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSR

SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 46 2 115583663 N-Term(iTRAQ4plex) 1.579 2 17.3 0.912 2 21.1 1.416 2 30.3 1.552 2 8.8 1.611 2 25.3 1.765 2 4 1.137 2 4.7 63 4.02 0 2 768.40735 -1.48 36.36 1535.80742

GISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSR

SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 2 2 115583663 N-Term(iTRAQ4plex); M35(Oxidation)

1.468 1 1.049 1 1.397 1 1.332 1 1.61 1 1.536 1 1.153 1 58 4.16 0 2 709.43506 -2.06 33.56 1417.86284

GISMLNK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 6 1 133925809 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.53 2 0.9 0.954 2 9.5 1.4 2 4.1 1.469 2 5.4 1.589 2 6.8 1.667 2 2.7 1.135 2 2.7 47 4.66 0 3 489.92929 0.14 41.75 1467.77414

GISTSAASPAVGTVGMDMDEDDDFSK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); M18(Oxidation); K26(iTRAQ4plex)

1.331 1 0.933 1 1.224 1 1.311 1 1.35 1 1.447 1 1.103 1 46 3.99 0 2 701.29034 1.13 47.99 1401.57341

GISTSAASPAVGTVGMDMDEDDDFSK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 28 1 105990532 N-Term(iTRAQ4plex); M16(Oxidation); M18(Oxidation); K26(iTRAQ4plex)

1.05 1 0.926 1 0.933 1 1.007 1 1.091 1 1.178 1 1.169 1 42 5.74 0 4 874.42194 -0.94 63.5 3494.66591

GITEPPFGIFVFNK DSG2 desmoglein-2 preproprotein [Homo sapiens]

1829 NP_001934 2 1 116534898 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.035 1 0.851 1 0.924 1 1.086 1 0.992 1 1.166 1 1.074 1 31 3.46 0 2 738.38458 0.51 33.21 1475.76189

GIVAAFYSGPSLSDK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 10 1 29171717 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.234 1 0.856 1 1.082 1 1.264 1 1.208 1 1.412 1 1.117 1 5.65 0 4 576.56232 -4.89 17.34 2303.22744

GIVTDSVR NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 2 1 115298674 N-Term(iTRAQ4plex) 1.078 1 0.947 1 0.993 1 1.049 1 1.106 1 1.169 1 1.114 1 3.05 0 2 638.8374 1.64 23.57 1276.66753

GIYGTISR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 N-Term(iTRAQ4plex) 0.936 1 1.035 1 0.93 1 0.898 1 0.974 1 0.942 1 1.048 1 4.88 0 3 739.72076 2.53 53.8 2217.14774

GKEESLDSDLYAELR PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 128 1 4505981 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

51 7.35 0 3 807.05817 -1.06 31.42 2419.16562

GKEGWIHTVCINGR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 2 1 62739186 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C10(Methylthio)

60 5.18 0 2 790.93744 0.05 21.05 1580.8676

Page 17: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

GKITDLIKDLDSQTMMVLVNYIFFK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 5 1 50659080 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K8(iTRAQ4plex); M15(Oxidation); M16(Oxidation); K25(iTRAQ4plex)

0.583 4 10.7 1.091 4 8.7 0.635 4 4.9 0.559 4 20.5 0.611 4 7.3 0.538 4 2.6 1.076 4 13.9 125 7.18 0 4 1344.7355 0.59 58.76 2688.4601

GKVVGLIQDLKPNTIMVLVNYIHFK

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 6 1 205277441 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex); K25(iTRAQ4plex)

0.339 1 1.367 1 0.345 1 0.252 1 0.458 1 0.335 1 1.326 1 89 7.99 0 3 1203.2451 2.69 63.35 3607.7208

GLASANVDFAFSLYK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 130 1 73858564 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.66 1 1.009 1 0.734 1 0.727 1 0.592 1 0.587 1 0.807 1 82 5.72 0 3 588.03174 1.39 81.42 1762.08066

GLCVATPVQLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

60 6 178557739;67190748

N-Term(iTRAQ4plex); C3(Methylthio)

0.554 4 8.6 0.955 4 15.4 0.498 4 7 0.55 4 16.7 0.59 4 13.2 0.627 4 14.3 1.229 4 13.6 79 5.76 0 3 1014.5161 2.61 52.64 2028.0214

GLEEELQFSLGSK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

240 6 178557739;67190748

N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.715 3 31.5 1.034 3 12.7 0.606 3 5 0.567 3 7.7 0.852 3 10.3 0.811 3 41.7 1.163 3 28 77 6.41 0 3 1119.5903 3.94 60.14 2238.16056

GLESQTK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

23 6 178557739;67190748

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.718 9 20.5 1.062 9 4.1 0.728 9 23.2 0.63 9 22.4 0.77 9 29.4 0.709 9 24.3 1.113 9 3.3 75 4.63 0 2 736.93188 0.13 26.72 1472.85735

GLETSLAECTFTK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 36 1 119392081 N-Term(iTRAQ4plex); C9(Methylthio); K13(iTRAQ4plex)

0.499 2 10.5 0.947 2 12.5 0.464 2 21.5 0.49 2 8.9 0.508 2 12.1 0.536 2 0.3 1.094 2 9.2 60 4.32 0 2 958.51318 -1.74 55.37 1916.01946

GLEVTITAR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 49 1 115298678 N-Term(iTRAQ4plex) 0.488 1 1.044 1 0.444 1 0.425 1 0.553 1 0.53 1 1.247 1 57 3.87 0 2 588.03174 1.39 81.42 1746.08953

GLFDEYGSK HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 2 1 4507677 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.517 4 5.7 1.017 4 12.7 0.496 4 5.4 0.472 4 8.2 0.549 4 3.7 0.564 4 7.2 1.159 4 6.6 56 5.95 0 3 536.65271 2.25 43.71 1607.94358

GLFIIDGK PRDX2 peroxiredoxin-2 isoform a [Homo sapiens]

7001 NP_005800 2 1 32189392 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.499 1 0.803 1 0.377 1 0.47 1 0.522 1 0.65 1 1.384 1 45 0 2 451.21692 -1.59 40.65 901.42656

GLFQVVSGGMVLQLQQGDQVWVEK

C1QA complement C1q subcomponent subunit A precursor [Homo sapiens]

712 NP_057075 26 1 7705753 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

0.764 1 0.604 1 0.632 1 1.045 1 0.594 1 0.983 1 0.941 1 37 4.68 0 3 1203.2451 2.69 63.35 3623.68686

GLGEISAASEFK NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 2 5 115529482 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.53 1 1.268 1 0.547 1 0.431 1 0.655 1 0.516 1 1.198 1 35 3.54 0 2 618.3316 -5.14 12.44 1235.65593

GLGELQELYLK GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 8 1 291190772 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.151 1 0.054 1 0.952 1 17.575 1 1.316 1 24.304 1 1.383 1 7.12 0 5 774.58105 0.77 52.32 3868.87617

GLGVWFPGSATPPGLMVPR

GGN gametogenetin [Homo sapiens] 199720 NP_689870 1 1 33286436 N-Term(iTRAQ4plex); M16(Oxidation)

1.148 1 0.944 1 0.996 1 1.055 1 1.235 1 1.309 1 1.241 1 5.86 0 3 916.82861 -7.2 57.34 2748.47129

GLHLQALKPTKPGLLPSLFK SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 1 1 7705879 N-Term(iTRAQ4plex); K8(iTRAQ4plex); K11(iTRAQ4plex); K20(iTRAQ4plex)

1.57 1 0.87 1 1.424 1 1.637 1 1.512 1 1.739 1 1.062 1 31 1 3 553.34369 -9.67 67.26 1658.01651

GLIKDALENIDPATQMMILNCIYFK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 4 1 73858566 N-Term(iTRAQ4plex); K4(iTRAQ4plex); M16(Oxidation); C21(Methylthio); K25(iTRAQ4plex)

1.521 1 0.929 1 1.376 1 1.48 1 1.558 1 1.677 1 1.133 1 3.71 1 3 852.45154 19.5 43.82 2555.34006

GLIKDALENIDPATQMMILNCIYFK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 1 1 73858566 N-Term(iTRAQ4plex); K4(iTRAQ4plex); M16(Oxidation); M17(Oxidation); C21(Methylthio); K25(iTRAQ4plex)

1.533 3 25.8 0.796 3 17.5 1.317 3 12 1.958 3 9.4 1.269 3 17.4 2.046 3 7 1.028 3 2.3 4 0 4 881.67346 -0.76 48.43 3523.67202

GLKPGVVYEGQLISIQQYGHQEVTR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

20 5 47132549;16933542

N-Term(iTRAQ4plex); K3(iTRAQ4plex)

1.2 1 0.829 1 0.991 1 1.195 1 1.204 1 1.452 1 1.215 1 93 4.6 0 2 878.96881 -3.23 48.77 1756.93035

GLLIFDASSSWGPQMSASVHLDSK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); M15(Oxidation); K24(iTRAQ4plex)

1.453 3 3 0.974 3 6.3 1.407 3 6.5 1.347 3 0.8 1.521 3 4.7 1.48 3 4.3 1.081 3 1.8 77 4.36 0 2 697.90851 -2.6 41.24 1394.80974

GLLSGWAR PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 4 2 4506121 N-Term(iTRAQ4plex) 1.137 4 6.8 0.964 4 9.6 1.043 4 8.8 1.091 4 16.2 1.257 4 8.9 1.236 4 10 1.142 4 1.3 62 3.77 0 2 922.92078 -5.16 53.15 1844.83452

GLLVGEILSAVLSQEGINILTHLPK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 44 2 38016947 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.218 1 1.094 1 1.198 1 1.096 1 1.352 1 1.236 1 1.128 1 60 3.53 0 2 631.87573 4.82 20.3 1262.74419

GLMAALCPHK CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 2 1 4557417 N-Term(iTRAQ4plex); C7(Methylthio); K10(iTRAQ4plex)

1.289 1 1.222 1 1.462 1 1.197 1 1.402 1 1.147 1 0.959 1 54 6.94 0 3 706.02014 0.6 58.36 2116.04587

GLMAALCPHKFPAIQNLALR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 3 1 4557417 N-Term(iTRAQ4plex); C7(Methylthio); K10(iTRAQ4plex)

1.451 1 0.943 1 0.918 1 0.974 1 1.901 1 2.017 1 2.071 1 38 4.29 1 4 1045.7942 -0.76 76.93 4180.15493

GLNVTLSSTGR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex) 1.297 1 0.984 1 1.191 1 1.21 1 1.383 1 1.406 1 1.162 1 37 3.86 0 2 683.4043 0.13 55.94 1365.80132

GLPNVVTSAISLPNIR PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 4 4 189181722 N-Term(iTRAQ4plex) 1.161 1 0.778 1 0.89 1 1.145 1 1.173 1 1.508 1 1.317 1 3.49 1 3 717.04254 -1.03 27.49 2149.11307

GLPPLHIYWMNIELEHIEQDER

CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 N-Term(iTRAQ4plex) 1.764 2 3.5 0.934 2 14.9 1.64 2 8.2 1.756 2 6.7 1.775 2 13.1 1.9 2 1.8 1.082 2 4.9 29 2.97 1 2 626.30298 -19.65 29.56 1251.59868

GLPPVDFVPPIGVESR MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 2 1 24497519 N-Term(iTRAQ4plex) 0.919 2 16.2 0.956 2 21.3 0.841 2 28.8 0.88 2 7.1 0.961 2 25.3 1.006 2 3.8 1.143 2 3.3 48 4.02 0 2 640.37683 -2.86 41.67 1279.74907

GLQDEDGYR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

53 6 178557739;67190748

N-Term(iTRAQ4plex) 1.372 1 0.923 1 1.265 1 1.37 1 1.374 1 1.487 1 1.086 1 34 3.25 0 2 751.37579 1.97 25.2 1501.74431

GLQDVNLR DPEP2 dipeptidase 2 precursor [Homo sapiens]

64174 NP_071750 2 1 11641269 N-Term(iTRAQ4plex) 0.718 1 1.063 1 0.693 1 0.652 1 0.788 1 0.742 1 1.137 1 2.83 0 2 624.34454 8.47 29.12 1247.68181

GLQVALEEFHK RARRES2 retinoic acid receptor responder protein 2 precursor [Homo sapiens]

5919 NP_002880 2 1 4506427 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.953 1 1.027 1 2.028 1 1.975 1 1.93 1 1.88 1 0.952 1 3.88 2 4 744.12048 16.53 56.91 2973.4601

GLQYAAQEGLLALQSELLR LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 10 1 31652249 N-Term(iTRAQ4plex) 1.052 3 2.7 0.911 3 12.3 0.923 3 18.7 1.091 3 23.4 1.131 3 14.9 1.369 3 6.5 1.224 3 3.7 81 7.04 0 3 903.98737 -3.18 27.66 1806.97684

GLSTESILIPR LCN1 lipocalin-1 isoform 1 precursor [Homo sapiens]

3933 NP_002288 2 1 4504963 N-Term(iTRAQ4plex) 1.501 1 1.034 1 1.342 1 1.298 1 1.711 1 1.655 1 1.275 1 77 6.9 0 3 732.35919 -0.93 29.46 2195.06302

GLWEQCQLLK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 8 1 89191868 N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

1.39 8 34.7 1.079 8 38.4 1.377 8 46.7 1.172 8 20.3 1.748 8 50.9 1.493 8 38.4 1.165 8 16.3 77 7.72 0 3 1106.5353 3.37 66.38 3317.58432

GLYDVVSVLR ICOSLG ICOS ligand precursor [Homo sapiens]

23308 NP_056074 4 1 27477039 N-Term(iTRAQ4plex) 1.257 3 5.1 0.946 3 14.8 1.228 3 2.8 1.217 3 9.4 1.295 3 0.3 1.37 3 19.4 1.07 3 2.4 75 4.75 0 2 824.86456 0.12 50.65 1648.72185

GMADQDGLKPTIDKPSEDSPPLEMLGPR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 6 3 156119625 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K14(iTRAQ4plex)

1.184 3 7.9 0.98 3 6.1 1.103 3 1 1.125 3 7.1 1.188 3 19.2 1.263 3 15.2 1.176 3 8.2 72 8.14 0 3 732.35919 -0.93 29.46 2179.06125

GMADQDGLKPTIDKPSEDSPPLEMLGPR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 2 3 156119625 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K14(iTRAQ4plex); M24(Oxidation)

1.236 4 4.1 1.073 4 16.5 1.141 4 18 1.16 4 8.2 1.317 4 2.8 1.228 4 13.6 1.155 4 15.1 60 6.07 0 2 883.48193 -2.92 38.61 1765.95659

GMADQDGLKPTIDKPSEDSPPLEMLGPR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 1 3 156119625 N-Term(iTRAQ4plex); M2(Oxidation); K9(iTRAQ4plex); K14(iTRAQ4plex); M24(Oxidation)

1.327 3 4.1 1.043 3 2 1.265 3 2.2 1.208 3 1.6 1.428 3 9.6 1.367 3 2.1 1.129 3 0.4 59 3.95 0 2 714.34814 -0.82 29.38 1427.68901

GMALFGEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 13 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.177 3 3.3 0.85 3 11 1.035 3 13.4 1.081 3 0.1 1.207 3 5.1 1.372 3 5 1.227 3 21.5 55 3.45 0 2 1104.4852 1.1 31.01 2207.96318

GMALFGEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); M2(Oxidation); K9(iTRAQ4plex)

1.369 2 22.5 0.984 2 44 1.205 2 44.7 1.225 2 0.7 1.537 2 45.5 1.563 2 1.4 1.275 2 0.7 52 4.82 0 3 1288.6205 3.3 36.99 2576.23001

GMCTSPPLIK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 4 1 110611237 N-Term(iTRAQ4plex); C3(Methylthio); K10(iTRAQ4plex)

1.259 2 7.4 1.071 2 12.7 1.214 2 14.7 1.133 2 2 1.397 2 13.4 1.304 2 0.7 1.151 2 1.3 51 4.24 0 2 666.31232 -2.33 32.46 1331.61736

GMCTSPPLIK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 2 1 110611237 N-Term(iTRAQ4plex); M2(Oxidation); C3(Methylthio); K10(iTRAQ4plex)

1.058 3 17.9 1.008 3 1.7 0.916 3 11.2 1.08 3 1.9 1.038 3 19.1 1.224 3 5 1.133 3 3.1 45 3.41 0 2 580.82886 -3.47 23.48 1160.65398

GMDSCK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 4 1 41393602 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

1.197 2 4.9 0.986 2 15.1 1.09 2 2.8 1.106 2 17.9 1.289 2 7 1.307 2 8 1.182 2 9.8 45 5.16 0 3 506.62955 1.44 38.79 1517.87409

GMQDLVEDFK KRT6A keratin, type II cytoskeletal 6A [Homo sapiens]

3853 NP_005545 NP_490596

4 1 5031839 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.176 2 14.7 0.948 2 7.4 1.078 2 10.3 1.137 2 17.8 1.213 2 11.8 1.279 2 19.3 1.125 2 1.5 43 3.74 0 2 1227.5508 0.3 28.85 2454.09429

GMTNINDGLLR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 4 1 133925809 N-Term(iTRAQ4plex) 1.177 4 20.9 1.077 4 15 1.169 4 16.6 1.029 4 11 1.233 4 18.6 1.139 4 15.2 1.077 4 16.3 43 4.6 0 3 772.76587 3.95 76.17 2316.28434

GMTNINDGLLR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 3 1 133925809 N-Term(iTRAQ4plex); M2(Oxidation)

1.419 1 0.881 1 1.321 1 1.5 1 1.348 1 1.531 1 1.021 1 43 3.9 0 2 709.33002 1.43 33.9 1417.65276

GMTRPLSTLISSSQSCQYTLDAK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 26 1 105990532 N-Term(iTRAQ4plex); M2(Oxidation); C16(Methylthio); K23(iTRAQ4plex)

0.684 1 0.619 1 0.81 1 1.309 1 0.298 1 0.481 1 0.367 1 41 7.17 0 4 1007.4641 0.1 69.51 4026.83437

GMVLDENYNNLANAVISVSGINHDVTSGDHGDYFR

CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 7 1 4503011 N-Term(iTRAQ4plex) 1.261 1 1.111 1 1.296 1 1.167 1 1.364 1 1.228 1 1.052 1 39 4.01 0 2 666.87244 -1.25 47.46 1332.7376

GMVLDENYNNLANAVISVSGINHDVTSGDHGDYFR

CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 2 1 4503011 N-Term(iTRAQ4plex); M2(Oxidation)

1.104 2 0.8 0.963 2 1.9 1.026 2 3.8 1.065 2 1.9 1.14 2 3.2 1.184 2 5.1 1.112 2 7 36 6.37 0 3 1069.4345 -1.45 30.89 2137.86362

GNLCVNLMR C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 4 1 87298828 N-Term(iTRAQ4plex); C4(Methylthio)

1.282 1 0.845 1 1.062 1 1.256 1 1.303 1 1.541 1 1.227 1 35 3.86 0 2 636.28204 -4.83 24.65 1271.55681

GNLLQCICTGNGR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

9 6 47132549;16933542

N-Term(iTRAQ4plex); C6(Methylthio); C8(Methylthio)

1.032 1 1.002 1 0.986 1 0.985 1 1.08 1 1.078 1 1.095 1 34 0 2 401.27518 -0.74 12.14 801.54308

GNPAVSYVR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex) 1.043 3 11.9 1.003 3 3.1 0.982 3 16.2 0.971 3 1.9 1.129 3 5 1.165 3 5.8 1.15 3 11.1 33 3.33 0 2 565.72394 -0.01 46.06 1130.44048

GNPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLK

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 1 1 88853069 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K24(iTRAQ4plex); C49(Methylthio); K52(iTRAQ4plex); K61(iTRAQ4plex)

2.005 1 0.953 1 1.776 1 1.864 1 2.14 1 2.245 1 1.204 1 32 5.12 0 3 1069.4345 -1.45 30.89 2153.84085

GNSYFMVEVK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 6 1 21071039 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.225 2 8 0.951 2 20.4 1.137 2 21.8 1.196 2 1.3 1.258 2 14.5 1.323 2 5.8 1.106 2 7.1 32 3.11 0 2 519.2345 -0.76 10.16 1037.46306

GNTEGLQK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 16 1 71773110 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.146 1 1.049 1 1.064 1 1.015 1 1.283 1 1.223 1 1.206 1 31 3.09 0 2 638.30273 -0.06 52.65 1275.59819

GNVATEISTER APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 20 1 105990532 N-Term(iTRAQ4plex) 1.06 1 1.09 1 1.044 1 0.957 1 1.171 1 1.074 1 1.122 1 30 2.88 0 2 544.27832 -2.3 28.94 1087.54936

GNVVDWQNDFWNIPNLALK GPR126 G-protein coupled receptor 126 alpha 2 precursor [Homo sapiens]

57211 NP_001027566 2 4 74048422 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.977 2 4 0.963 2 7.3 0.889 2 10.5 0.923 2 3.2 1.029 2 5.1 1.069 2 2.2 1.158 2 5.4 26 4.96 0 3 742.01447 3.11 40.44 2224.01676

GPAAIQK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 4 2 55956899 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.161 2 5.4 1.028 2 8.4 1.112 2 10 1.082 2 1.7 1.243 2 9.3 1.209 2 0.9 1.118 2 0.7 25 0 2 535.24951 -0.93 40.78 1069.49211

GPDPSSPAFR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 4 1 40317626 N-Term(iTRAQ4plex) 1.293 2 5.4 1.12 2 16 1.375 2 1.1 1.227 2 14.9 1.369 2 4.9 1.222 2 11.1 0.996 2 3.8 8.67 0 5 711.14893 12.37 35.39 3551.71552

GPDVLTATVSGK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

66 2 31542984;262050538

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.313 1 0.902 1 1.081 1 1.199 1 1.416 1 1.57 1 1.309 1 5.11 1 4 476.77731 2.88 53.99 1904.08742

GPEEEHLGILGPVIWAEVGDTIR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 288 1 4557485 N-Term(iTRAQ4plex) 1.182 1 0.932 1 1.041 1 1.117 1 1.241 1 1.332 1 1.192 1 2.87 0 2 581.2854 -2.62 26.28 1161.56352

GPEVQLVAHSPWLK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

227 6 178557739;67190748

N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.179 13 7.7 1.031 13 13.3 1.145 13 10.9 1.072 13 10.7 1.302 13 11.5 1.252 13 10.8 1.138 13 4.9 113 6.81 0 2 886.4176 -9.37 23.79 1771.82793

GPGEDFR PTGDS prostaglandin-H2 D-isomerase precursor [Homo sapiens]

5730 NP_000945 2 1 32171249 N-Term(iTRAQ4plex) 1.312 4 8.1 0.993 4 9.7 1.209 4 19.5 1.317 4 13.4 1.45 4 21.4 1.562 4 15 1.211 4 1.5 106 5.78 0 3 886.4176 -9.37 23.79 1787.83792

GPILK RASGEF1A ras-GEF domain-containing family member 1A [Homo sapiens]

221002 NP_660356 1 4 117168263 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.184 4 14.3 1.028 4 3.5 1.012 4 26.4 0.966 4 23.4 1.46 4 9.2 1.401 4 11.9 1.397 4 13.2 100 8.75 0 3 929.1062 -10.83 30.12 2785.30405

GPLDQLEK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 10 1 73858566 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.177 49 13.1 0.971 49 12.4 1.081 49 16.3 1.191 49 14.9 1.191 49 16.4 1.316 49 18.1 1.139 49 9 96 6.87 0 2 944.53491 -2.38 68.56 1888.06255

GPLLNK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.071 6 9 0.949 6 3.3 0.977 6 12.1 0.976 6 10.5 1.098 6 14.2 1.127 6 9.4 1.119 6 6.1 90 6.03 0 2 866.45129 0.85 14.42 1731.89531

GPLQLER LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 2 1 16418467 N-Term(iTRAQ4plex) 1.624 3 5.5 0.836 3 1.7 1.353 3 9.7 1.618 3 8 1.63 3 3.5 1.949 3 1.9 1.256 3 6.2 86 8.39 0 3 929.1062 -10.83 30.12 2801.31662

GPMFELLPGESNK SRGN serglycin precursor [Homo sapiens] 5552 NP_002718 2 1 45935371 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.11 30 6.2 0.961 30 4.9 1.022 30 7.7 1.061 30 8.7 1.164 30 5.6 1.209 30 6.9 1.12 30 3.5 84 6.63 0 3 896.94446 0.39 61.67 1792.88164

GPMFELLPGESNK SRGN serglycin precursor [Homo sapiens] 5552 NP_002718 2 1 45935371 N-Term(iTRAQ4plex); M3(Oxidation); K13(iTRAQ4plex)

1.262 11 8.4 1.011 11 15.1 1.208 11 22.4 1.171 11 8.9 1.338 11 19.3 1.324 11 8.4 1.126 11 3.5 76 5.34 0 2 765.40375 4.22 22.76 1529.80022

GPSCQDCDTGYTR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 4 1 126012571 N-Term(iTRAQ4plex); C4(Methylthio); C7(Methylthio)

0.986 9 2.8 0.943 9 5.8 0.938 9 4 0.995 8 4.2 0.978 9 1.5 1.037 9 16.6 1.043 9 3.1 75 7.49 0 3 1111.9069 -0.73 46.34 3333.70498

GPSGLPGSPGPPGPPGIQGPAGLDGLDGK

COL16A1 collagen alpha-1(XVI) chain precursor [Homo sapiens]

1307 NP_001847 1 1 100913220 N-Term(iTRAQ4plex); K29(iTRAQ4plex)

1.725 2 6 0.959 2 0.2 1.61 2 2 1.679 2 2.2 1.767 2 9.5 1.843 2 9.7 1.097 2 7.5 74 4.51 0 3 866.45129 0.85 14.42 1747.88926

GPVLAWINAVSAFR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 8 1 21071039 N-Term(iTRAQ4plex) 1.519 2 0.7 0.965 2 0 1.392 2 1.3 1.442 2 1.3 1.593 2 0.1 1.651 2 0.1 1.145 2 1.1 73 4.72 0 2 896.94446 0.39 61.67 1808.87956

GPVSVGVDAR CTSS cathepsin S isoform 2 preproprotein [Homo sapiens]

1520 NP_001186668 2 2 315075311 N-Term(iTRAQ4plex) 1.058 12 22.3 0.965 12 14.6 0.96 12 43.4 1.093 12 15.4 1.111 12 35.3 1.339 12 9.1 1.102 12 8.9 64 4.1 0 2 687.43829 -4.82 45.38 1373.87639

GPWCFTTDPSVR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 1 1 4505881 N-Term(iTRAQ4plex); C4(Methylthio)

1.23 3 5.8 1.042 3 5.7 1.235 3 2.8 1.186 3 2.9 1.276 3 14.3 1.298 3 2.5 1.09 3 3.5 63 7.43 1 3 702.4281 0.11 40.03 2105.26975

GQCIINSNK AFM afamin precursor [Homo sapiens] 173 NP_001124 3 1 4501987 N-Term(iTRAQ4plex); C3(Methylthio); K9(iTRAQ4plex)

1.374 5 9.6 1.026 5 24.7 1.307 5 15 1.065 5 19.7 1.436 5 18.6 1.376 5 5.5 1.292 5 19.5 62 8.85 0 4 776.45874 0.54 71.06 3102.81508

GQCLITQSPPYYR HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 23 2 295054188 N-Term(iTRAQ4plex); C3(Methylthio)

1.239 12 8.7 1.02 12 15.6 1.193 12 20.1 1.161 12 4.3 1.351 12 15.3 1.324 12 7.6 1.118 12 6.3 62 2.87 0 2 674.89655 -0.71 46.22 1348.78581

GQDRWSQEDMLTLLECMK UBTF nucleolar transcription factor 1 isoform b [Homo sapiens]

7343 NP_001070151 1 2 115529451 N-Term(iTRAQ4plex); C16(Methylthio); K18(iTRAQ4plex)

1.161 5 15.4 1.066 5 22.8 1.146 5 25.8 1.077 5 2.5 1.253 5 30.6 1.262 5 2.5 1.172 5 6.3 58 4.39 0 2 774.90399 -2.74 29.45 1548.80071

GQELCADYSENTFTEYK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 372 2 32483410 N-Term(iTRAQ4plex); C5(Methylthio); K17(iTRAQ4plex)

1.157 7 13.8 1.129 7 8.4 1.059 7 24.7 1.013 7 9.5 1.285 7 37.1 1.146 7 9.2 1.133 7 10.1 56 9.06 0 4 776.45874 0.54 71.06 3086.81899

GQELCADYSENTFTEYKK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 4 2 32483410 N-Term(iTRAQ4plex); C5(Methylthio); K17(iTRAQ4plex); K18(iTRAQ4plex)

1.153 2 5.8 0.874 2 13.8 1.011 2 13.4 1.156 2 0.4 1.153 2 11.3 1.318 2 2.5 1.14 2 2.1 55 3.27 0 2 612.83575 -5.9 16.38 1224.66423

GQESSTDIK C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 8 1 289547636 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.516 2 6.5 0.98 2 1.7 1.411 2 12.3 1.439 2 10.6 1.59 2 2.9 1.622 2 1.2 1.127 2 9.4 51 5.16 0 3 611.69556 -0.2 66.37 1833.07212

GQGTLSVVTMYHAK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 5 1 115298678 N-Term(iTRAQ4plex); M10(Oxidation); K14(iTRAQ4plex)

1.544 1 1.155 1 1.646 1 1.425 1 1.681 1 1.455 1 1.021 1 48 4.55 0 3 886.4176 -9.37 23.79 1803.83237

GQGTLSVVTMYHAK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 10 1 115298678 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.146 14 13.2 1.043 14 16.3 1.14 14 19.1 1.082 14 7.1 1.277 14 17.5 1.22 14 6.9 1.124 14 4.8 42 3.08 0 2 533.35059 2.65 29.89 1065.68816

GQIHLDPQQDYQLLQVQR DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 6 1 116534900 N-Term(iTRAQ4plex) 1.187 2 20 0.954 2 5.3 1.06 2 19.9 1.111 2 14.4 1.258 2 25.2 1.319 2 19.6 1.187 2 5.1 41 7.03 1 3 972.49799 0.2 40.59 2915.4794

GQINDIFQK ANGPTL3 angiopoietin-related protein 3 precursor [Homo sapiens]

27329 NP_055310 2 1 7656888 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.136 16 5.7 0.953 16 5.5 1.053 16 3.6 1.1 16 4.5 1.186 16 5.6 1.248 16 6.4 1.141 16 4.8 40 3.98 0 2 633.37494 1.38 66.75 1265.7426

GQIVFMNR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

4 6 178557739;67190748

N-Term(iTRAQ4plex) 0.77 3 8.6 0.994 3 38.9 0.761 3 4.1 0.611 3 43.5 0.853 3 35.9 0.843 3 2.7 1.38 3 46.6 34 8.26 1 5 684.01434 2.22 66.61 3416.04261

GQIVFMNR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex); M6(Oxidation)

1.192 1 0.908 1 1.131 1 1.245 1 1.144 1 1.259 1 1.011 1 30 0 3 385.5759 -0.4 15.34 1154.71314

GQPSVLQVVNLPIVERPVCK

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 75 1 4503635 N-Term(iTRAQ4plex); C19(Methylthio); K20(iTRAQ4plex)

1.176 2 5.4 0.88 2 13.2 1.018 2 3 1.157 2 10.2 1.195 2 1.2 1.358 2 14.4 1.173 2 4.1 2.86 0 2 633.37494 1.38 66.75 1281.73918

GQQYQGR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 2 1 4503635 N-Term(iTRAQ4plex) 2.562 1 0.901 1 2.304 1 2.557 1 2.566 1 2.849 1 1.114 1 3.88 0 3 916.46698 -12.02 39.83 2747.38639

GQTLLAVAK LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 4 1 16418467 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.527 1 0.864 1 1.348 1 1.56 1 1.498 1 1.734 1 1.112 1 49 3.94 0 2 639.83685 0.47 16.3 1278.66643

GQVPENEANVVITTLK CDH1 cadherin-1 preproprotein [Homo sapiens]

999 NP_004351 2 1 4757960 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

36 2.89 0 2 691.33331 -6.62 37.5 1381.65935

GQVVPALNEK CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

4 1 256217721 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.122 2 2.9 1.099 2 2.5 1.085 2 7.2 0.987 2 4.7 1.271 2 1.8 1.156 2 0.8 1.171 2 5.4 59 4.23 0 2 652.39801 4.86 16.69 1303.78874

GQWGTVCDDGWDIK CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 4 1 5174411 N-Term(iTRAQ4plex); C7(Methylthio); K14(iTRAQ4plex)

0.959 1 0.893 1 0.854 1 0.957 1 0.961 1 1.077 1 1.125 1 53 4.53 0 2 721.40137 0.02 34.84 1441.79546

GQWVTK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 2 1 39725934 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.33 1 0.982 1 1.253 1 1.276 1 1.383 1 1.408 1 1.104 1 88 5.27 0 2 772.94257 0.87 66.72 1544.87786

GQYCYELDEK VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 131 1 88853069 N-Term(iTRAQ4plex); C4(Methylthio); K10(iTRAQ4plex)

1.106 1 0.827 1 0.948 1 1.146 1 1.072 1 1.297 1 1.131 1 82 4.22 0 2 800.97357 -0.12 48.91 1600.93987

Page 18: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

GRFPLYNLGFGHNVDFNFLEVMSMENNGR

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 8 3 156119625 N-Term(iTRAQ4plex); M24(Oxidation)

1.192 1 1.115 1 1.25 1 1.121 1 1.272 1 1.141 1 1.018 1 45 3.83 0 3 615.01996 -0.14 74.51 1843.04532

GRPGPQPWCATTPNFDQDQR

F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 5 1 145275213 N-Term(iTRAQ4plex); C9(Methylthio)

1.181 1 0.917 1 1.076 1 1.173 1 1.188 1 1.295 1 1.104 1 43 7.29 0 3 800.47229 -1.28 58.03 2399.40232

GSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); M8(Oxidation); K37(iTRAQ4plex)

1.308 1 0.704 1 1.011 1 1.436 1 1.217 1 1.728 1 1.203 1 4.6 0 3 860.79388 3.17 57.38 2580.3671

GSAPPGPVPEGSIR GSTO1 glutathione S-transferase omega-1 isoform 2 [Homo sapiens]

9446 NP_001177931 2 2 300360532 N-Term(iTRAQ4plex) 1.556 1 0.888 1 1.347 1 1.516 1 1.591 1 1.791 1 1.182 1 3.92 0 2 731.92548 -4.9 28.74 1462.84368

GSAVVGQYQSYSEQVR H6PD GDH/6PGL endoplasmic bifunctional protein precursor [Homo sapiens]

9563 NP_004276 2 1 52145310 N-Term(iTRAQ4plex) 1.232 1 0.963 1 1.127 1 1.171 1 1.29 1 1.34 1 1.145 1 3.08 0 2 886.37836 1.56 59.84 1771.74944

GSEAINAPGDNPAK C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 6 1 289547636 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.103 2 11.8 0.966 2 8.8 0.999 2 4.7 1.034 2 13.5 1.171 2 9.9 1.212 2 18.7 1.172 2 5.2 66 4.78 0 2 759.87921 -0.36 32.2 1518.75115

GSEMVVAGK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

23 2 31542984;262050538

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.061 1 0.944 1 0.994 1 1.053 1 1.068 1 1.131 1 1.075 1 58 4.47 0 2 822.83234 -2.02 21.35 1644.6574

GSEMVVAGK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

11 2 31542984;262050538

N-Term(iTRAQ4plex); M4(Oxidation); K9(iTRAQ4plex)

1.1 3 0.9 0.986 3 3.3 1.032 3 1.8 1.059 3 1.5 1.186 3 4.9 1.172 3 0.2 1.135 3 5.6 56 7.53 0 3 722.75531 -0.11 49.75 2166.24973

GSESGIFTNTK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.219 1 0.911 1 1.044 1 1.146 1 1.284 1 1.41 1 1.23 1 3.12 0 2 546.28552 0.14 32.45 1091.56377

GSFACQCPPGYQK EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C5(Methylthio); C7(Methylthio); K13(iTRAQ4plex)

1.357 43 8.6 0.932 43 11 1.22 43 13.1 1.307 43 7.1 1.379 43 12.8 1.486 43 8.2 1.139 43 5.8 100 5.86 0 2 776.93207 -0.33 30.22 1552.85686

GSFEFPVGDAVSK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

241 6 178557739;67190748

N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.408 188 9.8 0.947 188 16 1.297 188 16.5 1.353 188 13.8 1.454 188 13.6 1.539 188 14.3 1.129 189 12.3 92 9.73 0 3 1220.6433 -2.5 42.59 2440.28098

GSFPWQAK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 31 3 4826762 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.589 12 13.3 0.92 12 16.4 1.458 12 15.2 1.489 12 10.6 1.536 12 19.1 1.682 12 7.8 1.116 12 4.9 91 6.72 0 3 982.04773 1.54 23.02 1963.08818

GSFSTTVTGR LPA apolipoprotein(a) precursor [Homo sapiens]

4018 NP_005568 XP_931422 XP_946887

2 1 116292750 N-Term(iTRAQ4plex) 1.327 60 7.5 0.954 60 9.3 1.211 60 12.9 1.293 60 10.9 1.355 60 10.4 1.445 60 12.2 1.143 60 9.7 90 6.51 0 2 1005.0367 -0.94 57.51 2009.07134

GSGEADKDPSGSPASARK TULP1 tubby-related protein 1 [Homo sapiens]

7287 NP_003313 1 1 157266334 N-Term(iTRAQ4plex); K7(iTRAQ4plex); K18(iTRAQ4plex)

1.772 6 47.2 0.916 6 32.6 1.679 6 85.8 1.95 6 43.7 1.228 6 43.3 2.049 6 51.6 1.007 6 38.3 82 8.18 0 3 1378.9992 4.31 55.12 4134.98288

GSGTAEVELK PKM pyruvate kinase isozymes M1/M2 isoform e [Homo sapiens]

5315 NP_001193727 2 5 332164779 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.194 23 12.5 0.862 23 13.4 1.099 23 17 1.241 23 10.4 1.141 23 17.7 1.352 23 13.1 1.055 23 9.8 79 8.38 0 4 1141.058 -1.78 40.2 2281.10869

GSLGGGFSSGGFSGGSFSR

KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

6 2 195972866 N-Term(iTRAQ4plex) 1.264 65 12.7 0.984 65 16.2 1.16 65 17.2 1.157 65 13.7 1.353 65 15.4 1.372 65 15.6 1.14 65 12.5 77 7.58 0 3 1220.1919 2.12 73.34 2439.37651

GSLVQASEANLQAAQDFVR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 60 3 156119625 N-Term(iTRAQ4plex) 1.335 49 6.9 0.961 49 6.3 1.255 49 7.6 1.292 49 7.7 1.408 49 8.3 1.472 49 9 1.136 49 5.5 77 5.8 0 3 889.95361 3.44 82.03 1778.89995

GSMGTSGEACR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex); C10(Methylthio)

1.221 16 9.4 0.985 16 6.4 1.141 16 8.1 1.16 16 11.1 1.269 16 12.3 1.347 16 19.5 1.13 16 8.4 76 4.83 0 3 758.90533 2.96 16.63 1516.79697

GSPAINVAVHVFR TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 31 1 4507725 N-Term(iTRAQ4plex) 1.526 19 20.3 0.926 19 9.1 1.437 19 27.1 1.391 19 14.8 1.586 19 23.9 1.606 19 17.4 1.122 19 6.8 76 7.29 0 3 1220.1919 2.12 73.34 2455.36631

GSQAVSYTR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex) 1.296 50 9.1 0.975 50 9.5 1.173 50 13.9 1.25 50 9.4 1.372 50 11.5 1.426 50 10.6 1.123 50 4.8 68 4.6 0 2 616.84943 3.84 41.38 1232.68633

GSQTQSHPDLGTEGCWDQLSAPR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 34 1 156616294 N-Term(iTRAQ4plex); C15(Methylthio)

1.495 37 13.5 0.906 37 24.7 1.36 37 30.7 1.49 37 30.7 1.56 37 27 1.562 37 21.9 1.089 37 19.2 59 5.37 0 3 872.44067 2.92 65.24 2615.30143

GSQTVSYTR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex) 1.27 107 5.6 0.867 107 13.2 1.103 107 9.3 1.283 107 9.7 1.27 107 8.3 1.451 107 9.8 1.131 107 4.8 54 3.35 0 2 579.87128 1.39 75.57 1158.7321

GSSGGGCFGGSSGGYGGLGGFGGGSFR

KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

2 1 195972866 N-Term(iTRAQ4plex); C7(Methylthio)

1.318 39 6.9 0.978 39 13 1.223 39 10.6 1.253 39 11.3 1.411 39 7.8 1.398 39 6.9 1.131 39 6 46 5.32 0 3 934.53009 -5.06 19.83 1868.05021

GSSGLEEK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 6 1 169636415 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.271 12 10.5 0.951 12 11.3 1.156 12 15.1 1.281 12 9.1 1.317 12 15.6 1.447 12 4.7 1.126 12 3.3 45 3.17 0 2 560.28937 -5.09 37.59 1119.57781

GSSSGGGYSSGSSSYGSGGR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex) 1.334 49 5.6 0.952 49 8.3 1.203 49 8.6 1.259 49 8.2 1.394 49 9.1 1.454 49 5.9 1.14 49 7.2 43 3.11 0 2 475.30176 1.14 44.85 949.59685

GSSTWLTAFVLK C4B complement C4-B preproprotein [Homo sapiens]

721 NP_001002029 NP_000583 XP_001722858

20 2 178557739 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.986 13 50.4 0.943 12 16 0.774 13 29.1 0.995 12 46 1.111 12 183.8 1.129 11 42.7 1.084 12 58.7 34 7.53 0 7 1147.8342 -1.81 40.65 4588.31508

GSSVIHCDADSK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 6 1 4502503 N-Term(iTRAQ4plex); C7(Methylthio); K12(iTRAQ4plex)

1.128 4 33.8 1.05 4 16 1.035 4 21.8 0.94 4 7 1.272 4 42.2 1.212 4 121.2 1.229 4 91.2 7.13 0 7 1147.8342 -1.81 40.65 4604.32365

GSVQYLPDLDDK FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 6 1 58331240 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.326 8 16.2 1.055 8 10.2 1.241 8 16.8 1.061 8 19.6 1.547 8 17.3 1.386 8 22.1 1.182 8 15.1 95 8.09 0 3 827.7738 1.24 80.25 2481.30759

GSVSDEEMMELR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 1 1 167614506 N-Term(iTRAQ4plex); M8(Oxidation); M9(Oxidation)

1.246 5 22.1 0.969 5 15.7 1.11 5 21 1.317 5 18.8 1.132 5 8.2 1.527 5 12.3 1.137 5 2.9 94 5.49 0 2 764.44965 -4.26 28.05 1527.89165

GSVSDEEMMELR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 1 167614506 N-Term(iTRAQ4plex) 1.467 4 7.4 0.837 4 4.1 1.252 4 13.3 1.55 4 5.4 1.443 4 5.6 1.741 4 1.5 1.132 4 3.3 91 7.98 0 3 1153.5981 -0.76 42.01 2306.18662GSVSDEEMMELR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 1 1 167614506 N-Term(iTRAQ4plex);

M8(Oxidation)1.47 2 6.6 1.011 2 1.2 1.316 2 16.6 1.302 2 15.3 1.634 2 0.2 1.617 2 1.4 1.241 2 16.8 86 4.91 0 3 928.48706 -0.15 41.21 1855.96506

GSWFLTGVLGSQPVGGQAHMVLVTK

PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 8 2 4506121 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.397 3 12.2 0.932 3 36.6 1.306 3 31 1.361 3 0.8 1.393 3 31 1.494 3 5.1 1.067 3 0.1 85 10.54 0 3 1025.8826 2.63 59.83 3075.63315

GSWVNK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 3 1 73858566 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.565 2 1.2 0.965 2 11.3 1.453 2 8.4 1.507 2 2.9 1.623 2 5.2 1.682 2 6.1 1.116 2 3.2 85 7.35 0 3 1206.1458 -0.31 46.89 2411.28769

GTEAAAVPEVELSDQPENTFLHPIIQIDR

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 18 1 205277441 N-Term(iTRAQ4plex) 1.604 4 2.2 0.913 4 10.1 1.509 4 0.4 1.628 4 10.1 1.63 4 5.2 1.704 4 1.8 1.094 4 3.4 79 5.03 0 2 822.97015 -0.77 80.34 1644.93645

GTEAAGAMFLEAIPMSIPPEVK

SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 4 1 189163538 N-Term(iTRAQ4plex); M8(Oxidation); M15(Oxidation); K22(iTRAQ4plex)

1.784 2 0.2 1.282 2 11.4 1.962 2 6.5 1.53 2 4.9 2.112 2 5.8 1.647 2 5.6 1.077 2 0.7 78 5.33 0 3 1077.0536 -0.3 47.24 2153.09854

GTEAAGAMFLEAIPMSIPPEVK

SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 2 1 189163538 N-Term(iTRAQ4plex); M15(Oxidation); K22(iTRAQ4plex)

1.462 5 15.3 0.926 5 11.9 1.356 5 18.3 1.45 5 6.8 1.473 5 8.3 1.564 5 9.4 1.097 5 11.9 75 6.36 0 3 799.09235 -3.48 31.64 2395.26249

GTEAVAGILSEITAYSMPPVIK

SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 2 1 7705879 N-Term(iTRAQ4plex); M17(Oxidation); K22(iTRAQ4plex)

1.455 3 0.3 1.086 3 13.8 1.461 3 4.6 1.346 3 9.1 1.58 3 6.2 1.456 3 7.5 1.093 3 1.6 73 5.29 0 2 731.38568 -0.66 26.67 1461.75969

GTELQHLLHAVVPGPWQEDVADAEECAGR

MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 16 1 205277383 N-Term(iTRAQ4plex); C26(Methylthio)

1.498 3 12.7 0.933 3 10.7 1.346 3 21 1.496 3 5.3 1.549 3 28.8 1.66 3 2.1 1.151 3 0.1 59 4.15 0 2 675.85419 1.49 35.77 1350.7011

GTFSTTVTGR LPA apolipoprotein(a) precursor [Homo sapiens]

4018 NP_005568 XP_931422 XP_946887

2 1 116292750 N-Term(iTRAQ4plex) 1.31 2 23.7 0.994 2 16 1.234 2 15.5 1.241 2 32.1 1.382 2 15.6 1.391 2 32.2 1.12 2 0 56 4.42 0 2 705.36597 2.18 36.64 1409.72466

GTGENYR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 3 1 4505881 N-Term(iTRAQ4plex) 1.3 4 10.1 0.915 4 8.3 1.179 4 3.1 1.299 4 10 1.3 4 10.2 1.421 4 17.2 1.094 4 7.1 52 6.47 0 3 656.64575 0.11 31.89 1967.91831

GTHCNQVEVIATLK PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 22 1 4505981 N-Term(iTRAQ4plex); C4(Methylthio); K14(iTRAQ4plex)

1.247 2 2.5 1.029 2 2.8 1.181 2 10.2 1.148 2 13 1.345 2 7 1.307 2 4.2 1.139 2 17.3 49 4.08 0 3 457.58438 1.04 33.84 1370.7363

GTHVDLGLASANVDFAFSLYK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 150 1 50659080 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.345 1 1.021 1 1.321 1 1.294 1 1.398 1 1.369 1 1.058 1 47 3.62 0 3 468.25717 8.72 22.14 1402.75696

GTLLALER THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 3 1 40317626 N-Term(iTRAQ4plex) 0.978 3 2.4 1.109 3 22.1 1.039 3 36.7 1.001 3 32.4 1.158 3 28.6 1.173 3 40.7 1.162 3 1.3 44 3.2 0 2 649.85602 4.95 19.8 1298.67986

GTLTEGGTQK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.885 2 46.3 0.785 2 125.3 1.421 2 117.8 1.809 2 3.9 2.123 2 99.4 2.703 2 14.4 1.494 2 10.4 4.01 0 4 915.24786 1.17 63.47 3657.96963

GTMATTVGGLPCQAWSHK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); M3(Oxidation); C12(Methylthio); K18(iTRAQ4plex)

1.471 1 0.891 1 1.328 1 1.492 1 1.453 1 1.632 1 1.094 1 3.53 0 3 432.26147 -1.77 13.4 1294.76987

GTMATTVGGLPCQAWSHK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 6 1 205277383 N-Term(iTRAQ4plex); C12(Methylthio); K18(iTRAQ4plex)

1.318 1 1.089 1 1.334 1 1.225 1 1.42 1 1.304 1 1.065 1 3.78 0 3 756.75323 0.03 72.8 2268.24515

GTNYLADVFEK S100A7 protein S100-A7 [Homo sapiens] 6278 NP_002954 2 1 115298657 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.737 3 6.7 1.051 3 2 0.7 3 4.2 0.666 3 2.2 0.811 3 10.9 0.772 3 8.9 1.159 3 6.7 81 5.08 0 3 887.95007 -0.64 18.64 1774.89237

GTSGPPLTMATVSLETSK SPN leukosialin precursor [Homo sapiens]

6693 NP_003114 1 1 4507181 N-Term(iTRAQ4plex); M9(Oxidation); K18(iTRAQ4plex)

0.986 1 0.866 1 0.891 1 1.03 1 0.948 1 1.095 1 1.064 1 42 3.01 0 2 697.40857 4.07 24.46 1393.80986

GTSHEAGIVCR CETP cholesteryl ester transfer protein precursor [Homo sapiens]

1071 NP_000069 2 1 169636439 N-Term(iTRAQ4plex); C10(Methylthio)

1.546 3 10.9 0.924 3 5.2 1.359 3 12.7 1.525 3 0.4 1.565 3 19.9 1.755 3 8 1.212 3 7.1 115 5.9 0 2 877.39063 -2.8 23.31 1753.77397

GTSQNDPNWVVR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 4 1 40317626 N-Term(iTRAQ4plex) 1.528 2 4.7 0.989 2 4.4 1.391 2 7.3 1.407 2 2.9 1.648 2 6.6 1.667 2 2.2 1.185 2 0.7 82 4.31 0 2 756.39209 -4.17 28.25 1511.7758

GTSSTTTTGK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 42 1 4505881 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.167 5 17.2 1.046 5 13.6 1.287 5 15.6 1.171 5 9.3 1.168 5 11.5 1.349 5 33.4 1.086 5 8.7 69 4.72 0 2 854.4516 2.95 68.29 1707.89592

GTVCFYGHLDVQPADR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 6 1 21071039 N-Term(iTRAQ4plex); C4(Methylthio)

1.247 7 10 0.747 7 6.6 1.034 7 20.8 1.324 7 18.1 1.197 7 12.6 1.565 7 18.1 1.133 7 15 68 8.93 0 3 888.78308 0.77 58.59 2664.33469

GTVIDVTDFVNWASSINDAPVLISQK

C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 85 1 4502511 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.774 1 1.007 1 1.585 1 1.574 1 1.976 1 1.962 1 1.246 1 62 6.5 0 3 888.78308 0.77 58.59 2680.33152

GTVYNYR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 6 2 38016947 N-Term(iTRAQ4plex) 1.341 1 0.947 1 1.284 1 1.356 1 1.326 1 1.401 1 1.033 1 3.97 0 3 515.27063 1.19 10.94 1543.79734

GTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVK

CALR calreticulin precursor [Homo sapiens]

811 NP_004334 2 1 4757900 N-Term(iTRAQ4plex); K36(iTRAQ4plex)

0.761 2 20.7 1.089 2 2.8 0.742 2 16.9 0.681 2 19.8 0.849 2 21.2 0.779 2 24.2 1.143 2 4.2 69 4.84 0 2 727.4248 -5.6 40.48 1453.84233

GTWTQPFDLASTR SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 11 1 73858564 N-Term(iTRAQ4plex) 0.716 2 56.9 0.889 2 6.5 0.603 2 64.8 0.678 2 73.5 0.749 2 44.5 0.842 2 52.1 1.242 2 16.8 62 5.42 0 4 841.45227 -10.11 19.34 1681.89785

GTYGLSCQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); C7(Methylthio)

0.67 2 17.1 0.987 2 0 0.591 2 12.7 0.599 2 12.7 0.739 2 20.7 0.749 2 20.7 1.251 2 7.8 60 4.37 0 3 862.39349 2.33 48.74 1723.77976

GTYIPVPIVSELQSGK F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 4 1 119395709 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.985 1 1.03 1 0.937 1 0.91 1 1.063 1 1.032 1 1.134 1 50 2.96 0 2 624.37469 -2.28 16.02 1247.74211

GTYSTTVTGR LPA apolipoprotein(a) precursor [Homo sapiens]

4018 NP_005568 XP_931422 XP_946887

6 1 116292750 N-Term(iTRAQ4plex) 1.148 2 2.3 0.962 2 13.2 1.023 2 11.8 1.063 2 1.4 1.229 2 2.1 1.277 2 15.4 1.201 2 14 49 5.91 0 3 751.37463 0.46 64.58 2252.10953

GVASLFAGR CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 2 2 330688397 N-Term(iTRAQ4plex) 1.003 1 0.944 1 0.982 1 1.04 1 0.969 1 1.026 1 0.987 1 9.25 0 5 901.27618 2.15 57.25 4502.35181

GVCEETSGAYEK AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 32 1 4502067 N-Term(iTRAQ4plex); C3(Methylthio); K12(iTRAQ4plex)

85 5.85 0 3 886.47369 -3.31 33.53 1771.93595

GVFFSVNSWTPDSMSFIYK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 4 1 29171717 N-Term(iTRAQ4plex); M14(Oxidation); K19(iTRAQ4plex)

102 4.64 0 2 831.40613 -4.07 26.57 1661.80498

GVFFSVNSWTPDSMSFIYK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 2 1 29171717 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

86 6.24 0 2 879.42108 1.67 48.4 1757.83489

GVFVLNK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

66 5.62 0 3 1009.976 -1.48 61.58 2018.94449

GVGAAATAVTQALNELLQHVK

TLN1 talin-1 [Homo sapiens] 7094 NP_006280 6 1 223029410 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

63 4.75 0 2 961.02051 1.43 44.56 1921.02861

GVGGAPPTVTLLR LRP1 prolow-density lipoprotein receptor-related protein 1 precursor [Homo sapiens]

4035 NP_002323 2 1 126012562 N-Term(iTRAQ4plex) 61 3.69 0 2 642.33893 -1.94 34.08 1283.6685

GVGGGIPPITTR PLXNB1 plexin-B1 precursor [Homo sapiens] 5364 NP_001123554 2 1 194272180 N-Term(iTRAQ4plex) 56 6.05 0 3 761.34149 -3.14 42.94 2282.00992

GVGGSQPPDIDKTELVEPTEYLVVHLK

ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 1 1 157266300 N-Term(iTRAQ4plex); K12(iTRAQ4plex); K27(iTRAQ4plex)

40 3.14 0 2 548.28583 -2.68 12.17 1095.56438

GVGWSHPLPQCEIVK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 28 1 4502503 N-Term(iTRAQ4plex); C11(Methylthio); K15(iTRAQ4plex)

39 4.29 0 3 661.00336 4.07 21.79 1980.99552

GVISIPR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex) 39 0 2 530.81561 -0.15 11.12 1060.62395

GVNLQEFLNVTSVHLFK F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 2 1 119395709 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

34 3.15 0 2 751.34985 1.87 44.98 1501.69243

GVNTDSGSVCR PEPD xaa-Pro dipeptidase isoform 1 [Homo sapiens]

5184 NP_000276 NP_116041

2 3 149589008 N-Term(iTRAQ4plex); C10(Methylthio)

6.63 1 4 642.54449 -1.82 34.25 2567.15615

GVNVCQETCTK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 17 1 78191798 N-Term(iTRAQ4plex); C5(Methylthio); C9(Methylthio); K11(iTRAQ4plex)

1.278 2 2 0.849 2 10.7 1.139 2 9.5 1.342 2 1.2 1.224 2 4.5 1.442 2 6.2 1.075 2 5 87 5.32 0 2 947.95721 1.01 22.9 1894.90715

GVPIPNK A2M;PZP alpha-2-macroglobulin precursor [Homo sapiens];pregnancy zone protein precursor [Homo sapiens]

2;5858 NP_000005;NP_002855

1 2 66932947;162809334

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.321 2 3 0.925 2 11.7 1.199 2 7.2 1.297 2 4.5 1.344 2 9.9 1.454 2 1.8 1.121 2 2.7 85 5.39 0 2 906.93341 0.36 45.4 1812.85954

GVQVETISPGDGR FKBP1A peptidyl-prolyl cis-trans isomerase FKBP1A isoform b [Homo sapiens]

2280 NP_001186715 1 2 315139020 N-Term(iTRAQ4plex) 1.229 1 1.031 1 1.181 1 1.146 1 1.314 1 1.275 1 1.112 1 41 3 0 2 653.35663 -0.95 24.53 1305.70598

GVSLFDIINPEIITR CETP cholesteryl ester transfer protein precursor [Homo sapiens]

1071 NP_000069 4 1 169636439 N-Term(iTRAQ4plex) 1.203 2 15.6 1.055 2 3.8 1.163 2 21.8 1.102 2 17.9 1.308 2 13.8 1.24 2 10 1.125 2 7.8 75 5.54 0 3 536.31787 -0.44 29.55 1606.93906

GVSVGPILSSSASDIFCDNENGPNFLFHNR

CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 8 2 330688397 N-Term(iTRAQ4plex); C17(Methylthio)

1.154 1 1.009 1 1.082 1 1.072 1 1.238 1 1.226 1 1.144 1 40 2.82 0 2 654.80554 -6.53 16.86 1308.60381

GVTFLLR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 76 1 21071030 N-Term(iTRAQ4plex) 1.072 1 0.879 1 0.942 1 1.071 1 1.073 1 1.22 1 1.139 1 38 3.52 0 2 660.33844 -1.25 39.76 1319.6696

GVTSVSQIFHSPDLAIR SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 73 1 73858568 N-Term(iTRAQ4plex) 1.169 1 0.943 1 1.044 1 1.108 1 1.226 1 1.3 1 1.174 1 37 3.39 0 2 567.80579 1.64 30.98 1134.6043

GVVDSEDIPLNLSR TRAP1 heat shock protein 75 kDa, mitochondrial precursor [Homo sapiens]

10131 NP_057376 1 1 155722983 N-Term(iTRAQ4plex) 1.105 1 1.029 1 1.056 1 1.026 1 1.187 1 1.153 1 1.124 1 31 3.46 0 2 623.30011 1.48 35.46 1245.59294

GVWGSVCDDNWGEKEDQVVCK

CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 2 1 5174411 N-Term(iTRAQ4plex); C7(Methylthio); K14(iTRAQ4plex); C20(Methylthio); K21(iTRAQ4plex)

1.344 1 0.913 1 1.284 1 1.406 1 1.288 1 1.411 1 1.003 1 33 0 2 459.81613 2.55 20.75 918.62499

GVYSSDVFDIFPGTYQTLEMFPR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 206 1 4557485 N-Term(iTRAQ4plex) 1.175 6 17.9 0.893 6 5.8 0.999 6 20 1.136 6 17.2 1.194 6 21.8 1.354 6 14.2 1.195 6 6.8 139 7.99 0 3 1170.6127 0.29 40.65 2340.20908

GVYSSDVFDIFPGTYQTLEMFPR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 45 1 4557485 N-Term(iTRAQ4plex); M20(Oxidation)

0.786 14 12.2 0.961 14 14.7 0.73 14 17.1 0.741 14 14.3 0.859 14 18.2 0.829 14 16.7 1.065 14 15.3 100 10.54 0 3 945.13507 -1.77 80.86 2833.39066

GWSEEELQGVLR DPEP2 dipeptidase 2 precursor [Homo sapiens]

64174 NP_071750 2 1 11641269 N-Term(iTRAQ4plex) 1.283 17 11.3 1.046 17 22.8 1.219 17 14 1.237 17 21.2 1.245 17 17.6 1.353 17 20.8 1.073 17 26.3 100 9.21 0 3 945.13507 -1.77 80.86 2849.38822

GWSPTPR CFHR3 complement factor H-related protein 3 isoform 2 precursor [Homo sapiens]

10878 NP_001160096 1 2 262231791 N-Term(iTRAQ4plex) 1.056 13 11.9 0.988 13 17.2 0.92 13 29.2 1.04 13 6 1.045 13 16.3 1.149 13 14.9 1.144 13 13.2 93 10.53 0 3 1382.2437 3.31 44.95 2763.48062

GWSTPPICSFTK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 4 1 13540563 N-Term(iTRAQ4plex); C8(Methylthio); K12(iTRAQ4plex)

1.04 8 14.7 0.952 8 7.1 0.939 8 7.9 0.993 8 19.2 1.032 8 2.6 1.145 8 15.2 1.104 8 7.8 89 6.64 0 2 920.0108 0.55 66.89 1839.01274

GWSTPPK CFHR1;CFHR2

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 2 precursor [Homo sapiens]

3078;3080 NP_002104;NP_005657

2 2 118442839;5031695

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.903 4 9.2 1.062 4 10.8 0.859 4 8.9 0.814 4 18.8 1.034 4 6.5 0.986 4 15.2 1.193 4 3.7 82 6.22 0 2 787.46307 -7.37 24.07 1573.91887

GWVDLFVPK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 18 1 205277441 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.264 8 26 0.912 8 5.7 1.052 8 23.4 1.187 8 20.7 1.23 8 29.1 1.558 8 31.6 1.226 8 12.4 77 7.64 0 3 1142.6365 9.85 31.05 2284.2634

GWVTDGFSSLK APOC3 apolipoprotein C-III precursor [Homo sapiens]

345 NP_000031 19 1 4557323 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.691 6 17.1 0.952 6 8.9 0.664 6 13.6 0.668 6 11.4 0.712 6 20.1 0.72 6 14.4 1.092 6 5.7 64 4.94 0 3 867.45404 4.21 33.58 1733.9

GWVTDGFSSLKDYWSTVK APOC3 apolipoprotein C-III precursor [Homo sapiens]

345 NP_000031 3 1 4557323 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K18(iTRAQ4plex)

0.951 9 24 0.911 9 27.8 0.973 9 21.9 0.884 9 19.5 1.05 9 24.8 1.061 9 19.4 1.135 9 8.5 62 4.51 0 3 559.64258 -0.37 52.18 1676.91318

GYAIGYGIGSPHAQTIK NEO1 neogenin isoform 2 precursor [Homo sapiens]

4756 NP_001166094 2 3 290656011 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.084 6 8.3 0.96 6 9.5 1.025 6 6 1.068 6 6.5 1.12 6 6.3 1.206 6 8.6 1.118 6 5.4 62 4.34 0 3 501.58145 3.6 32.33 1502.72173

GYAWGLNELKPISK MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 1 1 24497519 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K14(iTRAQ4plex)

1.365 4 3.9 0.977 4 17.4 1.28 4 11.1 1.287 4 3.7 1.419 4 10.8 1.443 4 5.7 1.121 4 2 57 3.75 0 2 652.40479 -4.04 40.84 1303.80229

GYGFYTK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

2 1 66347875 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.948 4 4.6 0.95 4 7.5 0.861 4 7.2 0.94 4 5.6 0.965 4 5.2 1.078 4 14.1 1.146 4 8.5 55 6.58 0 3 793.71924 7.89 26.29 2379.14316

GYGNSDYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 15 2 38016947 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.71 5 3.7 0.987 5 6 1.572 5 2 1.632 5 7.6 1.788 5 3.9 1.87 5 8.6 1.139 5 2.2 55 4.7 0 3 867.45404 4.21 33.58 1749.89737

GYHLNEEGTR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

4 4 34734066;34734062

N-Term(iTRAQ4plex) 1.286 1 1.027 1 1.219 1 1.187 1 1.387 1 1.35 1 1.137 1 54 4.29 1 2 788.50433 -2.04 32.8 1576.00139

GYILVGQAK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 1 1 4502503 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.996 5 7.1 1.026 5 9.9 0.957 5 19 0.94 5 2.4 1.105 5 6.6 1.078 5 3.7 1.139 5 5.7 53 4.12 0 3 446.24155 -2.23 42.38 1336.71196

GYPKLLQDEFPGIPSPLDAAVECHR

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 2 1 11321561 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C23(Methylthio)

0.991 13 16.8 1.025 13 13.2 0.944 13 21.8 0.918 13 12.9 1.067 13 19.3 1.066 13 11.5 1.132 13 6.7 53 3.7 0 2 639.87164 4.98 30.33 1278.72832

GYQELLEK AFP alpha-fetoprotein precursor [Homo sapiens]

174 NP_001125 3 1 4501989 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.075 12 15.1 1.077 12 13.3 1.041 12 18.3 0.999 12 10.6 1.204 12 18.3 1.112 12 10.7 1.128 12 3.3 52 4.11 0 2 658.37958 1.39 42.06 1315.74944

GYQINWWK CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.229 6 15.3 1.017 6 17.5 1.242 6 28.9 1.195 6 16.3 1.394 6 26.2 1.468 6 12.9 1.15 6 2.6 48 4.41 0 2 898.00122 -2.31 38.38 1794.99285

GYQLSDVDGVTCEDIDECALPTGGHICSYR

FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

8 4 34734066;34734062

N-Term(iTRAQ4plex); C12(Methylthio); C18(Methylthio); C27(Methylthio)

2.078 1 0.846 1 1.752 1 2.069 1 2.085 1 2.463 1 1.19 1 46 2.98 0 2 867.45404 4.21 33.58 1765.89031

GYSFTTTAER ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 4 2 4501885 N-Term(iTRAQ4plex) 1.168 1 0.441 1 0.764 1 1.733 1 0.919 1 2.085 1 1.203 1 46 5.76 1 4 823.67377 -0.14 78.31 3291.67324

GYTQQLAFR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 30 1 115298678 N-Term(iTRAQ4plex) 1.038 2 2.2 0.908 2 1.9 0.93 2 5.8 1.025 2 3.9 1.049 2 0.6 1.156 2 1.3 1.127 2 5.2 45 3.98 0 2 811.47089 2.47 27.23 1621.9345

GYVIIKPLVWV APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 49 1 4502133 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.229 4 5.6 1.025 4 10.1 1.186 4 7.1 1.193 4 11.8 1.291 4 11.5 1.272 4 5.1 1.117 4 8.2 45 5.38 0 4 793.71924 7.89 26.29 2395.14052

HADPDFTR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 14 1 70778918 N-Term(iTRAQ4plex) 1.003 2 5.2 1.046 2 4.9 0.962 2 13.9 0.92 2 9 1.088 2 2.2 1.04 2 2.7 1.131 2 11.8 36 2.96 0 2 557.79138 -0.64 17.82 1114.58806

HAIILLTDGK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 4 3 14550407 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.951 3 1.8 0.928 3 7 0.867 3 11.8 0.896 3 2.8 0.966 3 9.7 1.022 3 2.7 1.12 3 0.8 33 0 2 570.80457 -0.67 34.03 1140.60185

HCLVTVEK PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 2 1 192447438 N-Term(iTRAQ4plex); C2(Methylthio); K8(iTRAQ4plex)

1.055 2 17.8 0.995 2 16 0.973 2 25.1 0.978 2 8.9 1.133 2 26.8 1.139 2 10.5 1.165 2 1.6 2.97 0 2 522.32019 -0.81 14.11 1043.6331

Page 19: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

HDGIPAECTTIYNR ANGPTL3 angiopoietin-related protein 3 precursor [Homo sapiens]

27329 NP_055310 2 1 7656888 N-Term(iTRAQ4plex); C8(Methylthio)

1.046 1 0.956 1 0.943 1 0.986 1 1.103 1 1.154 1 1.17 1 64 4.36 0 2 824.43213 -3.12 41.64 1647.85698

HELTDEELQSLFTNFANVVDK

AFM afamin precursor [Homo sapiens] 173 NP_001124 28 1 4501987 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

0.995 1 0.928 1 0.952 1 1.025 1 0.968 1 1.042 1 1.017 1 3.04 0 2 658.8244 -0.81 23.81 1316.64153

HEQDMVNGIMLSVEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); M10(Oxidation); K15(iTRAQ4plex)

1.254 1 0.759 1 1.008 1 1.329 1 1.197 1 1.578 1 1.188 1 2.79 0 2 663.35052 -19.13 12.14 1325.69377

HETEIMPVFQGLNELIPMYK ERAP1 endoplasmic reticulum aminopeptidase 1 isoform b precursor [Homo sapiens]

51752 NP_001035548 2 2 94818891 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.074 6 4.4 1.076 6 12.1 1.057 6 12.5 0.995 6 5 1.159 6 9.2 1.068 6 5.7 1.09 6 2.9 112 6 0 2 944.48456 -3.85 23.15 1887.96184

HFQNLGK AFM afamin precursor [Homo sapiens] 173 NP_001124 3 1 4501987 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.919 3 3.3 0.999 3 12.5 0.893 3 7.9 0.866 3 11.5 0.935 3 6.3 0.936 3 6.1 1.037 3 17.7 96 10.01 0 3 974.35846 -0.09 51.48 2921.06614

HGAGVAMDGQDVQLPLLK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.106 1 0.928 1 1.014 1 1.092 1 1.119 1 1.206 1 1.104 1 94 5.99 0 2 1023.5064 0.24 32.08 2046.00542

HGGGGGGFGGGGFGSR KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 3 2 47132620 N-Term(iTRAQ4plex) 1.063 6 16.9 0.996 6 16.6 0.983 6 12.6 1.021 6 11.8 1.132 6 14.1 1.19 6 19.2 1.152 6 5.6 91 5.45 0 2 900.97754 1.85 61.79 1800.9478

HGNTDSEGIVEVK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 4 1 119392081 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.906 2 25.6 1.113 2 9.5 0.945 2 20.2 0.849 2 10.6 0.966 2 41.9 0.868 2 31.5 1.023 2 20.4 86 6.26 0 3 989.10712 -0.39 70.05 2965.3068

HGPSSSVGTVIGTGTGGLVEAGGQPQPR

KLHDC7B kelch domain-containing protein 7B [Homo sapiens]

113730 NP_612442 1 1 206597556 N-Term(iTRAQ4plex) 1.01 3 2 0.991 3 2.9 0.876 3 3 0.987 3 2.1 1.017 3 2 1.07 3 11 1.161 3 1 85 5.01 0 2 893.3692 0.75 48.69 1785.73113

HGVQELEIELQSQLSK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.976 1 0.902 1 0.926 1 1.026 1 0.93 1 1.031 1 1.004 1 84 4.42 0 2 849.9917 1.17 19.94 1698.97612

HIIVACEGSPYVPVHFDASVEDST

RNASE1 ribonuclease pancreatic precursor [Homo sapiens]

6035 NP_002924 2 1 4506547 N-Term(iTRAQ4plex); C6(Methylthio)

0.856 10 4.3 0.975 10 35.2 0.819 10 20.1 0.834 10 11.7 0.923 10 18.4 0.909 10 14.5 1.114 10 11.8 76 8.31 0 3 1046.4973 -0.08 78.35 3137.47739

HINIDQFVR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex) 1.262 5 3.7 1.02 5 3.9 1.236 5 0.2 1.178 5 4.2 1.338 5 3.4 1.286 5 2.3 1.089 5 2.7 66 4.82 0 2 721.38043 -4.43 32.11 1441.75359

HIQNIDIQHLAGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.026 6 12.5 0.971 6 4.3 0.952 6 12.2 0.98 6 13.3 1.077 6 13.2 1.107 6 8.5 1.139 6 4.3 66 5.67 0 2 815.823 -3.89 29.54 1630.64751

HIVTFDGQNFK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.885 3 11 0.89 3 41 0.783 3 31.1 0.88 3 4.6 0.889 3 29.1 0.999 3 7.6 1.135 3 1.8 57 4.29 0 2 741.3255 -1.92 26.23 1481.64836

HIYAISSAALSASYK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 41 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.011 3 1 0.895 3 31.9 0.886 3 20.3 0.99 3 11.1 1.017 3 15.9 1.141 3 0.6 1.209 3 4 56 4.98 0 2 703.35645 0.51 35.04 1405.70098

HLEVDVWVIEPQGLR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 52 1 70778918 N-Term(iTRAQ4plex) 1.58 4 7.2 0.908 4 16.3 1.434 4 11.5 1.44 4 6.4 1.679 4 6.6 1.612 4 7.1 1.149 4 2.9 55 4.05 0 3 715.86438 -0.5 11.07 1430.72293

HLIATQLLSNLEDIMR CD97 CD97 antigen isoform 2 preproprotein [Homo sapiens]

976 NP_001775 2 3 17978489 N-Term(iTRAQ4plex) 0.994 1 1.062 1 0.948 1 0.892 1 1.103 1 1.039 1 1.165 1 54 0 2 560.31055 2.44 19.32 1119.61382

HLIDSLIDFLNFPR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 19 1 105990532 N-Term(iTRAQ4plex) 0.984 3 1.4 1.112 3 24.1 0.898 3 3.7 0.882 3 30.3 1.097 3 15.7 0.987 3 8.2 1.118 3 8.4 49 5.74 0 4 1127.42 -9.75 32.79 2253.83388

HLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 20 1 115298678 N-Term(iTRAQ4plex); C9(Methylthio); M14(Oxidation); K35(iTRAQ4plex)

1.446 1 1.03 1 1.351 1 1.312 1 1.585 1 1.539 1 1.173 1 49 0 2 741.3255 -1.92 26.23 1497.64629

HLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 50 1 115298678 N-Term(iTRAQ4plex); C9(Methylthio); K35(iTRAQ4plex)

1.314 4 7 1.061 4 2.7 1.284 4 5.6 1.189 4 8.3 1.448 4 7.7 1.341 4 8.2 1.176 4 1.2 49 2.96 0 2 557.78491 0.58 10.58 1114.56255

HLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex); C9(Methylthio); M14(Oxidation); M17(Oxidation); K35(iTRAQ4plex)

0.812 1 0.724 1 0.63 1 0.869 1 0.77 1 1.063 1 1.223 1 48 3.43 0 2 650.40082 2.91 54.31 1299.79436

HLLGPDYTETLYSPR ADAMDEC1 ADAM DEC1 isoform 2 [Homo sapiens]

27299 NP_001138743 2 2 223671930 N-Term(iTRAQ4plex) 1.157 1 0.976 1 1.088 1 1.116 1 1.198 1 1.228 1 1.101 1 47 0 2 495.27374 1.81 14.37 989.54021

HLSLLTTLSNR GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 22 2 32483410 N-Term(iTRAQ4plex) 1.033 4 16.1 0.948 4 4.8 0.957 4 9.4 1.03 4 14.2 1.037 4 14.4 1.117 4 22.3 1.116 4 6.8 44 4.23 0 3 753.86816 -1.58 48.96 1506.73185

HLVALSPK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 3 1 73858564 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.683 1 0.949 1 0.632 1 0.667 1 0.699 1 0.736 1 1.105 1 37 0 2 511.82993 3.63 21.78 1022.65257

HLVCNGDQDCLDGSDEDDCEDVR

C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 10 1 4557389 N-Term(iTRAQ4plex); C4(Methylthio); C10(Methylthio); C19(Methylthio)

1.164 1 1.026 1 1.107 1 1.079 1 1.251 1 1.22 1 1.131 1 32 3.09 0 2 515.80902 -1.77 13.8 1030.61077

HLVPGAPFLLQALVR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

102 6 178557739;67190748

N-Term(iTRAQ4plex) 1.184 1 0.963 1 1.091 1 1.134 1 1.233 1 1.28 1 1.129 1 32 3.43 0 2 993.04163 8.72 18.97 1985.07598

HLYVLEFSDHPGIHEPLEPEVK

CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 6 1 4503011 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.047 1 1.021 1 1 1 0.979 1 1.118 1 1.094 1 1.118 1 3.43 0 3 432.58417 2.25 15.26 1295.73795

HNLYFEAAFDVPLK BTD biotinidase precursor [Homo sapiens]

686 NP_000051 6 1 4557373 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.37 1 1.063 1 1.331 1 1.252 1 1.495 1 1.406 1 1.123 1 3.19 0 2 709.32953 -2.3 24.83 1417.65178

HNPAIEALLHDLSSQR FAM20C dentin matrix protein 4 precursor [Homo sapiens]

56975 NP_064608 XP_098621

2 1 116174742 N-Term(iTRAQ4plex) 1.006 1 0.648 1 0.758 1 1.169 1 0.899 1 1.388 1 1.187 1 2.89 0 2 585.81689 1.73 14.4 1170.62651

HPDEAAFFDTASTGK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.301 1 0.863 1 1.152 1 1.335 1 1.273 1 1.475 1 1.105 1 72 4.02 0 2 767.36121 0.11 14.85 1533.71514

HPDLSIPELLR AFM afamin precursor [Homo sapiens] 173 NP_001124 8 1 4501987 N-Term(iTRAQ4plex) 1.036 1 1.04 1 1.056 1 1.015 1 1.057 1 1.016 1 1.001 1 56 3.98 0 3 645.33777 -0.96 52.92 1933.99875HPDMLTK CPB2 carboxypeptidase B2 isoform a

preproprotein [Homo sapiens]1361 NP_001863 1 2 126273569 N-Term(iTRAQ4plex);

K7(iTRAQ4plex)1.175 1 1.073 1 1.088 1 1.014 1 1.347 1 1.255 1 1.238 1 3.43 1 3 960.48944 6.21 58.17 2879.45377

HPLKPDNQPFPQSVSESCPGK

HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 10 1 4504489 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C18(Methylthio); K21(iTRAQ4plex)

1.285 1 0.887 1 1.13 1 1.273 1 1.295 1 1.459 1 1.146 1 66 4.21 0 2 734.93188 -2.69 33.08 1468.85649

HPNVFGFCR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 7 1 4504489 N-Term(iTRAQ4plex); C8(Methylthio)

1.31 2 0.1 0.91 2 22.3 1.172 2 11.1 1.288 2 11 1.337 2 10.3 1.469 2 11.9 1.141 2 0.8 43 3.23 0 2 555.81055 -4.34 23.75 1110.61382

HPPVQWAFQETSVESAVDTPFPAGIFVR

RARRES2 retinoic acid receptor responder protein 2 precursor [Homo sapiens]

5919 NP_002880 8 1 4506427 N-Term(iTRAQ4plex) 1.578 1 0.891 1 1.38 1 1.549 1 1.604 1 1.8 1 1.162 1 4.02 0 2 777.89136 -1.45 47.5 1554.77544

HPPVVMNGAVADGILASYATGSSVEYR

F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 4 1 110611237 N-Term(iTRAQ4plex) 1.269 1 0.994 1 1.156 1 1.163 1 1.374 1 1.383 1 1.189 1 26 0 2 805.37738 13.9 25.31 1609.74748

HPTITDEERRYIEESIGESANLLGAMEK

SLC17A6 vesicular glutamate transporter 2 [Homo sapiens]

57084 NP_065079 1 1 9966811 N-Term(iTRAQ4plex); M26(Oxidation); K28(iTRAQ4plex)

0.804 1 1.271 1 0.816 1 0.642 1 1.01 1 0.795 1 1.238 1 3.59 0 3 847.72729 -13.53 17.5 2541.16733

HPVTGQPSQDNCIFVVNEQTVATMTSEEK

PLEKHA5 pleckstrin homology domain-containing family A member 5 isoform 1 [Homo sapiens]

54477 NP_061885 3 3 19923493 N-Term(iTRAQ4plex); C12(Methylthio); K29(iTRAQ4plex)

1.7 1 0.898 1 1.638 1 1.824 1 1.588 1 1.769 1 0.97 1 3.51 1 3 589.67841 15.39 73.72 1767.02066

HQDFNSAVQLVENFCR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 108 1 4503635 N-Term(iTRAQ4plex); C15(Methylthio)

1.472 1 1.067 1 1.516 1 1.421 1 1.526 1 1.43 1 1.006 1 3.78 1 4 646.85077 -5.9 35.55 2584.38125

HQEHARHISFGGNLITFSPLQPGEF

DLGAP5 disks large-associated protein 5 isoform a [Homo sapiens]

9787 NP_055565 1 1 226371667 N-Term(iTRAQ4plex) 0.991 6 26.5 1.063 6 18.4 1.006 6 33.5 0.905 6 56.1 1.156 6 14.2 1.085 6 52.3 1.2 6 37 98 7.93 0 3 1077.5408 -0.58 69.71 3230.60703

HQFLLTGDTQGR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 30 1 21071030 N-Term(iTRAQ4plex) 1.946 2 45.6 0.869 2 30.6 1.489 2 90.1 1.713 2 50 2.145 2 45.8 2.467 2 13.8 1.441 2 34.4 82 7.89 0 3 1077.5408 -0.58 69.71 3246.59543

HQGTITVNEEGTQATTVTTVGFMPLSTQVR

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 120 1 73858566 N-Term(iTRAQ4plex) 1.181 5 7.4 0.988 5 18.5 1.082 5 32.1 1.095 5 21.1 1.487 5 24.3 1.391 5 25.9 1.17 5 12.4 67 7.53 0 3 850.45105 -1.8 49.76 2549.3386

HQGTITVNEEGTQATTVTTVGFMPLSTQVR

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 58 1 73858566 N-Term(iTRAQ4plex); M23(Oxidation)

61 3.82 0 2 644.328 -3.09 26.32 1287.64873

HQLYIDETVNSNIPTNLR FGB fibrinogen beta chain isoform 1 preproprotein [Homo sapiens]

2244 NP_005132 2 2 70906435 N-Term(iTRAQ4plex) 48 5.16 0 3 578.96954 0.51 33.97 1734.89408

HQMDLVATLSQLGLQELFQAPDLR

SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 74 2 115583663 N-Term(iTRAQ4plex); M3(Oxidation)

41 3.18 0 2 656.27667 2.64 18.51 1311.54607

HQMDLVATLSQLGLQELFQAPDLR

SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 54 2 115583663 N-Term(iTRAQ4plex) 2.92 0 2 481.30176 1.13 38.06 961.59624

HQNQWYTVCQTGWSLR CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 2 1 5174411 N-Term(iTRAQ4plex); C9(Methylthio)

0.833 6 9.2 0.962 6 12.4 0.794 6 6.4 0.8 6 16.3 0.858 6 2.9 0.879 6 10.4 1.077 6 3.5 75 5.93 0 3 1085.5027 0.64 34.6 2169.99479

HQPQEFPTYVEPTNDEICEAFR

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 376 2 32483410 N-Term(iTRAQ4plex); C18(Methylthio)

0.96 4 1.3 0.918 4 35 0.838 4 14.2 0.93 4 19.5 0.971 4 15.2 1.078 4 14.1 1.151 4 2.3 74 5.51 0 2 945.54993 -0.73 43.18 1890.09294

HQQTVTIPPK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 4 1 115298678 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.888 7 9.1 0.982 7 4.9 0.818 7 10.5 0.808 7 6 0.969 7 15.4 0.94 7 3.8 1.138 7 2.3 64 4.4 0 2 719.87079 2.74 63.16 1438.73039

HRLEDMEQALSPSVFK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 4 1 73858568 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.111 4 23.4 0.988 4 16.6 1.03 4 30 1.043 4 19.4 1.178 4 25.8 1.192 4 17.5 1.127 4 1.8 64 4.27 0 2 697.34033 -0.05 32.94 1393.67229

HRLEDMEQALSPSVFK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 1 1 73858568 N-Term(iTRAQ4plex); M6(Oxidation); K16(iTRAQ4plex)

0.947 4 4.2 1.002 4 0.5 0.917 4 1.5 0.925 4 2 0.951 4 8.9 1.046 4 9.1 1.107 4 7.1 63 5.92 0 2 885.95856 -2.54 39.14 1770.90984

HSCQAECSSELYTEASGYISSLEYPR

C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

134 1 66347875 N-Term(iTRAQ4plex); C3(Methylthio); C7(Methylthio)

0.98 4 14.9 0.908 4 14.4 0.879 4 20.1 0.948 4 9.1 0.99 4 18.6 1.123 4 5.2 1.154 4 4.4 61 3.52 0 2 684.42725 -2.11 24.6 1367.8449

HSIFTPETNPR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 6 1 4505881 N-Term(iTRAQ4plex) 0.8 8 24.3 0.81 8 44 0.618 8 42.5 0.774 8 30.6 0.655 8 38.7 1.028 8 27.6 1.29 8 20.9 61 7.84 0 3 1088.5618 0.72 54.15 3263.66965

HSITNPLAVLCEFISQSIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); C11(Methylthio); K19(iTRAQ4plex)

0.785 1 0.96 1 0.722 1 0.752 1 0.818 1 0.852 1 1.133 1 60 3.58 0 2 633.33594 2.35 20.89 1265.6646

HTFMGVVSLGSPSGEVSHPR

AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 63 1 156523970 N-Term(iTRAQ4plex) 1.004 3 2.9 0.828 3 4.6 0.784 3 3.9 0.991 3 1.1 1.008 3 5.8 1.181 3 17.3 1.183 3 18.4 59 7.76 0 3 1257.1438 -0.13 28.31 2513.27396

HTFMGVVSLGSPSGEVSHPR

AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 43 1 156523970 N-Term(iTRAQ4plex); M4(Oxidation)

0.927 5 9.2 0.963 5 12.4 0.904 5 7.4 0.938 5 4.6 0.983 5 14.6 1.003 5 18.8 1.051 5 2.8 57 6.72 0 3 577.28632 1.54 76.9 1729.84439

HTLNQIDEVK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 10 1 156523970 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.249 4 15.6 0.983 4 4.6 1.173 4 14.8 1.193 4 19.6 1.305 4 10.9 1.328 4 15.9 1.113 4 2.3 56 4.02 0 3 447.9454 -0.46 59.49 1341.82012

HTSLGPLEAK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 2 1 4557389 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.663 2 11.7 0.906 2 0.4 0.581 2 21.2 0.641 2 20.7 0.682 2 4.1 0.753 2 3.7 1.175 2 17 49 3.25 0 2 580.34387 0.1 41.44 1159.68047

HTSVQTTSSGSGPFTDVR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

19 6 47132549;16933542

N-Term(iTRAQ4plex) 0.906 2 3.2 1.018 2 0 0.853 2 4.9 0.838 2 5 0.975 2 1.7 0.957 2 1.7 1.143 2 3.2 45 3.68 0 2 632.82874 1.98 45.44 1264.64678

HVEDVPAFQALGSLNDLQFFR

AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 238 1 4502337 N-Term(iTRAQ4plex) 0.865 23 8 0.986 23 15 0.798 23 13.6 0.864 23 12 0.948 23 16.8 0.961 23 9.9 1.148 23 6.3 43 5.83 0 3 870.77045 -2.7 41.69 2610.29679

HVIILMTDGLHNMGGDPITVIDEIR

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 49 1 67782358 N-Term(iTRAQ4plex); M13(Oxidation)

0.921 1 0.894 1 0.822 1 0.92 1 0.922 1 1.032 1 1.122 1 41 2.9 0 2 634.85626 -2.14 30.44 1268.70525

HVIILMTDGLHNMGGDPITVIDEIR

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 69 1 67782358 N-Term(iTRAQ4plex) 1.065 1 0.886 1 0.986 1 1.113 1 1.023 1 1.155 1 1.038 1 39 4.65 0 3 577.28632 1.54 76.9 1745.83829

HVIILMTDGLHNMGGDPITVIDEIR

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 4 1 67782358 N-Term(iTRAQ4plex); M6(Oxidation); M13(Oxidation)

1.231 1 1.156 1 1.377 1 1.192 1 1.277 1 1.105 1 0.927 1 37 4.1 1 3 432.55923 1.41 12.74 1295.66315

HVIPMNPNTNDLFNAVGDGIVLCK

LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 9 1 167614506 N-Term(iTRAQ4plex); C23(Methylthio); K24(iTRAQ4plex)

1.202 1 0.964 1 1.128 1 1.17 1 1.232 1 1.279 1 1.093 1 30 0 2 632.82874 1.98 45.44 1280.64079

HVSSPLASYFLSFPYAR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 10 1 29171717 N-Term(iTRAQ4plex) 0.903 1 1.308 1 1.183 1 0.905 1 0.901 1 0.689 1 0.761 1 24 0 3 796.30322 0.98 69.41 2386.89511

HVVYPTAWMNQLPLLAAIEIQK

BTD biotinidase precursor [Homo sapiens]

686 NP_000051 44 1 4557373 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.349 1 0.858 1 1.179 1 1.375 1 1.326 1 1.546 1 1.125 1 26 0 2 421.80051 -0.82 40.95 842.59374

HVVYPTAWMNQLPLLAAIEIQK

BTD biotinidase precursor [Homo sapiens]

686 NP_000051 8 1 4557373 N-Term(iTRAQ4plex); M9(Oxidation); K22(iTRAQ4plex)

1.948 1 0.939 1 1.758 1 1.873 1 2.019 1 2.151 1 1.149 1 2.83 2 2 835.49786 -18.37 27 1669.98845

HYEGSTVPEK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 4 2 4826762 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.587 3 21.1 0.927 3 9 0.625 3 23.1 0.567 3 43.3 0.628 3 5.8 0.692 3 23.2 1.028 3 3.3 102 10.84 0 3 793.79199 0.64 79.12 2379.36142

HYEGSTVPEKK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 1 2 4826762 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K11(iTRAQ4plex)

1.399 1 0.91 1 1.274 1 1.4 1 1.398 1 1.535 1 1.097 1 2.81 1 2 1049.5852 8.3 54.61 2098.16313

HYQINQQWER FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 6 47132549;16933542

N-Term(iTRAQ4plex) 0.972 2 6.3 1.113 2 0.8 1.007 2 10.5 0.905 2 9.7 1.047 2 3.2 0.941 2 2.4 1.04 2 7.3 3.68 2 3 941.18781 11.32 51.4 2821.54886

HYYESEVLAMNFQDWATASR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 48 1 73858564 N-Term(iTRAQ4plex) 0.77 4 32.6 1.048 4 10.9 0.604 4 27.4 0.614 4 37.6 0.762 4 30.2 0.844 4 55.4 1.26 4 3.5 115 5.29 0 2 966.42999 -1.49 28.71 1931.85271

HYYESEVLAMNFQDWATASR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 15 1 73858564 N-Term(iTRAQ4plex); M10(Oxidation)

0.703 3 1.6 1.013 3 5.2 0.659 3 5.5 0.628 3 0.2 0.779 3 2.6 0.769 3 7.9 1.211 3 1.9 95 5.17 0 2 976.48212 -3.61 24.93 1951.95696

HYYIAAEEIIWNYAPSGIDIFTK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 60 1 4557485 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

0.48 3 10.8 1.037 3 0.1 0.458 3 24.8 0.441 3 7.7 0.521 3 14.7 0.515 3 3.8 1.228 3 7.7 76 7.5 0 3 774.46863 3.33 54.38 2321.39133

HYYIGIIETTWDYASDHGEK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 41 1 4557485 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

0.655 5 19.5 0.893 5 4.5 0.574 5 35.6 0.692 5 22.5 0.784 5 21.8 0.819 5 15.8 1.07 5 21.8 75 7.55 0 3 921.78912 -0.05 47.37 2763.34879

IACVLPVLMDGIQSHPQKPFYTVGEK

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 12 1 45580688 N-Term(iTRAQ4plex); C3(Methylthio); M9(Oxidation); K18(iTRAQ4plex); K26(iTRAQ4plex)

0.725 2 29.8 0.651 2 49.2 0.576 2 4.2 0.885 2 54.2 0.633 2 16.8 0.972 2 70.2 1.099 2 12.6 61 9.71 0 4 1276.99 6.25 73.82 3828.94985

IACVLPVLMDGIQSHPQKPFYTVGEK

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 20 1 45580688 N-Term(iTRAQ4plex); C3(Methylthio); K18(iTRAQ4plex); K26(iTRAQ4plex)

0.869 2 0.3 0.948 2 0.8 0.816 2 7.8 0.861 2 8.6 0.875 2 7.3 0.923 2 6.5 1.072 2 15.2 59 4.75 0 3 652.00946 2.19 33.1 1954.01383

IADAHLDR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 9 1 4504489 N-Term(iTRAQ4plex) 0.515 1 1.045 1 0.477 1 0.457 1 0.576 1 0.552 1 1.208 1 39 3.54 0 2 595.82007 0.69 34.15 1190.63286

IADFELPTIIVPEQTIEIPSIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 62 1 105990532 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

0.75 1 0.916 1 0.732 1 0.799 1 0.705 1 0.769 1 0.962 1 37 3.71 0 3 665.96228 4.37 17.56 1995.87229

IADVTSGLIGGEDGR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 9 1 29171717 N-Term(iTRAQ4plex) 1.017 1 0.848 1 0.8 1 0.944 1 1.079 1 1.272 1 1.348 1 5.23 0 3 984.79663 2.98 63.81 2952.37534

IAELSATAQEIIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 105 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.622 1 0.88 1 0.547 1 0.622 1 0.623 1 0.708 1 1.138 1 3.47 0 2 603.323 -0.68 15.11 1205.63872

IAEYMNHLIDIGVAGFR AMY2A pancreatic alpha-amylase precursor [Homo sapiens]

279 NP_000690 XP_003960156

1 3 4502085 N-Term(iTRAQ4plex) 0.818 5 15.1 0.955 5 23.1 0.734 5 32.9 0.826 5 10.7 0.865 5 25.9 0.985 5 5.6 1.2 5 6.9 92 5.26 0 3 905.46674 -1.86 36.26 1809.93381

IAIANIIDEIIEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 28 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.561 1 0.937 1 1.468 1 1.567 1 1.555 1 1.66 1 1.059 1 78 0 2 905.46674 -1.86 36.26 1825.92034

IAIDLFK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 101 1 73858566 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.936 3 4.9 0.943 3 10.5 0.818 3 15.4 0.937 3 4.4 1.001 3 11.5 1.069 3 1 1.194 3 3.5 65 5.36 0 2 811.89026 -0.93 21.78 1622.77336

IALGGLLFPASNLR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 6 4 7382460 N-Term(iTRAQ4plex) 0.86 1 0.826 1 0.743 1 0.899 1 0.828 1 1.003 1 1.115 1 65 4.03 0 2 759.8288 -4.04 23.98 1518.65032

IALTDNALIAR RPL7 60S ribosomal protein L7 [Homo sapiens]

6129 NP_000962 1 1 15431301 N-Term(iTRAQ4plex) 1.049 6 7.5 1.032 6 12.6 0.982 6 16.9 0.962 6 3.2 1.125 6 12.8 1.075 6 7.1 1.149 6 3.3 52 3.67 0 2 609.86115 -3.5 35.72 1218.71819

IAPANADFAFR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 10 1 21361302 N-Term(iTRAQ4plex) 0.88 3 7.2 0.933 3 9.9 0.806 3 9.5 0.862 3 0.4 0.896 3 14.3 0.96 3 4.3 1.14 3 0.9 47 3.83 0 2 604.7851 -0.31 27.33 1208.56389

IAPPPVVSSGPFLFIK NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 2 5 66864913 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.767 1 1.037 1 0.729 1 0.703 1 0.834 1 0.804 1 1.144 1 30 2.76 0 2 578.74115 -8.83 20.86 1156.47502

IAPQLSTEELVSLGEK AFM afamin precursor [Homo sapiens] 173 NP_001124 101 1 4501987 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.682 1 0.973 1 1.534 1 1.576 1 1.786 1 1.835 1 1.165 1 48 6.28 0 3 635.99908 -0.02 30.79 1905.9827

IAQLPLTGSMSIIFFLPLK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 6 1 39725934 N-Term(iTRAQ4plex); M10(Oxidation); K19(iTRAQ4plex)

1.357 1 0.838 1 1.132 1 1.35 1 1.362 1 1.626 1 1.204 1 3.59 1 3 1174.8987 1.54 47.91 3522.68149

IAQLPLTGSMSIIFFLPLK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 32 1 39725934 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.363 1 0.934 1 1.293 1 1.384 1 1.343 1 1.438 1 1.039 1 4.04 2 3 1000.8179 -0.07 42.69 3000.43924

IAQWQSFQLEGGLK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 20 1 66932947 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.292 1 1.087 1 1.257 1 1.156 1 1.439 1 1.324 1 1.145 1 2.86 1 2 879.96442 14.29 18.23 1758.92156

IAQWQSLK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 4 1 162809334 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.655 2 15.8 0.859 2 13.2 0.557 2 20.8 0.649 2 7.5 0.662 2 23 0.771 2 9.6 1.189 2 2.1 38 4.67 0 2 882.98291 -8.46 39.51 1764.95854

IAQYYYTFK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 15 1 110611237 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

50 3.08 0 2 558.32025 -0.65 28.18 1115.63323

IASFSQNCDIYPGK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

191 3 4504893;156231037

N-Term(iTRAQ4plex); C8(Methylthio); K14(iTRAQ4plex)

1.341 1 0.923 1 1.226 1 1.328 1 1.353 1 1.465 1 1.103 1 3.79 1 4 741.63367 3.19 54.7 2963.51284

IASFSQNCDIYPGKDFVQPPTK

KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

3 3 4504893;156231037

N-Term(iTRAQ4plex); C8(Methylthio); K14(iTRAQ4plex); K22(iTRAQ4plex)

1.21 1 0.872 1 1.061 1 1.217 1 1.204 1 1.381 1 1.135 1 2.77 1 2 854.96375 -15.83 22.36 1708.92021

IAWESPQGQVSR FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 2 3 16933542 N-Term(iTRAQ4plex) 0.917 2 11 0.994 2 7.3 0.855 2 15.7 0.86 2 8.3 0.974 2 13.8 0.98 2 6.4 1.139 2 1.9 61 0 2 616.39978 -7.63 35.99 1231.79228

IAYGTQGSSGYSLR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 8 1 78191798 N-Term(iTRAQ4plex) 1.062 1 0.852 1 0.877 1 1.03 1 1.089 1 1.279 1 1.241 1 50 3.74 0 2 695.36401 8.39 27.09 1389.72075

ICAMEGLPQK AFM afamin precursor [Homo sapiens] 173 NP_001124 16 1 4501987 N-Term(iTRAQ4plex); C2(Methylthio); K10(iTRAQ4plex)

1.131 1 1.11 1 1.083 1 0.975 1 1.303 1 1.174 1 1.204 1 50 4.3 0 3 667.3811 1.03 35.73 2000.12876

ICAMEGLPQK AFM afamin precursor [Homo sapiens] 173 NP_001124 2 1 4501987 N-Term(iTRAQ4plex); C2(Methylthio); M4(Oxidation); K10(iTRAQ4plex)

1.185 2 8 0.955 2 4.6 1.227 2 5.3 1.284 2 0.6 1.083 2 18.2 1.134 2 23 0.883 2 23.6 50 0 3 657.03949 0.07 76.83 1969.10392

ICDLLVANNHFAHFFAPQNLTNMNK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 2 2 156119625 N-Term(iTRAQ4plex); C2(Methylthio); K25(iTRAQ4plex)

1.037 1 0.829 1 0.891 1 1.076 1 1.005 1 1.213 1 1.127 1 41 3.13 0 2 614.32928 -0.91 22.59 1227.65129

ICDLLVANNHFAHFFAPQNLTNMNK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 2 2 156119625 N-Term(iTRAQ4plex); C2(Methylthio); M23(Oxidation); K25(iTRAQ4plex)

1.072 1 0.963 1 0.965 1 1.003 1 1.139 1 1.183 1 1.18 1 38 3.74 0 2 644.37488 -5.96 18.8 1287.74248

ICEMIQK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 13 1 31652249 N-Term(iTRAQ4plex); C2(Methylthio); K7(iTRAQ4plex)

1.633 1 0.863 1 1.413 1 1.637 1 1.629 1 1.888 1 1.153 1 46 3.54 0 2 739.40491 -0.18 64.31 1477.80254

ICLDLQALLYK PF4V1 platelet factor 4 variant precursor [Homo sapiens]

5197 NP_002611 4 1 4505735 N-Term(iTRAQ4plex); C2(Methylthio); K11(iTRAQ4plex)

1.267 1 0.944 1 1.099 1 1.164 1 1.363 1 1.444 1 1.24 1 34 4.89 0 3 550.32086 -1.96 34.47 1648.94803

ICLDLQAPLYK PF4 platelet factor 4 precursor [Homo sapiens]

5196 NP_002610 18 1 4505733 N-Term(iTRAQ4plex); C2(Methylthio); K11(iTRAQ4plex)

0.792 3 28.6 1.056 3 13.7 0.716 3 10.7 0.905 3 0.5 0.709 3 2.3 0.963 3 11.4 1.064 3 10.9 46 3.13 0 2 545.35785 -3.46 23.89 1089.71135

ICLDPDAPR PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 13 1 4505981 N-Term(iTRAQ4plex); C2(Methylthio)

1.241 1 1.07 1 1.094 1 1.022 1 1.474 1 1.379 1 1.348 1 3.87 2 4 670.5835 -4.85 43.26 2679.31215

ICMDEDGNEK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex); C2(Methylthio); K10(iTRAQ4plex)

1.354 1 1.04 1 1.242 1 1.194 1 1.52 1 1.461 1 1.223 1 27 0 3 357.89725 0.67 12.09 1071.67719

ICVGCPR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

2 3 4504893;156231037

N-Term(iTRAQ4plex); C2(Methylthio); C5(Methylthio)

0.835 1 0.891 1 0.69 1 0.774 1 0.89 1 0.998 1 1.289 1 58 5.56 0 2 816.40442 -1.11 34.47 1631.80156

IDDIWNLEVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 74 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

63 5.24 0 3 974.55029 -3.14 53.51 1948.09586

IDFLNNYALFLSPSAQQASWQVSAR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 35 1 105990532 N-Term(iTRAQ4plex) 1.595 1 0.967 1 1.373 1 1.42 1 1.764 1 1.824 1 1.285 1 3.19 0 2 624.82758 -0.69 32.65 1248.64787

IDLADFEK FGL1 fibrinogen-like protein 1 precursor [Homo sapiens]

2267 NP_004458 XP_942979 XP_948560

4 1 42544189 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.559 1 0.841 1 1.349 1 1.604 1 1.521 1 1.809 1 1.128 1 3.02 0 2 627.34491 -2.61 22.33 1253.68254

IDQNVEELK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 28 1 71773110 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.426 10 15.8 0.935 10 27.6 1.274 10 16.7 1.314 10 16.5 1.412 10 12.5 1.616 10 21.9 1.157 10 19.9 3.98 1 3 795.08459 -16.73 38.59 2383.23923

Page 20: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

IDQTVEELR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 20 1 71773110 N-Term(iTRAQ4plex) 0.334 1 1.015 1 0.322 1 0.317 1 0.351 1 0.346 1 1.092 1 88 5.57 0 2 741.88788 1.04 18.36 1482.76848

IDQTVEELRR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 1 1 71773110 N-Term(iTRAQ4plex) 0.589 3 49.8 1.015 3 6.8 0.58 3 62.6 0.546 3 54.1 0.636 3 46.7 0.598 3 39 1.096 3 11.6 85 4.67 0 2 775.4007 0.15 14.58 1549.79411

IDSGLYLGSGYFTAIQNLR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex) 102 5.37 0 2 795.42816 -8.49 20.57 1589.84905

IDSLLENDR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 30 1 355594753 N-Term(iTRAQ4plex) 86 3.69 0 2 754.91162 7.49 17.39 1508.81597

IDTALIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 10 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.85 0 2 620.31885 -0.18 38.81 1239.63042

IDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 15 1 4557485 N-Term(iTRAQ4plex); M16(Oxidation); M25(Oxidation); C28(Methylthio); K35(iTRAQ4plex)

42 3.35 0 2 587.35034 -2.21 27.87 1173.69341

IDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 15 1 4557485 N-Term(iTRAQ4plex); M16(Oxidation); C28(Methylthio); K35(iTRAQ4plex)

51 3.15 0 2 549.32855 4.86 22.73 1097.64983

IDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 5 1 4557485 N-Term(iTRAQ4plex); C28(Methylthio); K35(iTRAQ4plex)

44 3.94 0 2 617.8252 8.12 28.86 1234.64482

IDTQDIEASHYR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 16 2 38016947 N-Term(iTRAQ4plex) 44 2.83 0 2 617.8252 8.12 28.86 1250.62944

IDVCPENAEVTLTDFR THBS4;COMP

thrombospondin-4 precursor [Homo sapiens];cartilage oligomeric matrix protein precursor [Homo sapiens]

7060;1311 NP_003239;NP_000086

2 2 31543806;40217843

N-Term(iTRAQ4plex); C4(Methylthio)

1.399 4 5.1 0.904 4 1.4 1.22 4 5.8 1.366 4 7.6 1.373 4 5.3 1.588 4 11.7 1.125 4 8.9 95 7.63 0 3 651.01166 -1.25 57.98 1951.02042

IDVHLVPDR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 13 1 62739186 N-Term(iTRAQ4plex) 2.079 2 30.9 1.008 2 11.7 1.937 2 20.7 1.922 2 33 2.239 2 28.2 2.222 2 40.9 1.156 2 7.2 75 7.45 0 3 651.01166 -1.25 57.98 1967.02127

IDVHWTR AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 2 1 4502337 N-Term(iTRAQ4plex) 1.074 2 4.5 0.91 2 21.2 0.985 2 14.6 1.083 2 6.5 1.07 2 14.7 1.176 2 6.4 1.086 2 0.1 74 5.13 0 2 815.43628 -4.54 35.06 1629.86528

IDWNHITLENISSGSSLNVKAGCVRK

CRB1 crumbs homolog 1 isoform 2 precursor [Homo sapiens]

23418 NP_001180569 1 2 302370926 N-Term(iTRAQ4plex); K20(iTRAQ4plex); C23(Methylthio); K26(iTRAQ4plex)

1.462 5 10.4 0.831 5 51 1.074 5 19.1 1.346 5 10 1.266 5 43.7 1.554 5 6.7 1.178 5 0.8 64 8.21 0 3 798.79211 0.29 60.73 2394.35923

IEDANLIPPVPDDK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 5 1 40317626 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.649 3 3.4 0.955 3 7 1.494 3 13.4 1.696 3 1.4 1.731 3 10.5 1.976 3 8.2 1.159 3 0.6 63 4.03 0 2 640.34436 3.99 34.18 1279.67473

IEDANLIPPVPDDKFQDLVDAVR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 1 40317626 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.911 1 0.709 1 1.557 1 2.195 1 1.71 1 2.41 1 1.098 1 49 7.45 1 4 560.55872 -0.79 41.9 2239.21303

IEDGTLASK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.468 1 0.947 1 1.358 1 1.434 1 1.5 1 1.583 1 1.104 1 44 4.3 0 2 912.01263 -0.25 40.37 1823.01799

IEDLPTMVTLGNSFLHK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 14 1 89191868 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.385 1 0.997 1 1.275 1 1.279 1 1.49 1 1.495 1 1.169 1 36 6.44 0 3 830.07416 3.8 62.7 2488.20792

IEDLPTMVTLGNSFLHK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); M7(Oxidation); K17(iTRAQ4plex)

1.135 1 1.13 1 1.188 1 1.051 1 1.229 1 1.088 1 1.035 1 4.3 0 3 670.05713 -1.18 31.37 2008.15683

IEEADCK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 1 1 169636415 N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

1.276 1 1.078 1 1.112 1 1.032 1 1.54 1 1.428 1 1.385 1 3.75 0 3 875.43213 -13.43 56.13 2624.28183

IEEIAAK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.435 1 1.196 1 1.487 1 1.243 1 1.664 1 1.391 1 1.119 1 78 4.58 0 2 891.48041 0.63 33.98 1781.95354

IEFEWNTGTNVDTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 74 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.056 1 0.854 1 0.905 1 1.059 1 1.053 1 1.233 1 1.164 1 33 3.06 0 2 653.36652 -2.01 27.42 1305.72576

IEFISTMEGYK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 6 1 4503987 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.073 2 15.2 0.964 2 0.8 0.96 2 9.8 0.996 2 9 1.147 2 20.5 1.19 2 19.7 1.195 2 10.6 91 6.7 0 3 1328.0508 0.82 43.04 2655.09061

IEGDEEMHCSDDGFWSK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 46 2 62739186 N-Term(iTRAQ4plex); C9(Methylthio); K17(iTRAQ4plex)

1.051 7 7.6 0.948 7 8.7 0.945 7 8.6 0.981 7 7.6 1.05 7 5.3 1.104 7 8.1 1.129 7 16.5 84 5.24 0 2 973.99823 2.09 28.4 1946.99004

IEGDEEMHCSDDGFWSK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 2 2 62739186 N-Term(iTRAQ4plex); M7(Oxidation); C9(Methylthio); K17(iTRAQ4plex)

1.241 9 18.7 0.994 9 11.3 1.137 9 11.3 1.139 9 15.4 1.4 9 15.5 1.336 9 25.5 1.157 9 3.6 81 5.55 0 3 945.53418 -4.08 38.39 1890.06108

IEGNLIFDPNNYLPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 45 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.218 6 2.4 0.985 6 9.1 1.163 6 9.6 1.21 6 4.2 1.24 6 7.5 1.322 6 13.9 1.11 6 8.3 79 6 0 3 1001.5394 -1.49 52.65 2002.07682

IEIPLPFGGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 60 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.973 9 35.2 0.9 9 27.2 0.777 9 39.9 0.909 9 48.7 0.921 9 71.7 1.142 9 25.5 1.151 9 35 69 10.37 0 3 1111.9731 0.7 80.86 3333.91037

IEIWVMHEIGGPNVESCGEGSMK

BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 2 1 168229159 N-Term(iTRAQ4plex); C17(Methylthio); K23(iTRAQ4plex)

1.088 9 12.4 0.963 9 8.5 1.016 9 13.5 1.031 9 12.1 1.176 9 16.8 1.163 9 9.7 1.162 9 4.9 66 5.38 0 2 716.86993 1.69 40.09 1432.73027

IELEDWK ANGPTL3 angiopoietin-related protein 3 precursor [Homo sapiens]

27329 NP_055310 2 1 7656888 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.583 7 10.4 0.951 7 19.3 1.525 7 13.3 1.493 7 8.5 1.77 7 12.3 1.722 7 1.1 1.154 7 2.4 63 3.49 0 2 595.88495 2.3 36.19 1190.7542

IEMSK FBXO3 F-box only protein 3 isoform 2 [Homo sapiens]

26273 NP_208385 1 2 15812188 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.015 91 7.8 0.936 91 12.3 0.927 91 11.4 0.984 91 9.4 1.053 91 14.8 1.102 91 8.1 1.123 91 9 60 6.56 0 4 1284.6725 1.56 62 2568.33769

IEPSQAK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

1 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.178 3 9.1 0.891 3 0.8 1.096 3 4 1.137 3 5.3 1.127 3 1.4 1.271 3 2.2 1.143 3 9 59 7.6 0 3 716.72943 -0.9 54.92 2148.1785

IETISHEDLQR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 9 1 192447438 N-Term(iTRAQ4plex) 0.982 2 16.1 0.815 2 17.1 0.807 2 26.8 0.991 2 9.4 0.977 2 21.6 1.199 2 4.3 1.211 2 5 58 3.96 0 2 671.8949 -8.04 16.08 1342.78252

IEWLESHQDADIEDFK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 4 1 16507237 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.92 9 11.5 0.97 9 4 0.891 9 11.5 0.888 9 11.6 0.998 9 8.4 1.022 9 6.8 1.12 9 3 46 3.38 0 2 516.81201 -0.26 21.37 1032.61662

IFELFEVGFLSPATFTVYEYHRPDK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.431 4 29.6 0.999 4 6 1.325 4 33 1.382 4 26.6 1.478 4 32.7 1.542 4 26.3 1.113 4 6.3 45 3.56 0 2 628.86481 -0.7 47.31 1256.72234

IFFESVYGQCK FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 20 1 58331240 N-Term(iTRAQ4plex); C10(Methylthio); K11(iTRAQ4plex)

0.949 2 17.4 1.124 2 27.6 0.961 2 4.2 0.855 2 32.1 1.063 2 1.8 0.946 2 29.5 1.106 2 2.4 43 4.03 0 3 462.28619 -8.29 23.43 1384.84403

IFFHLNAVALGDGGHYTCR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 41 1 21071030 N-Term(iTRAQ4plex); C18(Methylthio)

1.194 2 18.8 0.925 2 1 1.063 2 18.9 1.149 2 20 1.235 2 17.8 1.336 2 18.9 1.163 2 1.1 41 4.55 0 2 958.01831 -0.02 47.36 1915.02934

IFFPGVSEFGK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 17 1 4557351 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.682 2 6.7 0.678 2 38.6 0.607 2 28 0.895 2 9.7 0.546 2 15.4 0.806 2 22.2 0.9 2 12.2 41 9.31 0 4 1055.0635 4.72 80.17 4217.23208

IFFYDSENPPASEVLR PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 8 1 19923106 N-Term(iTRAQ4plex) 1.355 1 1.18 1 1 1 0.848 1 1.954 1 1.656 1 1.953 1 39 8.31 0 4 1071.8315 -0.98 80.95 4284.30434

IFLCQGK MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 2 1 71274107 N-Term(iTRAQ4plex); C4(Methylthio); K7(iTRAQ4plex)

1.066 4 3.4 0.977 4 2.1 0.992 4 6 1.041 4 6.4 1.122 4 4.4 1.15 4 2 1.112 4 1.7 32 0 2 450.21396 1.2 12.27 899.42064

IFLNWK PTPRK receptor-type tyrosine-protein phosphatase kappa isoform b precursor [Homo sapiens]

5796 NP_002835 1 2 18860902 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.755 3 10.3 1.131 3 27.4 1.961 3 151.8 1.157 3 22.7 1.779 3 109.4 1.16 3 16.7 1.003 3 5.8 29 9.49 0 4 1071.8315 -0.98 80.95 4300.32876

IFQEPTEPK RRM2 ribonucleoside-diphosphate reductase subunit M2 isoform 2 [Homo sapiens]

6241 NP_001025 1 2 4557845 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.695 1 0.905 1 1.464 1 1.618 1 1.764 1 1.949 1 1.204 1 5.61 0 3 716.72943 -0.9 54.92 2164.16855

IFSFDGK COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 1 2 110611233 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.315 1 1.013 1 1.234 1 1.219 1 1.413 1 1.395 1 1.145 1 3.11 0 2 553.30359 1.83 37.67 1105.5999

IFSPFADLSELSATGR SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 14 1 7705879 N-Term(iTRAQ4plex) 1.672 1 1.201 1 1.784 1 1.486 1 1.896 1 1.579 1 1.063 1 31 0 2 544.85498 -4.01 36.93 1088.70268

IFSQETLTK PCYOX1 prenylcysteine oxidase 1 precursor [Homo sapiens]

51449 NP_057381 4 1 166795301 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.665 2 3.5 0.987 2 26.5 1.506 2 11.1 1.525 2 15.1 1.815 2 21.1 1.838 2 5.2 1.205 2 9.9 4.03 2 4 735.36719 -3.39 61.94 2938.44692

IFYNQQNHYDGSTGK ADIPOQ adiponectin precursor [Homo sapiens]

9370 NP_004788 4 1 4757760 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.916 3 11.8 0.986 3 7.9 1.736 3 12.9 1.921 3 6.3 1.84 3 12.1 2.125 3 9.1 1.12 3 7.3 3.6 2 3 576.66925 17.25 41.62 1727.9932

IGDLHPQIVNLLK COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 4 5 55743098 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.825 1 0.965 1 1.749 1 1.813 1 1.837 1 1.904 1 1.05 1 4.03 2 3 863.45825 2.86 40.16 2588.3602

IGDQWDK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 6 47132549;16933542

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.062 3 9.9 0.992 3 4.7 0.959 3 14.9 1.001 3 5.2 1.05 3 14.3 1.078 3 7.5 1.077 3 16.8 99 10.17 0 3 836.81921 0.08 73.73 2508.44712

IGDTWSK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

6 6 47132549;16933542

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.049 1 0.957 1 0.924 1 0.965 1 1.13 1 1.181 1 1.223 1 70 7.52 0 3 963.83826 0.56 44.85 2889.50022

IGEHTPSALAIMENANVLAR ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens]

226 NP_000025 2 3 4557305 N-Term(iTRAQ4plex) 1.21 1 0.851 1 1.034 1 1.215 1 1.205 1 1.416 1 1.166 1 66 3.79 0 2 661.88672 -3.75 40.17 1322.76616

IGEIKEETTSHLR KNG1 kininogen-1 isoform 2 precursor [Homo sapiens]

3827 NP_000884 5 2 4504893 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

0.818 4 13.4 0.94 4 6.1 0.754 4 14.5 0.803 4 8.3 0.833 4 10.1 0.879 4 3.4 1.001 4 11 36 4.29 0 3 736.40094 2 57.27 2207.18827

IGESIELTCPK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 24 1 169636415 N-Term(iTRAQ4plex); C9(Methylthio); K11(iTRAQ4plex)

1.242 1 0.89 1 1.1 1 1.236 1 1.248 1 1.402 1 1.135 1 3.59 0 3 714.71863 10.97 41.93 2142.14133

IGFGQCAGK FAH fumarylacetoacetase [Homo sapiens]

2184 NP_000128 2 1 4557587 N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

1.178 1 0.851 1 1.011 1 1.188 1 1.17 1 1.375 1 1.157 1 3.47 2 3 819.42987 -1.9 43.15 2456.27506

IGFPWSEIR MSN moesin [Homo sapiens] 4478 NP_002435 1 3 4505257 N-Term(iTRAQ4plex) 1.588 1 1.166 1 1.733 1 1.485 1 1.707 1 1.463 1 0.985 1 3.68 2 3 848.80005 -0.05 18.96 2544.38559IGGAIEEVYVSLGVSVGK C8B complement component C8 beta

chain preproprotein [Homo sapiens]732 NP_000057 5 1 4557391 N-Term(iTRAQ4plex);

K18(iTRAQ4plex)1.26 1 0.946 1 1.118 1 1.182 1 1.335 1 1.411 1 1.194 1 62 7.5 0 3 772.65533 1.03 49.81 2315.95145

IGGSYK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 6 1 4557485 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.861 1 0.972 1 0.894 1 0.92 1 0.803 1 0.826 1 0.897 1 55 5.47 0 3 576.21655 -3.44 20.37 1726.6351

IGNFSTDIK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 1 167614506 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.991 1 1.064 1 0.955 1 0.897 1 1.091 1 1.025 1 1.142 1 52 4.38 0 2 855.38672 -3.53 25.49 1709.76616

IGQDGISTSATTNLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 43 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.017 1 0.902 1 0.889 1 0.985 1 1.045 1 1.158 1 1.175 1 41 3.64 0 2 711.37396 0.92 36.3 1421.74065

IGVELTGR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex) 1.063 1 1.016 1 0.878 1 0.865 1 1.265 1 1.245 1 1.44 1 31 0 3 574.29822 -2.49 18.37 1720.8801

IGWPNAPILIQDFETLPR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 5 1 89191868 N-Term(iTRAQ4plex) 1.183 1 0.955 1 1.086 1 1.137 1 1.227 1 1.285 1 1.13 1 21 3.09 0 2 666.23517 -1.11 40.22 1331.46306

IGYCPQFDALLDHMTGREMLVMYAR

ABCA3 ATP-binding cassette sub-family A member 3 [Homo sapiens]

21 NP_001080 1 1 116734710 N-Term(iTRAQ4plex); C4(Methylthio); M14(Oxidation)

1.001 1 0.871 1 0.917 1 1.053 1 0.956 1 1.097 1 1.042 1 7.21 0 4 884.93658 2.54 61.93 3536.72451

IHALGPNYNLVISDLR CD84 SLAM family member 5 isoform 3 precursor [Homo sapiens]

8832 NP_001171810 2 3 296434290 N-Term(iTRAQ4plex) 1.616 1 1.008 1 1.534 1 1.521 1 1.711 1 1.697 1 1.115 1 30 1 2 561.78668 3.63 14.79 1122.56609

IHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

17 2 31542984;262050538

N-Term(iTRAQ4plex) 1.973 14 12.4 0.953 14 12.6 1.774 14 23 1.877 14 10.8 2.009 14 16.9 2.063 14 8.6 1.118 14 8.2 50 4.22 0 3 390.87488 0.37 0.48 1170.61045

IHILPSMNPDGYEVAAAQGPNKPGYLVGR

CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 13 1 4503011 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

2.038 1 1.065 1 1.984 1 1.863 1 2.225 1 2.089 1 1.122 1 3.69 2 3 934.48523 2.14 39.15 2801.44114

IHLISTQSAIPYALR FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 1 2 70906437 N-Term(iTRAQ4plex) 1.31 2 7 1.213 2 24.6 1.319 2 16.9 1.087 2 7.5 1.59 2 23.4 1.311 2 1.1 1.206 2 6.3 66 5.71 0 2 1089.5153 1.94 24.79 2178.02324

IHSGSFQSQVELSNDQEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.195 2 5.8 0.983 2 3.7 1.111 2 5.9 1.13 2 9.6 1.258 2 2.3 1.28 2 5.9 1.133 2 3.6 56 4.19 1 2 916.47913 -8.11 24.25 1831.95098

IIANALSSEPACLAEIEEDKAR

PRKDC DNA-dependent protein kinase catalytic subunit isoform 2 [Homo sapiens]

5591 NP_001075109 1 2 126032350 N-Term(iTRAQ4plex); C12(Methylthio); K20(iTRAQ4plex)

0.942 2 15.8 1.01 2 38.7 0.903 2 8.8 0.894 2 29.2 1.004 2 2 0.994 2 41 1.112 2 10.8 54 3.6 0 2 641.85938 -1.44 18.41 1282.71147

IIDGGSGYLCEMEPVAHFGLGK

CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 4 2 330688397 N-Term(iTRAQ4plex); C10(Methylthio); K22(iTRAQ4plex)

1.304 1 0.927 1 1.191 1 1.286 1 1.32 1 1.425 1 1.108 1 49 6.89 0 3 777.36914 1.57 58.72 2330.09287

IIDGVPVEITEK POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 2 4 209863034 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.103 3 7.6 0.915 3 24.7 1.006 3 6.5 1.148 3 4.3 1.179 3 5 1.332 3 1 1.161 3 1.5 30 3.39 0 2 601.32574 -3.67 31.45 1201.64421

IIEFLQADMTK SAMD3 sterile alpha motif domain-containing protein 3 isoform b [Homo sapiens]

154075 NP_689765 4 2 126032345 N-Term(iTRAQ4plex); M9(Oxidation); K11(iTRAQ4plex)

1.501 3 2.7 0.904 3 4.8 1.326 3 8 1.548 3 4.6 1.428 3 3.6 1.671 3 16.9 1.08 3 4 71 5.4 0 3 1095.9812 2.62 46.44 2190.94974

IIEGGIYDADLNDER CST2 cystatin-SA precursor [Homo sapiens]

1470 NP_001313 2 1 4503105 N-Term(iTRAQ4plex) 2.764 3 34.3 0.953 3 29.5 2.798 3 21.1 2.414 3 3.5 3.17 3 16.5 2.75 3 0.8 1.133 3 4.3 66 4.05 0 2 708.35199 -10.3 14.77 1415.6967

IIEVEEEQEDPYLNDR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

7 4 34734066;34734062

N-Term(iTRAQ4plex) 1.712 1 0.976 1 1.597 1 1.636 1 1.786 1 1.83 1 1.118 1 2.8 0 2 472.75693 -0.51 14.25 944.50658

IIFGYK PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

63 4.39 0 2 739.84833 -2.6 34.44 1478.68938

IIFHENYNAGTYQNDIALIEMK

CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 84 1 119392081 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

37 0 2 553.8064 8.35 29.34 1106.60552

IIFHENYNAGTYQNDIALIEMK

CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 2 1 119392081 N-Term(iTRAQ4plex); M21(Oxidation); K22(iTRAQ4plex)

29 0 2 739.84833 -2.6 34.44 1494.6895

IIGGQK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

1 1 66347875 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

59 3.83 0 2 711.4259 -4.39 19.03 1421.84331

IIGGSDADIK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 5 1 41393602 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.349 20 10.4 1.033 20 13.7 1.274 20 20.5 1.255 20 7.2 1.485 20 16.7 1.431 20 4.8 1.127 20 3.1 39 0 2 512.83588 -0.02 25.71 1024.66448

IIIIK IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 2 5 62243068 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.048 1 0.761 1 0.9 1 1.183 1 0.945 1 1.242 1 1.05 1 3.69 1 3 945.49939 -18.62 28.63 2834.48362

IIILR DNAH12 dynein heavy chain 12, axonemal isoform 1 [Homo sapiens]

201625 NP_848599 XP_001134410 XP_001134433

1 1 194440727 N-Term(iTRAQ4plex) 1.054 3 26.8 0.846 3 19.3 0.926 3 52.4 1.203 3 34.2 0.783 3 15.4 1.188 3 11 1.063 3 22.6 81 9.85 0 3 1102.8629 1.55 57.31 3306.57419

IINEPTAAAIAYGLDK HSPA8;HSPA5

heat shock cognate 71 kDa protein isoform 2 [Homo sapiens];78 kDa glucose-regulated protein precursor [Homo sapiens]

3312;3309 NP_694881;NP_005338

8 5 24234686;16507237

N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.112 2 8.5 1.003 2 3.7 1.057 2 8.6 1.053 2 4.9 1.171 2 11.9 1.167 2 8.2 1.108 2 3.3 76 8.55 0 3 754.72211 0.71 35.54 2262.15177

IIPGGIYDADLNDEWVQR CST4 cystatin-S precursor [Homo sapiens]

1472 NP_001890 2 1 4503109 N-Term(iTRAQ4plex) 0.948 1 0.887 1 0.812 1 0.916 1 0.976 1 1.101 1 1.202 1 75 3.71 0 2 997.45703 0.83 51.3 1993.90679

IIPGGIYNADLNDEWVQR CST1 cystatin-SN precursor [Homo sapiens]

1469 NP_001889 1 1 19882251 N-Term(iTRAQ4plex) 0.973 2 5.9 0.861 2 5.1 0.861 2 6.4 1 2 1.4 0.95 2 10 1.103 2 4.9 1.103 2 3.5 69 5.13 0 3 842.4353 -3 19.97 1683.86405

IISDYHQQFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex) 1.126 2 3.3 0.997 2 6.6 0.981 2 3.5 0.985 2 3 1.267 2 8.9 1.271 2 2.3 1.291 2 5.3 52 5.82 0 3 629.39154 0.23 49.23 1886.16007

IISIMDEK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 4 1 162809334 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.79 1 0.73 1 0.628 1 0.861 1 0.738 1 1.011 1 1.175 1 34 0 2 475.28256 -4.52 33.25 949.55785

IISNEEGYR DPP4 dipeptidyl peptidase 4 [Homo sapiens]

1803 NP_001926 1 1 18765694 N-Term(iTRAQ4plex) 1.439 1 0.973 1 1.295 1 1.331 1 1.545 1 1.588 1 1.193 1 41 4.74 0 3 539.60529 -8.44 20.64 1616.8013

IIWELIK IDH1 isocitrate dehydrogenase [NADP] cytoplasmic [Homo sapiens]

3417 NP_005887 1 1 28178825 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.324 3 0.7 0.923 3 0.2 1.212 3 0.7 1.228 3 2.1 1.326 3 0.7 1.439 3 0.9 1.164 3 3.9 3.89 1 3 843.12122 15.62 60.51 2527.34909

IKFEMEQNLR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.401 1 1.093 1 1.401 1 1.282 1 1.531 1 1.401 1 1.093 1 4.04 0 3 791.35944 0.65 35.57 2372.06375

IKSEASPRPLK MYCN N-myc proto-oncogene protein [Homo sapiens]

4613 NP_005369 1 1 19923312 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex)

0.954 2 10.6 0.888 2 14.4 0.837 2 21.8 0.943 2 7.2 0.966 2 13.7 1.089 2 0.7 1.155 2 7.9 57 4.56 0 2 632.87329 0.88 37.33 1264.73931

ILAGPAGDSNVVK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.117 1 1.121 1 1.141 1 1.018 1 1.229 1 1.096 1 1.077 1 57 5.11 0 3 761.38116 3.05 68.36 2282.12894

ILASTQFEPTAAR ERAP1 endoplasmic reticulum aminopeptidase 1 isoform b precursor [Homo sapiens]

51752 NP_001035548 2 2 94818891 N-Term(iTRAQ4plex) 1.286 1 0.894 1 1.128 1 1.262 1 1.307 1 1.463 1 1.159 1 4.05 1 3 974.17273 4.97 66.8 2920.50364

ILDDLSPR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

37 2 31542984;262050538

N-Term(iTRAQ4plex) 1.056 29 32.2 0.908 29 21 0.967 28 33 0.977 28 38.7 1.149 29 21.3 1.133 29 25.7 1.122 27 18 108 9.55 0 3 1177.9149 3.93 58.09 3531.71994

ILDVNDNIPVVENK DSG2 desmoglein-2 preproprotein [Homo sapiens]

1829 NP_001934 2 1 116534898 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.929 21 4.3 0.873 21 11.7 0.81 21 7.1 0.922 21 11.2 0.941 21 6.3 1.075 21 7.2 1.128 21 6.6 108 10.01 0 3 840.75494 0.25 57.52 2520.24936

ILEDGSIYTTHDLILSSER DSC1 desmocollin-1 isoform Dsc1b preproprotein [Homo sapiens]

1823 NP_004939 2 2 4826702 N-Term(iTRAQ4plex) 1.052 4 14 0.887 4 24.7 0.83 4 20.8 0.82 4 5.5 1.117 4 20.7 1.328 4 26.7 1.263 4 36.5 102 6.36 0 3 811.05017 -0.28 80.11 2431.13596

ILEGFQPSGR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 4 1 29171717 N-Term(iTRAQ4plex) 0.986 14 14.2 0.923 14 16.3 0.859 14 18 0.999 14 11.2 0.985 14 20.4 1.106 14 9.6 1.134 14 6 87 6.51 0 3 922.52911 -0.6 33.42 1844.06028

ILGDMQPGDYFDLVLFGTR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 21 3 156119625 N-Term(iTRAQ4plex); M5(Oxidation)

1.253 1 1.196 1 1.22 1 1.02 1 1.531 1 1.28 1 1.255 1 61 4.66 0 3 811.05017 -0.28 80.11 2447.14194

ILGDMQPGDYFDLVLFGTR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 68 3 156119625 N-Term(iTRAQ4plex) 0.705 2 0.7 0.842 2 14.7 0.595 2 6 0.707 2 8.6 0.706 2 6 0.838 2 8.6 1.185 2 0.1 58 4.11 0 2 655.8642 1.96 22.96 1310.72112

ILGDPEALR TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex) 1.081 2 3.8 0.927 2 3.9 1.014 2 5.6 1.094 2 9.5 1.068 2 1.5 1.152 2 2.3 1.053 2 7.2 57 5.92 0 3 445.58301 2.83 14.13 1334.73447

ILGEELGFASLHDLQLLGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 112 1 105990532 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.805 1 0.662 1 0.489 1 0.738 1 0.85 1 1.284 1 1.739 1 50 3.98 0 3 648.01813 0.89 50.56 1942.03983

ILGGHLDAK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 2 3 4826762 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.013 4 6.1 0.944 4 6.9 0.872 4 4 0.981 4 8.9 1.018 4 1.6 1.122 4 5.8 1.172 4 3.1 47 3.4 0 2 607.79773 -3.36 22.4 1214.59075

ILGPLSYSK LUM lumican precursor [Homo sapiens] 4060 NP_002336 24 1 4505047 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.893 4 4.5 0.932 4 3.6 0.811 4 9.7 0.904 4 4.1 0.891 4 1.4 0.98 4 7.8 1.123 4 9.3 44 3.59 0 2 584.7951 -3.29 22.8 1168.58464

ILHVFHGLLPGFLVK PCSK9 proprotein convertase subtilisin/kexin type 9 preproprotein [Homo sapiens]

255738 NP_777596 1 1 31317307 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.919 2 1.9 0.968 2 14.2 0.853 2 4 0.881 2 10.2 0.957 2 13.3 0.988 2 0.9 1.122 2 9.3 31 3.51 0 3 629.32941 1.47 18.53 1257.65154

ILIEDWK PRKCSH glucosidase 2 subunit beta isoform 2 precursor [Homo sapiens]

5589 NP_001001329 1 2 48255891 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.037 4 5.6 0.928 4 18.8 1.834 4 14.7 1.923 4 5.5 2.095 4 12.9 2.17 4 4.4 1.142 4 2.3 33 0 2 432.25888 3.25 9.21 863.50975

ILIGTVFHK PON3;PON1 serum paraoxonase/lactonase 3 [Homo sapiens];serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5446;5444 NP_000931;NP_000437

4 2 29788996;19923106

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.765 1 1.075 1 0.755 1 0.703 1 0.832 1 0.774 1 1.101 1 2.78 0 2 615.88019 -13.78 19.55 1230.7531

ILISGLEPSTPYR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 2 188528648 N-Term(iTRAQ4plex) 1.39 1 1 1 1.274 1 1.274 1 1.507 1 1.507 1 1.183 1 49 0 2 601.89142 0.35 49.14 1202.77556

ILLDEQAQWK ICAM2 intercellular adhesion molecule 2 precursor [Homo sapiens]

3384 NP_001093256 7 1 153082686 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.214 1 0.905 1 1.046 1 1.156 1 1.267 1 1.401 1 1.212 1 126 5.6 0 2 899.94281 -0.99 24.84 1798.87834

ILLMDLNEEDPTVLELGITGSK

PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 8 1 19923106 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.216 2 1.9 0.864 2 2.1 1.05 2 4.1 1.215 2 2 1.216 2 1.9 1.407 2 0.3 1.158 2 2.3 47 3.94 0 2 706.36914 0.85 15.37 1411.731

ILLQGTPVAQMTEDAVDAER

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 18 1 115298678 N-Term(iTRAQ4plex); M11(Oxidation)

1.26 2 2.3 0.95 2 11.5 1.221 2 9.9 1.285 2 1.6 1.236 2 3.3 1.301 2 14.8 1.012 2 13.2 47 6.46 0 3 927.80103 1.16 45.66 2781.38669

ILLQGTPVAQMTEDAVDAER

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 41 1 115298678 N-Term(iTRAQ4plex) 1.154 1 0.924 1 1.004 1 1.086 1 1.216 1 1.316 1 1.212 1 44 0 2 602.32629 0.24 27.77 1203.64531

Page 21: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

ILPFQYVLCAATSPAVK TFCP2 alpha-globin transcription factor CP2 isoform 3 [Homo sapiens]

7024 NP_001166924 1 3 291219876 N-Term(iTRAQ4plex); C9(Methylthio); K17(iTRAQ4plex)

1.177 1 0.885 1 1.032 1 1.166 1 1.186 1 1.34 1 1.149 1 37 3.14 0 2 605.31244 -4.65 18.81 1209.6176

ILPLTVCK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 8 1 45580688 N-Term(iTRAQ4plex); C7(Methylthio); K8(iTRAQ4plex)

1.259 1 1.067 1 1.26 1 1.181 1 1.343 1 1.258 1 1.066 1 36 0 2 633.35376 1.77 26.66 1265.70024

ILQLCGELYDLDASSLQLK PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 4 [Homo sapiens]

5138 NP_001230713 1 4 344925852 N-Term(iTRAQ4plex); C5(Methylthio); K19(iTRAQ4plex)

1.226 1 0.789 1 1.053 1 1.336 1 1.14 1 1.446 1 1.082 1 29 2.92 0 2 550.79449 0.02 22.9 1100.58171

ILSGDPYCEK BTD biotinidase precursor [Homo sapiens]

686 NP_000051 18 1 4557373 N-Term(iTRAQ4plex); C8(Methylthio); K10(iTRAQ4plex)

1.509 1 1.1 1 1.394 1 1.268 1 1.775 1 1.614 1 1.273 1 3.81 1 4 873.70099 3.44 50.89 3491.78213

ILSILR CHGA chromogranin-A preproprotein [Homo sapiens]

1113 NP_001266 2 1 4502805 N-Term(iTRAQ4plex) 1.177 1 1.021 1 1.185 1 1.161 1 1.193 1 1.169 1 1.007 1 63 6.32 0 3 682.64777 -0.14 30.77 2045.92875

ILTLPR INSR insulin receptor isoform Short preproprotein [Homo sapiens]

3643 NP_001073285 2 2 119395738 N-Term(iTRAQ4plex) 1.231 1 0.743 1 1.007 1 1.356 1 1.138 1 1.533 1 1.13 1 39 3.13 0 2 674.39618 -1.78 23.62 1347.78508

ILTSDVFQDCNK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 10 1 89191868 N-Term(iTRAQ4plex); C10(Methylthio); K12(iTRAQ4plex)

1.014 1 0.72 1 0.848 1 1.178 1 0.895 1 1.244 1 1.056 1 5.33 0 3 784.75916 6.4 55.08 2352.26291

IMADSGPIYDK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 10 1 40317626 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.499 3 2.2 0.895 3 12.3 1.472 3 22.6 1.536 3 0.8 1.428 3 6.4 1.733 3 6.3 1.128 3 7.2 66 3.82 0 3 814.92719 -0.73 12.97 1628.84745

IMGITLVSK LYVE1 lymphatic vessel endothelial hyaluronic acid receptor 1 precursor [Homo sapiens]

10894 NP_006682 NP_057248

2 1 40549451 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.006 5 5 1.023 5 25.7 1.974 5 9 1.729 5 12.2 2.222 5 8.6 1.986 5 13.3 1.149 5 2.7 64 3.99 0 2 705.91522 -0.26 44.69 1410.82317

IMINFNPHFDLEDR NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 2 5 66864913 N-Term(iTRAQ4plex) 1.415 6 9.5 0.931 6 21.9 1.27 6 10.5 1.329 6 6.7 1.494 6 5.1 1.553 6 15 1.157 6 5.3 64 4.37 0 2 698.85309 2.37 29.64 1396.70012

IMQSSQSMSK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 5 3 21450863 N-Term(iTRAQ4plex); M8(Oxidation); K10(iTRAQ4plex)

1.38 5 14.8 0.832 5 2 1.271 5 5.7 1.505 5 9.1 1.293 5 17.2 1.61 5 11.2 1.142 5 11 62 7.01 0 3 1224.5455 -1.06 37.77 2448.07981

INDVLEHVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.506 4 7.1 0.91 4 1.1 1.341 4 4.2 1.47 4 1.1 1.534 4 9.8 1.686 4 9.5 1.154 4 6.9 61 3.47 0 2 626.83435 -0.74 8.36 1252.66142

INENTGSVSVTR CDH13 cadherin-13 isoform 3 precursor [Homo sapiens]

1012 NP_001207418 6 3 333944018 N-Term(iTRAQ4plex) 0.946 1 1.095 1 0.882 1 0.806 1 1.1 1 1.005 1 1.247 1 55 3.97 0 3 894.12384 -1.35 77.96 2680.35697

INFNEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.523 1 0.707 1 1.172 1 1.657 1 1.429 1 2.02 1 1.219 1 50 6.3 0 3 1224.5455 -1.06 37.77 2464.06986

INHGILYDEEK CFHR1;CFHR2

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 2 precursor [Homo sapiens]

3078;3080 NP_002104;NP_005657

2 2 118442839;5031695

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.22 2 7.1 0.836 2 9.9 1.03 2 0.6 1.231 2 9.4 1.212 2 5.2 1.449 2 15.2 1.177 2 5.8 43 5.97 0 3 625.66443 0.24 45.01 1874.97873

INIPGTPETDIDSSCSR GPR116 probable G-protein coupled receptor 116 precursor [Homo sapiens]

221395 NP_056049 2 1 148719673 N-Term(iTRAQ4plex); C15(Methylthio)

1.554 1 0.853 1 1.367 1 1.603 1 1.513 1 1.774 1 1.107 1 32 0 3 376.88217 3.3 14.28 1128.63196

INLPK KIF13A kinesin-like protein KIF13A isoform d [Homo sapiens]

63971 NP_001099038 1 4 157738629 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

68 6.32 0 3 568.00323 1.22 33.49 1701.98014

INNQLTLDSNTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 20 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.306 1 0.948 1 0.265 1 0.279 1 0.331 1 0.349 1 1.251 1 21 0 2 584.90863 16.42 38.09 1168.80998

INPLALK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 32 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.078 1 0.995 1 1.141 1 1.147 1 1.01 1 1.015 1 0.885 1 67 5.24 0 3 1028.5154 -1.31 32.88 3083.53159

INVGGGLSGDHCK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 8 1 4557389 N-Term(iTRAQ4plex); C12(Methylthio); K13(iTRAQ4plex)

1.377 2 15.5 0.865 2 10.7 1.109 2 22.7 1.282 2 11.7 1.461 2 19.1 1.689 2 8.2 1.318 2 3.5 60 7.2 0 3 795.38666 1.08 41.34 2384.14542

IPCSQPPQIEHGTINSSR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 4 1 62739186 N-Term(iTRAQ4plex); C3(Methylthio)

1.599 1 0.965 1 1.47 1 1.524 1 1.672 1 1.733 1 1.137 1 59 3.85 0 2 679.37817 2.75 20.15 1357.74907

IPDENCQINR GPNMB transmembrane glycoprotein NMB isoform b precursor [Homo sapiens]

10457 NP_002501 3 2 4505405 N-Term(iTRAQ4plex); C6(Methylthio)

1.459 1 1.003 1 1.308 1 1.304 1 1.615 1 1.61 1 1.235 1 44 4.34 0 3 568.98828 -3.56 28.22 1704.95029

IPESGGDNSVFDIFELTGAAR

THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 12 1 40317626 N-Term(iTRAQ4plex) 1.47 1 1.023 1 1.395 1 1.364 1 1.578 1 1.543 1 1.131 1 3.04 0 2 560.83313 -0.5 44.99 1120.65898

IPGIFELGISSQSDR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 36 1 4557391 N-Term(iTRAQ4plex) 1.503 2 3.5 0.981 2 9.4 1.413 2 0.3 1.439 2 9.7 1.566 2 2.4 1.596 2 6.9 1.109 2 2.8 3 0 2 626.34491 -2.3 38.42 1251.68254

IPIEDGSGEVVLSR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 35 1 115298678 N-Term(iTRAQ4plex) 1.403 1 0.822 1 1.282 1 1.56 1 1.274 1 1.55 1 0.994 1 3.69 2 3 790.47382 5.99 71.46 2369.40689

IPLDLVPK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 21 2 38016947 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.075 1 0.917 1 0.964 1 1.05 1 1.098 1 1.197 1 1.14 1 54 3.78 0 2 762.35114 0.5 12.26 1523.69499

IPLVTNEECQK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 2 1 4503627 N-Term(iTRAQ4plex); C9(Methylthio); K11(iTRAQ4plex)

1.072 1 1.278 1 1.049 1 0.821 1 1.393 1 1.09 1 1.328 1 49 4.72 0 3 658.05835 -0.24 76.39 1972.1605

IPSNPSHR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 1 1 86788015 N-Term(iTRAQ4plex) 1.197 1 0.933 1 1.203 1 1.29 1 1.11 1 1.19 1 0.922 1 46 5.99 0 3 674.37158 -2.81 22.88 2021.10019

IPSVQINFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 20 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.309 1 1.125 1 1.325 1 1.178 1 1.457 1 1.295 1 1.099 1 39 0 2 502.814 -2.32 15.66 1004.62071

IPVQLVFK CD109 CD109 antigen isoform 3 precursor [Homo sapiens]

135228 NP_001153060 2 3 227430303 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

3.343 1 0.846 1 2.9 1 3.426 1 3.273 1 3.868 1 1.129 1 27 0 2 409.27298 0.13 10.61 817.53868

IPVVPHNECSEVMSNMVSENMLCAGILGDR

PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 6 1 4506115 N-Term(iTRAQ4plex); C9(Methylthio); C23(Methylthio)

1.117 2 5 1.222 2 8.4 1.177 2 24.3 0.963 2 15.6 1.295 2 3.4 1.06 2 11.8 1.1 2 27.8 3.92 0 4 778.64777 14.23 56.36 3111.56923

IPYSFFK QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 2 13325075 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.639 1 0.985 1 1.686 1 1.713 1 1.566 1 1.59 1 0.928 1 3.63 1 3 949.49347 -16.88 41.96 2846.46585

IPYYNIHPMPVHLQQR H6PD GDH/6PGL endoplasmic bifunctional protein precursor [Homo sapiens]

9563 NP_004276 1 1 52145310 N-Term(iTRAQ4plex) 1.388 4 7.9 1.028 4 16.2 1.345 4 14.9 1.318 4 0.5 1.484 4 18.3 1.464 4 5.6 1.128 4 3.2 75 5.53 0 2 775.95313 -2.76 37.9 1550.89751

IQALQQQADEAEDR TPM4 tropomyosin alpha-4 chain isoform 2 [Homo sapiens]

7171 NP_003281 1 1 4507651 N-Term(iTRAQ4plex) 2.216 2 7.9 0.997 2 11.3 2.071 2 14.3 2.077 2 2.9 2.357 2 13 2.364 2 1.7 1.138 2 1.3 71 4.51 0 2 761.97498 -1.35 44.21 1522.94353

IQALSLCSDQQSHLEFR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 28 1 192447438 N-Term(iTRAQ4plex); C7(Methylthio)

1.32 3 4.7 0.891 3 20 1.217 3 4.5 1.272 3 9.3 1.358 3 9.9 1.525 3 5.4 1.157 3 5.4 68 5.15 0 2 977.01068 1.62 41.08 1953.00517

IQCAAGYEQSEHNVCQDIDECTAGTHNCR

EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C3(Methylthio); C15(Methylthio); C21(Methylthio); C28(Methylthio)

1.368 2 11 0.914 2 13.3 1.234 2 16.4 1.351 2 3.1 1.386 2 18.3 1.517 2 4.9 1.123 2 1.8 47 3.4 0 2 592.8786 1.31 45.34 1184.74785

IQCVDGEWTTLPTCVEQVK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 4 1 13540563 N-Term(iTRAQ4plex); C3(Methylthio); C14(Methylthio); K19(iTRAQ4plex)

1.206 1 0.842 1 1.125 1 1.337 1 1.097 1 1.303 1 0.975 1 46 7.62 1 3 928.12201 -2.17 27.57 2782.35147

IQDALCALESSQALEPK SNX19 sorting nexin-19 [Homo sapiens] 399979 NP_055573 XP_374949

2 1 157502171 N-Term(iTRAQ4plex); C6(Methylthio); K17(iTRAQ4plex)

1.477 1 0.993 1 1.391 1 1.401 1 1.554 1 1.565 1 1.117 1 36 3.56 0 2 558.83258 7.62 35.77 1116.65788

IQFGTLSDFFDALDK MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 1 1 51477714 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.96 1 1.05 1 0.888 1 0.846 1 1.079 1 1.028 1 1.215 1 35 4.89 1 3 568.96271 -1.67 16.27 1704.87357

IQHTVTASVR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex) 1.407 1 0.852 1 1.167 1 1.369 1 1.44 1 1.69 1 1.235 1 3.49 0 3 719.07703 12.39 36.86 2155.21653

IQLVEEELDR TPM4 tropomyosin alpha-4 chain isoform 2 [Homo sapiens]

7171 NP_003281 2 16 4507651 N-Term(iTRAQ4plex) 0.998 5 20.8 0.779 5 16.3 0.789 5 19.4 1.188 5 9.9 0.863 5 15.1 1.117 5 18.9 1.094 5 4.3 115 6.48 0 3 1043.5479 0.26 52.06 2086.09146

IQNILTEEPK PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 17 1 19923106 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.991 10 7.3 0.807 10 27.3 0.866 10 20.5 1.032 10 34.6 1.063 10 16.4 1.189 10 19.4 1.126 10 14 103 9.23 0 3 942.82214 1.88 65.94 2826.44986

IQPSGGTNINEALLR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 66 1 70778918 N-Term(iTRAQ4plex) 0.926 5 9.4 0.909 5 11.1 0.833 5 13.8 0.902 5 16.1 0.999 5 10.1 1.079 5 8.2 1.139 5 7.8 99 4.98 0 2 802.422 -2.59 39.73 1603.83379

IQRPNTTQEGEEMETDMDGVQCIPQR

HUWE1 E3 ubiquitin-protein ligase HUWE1 [Homo sapiens]

10075 NP_113584 NP_005694 NP_060097 XP 497119

1 1 61676188 N-Term(iTRAQ4plex); M17(Oxidation); C22(Methylthio)

0.992 5 8.9 0.906 5 16.6 0.86 5 19.1 0.88 5 13.8 1.075 5 8.4 1.148 5 13 1.182 5 10.6 94 5.67 0 3 900.48798 -5.31 36.91 1799.97361

IQTHSTTYR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 2 1 110611237 N-Term(iTRAQ4plex) 1.047 4 16.4 1.075 4 5.8 0.983 4 10.9 0.897 4 14.2 1.213 4 17.8 1.107 4 21.2 1.179 4 6.3 85 5.07 0 3 947.03217 -0.08 44.37 1893.05765

IQVDYDGHCK FSTL1 follistatin-related protein 1 precursor [Homo sapiens]

11167 NP_009016 2 1 5901956 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

0.413 2 9.7 1.227 2 10.6 0.438 2 1.9 0.357 2 12.6 0.482 2 5.6 0.393 2 16.3 1.101 2 3.6 82 5.36 0 2 792.9317 -6.13 21.24 1584.85613

IQVQTEQ ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 2 21450863 N-Term(iTRAQ4plex) 0.806 7 15.9 0.937 7 7.3 0.728 7 14.9 0.803 7 15.3 0.889 7 12.6 0.895 7 12.3 1.128 7 4.1 73 6.22 0 3 857.98706 -3.08 29.69 1714.96927

IQYQLVDISQDNALR SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 [Homo sapiens]

83442 NP_112576 1 1 13775198 N-Term(iTRAQ4plex) 1.225 4 3.9 1.019 4 6.1 1.159 4 4.2 1.157 4 6.3 1.31 4 2.9 1.32 4 5.9 1.136 4 0.6 71 3.96 0 2 732.39258 0.38 31.81 1463.77788

IQYQLVDISQDNALRDEMR SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 [Homo sapiens]

83442 NP_112576 1 1 13775198 N-Term(iTRAQ4plex) 1.188 2 13.5 0.975 2 9.5 1.093 2 23 1.122 2 13.3 1.253 2 14.1 1.285 2 4.6 1.146 2 8.7 70 4.29 0 2 792.9317 -6.13 21.24 1600.85076

IQYYCHEPYYK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

12 1 66347875 N-Term(iTRAQ4plex); C5(Methylthio); K11(iTRAQ4plex)

0.89 4 5.1 0.978 4 10.8 0.847 4 8.6 0.853 4 2.2 0.914 4 9.6 0.908 4 13.9 1.055 4 13.1 70 4.85 0 2 782.92548 -0.96 36.28 1564.84368

IREEGTDLEVTANR PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 6 1 162809334 N-Term(iTRAQ4plex) 1.144 4 37.3 0.847 4 8.1 1 4 33.3 1.17 4 41.6 1.122 4 33.8 1.312 4 42.1 1.127 4 1.2 68 4.81 0 3 1260.698 1.85 57.08 2520.38156

ISASAEELR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 8 1 71773110 N-Term(iTRAQ4plex) 2.203 2 14.9 1.005 2 13 2.059 2 4.2 2.05 2 17.3 2.359 2 12 2.348 2 25.3 1.145 2 7.7 62 6.39 0 3 839.41968 1.35 68.01 2516.24448

ISCPEGTNAYR REG1B lithostathine-1-beta precursor [Homo sapiens]

5968 NP_006498 2 2 10835248 N-Term(iTRAQ4plex); C3(Methylthio)

0.985 8 18 1.094 8 35 0.872 8 10 0.875 8 33.2 1.133 8 28.9 0.998 8 45.5 1.36 8 43.5 61 7.74 0 4 1127.2108 1.9 72.66 3379.61147

ISCTIANR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

8 6 47132549;16933542

N-Term(iTRAQ4plex); C3(Methylthio)

1.078 2 2.6 1 2 4.3 0.959 2 2.5 0.96 2 6.8 1.197 2 1.1 1.198 2 3.2 1.248 2 3.7 61 4.24 0 2 751.95782 -6.75 39.41 1502.90837

ISEENETTCYMGK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 2 1 62739186 N-Term(iTRAQ4plex); C9(Methylthio); K13(iTRAQ4plex)

1.275 1 1.009 1 0.976 1 0.968 1 1.585 1 1.571 1 1.623 1 60 6.49 0 3 1208.9793 5.26 66.13 3624.92319

ISEGLPALEFPNEK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 2 1 4502511 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.041 3 5.6 1.14 3 15.7 1.222 3 18.4 1.053 3 21.1 1.167 3 19 1.002 3 26 0.955 3 0.5 54 7.38 1 3 1005.2122 -0.56 49.95 3013.6221

ISEITNIVSK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 6 1 162809334 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.235 1 0.946 1 1.23 1 1.3 1 1.173 1 1.24 1 0.954 1 53 5.14 0 3 839.41968 1.35 68.01 2500.24948

ISETSLPPDMYECLR LUM lumican precursor [Homo sapiens] 4060 NP_002336 37 1 4505047 N-Term(iTRAQ4plex); C13(Methylthio)

0.943 5 2.7 1.038 5 4.2 0.894 5 3 0.876 5 3.6 1.027 5 3.7 1.016 5 3.9 1.148 5 1.5 51 3.54 0 2 762.37317 -5.66 27.2 1523.7448

ISETSLPPDMYECLR LUM lumican precursor [Homo sapiens] 4060 NP_002336 1 1 4505047 N-Term(iTRAQ4plex); M10(Oxidation); C13(Methylthio)

0.787 1 0.798 1 0.651 1 0.815 1 0.765 1 0.958 1 1.175 1 49 3.53 0 2 619.86426 -1.82 26.13 1238.72124

ISFDEFIK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 6 1 167614506 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.832 3 7.9 0.908 3 23.8 0.712 3 19.6 0.827 3 6.6 0.875 3 21.2 0.973 3 1.6 1.215 3 1.6 47 3.8 0 2 562.33392 1.21 23.65 1123.65886

ISISTSGGSFR KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 6 1 119395754 N-Term(iTRAQ4plex) 0.903 2 9.7 1.025 2 5.5 0.861 2 17.6 0.841 2 12 0.967 2 8 0.944 2 2.5 1.123 2 9.5 42 3.29 0 2 624.34357 -5.33 37.48 1247.67986

ISLGPR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex) 0.907 5 0.9 0.87 5 4.7 0.831 5 9.2 0.916 5 6.3 0.936 5 1.5 1.048 5 10.8 1.144 5 1.9 35 3.51 0 2 536.32281 -0.75 15.24 1071.6364

ISLPESLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 35 1 115298678 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.162 1 0.941 1 1.066 1 1.133 1 1.189 1 1.264 1 1.116 1 4.29 2 4 715.3703 2.78 44.53 2858.45937

ISLSPEYVFSVSTFR COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 2 5 55743098 N-Term(iTRAQ4plex) 1.464 2 11.5 0.913 2 8.5 1.305 2 9.9 1.429 2 18.5 1.497 2 5.3 1.64 2 13.8 1.147 2 4.6 84 5.42 0 2 753.38635 -1.5 28.61 1505.76872

ISMLEK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 1 1 4503635 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.166 1 0.95 1 1.062 1 1.118 1 1.213 1 1.276 1 1.142 1 98 5.37 0 2 966.06708 -1.82 58.37 1931.12688

ISNIIK RRAGA ras-related GTP-binding protein A [Homo sapiens]

10670 NP_006561 3 3 5729999 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.012 1 1.017 1 0.95 1 0.935 1 1.091 1 1.073 1 1.148 1 67 6.21 0 3 789.73071 4.61 35.48 2367.17759

ISNIPDEYFK LUM lumican precursor [Homo sapiens] 4060 NP_002336 25 1 4505047 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.112 3 10.3 0.939 3 0.4 1.004 3 3.5 1.06 3 1.7 1.175 3 23.5 1.251 3 17.7 1.199 3 15.3 88 5.03 0 3 762.29547 -2.53 57.61 2284.87186

ISSVLAGGSCR KRT16;KRT14

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens]

3868;3861 NP_005548;NP_000517

1 2 24430192;15431310

N-Term(iTRAQ4plex); C10(Methylthio)

1.248 7 5.7 1.069 7 3.9 1.235 7 5.2 1.165 7 3.9 1.369 7 6.9 1.355 7 7.4 1.119 7 1 80 3.98 0 2 637.88623 7.31 17.54 1274.75688

ISVAQGASK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.234 4 9 1.022 4 17.8 1.158 4 22.5 1.176 4 12.5 1.249 4 21.7 1.276 4 10.3 1.085 4 3.9 74 2.88 0 2 629.31464 0.77 30.64 1257.622

ISVIRPSK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 3 1 67782358 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.206 6 10.8 0.738 6 28.2 0.971 6 30.3 1.34 6 13.8 1.158 6 16.1 1.498 6 19.1 1.09 6 7.3 67 8.4 0 3 1044.4784 0.65 49.22 3131.42466

ITCAEEGWSPTPK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 25 1 5031695 N-Term(iTRAQ4plex); C3(Methylthio); K13(iTRAQ4plex)

1.477 2 2.6 0.915 2 5.9 1.327 2 5 1.451 2 0.9 1.502 2 5.8 1.642 2 0.1 1.132 2 0.8 66 5.23 0 3 555.98682 2.67 22.04 1665.9459

ITCPNVDGYFPSSVKPTITWYMGCYK

IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 2 3 19882209 N-Term(iTRAQ4plex); C3(Methylthio); K15(iTRAQ4plex); C24(Methylthio); K26(iTRAQ4plex)

1.062 5 12.1 0.967 5 7.2 1.004 5 10.2 1.067 5 12.1 1.123 5 8.9 1.205 5 10.7 1.119 5 1.3 63 5.62 0 4 1021.0158 -0.28 32.06 2041.03115

ITCTEEGWSPTPK CFHR1;CFHR5

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 5 precursor [Homo sapiens]

3078;81494

NP_002104;NP_110414

31 2 118442839;13540563

N-Term(iTRAQ4plex); C3(Methylthio); K13(iTRAQ4plex)

1.029 2 35.9 1.007 2 3.9 0.933 2 46.3 0.927 2 50.9 1.128 2 23.9 1.12 2 28 1.209 2 20.8 59 5.57 0 3 625.67462 -5.32 17.12 1875.00931

ITDLIK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 41 1 50659080 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.054 12 4.6 0.953 12 11 0.962 12 9 1.02 12 10.3 1.104 12 10.7 1.173 12 12.1 1.119 12 4.7 57 4.96 0 2 858.4184 -4.13 26.64 1715.82854

ITDNMFCAGYKPDEGK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 8 1 4503635 N-Term(iTRAQ4plex); M5(Oxidation); C7(Methylthio); K11(iTRAQ4plex); K16(iTRAQ4plex)

0.917 7 23.2 1.014 7 1.9 0.947 7 15.6 0.926 7 12.3 0.933 7 29.9 1.024 7 11.7 1.101 7 3.3 51 4.22 0 2 770.33911 0.16 39.63 1539.66704

ITDNMFCAGYKPDEGK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 14 1 4503635 N-Term(iTRAQ4plex); C7(Methylthio); K11(iTRAQ4plex); K16(iTRAQ4plex)

1.135 2 4.5 1.005 2 10.4 1.087 2 10.8 1.081 2 0.4 1.191 2 8.6 1.184 2 1.7 1.095 2 2.2 45 3.94 0 2 647.84155 2.31 44.74 1294.67583

ITDNMFCAGYKPDEGKR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 5 1 4503635 N-Term(iTRAQ4plex); M5(Oxidation); C7(Methylthio); K11(iTRAQ4plex); K16(iTRAQ4plex)

1.282 2 0.1 1.218 2 16.5 1.379 2 10.2 1.132 2 6.2 1.469 2 8 1.206 2 8.4 1.065 2 2.2 41 0 2 513.76819 -2.3 12.14 1026.5291

ITDNMFCAGYKPDEGKR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 6 1 4503635 N-Term(iTRAQ4plex); C7(Methylthio); K11(iTRAQ4plex); K16(iTRAQ4plex)

1.16 2 8.7 0.971 2 6.7 1.066 2 7.9 1.098 2 14.7 1.221 2 3.2 1.257 2 9.9 1.145 2 4.7 35 4.4 1 3 812.92139 2.02 13.89 1624.8355

ITEATK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

13 3 4504893;156231037

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.678 4 10.5 1.027 4 9.7 1.542 4 21.8 1.626 4 3.6 1.75 4 19.6 1.819 4 5.1 1.131 4 1.6 33 0 2 554.84039 -2.02 40.36 1108.67351

ITENDIQIALDDAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 37 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.077 1 0.872 1 0.935 1 1.072 1 1.081 1 1.24 1 1.156 1 6.06 1 3 872.46082 8.49 20.97 2615.36789

ITEVALMGHLSCDTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 13 1 105990532 N-Term(iTRAQ4plex); C12(Methylthio); K15(iTRAQ4plex)

1.402 1 0.952 1 1.341 1 1.409 1 1.396 1 1.467 1 1.041 1 5 0 3 479.621 1.43 13.48 1436.84845

ITEVALMGHLSCDTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 13 1 105990532 N-Term(iTRAQ4plex); M7(Oxidation); C12(Methylthio); K15(iTRAQ4plex)

0.948 1 0.943 1 0.838 1 0.888 1 1.003 1 1.064 1 1.198 1 30 0 2 473.29657 0.93 39.03 945.58586

ITFELVYEELLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

232 2 31542984;262050538

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.038 2 3.2 0.85 2 26.3 0.957 2 5.2 1.126 2 20.9 0.97 2 12.2 1.141 2 13.8 1.013 2 7 36 1 2 839.98322 -16.06 58.19 1678.95452

ITGKPIK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 2 1 39725934 N-Term(iTRAQ4plex); K4(iTRAQ4plex); K7(iTRAQ4plex)

1.027 1 0.844 1 1.075 1 1.275 1 0.817 1 0.969 1 0.76 1 4.27 0 4 684.63293 -2.36 69.89 2735.50991

ITGTMPPLPLEATGLALSSLR

CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 8 1 4557417 N-Term(iTRAQ4plex) 1.374 1 0.968 1 1.3 1 1.342 1 1.405 1 1.451 1 1.081 1 60 5.8 0 3 647.03345 -1.26 40.81 1939.08579

ITGYIIK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

12 5 47132549;16933542

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.745 1 0.87 1 0.644 1 0.74 1 0.748 1 0.86 1 1.162 1 83 2.85 0 2 693.89417 -4.39 22.77 1386.78105

ITHYNYLILSK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 12 2 38016947 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.477 2 32.6 0.84 2 2.2 1.185 2 30.7 1.411 2 28.4 1.532 2 36 1.824 2 33.7 1.292 2 4.9 4.46 0 4 859.95325 0.85 68.07 3436.79116

ITILR PPP2CA serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [Homo sapiens]

5515 NP_002706 1 2 4506017 N-Term(iTRAQ4plex) 54 5.15 0 3 439.2807 -4.94 27.63 1315.82755

ITITNDQNR HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 2 1 16507237 N-Term(iTRAQ4plex) 0.783 2 6.2 0.807 2 15.4 0.651 2 3.9 0.807 2 11.5 0.765 2 2.2 0.949 2 17.6 1.176 2 6.1 82 4.79 0 3 1103.9612 2.85 67.24 2206.91526

ITKPALLVLNHETAK CETP cholesteryl ester transfer protein precursor [Homo sapiens]

1071 NP_000069 1 1 169636439 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K15(iTRAQ4plex)

1.102 8 8.2 1.053 8 10.3 1.064 8 13.4 1.035 8 13.9 1.193 8 13.3 1.19 8 14.7 1.141 8 4.4 58 3.89 0 2 734.83698 -1.63 27.8 1468.66667

ITLIINWLQEALSSASLAHMK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 21 1 105990532 N-Term(iTRAQ4plex); M20(Oxidation); K21(iTRAQ4plex)

0.898 1 1.077 1 0.855 1 0.794 1 1.01 1 0.938 1 1.18 1 38 0 2 506.79318 1.72 23.52 1012.57909

ITLLLMASQEPQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex) 1.04 1 0.895 1 0.912 1 1.02 1 1.059 1 1.183 1 1.16 1 34 0 2 421.25424 -0.06 19.42 841.50121

ITLLSALVETR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 290 1 50659080 N-Term(iTRAQ4plex) 0.919 1 0.839 1 0.778 1 0.927 1 0.912 1 1.086 1 1.171 1 23 3.25 0 2 622.76941 -8.51 20.3 1244.53154

ITLLSALVETRTIVR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 1 1 50659080 N-Term(iTRAQ4plex) 1.107 1 0.908 1 1.008 1 1.11 1 1.103 1 1.215 1 1.095 1 74 4.1 0 2 732.90149 1.99 27.28 1464.7957

ITLPDFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex) 1.556 2 0.2 1.02 2 15.3 1.496 2 7.8 1.467 2 7.5 1.651 2 8.1 1.618 2 7.2 1.103 2 0.3 2.9 0 2 732.42139 15.32 32.96 1463.8355

ITLPDFTGDLR LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 8 1 31652249 N-Term(iTRAQ4plex) 1.085 1 0.848 1 0.91 1 1.073 1 1.095 1 1.29 1 1.203 1 4.56 1 4 781.66919 -13.15 50.87 3123.65493

ITPGKPYILTVPGHLDEMQLDIQAR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

13 6 178557739;67190748

N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.317 1 0.84 1 1.104 1 1.315 1 1.319 1 1.571 1 1.195 1 3.82 2 4 830.68811 -9.34 49.26 3319.73061

ITPGKPYILTVPGHLDEMQLDIQAR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

1 6 178557739;67190748

N-Term(iTRAQ4plex); K5(iTRAQ4plex); M18(Oxidation)

1.199 1 1.115 1 1.199 1 1.075 1 1.337 1 1.199 1 1.115 1 66 3.92 0 2 637.40161 -0.83 32.57 1273.79595

ITPNLAEFAFSLYR SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 4 1 189163538 N-Term(iTRAQ4plex) 1.436 1 0.85 1 1.181 1 1.389 1 1.475 1 1.735 1 1.249 1 43 5.47 0 3 747.39789 -2.28 54.15 2240.17911

ITPSYVAFTPEGER HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 8 1 16507237 N-Term(iTRAQ4plex) 0.968 1 1.053 1 0.889 1 0.845 1 1.098 1 1.043 1 1.234 1 39 3.63 0 2 628.84406 -1.58 21.22 1256.68083

ITQDAQLK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 4 1 73858564 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.461 1 0.935 1 1.307 1 1.398 1 1.52 1 1.626 1 1.163 1 51 5.14 0 2 954.48047 3.15 44.01 1907.95366

ITQRIYEMEVSALEK C5orf52 uncharacterized protein C5orf52 [Homo sapiens]

100190949 NP_001138604 1 1 223468665 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.232 1 0.856 1 1.022 1 1.194 1 1.264 1 1.477 1 1.237 1 4.97 0 3 718.05438 5.08 27.18 2152.14859

Page 22: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

ITQVLHFTK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

22 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.137 1 0.418 1 0.826 1 1.975 1 0.786 1 1.879 1 0.952 1 4.88 1 4 683.36652 0.67 15.4 2730.44423

ITTGGDVINNGLWNMVSVEELEHSISIK

PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 33 1 192447438 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.524 1 1.029 1 1.406 1 1.366 1 1.687 1 1.639 1 1.2 1 4.95 1 5 853.41895 4.95 58.58 4263.06562

ITTGGDVINNGLWNMVSVEELEHSISIK

PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 6 1 192447438 N-Term(iTRAQ4plex); M15(Oxidation); K28(iTRAQ4plex)

1.538 1 1.086 1 1.657 1 1.527 1 1.55 1 1.428 1 0.935 1 5.46 1 3 883.76855 -12.85 57.7 2649.29111

ITTTSPWMFPSR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 4 1 4557892 N-Term(iTRAQ4plex) 1.383 2 0.4 0.933 2 8.7 1.269 2 5.5 1.36 2 3.2 1.405 2 2.3 1.505 2 6.3 1.107 2 3.1 2.81 2 2 1055.1024 1.95 30.28 2109.19756

ITTTSPWMFPSR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 3 1 4557892 N-Term(iTRAQ4plex); M8(Oxidation)

0.996 1 0.886 1 0.896 1 1.011 1 0.983 1 1.11 1 1.098 1 90 4.84 0 2 719.91974 1.76 17.65 1438.8322

ITTVAHTEVGPGPESSPVVVR

PTPRS receptor-type tyrosine-protein phosphatase S isoform 2 precursor [Homo sapiens]

5802 NP_570924 2 2 104487297 N-Term(iTRAQ4plex) 0.236 2 10.6 1.09 2 10.6 0.237 2 13.3 0.218 2 2.6 0.256 2 18.9 0.235 2 8.1 1.081 2 5.5 88 4.12 0 3 820.44086 -2.81 38.53 1639.8801

ITVVAGEHNIEETEHTEQK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 6 1 4503649 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.164 3 8.6 0.913 3 1 1.043 3 4.2 1.142 3 0.7 1.184 3 15.8 1.297 3 6.5 1.136 3 5.9 83 4.77 0 2 806.93768 -0.04 66.27 1612.86809

ITVVDALHEIPVK IGFBP7 insulin-like growth factor-binding protein 7 isoform 2 precursor [Homo sapiens]

3490 NP_001240764 4 2 359465608 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.165 1 1.053 1 1.099 1 1.044 1 1.292 1 1.227 1 1.176 1 81 5.34 0 2 763.41309 5.78 19.31 1525.8189

ITYGETGGNSPVQEFTVPGSK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

14 5 47132549;16933542

N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.113 2 16 1.026 2 0.9 1.035 2 15.5 1.008 2 14.6 1.221 2 17.2 1.189 2 16.3 1.18 2 1.7 79 5.74 0 2 913.02661 -0.15 54.89 1825.04595

ITYYHLSFPTNIQAPAVVFR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 12 1 34734062 N-Term(iTRAQ4plex) 1.083 1 1.109 1 1.08 1 0.973 1 1.204 1 1.085 1 1.115 1 66 3.6 0 2 742.40784 -4.3 25.31 1483.8084

IVACASYKPSR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 5 2 38016947 N-Term(iTRAQ4plex); C4(Methylthio); K8(iTRAQ4plex)

1.208 1 0.76 1 1.099 1 1.446 1 1.026 1 1.35 1 0.934 1 63 4.14 0 3 698.34015 -1.97 44.5 2093.00589

IVAISEDYPR DSG2 desmoglein-2 preproprotein [Homo sapiens]

1829 NP_001934 2 1 116534898 N-Term(iTRAQ4plex) 1.033 1 1.102 1 0.944 1 0.857 1 1.227 1 1.113 1 1.299 1 58 4.59 0 2 902.91473 -0.06 80.27 1804.82219

IVDLIK GSTT1 glutathione S-transferase theta-1 [Homo sapiens]

2952 NP_000844 1 1 167466164 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.046 1 0.87 1 1.052 1 1.21 1 0.903 1 1.038 1 0.858 1 56 5.86 0 3 583.2912 0.12 64.54 1747.85904

IVDLVK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 3 1 189163538 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.155 1 0.918 1 1.035 1 1.127 1 1.181 1 1.287 1 1.141 1 56 4.24 0 2 856.91418 -0.36 47.79 1712.82109

IVDLVSELK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 7 1 21361302 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.786 1 0.927 1 0.711 1 0.767 1 0.804 1 0.867 1 1.13 1 49 4.13 0 2 802.94641 -1.36 19.08 1604.88555

IVDLVSELKK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 2 1 21361302 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K10(iTRAQ4plex)

0.231 3 35.7 0.989 3 8.5 0.2 3 34.3 0.239 3 42.8 0.224 3 14.4 0.268 3 40.1 1.119 3 2.4 41 3.52 0 2 621.30719 -0.03 22.58 1241.6082

IVEGSDAEIGMSPWQVMLFR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 2 1 4503635 N-Term(iTRAQ4plex); M11(Oxidation); M17(Oxidation)

1.075 1 1.144 1 1.158 1 1.012 1 1.146 1 1.002 1 0.99 1 40 2.82 0 2 1116.598 4.75 67.71 2232.18877

IVEGSDAEIGMSPWQVMLFR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 19 1 4503635 N-Term(iTRAQ4plex) 1.206 1 1.037 1 1.15 1 1.109 1 1.306 1 1.26 1 1.136 1 35 3.59 0 2 637.35468 -0.06 63.05 1273.70207

IVEGSDAEIGMSPWQVMLFR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 9 1 4503635 N-Term(iTRAQ4plex); M11(Oxidation)

1.147 4 6.8 0.939 4 8.1 1.003 4 2.7 1.03 4 16.9 1.207 4 13.9 1.378 4 24.7 1.186 4 11.7 31 7.08 1 3 1089.1497 2.25 64.96 3265.42856

IVFPHGITLDLVSR LRP1 prolow-density lipoprotein receptor-related protein 1 precursor [Homo sapiens]

4035 NP_002323 2 1 126012562 N-Term(iTRAQ4plex) 1.267 1 0.953 1 1.118 1 1.172 1 1.357 1 1.423 1 1.214 1 3.47 1 3 651.04919 -0.36 26.23 1951.13303

IVGGQECK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 3 1 4503625 N-Term(iTRAQ4plex); C7(Methylthio); K8(iTRAQ4plex)

1.193 1 0.945 1 1.136 1 1.202 1 1.185 1 1.255 1 1.044 1 2.85 0 2 498.76886 7.35 25.85 996.53044

IVGGTASVR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 6 1 4503627 N-Term(iTRAQ4plex) 1.167 1 0.891 1 0.999 1 1.121 1 1.208 1 1.356 1 1.21 1 27 0 3 415.53815 5.72 16.86 1244.59989

IVGNSGLNIYNLYAPCAGGVPSHFR

CTSA lysosomal protective protein isoform b precursor [Homo sapiens]

5476 NP_001121167 2 3 189163485 N-Term(iTRAQ4plex); C16(Methylthio)

1.292 1 1.004 1 1.266 1 1.261 1 1.324 1 1.318 1 1.046 1 3.87 2 4 933.4754 -18.14 55.93 3730.87978

IVIEYVDR CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 6 1 119392081 N-Term(iTRAQ4plex) 1.786 1 1.062 1 1.686 1 1.588 1 1.997 1 1.88 1 1.184 1 2.8 0 2 712.41663 -1.9 38.75 1423.82598

IVLGQEQDSYGGK APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 69 1 4502133 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.47 1 0.993 1 1.38 1 1.389 1 1.55 1 1.561 1 1.123 1 90 4.74 0 2 991.46729 -1.08 39.93 1981.92729

IVLLDVPVR ITGA2B integrin alpha-IIb preproprotein [Homo sapiens]

3674 NP_000410 1 1 88758615 N-Term(iTRAQ4plex) 1.154 1 0.927 1 1.155 1 1.246 1 1.068 1 1.153 1 0.925 1 4.23 0 4 495.31061 -1.97 48.42 1978.2206

IVQILPWEQNEQVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.797 2 3.5 1.121 2 7.1 1.796 2 10 1.602 2 17.1 2.008 2 9.3 1.791 2 2.2 1.118 2 19.4 85 5.01 0 3 842.37988 -0.83 17.56 1683.75309

IVQLIQDTR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 8 1 4503011 N-Term(iTRAQ4plex) 0.837 2 7.5 0.92 2 13.4 0.737 2 0.8 0.801 2 14.2 0.864 2 26.8 0.94 2 13 1.173 2 27.6 53 5.14 1 3 997.1861 1.31 57.06 2989.54374

IVSSAMEPDR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 5 2 62739186 N-Term(iTRAQ4plex); M6(Oxidation)

1.405 1 0.843 1 1.222 1 1.45 1 1.367 1 1.622 1 1.119 1 52 3.89 0 2 550.81171 -1.78 15.43 1100.61614

IVSSAMEPDR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 7 2 62739186 N-Term(iTRAQ4plex) 1.873 2 5.1 0.918 2 7.6 1.711 2 2.7 1.863 2 10.3 1.884 2 0.4 2.052 2 8 1.101 2 2.3 52 0 2 646.82477 2.84 24.46 1292.64226

IVSSAMEPDREYHFGQAVR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 25 2 62739186 N-Term(iTRAQ4plex) 66 3.94 0 2 847.9165 -2.26 74.08 1694.82573

IVSSAMEPDREYHFGQAVR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 13 2 62739186 N-Term(iTRAQ4plex); M6(Oxidation)

1.001 1 0.939 1 0.882 1 0.939 1 1.06 1 1.129 1 1.202 1 61 0 2 729.88763 0.71 27.89 1458.76799

IVVEEK TTN titin isoform N2-A [Homo sapiens] 7273 NP_596869 1 2 291045225 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.222 1 1.031 1 1.215 1 1.178 1 1.266 1 1.228 1 1.043 1 3.91 1 3 858.76862 -19.18 55.17 2574.29129

IVVVTAGVR LDHB L-lactate dehydrogenase B chain [Homo sapiens]

3945 NP_002291 2 1 4557032 N-Term(iTRAQ4plex) 1.738 1 0.973 1 1.588 1 1.632 1 1.842 1 1.893 1 1.16 1 3.44 1 3 749.03497 -11.53 40.21 2245.09037

IWDVVEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 28 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.265 1 0.957 1 2.091 1 2.185 1 2.342 1 2.447 1 1.12 1 32 4.86 0 3 471.2587 3.04 14.41 1411.76154

IWLDNVR CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 2 1 5174411 N-Term(iTRAQ4plex) 131 10.04 0 3 1208.9393 7.68 69.25 3624.79575

IYGKWYNLAIGSTCPWLK AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 3 1 4502067 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C14(Methylthio); K18(iTRAQ4plex)

129 9.96 0 3 1208.9393 7.68 69.25 3608.79563

IYGNQDTSSQLK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 23 1 70778918 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

122 10.43 0 3 1556.7465 -0.83 55.15 3112.48564

IYGPSDSASR PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex) 117 9.87 0 3 1105.9077 3.7 53.24 3315.70859

IYGTTDNLCSR LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 2 2 341915493 N-Term(iTRAQ4plex); C9(Methylthio)

116 9.02 0 3 1035.8834 0.62 80.83 3105.6445

IYHSHIDAPK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 11 1 4557485 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

109 6.98 1 2 999.04578 -9.29 16.27 1997.08428

IYLIVK KIF13A kinesin-like protein KIF13A isoform d [Homo sapiens]

63971 NP_001099038 2 4 157738629 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

107 4.68 0 2 716.91779 2.29 20.69 1432.82378

IYLYTLNDNAR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

23 5 47132549;16933542

N-Term(iTRAQ4plex) 105 6.72 0 2 798.42932 -7.41 18.95 1595.85088

IYMADLESALHYILR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

24 2 13325075 N-Term(iTRAQ4plex) 101 8.79 0 3 913.16602 3.42 64.49 2737.48679

IYMTCPDCPSSIPTDSSNHQVLEAATESLAK

FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 5 1 58331240 N-Term(iTRAQ4plex); C5(Methylthio); C8(Methylthio); K31(iTRAQ4plex)

100 8.99 0 4 1105.9077 3.7 53.24 3331.6937

IYMTCPDCPSSIPTDSSNHQVLEAATESLAK

FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 2 1 58331240 N-Term(iTRAQ4plex); M3(Oxidation); C5(Methylthio); C8(Methylthio); K31(iTRAQ4plex)

96 5.65 0 3 998.02222 -4.44 30.52 1995.04428

IYMYGGK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 3 21450863 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

95 5.87 0 2 786.93555 -1.7 48.33 1572.86565

IYPTVNCQPLGMISLMK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

14 3 4504893;156231037

N-Term(iTRAQ4plex); C7(Methylthio); K17(iTRAQ4plex)

93 6.37 0 3 1019.0378 0.29 27.31 2037.07195

IYPTVNCQPLGMISLMK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

8 3 4504893;156231037

N-Term(iTRAQ4plex); C7(Methylthio); M12(Oxidation); K17(iTRAQ4plex)

92 4.68 0 2 730.43164 -3.47 29.57 1459.86382

IYPTVNCQPLGMISLMK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

4 3 4504893;156231037

N-Term(iTRAQ4plex); C7(Methylthio); M12(Oxidation); M16(Oxidation); K17(iTRAQ4plex)

92 6.33 0 3 978.5293 -0.31 40.05 1956.04985

IYSEVTCFFDHVTHR MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 2 1 51477714 N-Term(iTRAQ4plex); C7(Methylthio)

89 7.73 0 3 1280.1465 1.9 35.16 2559.28672

IYSGILNLSDITK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 7 1 78191798 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

89 6.62 0 5 1164.6069 2.55 27.89 2328.20341

IYSILK TTK dual specificity protein kinase TTK isoform 2 [Homo sapiens]

7272 NP_001160163 20 2 262399361 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

85 5.16 0 3 998.02222 -4.44 30.52 2011.04148

IYSLWEHSTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

85 5.52 0 2 893.01855 0.55 67.52 1785.03191

KAADDTWEPFASGK TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 2 1 4507725 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K14(iTRAQ4plex)

77 4.98 0 2 798.92139 0.3 31.42 1596.83599

KAAISGENAGLVR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 2 1 156119625 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

75 5.11 0 3 1019.0378 0.29 27.31 2053.0629

KADGSYAAWLSR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

18 6 178557739;67190748

K1(iTRAQ4plex); N-Term(iTRAQ4plex)

73 4.81 0 2 755.42963 -4.63 42.44 1509.85869

KAEEEHLGILGPQLHADVGDK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 73 1 4557485 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K21(iTRAQ4plex)

71 7.12 1 3 1359.2799 1.62 72.21 2717.55265

KAFDICPLVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 11 2 38016947 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

71 8.51 0 4 1183.9592 1.41 60.37 3549.86313

KAGTELVNFLSYFVELGTQPATQ

APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 26 1 4502149 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

70 4.36 0 2 583.32855 0.74 13.52 1165.63762

KALYLQYTDETFR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

69 7.63 0 4 1042.5724 -7.07 25.91 2084.14907

KAMAVEDIISR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 4 1 4557389 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

69 3.86 0 2 755.42963 -4.63 42.44 1525.8499

KAQDQDFYLCPIYK DNAH1 dynein heavy chain 1, axonemal [Homo sapiens]

25981 NP_056327 1 1 197927452 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C10(Methylthio); K14(iTRAQ4plex)

68 9.46 1 4 1090.205 3.36 47.42 3268.59731

KATVVYQGER APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 5 1 153266841 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

67 3.87 0 2 611.37482 -1.81 26.5 1221.74333

KCLVNLIEK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 1 1 67782358 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C2(Methylthio); K9(iTRAQ4plex)

65 4.63 0 2 710.90576 -1.91 55.56 1420.80425

KCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 1 1 4505881 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C2(Methylthio); C29(Methylthio); K35(iTRAQ4plex)

64 6.7 1 3 984.56757 -3.79 45.22 1968.13272

KCSYTEDAQCIDGTIEVPK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 8 1 153266841 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio); K19(iTRAQ4plex)

62 6.21 1 3 823.06415 0.97 76.44 2467.17789

KDDIMLDEGMLQSLMELPDQYNYGMYAK

C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 8 1 4557389 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K28(iTRAQ4plex)

57 8.61 0 6 865.25555 -0.38 80.67 5186.49694

KDDIMLDEGMLQSLMELPDQYNYGMYAK

C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 16 1 4557389 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M15(Oxidation); K28(iTRAQ4plex)

55 3.67 0 2 572.33319 -1.04 18.9 1143.66167

KDDIMLDEGMLQSLMELPDQYNYGMYAK

C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 1 1 4557389 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M10(Oxidation); M15(Oxidation); K28(iTRAQ4plex)

54 2.98 0 2 583.32855 0.74 13.52 1181.64299

KDNCPNLPNSGQEDYDK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 1 1 40317626 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); K17(iTRAQ4plex)

52 4.33 0 3 445.95648 4.39 46.2 1335.84746

KDNEQHVFK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 12 1 67782358 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

48 3.51 0 3 410.20984 -0.12 2.25 1228.61496

KDTVIKPLLVEPEGLEK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K6(iTRAQ4plex); K17(iTRAQ4plex)

48 7.39 1 3 984.56757 -3.79 45.22 1984.13376

KEAGIPEFYDYDVALIK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 18 1 67782358 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K17(iTRAQ4plex)

46 3.21 0 2 536.80725 -4.39 23.28 1072.61308

KEDSCQLGYSAGPCMGMTSR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 13 1 4502067 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C5(Methylthio); C14(Methylthio); M15(Oxidation)

43 3.13 0 2 487.77863 -0.01 9.5 974.5504

KEDSCQLGYSAGPCMGMTSR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 8 1 4502067 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C5(Methylthio); C14(Methylthio)

40 4.04 0 3 467.57288 9.91 27.17 1400.70407

KEDSCQLGYSAGPCMGMTSR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 4 1 4502067 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C5(Methylthio); C14(Methylthio); M15(Oxidation); M17(Oxidation)

40 5.44 0 3 818.98596 -6.13 14.23 1636.96671

KEEFHEQSFR HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 3 2 295054188 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

39 0 2 381.71494 -0.09 0.22 762.42259

KELELQIGNALFIGK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 5 1 205277441 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K15(iTRAQ4plex)

39 0 2 431.78418 1.2 11.44 862.56108

KELSSFIDK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 4 2 32483410 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

37 3.46 0 3 581.32892 0.74 11.32 1161.65284

KESCGYDTCYDWEK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 4 1 169636415 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio); K14(iTRAQ4plex)

34 4.66 1 3 497.98761 -1.25 32.64 1491.94828

KEVYIK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 6 1 67782358 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K6(iTRAQ4plex)

32 0 2 457.24118 2.76 11.77 913.47508

KEVYMPSSIFQDDFVIPDISEPGTWK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

K1(iTRAQ4plex); N-Term(iTRAQ4plex); K26(iTRAQ4plex)

28 0 2 406.20743 1.13 10.77 811.40758

KEVYMPSSIFQDDFVIPDISEPGTWK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

K1(iTRAQ4plex); N-Term(iTRAQ4plex); M5(Oxidation); K26(iTRAQ4plex)

3.82 0 3 419.27512 1.51 13.87 1255.81079

KFCKTYIEDLVK LRRC49 leucine-rich repeat-containing protein 49 isoform 3 [Homo sapiens]

54839 NP_001185947 2 3 312222719 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C3(Methylthio); K4(iTRAQ4plex); K12(iTRAQ4plex)

2.521 2 5.8 0.917 2 12.1 2.27 2 13.5 2.477 2 1.3 2.566 2 9.9 2.799 2 2.2 1.13 2 3.5 2.93 0 2 775.94177 6.06 39.99 1550.87627

KFICPLTGLWPINTLK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 155 1 153266841 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); K16(iTRAQ4plex)

0.877 1 0.977 1 0.809 1 0.827 1 0.925 1 0.947 1 1.144 1 85 5.24 0 2 1057.4672 4.5 34.2 2113.92705

KFPSGTFEQVSQLVK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 144 2 32483410 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.933 1 0.711 1 0.825 1 1.16 1 0.772 1 1.086 1 0.936 1 49 7.81 1 4 763.85175 0.2 58.21 3052.38515

KFSEWGNNAFFYYFEHR BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 2 1 4557351 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

0.592 1 0.954 1 0.546 1 0.572 1 0.61 1 0.639 1 1.117 1 48 4.95 1 3 826.32837 -1.49 18.86 2476.97055

KFVGVQLCNSLR ABI3BP target of Nesh-SH3 precursor [Homo sapiens]

25890 NP_056244 NP_079077

2 1 33667044 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio)

78 5.34 0 2 1006.481 -1.98 58.58 2011.95464

KFVQGK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 1 2 62739186 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K6(iTRAQ4plex)

64 4.38 0 2 657.40076 -6.79 17.58 1313.79424

KFYNQVSTPLLR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 10 1 70778918 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

6.16 0 4 461.7619 3.09 24.75 1844.02578

KGEVLPLPEANFPSFPLPHHK

HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 14 1 4504489 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K21(iTRAQ4plex)

3.159 5 71.6 0.781 5 34.9 2.916 5 6.2 2.989 4 58.2 3.318 5 18.1 3.381 5 145.8 1.128 5 10.5 107 8.22 0 3 1109.1243 2.36 71.05 2217.249

Page 23: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

KGEWVALNPLR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 79 2 62739186 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

2.73 6 12.9 0.926 5 15.6 2.421 6 24.2 2.822 5 9.7 2.751 6 22.7 3.134 5 13.5 1.125 6 1.9 93 8.34 0 3 1112.6168 0.59 57.94 2224.22275

KGGSFQLNELQGLK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 1 2 312433998 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.879 6 11.1 0.934 6 13.5 2.725 6 10.5 3.004 6 14.2 3.05 6 15.4 3.135 6 14.4 1.108 6 3.4 90 4.83 0 2 743.46643 -1.87 64.64 1485.92681

KGHIYQGSEADSVFSGFLIFPSA

C1QA complement C1q subcomponent subunit A precursor [Homo sapiens]

712 NP_057075 8 1 7705753 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

2.48 7 33.1 1.065 7 16.4 2.226 7 33.8 2.436 7 15.5 2.509 7 30.2 2.821 7 11.4 1.127 7 9.4 85 5.35 0 2 778.92072 -5.01 42.59 1556.83391

KGHVLFRPTVSQQQSCPTCSTSLLNGHFK

ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 1 2 156119625 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C16(Methylthio); C19(Methylthio); K29(iTRAQ4plex)

2.556 2 8.4 0.987 2 10 2.488 2 14.8 2.522 2 4.7 2.592 2 12 2.627 2 2 1.042 2 2.8 80 3.39 0 2 778.92072 -5.01 42.59 1572.82756

KGNVATEISTER APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 7 1 105990532 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.869 4 9.7 0.911 4 20.4 1.799 4 20.5 2.008 4 10.6 1.754 4 16.2 1.979 4 8.4 1.003 4 4.2 77 3.9 0 2 684.39435 2.99 25.14 1367.78142

KGVCEETSGAYEK AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 2 1 4502067 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); K13(iTRAQ4plex)

2.864 2 21.9 1.038 2 24.8 2.753 2 32.5 2.653 2 7.3 3.101 2 37.5 2.988 2 11.9 1.126 2 4.6 76 6.16 0 3 858.00909 0.85 31.5 1715.01194

KGYTQQLAFR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 6 1 115298678 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

2.674 2 4.3 0.824 2 13 2.401 2 0.6 2.914 2 13.6 2.48 2 3.6 3.01 2 9.4 1.033 2 4.2 63 7.97 0 3 1112.6168 0.59 57.94 2240.22232

KHIKAEHADMK ZBTB40 zinc finger and BTB domain-containing protein 40 [Homo sapiens]

9923 NP_055685 1 1 139394556 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K4(iTRAQ4plex); K11(iTRAQ4plex)

3.04 4 0.7 0.943 4 5.8 2.815 4 2.9 2.977 4 5.3 3.205 4 3.3 3.367 4 4.4 1.139 4 0.9 60 3.69 0 2 696.38654 0.46 41.09 1391.76872

KHNLYFEAAFDVPLK BTD biotinidase precursor [Homo sapiens]

686 NP_000051 3 1 4557373 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.405 7 12.7 0.984 7 14.7 2.218 7 24.8 2.341 7 7.5 2.538 7 23.7 2.688 7 5.3 1.148 7 2.3 37 3.2 0 2 599.81787 4 31.22 1198.6237

KICLDLQAPLYK PF4 platelet factor 4 precursor [Homo sapiens]

5196 NP_002610 3 1 4505733 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C3(Methylthio); K12(iTRAQ4plex)

1.332 2 4.9 0.811 2 20.8 1.091 2 74.1 1.344 2 48 1.198 2 34.3 1.477 2 58.1 1.099 2 130.1 35 0 3 1305.3328 3.08 77.89 3913.98374

KIENCNYAVELGK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 4 167614506 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C5(Methylthio); K13(iTRAQ4plex)

1.066 1 1.067 1 1.053 1 0.987 1 1.151 1 1.078 1 1.093 1 25 0 2 565.25934 -0.24 26.28 1129.5114

KIQCVDGEWTTLPTCVEQVK

CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 2 1 13540563 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); C15(Methylthio); K20(iTRAQ4plex)

1.442 1 1.002 1 1.351 1 1.348 1 1.536 1 1.533 1 1.137 1 33 0 2 608.84967 -3.95 34.61 1216.69206

KITEVALMGHLSCDTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C13(Methylthio); K16(iTRAQ4plex)

1.776 1 1.863 1 2.769 1 1.486 1 2.317 1 1.244 1 0.837 1 3.82 2 4 898.96729 -4.62 55.24 3592.84731

KIYPTVNCQPLGMISLMK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

6 3 4504893;156231037

K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio); K18(iTRAQ4plex)

0.839 7 12.2 1.061 7 13.1 0.831 7 19 0.783 7 12.9 0.889 7 13.5 0.869 7 18.1 1.197 7 19.5 103 8.14 0 3 1269.1782 3.14 55.61 2537.345

KIYPTVNCQPLGMISLMK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

4 3 4504893;156231037

K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio); M13(Oxidation); M17(Oxidation); K18(iTRAQ4plex)

0.814 8 16.4 1.033 8 16 0.788 8 13.7 0.819 8 15 0.888 8 21.2 0.924 8 18.2 1.141 8 2.3 101 5.31 0 2 787.90228 2.03 30.29 1574.79302

KIYPTVNCQPLGMISLMK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

4 3 4504893;156231037

K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio); M17(Oxidation); K18(iTRAQ4plex)

0.487 1 0.911 1 0.403 1 0.442 1 0.528 1 0.58 1 1.312 1 87 8.13 0 3 1269.1782 3.14 55.61 2521.35495

KLAGDESAD PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 7 1 4505981 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

0.698 3 12.5 1.12 3 0.1 0.665 3 9.2 0.641 3 20.8 0.736 3 0.1 0.681 3 5.3 1.106 3 6 70 3.67 0 2 662.36884 -7.16 17.69 1323.73039

KLAVEPK ICAM2 intercellular adhesion molecule 2 precursor [Homo sapiens]

3384 NP_001093256 2 1 153082686 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.739 2 16.7 0.983 2 21.9 0.681 2 32.7 0.693 2 10.3 0.788 2 23.8 0.801 2 1.8 1.156 2 8.5 60 4.59 0 2 663.36536 -5.22 15.49 1325.73357

KLCMAALK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 1 2 32483410 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C3(Methylthio); M4(Oxidation); K8(iTRAQ4plex)

1.322 6 6.6 0.965 6 6.1 1.196 6 8.8 1.242 6 6.7 1.295 6 12.5 1.404 6 13 1.119 6 6.9 76 5.55 0 3 765.9303 -1.07 31.48 1530.84848

KLCMAALK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 2 2 32483410 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

1.102 2 42.4 1.144 2 9.5 1.116 2 35.6 0.975 2 46.2 1.249 2 37.8 1.091 2 48.6 1.119 2 2.1 53 3.55 0 2 661.37598 -4.57 20.54 1321.74468

KLDGICWQVR C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 11 1 166197660 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C6(Methylthio)

1.268 3 9.8 1.004 3 7.8 1.174 3 17.1 1.17 3 9.1 1.366 3 10.9 1.361 3 3.1 1.163 3 5.2 48 3.96 0 2 643.82294 2.49 48.33 1286.6386

KLECNGENDCGDNSDER C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 4 1 169636415 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); C10(Methylthio)

1.293 4 11.3 0.851 4 13.8 0.987 4 3.5 1.251 4 11.3 1.267 4 8.4 1.473 4 2.6 1.243 4 8 81 5.96 0 3 1099.5811 -1.62 52.95 2198.15512

KLGQSLDCNAEVYVVPWEK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

63 3 4504893;156231037

K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio); K19(iTRAQ4plex)

0.924 3 8.4 1.027 3 21.7 0.811 3 6.4 0.906 3 20.6 0.959 3 3 1.018 3 11 1.183 3 3.4 80 5.04 0 2 944.49146 0.04 31.95 1887.97563

KLGSYEHR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 2 1 70778918 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.58 2 5.5 0.951 2 20.8 1.429 2 16 1.503 2 4.7 1.661 2 15.3 1.747 2 5.4 1.162 2 0.8 72 4.87 0 2 944.49146 0.04 31.95 1903.98564

KLINDYVK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 5 1 50659080 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.186 2 1.6 0.984 2 0.1 1.09 2 4.8 1.107 2 4.9 1.264 2 1.3 1.284 2 1.2 1.16 2 6.1 32 0 2 461.23123 0.52 11.54 921.45519

KLISVDTEHSNIYLQNGPDR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 12 1 4557485 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.042 1 1.06 1 1.034 1 0.976 1 1.113 1 1.05 1 1.076 1 91 2.89 0 2 633.86853 0.1 16.87 1266.72978

KLPPGLLANFTLLR LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 2 1 16418467 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.117 1 0.923 1 1.01 1 1.094 1 1.138 1 1.232 1 1.126 1 35 3.31 0 2 575.85736 -0.01 30.16 1150.70745

KLSFYYLIMAK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.522 1 1.035 1 1.442 1 1.393 1 1.656 1 1.6 1 1.148 1 3.19 0 2 656.36267 -16.62 18.96 1311.71807

KLSFYYLIMAK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 1 1 66932947 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M9(Oxidation); K11(iTRAQ4plex)

1.246 1 1.073 1 1.244 1 1.159 1 1.339 1 1.248 1 1.077 1 3.56 2 3 960.48901 -15.28 57.45 2879.45249

KLSSWVLLMK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 4 1 189163538 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.955 1 0.884 1 0.824 1 0.932 1 0.975 1 1.103 1 1.184 1 50 4.21 0 2 642.33624 -4.7 17.55 1283.66521

KLTISEQNIQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.474 199 14.5 1.017 199 20.7 1.399 199 16.9 1.365 199 14.5 1.59 199 21.2 1.553 199 16.7 1.134 199 10.9 112 6.76 0 2 1166.5172 -3.46 42.32 2332.03434

KLWAYLTINQLLAER ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 55 1 70778918 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.884 7 18.1 1.257 7 35.1 2.094 7 24.1 1.51 7 13.2 2.138 7 59.8 1.852 7 9.6 1.198 7 12 109 6.95 0 3 1169.9104 4.13 72.25 3507.71701

KLYDYCDVPQCAAPSFDCGKPQVEPK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 12 1 4505881 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C6(Methylthio); C11(Methylthio); C18(Methylthio); K20(iTRAQ4plex); K26(iTRAQ4plex)

1.414 24 5.6 1.03 24 14.5 1.352 24 11 1.326 24 11.4 1.524 24 13.7 1.495 24 12.4 1.112 24 7 104 6.08 0 2 928.01245 -1.51 58.65 1855.01763

KMEDLTNVSSLLNMERAR CENPQ centromere protein Q [Homo sapiens]

55166 NP_060602 2 1 40068061 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M2(Oxidation)

1.493 56 34.1 0.943 56 30.2 1.435 56 44.9 1.487 56 53.3 1.604 56 46.9 1.497 56 47.7 1.097 56 36.9 100 7.26 0 4 1169.9104 4.13 72.25 3491.70913

KMGLAFESTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M2(Oxidation); K10(iTRAQ4plex)

1.125 89 15.7 0.96 89 15.1 1.026 89 13.2 1.069 89 18.4 1.166 89 17.3 1.207 89 17.7 1.114 89 9.8 100 9.46 0 3 870.72034 -2.03 81.23 2610.14646

KMISEKMVK SNX31 sorting nexin-31 [Homo sapiens] 169166 NP_689841 1 1 222537716 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K6(iTRAQ4plex); K9(iTRAQ4plex)

1.353 127 9.7 0.997 127 12.4 1.266 127 15.3 1.254 127 14.7 1.451 127 13.3 1.444 127 16.2 1.127 127 10.9 99 6.42 0 3 1174.4666 -1.19 47.84 2347.93137

KMTSNFPVDLSDYPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M2(Oxidation); K15(iTRAQ4plex)

1.356 13 10.4 0.941 13 20.3 1.23 13 6.4 1.337 13 14.5 1.358 13 13.5 1.524 13 12.7 1.162 13 11.6 97 7.59 0 3 870.72034 -2.03 81.23 2626.1561

KMYFDAVQAIETHLIR MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 2 1 24497519 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M2(Oxidation)

1.166 112 10.4 0.923 112 14.2 1.075 112 15.9 1.154 112 12.4 1.176 112 13.2 1.288 112 11.2 1.135 112 10.2 97 8.78 0 3 1260.5231 -0.41 34.66 2520.04941

KNEIDLESELK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 1 1 73623026 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.147 183 8.2 1.027 183 10.9 1.103 183 12.2 1.07 183 8.8 1.223 183 11.1 1.192 183 8.8 1.108 183 6.1 95 5.85 0 2 851.8009 -2.4 53.81 1702.59453

KNIFISPVSISMALAMLSLGTCGHTR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 4 1 73858564 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M16(Oxidation); C22(Methylthio)

1.297 102 9.5 0.955 102 9.7 1.186 102 11.9 1.253 102 10.3 1.349 102 10.9 1.417 102 10.7 1.132 102 9 93 5.73 0 3 558.63312 -1.14 59.32 1673.89287

KNIFISPVSISMALAMLSLGTCGHTR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 6 1 73858564 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M12(Oxidation); M16(Oxidation); C22(Methylthio)

1.39 81 14.5 0.967 80 16.1 1.268 81 15.7 1.28 80 19.1 1.494 81 18.8 1.527 80 15.1 1.172 81 14.4 91 8.23 0 3 877.01532 5.24 62.35 2629.02646

KNQGILEFYGDDIALLK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 10 3 14550407 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.328 66 19.1 0.989 66 22.1 1.236 66 26.2 1.331 66 18.2 1.425 66 23.8 1.456 66 20.3 1.109 66 19.9 87 8.01 0 3 1327.7443 2.6 81.05 2654.48125

KPAITYGTR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 1 1 21071039 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.332 103 9.7 0.972 103 10.8 1.233 103 10.9 1.273 103 11.1 1.402 103 11.7 1.443 103 12.9 1.125 103 8.7 82 7.3 1 3 1064.1019 -9.82 31.8 2127.21915

KPCDTSDPQCPPDGR VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 2 1 223633991 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C3(Methylthio); C10(Methylthio)

1.392 57 8.2 0.978 57 13.6 1.293 57 13 1.327 57 6.5 1.451 57 11.9 1.466 57 5.3 1.102 57 6.6 82 5.22 0 2 776.86078 -15.17 22.9 1552.7437

KPDVSHGEMVSGFGPIYNYK

C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 7 1 4502503 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.391 192 12.8 0.897 191 17.7 1.238 192 19.9 1.346 191 20.4 1.436 192 18.7 1.572 191 16.9 1.15 192 16.9 81 8 0 4 1420.6431 0.4 44.4 2840.27982

KPDVSHGEMVSGFGPIYNYK

C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 6 1 4502503 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M9(Oxidation); K20(iTRAQ4plex)

1.987 45 10.6 0.986 45 9.8 1.901 45 13.9 1.914 45 11.5 2.08 45 14.3 2.074 45 10.6 1.108 45 5 79 4.96 0 3 851.8009 -2.4 53.81 1718.59111

KPFLLLAIK B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Homo sapiens]

10678 NP_006568 2 1 9845238 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.347 9 6.6 1.076 9 6.6 1.337 9 5.6 1.262 9 4.9 1.445 9 4.8 1.37 9 5.5 1.091 9 3.7 75 4.34 0 3 729.92798 -4.95 22.46 1458.8624

KPIIGILMQK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 4 1 4503987 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.239 2 9.4 1.043 2 4.5 1.227 2 10.6 1.177 2 15.1 1.302 2 3.7 1.249 2 8.2 1.061 2 6.9 68 8.54 1 3 868.75079 2.14 29.7 2604.23178

KPIWLSQMSCSGR CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 4 1 5174411 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C10(Methylthio)

1.431 147 7.7 0.995 147 12 1.339 147 15.2 1.373 147 5.9 1.52 147 14.1 1.569 147 7.5 1.143 147 4.1 66 3.93 0 2 613.84656 -1.03 28.55 1226.6873

KPLIGTVLAMDPDAAR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 2 1 166362713 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M10(Oxidation)

1.288 12 7.2 0.835 12 8.3 1.067 12 16 1.283 12 10.4 1.217 12 19.2 1.47 12 5.8 1.141 12 7.8 65 4.56 0 3 466.94473 0.77 77.16 1398.81964

KPVAFSDYIHPVCLPDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 18 1 4503635 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C13(Methylthio)

1.474 11 11.7 1.064 11 5.7 1.494 11 15.8 1.412 11 10.5 1.678 11 8.8 1.577 11 6.8 1.121 11 5.6 60 4.22 0 2 641.81061 10.07 15.13 1282.61394

KPVAFSDYIHPVCLPDRETAASLLQAGYK

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 5 1 4503635 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C13(Methylthio); K29(iTRAQ4plex)

1.982 3 42.8 0.916 3 3.8 1.935 3 60 1.977 3 48.2 1.987 3 38.2 2.031 3 27.7 1.145 3 2.5 58 5.27 1 3 894.03265 -3.3 17.46 1787.05625

KPYNVESYTPQTQGK C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 4 1 4557391 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.401 21 4.3 0.936 21 15.4 1.253 21 14.5 1.377 21 7.1 1.457 21 12.6 1.551 21 8.9 1.163 21 5 58 3.25 0 2 483.29648 -1.35 14.12 965.57353

KQELSEAEQATR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 4 1 115298678 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.082 66 4.7 1.033 66 6 1.038 66 7.3 1.005 66 5.1 1.167 66 4.9 1.127 66 5.8 1.134 66 4.1 55 3.5 0 2 542.30121 -1.47 2.28 1083.59502

KQLGAGSIEECAAK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 8 2 4505881 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C11(Methylthio); K14(iTRAQ4plex)

1.233 4 46.2 1.056 4 16.9 0.753 4 31.4 0.621 4 76.5 1.654 4 60.7 1.508 4 53.7 2.521 4 83.9 54 5.12 0 4 1192.2618 3.47 80.89 3574.77553

KSDIDEIVLVGGSTR HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 2 1 16507237 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.417 113 5.1 0.956 113 10 1.307 113 8.5 1.361 113 4.9 1.481 113 7.5 1.518 113 7.7 1.121 113 4.1 53 3.51 0 2 614.31158 -12.78 19.88 1227.63335

KSDVGFLPPFPTLDPEEK AFM afamin precursor [Homo sapiens] 173 NP_001124 6 1 4501987 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.717 12 35.7 0.939 12 12.8 1.582 12 86.4 1.705 12 67.4 2.146 12 81.1 2.174 12 78.7 1.001 12 26.2 50 7.42 0 4 1192.2618 3.47 80.89 3590.74802

KSPQELLCGASLISDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 18 1 4503635 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio)

1.085 2 21.4 0.998 2 7.7 1.062 2 15.4 1.064 2 23.3 1.105 2 19.5 1.108 2 27.5 1.041 2 4 46 4.9 1 3 500.29462 -9.9 19.21 1498.8693

KSSSAAASSSASSSSAILPAGGGGGGGGGGSR

CXXC4 CXXC-type zinc finger protein 4 [Homo sapiens]

80319 NP_079488 1 1 365812517 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.27 8 28.9 1.058 8 10.2 1.222 8 37.9 1.293 8 18.6 1.371 8 33.1 1.305 8 29 1.099 8 5.1 46 3.03 0 2 544.35138 -0.98 16.32 1087.6978

KSTDADLAMSKSAVK BIN3 bridging integrator 3 [Homo sapiens]

55909 NP_061158 1 1 8923904 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K11(iTRAQ4plex); K15(iTRAQ4plex)

1.394 9 5.2 0.979 9 6.6 1.278 9 6.8 1.34 9 3.8 1.445 9 7.8 1.445 9 4.2 1.103 9 4.2 46 3.83 0 3 620.86127 1.02 12.88 1240.71805

KTDELPQLVTLPHPNLHGPEILDVPSTVQK

FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 1 3 16933542 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K30(iTRAQ4plex)

1.361 141 6.9 0.961 141 10.5 1.239 141 11.2 1.298 141 6.9 1.421 141 10.1 1.48 141 6.3 1.13 141 3.9 44 3.37 0 2 691.27783 -1.1 84.65 1381.54839

KTEEVECLTYGWSLTPK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 4 1 110611237 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C7(Methylthio); K17(iTRAQ4plex)

1.352 1 0.953 1 1.256 1 1.317 1 1.385 1 1.453 1 1.103 1 43 2.92 0 2 553.31561 -0.44 15.05 1105.62395

KTLLSNLEEAK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 4 1 355594753 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.7 1 0.882 1 1.599 1 1.814 1 1.6 1 1.815 1 1.001 1 39 0 2 722.41327 -7.28 20.69 1443.81926

KTSLEDFYLDEER SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 14 1 39725934 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.692 1 0.792 1 1.405 1 1.773 1 1.628 1 2.055 1 1.159 1 38 1 3 457.93393 -1.05 16.92 1371.78724

KVEGTAFVIFGIQDGEQR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 29 1 115298678 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

2.183 1 0.358 1 1.896 1 5.294 1 1.069 1 2.984 1 0.564 1 36 4.6 1 4 810.46729 -1.19 79.87 3238.84731

KVETNMAFSPFSIASLLTQVLLGAGENTK

SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 4 1 73858568 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K29(iTRAQ4plex)

0.577 1 1.136 1 0.566 1 0.498 1 0.667 1 0.587 1 1.178 1 33 5.15 1 3 457.93393 -1.05 16.92 1355.78418

KVETNMAFSPFSIASLLTQVLLGAGENTK

SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 6 1 73858568 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M6(Oxidation); K29(iTRAQ4plex)

1.388 7 8.5 0.968 7 4.8 1.296 7 11.7 1.338 7 3.2 1.436 7 12.6 1.483 7 3.9 1.108 7 0.6 31 2.91 0 2 530.28345 0.45 22.95 1059.55864

KVFLDCCNYITELRR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C6(Methylthio); C7(Methylthio)

2.125 2 16.6 0.848 2 11 1.818 2 14.2 2.143 2 25.5 2.111 2 9.1 2.489 2 20.2 1.161 2 5 4.89 0 3 1192.2618 3.47 80.89 3606.75876

KVFSGDGK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 1 1 45580688 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.183 1 0.971 1 1.151 1 1.186 1 1.179 1 1.215 1 1.024 1 4.5 1 3 538.98627 -7.91 18.07 1614.94425

KVLLDGVQNPR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.237 1 0.908 1 1.105 1 1.216 1 1.256 1 1.383 1 1.137 1 3.18 1 2 838.94244 -8.61 24.56 1676.87761

KVMYTQYEDESFTK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M3(Oxidation); K14(iTRAQ4plex)

1.007 1 0.881 1 0.865 1 0.982 1 1.03 1 1.169 1 1.191 1 94 5.12 0 2 904.44873 -2.83 24.43 1807.89018

KVTCTNAELVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 4 2 38016947 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C4(Methylthio); K11(iTRAQ4plex)

1.08 4 12 0.977 4 11.1 0.922 4 4.3 0.944 4 15.9 1.177 4 18 1.193 4 6.7 1.166 4 35.7 90 9.52 0 3 1128.5361 0.94 60.64 3383.59385

KVVATTQMQAADAR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.041 3 6.2 0.771 3 28 0.873 3 19.4 1.133 3 5.9 0.97 3 16.1 1.258 3 11.5 1.111 3 3.1 77 4.66 0 2 617.84918 2.35 15.19 1234.68852

KWVMVPMMSLHHLTIPYFR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 2 1 50659080 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

0.958 2 11.9 0.992 2 23.4 0.96 2 24.8 0.967 2 1.3 0.955 2 22.7 0.962 2 0.7 0.995 2 2 75 9.12 0 3 876.43677 1.76 51.84 2627.29575

KWVMVPMMSLHHLTIPYFR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 3 1 50659080 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M4(Oxidation)

1.106 2 3.7 0.969 2 2.8 1.017 2 0.7 1.049 2 3.4 1.161 2 3.7 1.198 2 6.5 1.142 2 3.1 68 5.19 0 2 845.43164 -0.3 42.25 1689.85881

KYAFELK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 2 2 4502511 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.105 3 3.9 0.946 3 0.7 1.019 3 14.9 1.077 3 14.2 1.224 3 19.3 1.3 3 14.5 1.075 3 2.8 59 5.72 0 3 775.36182 -2.77 17.15 2324.0709

KYFIDFVAR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

24 3 4504893;156231037

K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.016 1 0.819 1 0.893 1 1.09 1 0.956 1 1.167 1 1.07 1 44 3.51 0 2 511.29919 -0.03 38.8 1021.59111

KYNELLK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 2 1 355594753 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.836 1 1.003 1 0.797 1 0.795 1 0.877 1 0.874 1 1.1 1 40 0 2 586.84021 -2.1 36.37 1172.67314

KYNPIPSVQLMGNGFHFLAGEPR

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 5 1 169636415 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.109 1 0.802 1 0.932 1 1.163 1 1.066 1 1.33 1 1.144 1 2.97 0 2 614.86182 2.69 16.24 1228.71636

KYNPIPSVQLMGNGFHFLAGEPR

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 2 1 169636415 K1(iTRAQ4plex); N-Term(iTRAQ4plex); M11(Oxidation)

1.022 1 1.025 1 0.979 1 0.956 1 1.089 1 1.063 1 1.113 1 70 4.8 0 2 639.86053 -0.47 14.5 1278.71379

KYNSQNQSNNQFVLYR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

2 3 4504893;156231037

K1(iTRAQ4plex); N-Term(iTRAQ4plex)

1.011 1 0.758 1 0.804 1 1.061 1 0.974 1 1.285 1 1.211 1 41 5.73 0 3 705.06152 -7.39 25.66 2113.17002

KYPVAHFIDQTLK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 17 1 73858568 K1(iTRAQ4plex); N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.499 1 0.814 1 2.278 1 2.797 1 2.256 1 2.77 1 0.99 1 3.43 0 3 700.37976 0.85 45.59 2099.12473

KYSDASDCHGEDSQAFCEK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C8(Methylthio); C17(Methylthio); K19(iTRAQ4plex)

0.924 3 4.9 0.957 3 9.8 0.843 3 13.2 0.9 3 3.3 0.966 3 14.6 1.042 3 1.3 1.147 3 1.4 70 5.18 0 2 710.88507 8.15 26.33 1420.75139

KYTYNYEAESSSGVPGTADSR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 K1(iTRAQ4plex); N-Term(iTRAQ4plex)

0.993 3 5.9 0.996 3 7.4 0.919 3 0.9 0.922 3 6.4 0.986 3 2.9 1.057 3 9.8 1.073 3 2 47 6.09 0 3 926.84473 -2.72 51.04 2778.51963

Page 24: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

KYVLPNFEVK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

39 6 178557739;67190748

K1(iTRAQ4plex); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.11 1 0.921 1 1.014 1 1.102 1 1.118 1 1.214 1 1.102 1 2.87 0 2 559.81543 -5.37 12.11 1118.62358

KYWNDCEPPDSR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 6 1 4504489 K1(iTRAQ4plex); N-Term(iTRAQ4plex); C6(Methylthio)

1.461 1 1.187 1 1.52 1 1.281 1 1.674 1 1.41 1 1.101 1 38 0 2 541.33105 4.86 18.3 1081.65483

LAAAVSNFGYDLYR SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 18 1 39725934 N-Term(iTRAQ4plex) 1.242 1 0.771 1 1.09 1 1.413 1 1.11 1 1.439 1 1.018 1 3.85 0 4 721.61292 -7.95 39.63 2883.42983

LAACGPPPVAPPAAVAAVAGGAR

IGFBP2 insulin-like growth factor-binding protein 2 precursor [Homo sapiens]

3485 NP_000588 4 1 55925576 N-Term(iTRAQ4plex); C4(Methylthio)

1.01 1 1.063 1 1.017 1 0.957 1 1.067 1 1.003 1 1.049 1 51 3.21 0 2 523.29181 0.44 21.99 1045.57634

LAACLEGNCAEGLGTNYR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 189 1 4503635 N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio)

1.131 1 0.967 1 1.06 1 1.096 1 1.164 1 1.204 1 1.098 1 34 4.3 1 3 566.64905 -6.35 33.9 1697.93259

LAAYLMLMR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 32 1 105990532 N-Term(iTRAQ4plex) 1.167 1 1.025 1 1.076 1 1.05 1 1.288 1 1.257 1 1.197 1 24 3.79 0 4 527.98682 10.38 33.72 2108.92544

LAAYLMLMR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); M6(Oxidation)

1.257 2 10.6 0.778 2 6.8 1.091 2 10 1.403 2 16.9 1.144 2 5.4 1.472 2 12.2 1.049 2 4.6 103 5.21 0 3 981.04504 5.89 54.56 1961.06925

LACGAVLIHPSWVLTAAHCMDESK

PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 6 1 4506115 N-Term(iTRAQ4plex); C3(Methylthio); C19(Methylthio); K24(iTRAQ4plex)

1.106 2 11.6 0.952 2 9.4 1.049 2 5.4 1.101 2 14.8 1.113 2 8.5 1.168 2 18 1.061 2 3.1 87 7.18 0 3 1190.1947 1.8 58.83 2379.38596

LACGAVLIHPSWVLTAAHCMDESKK

PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 2 1 4506115 N-Term(iTRAQ4plex); C3(Methylthio); C19(Methylthio); K24(iTRAQ4plex); K25(iTRAQ4plex)

1.177 4 3.5 0.956 4 19.8 1.097 4 7.9 1.06 4 6 1.249 4 6.4 1.195 4 5.6 1.137 4 4.6 84 5.33 0 2 743.46649 0.91 39.03 1485.91533

LADFALLCLDGK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 6 2 312433998 N-Term(iTRAQ4plex); C8(Methylthio); K12(iTRAQ4plex)

0.693 1 0.927 1 0.617 1 0.666 1 0.718 1 0.775 1 1.163 1 49 4.38 0 3 451.58716 -0.6 30.48 1352.74692

LADGGATNQGR LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 2 1 5031863 N-Term(iTRAQ4plex) 1.004 1 0.893 1 0.883 1 0.988 1 1.018 1 1.14 1 1.154 1 47 3.82 0 2 856.409 1.68 39.09 1711.81072

LAEAADLLNREGRR TRANK1 TPR and ankyrin repeat-containing protein 1 [Homo sapiens]

9881 NP_055646 XP_047357 XP_945720

3 1 257467636 N-Term(iTRAQ4plex) 1.32 2 2.8 1.006 2 3.1 1.248 2 2.2 1.241 2 0.9 1.399 2 6.3 1.391 2 3.2 1.121 2 4.1 3.17 0 2 591.32544 0.02 43.16 1181.6436

LAEGFPLPLLK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 9 1 31652249 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.894 1 1.21 1 2.062 1 1.704 1 2.124 1 1.755 1 1.03 1 3.44 2 3 801.45624 -18.24 74.47 2402.35416

LAELEEALQK KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 4 1 119395754 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.04 1 0.925 1 0.932 1 1.007 1 1.07 1 1.157 1 1.148 1 41 3.5 0 2 687.29193 -0.23 40.23 1373.57659

LAELPADALGPLQR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 8 2 4826772 N-Term(iTRAQ4plex) 1.379 1 0.912 1 1.217 1 1.334 1 1.419 1 1.556 1 1.166 1 35 5.86 0 4 732.10254 -2.39 21.65 2925.38833

LAFESENINSEIHCDR MMRN1 multimerin-1 precursor [Homo sapiens]

22915 NP_031377 4 1 45269141 N-Term(iTRAQ4plex); C14(Methylthio)

2.314 1 1.168 1 2.419 1 2.07 1 2.598 1 2.223 1 1.074 1 2.8 0 2 909.50317 19.49 38.71 1817.99907

LAGAPSEDPQFPK QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

7 2 13325075 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.867 1 0.971 1 0.801 1 0.825 1 0.907 1 0.934 1 1.132 1 2.76 0 2 661.39899 -4.76 27.46 1321.7907

LAGDESAD PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 1 1 4505981 N-Term(iTRAQ4plex) 1.627 1 0.884 1 1.487 1 1.682 1 1.579 1 1.786 1 1.062 1 3.89 2 4 873.17188 -14.92 52.06 3489.66567

LAGLGLQQLDEGLFSR VASN vasorin precursor [Homo sapiens] 114990 NP_612449 6 1 88702793 N-Term(iTRAQ4plex) 1.305 1 0.939 1 1.235 1 1.315 1 1.296 1 1.38 1 1.049 1 5.24 0 3 649.32886 0.29 20.98 1945.97202LAGTELLIEK ZNF174 zinc finger protein 174 isoform b

[Homo sapiens]7727 NP_001027463 2 1 73808088 N-Term(iTRAQ4plex);

K10(iTRAQ4plex)1.961 1 0.954 1 1.763 1 1.847 1 2.069 1 2.168 1 1.174 1 53 3.49 0 2 530.28156 0.64 22.33 1059.55583

LAGYLHTLVQNLVNNGYVR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 16 1 4557892 N-Term(iTRAQ4plex) 1.351 1 0.81 1 1.087 1 1.343 1 1.358 1 1.677 1 1.249 1 51 5.78 0 3 753.03357 1.45 29.01 2257.08615

LAIPQQSDFHNNR CSF1R macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens]

1436 NP_005202 4 1 27262659 N-Term(iTRAQ4plex) 2.232 1 1.139 1 2.278 1 2 1 2.496 1 2.191 1 1.096 1 43 3.99 0 3 833.81781 -3.09 80.76 2499.43888

LALDLEIATYR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 14 11 119395750 N-Term(iTRAQ4plex) 1.416 1 1.037 1 1.361 1 1.312 1 1.524 1 1.47 1 1.12 1 99 5.42 0 2 730.92267 4.72 18.64 1460.83806

LALDNGGLAR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

8 2 31542984;262050538

N-Term(iTRAQ4plex) 1.49 1 0.912 1 1.336 1 1.465 1 1.513 1 1.659 1 1.132 1 57 4.41 0 2 741.86914 -0.92 31.02 1482.731

LALDVEIATYR KRT5;KRT6A;KRT2

keratin, type II cytoskeletal 5 [Homo sapiens];keratin, type II cytoskeletal 6A [Homo sapiens];keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3852;3853;3849

NP_000415;NP_005545 NP_490596;NP_000414

3 10 119395754;5031839;47132620

N-Term(iTRAQ4plex) 1.237 1 0.978 1 1.146 1 1.171 1 1.302 1 1.33 1 1.136 1 56 4.36 0 2 920.97968 -0.58 28.5 1840.95207

LALENYITALQAVPPRPR APP amyloid beta A4 protein isoform f precursor [Homo sapiens]

351 NP_001129602 6 10 209915573 N-Term(iTRAQ4plex) 1.39 1 0.945 1 1.273 1 1.346 1 1.432 1 1.514 1 1.125 1 51 3.54 0 2 716.83899 1.79 38.68 1432.6707

LALETALMYGAK F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 2 1 119395709 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.44 1 0.881 1 1.253 1 1.423 1 1.456 1 1.653 1 1.162 1 35 3 0 2 660.28345 -2.52 40.49 1319.55962

LALLVDTVGPR CPQ plasma glutamate carboxypeptidase precursor [Homo sapiens]

10404 NP_057218 NP_006093

1 1 7706387 N-Term(iTRAQ4plex) 1.531 1 1.045 1 1.477 1 1.414 1 1.653 1 1.582 1 1.119 1 33 3.09 0 2 701.35046 0.55 27.23 1401.69365

LALWGEHTGQLYSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 21 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.857 1 1.1 1 1.653 1 1.502 1 2.247 1 2.042 1 1.36 1 6.09 0 4 810.6167 0.17 60.74 3239.44497

LANLTQGEDQYYLR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 2 1 355594753 N-Term(iTRAQ4plex) 1.481 1 1.015 1 1.425 1 1.404 1 1.559 1 1.535 1 1.094 1 3.11 0 2 649.36035 -3.07 53.63 1297.71343

LAPGELTIIL APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 17 1 105990532 N-Term(iTRAQ4plex) 1.182 1 1.01 1 1.125 1 1.115 1 1.251 1 1.239 1 1.111 1 34 3.07 0 2 582.28729 1.03 21.37 1163.56731

LAPLAEDVR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 7 1 71773110 N-Term(iTRAQ4plex) 1.028 1 0.906 1 0.956 1 1.055 1 1.003 1 1.108 1 1.05 1 54 6.84 0 3 655.31879 -2.8 46.84 1963.94181

LAQDQK PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 1 1 192447438 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.311 1 0.925 1 1.161 1 1.255 1 1.364 1 1.474 1 1.175 1 69 3.82 0 2 775.42761 -11.08 38.29 1549.84795

LAQFVARNGPEFEKMTMEK CHERP calcium homeostasis endoplasmic reticulum protein [Homo sapiens]

10523 NP_006378 2 1 119226260 N-Term(iTRAQ4plex); K14(iTRAQ4plex); K19(iTRAQ4plex)

2.359 1 0.928 1 2.15 1 2.317 1 2.398 1 2.585 1 1.115 1 57 5.84 0 3 1102.2606 -1.07 49.5 3304.76731

LAQKVPTADLEDVLPLAEDITNILSK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 2 2 32483410 N-Term(iTRAQ4plex); K4(iTRAQ4plex); K26(iTRAQ4plex)

1.459 1 1.064 1 1.431 1 1.344 1 1.581 1 1.485 1 1.105 1 3.01 0 2 740.427 -13.12 33.05 1479.84673

LAQQSQALQELISELDRR TRIM21 E3 ubiquitin-protein ligase TRIM21 [Homo sapiens]

6737 NP_003132 1 1 15208660 N-Term(iTRAQ4plex) 0.747 2 11.1 0.99 2 2 0.746 2 10.2 0.753 2 8.2 0.742 2 14.1 0.749 2 12.1 0.995 2 3.8 97 7.92 0 3 1046.0714 -5.38 45.32 2091.14902

LASLFPALFSR MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 2 2 19923761 N-Term(iTRAQ4plex) 0.827 1 0.971 1 0.761 1 0.784 1 0.87 1 0.896 1 1.143 1 45 4.17 0 2 822.36456 2.88 54.35 1643.72185

LASPGFPGEYANDQER MASP2 mannan-binding lectin serine protease 2 isoform 2 precursor [Homo sapiens]

10747 NP_631947 4 2 21264361 N-Term(iTRAQ4plex) 0.794 2 21 0.942 2 8.7 0.725 2 23.3 0.77 2 14.4 0.818 2 27.2 0.869 2 18.2 1.129 2 3.7 3.58 0 2 588.36664 -0.77 32.98 1175.726

LASQACR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 1 1 145275213 N-Term(iTRAQ4plex); C6(Methylthio)

1.721 1 1.07 1 1.63 1 1.523 1 1.934 1 1.807 1 1.186 1 3.47 0 3 655.35651 -7.24 28.24 1964.05497

LASSTTFSNQAESMMVPGNAAGVAK

UNC79 protein unc-79 homolog [Homo sapiens]

57578 NP_065869 XP_350940

1 1 150456444 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.118 1 0.94 1 1.053 1 1.12 1 1.116 1 1.188 1 1.06 1 85 5.86 0 2 1082.067 -2.67 37.96 2163.12676

LASYLDK KRT16;KRT14;KRT19;KRT9;KRT10

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens];keratin, type I cytoskeletal 19 [Homo sapiens];keratin, type I cytoskeletal 9 [Homo sapiens];keratin, type I cytoskeletal 10 [Homo sapiens]

3868;3861;3880;3857;

3858

NP_005548;NP_000517;NP_002267;NP_000217;NP_000412 XP_352920

8 10 24430192;15431310;24234699;55956899;195972866

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.968 1 0.862 1 0.84 1 0.974 1 0.964 1 1.118 1 1.148 1 67 7.39 0 3 757.68024 2.63 34.16 2271.02616

LASYLDKVQALEEANNDLENK

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex); K7(iTRAQ4plex); K21(iTRAQ4plex)

0.975 1 0.908 1 0.901 1 0.993 1 0.958 1 1.055 1 1.063 1 67 4.79 0 2 738.89233 -0.67 39.87 1476.77739

LATALSLSNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.961 1 0.771 1 0.823 1 1.067 1 0.879 1 1.14 1 1.068 1 57 7.61 0 3 801.01532 -0.03 49.81 2401.03141

LAVTTHGLPCLAWASAQAK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 140 1 4503635 N-Term(iTRAQ4plex); C10(Methylthio); K19(iTRAQ4plex)

0.984 1 1.007 1 0.969 1 0.962 1 1.006 1 0.999 1 1.038 1 57 4.15 0 2 663.3183 -1.3 36.78 1325.62932

LAVYQAGAR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 6 1 4557325 N-Term(iTRAQ4plex) 1.066 1 0.956 1 0.992 1 1.038 1 1.094 1 1.144 1 1.102 1 42 3.38 0 2 773.36279 -0.59 23.46 1545.71831

LAYLQPALFSGLAELR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 12 2 4826772 N-Term(iTRAQ4plex) 1.071 1 0.938 1 0.991 1 1.057 1 1.085 1 1.157 1 1.094 1 41 2.92 0 2 662.81335 6.64 27.31 1324.61943

LCDNLSTK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 219 2 32483410 N-Term(iTRAQ4plex); C2(Methylthio); K8(iTRAQ4plex)

0.872 1 0.788 1 0.713 1 0.905 1 0.847 1 1.075 1 1.189 1 39 2.82 0 2 512.75543 -0.06 18.9 1024.50359

LCFFPFVENGHSESSGQTHLEGDTVQIICNTGYR

CFHR1;CFHR2

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 2 precursor [Homo sapiens]

3078;3080 NP_002104;NP_005657

2 2 118442839;5031695

N-Term(iTRAQ4plex); C2(Methylthio); C29(Methylthio)

0.909 1 0.791 1 0.766 1 0.969 1 0.862 1 1.09 1 1.125 1 37 3.96 0 2 639.82617 2.75 32.68 1278.64507

LCFFYNK AFM afamin precursor [Homo sapiens] 173 NP_001124 18 1 4501987 N-Term(iTRAQ4plex); C2(Methylthio); K7(iTRAQ4plex)

0.858 1 1.296 1 0.946 1 0.73 1 1.023 1 0.789 1 1.081 1 5.47 0 4 826.89532 -0.61 64.35 3304.55947

LCMAALK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 126 2 32483410 N-Term(iTRAQ4plex); C2(Methylthio); K7(iTRAQ4plex)

2.016 1 1.389 1 2.091 1 1.506 1 2.725 1 1.962 1 1.303 1 4.68 1 4 881.67285 -9.95 47.66 3523.66958

LCNIEPDER HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 4 1 4504383 N-Term(iTRAQ4plex); C2(Methylthio)

1.461 1 1.024 1 1.413 1 1.38 1 1.544 1 1.508 1 1.093 1 3.57 0 3 819.43719 -2.01 44.28 2456.29703

LCNNPTPQFGGK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 9 1 40317626 N-Term(iTRAQ4plex); C2(Methylthio); K12(iTRAQ4plex)

1.002 6 12.8 0.816 6 21.5 0.904 6 8.1 1.052 6 22.8 0.927 6 9 1.154 6 12.2 1.042 6 10.3 68 8.3 0 3 1241.1743 0.09 47.98 2481.33634

LCNTGDNSVCTTK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 10 1 78191798 N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio); K13(iTRAQ4plex)

1.028 6 4.7 0.894 6 24.8 0.928 6 15.7 1.007 6 22.3 1.029 6 21.1 1.133 6 15.1 1.134 6 4.5 84 9.25 0 3 1310.2013 -2.26 46.41 2619.39731

LCQDLGPGAFR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 23 2 115583663 N-Term(iTRAQ4plex); C2(Methylthio)

1.021 6 14.5 0.928 6 9.2 0.919 6 25.7 1.017 6 15.8 1.025 6 8.8 1.145 6 7.7 1.148 6 6.7 74 5.35 0 3 568.63715 -3 31.87 1703.89798

LCTPLLPK CFP properdin precursor [Homo sapiens] 5199 NP_001138724 12 1 223671861 N-Term(iTRAQ4plex); C2(Methylthio); K8(iTRAQ4plex)

1.056 2 3.8 0.987 2 4.8 0.975 2 2.2 0.988 2 7 1.122 2 0.7 1.137 2 5.5 1.151 2 1.4 65 4.19 0 2 632.36102 0.04 11.73 1263.71477

LCYVALDFEQEMATAASSSSLEK

ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 8 3 4501885 N-Term(iTRAQ4plex); C2(Methylthio); K23(iTRAQ4plex)

0.734 2 15.1 0.999 2 8.3 0.668 2 6.4 0.669 2 14.7 0.798 2 14.8 0.799 2 23.3 1.194 2 8.4 56 3.87 0 2 686.34943 2.48 36.63 1371.69158

LDAHKVLSALQAVQGLLVAQGR

AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 28 1 4557287 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.324 2 6 0.949 2 11.6 1.194 2 10.5 1.258 2 1.1 1.389 2 12.6 1.464 2 1 1.164 2 2 55 3.34 0 2 686.34943 2.48 36.63 1387.68205

LDAPSQIEVK TNC tenascin precursor [Homo sapiens] 3371 NP_002151 2 1 153946395 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.257 3 16.1 0.799 3 24.5 1.049 3 24.4 1.521 3 2.4 1.285 3 11.7 1.479 3 12.5 1.041 3 36.9 52 8.85 0 4 1126.5514 0.34 53.34 3377.64663

LDAQASFLPK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 75 2 156119625 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.009 4 5.2 0.957 4 0.1 0.931 4 5.9 0.973 4 3.7 1.059 4 4.4 1.091 4 4.3 1.126 4 2.6 41 4.8 0 3 565.31757 -0.77 37.99 1693.93814

LDDLFVTGRNVR LSM10 U7 snRNA-associated Sm-like protein LSm10 [Homo sapiens]

84967 NP_116270 1 1 14249632 N-Term(iTRAQ4plex) 1.919 1 0.909 1 1.708 1 1.878 1 1.956 1 2.151 1 1.145 1 40 0 2 686.34943 2.48 36.63 1403.67693

LDETDDPDDYGDR CAPN1 calpain-1 catalytic subunit [Homo sapiens]

823 NP_005177 2 1 12408656 N-Term(iTRAQ4plex) 1.689 1 0.985 1 1.619 1 1.643 1 1.733 1 1.76 1 1.071 1 40 4.02 0 3 568.63715 -3 31.87 1719.89902

LDFSSQADLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 29 1 105990532 N-Term(iTRAQ4plex) 1.073 3 16.4 1.152 3 13.1 1.03 3 27.6 0.991 3 11.8 1.159 3 22 1.115 3 6.4 1.11 3 2 39 2.95 0 2 563.32495 2.84 19.92 1125.62248

LDGENKAVEYNAVGAMK COL22A1 collagen alpha-1(XXII) chain precursor [Homo sapiens]

169044 NP_690848 XP_291257

2 1 40805823 N-Term(iTRAQ4plex); K6(iTRAQ4plex); M16(Oxidation); K17(iTRAQ4plex)

109 7.91 0 3 1166.8254 1.31 59.14 3498.46177

LDGFPPGRPSPDNLNQICLPNR

ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 37 3 221316614 N-Term(iTRAQ4plex); C18(Methylthio)

98 5.89 0 2 1094.9352 -5.25 25.39 2188.87456

LDGICWQVR C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 4 1 166197660 N-Term(iTRAQ4plex); C5(Methylthio)

93 4.7 0 3 694.01233 -2.92 20.15 2080.02243

LDGSVDFK FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

83 6 0 2 1068.016 -0.68 29.83 2135.02471

LDKPDVVNWMCYR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 2 1 4557892 N-Term(iTRAQ4plex); K3(iTRAQ4plex); M10(Oxidation); C11(Methylthio)

71 4.25 0 2 774.36975 -0.12 21.7 1547.73223

LDLQEINNWVQAQMK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 36 1 39725934 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

71 9.17 0 3 1152.1635 5.49 43.75 3454.4758

LDLQEINNWVQAQMK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 5 1 39725934 N-Term(iTRAQ4plex); M14(Oxidation); K15(iTRAQ4plex)

69 8.12 0 3 1070.12 -0.11 77.64 3208.34983

LDLTEKDYEILFK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 2 1 4503987 N-Term(iTRAQ4plex); K6(iTRAQ4plex); K13(iTRAQ4plex)

68 4.58 0 2 1029.9185 -3.88 54.21 2058.82964

LDNIYSSDK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 16 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

55 4.18 0 2 716.78149 -5.26 42.28 1432.56218

LDQIESVITATSANTQLVLETLAQMDDLQDFLSK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 10 1 70778918 N-Term(iTRAQ4plex); M25(Oxidation); K34(iTRAQ4plex)

45 4.49 0 2 790.82733 -0.82 52.71 1580.64946

LDQIESVITATSANTQLVLETLAQMDDLQDFLSK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 13 1 70778918 N-Term(iTRAQ4plex); K34(iTRAQ4plex)

42 3.86 0 3 660.32764 1.46 12.32 1319.64768

LDSLVAQQLQSK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

41 2.93 0 2 716.78149 -5.26 42.28 1448.55217

LDTEDK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 6 1 4557287 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

38 2.92 0 2 578.77588 7.33 29.77 1156.53581

LDTLAQEVALLK CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 18 1 156627579 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

37 4.03 0 2 661.82324 -7.97 39.34 1322.64897

LDVDQALNR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 1 3 7382460 N-Term(iTRAQ4plex) 33 4.02 0 3 445.82486 2.12 38.46 1335.46003

LDVPQNLMFGK ALCAM CD166 antigen isoform 3 precursor [Homo sapiens]

214 NP_001230210 2 4 343168772 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

26 0 2 475.22729 0.9 14.66 949.44731

LDVPVWDVEATLNFLK QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

5 2 13325075 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.231 1 0.836 1 1.038 1 1.242 1 1.222 1 1.463 1 1.178 1 33 0 2 1000.0043 0.58 43.98 1999.00139

LDVTTSIGR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 7 1 105990532 N-Term(iTRAQ4plex) 1.22 18 6 0.944 18 4.8 1.103 18 5.5 1.182 18 5.8 1.248 18 4.5 1.341 18 9.3 1.138 18 4 104 5.66 0 2 1009.5509 0.89 32.34 2018.09343

LEACESLTR HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 2 1 4504383 N-Term(iTRAQ4plex); C4(Methylthio)

1.148 25 11.4 1.014 25 17.6 1.068 25 9.7 1.038 25 12.4 1.212 25 13.7 1.151 25 11.5 1.153 25 5.2 98 5.94 0 2 1020.5022 -0.46 26.49 2039.99541

LEAGDHPVELLAR SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 6 1 4507171 N-Term(iTRAQ4plex) 1.233 28 16.1 0.985 28 19.9 1.205 28 25.2 1.165 28 8.4 1.304 28 19.4 1.349 28 10.7 1.115 28 5.6 91 5.21 0 2 703.40875 -2.76 29.69 1405.81255

LEALPNSLLAPLGR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 16 2 4826772 N-Term(iTRAQ4plex) 1.299 15 14.1 0.923 15 18.8 1.167 15 10.4 1.341 15 18 1.316 15 11.8 1.432 15 10 1.138 15 12.1 89 7.64 0 3 1301.6979 2.69 25.05 2602.38848

LECNGENDCGDNSDER C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 2 1 169636415 N-Term(iTRAQ4plex); C3(Methylthio); C9(Methylthio)

1.239 48 6.2 0.953 48 10.2 1.143 48 7.3 1.189 48 7.8 1.301 48 10.3 1.338 48 8 1.129 48 4.7 88 5.2 0 2 769.40265 0.07 63.29 1537.7946

LEDGVQACHATGCGR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex); C8(Methylthio); C13(Methylthio)

1.143 4 22.6 1.007 4 9.7 1.078 4 26.3 1.113 4 20.3 1.143 4 25 1.212 4 18.9 1.114 4 2.8 81 5.36 1 2 839.50586 -3.99 23.03 1678.00249

LEDMEQALSPSVFK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 46 1 73858568 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.263 2 3.5 1.016 2 0.6 1.206 2 0.9 1.187 2 1.4 1.34 2 5.3 1.32 2 5.8 1.112 2 4.4 73 4.89 0 2 680.38977 -8.25 15.67 1359.77226

LEDMEQALSPSVFK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 8 1 73858568 N-Term(iTRAQ4plex); M4(Oxidation); K14(iTRAQ4plex)

0.978 4 12.5 0.88 4 2.4 0.872 4 14.5 1.033 4 8.7 0.966 4 14.9 1.115 4 10.6 1.061 4 6.3 73 6.68 0 3 1008.9788 0.13 21.29 2016.95066

LEDSVTYHCSR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 18 1 67782358 N-Term(iTRAQ4plex); C9(Methylthio)

1.195 55 9.1 0.956 55 8 1.075 55 14.8 1.153 55 8.9 1.245 55 13.1 1.332 55 10.6 1.137 55 4.8 68 4.81 0 3 478.25238 1.76 22.66 1432.73845

LEDTPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.19 1 0.968 1 1.082 1 1.118 1 1.26 1 1.302 1 1.165 1 63 4.58 0 2 914.46753 -4.38 29.73 1827.92778

LEEIDGFFAR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 2 13325075 N-Term(iTRAQ4plex) 1.005 2 29.2 0.664 2 53.4 0.778 2 54.1 1.172 2 0.5 0.917 2 49.7 1.382 2 3.1 1.18 2 3.7 61 5.61 1 2 839.50848 -0.86 21.43 1678.00969

LEEQAQQIR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 2 1 4557325 N-Term(iTRAQ4plex) 1.062 12 13.3 0.887 12 25.2 1.025 12 18.7 1.064 12 13.7 1.068 12 30.2 1.199 12 12.7 1.12 12 5.8 54 3.66 0 2 621.83795 3.5 17.4 1242.66484

LEGEACGVYTPR IGFBP2 insulin-like growth factor-binding protein 2 precursor [Homo sapiens]

3485 NP_000588 2 1 55925576 N-Term(iTRAQ4plex); C6(Methylthio)

1.018 2 18.3 0.935 2 0.1 0.94 2 11.7 1.006 2 11.6 1.028 2 24.5 1.099 2 24.4 1.093 2 12.6 53 5.35 1 3 530.28601 1.44 17.84 1588.84348

LEGQMGEDGNSIK NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 2 5 115529482 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.187 18 8.1 0.929 18 8 1.05 18 10.9 1.166 18 7.4 1.223 18 9.8 1.325 18 10.5 1.138 18 5.4 51 3.97 0 2 609.82434 -2.7 22.69 1218.64348

LEIDLLK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 4 4 4507875 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.148 12 4.6 0.989 12 3.9 1.043 12 6.4 1.065 12 7 1.201 12 6.9 1.238 12 5 1.147 12 2 47 0 2 438.75412 -1.17 11.39 876.50096

LEIELLK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 3 3 4507875 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.34 1 0.755 1 1.085 1 1.437 1 1.267 1 1.679 1 1.169 1 40 2.77 0 2 621.83795 3.5 17.4 1258.65727

LEIQSQVDSQHVGHSVLTAK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 16 1 105990532 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.283 1 1.209 1 1.328 1 1.099 1 1.507 1 1.247 1 1.135 1 33 3.44 1 3 447.28119 -1.45 15.96 1339.82901

LEIWDGFPDVGPHIGR NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 6 5 66864913 N-Term(iTRAQ4plex) 0.941 2 11.6 0.987 2 44.7 0.811 2 6.8 0.822 2 52.6 1.07 2 22.3 1.084 2 20.8 1.319 2 29.5 33 5.44 0 3 1008.9788 0.13 21.29 2048.9357

LELELRPTGEIEQYSVSATYELQR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 158 1 105990532 N-Term(iTRAQ4plex) 1.065 1 0.943 1 0.982 1 1.041 1 1.087 1 1.152 1 1.107 1 32 0 2 500.27881 0.15 17.65 999.55034

LELHVDGPPPRPQLR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 62 1 21071030 N-Term(iTRAQ4plex) 1.1 4 5.4 0.967 4 8.2 1.019 4 10 1.066 4 2.9 1.161 4 7.1 1.201 4 5.2 1.139 4 1.5 28 0 2 472.73428 0.72 11.85 944.46129

LELLSLSK CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

14 1 256217721 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.217 1 1.139 1 1.227 1 1.077 1 1.376 1 1.208 1 1.122 1 23 0 2 471.71649 -0.66 9.42 942.42571

LELSVDGAK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

176 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.037 1 1.233 1 1.122 1 0.91 1 1.193 1 0.968 1 1.064 1 3.43 0 3 455.26346 -8.76 17.44 1363.77582

LEMNYVVGGVVSHR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 10 1 34734066 N-Term(iTRAQ4plex) 1.25 1 1.056 1 1.205 1 1.142 1 1.364 1 1.291 1 1.131 1 86 4.17 0 2 871.47363 -2.16 29.17 1741.93999

Page 25: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

LEMNYVVGGVVSHR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 2 1 34734066 N-Term(iTRAQ4plex); M3(Oxidation)

1.184 3 4.7 0.984 3 4.2 1.137 3 15.1 1.155 3 3.9 1.217 3 0.6 1.272 3 4.7 1.113 3 6.3 65 4.89 0 2 786.9071 -5.03 24.94 1572.80693

LENEIQTYR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

9 2 195972866 N-Term(iTRAQ4plex) 1.251 1 0.918 1 1.132 1 1.233 1 1.268 1 1.381 1 1.12 1 60 3.91 0 2 609.35211 -0.1 20.56 1217.69695

LEPGKEYLIMGLDGATYDLEGHPQYLLDSNSWIEEMPSER

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

1 6 178557739;67190748

N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.053 1 1.057 1 0.94 1 0.889 1 1.227 1 1.16 1 1.305 1 53 7.25 1 4 728.13812 -2.02 47.89 2909.53066

LEPGQQEEYYR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 4 1 4557892 N-Term(iTRAQ4plex) 1.07 1 0.954 1 0.994 1 1.042 1 1.097 1 1.15 1 1.103 1 49 3.84 0 2 735.96277 1.19 43.68 1470.91826

LEPHEGLLLR SLC3A2 4F2 cell-surface antigen heavy chain isoform f [Homo sapiens]

6520 NP_001013269 1 4 61744483 N-Term(iTRAQ4plex) 1.232 1 0.776 1 0.922 1 1.189 1 1.265 1 1.631 1 1.372 1 44 8.84 0 4 683.58484 3.13 49.19 2731.31753

LEPYADQLR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 16 1 71773110 N-Term(iTRAQ4plex) 1.123 1 0.964 1 1.026 1 1.064 1 1.18 1 1.225 1 1.151 1 36 4.19 0 2 691.87646 -0.21 34.36 1382.74565

LEQGENVFLQATDK C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 22 1 87298828 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.579 1 0.883 1 1.334 1 1.51 1 1.64 1 1.857 1 1.23 1 35 7.26 0 4 719.87042 2.64 54.1 2876.45986

LEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFK

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C10(Methylthio); C24(Methylthio); K35(iTRAQ4plex)

1.008 2 10.8 0.999 2 32.8 0.939 2 33.9 0.94 2 1 1.087 2 21.7 1.088 2 10.6 1.157 2 11.6 62 5.47 0 3 574.68457 -0.74 40.68 1722.03916

LESEETMVLEAHDAQGDVPVTVTVHDFPGK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 17 1 115298678 N-Term(iTRAQ4plex); K30(iTRAQ4plex)

1.027 1 1.101 1 1.095 1 0.994 1 1.063 1 0.966 1 0.971 1 45 1 3 652.69055 -3.09 23.21 1956.0571

LESEETMVLEAHDAQGDVPVTVTVHDFPGK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); M7(Oxidation); K30(iTRAQ4plex)

1.26 2 7.4 0.971 2 13.9 1.167 2 14.1 1.201 2 0.1 1.319 2 14.5 1.358 2 0.5 1.131 2 0.4 85 4.05 0 2 718.41962 -5.56 33.71 1435.83806

LESLLEEK ANGPTL3 angiopoietin-related protein 3 precursor [Homo sapiens]

27329 NP_055310 2 1 7656888 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.065 1 0.897 1 0.971 1 1.083 1 1.05 1 1.171 1 1.082 1 49 4.06 0 2 701.32361 1.97 20.44 1401.63994

LETTVNYTDSQRPICLPSK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 1 1 4503627 N-Term(iTRAQ4plex); C15(Methylthio); K19(iTRAQ4plex)

0.921 1 0.748 1 0.773 1 1.034 1 0.836 1 1.119 1 1.082 1 44 5.83 0 3 547.25861 -2.62 18.98 1639.76126

LEVANMQAELVAKPSVSVEFVTNMGIIIPDFAR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex); M6(Oxidation); K13(iTRAQ4plex)

1.237 1 1.035 1 1.15 1 1.111 1 1.369 1 1.322 1 1.19 1 3.67 1 3 956.80237 -12.61 47.51 2868.39255

LEVANMQAELVAKPSVSVEFVTNMGIIIPDFAR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); M6(Oxidation); K13(iTRAQ4plex); M24(Oxidation)

1.107 1 0.905 1 0.992 1 1.097 1 1.117 1 1.235 1 1.125 1 77 5.79 0 3 509.60648 -0.27 24.15 1526.80487

LEVHYHNPLVIEGR DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex) 1.167 4 5.6 1.033 4 20.1 1.159 4 7.6 1.164 4 11.6 1.194 4 6.2 1.205 4 8.3 1.058 4 2.5 70 4.68 0 2 1016.5338 -1.3 56.44 2032.06828

LEVLNFDFQANAQLSNPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 89 1 105990532 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.098 2 4.4 0.802 2 3.4 0.911 2 4.9 1.136 2 8.3 1.068 2 1.3 1.332 2 4.7 1.173 2 3.6 70 5.25 0 3 994.97186 3.43 17.51 1988.93497

LEYLLLSR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 5 2 4826772 N-Term(iTRAQ4plex) 1.665 1 0.843 1 1.454 1 1.724 1 1.616 1 1.917 1 1.112 1 4.44 0 4 721.64648 -0.02 62.07 2883.56411

LEYPTCAK CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

5 2 118442839;62739186

N-Term(iTRAQ4plex); C6(Methylthio); K8(iTRAQ4plex)

1.062 1 0.714 1 0.827 1 1.159 1 0.993 1 1.392 1 1.201 1 2.89 1 2 681.37823 -9.95 14.05 1361.74919

LFDEINPETK SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 12 1 7705879 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.626 59 13.3 0.937 59 11 1.47 59 19.2 1.599 59 11.7 1.688 59 19.7 1.823 59 11.9 1.137 59 7.1 110 6.26 0 2 912.53845 -1.37 61.93 1824.06963

LFDSDPITVTVPVEVSR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 34 1 355594753 N-Term(iTRAQ4plex) 1.753 7 27.6 0.902 7 15.6 1.553 7 14 1.778 7 34.8 1.733 7 21.1 2.135 7 44.4 1.124 7 8.1 109 6.64 0 2 1036.5813 0.05 70.42 2072.15532

LFFLQVK MSN moesin [Homo sapiens] 4478 NP_002435 4 3 4505257 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.678 47 61.3 0.943 46 14 1.636 47 98.8 1.61 44 81.5 1.739 45 103.5 1.798 44 97.2 1.043 45 28.9 109 10.15 0 5 1510.6803 -1.04 60.82 4530.02634

LFGEVTSPLFPKPYPNNFETTTVITVPTGYR

C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

12 1 66347875 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.834 15 19.9 0.919 15 14.2 1.638 15 22.3 1.868 15 16 1.808 15 22.3 2.024 15 22.5 1.122 15 11.8 107 7.3 0 4 1183.152 -1.67 53.86 2365.30058

LFGPDLK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 10 2 115583663 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.567 14 5.3 0.829 14 26.8 1.441 13 18.7 1.579 13 8.5 1.566 14 11.4 1.883 14 22.3 1.137 13 7.3 103 9.43 0 3 1262.1097 -0.41 34.22 2523.21221

LFHTNFYDTVGTIQLINDHVK

SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 26 1 21361302 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.869 17 9.3 1.046 17 12.7 1.773 17 18.3 1.755 17 12 1.917 17 15.7 1.891 17 8.2 1.102 17 5.3 101 6.94 0 2 938.48126 -1.39 32.69 1875.95378

LFLEALVDSVAQGIPFQQHQFDK

NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 6 1 66346698 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.563 17 4.2 1.002 17 4.9 1.49 17 10 1.49 17 5.6 1.648 17 9.5 1.671 17 6.7 1.101 17 2.7 101 5.94 0 2 914.4397 -1.43 39.39 1827.86272

LFLEETK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.81 37 14.2 1.052 37 16.2 1.721 37 16.4 1.518 37 18.5 1.974 37 12.9 1.879 37 15.9 1.146 37 15.3 101 6.73 0 3 1064.0794 -2.93 56.24 2127.16037

LFLGALPGEDSSTSFCLNGLWAQGQR

SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 2 2 7382460 N-Term(iTRAQ4plex); C16(Methylthio)

1.642 2 7.8 1.07 2 21.8 1.599 2 20.3 1.495 2 1.5 1.809 2 18.1 1.691 2 3.6 1.131 2 2.1 100 6.51 1 2 1085.6039 1.7 21.79 2170.20049

LFQELQPLYLNLHAYVR ACE angiotensin-converting enzyme isoform 1 precursor [Homo sapiens]

1636 NP_000780 2 3 4503273 N-Term(iTRAQ4plex) 1.72 17 19.1 1.052 17 51.4 1.565 17 19.1 1.706 17 32.1 2.086 17 33.4 1.844 17 27.4 1.166 17 22.2 99 8.83 0 3 1043.2085 0.99 78.06 3127.61094

LFQGLGK IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 4 2 4826772 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.595 5 9.3 0.945 5 3.8 1.432 5 14.9 1.667 5 13.9 1.678 5 5.2 1.776 5 4.5 1.046 5 5 98 10.65 0 3 921.79993 -0.59 45.85 2763.38523

LFQGLGKLEYLLLSR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 1 2 4826772 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.677 22 29 0.811 22 74.7 1.424 21 29.1 1.709 21 38.8 1.577 21 21.5 2.08 21 32 1.167 22 22 95 10.97 0 3 968.24713 1.64 81.54 2902.72684

LFQPLTHLK CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

4 1 256217721 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.767 4 21 0.979 4 21.5 1.427 4 8.2 1.614 4 20.6 1.843 4 23.6 1.868 4 22.6 1.16 4 16.1 93 9.11 0 3 1262.1097 -0.41 34.22 2539.20627

LFSLKPTSGPVLTVTLFGR VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 6 1 223633991 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.538 11 18.3 0.863 11 18.4 1.434 11 16.9 1.603 11 19.7 1.434 11 29.7 1.636 11 16.3 1.134 11 16.4 93 7.17 0 3 1202.1141 -3 50.92 2403.22515

LFWEPMK GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 11 1 6006001 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.572 15 23 0.903 15 23.5 1.533 15 22.9 1.716 15 29 1.502 15 25.3 1.697 15 24.1 1.039 15 23.7 92 8.71 0 3 1404.2763 0.63 80.12 2807.54521

LGADMEDVCGR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 6 1 4557325 N-Term(iTRAQ4plex); C9(Methylthio)

1.717 57 12.5 0.95 57 12.5 1.561 57 14.5 1.687 57 12.2 1.76 57 12.1 1.902 57 8.5 1.128 57 6.3 92 6.63 0 3 953.0921 -0.36 39.79 1905.18125

LGADMEDVCGR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 5 1 4557325 N-Term(iTRAQ4plex); M5(Oxidation); C9(Methylthio)

1.673 15 15.5 0.95 15 28.1 1.549 15 14.9 1.478 15 28.7 1.74 15 25.7 1.825 15 21.5 1.188 15 17.4 90 5.63 0 3 1036.5813 0.05 70.42 2056.15849

LGCSLNQNSVPDIHGVEAPAR

DAG1 dystroglycan preproprotein [Homo sapiens]

1605 NP_001171114 2 1 294997306 N-Term(iTRAQ4plex); C3(Methylthio)

1.173 12 25.4 0.986 12 24.4 1.042 12 28.2 1.186 12 29.5 1.207 12 22.5 1.304 12 15.5 1.147 12 21.8 90 6.3 0 3 893.05444 3.08 71.94 2677.14878

LGDDIWIIYEQVMIAALDYGR

EMC2 tetratricopeptide repeat protein 35 [Homo sapiens]

9694 NP_055488 1 1 7661910 N-Term(iTRAQ4plex) 1.747 19 14 0.931 19 11.4 1.561 19 19 1.672 19 20 1.737 19 18.1 1.929 19 13.2 1.177 19 6.8 89 6.41 0 3 1130.0902 5.51 74.26 2259.16294

LGDDLLQCHPAVK PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 11 1 4506115 N-Term(iTRAQ4plex); C8(Methylthio); K13(iTRAQ4plex)

1.709 60 9.6 0.938 60 14.4 1.563 60 10.4 1.672 60 11.3 1.73 60 12.9 1.884 60 14.5 1.141 60 9.8 88 8.58 0 3 730.38202 0.64 77.63 2189.1315

LGEFWLGNDNIHALTAQGTSELR

FCN2 ficolin-2 isoform b precursor [Homo sapiens]

2220 NP_056652 3 2 8051586 N-Term(iTRAQ4plex) 1.769 10 8.5 0.97 10 10.8 1.627 10 8.3 1.694 10 6.8 1.862 10 13 1.846 10 8.6 1.101 10 6.1 85 4.44 0 2 800.39087 0.81 25.85 1599.77178

LGEHNIEVLEGNEQFINAAK PRSS1 trypsin-1 preproprotein [Homo sapiens]

5644 NP_002760 1 2 4506145 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.622 18 6.5 0.913 18 8.8 1.441 18 9.6 1.573 18 11.8 1.71 18 13 1.859 18 9.6 1.149 18 5.3 84 5.54 0 2 863.97992 1.68 78.91 1726.95256

LGEVNTYAGDLQK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 41 1 71773110 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.328 2 10.2 1.188 2 20.7 2.432 2 4 2.047 2 16.7 2.672 2 1.7 2.25 2 22.5 1.099 2 5.7 84 3.95 0 2 886.9118 -5.46 23.25 1772.81633

LGEYDLR PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 1 1 4506115 N-Term(iTRAQ4plex) 1.6 8 9.2 0.926 8 14 1.443 8 21.1 1.448 8 9.6 1.653 8 21.4 1.681 8 10.7 1.136 8 5.2 83 6.63 0 3 531.26428 -3.15 17.07 1591.78177

LGFTDLFSK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 23 1 21361302 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.417 3 0.8 1.035 3 63.3 1.589 3 48.7 1.701 3 31.7 1.957 3 1.6 1.892 3 2.8 1.134 3 14 80 7.95 0 3 1060.1816 0.08 39.49 3178.53916

LGMFNIQHCK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 3 1 189163538 N-Term(iTRAQ4plex); M3(Oxidation); C9(Methylthio); K10(iTRAQ4plex)

1.87 10 9.3 1.101 10 26 1.871 10 12.4 1.75 10 12.1 2.017 10 22 1.973 10 6.7 1.114 10 4.2 80 7.69 1 3 773.40363 2 30.67 2318.19632

LGMFNIQHCK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 4 1 189163538 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

1.682 13 18.8 0.924 13 10.5 1.448 13 13.1 1.603 13 12.3 1.684 13 10.6 1.762 13 11.6 1.109 13 8.3 79 3.4 0 2 624.81848 -0.33 21.69 1248.62969

LGMMVDLSHVSDAVAR DPEP2 dipeptidase 2 precursor [Homo sapiens]

64174 NP_071750 2 1 11641269 N-Term(iTRAQ4plex) 1.665 20 18.5 0.96 20 21.2 1.53 20 28.4 1.65 20 7.8 1.695 20 33.5 1.837 20 11.2 1.113 20 3.3 78 4.72 0 2 760.88208 -3.61 25.81 1520.75688

LGNFPWQAFTSIHGR C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 3 1 289547636 N-Term(iTRAQ4plex) 1.732 17 15 0.907 17 29.7 1.488 17 22.8 1.786 17 15.2 1.643 17 19 2.153 17 15.2 1.151 17 12.3 77 9.18 0 3 940.48932 -0.03 55.04 2819.46

LGNNPVSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

2.023 4 24 0.816 4 3.2 1.641 4 18.9 1.838 4 7 2.142 4 25.2 2.455 4 21.6 1.209 4 10.6 77 6.38 0 3 1293.1534 8.09 36.56 2585.27671

LGNQEPGGQTALK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 4 1 115583663 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.72 22 4.9 0.982 22 12 1.576 22 17.8 1.628 22 10.9 1.782 22 12.1 1.835 22 8.8 1.117 22 4.1 76 4.61 0 2 824.48602 -1.51 26.87 1647.96428

LGNWSAMPSCK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 2 1 153266841 N-Term(iTRAQ4plex); M7(Oxidation); C10(Methylthio); K11(iTRAQ4plex)

1.581 4 4.6 1 4 11.4 1.463 4 15.8 1.464 4 2.5 1.697 4 5.6 1.639 4 2.3 1.117 4 5.8 75 5.68 0 2 886.9118 -5.46 23.25 1756.82549

LGPHAGDVEGHLSFLEK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 67 1 71773110 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.515 2 0.1 0.91 2 0.1 1.355 2 5.4 1.49 2 5.4 1.536 2 5 1.689 2 5.1 1.133 2 10.5 74 4.5 0 2 1125.869 0.24 31.2 2250.73076

LGPISADSTTAPLEK TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 4 1 188528648 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.576 24 14.2 1.002 24 9.5 1.48 24 19.2 1.514 24 8.6 1.676 24 18.3 1.703 24 8.8 1.117 24 3.1 74 4.57 0 2 729.88959 -2.32 30.68 1458.7719

LGPLVEQGR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 6 1 4557325 N-Term(iTRAQ4plex) 1.574 42 9.6 0.958 42 6.9 1.409 42 14.6 1.502 42 10.6 1.668 42 13 1.722 42 9.3 1.154 42 4.6 73 5.77 0 3 554.92511 0.88 66.82 1662.75896

LGQSLDCNAEVYVVPWEK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

153 3 4504893;156231037

N-Term(iTRAQ4plex); C7(Methylthio); K18(iTRAQ4plex)

1.573 6 6.6 0.987 6 11.6 1.442 6 19.6 1.453 6 8.1 1.75 6 11.4 1.731 6 19 1.103 6 6 73 3.76 0 2 684.34674 -4.5 18.4 1367.69304

LGQYASPTAK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

14 6 178557739;67190748

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.643 7 13.1 1.115 7 5.6 2.612 7 16.6 2.422 7 16 2.907 7 11.9 2.59 7 16.8 1.113 7 8.1 70 3.41 0 2 729.88959 -2.32 30.68 1474.76457

LGSLGAACEQTQTEGAK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 22 1 4557389 N-Term(iTRAQ4plex); C8(Methylthio); K17(iTRAQ4plex)

1.585 7 21.9 0.977 7 14.5 1.556 7 21.5 1.617 7 15.2 1.825 7 23.3 1.894 7 21.2 1.199 7 5.8 69 6.29 0 2 791.42871 -0.3 46.48 1581.84612

LGVRPSQGGEAPR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex) 1.786 6 10.6 1.028 6 10.8 1.612 6 13.2 1.652 6 14.8 1.909 6 9.5 1.863 6 10.6 1.1 6 6.3 69 5.4 0 2 826.97974 -5.57 25.31 1652.9522

LGVYELLLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

138 2 31542984;262050538

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.662 9 19.9 0.99 9 12.1 1.602 9 32.6 1.582 9 16.7 1.742 9 26.7 1.759 9 11 1.138 9 5.9 68 4.54 0 2 706.38147 2.05 20.32 1411.7426

LGYVTADGETSGSITCGK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 378 1 62739186 N-Term(iTRAQ4plex); C16(Methylthio); K18(iTRAQ4plex)

1.78 8 12.9 0.975 8 22.6 1.739 8 20.7 1.684 8 9.3 1.878 8 22.5 1.788 8 11.2 1.095 8 3 67 4.81 0 2 731.92719 -2.55 21.85 1462.84709

LHDNQNGWSGDSAPVELILSDETLPAPEFSPEPESGR

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 17 1 21071030 N-Term(iTRAQ4plex) 1.731 4 6.8 0.943 4 9.6 1.604 4 3.1 1.595 4 12.7 1.866 4 2.2 1.856 4 8.7 1.176 4 3.5 65 5.15 0 2 913.48828 2.93 63.09 1825.96831

LHEAFSPVSYQHDLALLR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 15 1 145275213 N-Term(iTRAQ4plex) 1.215 7 18.2 0.965 7 13.9 1.154 7 17.6 1.27 7 11 1.246 7 14.8 1.405 7 11.4 1.082 7 4.7 64 3.51 0 2 667.82623 -4.32 20.15 1334.64263

LHIDEMDSVPTVR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 4 3 4507875 N-Term(iTRAQ4plex); M6(Oxidation)

3.16 13 26.1 0.943 13 47.8 2.637 12 51 2.541 13 26.3 3.428 13 51.4 2.982 13 52.4 1.042 13 23.1 64 7.38 0 4 1309.3242 0.82 76.54 3925.9581

LHIDEMDSVPTVR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 3 4507875 N-Term(iTRAQ4plex) 1.182 1 0.462 1 0.887 1 1.92 1 0.84 1 1.819 1 0.947 1 63 3.78 0 3 1158.2893 2.27 80.62 3472.85337

LHLDYIGPCK SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 5 1 4507171 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

1.951 2 3.8 1.035 2 2.1 1.853 2 4.3 1.79 2 6.4 2.117 2 1.4 2.045 2 3.5 1.142 2 2.9 62 5.46 0 2 982.51611 -4.9 20.63 1964.02495

LHLEGNK LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 3 1 16418467 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.029 1 0.915 1 0.922 1 1.008 1 1.048 1 1.145 1 1.136 1 61 6.14 0 4 1060.1816 0.08 39.49 3194.52456

LHLETDSLALVALGALDTALYAAGSK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

167 6 178557739;67190748

N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.91 11 15.3 0.92 11 18.7 1.674 11 24.1 1.846 11 13.2 1.976 11 16.8 2.201 11 9.6 1.156 11 6.6 60 10.31 0 5 1153.6038 -1.85 43.02 3458.80537

LHLVSPADSGEYVCR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex); C14(Methylthio)

1.823 7 15.2 0.971 6 56.8 1.819 7 20.9 1.656 6 36.5 1.989 7 46 1.834 6 19.8 1.196 7 20.5 60 7.57 0 4 1309.3242 0.82 76.54 3909.97524

LHQPVVLTDHVVPLCLPER F7 coagulation factor VII isoform b precursor [Homo sapiens]

2155 NP_062562 4 2 10518503 N-Term(iTRAQ4plex); C15(Methylthio)

1.97 10 17.8 1.023 10 19.2 1.863 10 36.1 1.889 10 12.4 2.09 10 26 2.052 10 7.2 1.13 10 6.1 59 4.15 0 2 670.36993 -2.3 45.63 1339.73723

LHSLHLEGSCLGR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 8 2 4826772 N-Term(iTRAQ4plex); C10(Methylthio)

1.712 19 20.1 1.008 19 16.6 1.683 19 22 1.658 19 14 1.858 19 22.7 1.847 19 12.3 1.125 19 3.8 57 3.84 0 2 612.87634 0.97 29.09 1224.74224

LHTEAQIQEEGTVVELTGR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 14 1 66932947 N-Term(iTRAQ4plex) 1.456 4 8.4 0.915 4 3 1.36 4 13.7 1.486 4 9.7 1.442 4 8.6 1.621 4 7.1 1.092 4 5.8 56 5.47 1 3 858.474 -1.16 33.44 1715.93698

LHVAGNLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.986 1 0.943 1 0.938 1 0.995 1 0.978 1 1.037 1 1.043 1 55 0 3 1130.8929 -0.43 80.51 3390.66428

LIALTLLGMGLALFR PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 2 1 19923106 N-Term(iTRAQ4plex); M9(Oxidation)

1.868 24 13.3 0.904 24 20.8 1.671 24 21.8 1.86 24 7.3 1.883 24 16.7 2.094 24 6.4 1.137 24 3.5 54 3.33 0 2 599.85852 1.93 36.72 1198.705

LIALTLLGMGLALFR PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 2 1 19923106 N-Term(iTRAQ4plex) 1.592 9 4.9 1.067 9 10.3 1.609 9 17.1 1.464 9 4.7 1.79 9 13.5 1.63 9 6.5 1.112 9 2.8 53 3.12 0 2 576.85052 6.13 21.26 1152.68462

LIANTLCNSR HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 3 2 295054188 N-Term(iTRAQ4plex); C7(Methylthio)

1.749 3 0.3 1.051 3 3.6 1.715 3 3.1 1.632 3 0.4 1.871 3 1.2 1.781 3 2.4 1.091 3 2 53 4.36 0 2 665.83435 -0.14 50.28 1330.66265

LIAPVAEEEATVPNNK LDHB L-lactate dehydrogenase B chain [Homo sapiens]

3945 NP_002291 2 1 4557032 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.62 2 2.4 1.015 2 0.7 1.551 2 0.9 1.528 2 0.2 1.713 2 4.5 1.687 2 3.8 1.104 2 3.6 53 6.22 1 3 561.98785 -0.47 17 1683.94901

LIASMSSDSLR F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 4 1 119395709 N-Term(iTRAQ4plex) 1.67 42 14.3 0.942 42 12.1 1.56 42 15.7 1.679 42 17.9 1.707 42 21.2 1.891 42 20.5 1.145 42 14.1 52 7.64 0 3 842.86682 2.8 51.3 2526.58298

LIDALESHHDTWPPACPPLEPAK

QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

4 2 13325075 N-Term(iTRAQ4plex); C16(Methylthio); K23(iTRAQ4plex)

2.035 3 13.6 0.984 3 1 1.948 3 9.1 1.901 3 16.2 2.172 3 10.9 2.12 3 18.1 1.115 3 1.8 50 5.45 0 2 898.01477 -5.76 18 1795.02226

LIDQYGTHYLQSGSLGGEYR

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 22 1 45580688 N-Term(iTRAQ4plex) 1.538 3 27.5 0.888 3 0.9 1.343 3 12 1.514 3 28 1.56 3 27.1 1.757 3 28.1 1.161 3 0.1 50 4.64 0 3 764.91644 2.46 19.37 1528.82572

LIDVISMYR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex) 1.678 9 8.9 0.953 9 21.4 1.562 9 12.6 1.648 9 3.4 1.771 9 10.3 1.847 9 6.6 1.117 9 6.5 50 3.6 0 2 546.81061 -0.01 9.44 1092.61394

LIDVISMYR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); M7(Oxidation)

1.348 8 26.6 1.034 8 13.3 1.309 8 36.9 1.338 8 34.9 1.466 8 26.2 1.412 8 47.2 1.117 8 2.7 48 3.57 0 2 620.85596 1.52 22.98 1240.69255

LIENGYFHPVK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 1 1 110611237 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.661 6 13.2 0.915 6 15.5 1.481 6 26.6 1.63 6 11.2 1.656 6 35.2 1.866 6 8.5 1.18 6 8.5 47 4.41 1 2 806.46191 -10.02 32.47 1611.9262

LILDIFEYECK GPR116 probable G-protein coupled receptor 116 precursor [Homo sapiens]

221395 NP_056049 2 1 148719673 N-Term(iTRAQ4plex); C10(Methylthio); K11(iTRAQ4plex)

1.89 4 12.7 0.935 4 8.5 1.669 4 20.1 1.8 4 10.5 1.979 4 14.9 2.067 4 9.5 1.175 4 4.2 47 3.75 0 2 697.87891 -0.92 13.98 1394.75151

LILVDYILFK SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 20 1 7705879 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.636 6 10.8 0.884 6 20.8 1.4 6 15.1 1.654 6 11.1 1.658 6 27.5 1.971 6 5.9 1.165 6 5.6 47 4.24 0 3 770.98718 0.36 22.56 1540.95682

LINDYVK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 166 1 50659080 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.82 4 4.6 0.935 4 15.3 1.643 4 12.2 1.851 4 2.2 1.92 4 11.2 2.133 4 3.6 1.165 4 1.1 46 4.01 0 2 614.3623 -0.38 32.14 1227.71733

LIQEAPKPECEK C4BPB C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

725 NP_001017364 2 2 62912462 N-Term(iTRAQ4plex); K7(iTRAQ4plex); C10(Methylthio); K12(iTRAQ4plex)

1.564 2 38.2 1.167 2 20.3 1.699 2 16.9 1.456 2 38.2 1.692 2 36.5 1.449 2 60 0.996 2 18.7 46 3.09 0 2 552.33801 2.21 15.11 1103.66875

LIQWLK THAP4 THAP domain-containing protein 4 isoform 1 [Homo sapiens]

51078 NP_057047 1 1 256818825 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.481 1 0.855 1 0.757 1 0.885 1 0.136 1 0.159 1 0.179 1 46 5.12 0 4 914.97473 0.67 62.48 3656.8771

LISVDTEHSNIYLQNGPDR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 50 1 4557485 N-Term(iTRAQ4plex) 1.603 1 1.035 1 1.54 1 1.489 1 1.721 1 1.663 1 1.117 1 45 2.86 0 2 580.7652 4.85 19.2 1160.52312

LIVAMSSWLQK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 26 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); K11(iTRAQ4plex)

1.866 4 3.5 1.052 4 4.7 1.822 4 8.7 1.744 4 3.6 2 4 3.9 1.84 4 10 1.101 4 4.1 43 0 2 508.32217 -1.94 14.4 1015.63707

LIVAMSSWLQK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.828 1 0.874 1 1.672 1 1.915 1 1.752 1 2.005 1 1.047 1 43 1 2 858.474 -1.16 33.44 1731.94695

LKEDAVSAAFK LUM lumican precursor [Homo sapiens] 4060 NP_002336 7 1 4505047 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex)

1.651 3 16.6 0.92 3 9.6 1.559 3 1.4 1.642 3 4.8 1.712 3 21 1.979 3 11.7 1.206 3 5.5 43 0 2 579.33984 -7.3 18.03 1157.67241

LKEEIGKELEELR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 2 1 71773110 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K7(iTRAQ4plex)

1.661 1 0.882 1 1.442 1 1.636 1 1.683 1 1.91 1 1.168 1 43 3.09 0 2 531.32874 5.35 16.27 1061.65019

LKEGMLSIMSYR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.765 8 8.1 1.001 8 9.1 1.637 8 12.2 1.657 8 6.6 1.818 8 10.4 1.847 8 7.3 1.106 8 2.4 43 3.31 0 2 596.29749 -0.62 11.31 1191.59001

LKEGMLSIMSYR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); K2(iTRAQ4plex); M9(Oxidation)

1.572 1 0.609 1 1.137 1 1.868 1 1.392 1 2.286 1 1.224 1 43 2.78 0 2 523.32672 -14.02 14.6 1045.64617

LKHELTDEELQSLFTNFANVVDK

AFM afamin precursor [Homo sapiens] 173 NP_001124 20 1 4501987 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K23(iTRAQ4plex)

3.55 1 0.929 1 3.226 1 3.47 1 3.624 1 3.899 1 1.124 1 41 3.42 0 2 913.48828 2.93 63.09 1841.96562

LKKPVAFSDYIHPVCLPDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 1 1 4503635 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K3(iTRAQ4plex); C15(Methylthio)

2.994 1 1.077 1 2.899 1 2.692 1 3.318 1 3.081 1 1.144 1 41 6.47 0 4 824.1842 0.72 70.72 3293.71499

LKLEPHEGLLLR SLC3A2 4F2 cell-surface antigen heavy chain isoform f [Homo sapiens]

6520 NP_001013269 1 4 61744483 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.602 20 16.3 1.028 20 9.8 1.445 20 23.5 1.627 20 8 1.655 20 20 1.856 20 7.4 1.13 20 3.1 41 3.31 0 2 593.82855 -2.92 31.7 1186.65666

LKPVDGHCALESK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 3 2 295054188 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C8(Methylthio); K13(iTRAQ4plex)

1.794 13 11.4 1.081 13 11.2 1.782 13 6 1.622 13 5.1 2.018 13 7.3 1.777 13 8.8 1.125 13 3.8 40 3.11 0 2 591.88855 -0.2 33.68 1182.76982

LKYENEVALR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

1 2 195972866 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.802 4 8 0.934 4 10.4 1.632 4 14 1.771 4 1.6 1.853 4 12.3 2.01 4 6 1.135 4 3.7 40 3.09 0 2 505.79645 10.37 28.1 1010.5728

LLAENNEIISNIR MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 2 1 51477714 N-Term(iTRAQ4plex) 1.643 1 0.978 1 1.529 1 1.563 1 1.722 1 1.76 1 1.126 1 39 3.07 0 2 545.81598 -0.07 10.14 1090.62468

LLAGDHPIDLLLR SPARCL1 SPARC-like protein 1 precursor [Homo sapiens]

8404 NP_001121782 4 1 190194423 N-Term(iTRAQ4plex) 1.565 1 1.048 1 1.531 1 1.461 1 1.673 1 1.597 1 1.093 1 39 0 2 570.83685 -2.21 17.42 1140.66643

LLATLCSAEVCQCAEGK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

163 6 178557739;67190748

N-Term(iTRAQ4plex); C6(Methylthio); C11(Methylthio); C13(Methylthio); K17(iTRAQ4plex)

1.188 1 0.985 1 1.094 1 1.111 1 1.263 1 1.282 1 1.154 1 38 0 2 505.78986 -3.6 14.28 1010.57244

LLCNGDNDCGDQSDEANCR

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 8 1 4557391 N-Term(iTRAQ4plex); C3(Methylthio); C9(Methylthio); C18(Methylthio)

2.123 1 0.925 1 1.928 1 2.085 1 2.157 1 2.333 1 1.119 1 37 7.6 0 3 1153.6038 -1.85 43.02 3474.81992

Page 26: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

LLCQCLGFGSGHFR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio)

1.849 1 0.882 1 1.6 1 1.815 1 1.88 1 2.132 1 1.175 1 36 3.48 1 2 711.89319 -0.68 10.03 1422.7791

LLCTDPGFVK KIT mast/stem cell growth factor receptor Kit isoform 2 precursor [Homo sapiens]

3815 NP_001087241 2 2 148005039 N-Term(iTRAQ4plex); C3(Methylthio); K10(iTRAQ4plex)

1.728 7 16.5 0.992 7 20.6 1.812 7 6.6 1.617 7 14.8 1.908 7 6.9 1.774 7 17.4 1.097 7 6.3 35 3.01 0 2 531.34229 -3.39 17.43 1061.68572

LLDLVFLLDGSSR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex) 1.63 2 7.7 0.968 2 0 1.593 2 9.2 1.645 2 9.3 1.615 2 6.1 1.667 2 6.2 1.013 2 3.1 35 2.89 0 2 665.83435 -0.14 50.28 1346.6574

LLDNWDSVTSTFSK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 4 1 4557321 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.123 1 1.112 1 2.199 1 1.978 1 2.284 1 2.054 1 1.038 1 34 0 2 593.82855 -2.92 31.7 1202.65447

LLDSLPSDTR SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 17 1 73858568 N-Term(iTRAQ4plex) 1.762 1 0.926 1 1.623 1 1.753 1 1.771 1 1.912 1 1.091 1 30 0 2 393.75113 -0.58 15.28 786.49498

LLDSSTVTHLFK PSMA6 proteasome subunit alpha type-6 [Homo sapiens]

5687 NP_002782 2 1 23110944 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.901 1 1.24 1 1.769 1 1.427 1 2.49 1 2.009 1 1.408 1 9.06 1 5 723.7951 11.67 35.53 3614.94642

LLELTGPK A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 195 1 21071030 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.495 1 0.766 1 1.276 1 1.666 1 1.363 1 1.78 1 1.068 1 5.52 0 3 656.33197 -2.43 16.28 1966.98136

LLEPHCFPLSLVPTEFCPSPPALK

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 77 1 45580688 N-Term(iTRAQ4plex); C6(Methylthio); C17(Methylthio); K24(iTRAQ4plex)

5.52 0 5 916.86493 2.51 80 4580.29554

LLETECPQYIR S100A8 protein S100-A8 [Homo sapiens] 6279 NP_002955 1 1 21614544 N-Term(iTRAQ4plex); C6(Methylthio)

1.213 1 0.736 1 0.926 1 1.257 1 1.181 1 1.603 1 1.275 1 4.22 0 3 1293.1534 8.09 36.56 2601.28141

LLEVPEGR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 1 1 41393602 N-Term(iTRAQ4plex) 1.662 6 11.2 0.923 6 10.4 1.548 6 19.2 1.641 6 6.9 1.633 6 16 1.809 6 4.7 1.114 6 2.2 3.15 0 2 508.76837 1.28 12.71 1016.52947

LLEYDTVTR APMAP adipocyte plasma membrane-associated protein [Homo sapiens]

57136 NP_065392 1 1 24308201 N-Term(iTRAQ4plex) 1.889 1 0.974 1 1.751 1 1.798 1 1.977 1 2.031 1 1.129 1 2.8 0 2 546.28394 0.34 18.03 1091.56059

LLFDGDAHLLMSIPSPFR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

7 1 154146262 N-Term(iTRAQ4plex) 1.087 1 1.019 1 1.1 1 1.079 1 1.095 1 1.075 1 0.996 1 3.72 2 3 922.15491 -11.98 47.36 2764.45017

LLGEVDHYQLALGK FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 27 2 27754776 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.111 1 0.877 1 1.064 1 1.213 1 1.022 1 1.166 1 0.961 1 3.84 2 4 889.17377 -14.89 52.42 3553.67324

LLGIETPLPK ICAM1 intercellular adhesion molecule 1 precursor [Homo sapiens]

3383 NP_000192 2 1 167466198 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.298 2 4.3 0.875 2 5.4 1.119 2 2.5 1.278 2 2.9 1.315 2 10.6 1.503 2 5.2 1.176 2 8.1 60 6.62 0 3 754.41595 0.91 43.89 2261.23276

LLGLSLAGK LYVE1 lymphatic vessel endothelial hyaluronic acid receptor 1 precursor [Homo sapiens]

10894 NP_006682 NP_057248

8 1 40549451 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.736 1 0.875 1 1.47 1 1.679 1 1.786 1 2.041 1 1.215 1 54 5.67 0 3 714.70245 -1.8 59.41 2142.09281

LLGMETMAWQEIR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 14 3 14550407 N-Term(iTRAQ4plex); M7(Oxidation)

1.088 49 12.3 0.953 49 15 0.984 49 13.8 1.062 49 15.7 1.121 49 11.7 1.179 49 14.2 1.102 49 6.9 128 9.09 0 3 1091.6412 1.17 75.26 2182.27519

LLGMETMAWQEIR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 32 3 14550407 N-Term(iTRAQ4plex) 1.096 15 17.6 1.027 15 17.5 1.015 15 29.9 1.048 15 9.2 1.207 15 19.8 1.104 15 11.3 1.144 15 5.3 113 5.27 0 3 836.44354 -2.06 42.18 1671.88188

LLGMETMAWQEIR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 6 3 14550407 N-Term(iTRAQ4plex); M4(Oxidation); M7(Oxidation)

1.088 16 8.1 0.893 16 12.8 0.96 16 10.2 1.063 16 2.5 1.122 16 7.8 1.257 16 7.8 1.177 16 6 109 8.27 0 3 1122.5989 5.08 38.46 2244.18949

LLIPVTCEFPR OIT3 oncoprotein-induced transcript 3 protein precursor [Homo sapiens]

170392 NP_689848 2 1 22749297 N-Term(iTRAQ4plex); C7(Methylthio)

0.963 4 2.3 0.837 4 49.1 0.596 4 35.4 0.898 4 27.7 0.91 4 23.6 1.206 4 28.5 1.305 4 24.1 108 8.65 0 3 1558.3527 0.4 78.75 3115.69809

LLIQAEQTSDGPNPCDMVK CACNA2D1 voltage-dependent calcium channel subunit alpha-2/delta-1 precursor [Homo sapiens]

781 NP_000713 2 1 54112390 N-Term(iTRAQ4plex); C15(Methylthio); K19(iTRAQ4plex)

1.041 15 18.9 1.033 15 9.2 1.049 15 21.9 1.015 15 14.7 1.15 15 20.3 1.136 15 16.6 1.119 15 6.9 97 5.64 0 2 769.93744 0.46 50.2 1538.8676

LLIYAVLPTGDVIGDSAK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 10 1 66932947 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.251 19 10.9 0.978 19 17.3 1.211 19 12.7 1.199 19 16.3 1.272 19 10.6 1.392 19 11.8 1.09 19 8.6 90 6.51 0 3 1059.5685 1.9 61.11 2118.12139

LLLALR DNHD1 dynein heavy chain domain-containing protein 1 isoform 1 [Homo sapiens]

144132 NP_653267 1 1 222144249 N-Term(iTRAQ4plex) 1.326 3 12.8 1.092 3 0.1 1.266 3 14 1.16 3 17.5 1.508 3 4 1.381 3 9 1.191 3 8.4 85 6.52 0 3 1059.5685 1.9 61.11 2134.1171

LLLFSPSVVHLGVPLSVGVQLQDVPR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

219 6 178557739;67190748

N-Term(iTRAQ4plex) 1.012 9 9.9 0.938 9 11 0.978 9 11.9 0.982 9 6.6 1.061 9 7.4 1.103 9 14.8 1.12 9 6.6 81 5.69 0 2 852.44751 0.21 54.69 1703.88774

LLLLDLSHNSLLALEPGILDTANVEALR

VASN vasorin precursor [Homo sapiens] 114990 NP_612449 1 1 88702793 N-Term(iTRAQ4plex) 1.222 3 0.3 0.778 3 4 1.115 3 14.1 1.223 3 13.8 1.22 3 19.7 1.356 3 16.1 0.995 3 11.4 79 5.53 0 3 798.47522 -0.43 80.35 2393.41056

LLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLK

CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 4 1 4503011 N-Term(iTRAQ4plex); K38(iTRAQ4plex)

0.933 7 18.5 1.116 7 14.9 0.865 7 13.9 0.986 7 8.9 0.899 7 12.7 0.946 7 25.1 1.131 7 2.7 77 4.92 0 2 751.93878 2.27 38.37 1502.87029

LLLQMDSSATAYGSTVSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 24 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); K18(iTRAQ4plex)

1.079 8 11.9 1.051 8 14.2 0.974 8 23.3 1.043 8 9.4 1.178 8 15 1.167 8 8.7 1.136 8 2.6 77 4.4 0 2 717.84534 -0.93 27.04 1434.68059

LLLQQVSLPELPGEYSMK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.062 7 3.4 0.99 7 3.2 0.968 7 10.8 1.017 7 6.1 1.168 7 10.2 1.207 7 4 1.201 7 7.2 76 5.83 1 3 966.98688 -6.66 26.4 1932.96146

LLLQQVSLPELPGEYSMK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex); M17(Oxidation); K18(iTRAQ4plex)

1.075 5 13.6 0.978 5 11.5 1.043 5 18.2 1.02 5 26.7 1.141 5 11.7 1.177 5 9.5 1.154 5 7.1 74 4.89 0 2 830.8941 -0.83 31.19 1660.78203

LLNIQTYCAGPAYLK CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

11 1 256217721 N-Term(iTRAQ4plex); C8(Methylthio); K15(iTRAQ4plex)

0.979 5 22.5 0.906 5 28 0.942 5 36.9 1.063 5 0.4 0.903 5 18.2 1.101 5 9 1.098 5 6 69 4.01 0 2 672.42603 -3.96 22.38 1343.84477

LLNLGLITESQAHTLEDEVAEVLQK

SCG3 secretogranin-3 isoform 1 precursor [Homo sapiens]

29106 NP_037375 1 1 19557645 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.046 16 7.9 0.993 16 12.5 0.986 16 12.7 0.99 16 17.9 1.142 16 12.8 1.093 16 8.5 1.135 16 10 68 6.58 0 3 798.47522 -0.43 80.35 2377.4238

LLPAFHTPSGIPWALLNMK MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 10 1 24497519 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.05 7 7 1.019 7 13.7 1.032 7 15.6 0.967 7 7.6 1.186 7 7.5 1.124 7 5.6 1.15 7 2.4 66 4.12 0 2 657.35443 -13.35 16.76 1313.71709

LLPAQLPAEK ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 8 3 221316614 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.883 2 25.6 0.628 2 16.2 0.664 2 27.3 1.057 2 10.8 0.775 2 36.3 1.235 2 19.3 1.168 2 8.4 54 3.59 0 2 633.36548 -8.47 18.27 1265.72368

LLPHANEVSQK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 2 1 71773110 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.016 1 0.903 1 1.017 1 1.127 1 0.916 1 1.015 1 0.9 1 43 4.66 0 3 1533.1119 3.26 67.02 4597.32126

LLQCVDHSTHPDCALK BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 2 1 168229159 N-Term(iTRAQ4plex); C4(Methylthio); C13(Methylthio); K16(iTRAQ4plex)

0.953 1 0.882 1 0.82 1 0.929 1 0.974 1 1.104 1 1.188 1 41 2.92 0 2 500.2894 1.14 11.66 999.57152

LLQDEFPGIPSPLDAAVECHR

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 1371 1 11321561 N-Term(iTRAQ4plex); C19(Methylthio)

1.117 1 0.973 1 1.026 1 1.055 1 1.178 1 1.211 1 1.149 1 32 2.85 0 2 594.90497 -1.15 13.16 1188.80266

LLQEGQALEYVCPSGFYPYPVQTR

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 70 1 67782358 N-Term(iTRAQ4plex); C12(Methylthio)

0.852 2 17.8 0.953 2 1.9 0.783 2 15 0.822 2 17 0.88 2 18.5 0.924 2 20.5 1.124 2 3.4 32 2.94 0 2 513.79486 1.13 11.06 1026.58245

LLQLPLGFLYVHHTYVPAPPCTDFTR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 24 1 156616294 N-Term(iTRAQ4plex); C21(Methylthio)

1.041 3 0.8 0.912 3 0.8 0.943 3 3.9 1.013 3 3.1 1.066 3 1.2 1.159 3 2 1.135 3 1.8 32 0 2 450.77313 0.69 10.29 900.53899

LLSGGNTLHLVSTTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 55 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.076 2 8.5 1.049 2 14.7 1.045 2 16.7 0.996 2 2 1.163 2 15.5 1.108 2 0.8 1.113 2 1.2 2.87 0 2 503.80057 1.44 14.2 1006.59386

LLSLGAGEFK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.232 1 0.817 1 1.048 1 1.283 1 1.191 1 1.458 1 1.137 1 34 0 2 462.2764 2.61 25.15 923.54552

LLTSFLPAQLLR SLC3A2 4F2 cell-surface antigen heavy chain isoform f [Homo sapiens]

6520 NP_001013269 2 4 61744483 N-Term(iTRAQ4plex) 38 0 2 535.31714 -1.36 34.36 1069.627

LMCAESNR CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 1 1 42544239 N-Term(iTRAQ4plex); C3(Methylthio)

1.133 4 2.2 0.959 4 10.4 1.107 4 8.7 1.139 4 8.2 1.19 4 12 1.252 4 11.5 1.129 4 3.3 34 0 2 480.82101 1.6 17.92 960.63286

LMCAESNR CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 1 1 42544239 N-Term(iTRAQ4plex); M2(Oxidation); C3(Methylthio)

1.47 2 9.4 0.898 2 4.7 1.354 2 2.8 1.508 2 7.5 1.435 2 11.2 1.599 2 16 1.06 2 8.4 4.07 2 3 804.43018 5.55 41.66 2411.27597

LMFFNKTEDDIIWRSQLEK CYB5R4 cytochrome b5 reductase 4 [Homo sapiens]

51167 NP_057314 1 1 84875541 N-Term(iTRAQ4plex); M2(Oxidation); K6(iTRAQ4plex); K19(iTRAQ4plex)

1.658 1 0.802 1 1.365 1 1.701 1 1.623 1 2.022 1 1.188 1 65 5.45 0 3 735.04138 -3.61 56.68 2203.10959

LMISDSHISAVAPGTFSDLIK GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 2 1 4758460 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

0.996 1 0.924 1 0.89 1 0.963 1 1.027 1 1.112 1 1.154 1 60 3.74 0 2 740.86133 -2.4 30.64 1480.71538

LMISDSHISAVAPGTFSDLIK GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 2 1 4758460 N-Term(iTRAQ4plex); M2(Oxidation); K21(iTRAQ4plex)

0.952 1 0.963 1 0.874 1 0.908 1 0.994 1 1.032 1 1.137 1 32 2.97 0 2 487.29373 0.29 31.36 973.58019

LMNIFLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 37 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.349 1 0.832 1 1.23 1 1.478 1 1.242 1 1.492 1 1.01 1 3.84 0 4 713.86609 -14.05 46.5 2852.44253

LMNIFLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 10 1 115298678 N-Term(iTRAQ4plex); M2(Oxidation); K7(iTRAQ4plex)

0.671 2 1.9 0.949 2 11.4 0.601 2 15.8 0.633 2 4.3 0.707 2 0.4 0.745 2 11 1.177 2 15.4 90 5.49 0 2 815.92377 -7.04 21.58 1630.84026

LMQCLPNPEDVK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 4 1 4502503 N-Term(iTRAQ4plex); M2(Oxidation); C4(Methylthio); K12(iTRAQ4plex)

0.974 2 54.2 0.947 2 9.6 0.922 2 57.9 0.973 2 46.4 0.975 2 62 1.03 2 50.2 1.058 2 3.3 86 5.19 0 2 1045.4104 -1.86 27.45 2089.81352

LMTQDCLQQSR F7 coagulation factor VII isoform b precursor [Homo sapiens]

2155 NP_062562 2 2 10518503 N-Term(iTRAQ4plex); C6(Methylthio)

0.473 1 0.909 1 0.443 1 0.487 1 0.46 1 0.506 1 1.039 1 78 6.85 0 3 1217.4733 0.83 21.64 3650.40525

LMVELHNLYR PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 2 1 70780384 N-Term(iTRAQ4plex) 0.714 2 13.3 1.01 2 13 0.668 2 21 0.661 2 7.8 0.769 2 19 0.761 2 5.9 1.151 2 1.9 71 4.92 0 2 770.37653 2.62 19.84 1539.74578

LNCEDIDECR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C3(Methylthio); C9(Methylthio)

0.613 2 12.1 0.879 2 8.3 0.521 2 7.2 0.592 2 15.5 0.631 2 9 0.718 2 17.3 1.211 2 1.8 71 7.49 0 3 838.3222 -3.31 30.96 2512.95206

LNDLEDALQQAK KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 25 2 119395750 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.765 1 0.999 1 0.694 1 0.695 1 0.836 1 0.837 1 1.204 1 68 7.97 1 3 866.44476 0.11 47.02 2597.31974

LNDLEEALQQAK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 12 2 47132620 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.992 1 0.827 1 0.835 1 1.009 1 0.977 1 1.181 1 1.17 1 35 4.45 0 2 966.90344 -10.26 30.49 1932.79961

LNDLNSVLVMPTFHVPFTDLQVPSCK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 115 1 105990532 N-Term(iTRAQ4plex); M10(Oxidation); C25(Methylthio); K26(iTRAQ4plex)

0.652 1 1.028 1 0.608 1 0.592 1 0.715 1 0.696 1 1.176 1 35 5.96 0 3 1069.1018 -0.14 44.77 3205.29087

LNDLNSVLVMPTFHVPFTDLQVPSCK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 44 1 105990532 N-Term(iTRAQ4plex); C25(Methylthio); K26(iTRAQ4plex)

0.593 1 1.116 1 0.497 1 0.445 1 0.757 1 0.679 1 1.525 1 33 0 2 588.31036 -0.23 10.67 1175.61345

LNELSFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.649 1 0.94 1 0.591 1 0.629 1 0.668 1 0.711 1 1.13 1 30 5.24 1 3 1075.4841 0.82 38.7 3224.43784

LNFSQVHIMDEHWRGEALR CNTRL centriolin [Homo sapiens] 11064 NP_008949 XP_352973

1 1 87298937 N-Term(iTRAQ4plex); M9(Oxidation)

1.448 1 0.908 1 1.282 1 1.411 1 1.481 1 1.631 1 1.155 1 3.49 0 2 921.93988 0.58 48.17 1842.87248

LNGEIQALELPQK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.987 1 0.958 1 0.931 1 0.972 1 1.001 1 1.045 1 1.075 1 2.83 0 2 481.27524 -0.33 16.79 961.5432

LNGESNLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex) 1.146 1 1.053 1 1.093 1 1.038 1 1.261 1 1.197 1 1.154 1 71 4.15 0 2 907.40204 -0.42 22.52 1813.7968

LNHQLEGLTFQMK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 10 1 71773110 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.156 1 1.117 1 1.152 1 1.031 1 1.295 1 1.159 1 1.124 1 60 4.25 0 2 839.93427 -6 38.51 1678.86125

LNHQLEGLTFQMK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 6 1 71773110 N-Term(iTRAQ4plex); M12(Oxidation); K13(iTRAQ4plex)

1.248 1 1.149 1 1.224 1 1.066 1 1.457 1 1.268 1 1.19 1 56 4.1 0 2 643.82635 -0.26 20.92 1286.64543

LNILNAK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 1 1 73858566 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.084 1 0.851 1 0.92 1 1.08 1 1.086 1 1.276 1 1.181 1 54 6.61 0 3 717.41595 -4.22 31.84 2150.23331

LNILNNNYK APOL1 apolipoprotein L1 isoform c [Homo sapiens]

8542 NP_001130013 2 3 211938442 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.175 2 2 0.928 2 8.4 1.051 2 6.2 1.132 2 2.3 1.214 2 1.6 1.308 2 10 1.155 2 7.7 53 0 2 598.80463 -0.7 27.93 1196.60198

LNINLK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 2 3 14550407 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.274 2 13.2 0.826 2 22.2 1.17 2 13.3 1.417 2 8.7 1.158 2 33.8 1.403 2 11 0.99 2 19.9 52 4.73 0 3 481.61484 4.36 28.93 1442.82126

LNLAFIANLFNR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 8 1 167614506 N-Term(iTRAQ4plex) 1.08 1 1.102 1 1.029 1 0.934 1 1.241 1 1.126 1 1.206 1 51 6.23 0 3 668.34747 -0.89 57.38 2003.02787LNLVATPLFLKPGIPYPIK C5 complement C5 preproprotein

[Homo sapiens]727 NP_001726 82 2 38016947 N-Term(iTRAQ4plex);

K11(iTRAQ4plex); K19(iTRAQ4plex)

0.912 2 56.9 1.039 2 12.9 0.896 2 65.8 0.862 2 49.9 0.964 2 64.5 0.928 2 48.7 1.076 2 1 44 0 2 514.82404 2.44 25.05 1028.64079

LNMGITDLQGLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

160 6 178557739;67190748

N-Term(iTRAQ4plex) 7.43 3 62.1 1.058 3 50.4 9.059 3 5.1 5.442 3 49.5 10.247 3 8.6 6.302 3 33.2 1.158 3 3.5 115 8.17 0 3 1161.5337 -2.41 37.67 2322.07358

LNMGITDLQGLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

31 6 178557739;67190748

N-Term(iTRAQ4plex); M3(Oxidation)

1.087 1 0.996 1 1.119 1 1.124 1 1.05 1 1.055 1 0.938 1 3.97 1 3 586.30603 -10.05 23.48 1756.90354

LNNGEITQHR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 4 1 4502503 N-Term(iTRAQ4plex) 0.964 6 12.2 0.963 6 16 0.87 6 16.9 0.952 6 19.8 1.035 6 19.8 1.176 6 20.7 1.22 6 4.2 107 6.87 0 3 1170.0888 2.79 54.64 2339.16886

LNTDIAGLASAIDMSTNYNSDSLHFSNVFR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 73 1 105990532 N-Term(iTRAQ4plex); M14(Oxidation)

0.896 7 12.3 0.97 7 11 0.883 7 13.4 0.871 7 5.9 0.952 7 23.6 0.993 7 16.1 1.139 7 8 102 5.79 0 2 795.96802 -1.12 29.25 1590.92851

LNWEAPPGAFDSFLLR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 4 2 188528648 N-Term(iTRAQ4plex) 1.084 3 8.5 0.931 3 0.2 0.88 3 13.7 0.946 3 13.9 1.134 3 10 1.229 3 8.7 1.27 3 12.2 97 6.73 0 2 1092.1094 2.35 40.01 2183.21147

LPDATPTELAK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 1 2 32483410 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.693 3 13.2 0.966 3 11.7 0.607 3 19 0.841 3 4.4 0.764 3 5.3 0.814 3 1.1 0.968 3 3.3 96 6.66 0 3 1148.1002 -3.81 36.09 3442.27512

LPECEADDGCPKPPEIAHGYVEHSVR

HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 16 1 4826762 N-Term(iTRAQ4plex); C4(Methylthio); C10(Methylthio); K12(iTRAQ4plex)

0.952 6 6.2 0.942 6 11.9 0.854 6 10.7 0.919 6 22.1 0.99 6 8.4 1.005 6 9.4 1.201 6 3.8 92 6.43 0 3 880.95966 -2.3 27.13 1760.91556

LPECEAVCGKPK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 15 3 4826762 N-Term(iTRAQ4plex); C4(Methylthio); C8(Methylthio); K10(iTRAQ4plex); K12(iTRAQ4plex)

0.784 5 2.2 1.101 5 8.5 0.752 5 17.3 0.724 5 8.7 0.856 5 11.2 0.813 5 15.2 1.129 5 9.5 89 4.64 0 2 749.40094 5.62 19.69 1497.77349

LPEGSVSLIILLTDGDPTVGETNPR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

111 2 31542984;262050538

N-Term(iTRAQ4plex) 1.138 5 18.1 1.171 5 15.7 1.041 5 32.6 1.101 5 0.5 1.17 5 30.7 1.223 5 2.2 1.124 5 1.9 78 4.76 0 2 805.409 2.35 22.07 1609.8134

LPGDIQVVPIGVGPNANVQELER

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex) 0.738 4 2.6 1.018 4 12.5 0.751 4 10.5 0.75 4 12.1 0.763 4 11.6 0.757 4 6.2 1.091 4 1.2 75 3.36 0 2 739.34216 5.16 20.95 1477.64812

LPGFDSCGK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 7 2 295054188 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

0.768 4 11.2 0.904 4 10.7 0.646 4 12.5 0.714 4 12.3 0.82 4 10.4 0.904 4 10.2 1.266 4 2.1 75 8.56 0 3 1082.556 1.01 20.82 2164.09348

LPLEYSYGEYR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 15 1 4557391 N-Term(iTRAQ4plex) 1.024 3 13.9 0.998 3 8.8 0.959 3 21.6 0.961 3 9.6 1.087 3 18.1 1.089 3 6.2 1.16 3 3.4 74 5.97 0 2 997.01385 1.13 53.69 1993.02043

LPLPVTIK RAB40C ras-related protein Rab-40C isoform b [Homo sapiens]

57799 NP_001166137 1 2 289547669 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.798 2 6 0.998 2 16 0.765 2 14.8 0.767 2 1.1 0.832 2 13.2 0.833 2 2.8 1.087 2 1.7 73 4.82 0 2 870.42419 -3.36 32.7 1739.84111

LPLVPALDGCLR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 18 3 7382460 N-Term(iTRAQ4plex); C10(Methylthio)

0.935 3 13.5 1.007 3 8.1 0.924 3 10.9 0.867 3 10.1 1.007 3 13.2 0.945 3 0.9 1.108 3 2.4 71 4.87 0 2 769.92017 -0.34 42.56 1538.83306

LPNNVLQEK AFM afamin precursor [Homo sapiens] 173 NP_001124 6 1 4501987 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.907 2 2.4 1.115 2 1.6 0.912 2 1.6 0.818 2 0.1 1.006 2 4.6 0.902 2 3 1.103 2 2.9 66 4.92 0 2 758.88599 1.43 30.47 1516.7647

LPPNVVEESAR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 12 1 66932947 N-Term(iTRAQ4plex) 0.885 6 8.5 0.981 6 3.9 0.834 6 1.2 0.841 6 7.4 0.912 6 9.1 0.937 6 6.6 1.135 6 4.9 65 4.58 0 2 695.90387 -1.29 41.87 1390.80046

LPPTTTCQQQK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 47 1 67782358 N-Term(iTRAQ4plex); C7(Methylthio); K11(iTRAQ4plex)

0.814 3 1.3 0.92 3 13 0.701 3 3.8 0.743 3 9.2 0.743 3 2.3 0.909 3 2.8 1.07 3 11.3 64 5.75 1 3 1434.2782 3.38 57.33 2867.54569

LPQQANDYLNSFNWER APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 30 1 105990532 N-Term(iTRAQ4plex) 0.908 3 7.6 0.966 3 13 0.898 3 7 0.887 3 5.9 0.929 3 8.9 0.962 3 22.1 1.074 3 1.3 62 3.4 0 2 912.49884 -4.92 30.77 1823.99712

LPQVSPADSGEYVCR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex); C14(Methylthio)

0.832 1 1.012 1 0.785 1 0.775 1 0.889 1 0.878 1 1.133 1 62 4.72 0 2 959.41974 -4.98 30.77 1917.8322

LPSGLPVSLLTLYLDNNK LUM lumican precursor [Homo sapiens] 4060 NP_002336 36 1 4505047 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.493 1 0.429 1 1.051 1 2.449 1 1.083 1 2.523 1 1.03 1 59 6.29 0 3 1148.1002 -3.81 36.09 3458.27781

LPTDSELAPR SEPP1 selenoprotein P isoform 1 precursor [Homo sapiens]

6414 NP_005401 5 2 62530391 N-Term(iTRAQ4plex) 0.956 5 31.2 0.887 5 12.9 0.896 5 33.5 0.904 5 8.1 1.003 5 37.3 0.987 5 16.1 1.052 5 9.8 59 5.01 0 2 853.86621 -7.73 39.37 1706.73845

LPTGYYFGASAGTGDLSDNHDIISMK

LMAN2 vesicular integral-membrane protein VIP36 precursor [Homo sapiens]

10960 NP_006807 2 1 5803023 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

0.878 3 4.6 0.853 3 0.3 0.792 3 13.1 0.787 3 1.5 0.762 3 4.5 0.894 3 4.2 1.115 3 22.4 57 6.14 1 3 895.67468 -2.46 16.69 2685.00949

LPVANPQACENWLR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

31 1 66347875 N-Term(iTRAQ4plex); C9(Methylthio)

1.064 1 0.578 1 0.671 1 1.16 1 1.009 1 1.745 1 1.504 1 55 6.13 0 3 1105.1332 -1.72 52.99 3313.38498

LPVVHHYGHGSGGISVHWGTALEAAR

DDO D-aspartate oxidase isoform b [Homo sapiens]

8528 NP_004023 1 2 40217827 N-Term(iTRAQ4plex) 0.825 3 0.3 0.969 3 2.7 0.768 3 5 0.792 3 2.3 0.864 3 1.3 0.908 3 4 1.115 3 6.3 52 4.43 0 2 1030.9003 -0.74 50.92 2060.79326

LPYFFHAGETDWQGTSIDR CECR1 adenosine deaminase CECR1 isoform a precursor [Homo sapiens]

51816 NP_059120 3 2 29029550 N-Term(iTRAQ4plex) 0.84 10 9.6 1 10 17.5 0.798 10 11.6 0.843 10 19.1 0.933 10 12.8 0.967 10 10.1 1.128 10 6.3 52 3.72 0 2 708.85748 -2.03 26.56 1416.70586

LPYQCPK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 3 1 119392081 N-Term(iTRAQ4plex); C5(Methylthio); K7(iTRAQ4plex)

0.795 2 9.5 0.863 2 17.8 0.732 2 12.8 0.849 2 4.9 0.75 2 22.7 0.87 2 4.8 1.025 2 9.7 50 3.3 0 2 578.76416 0.26 25.31 1156.52104

LPYTIITTPPLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.529 1 0.966 1 1.42 1 1.47 1 1.587 1 1.642 1 1.118 1 50 2.84 0 2 696.8905 -4.49 23.38 1392.77373

LPYTIITTPPLKDFSLWEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex); K19(iTRAQ4plex)

0.74 2 0.2 0.76 2 15.3 0.615 2 8.4 0.81 2 6.8 0.689 2 4.5 0.907 2 10.7 1.12 2 3.9 50 3.73 0 2 676.36987 -1.02 24.68 1351.73247

LQADDNGDPGR FGL2 fibroleukin precursor [Homo sapiens]

10875 NP_006673 1 1 5730075 N-Term(iTRAQ4plex) 0.919 3 0.4 1.122 3 6.7 0.929 3 4.1 0.813 3 2.6 1.021 3 3.9 0.893 3 2.8 1.1 3 0.2 48 3.05 0 2 630.85535 -1.52 41.28 1260.70305

LQAEAFQAR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 4 1 4557325 N-Term(iTRAQ4plex) 0.858 8 11.4 0.932 8 4.8 0.787 8 9.4 0.826 8 8.2 0.908 8 11.6 0.943 8 11.5 1.132 8 4.8 48 4.04 0 2 567.36298 2.06 55.9 1133.71367

LQAILGVPWK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 17 1 4557287 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.934 2 1 0.884 2 7.7 0.822 2 5.3 0.93 2 2.4 0.939 2 0.3 1.062 2 7.3 1.142 2 4.9 45 3.69 0 2 603.83313 -0.8 30.63 1206.66118

LQAILGVPWKDK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 2 1 4557287 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K12(iTRAQ4plex)

0.629 2 4.7 0.994 2 13.7 0.587 2 13.3 0.591 2 0.4 0.668 2 10 0.672 2 3.7 1.138 2 3.3 45 3.38 0 2 587.80255 0.4 29.28 1174.59783

LQDAEIAR S100A6 protein S100-A6 [Homo sapiens] 6277 NP_055439 1 1 7657532 N-Term(iTRAQ4plex) 0.832 2 0.6 0.903 2 4.7 0.748 2 3.1 0.828 2 1.6 0.837 2 2.6 0.927 2 2.1 1.119 2 0.5 44 3.06 0 2 508.81284 -3.65 33.28 1016.61839LQDEDLGFL CFB complement factor B preproprotein

[Homo sapiens]629 NP_001701 11 1 67782358 N-Term(iTRAQ4plex) 1.113 1 0.934 1 1.07 1 1.146 1 1.082 1 1.159 1 1.011 1 42 1 3 805.70685 -9.17 18.48 2415.10599

LQDFSDQLSDYYEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 27 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.963 2 8.8 0.878 2 16.2 0.886 2 6.6 1.009 2 23 0.925 2 3.8 1.053 2 12.3 1.044 2 10.4 38 6.59 1 3 955.73291 3.19 28.99 2865.18418

LQDGLLHITTCSFVAPWNSLSLAQR

TIMP1 metalloproteinase inhibitor 1 precursor [Homo sapiens]

7076 NP_003245 9 1 4507509 N-Term(iTRAQ4plex); C11(Methylthio)

0.676 1 1.066 1 0.637 1 0.598 1 0.759 1 0.712 1 1.19 1 33 0 2 557.31793 6.21 16.32 1113.62859

LQDLYSIVR COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 2 2 110611233 N-Term(iTRAQ4plex) 0.948 1 0.736 1 0.725 1 0.985 1 0.92 1 1.251 1 1.269 1 27 4.37 0 3 736.63593 -4.51 33.81 2207.89322

LQEGPTSCSGR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C8(Methylthio)

0.594 1 1.044 1 0.951 1 0.911 1 0.263 1 0.252 1 0.276 1 5.98 1 5 796.34082 1.21 50.2 3977.675

LQELHLSSNGLESLSPEFLRPVPQLR

LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 8 1 16418467 N-Term(iTRAQ4plex) 0.901 1 0.954 1 0.823 1 0.863 1 0.937 1 0.983 1 1.138 1 3.46 0 3 374.21896 6.26 10.49 1120.64234

LQETSNWLLSQQQADGSFQDLSPVIHR

C4B complement C4-B preproprotein [Homo sapiens]

721 NP_001002029 NP_000583 XP_001722858

128 2 178557739 N-Term(iTRAQ4plex) 0.852 1 0.967 1 0.776 1 0.803 1 0.9 1 0.931 1 1.16 1 2.89 0 2 458.73563 -0.59 16.87 916.46398

LQETSNWLLSQQQADGSFQDPCPVLDR

C4A complement C4-A isoform 1 preproprotein [Homo sapiens]

720 NP_009224 XP_003403837

14 4 67190748 N-Term(iTRAQ4plex); C22(Methylthio)

1.066 2 2.5 0.89 2 16.8 0.938 2 15.1 1.053 2 1.7 1.079 2 6.3 1.212 2 10.4 1.151 2 8.7 64 5.09 0 2 781.90747 -4.24 23.2 1562.81218

LQGSFDVSVK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 6 1 31652249 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.018 1 0.815 1 0.895 1 1.098 1 0.954 1 1.17 1 1.066 1 40 6.88 0 3 644.67651 1.02 48.18 1932.01499

Page 27: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

LQGSVTVTCR CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 3 1 13540563 N-Term(iTRAQ4plex); C9(Methylthio)

1.146 4 4.6 1.097 4 5.4 1.137 4 6.6 1.035 4 1.4 1.275 4 7.2 1.155 4 3.9 1.121 4 0.6 62 3.72 0 2 580.38251 -6.53 35.23 1159.7708

LQGTLPVEAR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 N-Term(iTRAQ4plex) 0.992 1 1.107 1 0.999 1 0.903 1 1.09 1 0.985 1 1.092 1 53 3.65 0 2 625.39587 4.18 31.51 1249.78447

LQGTSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 2 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.262 1 0.991 1 1.173 1 1.183 1 1.339 1 1.351 1 1.142 1 3.31 0 2 637.40027 4.83 32.36 1273.79326

LQGVEETNIELLVCNYEPPGNVK

PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 2 1 70780384 N-Term(iTRAQ4plex); C14(Methylthio); K23(iTRAQ4plex)

1.358 2 4.5 1.025 2 12.4 1.334 2 14.2 1.301 2 1.8 1.418 2 7.5 1.384 2 4.9 1.063 2 6.7 3.66 1 3 753.07257 7.64 43.76 2257.20316

LQHLENELTHDIITK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 8 1 189163538 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.09 1 0.911 1 0.999 1 1.096 1 1.084 1 1.19 1 1.086 1 103 8.46 0 3 772.36475 0.59 46.75 2315.07969

LQIQEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 2 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.019 2 9.1 1.184 2 8.2 1.046 2 19.9 0.884 2 11.5 1.178 2 8.2 0.995 2 0 1.126 2 11.6 54 4.99 0 3 1016.8022 1.62 64.08 3048.392

LQNNENNISCVER CFHR1;CFHR2

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 2 precursor [Homo sapiens]

3078;3080 NP_002104;NP_005657

8 2 118442839;5031695

N-Term(iTRAQ4plex); C10(Methylthio)

1.07 1 0.924 1 0.967 1 1.046 1 1.093 1 1.182 1 1.13 1 83 7.15 0 3 683.70343 3.47 49.8 2049.09574

LQQVLHAGSGPCLPHLLSR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 17 2 115583663 N-Term(iTRAQ4plex); C12(Methylthio)

1.173 1 0.828 1 1.018 1 1.23 1 1.125 1 1.359 1 1.105 1 32 3.98 0 3 572.31189 -1.98 39.2 1714.92112

LQSLFDSPDFSK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 30 1 39725934 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.523 1 1.062 1 1.468 1 1.383 1 1.671 1 1.574 1 1.138 1 4.35 0 3 782.72192 -14.67 35.89 2346.15122

LQSTTVMNPYMK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); M7(Oxidation); M11(Oxidation); K12(iTRAQ4plex)

0.98 1 0.744 1 0.79 1 1.062 1 0.919 1 1.235 1 1.163 1 123 5.36 0 2 1403.1296 1.95 70.85 2805.252

LQVFQALR H6PD GDH/6PGL endoplasmic bifunctional protein precursor [Homo sapiens]

9563 NP_004276 1 1 52145310 N-Term(iTRAQ4plex) 1.317 35 48.2 0.791 33 63 1.057 34 45.6 1.39 33 68.3 1.351 34 60.3 1.636 33 80.8 1.122 34 33.6 116 11.61 1 3 987.78668 -0.73 63.61 2961.34549

LQVIFK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 11 1 41393602 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.993 8 7.8 0.913 8 12.7 0.915 8 11 1.028 8 15.4 0.962 8 11.1 1.116 8 9.2 1.145 8 18 95 7.03 0 3 1250.5983 -0.72 53.4 2500.19474

LQVVPVAANQR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 1 1 188528648 N-Term(iTRAQ4plex) 1.165 11 7.3 1.044 11 10.3 1.111 11 11.1 1.085 11 9.7 1.269 11 15.7 1.231 11 9.5 1.147 11 7.3 91 5.92 0 2 883.43311 -0.37 15.27 1765.85893

LRPVAAEVYGTER LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex) 1.63 5 15.8 0.941 5 5.7 1.454 5 14 1.62 5 9.4 1.652 5 16.9 1.825 5 11.5 1.137 5 2.9 91 6.23 0 4 998.5401 0.58 23.82 1996.05446

LSALPQGAFQGLGELQVLALHSNGLTALPDGLLR

GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 1 1 4758460 N-Term(iTRAQ4plex) 1.171 2 17.5 0.988 2 8.2 1.125 2 22.3 1.138 2 13.9 1.205 2 21.1 1.22 2 12.7 1.072 2 1.2 91 5.99 0 2 942.44604 -1.18 24.16 1883.8864

LSCSYSHWSAPAPQCK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 4 1 4502503 N-Term(iTRAQ4plex); C3(Methylthio); C15(Methylthio); K16(iTRAQ4plex)

1.148 32 15.4 0.972 32 15.3 1.133 32 18.5 1.09 32 17.9 1.216 32 24.2 1.278 32 15.6 1.117 32 9.2 91 6.23 0 4 1026.5627 -1.65 64.05 2052.11821

LSDLLK SNX6 sorting nexin-6 isoform a [Homo sapiens]

58533 NP_067072 1 4 88703043 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.068 9 8.3 0.818 9 17.5 0.901 9 12.5 1.172 9 15.4 1.02 9 12.1 1.178 9 16.1 1.03 9 21.7 88 4.95 0 3 690.34515 2.14 73.07 2069.01834

LSEAEFEVLK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.125 7 11.6 1.054 7 7.8 1.091 7 29.5 1.08 7 13.1 1.132 7 12.4 1.168 7 19.4 1.139 7 9.4 85 4.97 0 2 830.91296 -14.14 17.65 1660.82768

LSEDYGVLK PRDX2 peroxiredoxin-2 isoform a [Homo sapiens]

7001 NP_005800 1 1 32189392 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.154 15 4.2 0.935 15 16.2 1.029 15 6.8 1.094 15 9.2 1.167 15 5.4 1.273 15 10.1 1.152 15 5.6 85 5.46 0 3 893.94092 -0.94 31.62 1786.87456

LSEEPLQVLEHPR ERAP1 endoplasmic reticulum aminopeptidase 1 isoform b precursor [Homo sapiens]

51752 NP_001035548 2 2 94818891 N-Term(iTRAQ4plex) 1.213 4 11.1 1.036 4 7.3 1.138 4 8.8 1.127 4 7.2 1.325 4 6.4 1.257 4 8.2 1.205 4 11.4 81 5.21 0 2 1034.9679 -6.27 37.36 2068.92851

LSEGASYLDHTFPAEK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 8 1 105990535 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.386 8 19.7 0.974 8 19.5 1.288 8 19.1 1.335 8 26.8 1.388 8 14.4 1.582 8 20 1.135 8 7.3 80 4.69 0 2 893.94092 -0.94 31.62 1802.87236

LSFQEFLK FSTL1 follistatin-related protein 1 precursor [Homo sapiens]

11167 NP_009016 2 1 5901956 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.091 4 5.8 0.815 4 30.3 1.015 4 10.2 1.491 4 9.1 1.005 4 40.3 1.126 4 11.6 0.834 4 36.5 80 6.26 0 3 1167.2231 1.74 60.93 3499.67026

LSFYYLIMAK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 11 1 66932947 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.95 9 20.2 0.971 9 19 0.811 9 40 0.916 9 12.8 1.071 9 14.2 1.061 9 13.2 1.128 9 4.9 78 7.18 0 3 998.5401 0.58 23.82 1980.09409

LSFYYLIMAK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 1 1 66932947 N-Term(iTRAQ4plex); M8(Oxidation); K10(iTRAQ4plex)

1.084 6 7.8 1.004 6 8.6 1.007 6 5.1 1.02 6 8.5 1.158 6 4.5 1.136 6 5.5 1.137 6 5.6 77 4.96 0 3 474.58823 -0.31 24.44 1421.74541

LSGEAYGFVAR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex) 1.042 3 4 1.071 3 3.7 1.099 3 0.9 0.941 3 4.6 1.161 3 4.8 1.049 3 8.1 1.15 3 4.5 77 3.63 0 2 638.87378 4.03 18.43 1276.72746

LSGEVILQIANEPVLPFNALDIALEVQNNLK

NAALADL2 inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 [Homo sapiens]

254827 NP_996898 1 1 126157508 N-Term(iTRAQ4plex); K31(iTRAQ4plex)

1.158 10 11.6 0.986 10 13.6 1.09 10 14.1 1.116 10 28.5 1.238 10 22.9 1.308 10 24.1 1.129 10 3.4 74 5.03 0 2 846.95105 1.34 50.42 1692.89482

LSGNVLSYTFQVK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 16 1 45580688 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.069 4 12.8 1.483 4 26.5 1.499 4 24.7 0.999 4 1.9 1.191 4 25.5 1.069 4 11.4 1.057 4 19.9 74 6 0 3 1167.2231 1.74 60.93 3515.66196

LSIAVK DSG3 desmoglein-3 preproprotein [Homo sapiens]

1830 NP_001935 1 1 119964718 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.06 6 4.3 0.889 6 10.6 0.972 6 11.4 1.044 6 9.3 1.1 6 8.5 1.247 6 24.4 1.11 6 16 72 8.13 0 3 1237.634 2.15 26.91 2474.26023

LSINTHPSQKPLSITVR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 8 1 115298678 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.033 9 2.8 1.073 9 11.6 1.028 9 11.4 0.967 9 14.8 1.157 9 12.3 1.088 9 13.1 1.106 9 4.9 60 3.63 0 2 678.86328 -2.33 39.55 1356.71465

LSITGTYDLK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 21 1 189163538 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.977 7 4.2 0.973 7 15.1 0.94 7 18.9 0.991 7 6.4 1.022 7 11.6 1.085 7 6.4 1.095 7 5.1 60 7.52 0 3 1198.5872 -4.17 42.83 2396.17215

LSITSVTSSVVSTSSNSSDNAPSRPGSDGSILEPLLERRASSGAR

DOCK5 dedicator of cytokinesis protein 5 [Homo sapiens]

80005 NP_079216 XP_209883

1 1 117553586 N-Term(iTRAQ4plex) 2.131 2 20.7 0.773 2 12.8 1.838 2 33.2 2.379 2 19.8 1.939 2 20.3 2.509 2 7.4 1.055 2 12.3 57 6.54 0 4 1012.5052 3.97 38.68 3035.50039

LSLEIEQLELQR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 12 1 4502503 N-Term(iTRAQ4plex) 1.233 10 44.4 0.961 8 32.6 1.189 9 51.7 1.139 9 37.6 0.836 9 81.5 1.228 9 38.9 1.091 10 10.8 53 6.64 1 3 1200.2443 1.14 59.33 3598.71823

LSLESLTSYFSIESSTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 75 1 105990532 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.016 6 8.7 1.077 6 9.2 0.991 6 11.2 0.924 6 8.7 1.117 6 16.3 1.064 6 9.8 1.128 6 2.6 53 3.35 0 2 604.29681 0.46 18.95 1207.58635

LSLIGK POLR3C DNA-directed RNA polymerase III subunit RPC3 [Homo sapiens]

10623 NP_006459 1 1 21359969 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.038 40 5.3 0.948 40 6 0.952 40 6 0.994 40 6.8 1.082 40 6.6 1.14 40 4.5 1.135 40 5.6 49 4.11 0 2 581.85681 -0.14 41.66 1162.70635

LSLLEELSLAENQLLK OGN mimecan preproprotein [Homo sapiens]

4969 NP_054776 3 1 7661704 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.055 2 9.9 1.128 2 2.6 1.108 2 0.4 0.982 2 3 1.129 2 22.9 1.001 2 20.2 1.019 2 23.3 43 3.96 1 2 726.33124 -0.1 19.89 1451.6552

LSLPDFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 17 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.038 11 10.8 1.13 11 11 1.07 11 15.9 0.972 11 4.4 1.145 11 19.7 1.091 11 11.5 1.086 11 5.2 43 0 2 518.34375 -0.26 23.36 1035.67851

LSMDGSPTR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 4 1 78191798 N-Term(iTRAQ4plex) 0.815 1 1.08 1 0.808 1 0.748 1 0.887 1 0.821 1 1.098 1 38 0 2 604.29681 0.46 18.95 1223.57988

LSMDGSPTR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 1 1 78191798 N-Term(iTRAQ4plex); M3(Oxidation)

1.837 5 3.7 1.047 5 6.1 1.73 5 6.1 1.641 5 10.8 1.974 5 4.9 1.845 5 9.9 1.124 5 2 36 3.6 0 3 678.86328 -2.33 39.55 1372.71842

LSMDIDVSYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 46 2 38016947 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.24 1 1.098 1 1.24 1 1.129 1 1.361 1 1.239 1 1.098 1 35 0 2 528.81598 7.25 34.96 1056.62468

LSMDIDVSYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 13 2 38016947 N-Term(iTRAQ4plex); M3(Oxidation); K10(iTRAQ4plex)

0.478 1 1.272 1 0.502 1 0.395 1 0.584 1 0.459 1 1.163 1 35 0 2 533.78455 -3.86 14.32 1066.56182

LSMGSRESVEGSGRSGGSPFLPFSWFTDSGK

SAMD14 sterile alpha motif domain-containing protein 14 isoform 2 [Homo sapiens]

201191 NP_001244288 1 2 383209653 N-Term(iTRAQ4plex); M3(Oxidation); K31(iTRAQ4plex)

1.039 4 5 1.029 4 25.6 0.994 4 14.7 0.945 4 7.3 1.117 4 12.1 1.085 4 13 1.154 4 2.6 32 0 2 487.71976 -2.63 14.42 974.43224

LSNDMMGSYAEMK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); K13(iTRAQ4plex)

0.867 6 7 0.892 6 23.7 0.757 6 9 0.884 6 10.6 0.861 6 14.6 1.019 6 7.6 1.128 6 5 27 0 2 583.27515 -3.52 25.09 1165.54949

LSNDMMGSYAEMK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 29 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); M12(Oxidation); K13(iTRAQ4plex)

44 3.48 0 2 564.25763 -0.53 8.85 1127.50798

LSNDMMGSYAEMK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); M6(Oxidation); M12(Oxidation); K13(iTRAQ4plex)

1.846 1 1.473 1 2.381 1 1.616 1 2.185 1 1.483 1 0.918 1 4.45 1 4 852.94836 19.07 53.24 3408.77163

LSNENHGIAQR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 19 1 70778918 N-Term(iTRAQ4plex) 4.974 2 50.5 0.865 2 10.9 4.356 2 61.3 5.035 2 48.2 4.925 2 52.4 5.693 2 39.9 1.131 2 7.2 49 3.56 0 2 619.84491 -3.69 34.87 1238.68254

LSNNALSGLPQGVFGK CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

17 1 256217721 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.265 2 32.5 0.999 2 18.5 1.212 2 35.2 1.213 2 15.9 1.318 2 49.8 1.319 2 29.2 1.088 2 12.9 118 6.36 0 2 1097.0455 3.49 46.87 2193.08379

LSNVLQQVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.004 3 3.2 1.11 3 1.1 1.021 3 12.7 0.993 3 9.9 1.062 3 6.7 1.075 3 8.9 1.076 3 1 118 9.07 0 3 1149.5657 -0.01 49.52 2298.12375

LSPEELLLR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 4 167614506 N-Term(iTRAQ4plex) 1.079 5 3.1 0.751 5 6.3 0.977 5 10.8 1.097 5 22.3 0.996 5 15.9 1.17 5 22.4 1.031 5 5.1 76 10.26 1 3 890.10889 -3.17 42.14 2668.31906LSPIYNLVPVK C9 complement component C9

precursor [Homo sapiens]735 NP_001728 39 1 4502511 N-Term(iTRAQ4plex);

K11(iTRAQ4plex)0.969 4 12.3 0.732 4 41.8 0.804 4 19.9 1.068 4 15.8 0.953 4 19.1 1.189 4 23.3 1.113 4 11.2 73 7.36 0 3 693.39777 -2.95 27.64 2078.19083

LSPLGEEMR APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 1 1 4557321 N-Term(iTRAQ4plex) 1.186 3 34.5 1.276 3 62.8 1.021 2 3.4 1.154 3 54.4 1.213 3 13.5 1.054 3 29.3 1.061 3 20.4 67 5.72 0 3 951.54486 -11.45 29.97 1902.08292

LSQETEALGR NUCB1 nucleobindin-1 precursor [Homo sapiens]

4924 NP_006175 1 1 20070228 N-Term(iTRAQ4plex) 0.977 4 8.4 0.88 4 9.6 0.825 4 11.1 0.947 4 3 0.999 4 13.2 1.092 4 8.4 1.144 4 10.5 48 4.24 0 2 853.50183 -1.12 26.86 1705.99602

LSQLQTYMIQFDQYIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 16 1 105990532 N-Term(iTRAQ4plex); M8(Oxidation); K16(iTRAQ4plex)

0.812 1 0.773 1 0.67 1 0.866 1 0.77 1 0.996 1 1.149 1 28 0 2 557.25702 8.6 29.5 1113.50676

LSQLSVTDVTTSSLR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 2 188528648 N-Term(iTRAQ4plex) 1.121 1 0.952 1 1.031 1 1.082 1 1.157 1 1.215 1 1.123 1 23 0 2 557.25702 8.6 29.5 1129.49101

LSSGLVTAALYGR BTD biotinidase precursor [Homo sapiens]

686 NP_000051 12 1 4557373 N-Term(iTRAQ4plex) 1.031 3 1.8 0.972 3 9.3 0.933 3 16.3 1.046 3 5 1.074 3 12 1.214 3 8.1 1.161 3 1.2 9.31 0 4 743.15216 1.51 39.08 2969.58681

LSSPAVITDK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 24 1 4505881 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.16 1 1.01 1 1.082 1 1.071 1 1.25 1 1.238 1 1.156 1 2.82 0 2 480.21692 7.29 15.5 959.42656

LSSQISAGEEKWNSVSPASAGKR

MTDH protein LYRIC [Homo sapiens] 92140 NP_848927 2 1 223555917 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K22(iTRAQ4plex)

1.075 1 1.111 1 1.058 1 0.952 1 1.211 1 1.091 1 1.145 1 30 1 2 683.43994 19.72 56.52 1365.87261

LSSWVLLMK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 8 1 189163538 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.988 4 14.4 0.991 4 20.6 0.906 4 41.9 0.94 4 24.8 1.119 4 25.5 1.418 4 38 1.257 4 25.1 100 7.55 0 4 707.59039 -1.62 73.98 2827.33974

LSSWVLLMK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 2 1 189163538 N-Term(iTRAQ4plex); M8(Oxidation); K9(iTRAQ4plex)

0.705 5 15.2 0.989 5 12.1 0.709 5 20.4 0.678 5 25.3 0.856 5 15.4 0.728 5 5.3 1.098 5 5.5 87 7.75 0 3 748.09412 -0.37 30.99 2242.27091

LSWTADEGVFDNFVLK TNC tenascin precursor [Homo sapiens] 3371 NP_002151 2 1 153946395 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.134 1 0.932 1 0.992 1 1.065 1 1.198 1 1.285 1 1.207 1 86 6.22 0 3 554.27301 -0.18 15.42 1660.80448

LSWTVAQGPFDSFVVQYR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 1 188528648 N-Term(iTRAQ4plex) 0.84 1 0.789 1 0.725 1 0.919 1 0.778 1 0.986 1 1.073 1 59 6.07 0 3 787.06097 -1.59 32.19 2359.16837

LSYEGEVTK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 14 1 39725934 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.624 2 9.4 0.893 2 9.3 0.541 2 14.2 0.605 2 4.9 0.641 2 13.4 0.717 2 4.1 1.185 2 0.8 53 4.51 0 2 638.81812 -0.06 30.07 1276.62895

LSYTCEGGFR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 100 1 62739186 N-Term(iTRAQ4plex); C5(Methylthio)

0.338 1 0.962 1 0.663 1 0.689 1 51 9.59 0 4 832.68317 -1.7 42.13 3327.71084

LTCLQNLK CD55 complement decay-accelerating factor isoform 1 preproprotein [Homo sapiens]

1604 NP_000565 3 2 10835143 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

0.678 5 12 0.924 5 88.4 0.623 5 27.6 0.674 5 35.6 0.598 5 25.7 0.616 5 7.8 0.973 5 8 48 5.56 0 4 1166.54 2 71.36 3497.5978

LTCQVEHDGQPAVSK LOC100653194

PREDICTED: signal-regulatory protein beta-1 isoform 3-like isoform 7 [Homo sapiens]

100653194 XP_003403776 1 4 341914298 N-Term(iTRAQ4plex); C3(Methylthio); K15(iTRAQ4plex)

81 5.13 0 2 968.00342 2.84 49.09 1935.00017

LTEPADTITDAVK KLK1 kallikrein-1 preproprotein [Homo sapiens]

3816 NP_002248 2 1 4504875 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

68 4.38 0 2 743.86713 0.38 13.31 1486.72417

LTESLAMAPASAVSGLYFSNLK

MTR methionine synthase [Homo sapiens]

4548 NP_000245 1 1 169790923 N-Term(iTRAQ4plex); M7(Oxidation); K22(iTRAQ4plex)

61 4.01 0 2 725.41711 3.02 38.85 1449.82695

LTESYCETWR COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 2 2 110611233 N-Term(iTRAQ4plex); C6(Methylthio)

49 3.7 0 2 643.84924 0.57 31.15 1286.68901

LTFINDLCGPR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 14 3 221316614 N-Term(iTRAQ4plex); C8(Methylthio)

43 3.46 0 2 560.77948 1.13 22.95 1120.55168

LTGISDPVTVK OLFM1 noelin isoform 1 precursor [Homo sapiens]

10439 NP_055094 2 1 17136143 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.852 2 2.6 0.925 2 7.1 0.764 2 1.6 0.826 2 5.5 0.877 2 0.2 0.948 2 6.9 1.148 2 1.3 36 4.73 0 3 1125.0632 1.8 33.13 2249.11539

LTGSCSYVLFQNK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); C5(Methylthio); K13(iTRAQ4plex)

0.692 1 1.21 1 0.745 1 0.616 1 0.783 1 0.647 1 1.05 1 3.48 0 3 1125.0632 1.8 33.13 2265.11258

LTGSSGFVTDGPGNYK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 12 3 21450863 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.927 52 15.9 0.993 52 16 0.895 52 21.6 0.891 52 18 1.005 52 16.9 1.02 52 17.3 1.138 52 9.3 108 6.21 0 3 1001.5653 -3.89 38.13 2002.12571

LTIFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

0.971 4 17.4 0.934 4 1.2 0.876 4 25.6 0.96 4 24.2 0.981 4 11 1.075 4 15.7 1.187 4 6 105 7.92 0 3 1043.1198 3.35 80.44 3127.3447

LTIIVGPFSF EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 1 1 86788015 N-Term(iTRAQ4plex) 0.741 22 9 1.05 22 20 0.716 22 24.3 0.674 22 8.8 0.813 22 18.9 0.796 22 14.5 1.178 22 11.3 105 5.83 0 2 950.43933 0.34 24.38 1899.86907

LTISEQNIQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex) 0.833 14 9 1.058 14 14.1 0.87 14 20.6 0.764 14 12.9 0.94 14 10.2 0.885 14 14.2 1.141 14 11.5 101 8.64 0 3 1369.2026 2.05 62.95 2737.398

LTLDIQNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 20 1 105990532 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.907 21 11.2 0.955 21 17.5 0.832 21 12.9 0.84 21 12.2 0.964 21 17.3 0.989 21 14.7 1.159 21 15.1 96 10.13 0 3 873.15997 0.78 80.07 2617.46537

LTLEQIDLIR DPEP2 dipeptidase 2 precursor [Homo sapiens]

64174 NP_071750 1 1 11641269 N-Term(iTRAQ4plex) 0.84 41 13.5 0.879 41 13.9 0.739 41 16 0.85 41 18.8 0.839 41 16.7 0.937 41 16.5 1.136 41 12.2 93 5.76 0 3 867.96674 -1.95 47.54 1734.93425

LTLLAPLNSVFK TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 3 1 4507467 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.889 15 14.1 0.971 15 24.7 0.865 15 21.8 0.833 15 8.5 0.957 15 18.9 0.932 15 5.8 1.119 15 4.2 92 4.43 0 2 707.85254 -8.14 23.61 1414.70683

LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPR

CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

2 1 256217721 N-Term(iTRAQ4plex) 0.956 12 16.6 0.868 12 29.9 0.81 12 36.1 0.882 12 21.7 0.998 12 25.5 1.106 12 48.7 1.229 12 44.8 78 8.38 1 4 1041.566 3.23 55.84 3122.68813

LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPR

CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

4 1 256217721 N-Term(iTRAQ4plex); M7(Oxidation)

0.645 3 13.8 1.125 3 2.7 0.653 3 11.8 0.581 3 9.1 0.718 3 18.4 0.638 3 5.3 1.148 3 5.2 75 5.62 0 3 790.86395 -5.68 19.25 1580.73502

LTLQGIISWGSGCGDR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 18 1 145275213 N-Term(iTRAQ4plex); C13(Methylthio)

0.901 4 3.4 0.853 4 5 0.759 4 4.4 0.893 4 9.5 0.907 4 2 1.049 4 6.9 1.203 4 3.4 70 3.87 0 3 478.61246 -0.36 32.65 1433.82758

LTLTCK CRISP3 cysteine-rich secretory protein 3 isoform 1 precursor [Homo sapiens]

10321 NP_006052 1 2 300244560 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

0.825 24 14 1.027 24 14.9 0.81 24 21.3 0.81 24 13.3 0.924 24 15.1 0.922 24 14.8 1.131 24 6.4 67 3.87 0 2 660.90851 -2.44 26.2 1320.81279

LTLTPWVGLR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 2 3 21450863 N-Term(iTRAQ4plex) 0.776 13 13 0.872 13 23.1 0.695 13 26.7 0.747 13 17.2 0.854 13 27.4 0.913 13 16.4 1.229 13 20.3 64 5.68 0 3 1088.5718 -2.49 49.93 2176.13628

LTMQNLNDR KRT19 keratin, type I cytoskeletal 19 [Homo sapiens]

3880 NP_002267 1 1 24234699 N-Term(iTRAQ4plex) 0.821 11 5.4 0.978 11 12.7 0.749 11 10.2 0.79 11 10.5 0.887 11 8.2 0.88 11 4.3 1.131 11 8.3 63 4.91 0 2 759.32721 -0.66 35.85 1517.64714

LTPEEIER HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 1 1 16507237 N-Term(iTRAQ4plex) 0.797 12 20.4 1.078 12 36.6 0.69 12 35.4 0.624 12 19.6 0.947 12 26 0.826 12 13.8 1.346 12 20.4 60 8.82 1 4 925.19342 0.46 66.86 2773.56681

LTPLYELVK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 23 1 45580688 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.706 9 10.9 1.052 9 24.3 0.696 9 18.9 0.62 9 8.8 0.786 9 26.1 0.719 9 3.9 1.142 9 4.9 59 3.79 0 2 712.36957 -2.23 28.9 1423.73723

LTPYADEFK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 59 1 71773110 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.913 4 9.5 0.966 4 7.4 0.829 4 17.3 0.859 4 9.7 0.964 4 13.3 0.998 4 10.4 1.107 4 6.5 55 4.98 1 3 530.65125 9.26 25.39 1589.93753

LTQLGTFEDHFLSLQR EGFR epidermal growth factor receptor isoform b precursor [Homo sapiens]

1956 NP_958439 2 4 41327732 N-Term(iTRAQ4plex) 0.798 16 8.1 0.934 16 13.8 0.734 16 12.1 0.768 16 10 0.847 16 9.1 0.875 16 12.7 1.138 16 2.7 54 3.23 0 2 560.87225 3.54 35.95 1120.73174

LTQLNLDR GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 2 1 291190772 N-Term(iTRAQ4plex) 0.668 3 13.3 1.017 3 5.7 0.671 3 3 0.673 3 0.2 0.704 3 17.2 0.776 3 1.6 1.153 3 1.4 54 3.6 0 2 671.89789 -3.58 19.85 1342.7885

LTQVEHR SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 3 1 39725934 N-Term(iTRAQ4plex) 0.904 2 1.6 0.923 2 2.2 0.803 2 1.1 0.87 2 3.3 0.935 2 0 1.014 2 2.2 1.165 2 1.1 49 3.07 0 2 566.32977 0.84 13.01 1131.65227

LTSLPLGALR GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 4 1 291190772 N-Term(iTRAQ4plex) 0.809 3 7.6 0.968 3 0.9 0.748 3 12.3 0.772 3 13.2 0.845 3 2.5 0.873 3 3.5 1.13 3 7.4 49 5.4 1 3 1224.6707 -1.92 40.53 2448.3389

LTSLSDR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex) 0.906 1 1.21 1 0.952 1 0.787 1 1.051 1 0.869 1 1.104 1 48 2.95 0 2 712.36957 -2.23 28.9 1439.72502

LTVAAPPSGGPGFLSIERPDSRPPR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

108 6 178557739;67190748

N-Term(iTRAQ4plex) 0.632 9 15.8 0.857 9 19.7 0.547 9 26.1 0.625 9 8.1 0.648 9 19.9 0.735 9 4.2 1.15 9 4.5 48 3.28 0 2 634.82245 -2.67 41.59 1268.63762

LTVGAAQVPAQLLVGALR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 6 1 4557417 N-Term(iTRAQ4plex) 0.847 2 8 1.043 2 9.4 0.804 2 13.1 0.771 2 3.6 0.928 2 12.7 0.89 2 3.3 1.154 2 0.3 46 3.28 0 2 559.80859 1.32 14.19 1118.60393

LTVGLTR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

1 5 47132549;16933542

N-Term(iTRAQ4plex) 0.484 30 26.4 1.033 30 15.9 0.477 29 46.6 0.477 29 29.1 0.51 30 27.5 0.499 30 21.9 1.119 29 15.3 46 7.25 0 4 1173.5396 2.96 59.63 3518.59463

LTVSIEAR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

12 1 256217721 N-Term(iTRAQ4plex) 0.902 2 27.3 0.991 2 23.1 0.832 2 47.6 0.84 2 22.7 0.967 2 32.9 0.976 2 9.2 1.162 2 13.2 43 3.83 0 2 655.849 8.23 16.51 1310.69072

LTWTNPSIK IL6ST interleukin-6 receptor subunit beta isoform 1 precursor [Homo sapiens]

3572 NP_002175 2 3 28610147 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.882 3 12.3 1.144 3 3.9 0.938 3 4.1 0.843 3 1.2 0.98 3 15.8 0.952 3 10 1.13 3 8.8 43 3.03 0 2 526.79541 0.87 7.5 1052.58354

LTYTNWNEGEPNNAGSDEDCVLLLK

MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 2 1 4557739 N-Term(iTRAQ4plex); C20(Methylthio); K25(iTRAQ4plex)

2.362 9 11.4 0.994 9 35.8 2.227 9 32.3 2.128 9 27.6 2.864 9 22.1 2.35 9 26.9 1.219 9 14 40 6.79 0 4 1173.5396 2.96 59.63 3534.58803

LVAYYTLIGASGQR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 40 1 115298678 N-Term(iTRAQ4plex) 0.609 2 13.1 0.815 2 31.3 0.522 2 30.7 0.641 2 0.6 0.588 2 24.2 0.722 2 6.7 1.126 2 6.2 39 3.79 0 2 660.76923 1.27 14.2 1320.53118

LVCPADNLR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex); C3(Methylthio)

0.823 1 1.054 1 0.742 1 0.704 1 0.949 1 0.9 1 1.279 1 38 0 2 556.28192 -14.78 17.18 1111.55657

LVDEDMNSFK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 34 1 133925809 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.755 5 18 0.971 5 12.3 0.734 5 15.4 0.696 5 3.7 0.818 5 28.1 0.776 5 10.2 1.114 5 3.6 38 3.15 0 2 580.75543 7.82 23.92 1160.49541

LVDEDMNSFK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 10 1 133925809 N-Term(iTRAQ4plex); M6(Oxidation); K10(iTRAQ4plex)

0.844 6 6.2 0.832 6 39 0.707 6 23.8 0.845 6 9 0.815 6 20.3 1.002 6 13.2 1.176 6 2.5 36 0 2 608.29279 0.7 12.33 1215.57829

LVDFLSR COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 1 3 55743098 N-Term(iTRAQ4plex) 0.763 4 16.1 0.997 4 3.1 0.713 4 6.5 0.73 4 13.5 0.795 4 11.2 0.814 4 15.4 1.106 4 3.2 35 0 2 536.77753 -10.21 14.73 1072.54778

LVDFYVMPVVNVDGYDYSWK

CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 15 1 126273569 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

0.659 1 0.981 1 0.565 1 0.576 1 0.74 1 0.755 1 1.31 1 34 4.41 0 3 438.56711 -6.16 18.11 1313.68677

LVDFYVMPVVNVDGYDYSWK

CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 2 1 126273569 N-Term(iTRAQ4plex); M7(Oxidation); K20(iTRAQ4plex)

0.877 1 0.983 1 0.848 1 0.862 1 0.891 1 0.906 1 1.051 1 30 0 3 427.88278 -1.43 14.98 1281.63379

LVDGVTECSGR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C8(Methylthio)

0.242 1 0.789 1 0.199 1 0.253 1 0.235 1 0.297 1 1.177 1 29 2.93 0 2 608.29279 0.7 12.33 1199.59429

LVDQDK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 1 1 119392081 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.784 1 0.961 1 0.786 1 0.818 1 0.751 1 0.782 1 0.955 1 27 7.17 1 4 584.61328 1.98 53.7 2335.4313

LVEENALAPDFSK MMRN1 multimerin-1 precursor [Homo sapiens]

22915 NP_031377 4 1 45269141 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.751 1 0.952 1 0.724 1 0.76 1 0.742 1 0.78 1 1.026 1 3.76 1 3 475.58633 1.63 27.12 1424.74445

LVELAHQYK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.8 3 6.2 0.969 3 12.5 0.774 3 5.8 0.768 3 0.6 0.838 3 13 0.862 3 12 1.122 3 7.9 2.95 0 2 547.2771 3.14 38.81 1093.54692

LVFQQFDLEPSEGCFYDYVK

C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

30 1 66347875 N-Term(iTRAQ4plex); C14(Methylthio); K20(iTRAQ4plex)

0.422 2 10.6 0.839 2 50.2 0.365 2 36.9 0.435 2 11.7 0.421 2 29.8 0.502 2 18.4 1.154 2 6.5 49 3.18 0 2 634.36255 3.29 20.26 1267.71782

LVGFIDDAVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.336 4 7.5 0.929 4 14.3 1.121 4 15.4 1.304 4 2.8 1.404 4 6.5 1.511 4 4.1 1.198 4 9 102 6.01 0 3 1122.9347 -1 45.02 2244.86313

LVGGDNLCSGR CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 4 1 5174411 N-Term(iTRAQ4plex); C8(Methylthio)

1.332 5 9.6 0.941 5 6.1 1.215 5 8.8 1.217 5 4.1 1.37 5 10.1 1.45 5 9.3 1.123 5 3.6 100 6.12 0 2 1075.0641 5.96 41.12 2149.1209

LVGGPMDASVEEEGVR CST3 cystatin-C precursor [Homo sapiens]

1471 NP_000090 7 1 4503107 N-Term(iTRAQ4plex) 1.717 2 84.7 0.841 2 1.1 1.42 2 99.8 1.688 2 97.9 1.736 2 74.7 2.064 2 73.1 1.223 2 16.7 95 4.06 0 3 1122.9347 -1 45.02 2260.86087

LVGGPMDASVEEEGVR CST3 cystatin-C precursor [Homo sapiens]

1471 NP_000090 6 1 4503107 N-Term(iTRAQ4plex); M6(Oxidation)

1.345 7 20.7 0.894 7 11.1 1.196 7 37.8 1.245 7 22.7 1.453 7 19.6 1.507 7 39.5 1.211 7 11.5 91 6.55 1 3 1259.022 -9.82 24.89 2517.03385

LVGGPMDASVEEEGVRR CST3 cystatin-C precursor [Homo sapiens]

1471 NP_000090 6 1 4503107 N-Term(iTRAQ4plex); M6(Oxidation)

1.274 28 11.9 0.987 28 18 1.211 28 18.4 1.212 28 12.2 1.349 28 15 1.337 28 10.3 1.132 28 7.6 90 5.5 0 3 993.51196 -2.7 61.88 1986.02304

Page 28: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

LVGITSWGEGCAR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 20 1 78191798 N-Term(iTRAQ4plex); C11(Methylthio)

1.703 4 11.8 1.137 4 4.5 1.724 4 4.7 1.516 4 2.3 1.916 4 20 1.703 4 14.8 1.243 4 10.5 88 7.82 0 3 848.75934 -0.79 39.37 2544.26346

LVHCPIETQVLR RARRES2 retinoic acid receptor responder protein 2 precursor [Homo sapiens]

5919 NP_002880 4 1 4506427 N-Term(iTRAQ4plex); C4(Methylthio)

1.48 4 9.8 0.911 4 7.9 1.336 4 10.7 1.44 4 4.4 1.522 4 15.1 1.666 4 8.3 1.171 4 5.5 87 5.38 0 3 1075.0641 5.96 41.12 2165.11576

LVHVEEPHTETVR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex) 1.281 241 11.2 0.98 241 12.3 1.19 241 14.7 1.218 241 12.5 1.32 241 14.4 1.373 241 15 1.128 241 7.7 85 5.94 0 3 848.98395 -3.49 52.73 1696.9636

LVLLNAIYLSAK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 166 1 73858568 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.267 29 5.6 0.976 29 7.6 1.17 29 6 1.199 29 7.6 1.332 29 8.2 1.391 29 10.2 1.1 29 7.7 82 5.01 0 2 921.41272 0.8 48.36 1841.81816

LVLQFK OLFM1 noelin isoform 1 precursor [Homo sapiens]

10439 NP_055094 1 1 17136143 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.475 8 7.2 1.06 8 13.2 1.377 8 17.2 1.295 8 8.7 1.672 8 3.9 1.499 8 7.5 1.233 8 8.6 81 5.41 0 3 968.93738 -5.47 40.5 1936.87333

LVMGIPTFGR CHI3L1 chitinase-3-like protein 1 precursor [Homo sapiens]

1116 NP_001267 2 1 144226251 N-Term(iTRAQ4plex) 1.295 16 11.4 0.978 16 14.3 1.201 16 19.6 1.181 16 11.8 1.367 16 11.9 1.376 16 10.7 1.142 16 5.6 81 6.01 0 2 803.87469 5.57 17.15 1606.72978

LVNGQSHISLSK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

4 6 178557739;67190748

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.085 2 10.6 0.922 2 12 0.999 2 18.9 1.084 2 6.7 1.088 2 14.1 1.18 2 2.1 1.089 2 4.7 80 6.84 0 3 848.75934 -0.79 39.37 2528.2703

LVNIAVDER CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 1 2 330688397 N-Term(iTRAQ4plex) 1.356 4 29.1 0.846 4 7.6 1.23 4 26.7 1.392 4 48.1 1.324 4 13.3 1.499 4 34.4 1.076 4 10.5 77 6.25 1 2 1259.022 -9.82 24.89 2501.07036

LVNIYDSMPLR EXTL2 exostosin-like 2 [Homo sapiens] 2135 NP_001430 1 1 14149609 N-Term(iTRAQ4plex) 1.151 1 0.967 1 1.077 1 1.114 1 1.187 1 1.227 1 1.102 1 77 5.34 1 2 939.96936 0.67 16.58 1878.93144LVPFATELHER APOA4 apolipoprotein A-IV precursor

[Homo sapiens]337 NP_000473 39 1 71773110 N-Term(iTRAQ4plex) 1.241 6 2.5 0.918 6 8.9 1.146 6 3.6 1.202 6 9.8 1.29 6 5.6 1.346 6 1.5 1.13 6 8.3 70 5.47 0 2 1027.0145 0.1 32.14 2053.02178

LVPNPGQEDADRDGVGDVCQDDFDADK

COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 2 1 40217843 N-Term(iTRAQ4plex); C19(Methylthio); K27(iTRAQ4plex)

2.717 2 22.6 0.954 2 21.6 2.765 2 21.7 2.899 2 0.1 2.541 2 47.4 2.664 2 24 0.919 2 23.8 67 5.49 1 3 1259.022 -9.82 24.89 2533.05979

LVPPMEEDYPQFGSPK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 9 2 115583663 N-Term(iTRAQ4plex); M5(Oxidation); K16(iTRAQ4plex)

1.032 1 0.972 1 0.978 1 1.006 1 1.057 1 1.087 1 1.081 1 61 4.12 0 2 1122.9347 -1 45.02 2228.86846

LVPPMEEDYPQFGSPK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 5 2 115583663 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.276 2 4.3 1.121 2 6.6 1.361 2 7 1.214 2 0.4 1.341 2 8.7 1.197 2 15.4 0.986 2 15.8 60 7.55 1 3 864.46796 0.54 61.27 2591.38932

LVSEDPINDGEWHR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex) 1.253 33 6.7 0.982 33 9.3 1.16 33 11 1.173 33 7.8 1.321 33 9 1.33 33 7.2 1.135 33 5.4 56 4.87 0 3 449.5853 0.6 48.58 1346.74134

LVSLDSGLLNSLGALTELQFHR

GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 24 1 4758460 N-Term(iTRAQ4plex) 1.309 9 7.5 0.95 9 9.7 1.234 9 10 1.272 9 4.8 1.382 9 3.4 1.422 9 5.3 1.09 9 5.4 43 3.48 0 2 583.32123 1.53 42.88 1165.63518

LVSVPYVGGNMEVNVYGAIMHEVR

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex) 1.257 1 0.775 1 1.113 1 1.435 1 1.119 1 1.444 1 1.006 1 39 3.93 0 3 806.09827 -0.34 43.81 2416.28025

LVSVPYVGGNMEVNVYGAIMHEVR

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); M11(Oxidation)

1.08 5 1.9 0.927 5 5.6 0.988 5 11.8 1.043 5 6.4 1.087 5 10.5 1.172 5 3.2 1.11 5 1.7 30 2.92 0 2 544.7298 4.17 34.21 1088.45232

LVVLPFPK FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 19 1 58331240 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.457 3 5.1 1.2 3 2.7 1.483 3 8.2 1.282 3 5.5 1.672 3 14 1.531 3 16.7 1.239 3 10.3 4.53 1 3 962.82153 1.44 44.14 2886.45005

LVVQSSIDSSAFK KIT mast/stem cell growth factor receptor Kit isoform 2 precursor [Homo sapiens]

3815 NP_001087241 2 2 148005039 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.039 2 19.5 1.145 2 30.5 1.064 2 2.5 0.929 2 33.2 1.176 2 4.2 1.027 2 35 1.105 2 1.7 35 4.65 0 3 1054.2057 4.75 58.32 3160.60251

LVWEEAMSR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 4 2 221316614 N-Term(iTRAQ4plex) 1.214 1 0.903 1 1.043 1 1.155 1 1.266 1 1.402 1 1.214 1 46 3.4 0 2 624.34882 0.39 30.16 1247.69036

LVWEEAMSR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 1 2 221316614 N-Term(iTRAQ4plex); M7(Oxidation)

1.195 1 0.978 1 1.175 1 1.201 1 1.188 1 1.215 1 1.012 1 41 0 2 624.34882 0.39 30.16 1263.68535

LVYHLGLPFSFLTFPYVEEAIK

SEPP1 selenoprotein P isoform 1 precursor [Homo sapiens]

6414 NP_005401 24 2 62530391 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.381 1 0.837 1 1.176 1 1.404 1 1.362 1 1.627 1 1.159 1 3.21 0 2 561.82306 0.04 18.36 1122.63884

LVYPSCEEK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 17 1 5031695 N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

1.39 35 12.6 0.986 35 18.5 1.268 35 20.4 1.351 35 7.4 1.517 35 17.9 1.493 35 6.5 1.12 35 4.8 100 4.94 0 2 841.45673 3.69 42.54 1681.90618

LWAYLTIEQLLEK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 120 1 133925809 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.425 15 5.1 0.98 15 10.8 1.357 15 9.3 1.371 15 12.8 1.446 15 13 1.504 15 4.4 1.095 15 4.6 68 4.79 0 2 775.88477 -6.28 27.76 1550.77251

LWAYLTINQLLAER ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 8 1 70778918 N-Term(iTRAQ4plex) 1.347 3 5 0.75 3 31.7 1.082 3 14.6 1.527 3 7.9 1.197 3 1.4 1.682 3 7.9 1.106 3 0.6 56 4.44 0 2 727.89569 -2.83 16.43 1454.78411

LWAYLTIQELLAK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 204 3 156119625 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.391 19 7.5 0.976 19 7.2 1.311 19 12.2 1.328 19 8.1 1.413 19 11.9 1.466 19 9.1 1.107 19 3.2 55 4.64 0 2 650.85425 -0.44 26.2 1300.70171

LWAYLTIQQLLEQTVSASDADQQALR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

12 2 31542984;262050538

N-Term(iTRAQ4plex) 1.41 31 9.3 0.999 31 12.9 1.367 31 16.9 1.322 31 9.1 1.538 31 14.9 1.482 31 5.9 1.131 31 5.8 53 4.77 0 3 787.99927 -0.02 51.6 1574.99101

LWLEGNPWDCGCPLK IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 28 2 4826772 N-Term(iTRAQ4plex); C10(Methylthio); C12(Methylthio); K15(iTRAQ4plex)

1.352 20 19 0.991 20 19.9 1.261 20 16 1.384 20 10.6 1.375 20 17.2 1.573 20 15.9 1.114 20 6.5 51 3.94 0 2 641.3725 6.57 19.65 1281.72722

LWLHVLPTLPGTLCLR INHBE inhibin beta E chain precursor [Homo sapiens]

83729 NP_113667 2 1 13899338 N-Term(iTRAQ4plex); C14(Methylthio)

1.468 4 5.7 0.935 4 18.7 1.356 4 11.8 1.513 4 3.3 1.489 4 7.7 1.729 4 3.3 1.131 4 1.6 34 0 2 478.25241 1.05 12.02 955.49755

LWWLDLK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 282 1 11321561 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.704 120 35.9 0.96 120 15.4 0.652 120 33.8 0.675 120 36.3 0.737 120 36.9 0.784 120 40.6 1.182 120 16.3 98 7.96 0 3 876.42633 1.23 74 2627.26444

LYDYCDVPQCAAPSFDCGKPQVEPK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 29 1 4505881 N-Term(iTRAQ4plex); C5(Methylthio); C10(Methylthio); C17(Methylthio); K19(iTRAQ4plex); K25(iTRAQ4plex)

0.986 13 38.7 0.964 14 28 0.868 13 46.2 0.884 13 26.2 1.042 12 53.2 1.103 12 41.2 1.028 12 33.5 79 7.75 1 3 934.50592 2.41 80.57 2801.50339

LYGSEAFATDFQDSAAAK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 473 1 50659080 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

0.54 7 11.4 0.894 7 21.9 0.523 7 17.5 0.568 7 8.1 0.614 7 7.5 0.628 7 21.1 1.195 7 3 62 3.8 0 2 615.38947 0.71 18.18 1229.76323

LYGSEAFATDFQDSAAAKKLINDYVK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 1 1 50659080 N-Term(iTRAQ4plex); K18(iTRAQ4plex); K19(iTRAQ4plex); K26(iTRAQ4plex)

0.661 17 13.3 1.036 17 8.6 0.646 17 16.2 0.612 17 6.2 0.729 17 15.7 0.686 17 5.7 1.136 17 4.9 56 4.2 0 2 630.85535 -0.33 14.59 1260.70342

LYHIQGIEGQSVEVSNIVDIR MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 2 1 51477714 N-Term(iTRAQ4plex) 1.267 3 45.9 1.109 2 64.5 0.643 3 10 0.97 2 27.7 0.89 3 55.4 1.369 2 20.4 1.346 3 14.1 56 5.29 0 3 843.77551 4.97 81.21 2529.31198

LYLVQGTQVYVFLTK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 1020 1 11321561 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.538 1 0.917 1 0.48 1 0.523 1 0.551 1 0.601 1 1.148 1 52 4.36 1 2 795.00116 -3.02 16.87 1588.99504

LYLVQGTQVYVFLTKGGYTLVSGYPK

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 10 1 11321561 N-Term(iTRAQ4plex); K15(iTRAQ4plex); K26(iTRAQ4plex)

0.663 1 1.036 1 0.623 1 0.601 1 0.726 1 0.701 1 1.166 1 40 5.23 1 3 544.66119 -0.15 15.35 1631.96903

LYPGDAVSLQGAARDMLSALYR

CHST2 carbohydrate sulfotransferase 2 [Homo sapiens]

9435 NP_004258 3 1 27369497 N-Term(iTRAQ4plex); M16(Oxidation)

0.761 3 5 1.041 3 10.8 0.74 3 6.6 0.711 3 4.2 0.812 3 14.2 0.798 3 3.3 1.154 3 7.1 32 0 2 481.26303 -4.7 17.72 961.51879

LYPVWK GPNMB transmembrane glycoprotein NMB isoform b precursor [Homo sapiens]

10457 NP_002501 1 2 4505405 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.189 7 8.8 0.989 7 24.6 1.153 7 22.8 1.101 7 8.2 1.251 7 21.9 1.2 7 4.1 1.086 7 4.7 57 4.54 0 2 745.37885 -4.14 34.44 1489.75041

LYQPEYQEVSTEEQREEISGK

HYOU1 hypoxia up-regulated protein 1 precursor [Homo sapiens]

10525 NP_006380 2 1 5453832 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

0.967 1 1.075 1 0.929 1 0.864 1 1.077 1 1.003 1 1.16 1 57 3.45 0 2 670.8504 -0.1 19.71 1340.69353

LYTVDLESGLHYLLR QSOX2 sulfhydryl oxidase 2 precursor [Homo sapiens]

169714 NP_859052 2 1 145580631 N-Term(iTRAQ4plex) 1.017 1 0.863 1 0.889 1 1.029 1 1.007 1 1.166 1 1.133 1 34 2.86 1 2 896.95117 1.08 23.62 1792.89507

LYWDDLK TFRC transferrin receptor protein 1 [Homo sapiens]

7037 NP_003225 1 1 189458817 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.36 2 3.4 1.156 2 35.3 1.284 2 17.4 1.111 2 17.1 1.668 2 25.6 1.443 2 9.1 1.299 2 7.9 66 4.9 0 3 853.3891 -3.04 19.83 1705.77243

LYYGDDEK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 4 1 4557389 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.749 2 11.8 0.951 2 2.3 0.68 2 10.8 0.715 2 8.5 0.781 2 14.8 0.821 2 12.5 1.148 2 4 48 3.43 0 2 608.85309 -2.4 23.33 1216.6989

LYYLNGIECAASAMEMSAIAAHNAALLAYHR

PCYOX1 prenylcysteine oxidase 1 precursor [Homo sapiens]

51449 NP_057381 2 1 166795301 N-Term(iTRAQ4plex); C9(Methylthio)

0.886 2 22.2 1.017 2 5 0.82 2 21.2 0.806 2 16.1 0.967 2 27.9 0.951 2 22.7 1.18 2 6.5 45 4.7 0 2 922.43701 -0.32 73.81 1843.86675

MAAAAAAAAAAGAAGGRGSGPGR

PABPN1 polyadenylate-binding protein 2 [Homo sapiens]

8106 NP_004634 1 1 4758876 M1(Oxidation); N-Term(iTRAQ4plex)

0.934 2 4.9 1.105 2 1.2 0.938 2 4.5 0.849 2 3.2 1.029 2 6.6 0.931 2 5.4 1.097 2 2.1 40 3.25 0 2 584.83246 -2.44 30.45 1168.6613

MAAGSAPMQLHLR APOM apolipoprotein M isoform 2 [Homo sapiens]

55937 NP_001243098 2 1 371873523 N-Term(iTRAQ4plex) 1.623 1 0.805 1 1.376 1 1.709 1 1.553 1 1.929 1 1.129 1 84 4.76 0 2 785.38684 -0.87 21.47 1569.76641

MADEAGSEADHEGTHSTK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 M1(Oxidation); N-Term(iTRAQ4plex); K18(iTRAQ4plex)

2.568 1 1.011 1 2.433 1 2.406 1 2.731 1 2.701 1 1.123 1 77 3.75 0 2 856.47321 -4.55 22.08 1711.93913

MAESGYDIALLK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 3 1 4503627 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.346 1 0.964 1 1.281 1 1.329 1 1.363 1 1.414 1 1.064 1 50 3.85 0 2 759.93237 -10.24 20.9 1518.85747

MAGTNALLMLENFIDGK ALDH8A1 aldehyde dehydrogenase family 8 member A1 isoform 2 [Homo sapiens]

64577 NP_739577 1 3 25952152 M1(Oxidation); N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.231 2 52.5 0.995 2 17.5 1.151 2 42.9 1.157 2 63.8 1.309 2 42.1 1.315 2 62.9 1.137 2 0.7 65 6.24 0 3 993.52814 -2.26 41.13 1986.04667

MALEVYK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 6 1 4502503 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.822 1 0.865 1 1.605 1 1.855 1 1.794 1 2.073 1 1.118 1 3.51 0 3 562.64783 0.09 22.3 1685.92893

MAPEEIIMDRPFLFVVR SERPINE1 plasminogen activator inhibitor 1 isoform 2 precursor [Homo sapiens]

5054 NP_001158885 6 2 259155306 N-Term(iTRAQ4plex) 1.442 119 13.8 0.934 119 21.6 1.3 119 18.6 1.432 119 18.4 1.508 119 20.5 1.591 119 16.7 1.117 119 17.1 115 9.19 0 4 1274.1588 -0.39 59.67 2547.31035

MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGK

SUZ12 polycomb protein SUZ12 [Homo sapiens]

23512 NP_056170 1 1 197333809 M1(Oxidation); N-Term(iTRAQ4plex); K5(iTRAQ4plex); K40(iTRAQ4plex)

1.384 30 16 0.99 30 12.2 1.32 30 17.5 1.322 30 14.1 1.441 30 18.1 1.47 30 14.1 1.117 30 3.4 89 4.96 0 2 848.97278 -1.01 56.77 1696.93828

MATTMIQSK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 5 1 70778918 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.469 14 8 0.918 14 21.8 1.336 14 14.5 1.414 14 7.3 1.509 14 17.5 1.653 14 13.3 1.136 14 10.9 84 7.31 0 4 1032.5491 -2.71 15.53 2064.09087

MATTMIQSK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 12 1 70778918 M1(Oxidation); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.467 38 13.6 0.851 38 22.3 1.324 38 18.4 1.467 38 14 1.485 38 16 1.681 38 10.2 1.123 38 4.9 69 5.19 0 3 1036.0796 2.5 46.76 2071.14433

MATTMIQSK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 1 1 70778918 M1(Oxidation); N-Term(iTRAQ4plex); M5(Oxidation); K9(iTRAQ4plex)

1.47 5 3.7 1.016 5 4.1 1.411 5 3.8 1.371 5 5.8 1.557 5 7.2 1.526 5 7.8 1.129 5 2.2 66 6.21 1 2 1075.5457 1.58 28.1 2150.07793

MCPQLQQYEMHGPEGLR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 24 1 66932947 N-Term(iTRAQ4plex); C2(Methylthio)

1.491 17 10 1.021 17 11.7 1.441 17 17.8 1.369 17 8 1.58 17 11.5 1.54 17 7.7 1.099 17 3.7 63 4.71 0 2 705.35028 -2.9 19.75 1409.69963

MCPQLQQYEMHGPEGLR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 8 1 66932947 N-Term(iTRAQ4plex); C2(Methylthio); M10(Oxidation)

1.397 24 6.8 0.916 24 12.4 1.261 24 15.8 1.343 24 6.6 1.428 24 15.2 1.55 24 9 1.138 24 7 62 4.95 0 2 792.88049 1.15 43.44 1584.74993

MCSFPFVK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 2 1 13540563 N-Term(iTRAQ4plex); C2(Methylthio); K8(iTRAQ4plex)

1.545 15 14.5 1.017 15 16.2 1.473 15 21.5 1.48 15 7.8 1.702 15 16.3 1.679 15 9.3 1.124 15 6.3 59 3.97 0 2 707.37811 -3.45 31.53 1413.75212

MCVDVNECQR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

6 4 34734066;34734062

N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio)

1.417 40 11.7 1.005 40 11.7 1.321 40 11.8 1.328 40 10.7 1.458 40 12.9 1.465 40 12 1.108 40 3.6 58 4.1 0 2 755.86688 -3.18 38.95 1510.72466

MCVDVNECQR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

3 4 34734066;34734062

M1(Oxidation); N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio)

1.317 8 12.7 1.015 8 4 1.227 8 19.4 1.262 7 8.7 1.41 8 9.6 1.365 8 12 1.133 8 7.1 53 5.44 1 3 547.63232 -5.88 23.9 1640.89396

MCVKLLPLGATDTAVFDVR MVB12A multivesicular body subunit 12A [Homo sapiens]

93343 NP_612410 10 1 24308440 N-Term(iTRAQ4plex); C2(Methylthio); K4(iTRAQ4plex)

1.349 9 1.6 0.931 9 10.9 1.269 9 12.5 1.335 9 3.1 1.396 9 6.9 1.498 9 6.8 1.104 9 0.9 53 4.15 0 3 474.24915 -0.91 37.01 1420.73288

MDDAVAPGR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 1 1 105990535 M1(Oxidation); N-Term(iTRAQ4plex)

1.323 21 16.6 1.061 21 8.7 1.293 21 17.1 1.22 21 16.2 1.431 21 15.2 1.401 21 19.8 1.151 21 1.4 51 3.55 0 2 608.82611 -0.23 25.06 1216.64311

MDDAVAPGR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 6 1 105990535 N-Term(iTRAQ4plex) 1.405 10 4.6 0.989 10 11.1 1.292 10 11.7 1.415 10 6.8 1.458 10 10.4 1.634 10 7.6 1.145 10 2.5 49 4.15 0 2 636.33844 -1.3 29.43 1271.6696

MDELRPLIPVLEEYK OLFM1 noelin isoform 1 precursor [Homo sapiens]

10439 NP_055094 2 1 17136143 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.226 2 7.3 1.127 2 7.4 1.212 2 4.5 1.075 2 11.8 1.396 2 2.4 1.239 2 9.8 1.152 2 2 45 5.23 1 3 607.66522 -4.76 17.29 1820.98111

MDILSYMR GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 8 1 6006001 N-Term(iTRAQ4plex) 1.727 2 2.6 1.036 2 10.1 1.652 2 3.2 1.594 2 7 1.866 2 2 1.801 2 8.1 1.129 2 1.2 45 2.99 0 2 705.35028 -2.9 19.75 1425.6906

MDILSYMR GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 2 1 6006001 M1(Oxidation); N-Term(iTRAQ4plex)

1.725 1 0.914 1 1.539 1 1.684 1 1.762 1 1.928 1 1.145 1 45 0 2 707.37811 -3.45 31.53 1429.74492

MDMTFSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 M1(Oxidation); N-Term(iTRAQ4plex); M3(Oxidation); K7(iTRAQ4plex)

1.492 6 8.7 1.021 6 17.3 1.4 6 24.5 1.421 6 5.7 1.484 6 15.5 1.564 6 6 1.123 6 4.1 44 3.13 0 2 567.82104 -0.81 8.06 1134.63555

MDSQQVWDR ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 3 preproprotein [Homo sapiens]

11093 NP_620595 2 3 21265043 N-Term(iTRAQ4plex) 1.63 2 4.2 1.101 2 8.6 1.614 2 10.9 1.466 2 2.3 1.811 2 6.8 1.645 2 1.8 1.122 2 4.1 43 3.23 0 2 535.79401 -6.16 20.81 1070.58074

MDVFSQNMFCAGHPSLK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

2 1 66347875 N-Term(iTRAQ4plex); C10(Methylthio); K17(iTRAQ4plex)

1.292 2 4.9 0.822 2 5.3 1.077 2 2.5 1.31 2 2.8 1.276 2 6.7 1.552 2 12.1 1.185 2 9.3 39 0 3 357.53302 -1.74 17.07 1070.58451

MDVFSQNMFCAGHPSLK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

4 1 66347875 N-Term(iTRAQ4plex); M8(Oxidation); C10(Methylthio); K17(iTRAQ4plex)

1.381 2 6.8 1.022 2 16 1.336 2 18.6 1.307 2 2.6 1.459 2 11.6 1.428 2 4.3 1.093 2 6.9 37 0 2 559.79462 -6.98 18.69 1118.58196

MDVFSQNMFCAGHPSLK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

2 1 66347875 M1(Oxidation); N-Term(iTRAQ4plex); M8(Oxidation); C10(Methylthio); K17(iTRAQ4plex)

1.652 1 1.021 1 1.573 1 1.541 1 1.766 1 1.729 1 1.122 1 36 0 2 548.78003 -2.31 15.39 1096.55278

MDWLVPATCEPIQSVFFFSGDK

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 53 1 88853069 N-Term(iTRAQ4plex); C9(Methylthio); K22(iTRAQ4plex)

1.491 1 0.913 1 1.298 1 1.422 1 1.555 1 1.703 1 1.198 1 34 1 2 547.63232 -5.88 23.9 1656.87932

MDWLVPATCEPIQSVFFFSGDK

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 56 1 88853069 M1(Oxidation); N-Term(iTRAQ4plex); C9(Methylthio); K22(iTRAQ4plex)

0.948 1 1.047 1 0.908 1 0.867 1 1.032 1 0.986 1 1.137 1 79 4.05 0 2 811.40277 0.61 33.58 1621.79827

MEEVEAMLLPETLK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 181 1 50659080 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.547 30 11.4 0.956 30 6.1 1.44 30 9.4 1.527 30 12.7 1.6 30 10.8 1.71 30 13.9 1.132 30 3.7 88 5.24 0 2 857.89435 0.92 35.87 1714.77764

MEEVEAMLLPETLK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 33 1 50659080 N-Term(iTRAQ4plex); M7(Oxidation); K14(iTRAQ4plex)

1.9 2 1.4 0.936 2 1.4 1.752 2 1.9 1.871 2 3.4 1.928 2 0.5 2.059 2 0.9 1.1 2 2.4 83 5.64 0 3 442.57413 2.69 12.4 1325.70783

MEEVEAMLLPETLK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 6 1 50659080 M1(Oxidation); N-Term(iTRAQ4plex); M7(Oxidation); K14(iTRAQ4plex)

1.611 2 1.1 0.973 2 8.4 1.53 2 4.7 1.573 2 3.6 1.649 2 1.3 1.696 2 7 1.078 2 3.4 81 3.64 0 2 868.92987 -5.73 31.36 1736.856

MEEVEAMLLPETLKR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 9 1 50659080 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.533 4 10.1 1.115 4 17.7 1.423 4 10.3 1.313 4 13.4 1.768 4 12.2 1.581 4 5.8 1.251 4 13.2 76 8.18 0 3 886.47046 7.9 26.67 2657.39682

MEEVEAMLLPETLKR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 5 1 50659080 N-Term(iTRAQ4plex); M7(Oxidation); K14(iTRAQ4plex)

1.557 7 5.8 0.954 7 8.4 1.387 7 7.1 1.481 7 5.7 1.648 7 5.7 1.663 7 1.6 1.139 7 5.9 71 5.84 0 3 1094.9851 0.15 67.08 2188.95975

MENAELDVPIQSVFTR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 1 40317626 N-Term(iTRAQ4plex) 1.499 6 3 0.887 6 13.7 1.34 6 7.5 1.467 6 5.3 1.482 6 5.7 1.648 6 10.2 1.075 6 5.2 68 5.46 0 3 538.97931 3.1 51.95 1614.91924

MEPFHFK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 1 1 73858568 M1(Oxidation); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.376 2 4.3 0.845 2 6.1 1.208 2 4 1.43 2 2.1 1.329 2 6.5 1.573 2 12.7 1.1 2 10.5 65 5.13 0 3 1072.9863 1.17 31.17 2144.96538

MEPLNRTEVSEFFLK OR13J1 olfactory receptor 13J1 [Homo sapiens]

392309 NP_001004487 XP_373289

3 1 52218862 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.205 3 24.1 0.97 3 13.7 2.039 3 0.3 2.102 3 31.3 2.305 3 13.8 2.375 3 31.9 1.13 3 0.6 61 7.35 0 3 886.47046 7.9 26.67 2673.34842

MESLGITSR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 5 1 4557389 N-Term(iTRAQ4plex) 1.571 3 12.5 0.762 3 8.7 1.257 3 14.8 1.65 3 6.1 1.511 3 17.4 1.984 3 8.5 1.183 3 2.5 61 4.54 0 3 776.86945 -1.43 16.18 1552.73709

MESLGITSR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 2 1 4557389 M1(Oxidation); N-Term(iTRAQ4plex)

1.626 5 4.6 1.008 5 8.7 1.491 5 9 1.48 5 7.5 1.734 5 5.3 1.704 5 9.6 1.138 5 5.7 59 3.8 0 2 684.85345 -3.04 19.66 1368.69963

MFEELK CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 6 1 156627579 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.66 12 12.6 0.978 12 11.3 1.542 12 12.4 1.579 12 15.4 1.681 12 12.4 1.786 12 9.6 1.122 12 6.7 59 4.37 0 3 465.26569 1.23 40.01 1393.7825

MFIFAILPDGEVVGDSEK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.598 10 5.3 0.863 10 18 1.502 10 16.8 1.579 10 14.3 1.8 10 13.1 1.883 10 20.6 1.166 10 6.1 58 5.73 0 3 1125.978 2.68 74.17 2250.94187

MFPGVPLDTHDVFQYR MMP9 matrix metalloproteinase-9 preproprotein [Homo sapiens]

4318 NP_004985 2 1 74272287 N-Term(iTRAQ4plex) 1.792 2 4.7 0.864 2 8.7 1.596 2 7.9 1.847 2 0.8 1.746 2 9.6 2.02 2 0.9 1.094 2 1.7 57 7.92 1 3 782.36005 0.79 44.18 2345.06559

MFQNFPTELLLSLAVEPLTANFHK

GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 4 1 4503987 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.66 16 7.4 0.978 16 8.5 1.519 16 13.3 1.585 16 8.7 1.79 16 8.4 1.756 16 6.9 1.136 16 8.5 55 6.26 0 3 992.52435 1.35 33.31 1984.03745

MFQNFPTELLLSLAVEPLTANFHK

GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 2 1 4503987 M1(Oxidation); N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.32 4 1 1.035 4 13.8 1.345 4 12.1 1.283 4 11.8 1.455 4 10.8 1.456 4 11.2 1.125 4 1.3 54 2.8 0 2 571.32117 -15.69 19.32 1141.63506

MFTTAPDQVDK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 M1(Oxidation); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.611 10 2.3 1.122 10 5.8 1.613 10 8 1.426 10 3.9 1.831 10 5.3 1.648 10 3.7 1.142 10 5 48 3.91 0 2 738.35217 -2.03 26.89 1475.69695

MFTTAPDQVDK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.709 1 0.784 1 1.437 1 1.834 1 1.612 1 2.056 1 1.121 1 45 3.02 0 2 538.32135 0.39 11.2 1075.63542

MFTTAPDQVDKEDEDFQESNK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 77 1 4557485 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K21(iTRAQ4plex)

1.41 9 10.4 1.01 9 2.3 1.337 9 5.6 1.338 9 11.1 1.462 9 9.1 1.474 9 8.9 1.083 9 7.2 43 4.33 0 3 879.89581 -4.7 41.16 1758.79081

MFTTAPDQVDKEDEDFQESNK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 21 1 4557485 M1(Oxidation); N-Term(iTRAQ4plex); K11(iTRAQ4plex); K21(iTRAQ4plex)

1.519 7 11.3 0.982 7 5 1.481 7 15 1.513 7 18.7 1.587 7 14.1 1.563 7 12.4 1.041 7 5.9 42 6.67 0 3 881.42383 -9.16 19.11 2642.28238

MFVLTVAAENQVPLAK CDH2 cadherin-2 preproprotein [Homo sapiens]

1000 NP_001783 1 1 14589889 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.222 1 0.893 1 1.09 1 1.221 1 1.223 1 1.37 1 1.122 1 37 0 2 618.8833 3.13 17.46 1236.75932

MGDHLALEDYLTTDLVETWLR

SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 4 1 7705879 M1(Oxidation); N-Term(iTRAQ4plex)

1.562 1 0.937 1 1.376 1 1.468 1 1.651 1 1.761 1 1.199 1 23 0 2 470.21072 -0.33 11.57 939.41417

MGDHLALEDYLTTDLVETWLR

SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 22 1 7705879 N-Term(iTRAQ4plex) 1.278 1 1.291 1 1.54 1 1.193 1 1.387 1 1.075 1 0.901 1 7.33 0 4 1000.2282 4.32 48.64 3997.89101

MGIQHAYSENADFSGLTEDNGLK

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 8 1 205277441 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.555 8 7.3 0.887 8 17 1.406 8 16.2 1.593 8 3.3 1.592 8 16.5 1.818 8 3.6 1.139 8 3 3.19 0 2 631.31421 1.71 44.74 1261.62114

MGIQHAYSENADFSGLTEDNGLK

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 6 1 205277441 M1(Oxidation); N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.674 43 40.1 0.955 43 54.4 1.417 42 42.4 1.531 43 47.8 1.79 42 54.8 1.826 43 42.7 1.119 43 38.1 131 8.64 0 4 1026.5529 1.35 75.89 3077.64402

MGLAFESTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 13 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.115 7 12.3 0.921 7 14.2 1.963 7 20.3 2.144 7 13.3 2.006 7 15 2.395 7 10.9 1.022 7 7.9 122 7.69 0 3 1086.9884 2.7 29.6 2172.96384

MGLAFESTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 M1(Oxidation); N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.12 50 25.2 0.914 50 12.7 1.89 50 24.2 2.053 50 23.3 2.129 50 25 2.314 50 20.4 1.108 50 6.4 90 5.09 0 2 877.49463 -0.38 54.21 1753.98198

MGNFPWQVFTNIHGR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

7 1 66347875 M1(Oxidation); N-Term(iTRAQ4plex)

2.503 15 7.6 1.001 15 14.2 2.352 15 16.5 2.313 15 9.8 2.667 15 18.3 2.694 15 11.8 1.165 15 6.4 87 4.69 0 2 757.41473 -2.08 29.02 1513.82671

MGNFPWQVFTNIHGR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

6 1 66347875 N-Term(iTRAQ4plex) 5.06 10 12.4 1.004 3 40.9 2.387 10 9 2.086 3 20.7 2.802 10 11.5 3.014 3 15.7 1.141 10 7.8 78 7.21 0 3 1035.0099 -1.21 36.25 3103.01511

MGPTELLIEMEDWK FGB fibrinogen beta chain isoform 1 preproprotein [Homo sapiens]

2244 NP_005132 8 2 70906435 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.135 21 16.5 0.993 21 12 2.069 21 21 2.112 21 16.1 2.13 21 27.2 2.326 21 12.8 1.115 21 6.7 78 5.59 0 2 727.41278 -4.85 23.23 1453.81828

MGPTVSPICLPGTSSDYNLMDGDLGLISGWGR

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 8 1 41393602 N-Term(iTRAQ4plex); C9(Methylthio)

3.712 2 9.5 1.523 2 60.5 4.073 2 24.5 2.674 2 32.6 5.453 2 24.6 3.58 2 32.5 1.339 2 0.1 78 8.14 0 3 1133.5303 4.4 67.99 3398.57956

MGPTVSPICLPGTSSDYNLMDGDLGLISGWGR

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 8 1 41393602 M1(Oxidation); N-Term(iTRAQ4plex); C9(Methylthio)

2.22 8 17.1 1.05 8 19.3 2.252 8 12.5 2.244 8 14.6 2.398 8 13.1 2.291 8 19.2 1.056 8 4.9 73 5.82 0 2 906.45807 1.89 23.08 1811.89946

Page 29: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

MGSPGRGAGLYFSSSQGLGLIPSPGLSMWRLPR

ALDH7A1 alpha-aminoadipic semialdehyde dehydrogenase isoform 3 [Homo sapiens]

501 NP_001189333 1 1 320202964 N-Term(iTRAQ4plex); M28(Oxidation)

2.372 12 5 0.914 12 14.6 2.147 12 7.8 2.329 12 5.1 2.413 12 6.1 2.603 12 3.9 1.137 12 4.7 72 5.1 0 2 800.40906 -1.7 58.3 1599.81084

MGSSTSEK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 10 1 169636415 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.967 8 12.1 0.814 8 67.9 1.879 8 27.8 2.101 8 21.9 1.944 7 28.1 2.147 7 9.7 1.062 7 16.4 71 7.96 0 3 1133.5303 4.4 67.99 3382.58379

MGVEWTSCAEVVSQEK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 47 3 14550407 N-Term(iTRAQ4plex); C8(Methylthio); K16(iTRAQ4plex)

1.836 12 10.7 0.951 12 7.9 1.697 12 23.8 1.647 12 12.8 1.918 12 13.6 1.895 12 12.5 1.12 12 4.2 70 4.4 0 2 715.86444 -3.23 34.5 1430.72161

MHITLCDFIVPWDTLSTTQK TIMP2 metalloproteinase inhibitor 2 precursor [Homo sapiens]

7077 NP_003246 XP_946197

2 1 4507511 N-Term(iTRAQ4plex); C6(Methylthio); K20(iTRAQ4plex)

1.57 6 19.9 0.954 6 28.7 1.358 6 9 1.627 6 16.9 1.553 6 11.4 1.703 6 28.8 1.137 6 2 70 6.33 0 3 1016.3604 4.04 39.49 3047.05899

MHSMNGFMYGNQPGLTMCK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 6 1 4557485 N-Term(iTRAQ4plex); C18(Methylthio); K19(iTRAQ4plex)

2.363 9 5.4 1.011 9 13.6 2.072 9 18.4 2.115 9 13.6 2.495 9 14 2.506 9 16 1.168 9 2.4 62 5.73 0 3 622.35773 3.35 37.76 1865.05661

MHSMNGFMYGNQPGLTMCK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 4 1 4557485 N-Term(iTRAQ4plex); M17(Oxidation); C18(Methylthio); K19(iTRAQ4plex)

2.317 23 15.2 0.977 23 15.8 2.142 23 17.7 2.242 23 14.9 2.343 23 22.7 2.568 23 15.1 1.107 23 4 57 4.67 0 2 765.97809 -0.59 41.96 1530.9467

MINLSVPDTIDER LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 3 167614506 M1(Oxidation); N-Term(iTRAQ4plex)

1.39 7 8.1 1.088 7 14.6 1.362 7 22.3 1.253 7 5.5 1.539 7 24.3 1.415 7 11.6 1.097 7 2.5 56 3.45 0 2 655.77899 0.5 47.42 1310.54448

MINLSVPDTIDER LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 3 167614506 N-Term(iTRAQ4plex) 2.22 7 28.6 1.025 7 5.6 1.823 7 41.2 2.108 7 32.6 1.947 7 39.7 2.412 7 21.9 1.136 7 2.2 55 3.68 0 2 623.81348 0.99 17.33 1246.61968MKPVPDLVPGNFK FGA fibrinogen alpha chain isoform alpha-

E preproprotein [Homo sapiens]2243 NP_000499 1 2 4503689 N-Term(iTRAQ4plex);

K2(iTRAQ4plex); K13(iTRAQ4plex)

2.463 4 5.9 1.054 4 11.9 2.329 4 14.9 2.257 4 2 2.728 4 11.7 2.589 4 2.3 1.171 4 5.3 55 2.95 0 2 605.85406 7.17 16.29 1210.70024

MLADAPPQDPSCCSGALYYGSK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 16 1 70778918 M1(Oxidation); N-Term(iTRAQ4plex); C12(Methylthio); C13(Methylthio); K22(iTRAQ4plex)

1.385 1 0.956 1 1.262 1 1.319 1 1.447 1 1.513 1 1.147 1 54 4.58 0 2 916.50183 -4.41 36.66 1831.99639

MLADAPPQDPSCCSGALYYGSK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 99 1 70778918 N-Term(iTRAQ4plex); C12(Methylthio); C13(Methylthio); K22(iTRAQ4plex)

2.505 5 1.2 1.036 5 9.1 2.37 5 11.5 2.326 5 2.4 2.711 5 0.9 2.635 5 6.9 1.11 5 5.4 52 3.48 0 3 613.33777 1.28 14.24 1225.66761

MLEVPYVDR F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 8 1 4503625 N-Term(iTRAQ4plex) 2.354 6 8.3 0.897 6 11.7 2.014 6 13.3 2.22 6 9.7 2.383 6 18.8 2.587 6 7.1 1.145 6 5.2 47 3.83 0 2 588.32275 -0.56 30.41 1175.63799

MLEVPYVDR F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 2 1 4503625 M1(Oxidation); N-Term(iTRAQ4plex)

1.75 1 1.035 1 1.705 1 1.647 1 1.857 1 1.794 1 1.089 1 43 5.16 1 3 506.58713 0.21 15.42 1517.74683

MLFDK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 1 2 73858566 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

2.3 7 19.3 1.047 7 7.8 2.247 7 33.4 2.177 7 9.3 2.492 7 26.9 2.467 7 7.9 1.109 7 1.3 43 0 2 529.81366 7.16 20.19 1058.61553

MLLDQYR MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 1 1 51477714 N-Term(iTRAQ4plex) 2.155 2 2.3 1.198 2 9.4 2.204 2 8.2 1.839 2 1.2 2.534 2 1.8 2.114 2 11.2 1.15 2 10 39 1 3 444.27435 -0.75 17.12 1330.80851

MLPTQAGAAAALGRGSALGGSLNR

SRF serum response factor [Homo sapiens]

6722 NP_003122 1 1 4507205 M1(Oxidation); N-Term(iTRAQ4plex)

1.968 6 19.5 0.925 6 9.6 1.756 6 17.2 1.909 6 20.5 2.024 6 13.4 2.177 6 11.4 1.131 6 6.5 36 3 0 2 513.72723 0.65 28.05 1026.44719

MLQGLLPVSLLLSVAVSAIK ADAM28 disintegrin and metalloproteinase domain-containing protein 28 isoform 3 preproprotein [Homo sapiens]

10863 NP_068547 1 2 54292117 M1(Oxidation); N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.942 2 3.6 0.896 2 4 1.719 2 1.7 1.92 2 5.8 1.962 2 1.7 2.191 2 5.7 1.141 2 0 34 3.35 1 2 591.77802 0.94 12.26 1182.54875

MLSPGFDSSVYSDLCEAAEAVRPEER

ADAMTSL2 ADAMTS-like protein 2 precursor [Homo sapiens]

9719 NP_055509 XP_003403622 XP_003403874 XP 003403875

4 1 41281450 N-Term(iTRAQ4plex); C15(Methylthio)

2.127 1 0.806 1 1.757 1 2.181 1 2.083 1 2.585 1 1.185 1 2.78 0 2 503.31223 -1.11 13.91 1005.61717

MLSSFLSEDVFK ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 2 1 157266300 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.643 1 1.027 1 1.539 1 1.499 1 1.791 1 1.744 1 1.164 1 66 8.2 0 3 825.43347 -0.27 46.09 2474.28586

MLTPEHVFIHPGWK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 9 1 41393602 M1(Oxidation); N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.183 1 1.047 1 2.095 1 2.002 1 2.372 1 2.266 1 1.132 1 52 4.54 0 2 675.31842 -0.45 22.04 1349.62956

MLTPEHVFIHPGWK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 17 1 41393602 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.478 1 0.784 1 2.066 1 2.634 1 2.356 1 3.003 1 1.14 1 45 6.94 0 3 886.78802 -3.34 18.01 2658.34952

MMAVAADTLQR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 6 1 21071039 N-Term(iTRAQ4plex) 2.037 1 1.024 1 2.018 1 1.971 1 2.105 1 2.055 1 1.043 1 38 5.64 0 3 829.74438 -8.16 20.76 2487.2186

MNTVIAALSR SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 19 1 73858564 N-Term(iTRAQ4plex) 2.643 2 1 0.933 2 13 2.434 2 5.5 2.608 2 7.5 2.68 2 5.2 2.872 2 7.8 1.101 2 0.3 31 0 2 429.79788 -0.99 29.16 858.58849

MNTVIAALSR SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 2 1 73858564 M1(Oxidation); N-Term(iTRAQ4plex)

1.407 6 13.1 0.786 6 31.9 1.206 6 28.1 1.439 6 5.6 1.343 6 30.2 1.683 6 1.7 1.138 6 11 92 8.31 0 3 681.06207 1.55 50.47 2041.16782

MNVAPACLPER F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 6 1 4503625 N-Term(iTRAQ4plex); C7(Methylthio)

1.303 2 10.9 1.45 2 38.8 1.432 2 33.1 0.988 2 5.2 1.784 2 34.6 1.231 2 3.8 1.246 2 1.3 89 6.57 0 3 1423.7819 0.19 69.49 4269.33103

MNVAPACLPER F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 2 1 4503625 M1(Oxidation); N-Term(iTRAQ4plex); C7(Methylthio)

1.298 5 2.8 1.068 5 7.9 1.21 5 10.5 1.192 5 7.6 1.422 5 14.6 1.432 5 9.7 1.143 5 2.3 74 3.62 0 2 660.84766 -0.4 9.24 1320.68804

MPITYDNGFLFIHTDKPVYTPDQSVK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 14 2 38016947 N-Term(iTRAQ4plex); K16(iTRAQ4plex); K26(iTRAQ4plex)

1.227 10 6.8 1 10 17.9 1.096 10 9.1 1.161 10 18.7 1.357 10 8 1.32 10 12.4 1.153 10 13.1 72 5.44 0 2 1041.525 0.25 55.75 2082.04277

MPITYDNGFLFIHTDKPVYTPDQSVK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 M1(Oxidation); N-Term(iTRAQ4plex); K16(iTRAQ4plex); K26(iTRAQ4plex)

1.396 4 10.6 0.871 4 6 1.174 4 6 1.412 4 12.4 1.384 4 7.8 1.665 4 17.2 1.168 4 5.3 72 8.04 0 3 1437.2686 7.71 31.57 2873.52793

MPMGLSTGIISDSQIK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.302 7 10.3 0.971 7 17.5 1.135 7 13.6 1.191 7 12.2 1.316 7 20.6 1.346 7 8.3 1.148 7 5.7 71 4.98 0 2 781.39282 7.77 16.08 1561.75163

MPYECGPSLDVCAQDER C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 8 1 45580688 M1(Oxidation); N-Term(iTRAQ4plex); C5(Methylthio); C12(Methylthio)

1.398 7 10.2 0.972 7 13.3 1.212 7 15.8 1.333 7 4.8 1.542 7 8.3 1.58 7 19.4 1.186 7 18.7 56 9.13 0 5 1118.2706 7.69 35.9 3352.7754

MPYECGPSLDVCAQDER C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 2 1 45580688 N-Term(iTRAQ4plex); C5(Methylthio); C12(Methylthio)

1.275 6 3.1 0.992 6 6 1.219 6 5.5 1.172 6 11.3 1.333 6 2.6 1.344 6 7.5 1.107 6 8.7 49 5.52 0 3 1017.0432 9.62 21.1 2033.04306

MQCDR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 1 1 110611237 N-Term(iTRAQ4plex); C3(Methylthio)

1.148 2 3.3 0.903 2 0.1 1.043 2 2.7 1.156 2 2.8 1.141 2 3.7 1.264 2 3.9 1.093 2 1.1 49 4.84 0 3 781.39282 7.77 16.08 1577.76322

MQILEGLGLNLQK SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 4 1 194018472 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.327 4 10.9 0.723 4 15.2 0.844 4 22.1 1.262 4 34.2 1.393 4 17.1 1.951 4 3.4 1.511 4 35.9 48 10.85 0 5 985.22021 1.45 54.66 3937.8465

MREWFSETFQK APOC1 apolipoprotein C-I precursor [Homo sapiens]

341 NP_001636 2 1 4502157 M1(Oxidation); N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.126 3 8.7 0.982 3 4.9 1.024 3 19.3 1.086 3 6 1.208 3 14.7 1.258 3 3.2 1.158 3 2.7 45 3.99 0 2 653.8219 0.05 31.92 1306.63652

MRPSTDTITVMVENSHGLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

31 6 178557739;67190748

M1(Oxidation); N-Term(iTRAQ4plex)

1.384 2 11.1 0.868 2 17.6 1.275 2 21.3 1.468 2 3.5 1.315 2 17.5 1.514 2 0.1 1.031 2 3.7 44 2.78 0 2 545.28632 -0.32 18.71 1089.56536

MRPSTDTITVMVENSHGLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

108 6 178557739;67190748

N-Term(iTRAQ4plex) 1.173 4 7.2 0.904 4 12.4 1.081 4 8.6 1.206 4 10.2 1.22 4 7.6 1.388 4 11.3 1.136 4 2 43 3.21 0 2 563.83868 -0.02 31.85 1126.67009

MRPSTDTITVMVENSHGLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

M1(Oxidation); N-Term(iTRAQ4plex); M11(Oxidation)

1.274 4 5.9 1.05 4 5.5 1.241 4 12.4 1.184 4 0.8 1.376 4 12.5 1.314 4 0.9 1.111 4 0.3 41 3.43 0 2 615.37109 1.19 44.49 1229.73235

MSAQTHGLLGQFFQPFDFK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 2 1 133925809 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.289 1 0.863 1 1.113 1 1.29 1 1.289 1 1.492 1 1.157 1 32 0 2 644.83624 -0.18 32.19 1288.66521

MSAVEGICTSESPVIDHQGTK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 28 2 38016947 N-Term(iTRAQ4plex); C8(Methylthio); K21(iTRAQ4plex)

1.546 1 1.175 1 1.668 1 1.419 1 1.696 1 1.443 1 1.017 1 30 8.9 0 4 985.22021 1.45 54.66 3953.85122

MSAVEGICTSESPVIDHQGTK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 M1(Oxidation); N-Term(iTRAQ4plex); C8(Methylthio); K21(iTRAQ4plex)

1.259 1 0.93 1 1.235 1 1.327 1 1.196 1 1.286 1 0.969 1 3.52 0 3 1038.8812 0.9 57.44 3114.62912

MSENIPNEVYALGAFDGLHTVEGR

VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 10 1 223633991 N-Term(iTRAQ4plex) 0.144 1 0.909 1 0.124 1 0.137 1 0.151 1 0.166 1 1.21 1 100 5.25 0 2 918.95697 -1.63 39.79 1836.90666

MSESGFK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

M1(Oxidation); N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.831 4 10.2 0.907 4 22.9 0.742 4 12.2 0.888 4 15.3 0.876 4 5 0.985 4 12.4 1.11 4 8.3 98 5.92 0 2 894.94995 0.39 36.03 1788.89263

MSESGFK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

3 5 47132549;16933542

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.842 3 5.7 0.898 3 21.9 1.493 3 18.4 1.88 3 5 1.763 3 14.6 2.167 3 8.8 1.152 3 3.7 80 5.59 0 3 894.94995 0.39 36.03 1804.89328

MSGECAPNVSVSVSTSHTTISGGGSR

KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 4 2 119395750 N-Term(iTRAQ4plex); C5(Methylthio)

1.228 7 11.2 1.031 7 16.2 1.21 7 16.6 1.199 7 8.2 1.385 7 12.1 1.353 7 7.6 1.132 7 9.5 79 5.01 0 2 757.91119 3.8 30.23 1514.81023

MSGECAPNVSVSVSTSHTTISGGGSR

KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 2 2 119395750 M1(Oxidation); N-Term(iTRAQ4plex); C5(Methylthio)

1.023 4 8.3 1.022 4 5.5 1.02 4 5 0.973 4 6.7 1.074 4 10.1 1.112 4 4.6 1.125 4 5.2 47 7.28 0 4 780.04901 0.57 24.72 2338.13271

MSNMGSPPPPQPPPPDLSTELYYCK

ZNF462 zinc finger protein 462 [Homo sapiens]

58499 NP_067047 5 1 114431236 N-Term(iTRAQ4plex); C24(Methylthio); K25(iTRAQ4plex)

1.754 3 3.2 1.05 3 8.4 1.661 3 0.3 1.628 3 13 1.885 3 6.1 1.795 3 2.2 1.102 3 4.4 42 4.68 1 3 654.32996 -6.45 20.74 1960.97531

MSSINADFAFNLYR SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 60 1 205277441 N-Term(iTRAQ4plex) 0.075 1 0.962 1 0.058 1 0.06 1 0.089 1 0.093 1 1.536 1 63 4.95 0 2 1052.497 10.9 67.84 2103.98662

MSSINADFAFNLYR SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 3 1 205277441 M1(Oxidation); N-Term(iTRAQ4plex)

0.84 1 1.046 1 0.787 1 0.753 1 0.932 1 0.891 1 1.184 1 56 5.56 0 3 740.0481 1.61 55.74 2218.12973

MTLDDFR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 M1(Oxidation); N-Term(iTRAQ4plex)

1.186 2 4.4 1.036 2 4.6 1.135 2 7.6 1.096 2 3 1.28 2 6 1.236 2 1.4 1.128 2 1.6 63 4.71 0 2 765.40497 -1.53 14.93 1529.80266

MTLDDFR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex) 0.908 1 1.12 1 0.901 1 0.804 1 1.025 1 0.915 1 1.138 1 68 7.12 0 3 754.4248 1.56 60.63 2261.25986

MTMDK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

2 3 31542984;262050538

N-Term(iTRAQ4plex); K5(iTRAQ4plex)

0.979 1 0.978 1 0.805 1 0.824 1 1.131 1 1.157 1 1.405 1 54 4.72 0 3 647.62634 -5.52 32.88 1940.86448

MTSNFPVDLSDYPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 17 1 105990532 M1(Oxidation); N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.265 5 12.6 1.023 5 20.9 1.133 5 12.2 1.203 5 18.2 1.489 5 3.7 1.456 5 24.7 1.145 5 8.9 96 7.23 0 3 1192.6083 -3.85 31.76 2384.20658

MTSNFPVDLSDYPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.235 3 3.7 1.015 3 7.2 1.227 3 2.2 1.157 3 15.9 1.364 3 5.4 1.295 3 12.6 1.119 3 3.2 82 4.67 0 2 1025.9822 4.24 68.62 2050.95757

MTTDEGTGGR PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 1 1 157653329 N-Term(iTRAQ4plex) 1.31 1 0.707 1 1.017 1 1.439 1 1.219 1 1.725 1 1.199 1 79 7.51 0 3 616.26898 -0.29 13.67 1846.79239

MTVSTLVLGEGATEAEISMTSTR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 5 1 4502067 N-Term(iTRAQ4plex); M19(Oxidation)

1.272 6 5.9 1.054 6 10.8 1.247 6 9.3 1.183 6 2.9 1.394 6 10.8 1.33 6 5.4 1.125 6 1.8 73 5.05 0 2 799.40814 -2.79 25.37 1597.80901

MTVSTLVLGEGATEAEISMTSTR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 4 1 4502067 N-Term(iTRAQ4plex) 1.946 5 19.8 0.99 5 12.9 1.825 5 27.6 1.844 5 14.4 2.047 5 23.2 2.068 5 8.5 1.121 5 5.9 72 3.7 0 2 799.40814 -2.79 25.37 1613.80657

MTVSTLVLGEGATEAEISMTSTRWR

AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 3 1 4502067 M1(Oxidation); N-Term(iTRAQ4plex)

1.309 3 6.1 0.754 3 8.9 1.303 3 3.3 1.741 3 2.2 1.329 3 14.9 1.315 3 3.6 1.02 3 11.6 69 4.66 0 3 995.40613 1.82 16.15 1989.80948

MTVTDQVNCPK APOD apolipoprotein D precursor [Homo sapiens]

347 NP_001638 2 1 4502163 N-Term(iTRAQ4plex); C9(Methylthio); K11(iTRAQ4plex)

1.221 9 7.9 0.868 9 7.5 1.188 9 22.7 1.192 9 4.2 1.35 9 16.7 1.383 9 6.9 1.149 9 1.9 59 3.74 0 2 793.88483 11.46 33.48 1586.76238

MVCGPSGSQLVLLK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 7 1 205277383 N-Term(iTRAQ4plex); C3(Methylthio); K14(iTRAQ4plex)

1.344 2 4.1 0.901 2 16.1 1.178 2 12.3 1.308 2 3.8 1.38 2 11.2 1.531 2 4.8 1.171 2 1.1 58 4.91 0 3 495.9281 -0.59 49.33 1485.773

MVETTAYALLTSLNLK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 14 2 38016947 M1(Oxidation); N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.134 2 10.3 1.118 2 11.3 1.254 2 19.1 1.122 2 7.7 1.149 2 13.4 1.028 2 2.1 0.916 2 5.6 56 6.52 1 3 809.02423 -1.47 16.73 2425.05814

MVETTAYALLTSLNLK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 30 2 38016947 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.125 3 3.8 1.004 3 3.6 1.042 3 1.4 1.053 3 2.2 1.213 3 9.3 1.208 3 2.5 1.132 3 3.7 52 3.96 0 2 695.84082 -1.35 40.79 1390.67436

MVLLEQLFLDHNALR GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 14 1 4758460 N-Term(iTRAQ4plex) 1.113 2 1.3 1.014 2 4.2 1.064 2 1.8 1.049 2 2.4 1.177 2 0.2 1.161 2 4.4 1.106 2 2 50 2.82 0 2 584.3139 8.63 17.21 1167.62053

MVQEQCCHSQLEELHCATGISLANEQDR

FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

4 4 34734066;34734062

N-Term(iTRAQ4plex); C6(Methylthio); C7(Methylthio); C16(Methylthio)

1.277 2 12.6 0.977 2 7.4 1.177 2 19.9 1.206 2 12.4 1.347 2 13.1 1.379 2 5.7 1.144 2 6.7 46 3.58 0 2 519.29584 -1.6 32.55 1037.5844

MVQQECK AFM afamin precursor [Homo sapiens] 173 NP_001124 6 1 4501987 M1(Oxidation); N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

1.946 1 0.827 1 1.708 1 2.064 1 1.847 1 2.233 1 1.082 1 45 3.46 0 2 695.84082 -1.35 40.79 1406.66924

MVQQECK AFM afamin precursor [Homo sapiens] 173 NP_001124 2 1 4501987 N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

1.132 1 1.204 1 1.191 1 0.989 1 1.304 1 1.083 1 1.095 1 39 0 2 483.81573 1.6 20.72 966.62419

MVSGFIPLKPTVK A2M;PZP alpha-2-macroglobulin precursor [Homo sapiens];pregnancy zone protein precursor [Homo sapiens]

2;5858 NP_000005;NP_002855

4 2 66932947;162809334

N-Term(iTRAQ4plex); K9(iTRAQ4plex); K13(iTRAQ4plex)

1.112 5 10 1.004 5 8 1.095 5 7.9 1.083 5 1 1.134 5 14.7 1.171 5 5.4 1.123 5 1.9 39 3.06 0 2 633.33807 0.63 44.34 1265.66655

MVVSMTLGLHPWIANIDDTQYLAAK

CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 5 1 21071039 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.925 2 12.7 0.953 2 0.6 1.772 2 10.2 1.859 2 10.8 1.986 2 14.3 2.084 2 14.9 1.121 2 4.1 2.93 0 2 633.33807 0.63 44.34 1281.65959

MYEQEWVR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 1 1 105990535 N-Term(iTRAQ4plex) 1.452 1 0.838 1 1.191 1 1.421 1 1.478 1 1.764 1 1.241 1 94 8.25 0 3 819.75891 3.3 43.77 2457.26218

MYEVVYQIGTETR PCYOX1 prenylcysteine oxidase 1 precursor [Homo sapiens]

51449 NP_057381 2 1 166795301 N-Term(iTRAQ4plex) 1.074 1 0.895 1 0.969 1 1.083 1 1.065 1 1.19 1 1.099 1 76 3.18 0 2 804.42188 -0.68 26.66 1607.83647

MYFDAVQAIETHLIR MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 8 1 24497519 N-Term(iTRAQ4plex) 1.19 2 39.8 1.105 2 14.2 1.055 2 48 0.955 2 65.4 1.444 2 20.4 1.307 2 35.3 1.368 2 25.8 73 4.76 0 2 799.93677 -2.5 33.07 1598.86626

MYFDAVQAIETHLIR MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 4 1 24497519 M1(Oxidation); N-Term(iTRAQ4plex)

0.934 4 50.6 0.971 4 7 0.861 4 59.8 0.896 4 51.3 0.979 4 49 0.981 4 42.4 1.104 4 6.2 67 3.37 0 2 666.87329 -0.67 18.07 1332.73931

MYGCDLGPDGR HLA-C HLA class I histocompatibility antigen, Cw-1 alpha chain precursor [Homo sapiens]

3107 NP_001229971 XP_003119292-XP_003119305 XP_003119407-XP 003119421

2 1 339882741 N-Term(iTRAQ4plex); C4(Methylthio)

1.617 2 12.7 0.725 2 50.8 1.314 2 40.9 1.813 2 8.6 1.509 2 27.7 2.082 2 20.9 1.149 2 12.2 67 3.64 0 2 1112.0342 2.62 56.04 2223.06108

MYQMDIQQELQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 M1(Oxidation); N-Term(iTRAQ4plex)

1.5 2 2.8 0.867 2 15.4 1.336 2 2.7 1.541 2 12.7 1.468 2 5.8 1.693 2 9.6 1.099 2 3.1 66 7.17 0 3 723.37262 1.26 34.6 2168.09891

MYQMDIQQELQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 15 1 105990532 M1(Oxidation); N-Term(iTRAQ4plex); M4(Oxidation)

1.811 2 6.1 0.901 2 14 1.662 2 4.4 1.846 2 18.4 1.782 2 5.1 1.978 2 8.8 1.072 2 9.5 60 3.27 0 2 589.81012 -0.36 25.7 1178.61431

MYSVNGYTFGSLPGLSMCAEDR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 10 1 4557485 N-Term(iTRAQ4plex); C18(Methylthio)

1.272 1 0.87 1 1.108 1 1.273 1 1.271 1 1.461 1 1.148 1 57 3.98 0 2 700.36945 -4.68 29.81 1399.73161

MYSVNGYTFGSLPGLSMCAEDR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 3 1 4557485 N-Term(iTRAQ4plex); M17(Oxidation); C18(Methylthio)

1.599 3 8.8 0.918 3 15.3 1.4 3 7.2 1.617 3 8.7 1.584 3 3.2 1.831 3 7.2 1.107 3 5.4 54 3.33 0 2 502.30502 1.06 23.29 1003.60277

MYVAVWTPYGVLR F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 2 1 119395709 N-Term(iTRAQ4plex) 1.396 1 0.96 1 1.283 1 1.337 1 1.454 1 1.515 1 1.133 1 53 4.98 0 2 679.83868 1.72 48.81 1358.67009

MYYSAVDPTK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 9 1 4557485 M1(Oxidation); N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.426 3 22 0.905 3 34.5 1.275 3 45.4 1.409 3 1.7 1.441 3 38.7 1.639 3 4.2 1.131 3 1.8 53 3.18 0 2 615.8338 -1.16 45.85 1230.66033

MYYSAVDPTK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 83 1 4557485 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.527 2 4 0.785 2 17.6 1.307 2 14.7 1.666 2 2.9 1.422 2 9 1.812 2 8.6 1.088 2 5.7 49 3.61 0 2 581.31476 -0.85 26.5 1161.62187

MYYSAVDPTKDIFTGLIGPMK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 10 1 4557485 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K21(iTRAQ4plex)

1.371 2 10.5 0.955 2 8.2 1.259 2 16.8 1.318 2 8.4 1.422 2 12.5 1.488 2 4.3 1.129 2 4.2 49 4.86 0 2 693.82788 0.14 53.99 1386.64849

MYYSAVDPTKDIFTGLIGPMK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 4 1 4557485 M1(Oxidation); N-Term(iTRAQ4plex); K10(iTRAQ4plex); K21(iTRAQ4plex)

1.499 1 0.802 1 1.391 1 1.733 1 1.312 1 1.635 1 0.943 1 48 5.96 0 4 513.70905 -10.21 31.02 2051.81435

NAAENGAIQNLIK MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 2 1 4557739 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.557 1 0.926 1 1.418 1 1.53 1 1.582 1 1.708 1 1.116 1 48 3.87 0 2 534.30225 0.57 31.63 1067.59722

NADYSYSVWK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 38 2 38016947 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.191 1 0.89 1 2.018 1 2.269 1 2.122 1 2.386 1 1.052 1 44 6.27 0 3 866.46722 0.65 72.89 2597.38712

NAEELK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 1 1 71773110 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.64 1 0.945 1 1.619 1 1.713 1 1.57 1 1.662 1 0.97 1 39 4.5 0 3 997.79779 -0.68 65.55 2991.37882

NAIGGKFPLYNLGFGNNLNYNFLENMALENHGFAR

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 12 1 133925809 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.485 1 0.813 1 1.242 1 1.528 1 1.45 1 1.784 1 1.168 1 28 0 2 570.74829 -0.12 9.87 1140.48931

NAIWIDCGIHAR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 12 2 126273569 N-Term(iTRAQ4plex); C7(Methylthio)

1.801 1 1.061 1 1.706 1 1.608 1 2.006 1 1.892 1 1.176 1 3.73 0 3 833.76337 -2.83 33.58 2499.27555

NALALFVLPK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 17 1 205277441 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.223 54 8 0.987 54 9.9 1.12 54 11.7 1.153 54 9.5 1.289 54 12 1.324 54 6.4 1.152 54 10.3 119 7 0 3 1048.9945 2.59 61.82 2096.97708

NALFCLESAWK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 21 1 66932947 N-Term(iTRAQ4plex); C5(Methylthio); K11(iTRAQ4plex)

1.178 95 17 0.979 95 12.4 1.117 95 26.1 1.094 95 15.5 1.213 95 16.1 1.243 95 15.8 1.119 95 9.6 115 7.07 0 3 1045.9653 -0.72 73.28 2090.92339

NALFCLESAWNVAK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 10 1 162809334 N-Term(iTRAQ4plex); C5(Methylthio); K14(iTRAQ4plex)

1.204 21 27.7 0.91 20 14 1.034 20 16.1 1.151 19 21.8 1.173 21 26.6 1.304 20 25 1.144 20 11.7 114 8.75 1 3 852.06512 -0.7 40.94 2554.18137

NALQNIILYHLTPGVFIGK POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 2 4 209863034 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.202 75 12 0.949 75 18.6 1.059 75 23.8 1.122 75 16.1 1.212 75 21.9 1.284 75 15.5 1.137 75 14.8 102 8.01 0 3 1136.6116 -1.17 47.42 2272.23374

NALTGLPPGLFQASATLDTLVLK

LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 49 1 16418467 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.238 18 10.2 0.963 18 14.2 1.103 18 17.8 1.181 18 9.9 1.267 18 10.7 1.337 18 8 1.151 18 6.3 101 6.17 0 2 770.43018 -5.87 24.13 1539.85527

NANFK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 3 2 4826762 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

2.913 1 1.023 1 2.837 1 2.774 1 3.056 1 2.987 1 1.077 1 99 3.74 0 2 1221.1023 0.43 44.88 2441.19731

NAVPPVIHSPNDHVVYEK IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 1 3 19882209 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.235 17 6.4 0.968 17 19.9 1.135 17 15.3 1.149 17 9.6 1.305 17 10.1 1.31 17 12 1.162 17 10.6 99 6.74 0 2 1102.5336 6.98 34.41 2204.05986

NCELDVTCNIK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 2 1 4503649 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); K11(iTRAQ4plex)

1.278 21 5.2 0.945 21 11 1.176 21 11.4 1.245 21 6.6 1.327 21 10.8 1.42 21 7.2 1.131 21 4.9 94 6.76 0 2 1081.0396 2.65 39.99 2161.07768

NCIDITGVR LMAN2 vesicular integral-membrane protein VIP36 precursor [Homo sapiens]

10960 NP_006807 1 1 5803023 N-Term(iTRAQ4plex); C2(Methylthio)

1.138 19 7 0.946 19 17.9 1.067 19 9.6 1.055 19 9.1 1.194 19 9.5 1.214 19 8.3 1.147 19 8 91 5.91 0 2 1144.5117 3.54 28.47 2288.01616

NDFTWFK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 94 1 62739186 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.059 16 11.2 1.048 16 14.7 1.037 16 20.3 0.964 16 20.3 1.177 16 16.2 1.069 16 18.5 1.121 16 3.7 91 6.4 0 2 902.39862 -3.06 25.43 1803.78996

NDLISATK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 11 1 70778918 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

2.051 4 7.6 1.057 4 0.7 2.125 4 5.6 2.011 4 5.5 2.07 4 16.6 1.984 4 11.2 1.089 4 7 90 5.1 0 3 1142.0371 -6.62 24.33 2283.09208

NDLSPTTVMSEGAR BLVRB flavin reductase (NADPH) [Homo sapiens]

645 NP_000704 2 1 4502419 N-Term(iTRAQ4plex) 1.161 27 7.4 0.977 26 6.9 1.055 27 10.2 1.111 26 9.3 1.199 27 14.2 1.253 26 6.6 1.125 27 7.1 89 5.95 0 3 889.95038 2.07 55.1 1778.89348

NDYLDIYAIGVGK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 2 3 14550407 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.098 10 12.2 1.017 10 10.3 1.024 10 19.4 1.017 10 12.9 1.234 10 26.6 1.242 10 24.3 1.157 10 6.8 88 7.75 0 3 1221.1023 0.43 44.88 2409.21109

NEALIALLR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 1 167614506 N-Term(iTRAQ4plex) 1.571 7 10.3 1.062 7 10.4 1.487 7 8.1 1.548 7 15 1.713 7 20.5 1.665 7 17.1 1.095 7 7.5 86 5.5 0 3 902.39862 -3.06 25.43 1819.78305NEDSLVFVQTDK A2M alpha-2-macroglobulin precursor

[Homo sapiens]2 NP_000005 9 1 66932947 N-Term(iTRAQ4plex);

K12(iTRAQ4plex)1.502 9 3.4 0.936 9 19.7 1.404 9 14.7 1.444 9 5.9 1.475 9 10.9 1.531 9 10.8 1.111 9 4.4 84 6 1 2 1026.0499 2.8 37.25 2051.09258

NEEALDTESSER NEO1 neogenin isoform 2 precursor [Homo sapiens]

4756 NP_001166094 2 3 290656011 N-Term(iTRAQ4plex) 1.191 40 11.2 0.946 40 11.5 1.087 40 15.7 1.166 40 12.4 1.209 40 15.7 1.291 40 14.6 1.108 40 8.1 83 8.38 0 3 1255.2185 2.37 49.2 2509.42838

Page 30: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

NELESYAYSLK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 2 1 16507237 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.755 5 19.1 0.88 5 10.5 1.578 5 11.9 1.605 5 16.5 1.721 5 23.2 1.942 5 31.1 1.091 5 9 83 7.53 0 3 1221.1023 0.43 44.88 2425.20462

NELIPLIYLENPR PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex) 1.128 7 29.3 1 7 26.2 1.01 7 51.4 1.062 7 2.9 1.194 7 46.4 1.288 7 5.3 1.182 7 6.2 81 6.71 0 3 1142.0371 -6.62 24.33 2267.08774

NEQVEIR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex) 0.88 3 0.8 0.923 3 1.2 0.84 3 4.1 0.871 3 10.8 0.969 3 4.3 0.961 3 7 1.122 3 2.4 79 7.69 1 3 1239.5847 5.36 44.46 2478.14994

NEVWWTIDGK IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 4 3 19882209 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.225 11 2.7 0.966 11 8.2 1.174 11 15.2 1.158 11 7.1 1.286 11 9.5 1.357 11 6.5 1.095 11 14.9 78 6.71 0 3 1146.1118 10.65 34.67 2291.19229

NFATSNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.93 8 17.3 0.932 8 14.8 0.855 8 17.1 0.897 8 8 0.961 8 14.1 1.077 8 12.6 1.145 8 7 77 5.93 0 2 853.41931 0.64 44.63 1705.83135

NFEDVAFDEK P4HB protein disulfide-isomerase precursor [Homo sapiens]

5034 NP_000909 2 1 20070125 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.063 37 5.6 0.973 37 9 0.98 37 7.6 1.008 37 5.7 1.118 37 9.3 1.146 37 6.1 1.137 37 5.4 74 5.25 0 3 988.93378 1.43 52.76 1976.8676

NFEITIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 11 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.011 2 0.7 0.886 2 7.4 0.901 2 0.9 1.016 2 6.5 1.006 2 7.1 1.135 2 0.4 1.117 2 6.1 74 4.71 0 2 1199.5509 5.44 41.79 2398.09453

NFGDLVSIQSESEK LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 2 2 341915493 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.415 8 44.9 0.988 8 8.3 1.652 9 15.6 1.284 8 71.8 1.31 8 74.8 1.218 8 83 1.16 9 13.9 74 8.66 1 3 852.06512 -0.7 40.94 2570.16867

NFGYTLR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 1 1 73858566 N-Term(iTRAQ4plex) 1.677 16 8.9 0.985 16 4.5 1.526 16 12.9 1.562 16 7.8 1.773 16 8.8 1.818 16 6.5 1.153 16 4.5 71 4.76 0 3 988.93378 1.43 52.76 1992.85246

NFPDLNTYIYYNEK CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 18 1 4503011 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.184 5 14.1 1.029 5 22.1 1.09 5 6.2 1.148 5 7.4 1.237 5 8.1 1.302 5 11.9 1.127 5 1 66 3.95 0 2 647.36029 7.07 17.8 1293.69988

NFPSPVDAAFR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 392 1 11321561 N-Term(iTRAQ4plex) 1.212 1 1.157 1 1.192 1 1.03 1 1.421 1 1.229 1 1.192 1 63 6.29 1 3 653.96698 -5.22 19.49 1959.88639

NFVASHIANILNSEELDIQDLK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 34 1 105990532 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.791 3 2.1 1.173 3 6.1 1.673 3 7.3 1.498 3 13.5 1.909 3 3.8 1.868 3 11.2 1.208 3 4.7 63 5.04 1 4 1220.1039 7.1 20.65 2439.20156

NFVASHIANILNSEELDIQDLKK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex); K22(iTRAQ4plex); K23(iTRAQ4plex)

1.041 3 4.4 1.046 3 8.4 0.95 3 0.1 0.968 3 9.6 1.119 3 0.7 1.134 3 0.7 1.172 3 0.8 58 5.52 1 4 1220.1039 7.1 20.65 2423.21059

NGIDIYSLTVDSR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

12 2 31542984;262050538

N-Term(iTRAQ4plex) 1.094 18 6.8 0.931 18 6.4 1.018 18 7.4 1.065 18 7.1 1.122 18 5.1 1.223 18 5.5 1.152 18 6.5 54 4.05 0 2 669.85516 0.63 30.05 1338.70305

NGLEENFCR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); C8(Methylthio)

1.295 14 11 1.025 14 19.3 1.276 14 15.3 1.221 14 11.6 1.44 14 14.9 1.34 14 12.4 1.124 14 1 54 3.48 0 2 581.84314 -2.83 20.81 1162.67558

NGNMAGISDQR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 11 1 73858566 N-Term(iTRAQ4plex) 1.211 6 11.2 1.048 6 13.4 1.189 6 4.3 1.209 6 8.2 1.236 6 12.2 1.207 6 18.3 1.049 6 5.5 53 6.09 0 3 749.72815 0.06 61.1 2247.16989

NGNMAGISDQR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 2 1 73858566 N-Term(iTRAQ4plex); M4(Oxidation)

1.156 33 8.3 0.973 33 8.1 1.081 33 12.1 1.104 33 8.4 1.213 33 8.1 1.262 33 6.4 1.149 33 4.4 47 4.06 0 3 427.87805 -0.37 33.16 1281.61882

NGPLSCGQR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 2 1 145275213 N-Term(iTRAQ4plex); C6(Methylthio)

0.967 1 0.72 1 0.753 1 1.046 1 0.911 1 1.265 1 1.209 1 44 0 2 489.7988 0.69 17.22 978.59032

NGQVEIK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 2 1 4502503 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.209 1 1.112 1 1.237 1 1.112 1 1.318 1 1.185 1 1.065 1 42 0 2 504.80286 -1.76 18.78 1008.59844

NGQWSEPPK CFHR1;CFHR2;CFH

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 2 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3080;3075

NP_002104;NP_005657;NP_000177

4 3 118442839;5031695;62739186

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.349 1 0.884 1 1.204 1 1.362 1 1.337 1 1.513 1 1.11 1 40 0 2 476.25214 6.92 23.77 951.497

NGSQTLSPEAGIFINK LOC100653515

differential display clone 8 isoform 1 [Homo sapiens]

100653515 NP_001230470 1 2 343780900 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.869 1 0.917 1 0.764 1 0.834 1 0.902 1 0.984 1 1.181 1 38 7.22 1 3 807.70825 3.01 43.51 2421.1102

NGVAQEPVHLDSPAIK A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 24 1 21071030 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.042 4 12.2 1.007 4 2.1 0.966 4 39.4 1.046 4 24 1.081 4 18.9 1.188 4 8.2 1.172 4 31.9 36 7.88 1 5 1223.3193 2.53 45.93 3667.91944

NGVGVLIWK LYVE1 lymphatic vessel endothelial hyaluronic acid receptor 1 precursor [Homo sapiens]

10894 NP_006682 NP_057248

1 1 40549451 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.236 9 7.6 0.917 9 8 1.096 9 8 1.18 9 4.2 1.214 9 7 1.386 9 7.7 1.131 9 3.8 35 3.4 0 2 552.75092 1 29.64 1104.49516

NHAIFSEDLENLK MTERFD1 mTERF domain-containing protein 1, mitochondrial precursor [Homo sapiens]

51001 NP_057026 1 1 34147676 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.626 1 0.923 1 1.409 1 1.527 1 1.717 1 1.862 1 1.219 1 34 6.19 1 3 807.70825 3.01 43.51 2437.11087

NHFAAGGFFGQGISLPGTPAMDK

MECOM MDS1 and EVI1 complex locus protein EVI1 isoform e [Homo sapiens]

2122 NP_001157472 1 5 255683390 N-Term(iTRAQ4plex); M21(Oxidation); K23(iTRAQ4plex)

1.427 2 1.7 0.965 2 8.9 1.342 2 11.5 1.391 2 2.6 1.462 2 1.2 1.516 2 7.7 1.089 2 10.4 31 0 2 490.755 -0.3 6.93 980.50273

NHLQLEGLFFTNGEHTSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

0.987 1 1.242 1 1.052 1 0.847 1 1.16 1 0.934 1 1.103 1 5.18 1 5 536.10596 10.32 33.43 2676.50068

NHMQYEIVIK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 14 2 156119625 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.101 4 2.3 1.009 4 0.8 1.017 4 2 1.014 4 3.2 1.189 4 0.5 1.175 4 1.7 1.169 4 0.7 4.21 0 2 667.34875 6.93 23.84 1333.69023

NHMQYEIVIK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 6 2 156119625 N-Term(iTRAQ4plex); M3(Oxidation); K10(iTRAQ4plex)

1.14 1 0.941 1 1.026 1 1.091 1 1.186 1 1.26 1 1.155 1 3.44 1 3 498.95078 -9.45 24.52 1494.83777

NHNALLASLTTQK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 2 3 21450863 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.318 2 11.8 0.892 2 24.8 1.189 2 24.3 1.334 2 0.4 1.312 2 22.8 1.472 2 1.8 1.103 2 1.4 33 0 2 493.83148 6.91 16.88 986.65569

NHPVATLMATGHPMVISSDDPAMFGAK

CECR1 adenosine deaminase CECR1 isoform a precursor [Homo sapiens]

51816 NP_059120 2 2 29029550 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

1.963 11 44.1 0.943 11 32.3 1.473 11 59.6 1.576 11 61.5 2.48 11 54.5 2.163 11 55 1.444 11 64.6 99 9.09 0 4 1169.28 1.52 70.12 3505.82216

NHQLIVTR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 4 1 133925809 N-Term(iTRAQ4plex) 1.707 8 5.1 1.027 8 12.5 1.621 8 12.1 1.559 8 6.1 1.838 8 9.2 1.782 8 8.3 1.114 8 1.4 98 6.19 0 2 836.9201 3.1 35.2 1672.83293

NHSCEPCQTLAVR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 1 1 145275213 N-Term(iTRAQ4plex); C4(Methylthio); C7(Methylthio)

2.204 3 23.9 0.631 3 4.8 1.823 3 32.5 2.889 3 11.1 1.771 3 32.9 2.806 3 11.5 0.974 3 0.4 92 8.87 0 3 1308.578 1.23 80.26 3923.71946

NIETIINTFHQYSVK S100A9 protein S100-A9 [Homo sapiens] 6280 NP_002956 2 1 4506773 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.683 3 7.6 1.063 3 17.6 1.526 3 22 1.615 3 4.3 1.747 3 3.2 1.776 3 6 1.145 3 10.3 77 6.54 0 3 616.66479 2.57 38.54 1847.97983

NIFFSPLSISAAYAMLSLGACSHSR

SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 28 1 21361302 N-Term(iTRAQ4plex); C21(Methylthio)

1.345 3 0.9 1.003 3 2.5 1.248 3 7.8 1.245 3 0.4 1.447 3 1.5 1.423 3 3.5 1.171 3 1.8 67 9.1 0 3 718.65643 3.29 47.86 2153.95475

NIFFSPLSISAAYAMLSLGACSHSR

SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 34 1 21361302 N-Term(iTRAQ4plex); M15(Oxidation); C21(Methylthio)

1.87 3 0.8 0.972 3 0.6 1.672 3 14.2 1.631 3 8.6 2.029 3 7.9 1.898 3 2.4 1.213 3 4.3 64 8.58 0 3 818.08667 -4.25 18.14 2452.25187

NIFISPVSISMALAMLSLGTCGHTR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 16 1 73858564 N-Term(iTRAQ4plex); M11(Oxidation); M15(Oxidation); C21(Methylthio)

1.385 5 11.7 0.898 5 13.6 1.157 5 31.8 1.378 5 8.2 1.288 5 31.2 1.507 5 9.9 1.113 5 3.3 63 4.33 0 2 749.82642 1.56 34.73 1498.64556

NIFISPVSISMALAMLSLGTCGHTR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 34 1 73858564 N-Term(iTRAQ4plex); M15(Oxidation); C21(Methylthio)

1.54 3 6.5 0.945 3 5.2 1.346 3 10.1 1.584 3 2.6 1.65 3 7.6 1.753 3 0.6 1.12 3 4.3 55 4.73 0 2 658.82867 -0.28 26.02 1316.65007

NIFISPVSISMALAMLSLGTCGHTR

SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 30 1 73858564 N-Term(iTRAQ4plex); C21(Methylthio)

1.597 4 5.8 1.001 4 17.6 1.548 4 5.8 1.525 4 5.4 1.776 4 4.2 1.732 4 12 1.15 4 4.8 48 3.15 0 2 562.33197 0.48 11.58 1123.65483

NIFNFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.665 7 13.1 1.073 7 3.4 1.641 7 18.9 1.566 7 5.3 1.77 7 21.4 1.719 7 15.8 1.104 7 3.6 47 3.76 0 2 658.37866 0.02 30.78 1315.75005

NIFWTDSNLDR NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 2 1 115298674 N-Term(iTRAQ4plex) 1.418 4 6.1 0.983 4 6.2 1.35 4 3.2 1.314 4 6.3 1.526 4 3.1 1.485 4 7.6 1.123 4 0.8 40 3.87 0 2 676.78204 -1.46 45.92 1352.55925

NIGEFCGK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

25 1 66347875 N-Term(iTRAQ4plex); C6(Methylthio); K8(iTRAQ4plex)

1.92 3 0.8 0.968 3 10.8 1.71 3 5.5 1.791 3 7.6 1.938 3 4.6 1.982 3 3.2 1.133 3 0.9 39 3.8 0 2 603.86908 -1.51 51.35 1206.73247

NIIFVETSFTTLETR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

4 1 256217721 N-Term(iTRAQ4plex) 1.563 1 0.834 1 1.331 1 1.597 1 1.536 1 1.842 1 1.154 1 34 0 2 555.83246 2.38 27.84 1110.65764

NIILPVYDK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.524 2 7.4 0.97 2 10 1.448 2 10.3 1.492 2 0.3 1.557 2 14.2 1.604 2 4.2 1.075 2 3.8 34 2.75 0 2 569.24524 2.5 24.35 1137.47563

NILFVIDVSGSMWGVK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 60 1 70778918 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.409 1 1.017 1 1.366 1 1.343 1 1.476 1 1.452 1 1.081 1 34 3.71 0 2 816.37256 -7.7 40.8 1631.73784

NILFVIDVSGSMWGVK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 26 1 70778918 N-Term(iTRAQ4plex); M12(Oxidation); K16(iTRAQ4plex)

39 0 2 516.80536 6.43 16.41 1032.60344

NILTSNNIDVK APOD apolipoprotein D precursor [Homo sapiens]

347 NP_001638 2 1 4502163 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.078 1 0.93 1 0.997 1 1.072 1 1.083 1 1.165 1 1.086 1 133 5.31 0 2 1054.4802 1.01 14.32 2107.95317

NILVSSAGSR COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 1 5 55743098 N-Term(iTRAQ4plex) 0.85 5 36.8 0.881 5 39.7 0.763 5 28.6 0.88 5 63.9 0.941 5 19.8 0.99 5 47.8 1.157 5 10.2 109 5.5 0 3 1087.8317 2.61 55.99 3261.48044

NIPCAVTK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 4 1 169636415 N-Term(iTRAQ4plex); C4(Methylthio); K8(iTRAQ4plex)

1.139 8 33.4 0.91 8 13.2 1.05 8 36.8 1.084 8 29.7 1.21 8 42.8 1.316 8 34.6 1.359 8 3.9 105 8.76 0 3 1037.8364 0.57 67.77 3111.49472

NIPGDFECECPEGYR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 8 1 192447438 N-Term(iTRAQ4plex); C8(Methylthio); C10(Methylthio)

0.663 11 6.5 0.943 11 14.2 0.597 11 20.2 0.641 11 15.1 0.641 11 17.7 0.673 11 15.7 1.133 11 12 104 6.25 0 3 858.89331 -0.01 21.75 1716.77934

NIPTVNENLENYYLEVNQLEK

LUM lumican precursor [Homo sapiens] 4060 NP_002336 21 1 4505047 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

0.798 1 1.003 1 0.728 1 0.726 1 0.871 1 0.868 1 1.196 1 100 4.39 0 2 941.46765 3.11 19.78 1881.92803

NIQEYLSILTDPDGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 50 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.469 7 23.4 0.889 7 16.6 1.267 7 17.1 1.63 7 20.8 1.379 7 14.6 1.729 7 16.3 1.138 7 4.5 97 7.34 0 3 1213.0785 -0.26 52.68 2425.1572

NIQSLEVIGK PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 22 1 4505981 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.659 1 0.999 1 0.614 1 0.615 1 0.704 1 0.705 1 1.146 1 93 6.72 0 2 1213.0785 -0.26 52.68 2409.16631

NISDGFDGIPDNVDAALALPAHSYSGR

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 2 1 88853069 N-Term(iTRAQ4plex) 1.082 2 23.1 0.996 2 2.2 1.037 2 27 1.041 2 29.3 1.122 2 17.3 1.127 2 19.5 1.083 2 9.4 86 8.35 0 3 781.69849 0.42 40.07 2343.08091

NKEDCVEIYIK SELL L-selectin precursor [Homo sapiens] 6402 NP_000646 4 1 262206315 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C5(Methylthio); K11(iTRAQ4plex)

1.19 1 0.991 1 1.376 1 1.389 1 0.992 1 1.001 1 0.721 1 63 4.01 0 3 1087.8317 2.61 55.99 3277.46848

NKLNDLEDALQQAKEDLAR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 2 2 119395750 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K14(iTRAQ4plex)

0.984 1 0.948 1 0.868 1 0.915 1 1.049 1 1.106 1 1.209 1 62 4.3 0 2 714.88708 6.7 16.43 1428.76689

NKPGVYTDVAYYLAWIR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 22 1 145275213 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.908 8 15.2 1.04 8 6.7 1.801 8 18.1 1.744 8 12.4 2.066 8 14.7 1.997 8 11.4 1.135 8 2.5 59 3.59 0 2 579.79773 0.06 12.1 1158.58818

NLAVSQVVHK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 30 1 50659080 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.116 1 1.039 1 1.082 1 1.042 1 1.193 1 1.149 1 1.102 1 57 6.28 0 3 591.97949 -2.64 43.73 1773.92392

NLAVSQVVHKAVLDVFEEGTEASAATAVK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 3 1 50659080 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K29(iTRAQ4plex)

0.887 2 2.3 0.978 2 3.7 0.817 2 4.1 0.835 2 7.8 0.938 2 2.8 0.958 2 0.9 1.148 2 6.9 52 4.67 0 3 404.57153 1.13 10.46 1211.70188

NLCEAMENFMQQLK C4BPB C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

725 NP_001017364 11 2 62912462 N-Term(iTRAQ4plex); C3(Methylthio); K14(iTRAQ4plex)

1.841 3 13.7 0.956 3 11.6 1.655 3 18.8 1.731 3 7 1.946 3 20.2 2.036 3 8.4 1.176 3 1.1 50 3.54 0 2 667.8269 0.61 14.68 1334.64849

NLCEAMENFMQQLK C4BPB C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

725 NP_001017364 2 2 62912462 N-Term(iTRAQ4plex); C3(Methylthio); M10(Oxidation); K14(iTRAQ4plex)

1.316 1 0.879 1 1.182 1 1.345 1 1.291 1 1.469 1 1.092 1 49 8 0 3 870.42365 -0.57 37.1 2609.25638

NLDENYCR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 14 1 4505881 N-Term(iTRAQ4plex); C7(Methylthio)

2.86 1 1.086 1 2.829 1 2.605 1 3.137 1 2.889 1 1.109 1 40 0 2 522.3075 -4.89 16.71 1043.60771

NLDFSVIVANK DSG2 desmoglein-2 preproprotein [Homo sapiens]

1829 NP_001934 1 1 116534898 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.495 1 0.966 1 0.435 1 0.45 1 0.538 1 0.557 1 1.237 1 36 2.89 0 2 603.80792 -0.52 32.49 1206.60857

NLDILEGAITSAADQGAHIIVTPEDAIYGWNFNR

VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 4 1 223633991 N-Term(iTRAQ4plex) 2.181 1 1.138 1 2.37 1 2.082 1 2.295 1 2.016 1 0.968 1 30 5.61 0 4 544.99683 -0.05 8.52 2176.96547

NLDLDSIIAEVK KRT5;KRT6A;KRT2

keratin, type II cytoskeletal 5 [Homo sapiens];keratin, type II cytoskeletal 6A [Homo sapiens];keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3852;3853;3849

NP_000415;NP_005545 NP_490596;NP_000414

8 8 119395754;5031839;47132620

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.593 1 0.921 1 0.537 1 0.583 1 0.602 1 0.654 1 1.122 1 3.67 0 3 625.3728 5.55 27.32 1874.10385

NLDLDSIIAEVKAQYEEIAQR KRT6A;KRT2

keratin, type II cytoskeletal 6A [Homo sapiens];keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3853;3849 NP_005545 NP_490596;NP_000414

4 5 5031839;47132620

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.064 1 1.054 1 2.04 1 1.936 1 2.199 1 2.087 1 1.078 1 2.82 0 2 658.84814 -15.09 18.23 1316.68901

NLELGLTQGSFAFIHK SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 4 1 7705879 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.2 1 1.021 1 1.176 1 1.152 1 1.249 1 1.224 1 1.062 1 2.8 0 2 463.2471 1.02 13.54 925.48693

NLEVTETFDGEVSLAWEEPLTDGGSK

TTN titin isoform N2-A [Homo sapiens] 7273 NP_596869 2 5 291045225 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.603 3 5.5 1.055 3 8.3 1.548 3 13.7 1.467 3 1.2 1.746 3 6.3 1.637 3 0.5 1.125 3 0.4 87 4.78 0 2 803.42096 -5.64 38.54 1605.84038

NLGFYTDQAFGELEK HERC1 probable E3 ubiquitin-protein ligase HERC1 [Homo sapiens]

8925 NP_003913 1 1 126131099 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.428 3 30.3 1.098 3 0.8 1.396 3 13.7 1.272 3 52.3 1.6 3 8.2 1.458 3 33.4 1.147 3 5.4 76 4.8 0 2 822.94397 -1.78 32.44 1644.87383

NLHDLDVSDNQLER VASN vasorin precursor [Homo sapiens] 114990 NP_612449 8 1 88702793 N-Term(iTRAQ4plex) 1.061 2 22.7 0.573 2 4.5 0.694 2 2.4 1.211 2 6.9 0.966 2 35 1.685 2 40 1.392 2 32.4 67 8.18 0 3 1016.8878 0.56 80.89 3048.6489NLIAAVAPGAFLGLK IGFALS insulin-like growth factor-binding

protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 11 2 4826772 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.217 1 0.735 1 1.071 1 1.457 1 1.041 1 1.416 1 0.972 1 59 7.34 0 3 1016.8878 0.56 80.89 3064.64298

NLIAVLGEHDLSEHDGDEQSR

F7 coagulation factor VII isoform b precursor [Homo sapiens]

2155 NP_062562 1 2 10518503 N-Term(iTRAQ4plex) 1.33 2 5.1 0.886 2 23.2 1.203 2 5.3 1.358 2 28.8 1.307 2 15.8 1.476 2 7.2 1.087 2 21.3 59 4.86 0 3 607.98071 -0.92 76.06 1821.92705

NLLFNDNTECLAR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex); C10(Methylthio)

1.205 2 12.9 1.036 2 19.5 1.175 2 23.4 1.135 2 3.7 1.284 2 22.7 1.24 2 3.1 1.092 2 0.6 55 3.85 0 2 683.38153 -7.23 23.15 1365.75578

NLLHVTDTGVGMTR HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 2 1 4507677 N-Term(iTRAQ4plex) 1.235 2 10.9 0.948 2 1.2 1.141 2 13.6 1.203 2 12.4 1.266 2 9.7 1.335 2 8.5 1.11 2 3.9 43 5.3 0 3 787.01178 -4.63 27.53 1573.02115

NLNAPVQPFEDPEHMK LRP1 prolow-density lipoprotein receptor-related protein 1 precursor [Homo sapiens]

4035 NP_002323 1 1 126012562 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.304 1 0.914 1 1.209 1 1.322 1 1.287 1 1.409 1 1.065 1 40 4.47 0 3 597.65881 8.4 22.14 1790.96189

NLPATDPLQR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 2 2 221316614 N-Term(iTRAQ4plex) 0.6 1 1.329 1 0.682 1 0.513 1 0.716 1 0.539 1 1.05 1 37 0 2 541.29871 -1.79 21.64 1081.59014

NLQNNAEWVYQGAIR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 38 1 105990532 N-Term(iTRAQ4plex) 1.461 2 4.1 0.985 2 19.2 1.381 2 15.7 1.402 2 3.4 1.525 2 11.8 1.548 2 7.3 1.104 2 3.9 35 3.6 0 2 608.34497 -3.05 32.18 1215.68389

NLQPASEYTVSLVAIK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

53 5 47132549;16933542

N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.378 2 11.5 0.911 2 38.4 1.197 2 31.1 1.314 2 6.7 1.456 2 28.6 1.598 2 9.1 1.216 2 2.4 4.41 1 3 687.05798 -4.55 41.89 2059.1594

NLTDFAEQYSIQDWAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 26 1 105990532 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.605 1 0.969 1 1.53 1 1.58 1 1.63 1 1.683 1 1.065 1 3.02 0 2 505.77518 4.28 24.76 1010.54308

NLVTMTTAPR AOC3 membrane primary amine oxidase [Homo sapiens]

8639 NP_003725 2 1 4502119 N-Term(iTRAQ4plex) 1.605 1 1.021 1 1.544 1 1.512 1 1.7 1 1.665 1 1.101 1 27 0 2 512.83392 -3.83 21.44 1024.66057

NLVTMTTAPR AOC3 membrane primary amine oxidase [Homo sapiens]

8639 NP_003725 1 1 4502119 N-Term(iTRAQ4plex); M5(Oxidation)

1.128 1 0.91 1 1.005 1 1.104 1 1.149 1 1.262 1 1.143 1 42 6.59 0 3 908.46539 0.31 54.14 2723.38163

NLYFTDWK NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 4 1 115298674 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.281 4 11.7 0.929 4 4.9 1.178 4 15.9 1.267 4 12.9 1.294 4 10.7 1.363 4 10.8 1.099 4 5.2 101 5.89 0 3 1053.0936 3.61 42.24 2105.18497

NMEQFQVSVSVAPNAK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

70 2 31542984;262050538

N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.313 3 11.1 1.026 3 15.2 1.299 3 11.5 1.131 3 4.7 1.427 3 9.3 1.305 3 7.6 1.098 3 0.1 99 5.78 0 2 959.40619 -0.15 22.47 1917.8051

NMEQFQVSVSVAPNAK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

21 2 31542984;262050538

N-Term(iTRAQ4plex); M2(Oxidation); K16(iTRAQ4plex)

1.229 2 1.3 0.713 2 23.3 0.978 2 14 1.372 2 9.1 1.132 2 3.5 1.589 2 19.7 1.158 2 10.5 77 5.33 0 3 740.4433 1.31 21.47 1479.88199

NMEVFFPK SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 2 1 7705879 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.246 6 13.5 0.931 6 10.6 1.159 6 28.1 1.264 6 11.1 1.245 6 20.6 1.427 6 12.5 1.17 6 6.4 73 7.32 0 3 1235.0714 -2.14 42.27 2469.13932

NMEVSVATTTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.612 1 0.987 1 1.481 1 1.499 1 1.724 1 1.746 1 1.164 1 71 5.29 0 2 814.44177 -1.17 22.83 1627.87627

NMEVSVATTTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 19 1 105990532 N-Term(iTRAQ4plex); M2(Oxidation); K11(iTRAQ4plex)

1.156 2 3.2 0.881 2 6.5 1.054 2 3.9 1.197 2 10.5 1.12 2 3.4 1.271 2 3.1 1.062 2 7.3 63 8.02 0 3 890.47736 2.96 63.24 2669.4144

NMQDLVEDFK KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 5 1 119395754 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.118 3 21.8 1.153 3 4.1 1.125 3 5.5 0.949 3 1.4 1.323 3 15.3 1.148 3 49 1.212 3 1.2 59 7.16 0 3 858.77576 1.52 38.79 2574.30997

NMQDMVEDYR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 9 2 119395750 N-Term(iTRAQ4plex) 1.387 2 10.5 0.9 2 3.4 1.226 2 11.9 1.363 2 8.5 1.408 2 12.3 1.565 2 8.9 1.149 2 0.4 57 4.25 0 2 754.88312 -1.65 52.06 1508.75896

NMQDMVEDYR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 7 2 119395750 N-Term(iTRAQ4plex); M5(Oxidation)

0.97 1 0.934 1 0.89 1 0.953 1 0.987 1 1.056 1 1.108 1 47 3.87 0 2 1034.984 -10.44 25.56 2068.96074

NMQDMVEDYR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 1 2 119395750 N-Term(iTRAQ4plex); M2(Oxidation); M5(Oxidation)

0.954 1 0.948 1 0.899 1 0.948 1 0.959 1 1.012 1 1.067 1 42 4.15 0 2 710.31177 0.62 48.1 1419.61626

NNALDFVTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.094 2 8.4 0.998 2 11 1.046 2 15.4 1.048 2 4.4 1.141 2 12.6 1.143 2 1.6 1.091 2 2.8 34 3.72 0 2 639.79657 -6.31 37.38 1278.58586

NNEEYLALIFEK QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

4 2 13325075 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.083 2 5.8 0.971 2 7.5 0.997 2 9.8 1.027 2 2.3 1.138 2 9.3 1.172 2 1.7 1.141 2 0.5 32 3.39 0 2 623.29785 1.29 30.69 1245.58599

NNEGTYYSPNYNPQSR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 39 1 4557485 N-Term(iTRAQ4plex) 0.582 1 0.968 1 0.539 1 0.557 1 0.606 1 0.627 1 1.125 1 28 3.44 0 2 606.29773 0.06 42.8 1211.58818

NNFLPNADMETRRGAYLNALK

USP9X probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 4 [Homo sapiens]

8239 NP_001034680 1 2 145309311 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.334 52 11.2 0.939 52 16 1.227 52 16 1.253 52 14.6 1.388 52 17.5 1.431 52 14.3 1.135 52 11.4 101 6.2 0 3 1057.0532 2.26 66.85 2113.09917

NNLELSTPLK PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 6 1 192447438 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.183 45 7.2 0.936 45 7.1 1.072 45 7.1 1.136 45 8.5 1.241 45 8.7 1.327 45 10.4 1.158 45 4.3 89 5.74 0 2 817.901 0.95 34.59 1634.79363

NNNTDLMILK PSMD1 26S proteasome non-ATPase regulatory subunit 1 isoform 2 [Homo sapiens]

5707 NP_001177966 2 2 300388183 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.252 22 4.4 0.966 22 13.2 1.162 22 6.8 1.197 22 5.2 1.304 22 11.1 1.329 22 6.8 1.118 22 5.4 86 5.53 0 2 913.95123 1.22 64.57 1826.89519

NNQIDHIDEK LUM lumican precursor [Homo sapiens] 4060 NP_002336 4 1 4505047 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.925 17 8.2 0.928 17 12.1 0.835 17 13.4 0.951 17 7 0.897 17 10.5 1.007 17 13.1 1.131 17 4.1 72 8.38 0 3 716.04272 4.74 53.41 2146.11362

NNVPCSPK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

11 6 178557739;67190748

N-Term(iTRAQ4plex); C5(Methylthio); K8(iTRAQ4plex)

1.305 5 12.2 0.954 5 11.8 1.196 5 15.4 1.224 5 4.2 1.353 5 18.8 1.365 5 4.6 1.145 5 1.7 68 3.78 0 3 352.19781 2.54 12.73 1054.57944

NNVPCSPKVDFTLSSER C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex); C5(Methylthio); K8(iTRAQ4plex)

1.266 7 20.8 1.014 7 6.7 1.147 7 17.6 1.091 7 21 1.4 7 28.1 1.413 7 12.5 1.127 7 6.6 62 8.2 0 3 1257.6884 -2.15 40.99 2514.37387

NNVVITVTQR CD109 CD109 antigen isoform 3 precursor [Homo sapiens]

135228 NP_001153060 2 3 227430303 N-Term(iTRAQ4plex) 1.183 11 6.7 1.025 11 3.3 1.099 11 12.8 1.096 11 6.8 1.274 11 4.4 1.224 11 5.5 1.131 11 4.9 56 5.16 1 3 904.94012 1.98 18.53 1808.85862

NNVVSVNK TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.134 10 13.2 1.029 10 12 1.08 10 19.1 0.971 10 8.7 1.25 10 15.1 1.241 10 14.2 1.131 10 11 56 5.46 1 3 475.61063 2.97 35.79 1424.81733

NPAYEVDVQAR PCDH12 protocadherin-12 precursor [Homo sapiens]

51294 NP_057664 2 1 7706113 N-Term(iTRAQ4plex) 1.028 5 5.2 0.957 5 6.3 0.941 5 2.4 0.98 5 4.8 1.06 5 6.3 1.117 5 8 1.096 5 10.3 54 3.45 0 3 422.86948 -4.26 26.57 1266.59937

NPCQDPYILTPENR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 8 1 86788015 N-Term(iTRAQ4plex); C3(Methylthio)

1.333 7 24.9 0.829 6 41.1 0.962 7 13.2 1.4 6 22.8 1.341 7 15.3 1.82 6 34.1 1.342 7 9.4 54 8.37 1 3 929.54095 13.08 34.81 2786.5997

NPDADEKPWCFIK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 7 2 295054188 N-Term(iTRAQ4plex); K7(iTRAQ4plex); C10(Methylthio); K13(iTRAQ4plex)

1.572 11 8.8 0.925 11 10 1.4 11 9 1.55 11 12.7 1.573 11 10.1 1.691 11 7.8 1.109 11 13.6 53 7.83 0 3 716.04272 4.74 53.41 2162.11136

Page 31: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

NPDADKGPWCFTTDPSVR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 33 1 4505881 N-Term(iTRAQ4plex); K6(iTRAQ4plex); C10(Methylthio)

1.153 11 20.6 1.059 11 18.9 1.129 11 21.2 1.091 11 16.4 1.264 11 19 1.29 11 11.5 1.119 11 3.2 50 3.32 0 2 537.84003 -3.14 20.46 1074.6779

NPDGDPGGPWCYTTDPAVR

MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 5 1 205277383 N-Term(iTRAQ4plex); C11(Methylthio)

2.275 7 216.9 0.928 7 5.4 1.995 7 165.9 2.18 7 186.9 2.362 7 249 2.582 7 218.8 1.13 7 8.6 49 6.66 0 3 1385.6992 -3.82 20.67 2770.43534

NPDGDSHGPWCYTMDPR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 4 1 205277383 N-Term(iTRAQ4plex); C11(Methylthio)

1.248 7 1.2 0.934 7 11.8 1.127 7 6.8 1.215 7 3.7 1.287 7 4.8 1.37 7 4.6 1.142 7 2.5 47 3.82 0 2 786.32227 -0.2 42.78 1571.63701

NPDGDSHGPWCYTMDPR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); C11(Methylthio); M14(Oxidation)

1.112 3 13.1 1.001 3 3.1 1.067 3 7.6 1.121 3 2.2 1.182 3 15.1 1.306 3 2.4 1.165 3 0.2 46 4.74 1 2 922.41675 -4.55 20.1 1843.83733

NPDGDVGGPWCYTTNPR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 20 1 4505881 N-Term(iTRAQ4plex); C11(Methylthio)

1.185 11 3 0.996 11 6 1.113 11 8.8 1.126 11 4.1 1.234 11 5.1 1.248 11 3.5 1.122 11 3.1 45 3.9 0 3 423.57437 -2.69 59.28 1268.70856

NPDGSEAPWCFTLRPGMR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 3 1 205277383 N-Term(iTRAQ4plex); C10(Methylthio)

1.44 2 24.8 0.906 2 9.4 1.299 2 29.1 1.433 2 19.3 1.449 2 29.9 1.598 2 20 1.116 2 0.7 44 4.43 0 2 687.31366 8.01 34.8 1373.62004

NPDGSERPWCYTTDPQIER MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 4 1 205277383 N-Term(iTRAQ4plex); C10(Methylthio)

1.011 2 6.2 0.97 2 2.1 0.974 2 10.2 1.004 2 8.1 1.017 2 4.5 1.048 2 2.3 1.044 2 5.7 40 4.43 0 3 782.43036 -3.54 18.32 1563.85453

NPDNDERPWCYVVK HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 2 1 4504383 N-Term(iTRAQ4plex); C10(Methylthio); K14(iTRAQ4plex)

1.984 2 12.8 0.956 2 2.3 1.829 2 22 1.914 2 19.6 2.046 2 6.8 2.141 2 4.5 1.118 2 15.1 47 5.49 0 3 558.98535 0.4 19.32 1674.93894

NPDNDIRPWCFVLNR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 5 1 145275213 N-Term(iTRAQ4plex); C10(Methylthio)

0.421 1 1.01 1 0.396 1 0.392 1 0.451 1 0.446 1 1.14 1 105 4.75 0 2 831.46008 -4.31 25.95 1661.91289

NPDNDPQGPWCYTTDPEK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 24 1 4505881 N-Term(iTRAQ4plex); C11(Methylthio); K18(iTRAQ4plex)

1.208 3 0.9 1.191 3 3.1 1.176 3 9.2 1.065 3 9.1 1.339 3 6.6 1.248 3 7.6 1.16 3 13.9 60 4.83 1 4 901.01593 10.41 18.2 1801.0198

NPDNDPQGPWCYTTDPEKR

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 13 1 4505881 N-Term(iTRAQ4plex); C11(Methylthio); K18(iTRAQ4plex)

1.205 14 4.7 0.94 14 11 1.075 14 10.5 1.136 14 10.2 1.262 14 6.3 1.314 14 6.6 1.17 14 8.4 58 3.64 0 3 372.86407 0.96 6.33 1116.57804

NPDSSTTGPWCYTTDPTVR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 35 1 4503635 N-Term(iTRAQ4plex); C11(Methylthio)

1.139 9 6 0.924 9 15.6 1.048 9 7.3 1.151 9 3 1.19 9 11 1.302 9 6.4 1.135 9 7.8 45 3.29 0 2 516.26569 0.23 7.01 1031.5241

NPFVFAPTLLTVAVHFEEVAK

AFM afamin precursor [Homo sapiens] 173 NP_001124 40 1 4501987 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

110 5.49 0 2 721.8587 -8.37 15.35 1442.71013

NPLPSK TMSB4X thymosin beta-4 [Homo sapiens] 7114 NP_066932 3 1 11056061 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

107 9.26 0 3 809.76569 -1.35 37.1 2427.2825

NPLVWVHASPEHVVVTR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

30 2 31542984;262050538

N-Term(iTRAQ4plex) 99 5.89 0 2 916.9104 0.14 16.71 1832.82195

NPNGYSFSIPVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

93 6.8 0 2 1009.9955 1.78 21.12 2018.98369

NPNLPPETVDSLK APOD apolipoprotein D precursor [Homo sapiens]

347 NP_001638 2 1 4502163 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

90 5.75 0 3 1192.5981 0.87 69.85 2384.19243

NPNPSAPR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 5 2 115583663 N-Term(iTRAQ4plex) 89 4.46 0 2 830.92004 0.63 47.8 1660.82744

NPPLRNVASEGEGQILEPIGTESK

TRPS1 zinc finger transcription factor Trps1 [Homo sapiens]

7227 NP_054831 1 1 90652851 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

89 5.31 0 2 770.3988 -1.97 27.82 1539.78545

NPSDPMPQAPALWIETTAYALLHLLLHEGK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

6 6 178557739;67190748

N-Term(iTRAQ4plex); M6(Oxidation); K30(iTRAQ4plex)

88 5.18 0 3 858.73114 2.59 70.58 2574.17887

NPSSAGSWNSGSSGPGSTGNR

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex) 84 5.71 0 2 938.96008 -2.51 41.34 1876.91928

NQDVHSINLPFFETLQEYFER

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 154 1 105990532 N-Term(iTRAQ4plex) 80 7.4 1 3 1328.7007 3.81 44.62 2656.39409

NQEACELSNN APOM;APOM

apolipoprotein M isoform 2 [Homo sapiens];apolipoprotein M isoform 2 [Homo sapiens]

55937;55937

NP_001243098;NP_001243098

2 2 22091452;371873523

N-Term(iTRAQ4plex); C5(Methylthio)

74 6.86 0 3 1121.5891 -0.07 56.49 2242.17533

NQECIALPENICGIGWHLVGNSCLK

ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 17 3 21450863 N-Term(iTRAQ4plex); C4(Methylthio); C12(Methylthio); C23(Methylthio); K25(iTRAQ4plex)

71 6.64 0 4 1623.115 4.9 65.71 4867.32973

NQFNDYTSK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 4 1 4557351 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

68 7.99 1 3 838.79907 5.78 50.11 2514.38266

NQGILEFYGDDIALLK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 22 3 14550407 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

67 3.89 0 3 383.22922 2.3 38.93 1147.6731

NQGNTWLTAFVLK A2M;PZP alpha-2-macroglobulin precursor [Homo sapiens];pregnancy zone protein precursor [Homo sapiens]

2;5858 NP_000005;NP_002855

8 2 66932947;162809334

N-Term(iTRAQ4plex); K13(iTRAQ4plex)

67 7.15 1 3 764.39514 -2.73 17.08 2291.17087

NQILNLTTDNANILLQIDNAR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

4 2 195972866 N-Term(iTRAQ4plex) 65 6.68 0 3 1121.5891 -0.07 56.49 2258.17014

NQLTSNPENTVFDAK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 2 1 16507237 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

63 4.61 1 2 799.91547 0.2 15.35 1598.82366

NQNAPDSRPEENFFSRLDSSLK

UPF2 regulator of nonsense transcripts 2 [Homo sapiens]

26019 NP_542166 1 1 18375676 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

61 4.31 0 2 677.32867 8.82 15.32 1353.63298

NQVVIAAGR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 9 1 29171717 N-Term(iTRAQ4plex) 59 6.11 1 3 838.79907 5.78 50.11 2546.35306

NSCPPTSELLGTSDR GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 11 1 6006001 N-Term(iTRAQ4plex); C3(Methylthio)

59 4.09 0 2 703.82275 4.22 24.6 1406.63396

NSDKDIFGDACDNCLSVLNNDQK

THBS4 thrombospondin-4 precursor [Homo sapiens]

7060 NP_003239 2 1 31543806 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C11(Methylthio); C14(Methylthio); K23(iTRAQ4plex)

58 4.61 0 3 402.22778 -1.66 16.97 1204.6688

NSEEFAAAMSR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 17 1 105990532 N-Term(iTRAQ4plex) 58 2.93 0 2 610.35052 1.02 15.91 1219.68938

NSEEFAAAMSR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 17 1 105990532 N-Term(iTRAQ4plex); M9(Oxidation)

57 3.05 0 2 494.81662 -13.56 14.57 988.62596

NSEGQFFSSMTLWGLAMKTLQNENELDQ

ZBTB49 zinc finger and BTB domain-containing protein 49 [Homo sapiens]

166793 NP_660334 1 1 223972645 N-Term(iTRAQ4plex); M17(Oxidation); K18(iTRAQ4plex)

54 5.22 0 3 1121.5891 -0.07 56.49 2274.15964

NSGLTEEEAK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 4 1 169636415 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

49 8.2 1 3 978.50323 1.68 42.62 2933.49515

NSISDDRLETQSLPSR PTPN4 tyrosine-protein phosphatase non-receptor type 4 [Homo sapiens]

5775 NP_002821 1 1 4506295 N-Term(iTRAQ4plex) 47 3.22 0 2 488.30667 -1.71 14.27 975.60607

NSITLTNLTPGTEYVVSIVALNGR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex) 45 0 2 475.79239 1.49 10.52 950.5775

NSLFEYQK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 1 2 4503689 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

43 6.45 1 3 838.79907 5.78 50.11 2530.36667

NSLFFSAQPFEITASTNNEGNLK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 35 1 105990532 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

43 4.61 1 3 482.9455 -8.88 28.6 1446.83924

NSQWICSNEECPGECLVTGQSHFK

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C6(Methylthio); C11(Methylthio); C15(Methylthio); K24(iTRAQ4plex)

35 3.27 0 2 587.82147 -1.77 75.16 1174.63567

NSVLEVIAYSSSETPNRHDMLLVEPLNR

TRPV1 transient receptor potential cation channel subfamily V member 1 [Homo sapiens]

7442 NP_542435 1 1 74315348 N-Term(iTRAQ4plex) 23 0 2 492.22189 -5.15 30.25 983.43651

NTASLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.84 1 0.909 1 0.774 1 0.852 1 0.83 1 0.913 1 1.072 1 65 4.57 0 2 728.94708 0.87 64.88 1456.88689

NTCNHDEDTWVECEDPFDLR

CD5L CD5 antigen-like precursor [Homo sapiens]

922 NP_005885 7 1 5174411 N-Term(iTRAQ4plex); C3(Methylthio); C13(Methylthio)

1.111 1 0.974 1 1.005 1 1.033 1 1.186 1 1.218 1 1.18 1 64 4.1 0 2 695.40283 -2.65 51.39 1389.79839

NTEILTGSWSDQTYPEGTQAIYK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 95 2 62739186 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

0.355 1 0.955 1 0.325 1 0.34 1 0.37 1 0.387 1 1.139 1 55 4.95 0 2 665.3974 1.23 37.89 1329.78752

NTEQEEGGEAVHEVEVVIK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 10 1 4503625 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.089 1 0.885 1 0.064 1 0.072 1 0.104 1 0.117 1 1.63 1 39 0 2 510.80588 5.11 33.45 1020.60448

NTFAEVTGLSPGVTYYFK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

33 5 47132549;16933542

N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.098 12 15.5 1.102 12 18.2 1.111 12 18.3 0.939 12 19 1.244 12 15.5 1.108 12 11.4 1.115 12 8.4 91 7.67 0 3 1412.7366 1.8 46.65 2824.46665

NTFTLSCDGSLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 12 1 105990532 N-Term(iTRAQ4plex); C7(Methylthio)

0.901 11 9.6 0.928 11 14.3 0.835 11 9.5 0.867 11 17.9 0.987 11 8.2 0.981 11 16.1 1.135 11 13.3 82 5.58 0 3 604.99097 -1.62 59.16 1812.95835

NTLELSNGVIVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.942 1 1.167 1 0.979 1 0.838 1 1.062 1 0.91 1 1.085 1 82 8.18 0 3 967.52307 5.15 60.67 2900.55466

NTLIIYLDK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 18 1 115298678 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.919 5 4.5 0.875 5 13.5 0.806 5 10.1 0.841 5 13.5 1.028 5 2.6 1.047 5 19.8 1.139 5 4.6 79 3.75 0 2 656.89899 0.41 21.65 1312.78252

NTMILEICTR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 22 1 115298678 N-Term(iTRAQ4plex); C8(Methylthio)

0.9 20 12.4 0.896 20 8.9 0.865 20 18.6 0.889 20 11.6 0.908 20 14.5 0.967 20 7.5 1.149 20 7.2 74 5.19 0 2 972.45544 0.11 43.83 1943.90361

NTMILEICTR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 8 1 115298678 N-Term(iTRAQ4plex); M3(Oxidation); C8(Methylthio)

1.156 13 15.3 1.027 13 12.8 1.085 13 13.4 1.038 13 9.2 1.214 13 18.1 1.148 13 14.8 1.134 13 2.9 71 4.02 0 2 757.41028 -0.54 27.25 1513.81401

NTPIDGK C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 6 1 4557391 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.023 18 18.6 1.023 18 16.9 0.929 18 17.3 0.885 18 13.2 1.052 18 27.1 1.082 18 23.5 1.135 18 5.7 68 6.7 0 3 749.10742 1.36 71.37 2245.30327

NTPPTDSPSK FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 2 1 58331240 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.907 12 12.7 1.072 12 7.7 0.882 12 11.8 0.831 12 10.1 1.001 12 15.8 0.938 12 7 1.12 12 7.1 66 3.59 0 2 633.38849 -0.84 26.92 1265.7697

NVAFVIDISGSMAGR ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 96 1 133925809 N-Term(iTRAQ4plex) 1.14 3 14.9 0.838 3 6.9 1.013 3 11.1 1.111 3 8.4 1.169 3 20.9 1.214 3 2.9 1.156 3 11.3 62 2.96 0 2 656.89899 0.41 21.65 1328.77397

NVHLFATPLAASLEEVAPGAR

FLT4 vascular endothelial growth factor receptor 3 isoform 2 precursor [Homo sapiens]

2324 NP_002011 2 2 103472027 N-Term(iTRAQ4plex) 1.05 4 12 1.058 4 22.1 1.069 4 10.9 0.938 4 18.6 1.135 4 10.9 0.991 4 15.9 1.086 4 4.4 59 5.64 1 3 805.97198 -6.91 19.5 1610.95053

NVHSAGAAGSR ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700 NP_002209 27 1 262050538 N-Term(iTRAQ4plex) 0.918 2 0.8 0.975 2 3 0.855 2 1.4 0.877 2 1.6 0.958 2 0 0.983 2 3.1 1.121 2 1.4 56 5.03 0 3 757.39722 1.47 13.16 1513.79001

NVHSGSTFFK ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700 NP_002209 2 1 31542984 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.85 5 10.7 1.048 5 16.1 0.822 5 17.1 0.808 5 4.4 0.918 5 25.5 0.876 5 7.4 1.125 5 1.1 54 4.74 1 3 442.25638 -4.58 23.9 1324.75458

NVLELSNVVR PTPRF receptor-type tyrosine-protein phosphatase F isoform 2 precursor [Homo sapiens]

5792 NP_569707 2 2 109633039 N-Term(iTRAQ4plex) 0.993 2 27.8 1.014 2 6 0.931 2 22.7 0.919 2 29 1.068 2 26.2 1.054 2 32.6 1.147 2 3.4 48 5.59 0 3 529.29779 -0.01 18.71 1585.88028

NVLVTLYER SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 5 1 4507171 N-Term(iTRAQ4plex) 1.627 1 0.979 1 1.526 1 1.559 1 1.694 1 1.731 1 1.111 1 38 0 2 972.45544 0.11 43.83 1959.89849

NVLVTLYERDEDNNLLTEK SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 1 1 4507171 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.867 5 7.8 0.963 5 8.7 0.791 5 9 0.873 5 4.3 0.922 5 11.3 1 5 10.3 1.146 5 3.7 3.56 0 2 584.83319 -0.37 49.36 1168.65911

NVNFQK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

3 6 178557739;67190748

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.166 2 1.1 0.882 2 15.1 1.036 2 9.6 1.175 2 5.4 1.161 2 6.8 1.316 2 8.3 1.121 2 2.8 56 4.26 0 2 684.38263 -5.93 33.25 1367.75798

NVPNCGR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

1 4 34734066;34734062

N-Term(iTRAQ4plex); C5(Methylthio)

1.011 2 11.7 0.993 2 19.5 0.946 2 22.5 0.952 2 2.9 1.074 2 20.8 1.081 2 1.2 1.136 2 1.7 41 3.17 0 2 591.87848 0.65 41.43 1182.74431

NVQALEIELQSQLALK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

38 2 195972866 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.975 1 0.927 1 0.858 1 0.926 1 1.021 1 1.101 1 1.189 1 40 0 2 563.828 -1.06 30.82 1126.64873

NVQDAIADAEQR KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 6 2 47132620 N-Term(iTRAQ4plex) 1.319 1 1.089 1 1.292 1 1.187 1 1.464 1 1.344 1 1.133 1 34 3.63 0 2 688.35193 2.29 23.75 1375.69658

NVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 17 1 70778918 N-Term(iTRAQ4plex); K33(iTRAQ4plex)

0.93 1 0.892 1 0.844 1 0.946 1 0.915 1 1.026 1 1.084 1 2.76 0 2 624.84521 -2.1 57.28 1248.68315

NVVFVIDISGSMR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 116 3 156119625 N-Term(iTRAQ4plex) 1.134 2 2.5 0.961 2 9.6 1.091 2 4.1 1.135 2 5.5 1.132 2 10.2 1.179 2 0.7 1.038 2 6.1 35 2.97 0 2 696.32941 -0.93 34.73 1391.65154

NVVFVIDISGSMR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 1 3 156119625 N-Term(iTRAQ4plex); M12(Oxidation)

1.239 1 0.942 1 1.12 1 1.189 1 1.287 1 1.366 1 1.149 1 33 0 2 547.33521 -1.56 29.44 1093.66313

NVVFVIDK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

139 2 31542984;262050538

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.785 1 0.811 1 1.562 1 1.925 1 1.671 1 2.059 1 1.07 1 51 4.54 0 2 853.92688 -4.99 35.8 1706.84648

NVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRK

POLG2 DNA polymerase subunit gamma-2, mitochondrial [Homo sapiens]

11232 NP_009146 1 1 70887790 N-Term(iTRAQ4plex); C5(Methylthio); M17(Oxidation); K35(iTRAQ4plex)

3.135 2 13.5 0.993 2 10.7 2.937 2 19.7 2.957 2 8.9 3.315 2 18.3 3.337 2 7.5 1.129 2 1.3 49 3.98 0 2 716.85767 4.15 25.26 1432.70806

NVVVACENGLPVHLDQSIFR

ANG angiogenin precursor [Homo sapiens]

283 NP_001136 4 1 4557313 N-Term(iTRAQ4plex); C6(Methylthio)

33 2.89 0 2 569.81519 0.53 37.55 1138.62309

NVVYTCNEGYSLIGNPVAR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 10 1 45580688 N-Term(iTRAQ4plex); C6(Methylthio)

3.8 0 2 652.84949 0.65 47.38 1304.6917

NWETEITAQPDGGK CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 12 1 156627579 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.846 1 0.804 1 0.774 1 0.962 1 0.753 1 0.937 1 0.974 1 49 4.92 0 3 676.34576 3.2 19.03 2027.02274

NWGLGGHAFCR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 2 1 145275213 N-Term(iTRAQ4plex); C10(Methylthio)

1.021 11 10.1 0.967 11 14.1 1.002 11 15.7 0.97 11 10.4 1.133 11 9.7 1.053 11 9.9 1.138 11 3.8 69 4.83 0 2 805.9444 -4.56 45.38 1610.88774

NWGLSVYADKPETTK ORM1 alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5004 NP_000598 4 1 167857790 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K15(iTRAQ4plex)

1.104 2 9.5 0.907 2 8.9 0.989 2 5.7 1.091 2 14.7 1.116 2 4.7 1.231 2 13.7 1.128 2 1 32 4.71 1 3 628.36493 -3.01 33.5 1883.08023

NWMNSLGVNPR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 1 167614506 N-Term(iTRAQ4plex) 1.391 3 1.5 1.082 3 10.9 1.351 3 4.4 1.248 3 5.2 1.507 3 1 1.429 3 7.1 1.145 3 0.6 38 3.52 0 2 813.96039 -4.1 63.76 1626.9135NWPESVYFFK PRG4 proteoglycan 4 isoform C precursor

[Homo sapiens]10216 NP_001121181 8 4 189181722 N-Term(iTRAQ4plex);

K10(iTRAQ4plex)65 5.52 0 3 928.01361 1.44 32.06 1855.01995

NWQWGGLTCDHYEEAK CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C9(Methylthio); K16(iTRAQ4plex)

0.877 1 1.004 1 0.82 1 0.817 1 0.937 1 0.933 1 1.142 1 53 2.99 0 2 944.51031 -1.56 58.02 1888.01335

NYCGLPGEYWLGNDK FGB fibrinogen beta chain isoform 1 preproprotein [Homo sapiens]

2244 NP_005132 4 2 70906435 N-Term(iTRAQ4plex); C3(Methylthio); K15(iTRAQ4plex)

0.577 1 0.923 1 0.515 1 0.557 1 0.595 1 0.645 1 1.157 1 47 3.08 0 2 657.89502 -6.39 37.07 1314.78276

NYNLVESLK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 58 1 73858566 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.163 71 19.9 0.986 69 26.7 1.03 71 22.8 1.057 69 15.3 1.209 71 27.6 1.242 69 27.1 1.139 71 21.8 114 10.21 0 3 1164.8436 -3.22 51.01 3492.53464

NYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLR

SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 3 1 4507171 N-Term(iTRAQ4plex) 1.308 31 10.4 0.887 31 12.4 1.216 31 14.9 1.297 31 15.7 1.374 31 14.5 1.473 31 10 1.143 31 11.8 114 6.32 0 3 1063.9735 0.23 26.86 2126.93974

NYQLYK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.237 97 15.2 0.84 97 16 1.074 97 24.5 1.263 97 16 1.186 97 15.7 1.499 97 17.7 1.133 97 10 110 8.51 0 3 850.76068 2.47 80.99 2550.26822

NYSPYYNTIDDLKDQIVDLTVGNNK

KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 7 2 55956899 N-Term(iTRAQ4plex); K13(iTRAQ4plex); K25(iTRAQ4plex)

1.316 44 12.6 0.934 42 15.6 1.22 43 18.2 1.287 42 22.3 1.331 44 13.4 1.45 42 15.3 1.085 43 20.7 107 7.71 0 3 1130.0244 0.52 27.72 2259.03862

NYVDWIMK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 14 1 41393602 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.17 18 13 0.972 18 13.4 1.055 18 11.6 1.097 18 14.4 1.219 18 13.5 1.28 18 14.8 1.134 18 5.5 106 5.96 0 2 805.90735 -2.9 25.02 1610.80901

NYVDWIMK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 7 1 41393602 N-Term(iTRAQ4plex); M7(Oxidation); K8(iTRAQ4plex)

1.386 21 13.4 0.869 21 11.3 1.2 21 19 1.391 21 14.5 1.35 21 17 1.517 21 12.9 1.111 21 19.3 105 7.99 0 3 1107.3992 2.75 65.95 3320.18296

PYQYPALTPEQK ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens]

226 NP_000025 1 1 4557305 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.186 4 12.1 1.091 4 17.8 1.156 4 23.7 1.128 4 2.5 1.294 4 19 1.186 4 3.4 1.084 4 7.1 102 6.72 1 3 942.00647 -1.84 19.85 1883.00058

QAAGSGHLLALGTPENPSWLSLHLQDQK

SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 4 2 7382460 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.303 121 15 0.931 121 20.5 1.174 121 17.7 1.25 121 19.1 1.324 121 20.3 1.39 121 16 1.157 121 14.6 99 8.83 0 3 1320.7023 -9.63 25.21 2640.43229

QADLDLARGDFAAAAGNLQTCLAVLGR

SREBF2 sterol regulatory element-binding protein 2 [Homo sapiens]

6721 NP_004590 1 1 27477113 N-Term(iTRAQ4plex); C21(Methylthio)

1.174 11 7.1 0.998 11 8.4 1.016 11 23.4 1.054 11 8.4 1.258 11 10.1 1.26 11 11.5 1.18 11 5.5 92 5.68 0 2 1019.9437 -3.33 28.07 2038.88413

QAEAVLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.008 15 25 0.981 15 19.8 0.974 15 31.7 0.967 15 19.9 1.089 15 22.4 1.102 15 14.4 1.162 15 9.7 89 6.53 0 3 687.32343 -0.32 42.9 2059.95572

QAEISASAPTSLR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 11 3 7382460 N-Term(iTRAQ4plex) 1.232 10 4.8 0.976 10 7.7 1.113 10 4.7 1.184 10 6.9 1.286 10 6.9 1.324 10 5.8 1.13 10 3.2 86 4.98 0 3 952.49957 1.45 53.75 1903.99187

QAELTVQVK PVR poliovirus receptor isoform gamma precursor [Homo sapiens]

5817 NP_001129241 4 4 209413730 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.228 7 11.6 0.879 6 8.6 1.051 7 9.2 1.258 6 12.7 1.138 7 14.9 1.352 6 16.8 1.14 7 17 84 8.86 0 3 988.80347 9.33 29.44 2964.33561

QAGLGNHLSGSER TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex) 1.156 15 19.1 1.037 15 8.2 1.116 15 15.8 1.115 15 16.2 1.326 15 17.9 1.317 15 15.6 1.147 15 4.3 79 4.11 0 2 714.92108 3.35 17.61 1428.83489

QAMGELSELSFHYLIMAK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.222 21 4.8 0.954 21 8 1.11 21 10.2 1.2 21 8 1.272 21 13 1.379 21 6.5 1.154 21 5.2 79 3.88 0 2 614.83466 -0.25 5.92 1228.66094

QAQCGQDFQCK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 8 1 4557389 N-Term(iTRAQ4plex); C4(Methylthio); C10(Methylthio); K11(iTRAQ4plex)

1.267 12 15.1 0.937 12 26.2 1.082 12 10.8 1.255 12 17.5 1.224 12 25.2 1.407 12 14.7 1.075 12 9.9 77 5.56 0 3 804.35504 -0.71 46.18 2411.05057

QATLTISSAR KIT mast/stem cell growth factor receptor Kit isoform 2 precursor [Homo sapiens]

3815 NP_001087241 2 2 148005039 N-Term(iTRAQ4plex) 1.245 3 7.1 1.003 3 2.5 1.186 3 6.9 1.182 3 14.6 1.314 3 0.7 1.304 3 1.8 1.214 3 3 71 4.83 1 3 459.90109 -0.08 30.06 1377.68872

QAVDTAVDGVFIR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 43 1 156119625 N-Term(iTRAQ4plex) 1.418 4 19.1 0.851 4 25.6 1.516 4 11.4 1.362 4 23.2 1.487 4 13.5 1.552 4 22.5 0.994 4 7.6 71 7.88 0 3 988.80347 9.33 29.44 2980.34708

QAVQELVSLYYEEAR NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 4 1 66346698 N-Term(iTRAQ4plex) 1.279 13 9.9 0.885 13 20.6 1.087 13 18.2 1.264 13 5.9 1.244 13 17.9 1.425 13 11.1 1.144 13 4.7 69 4.47 0 2 659.88953 -7.81 17.96 1318.78508

QCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQR

MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); C2(Methylthio); C6(Methylthio)

1.3 3 1.9 0.927 3 24.1 1.196 3 38.8 1.191 3 11.8 1.31 3 18.2 1.154 3 1.2 1.095 3 3.9 67 8.31 0 4 1043.1725 2.86 79.39 3127.49746

QCQDLGAFTESMVVFGCPN

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); C2(Methylthio); C17(Methylthio)

1.521 29 25.3 0.841 29 22.2 1.296 29 25.6 1.652 29 24.9 1.365 29 30.5 1.586 29 27.8 1.049 29 16.1 66 10.51 0 4 1043.1725 2.86 79.39 3143.499

QCTMFYSTSNIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 4 2 38016947 N-Term(iTRAQ4plex); C2(Methylthio); M4(Oxidation); K12(iTRAQ4plex)

0.939 1 0.879 1 0.811 1 0.923 1 0.953 1 1.085 1 1.175 1 65 4.53 0 2 1017.4519 -1.72 44.02 2033.89653

QCTMFYSTSNIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 N-Term(iTRAQ4plex); C2(Methylthio); K12(iTRAQ4plex)

1.123 19 7.9 0.99 19 21.1 1.053 19 13.7 1.005 19 10.5 1.217 19 15.8 1.186 19 9 1.151 19 10 62 4.81 1 3 1170.5557 2.07 27.25 2340.1005

QCVAEGSPQR NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 2 1 115298674 N-Term(iTRAQ4plex); C2(Methylthio)

2.323 5 4.1 0.893 5 7.8 2.099 5 10.6 2.313 5 5.5 2.36 5 8.1 2.557 5 2.9 1.123 5 2.3 58 3.47 0 2 1017.4519 -1.72 44.02 2049.91069

Page 32: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

QCVPHDQCACGVLTSEK PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 1 2 4506121 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); C10(Methylthio); K17(iTRAQ4plex)

1.125 22 4.5 1.012 22 13.2 1.032 22 5.2 1.079 22 8.7 1.179 22 10.2 1.223 22 7.3 1.141 22 6.4 58 5.61 0 2 755.8504 0.13 37.13 1510.68828

QCVPTEPCEDAEDDCGNDFQCSTGR

C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 11 1 4502511 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); C15(Methylthio); C21(Methylthio)

1.107 17 15.6 0.924 17 4.1 1.036 17 9.3 1.07 17 14.3 1.085 17 19.3 1.222 17 15.5 1.173 17 10.7 58 7.8 0 4 1153.0835 -0.29 34.01 2305.16933

QCVYDLCAQK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

5 1 154146262 N-Term(iTRAQ4plex); C2(Methylthio); C7(Methylthio); K10(iTRAQ4plex)

1.246 55 7.7 0.932 55 6.3 1.151 55 9.2 1.221 55 6.7 1.27 55 8.9 1.357 55 6.9 1.119 55 5.7 55 3.94 0 3 461.25262 1.01 66.87 1381.74332

QDACQGDSGGVFAVR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

33 1 66347875 N-Term(iTRAQ4plex); C4(Methylthio)

1.271 1 0.959 1 1.159 1 1.208 1 1.331 1 1.388 1 1.149 1 54 3.64 0 2 584.82239 1.87 12.24 1168.6375

QDGHLWCSTTSNYEQDQK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

12 6 47132549;16933542

N-Term(iTRAQ4plex); C7(Methylthio); K18(iTRAQ4plex)

1.046 8 6.7 1.048 8 13.9 0.963 8 13.3 0.981 8 5.9 1.142 8 8 1.091 8 9.7 1.124 8 8.6 53 7.79 0 4 1484.7994 0.78 45.89 2968.59926

QDGSVDFFR FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 8 2 27754776 N-Term(iTRAQ4plex) 1.105 37 9.4 0.95 37 6.7 1.024 37 8.9 1.046 37 7 1.178 37 8 1.193 37 8.4 1.141 37 3.1 51 3.4 0 2 645.31696 0.42 55.73 1289.6259

QDLGSPEGIAVDHLGR NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 4 1 115298674 N-Term(iTRAQ4plex) 1.13 20 11.5 0.931 20 28.6 1.092 20 17.8 1.098 20 21.1 1.159 20 20 1.261 20 17.9 1.146 20 14.5 50 8.16 0 3 1115.1796 7.19 53.74 3343.52414

QDPPSVVVTSHQAPGEK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 28 1 4502337 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.222 7 17 0.896 7 26.4 1.175 7 18.5 1.276 7 5.3 1.182 7 28.8 1.38 7 9.3 1.133 7 6.8 50 7.22 1 3 856.3913 2.31 24.34 2567.15934

QDSISSK AFM afamin precursor [Homo sapiens] 173 NP_001124 5 1 4501987 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.153 18 3.8 0.931 18 7.5 1.055 18 9.3 1.121 18 5.2 1.193 18 8.5 1.267 18 3.6 1.127 18 2.9 49 3.27 0 3 407.86734 -0.2 37.85 1221.58806

QDSLSSQNQLGVLPLSWDIPELVNMGQWK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 18 1 115298678 N-Term(iTRAQ4plex); K29(iTRAQ4plex)

1.706 9 16.1 0.902 9 17.9 1.515 9 21.2 1.636 9 16 1.777 9 14.5 1.896 9 21.3 1.177 9 7.6 49 5.1 0 3 755.8504 0.13 37.13 1526.68183

QDSLSSQNQLGVLPLSWDIPELVNMGQWK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); M25(Oxidation); K29(iTRAQ4plex)

1.788 9 4.7 0.966 9 7.8 1.612 9 8.3 1.759 9 7.3 1.831 9 9.1 1.948 9 8.2 1.115 9 5.1 48 0 2 461.25262 1.01 66.87 1397.73674

QDSQLQK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 11 1 4502337 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.347 36 9.2 1.01 36 8.4 1.265 36 10.2 1.279 36 8.6 1.4 36 9.6 1.409 36 9.6 1.115 36 4.2 47 3.17 0 2 569.33923 -4.07 20.79 1137.67375

QDWVDSGCPEESK PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex); C8(Methylthio); K13(iTRAQ4plex)

1.149 15 17.5 1.098 15 5.8 1.109 15 17.8 1.081 15 19.4 1.24 15 19.5 1.217 15 19.1 1.123 15 4.4 46 3.02 0 2 588.30371 -3.52 23.38 1175.60808

QEAIYEMSRGEQDLIEDLK NET1 neuroepithelial cell-transforming gene 1 protein isoform 2 [Homo sapiens]

10276 NP_005854 1 2 19923327 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.181 35 6.6 0.946 35 6.3 1.068 35 9.9 1.125 35 5.6 1.192 35 8.8 1.262 35 5.7 1.122 35 4.3 45 4.72 0 2 748.76758 -0.28 60.25 1496.52788

QEALELMNQNLDIYEQQVMTAAQK

BTD biotinidase precursor [Homo sapiens]

686 NP_000051 6 1 4557373 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.262 3 4.1 1.023 3 5.2 1.22 3 2.6 1.214 3 0.7 1.382 3 13.6 1.302 3 11.1 1.133 3 16.3 45 3.74 0 2 721.88531 8.64 16.08 1442.76335

QEATTVSCFR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 4 1 205277383 N-Term(iTRAQ4plex); C8(Methylthio)

0.99 11 7.3 1.091 11 9.6 0.957 11 4.8 0.917 11 12.7 1.067 11 7.7 0.989 11 10.5 1.117 11 1.7 44 3.25 0 2 635.30475 -14.81 18.63 1269.62627

QECSIPVCGQDQVTVAMTPR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 4 1 4503635 N-Term(iTRAQ4plex); C3(Methylthio); C8(Methylthio)

1.086 7 5 0.993 7 3.8 1.002 7 12.3 1.089 7 8.2 1.092 7 8.5 1.23 7 12 1.107 7 2.5 42 3.51 0 2 608.76062 -5.57 17.05 1216.51824

QEDACQGDSGGPHVTR F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 2 1 4503625 N-Term(iTRAQ4plex); C5(Methylthio)

1.083 10 11.9 0.908 10 20.5 0.919 10 21.5 0.947 10 19.1 1.177 10 11.2 1.27 10 18.3 1.201 10 13.4 38 7.62 1 3 1205.9083 3.67 45.51 3615.71189

QEDDLANINQWVK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 25 2 115583663 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.311 2 7.8 0.848 2 15.9 1.15 2 0.3 1.356 2 16.2 1.277 2 0.8 1.506 2 16.7 1.11 2 0.5 31 2.83 0 2 470.73401 0.26 7.22 940.46074

QEEQTTCTTEGWSPEPR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 7 1 110611237 N-Term(iTRAQ4plex); C7(Methylthio)

1.271 1 1.069 1 1.248 1 1.168 1 1.381 1 1.293 1 1.107 1 28 0 2 521.77216 -6.52 18.74 1042.53703

QEIECQNQEYSLLLSIK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex); C5(Methylthio); K17(iTRAQ4plex)

0.981 4 20.5 1.002 4 6.5 0.897 4 17.9 0.993 4 14.4 1.038 4 36.2 1.032 4 19.1 1.123 4 41.2 7.43 1 4 839.70447 -5.13 40.08 3355.79604

QEINSHVEMQTK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 12 1 205277441 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.253 4 4.1 0.959 4 12.5 1.12 4 14.7 1.216 4 7 1.287 4 8.6 1.361 4 9.2 1.147 4 3.9 5.08 0 3 647.65717 -1.66 29.87 1940.95694

QEINSHVEMQTK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 4 1 205277441 N-Term(iTRAQ4plex); M9(Oxidation); K12(iTRAQ4plex)

0.72 2 49.2 0.798 2 25.1 0.862 2 12.5 1.081 2 12.3 0.294 2 477.9 0.369 2 308.1 0.341 2 381.2 5.01 0 4 964.45129 -2.01 48.41 3854.78335

QELSEAEQATR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 5 1 115298678 N-Term(iTRAQ4plex) 1.634 1 0.934 1 1.547 1 1.656 1 1.613 1 1.727 1 1.043 1 4.7 1 4 1032.5068 4.21 53.82 4127.00551

QEPGENSEILPTLK GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 15 1 6006001 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.189 2 13.3 1.039 2 1.2 1.181 2 9.7 1.137 2 10.9 1.243 2 15.6 1.196 2 16.8 1.052 2 5.8 4.3 1 3 699.69775 8.31 24.84 2097.07871

QETLDGHMVVR NCAM1 neural cell adhesion molecule 1 isoform 2 precursor [Homo sapiens]

4684 NP_851996 2 1 115529482 N-Term(iTRAQ4plex) 1.196 1 1.029 1 1.148 1 1.116 1 1.279 1 1.243 1 1.113 1 3.21 0 2 778.3609 -0.59 32.44 1555.71453

QEYDESGPSIVHR ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 2 6 4501885 N-Term(iTRAQ4plex) 1.136 64 13.2 0.94 64 13.9 1.012 64 12.5 1.091 64 20.2 1.211 64 12.6 1.267 64 19 1.137 64 8.9 94 6.61 1 3 671.67743 -10.04 26.26 2013.03696

QEYEQLIAK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 4 2 55956899 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.298 8 13.1 0.96 8 13.2 1.198 8 16.3 1.346 8 19.7 1.351 8 20.5 1.525 8 16.9 1.082 8 5.9 79 5.61 0 2 842.41388 0.62 48.11 1683.81792

QFGPYCGHGFPGPLNIETK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 14 1 41393602 N-Term(iTRAQ4plex); C6(Methylthio); K19(iTRAQ4plex)

1.038 12 15.4 0.966 12 8.3 0.958 12 15.3 1.053 12 16.4 0.982 12 6.5 1.101 12 15.1 1.09 12 9 78 5.89 0 2 923.99579 4.6 22.89 1846.95891

QFPILLDFK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 86 1 73858566 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.076 12 15.9 1.002 12 11.8 1.043 12 23.3 1.034 12 8.8 1.107 12 12.5 1.136 12 5.9 1.109 12 2.8 69 4.53 0 2 694.92346 3.22 26.98 1388.83171

QFQADFTSLSDQEPLHVAQALQK

SERPINE1 plasminogen activator inhibitor 1 isoform 2 precursor [Homo sapiens]

5054 NP_001158885 2 2 259155306 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.149 7 4.8 1.131 7 15.7 1.051 7 15.7 1.059 7 9.6 1.342 7 10.6 1.175 7 3.7 1.092 7 6.6 46 1 2 597.31586 -0.68 9.64 1193.62444

QFSFPLSSEPFQGSYK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 14 1 66932947 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.094 8 4.6 1.013 8 5.9 1.043 8 6.3 1.038 8 3.3 1.165 8 6.2 1.195 8 5.9 1.123 8 3.4 43 3.12 0 2 595.2937 -2.11 36.57 1189.58379

QFSSSYLSR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex) 1.972 1 0.941 1 1.692 1 1.798 1 2.136 1 2.27 1 1.262 1 39 0 2 461.21817 0.92 10.05 921.42906

QFTSSTSYNR FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 6 2 4503689 N-Term(iTRAQ4plex) 1.121 5 2.3 0.84 5 2.7 0.933 5 4.6 1.145 5 11.1 1.117 5 2.1 1.334 5 3.9 1.178 5 8.8 34 3.69 0 3 376.89294 2.42 10.53 1128.66428

QFVTATDVVR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 3 1 167614506 N-Term(iTRAQ4plex) 0.746 4 16.1 0.866 4 5.7 0.706 4 18.9 0.681 4 33.3 0.818 4 19.5 0.78 4 32.2 1.163 4 2.2 27 0 2 489.21832 -6.1 21.79 977.42937QGALELIK C3 complement C3 precursor [Homo

sapiens]718 NP_000055 9 1 115298678 N-Term(iTRAQ4plex);

K8(iTRAQ4plex)0.162 1 0.69 1 0.118 1 0.171 1 0.155 1 0.225 1 1.318 1 23 0 2 380.26675 7 33.67 759.52623

QGASGIAGLAGPGGGSGAAAGAGGRALELAEAR

TRNP1 TMF-regulated nuclear protein 1 [Homo sapiens]

388610 NP_001013664 XP_371238

3 1 61966741 N-Term(iTRAQ4plex) 1.079 2 0.9 0.776 2 25.5 0.912 2 17.6 1.175 2 7.7 1.01 2 6.9 1.301 2 18.4 1.107 2 10.6 99 9.4 0 3 793.05927 -0.9 28.82 2377.16324

QGDVECQR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 7 1 169636415 N-Term(iTRAQ4plex); C6(Methylthio)

1.002 3 7.1 0.72 3 4.6 0.762 3 5.9 1.021 3 0.5 0.991 3 20 1.237 3 0.6 1.211 3 10.7 95 9.19 0 3 978.14594 -0.78 57.88 2932.42325

QGETLNFLEIGYSR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 8 3 221316614 N-Term(iTRAQ4plex) 0.95 3 3 0.911 3 10 0.962 3 30.4 1.129 3 87.1 0.915 3 20.7 1.004 3 7.5 0.828 3 117.3 95 9.55 0 3 1288.6786 5.36 62.74 3864.02121

QGFFPDSVNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 28 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.677 3 10.8 0.907 3 2.4 0.602 3 71.9 0.652 3 49.4 0.61 3 0.1 0.672 3 2.5 1.013 3 71.9 72 8.25 0 4 1160.8628 0.97 78.59 3480.57241

QGHNSVFLIK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 2 1 11321561 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.029 4 18 1.027 4 14.9 0.972 4 45.6 1.039 4 16.1 1.101 4 14.7 1.096 4 3.6 1.056 4 19.9 60 3.51 0 2 795.85376 0.12 10.71 1590.70024

QGIPFFAQVLLVDGK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 6 1 162809334 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.907 6 11 0.942 6 28.7 0.765 6 4.5 0.894 6 22.3 0.951 6 17 1.01 6 10.7 1.167 6 7.2 60 5.69 0 2 871.95227 -11.45 26.67 1742.90618

QGIPFFGQVR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 5 1 66932947 N-Term(iTRAQ4plex) 1.725 1 0.977 1 1.603 1 1.64 1 1.807 1 1.849 1 1.127 1 57 4.01 0 2 866.47675 -3.35 42.45 1731.94621

QGLLPVLESFK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 4 1 4557321 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.144 8 8.1 0.99 8 13.4 1.058 8 12.8 1.09 8 5.1 1.192 8 13.7 1.199 8 9.2 1.141 8 4.5 54 4.23 0 2 635.39252 -2.51 41.63 1269.77324

QGPVNLLSDPEQGVEVTGQYER

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

37 2 31542984;262050538

N-Term(iTRAQ4plex) 1.155 4 6.6 1.056 4 10.7 1.127 4 12.5 1.08 4 4 1.246 4 14.6 1.211 4 3.2 1.116 4 1.4 52 3.72 0 2 660.37531 -1.24 41.26 1319.74138

QGQGQSEPGEYEQR MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 2 1 71274107 N-Term(iTRAQ4plex) 1.155 2 1.6 0.903 2 9.7 1.023 2 4.2 1.133 2 5.4 1.176 2 1.9 1.303 2 7.8 1.15 2 2.3 46 5.41 1 3 944.52765 -2.71 32.77 1888.04953

QGSFQGGFR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

5 6 178557739;67190748

N-Term(iTRAQ4plex) 1.07 1 1.007 1 1.008 1 1.001 1 1.139 1 1.132 1 1.131 1 41 4.28 0 3 485.27057 10.34 28.85 1453.79715

QGYDLSPLTPLSELSVQCNR

F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 4 1 110611237 N-Term(iTRAQ4plex); C18(Methylthio)

0.982 1 0.827 1 0.899 1 1.088 1 0.895 1 1.083 1 0.996 1 40 7.05 1 5 641.73248 3.35 53.46 3204.63331

QGYFVEAQPK APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 6 1 4502133 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.037 1 1.084 1 0.996 1 0.919 1 1.165 1 1.075 1 1.169 1 2.79 0 2 505.27225 -6.23 17.28 1009.53722

QGYQLIEGNQVLHSFTAVCQDDGTWHR

C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

14 1 66347875 N-Term(iTRAQ4plex); C19(Methylthio)

1.209 4 7.3 1.091 4 14.1 1.068 4 19 1.011 4 8.3 1.304 4 27.1 1.317 4 19.7 1.302 4 7.4 104 9.38 0 3 953.1911 -1.77 50.75 2857.55875

QHIEAIDVR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex) 1.154 2 0.7 0.902 2 7.7 1.028 2 2.7 1.139 2 5 1.169 2 3.2 1.296 2 4.5 1.137 2 0.5 76 6.01 0 2 939.45856 -1.12 31.5 1877.90984

QHLGDVLNFLPL C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 20 3 14550407 N-Term(iTRAQ4plex) 1.189 5 3.4 0.922 5 9 1.072 5 9.8 1.18 5 8 1.216 5 6.2 1.357 5 4.9 1.128 5 10.7 63 4.78 0 2 677.88196 -2.48 28.09 1354.75688

QHQLGVWPLLPGSFK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 1 1 105990535 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.014 1 0.689 1 0.752 1 1.091 1 0.961 1 1.394 1 1.279 1 48 3.67 0 2 655.87671 -7.41 17.92 1310.74614

QHVVSVEEALLATGQWK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 6 1 40317626 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.145 1 0.792 1 1.052 1 1.328 1 1 1 1.262 1 0.951 1 43 4.78 1 3 618.68591 -2.41 31.06 1854.04319

QHVVYGPWNLPQSSYSHLTR

ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 6 3 221316614 N-Term(iTRAQ4plex) 0.905 1 0.867 1 0.774 1 0.892 1 0.915 1 1.055 1 1.182 1 43 3.85 0 2 849.47711 0.24 39.24 1697.94695

QIDDIDVR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 15 1 105990532 N-Term(iTRAQ4plex) 1.301 2 8.2 0.962 2 27.2 1.202 2 21.9 1.25 2 5 1.36 2 21.1 1.414 2 5.9 1.131 2 0.8 42 2.85 0 2 566.32489 -1.41 35.89 1131.64446

QILVDEAGMATEPETLIPLVQFPQAEK

HELZ2 peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein isoform 2 [Homo sapiens]

85441 NP_208384 XP_114156

1 2 156105695 N-Term(iTRAQ4plex); M9(Oxidation); K27(iTRAQ4plex)

1.724 3 3.3 0.919 3 6.4 1.517 3 7.5 1.724 3 1.1 1.724 3 3.9 1.945 3 1 1.136 3 2.2 41 5.33 0 3 939.45856 -1.12 31.5 1893.91697

QINDYVEK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 2 1 189163538 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.136 2 6.4 1.044 2 1.4 1.082 2 7.5 1.036 2 6.1 1.24 2 6.8 1.187 2 5.4 1.145 2 0.7 38 2.94 0 2 502.29382 -0.2 26.22 1003.5764

QINSYVK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 1 1 73858564 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.304 1 1.248 1 1.38 1 1.106 1 1.551 1 1.243 1 1.124 1 5.07 0 3 748.65973 -0.28 29.65 2243.96463

QIQVFEDEPAR IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 2 3 19882209 N-Term(iTRAQ4plex) 1.109 2 21.1 0.928 2 19.4 0.99 2 30.8 1.067 2 10.9 1.153 2 30.9 1.242 2 11 1.164 2 0.1 3.51 0 2 585.30042 0.64 48.73 1169.59355

QISNLQQSISDAEQR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 6 2 119395750 N-Term(iTRAQ4plex) 1.316 1 0.769 1 1.157 1 1.506 1 1.17 1 1.522 1 1.011 1 4.3 0 3 838.45135 6.2 39.55 2513.33951

QKDVDKEFYLFPTVFDENESLLLEDNIR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 8 1 4557485 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K6(iTRAQ4plex)

1.785 1 0.932 1 1.645 1 1.764 1 1.803 1 1.934 1 1.096 1 2.79 0 2 580.82263 -1.07 18.66 1160.63799

QKPDGVFQEDAPVIHQEMIGGLR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 77 1 115298678 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.568 1 0.933 1 1.366 1 1.464 1 1.664 1 1.784 1 1.218 1 2.75 1 2 981.49121 -13.14 37.38 1961.97515

QKPDGVFQEDAPVIHQEMIGGLR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 12 1 115298678 N-Term(iTRAQ4plex); K2(iTRAQ4plex); M18(Oxidation)

1.562 4 15.9 0.863 4 21 1.501 4 18.3 1.665 4 11.7 1.322 4 16.3 1.638 4 13.8 0.971 4 22.4 76 10.75 0 3 1086.2251 1.79 58.11 3256.66074

QKWEAEPVYVQR AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 4 1 4502337 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.033 1 1.163 1 1.064 1 0.915 1 1.17 1 1.006 1 1.099 1 67 6.16 0 3 520.2937 -10.68 25.01 1558.86655

QLAEEYLYR MMP9 matrix metalloproteinase-9 preproprotein [Homo sapiens]

4318 NP_004985 2 1 74272287 N-Term(iTRAQ4plex) 1.091 2 8.2 0.957 2 6.2 0.983 2 6.8 1.026 2 13 1.154 2 3.8 1.205 2 10 1.174 2 3 51 4.62 0 3 799.43799 0.74 35.79 1597.86087

QLCSFEIYEVPWEDR CST4 cystatin-S precursor [Homo sapiens]

1472 NP_001890 2 1 4503109 N-Term(iTRAQ4plex); C3(Methylthio)

1.956 1 0.748 1 1.756 1 2.347 1 1.664 1 2.224 1 0.948 1 3.57 1 3 786.81067 13.47 57.85 2358.41745

QLENLVQELSQSNMMLYK HAUS3 HAUS augmin-like complex subunit 3 [Homo sapiens]

79441 NP_078787 1 1 56711324 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.02 2 14 0.883 2 2.8 0.95 2 25.2 1.076 2 22.3 0.968 2 5.9 1.096 2 3.1 1.018 2 19.1 55 8.07 0 3 1066.5402 2.45 46.64 3197.60593

QLEWGLER C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 6 1 169636415 N-Term(iTRAQ4plex) 1.103 1 1.024 1 1.029 1 1.005 1 1.204 1 1.176 1 1.17 1 38 5.72 0 3 921.44049 5.29 49.25 2762.30692

QLGAGSIEECAAK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 35 2 4505881 N-Term(iTRAQ4plex); C10(Methylthio); K13(iTRAQ4plex)

1.291 1 1.034 1 1.236 1 1.195 1 1.391 1 1.345 1 1.125 1 4.32 0 3 592.65515 -2.95 25.92 1775.9509

QLGCPTAVTAIGR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C4(Methylthio)

1.284 1 0.861 1 1.149 1 1.335 1 1.239 1 1.44 1 1.079 1 68 4.97 0 2 789.36743 -7.76 29.84 1577.72759

QLGLPGPPDVPDHAAYHPFR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

17 2 31542984;262050538

N-Term(iTRAQ4plex) 1.352 1 0.861 1 1.159 1 1.347 1 1.357 1 1.576 1 1.171 1 35 4.63 0 3 616.98761 -1.69 45.92 1848.94828

QLLLTADDR ALDOA fructose-bisphosphate aldolase A isoform 1 [Homo sapiens]

226 NP_000025 2 3 4557305 N-Term(iTRAQ4plex) 1.384 3 5.2 1.01 3 1.6 1.257 3 6.9 1.355 3 4.5 1.444 3 7.5 1.556 3 4 1.149 3 0.1 89 6.95 0 3 1016.0228 3.69 40.27 2031.02982

QLNEINYEDHK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 4 1 67782358 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.292 1 0.915 1 1.15 1 1.257 1 1.325 1 1.448 1 1.152 1 73 6.96 0 3 699.05237 -0.05 48.5 2095.14255

QLPGGQNPVSYVYLEVVSK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 30 2 38016947 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.7 1 0.934 1 0.642 1 0.688 1 0.712 1 0.763 1 1.11 1 58 3.79 0 2 759.3642 0.13 34.71 1517.72112

QLTPYAQR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 1 1 71773110 N-Term(iTRAQ4plex) 0.988 6 11.9 0.973 6 2.5 0.876 6 10 0.941 6 17.8 1.038 6 8.6 1.078 6 16.1 1.182 6 9.6 93 5.36 0 3 1042.0223 0.61 55.75 2083.03946

QLTSGPNQEQVSPLTLLK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 8 2 115583663 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.008 3 2.1 1.041 3 2.7 0.957 3 3.7 0.913 3 7.2 1.16 3 9 1.054 3 0.2 1.153 3 7.2 88 4.68 0 2 840.8728 -6.24 37.08 1680.73833

QLVCPVTR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

1 1 256217721 N-Term(iTRAQ4plex); C4(Methylthio)

0.949 3 9.4 1.085 3 4.9 0.865 3 11 0.831 3 20.8 1.032 3 7 0.964 3 20.9 1.161 3 0.2 77 4.74 0 2 782.43317 -1.37 22.99 1563.85906

QLVEIEK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 7 3 4826762 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.077 2 4.3 1.075 2 7.6 1.054 2 10.3 0.98 2 2.7 1.181 2 6.3 1.099 2 1.3 1.121 2 3.9 77 4.93 0 2 960.48578 0.23 80.51 1919.96428

QLVHHFEIDVDIFEPQGISK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 32 2 156119625 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

0.582 1 0.642 1 0.276 1 0.43 1 0.679 1 1.059 1 2.463 1 67 4.63 0 3 1214.5061 5.35 72.27 3641.50376

QLYGDTGVLGR C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 13 1 166197660 N-Term(iTRAQ4plex) 0.745 4 9.6 0.888 4 9.3 0.707 4 9.2 0.748 4 5.2 0.767 4 9.4 0.799 4 13.5 1.033 4 10.4 47 4.52 0 3 520.2594 -1.58 27.32 1558.76364

QLYNVEATSYALLALLQLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 75 1 115298678 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.005 3 3.9 0.884 3 12.2 0.925 3 0.7 1.051 3 4.5 0.994 3 7.5 1.208 3 3.7 1.115 3 5.5 42 3.47 0 2 625.86554 1.01 37.3 1250.72502

QMEQTYWQANPFR COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 1 1 40217843 N-Term(iTRAQ4plex) 0.954 3 18.2 0.847 3 4.6 0.902 3 4.5 0.838 3 46.7 1.034 3 6.4 1.004 3 34.5 1.113 3 10.9 41 4.11 0 3 498.27002 4.04 29.08 1492.79551

QMIFDMLK CNGB1 cyclic nucleotide-gated cation channel beta-1 isoform a [Homo sapiens]

1258 NP_001288 1 1 114205399 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.328 2 4.5 0.98 2 0.2 1.203 2 7.4 1.227 2 7.7 1.426 2 1.7 1.455 2 2 1.186 2 5.7 39 4.61 0 3 520.2594 -1.58 27.32 1574.76262

QMIKEAFAGDDVIRDFLK UTP14A U3 small nucleolar RNA-associated protein 14 homolog A isoform 2 [Homo sapiens]

10813 NP_001159693 1 3 261278315 N-Term(iTRAQ4plex); M2(Oxidation); K4(iTRAQ4plex); K18(iTRAQ4plex)

0.777 2 16 0.781 2 56.1 0.647 2 56.6 0.829 2 0.4 0.753 2 27.4 0.964 2 25.8 1.164 2 26.2 37 7.88 0 4 1061.7839 4.83 59.59 4244.11391

QNADQCCPEYECVCDPVSCDLPPVPHCER

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex); C6(Methylthio); C7(Methylthio); C12(Methylthio); C14(Methylthio); C19(Methylthio); C27(Methylthio)

0.836 1 1.137 1 0.847 1 0.745 1 0.94 1 0.827 1 1.11 1 4.34 1 4 642.34607 0.82 42.8 2566.36245

QNGAALTSASILAQQVWGTLVLLQR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 16 1 156616294 N-Term(iTRAQ4plex) 1.117 1 1 1 1.006 1 1.005 1 1.229 1 1.228 1 1.222 1 3.84 0 3 575.60724 3.28 31.88 1724.80716

QNLEPLFEQYINNLR KRT5;KRT6A

keratin, type II cytoskeletal 5 [Homo sapiens];keratin, type II cytoskeletal 6A [Homo sapiens]

3852;3853 NP_000415;NP_005545 NP_490596

4 4 119395754;5031839

N-Term(iTRAQ4plex) 1.426 1 0.924 1 1.388 1 1.502 1 1.355 1 1.467 1 0.977 1 3.57 0 3 694.36145 -16.4 60.44 2081.0698

QNLEPLFEQYINNLRR KRT5;KRT6A

keratin, type II cytoskeletal 5 [Homo sapiens];keratin, type II cytoskeletal 6A [Homo sapiens]

3852;3853 NP_000415;NP_005545 NP_490596

1 4 119395754;5031839

N-Term(iTRAQ4plex) 1.74 1 1.017 1 1.747 1 1.718 1 1.762 1 1.733 1 1.008 1 3.67 1 3 800.77539 9.04 80.06 2400.31162

QNLFMGENQFNVPK VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 4 1 223633991 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.749 1 0.973 1 0.685 1 0.703 1 0.793 1 0.815 1 1.159 1 64 3.97 0 2 941.95825 -6.5 45.06 1882.90923

QPFVQGLALYTPVVLPR AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 22 1 4557287 N-Term(iTRAQ4plex) 0.748 1 0.873 1 0.631 1 0.723 1 0.769 1 0.882 1 1.22 1 3.95 0 2 680.39716 -2.14 45.64 1359.78703

QPNCDDPETEEAALVAIDYINQNLPWGYK

AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 174 1 156523970 N-Term(iTRAQ4plex); C4(Methylthio); K29(iTRAQ4plex)

1.488 2 30 0.942 2 60.2 1.516 2 6.9 1.61 2 51.7 1.418 2 12.4 1.505 2 76.6 0.935 2 19.5 86 5.37 0 3 1077.5452 0.45 79.07 3230.62094

QPSSAFAAFVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 54 1 115298678 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.949 2 3.9 0.861 2 1.4 0.803 2 5.6 0.933 2 7 0.964 2 1.4 1.119 2 2.8 1.2 2 4.2 83 4.52 0 2 802.50494 0.01 71.3 1604.00261

QPVPGQQMTLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 3 1 115298678 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.023 1 0.772 1 0.819 1 1.061 1 0.992 1 1.286 1 1.212 1 69 3.75 0 2 895.01123 -3.06 59.63 1789.01518

QPYSYDFPEDVAPALGTSFSHMLGATNPTQK

C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 20 3 14550407 N-Term(iTRAQ4plex); K31(iTRAQ4plex)

1.811 1 1.214 1 0.61 1 77.017 1 0.503 1 59 4.83 0 3 945.51459 0.82 80.83 2834.52921

QPYSYDFPEDVAPALGTSFSHMLGATNPTQK

C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 5 3 14550407 N-Term(iTRAQ4plex); M22(Oxidation); K31(iTRAQ4plex)

1.099 1 1.046 1 1.053 1 1.007 1 1.195 1 1.143 1 1.135 1 58 4.66 0 2 979.92969 -4.58 35.48 1958.8521

QQNAQGGFSSTQDTVVALHALSK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 8 1 66932947 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.583 1 0.709 1 1.226 1 1.73 1 1.479 1 2.087 1 1.207 1 45 5.27 0 3 728.05896 -1.65 54.38 2182.16233

QQQDYWLIDVR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 2 1 157266300 N-Term(iTRAQ4plex) 1.206 1 0.884 1 1.05 1 1.188 1 1.223 1 1.383 1 1.164 1 38 3.95 0 3 490.59094 0.34 12.02 1469.75827

QQRNRGFGQSNSLPTAGSVGGGMGR

SAMD4A protein Smaug homolog 1 isoform 3 [Homo sapiens]

23034 NP_001155049 1 3 239582751 N-Term(iTRAQ4plex); M23(Oxidation)

1.194 1 0.939 1 1.079 1 1.149 1 1.236 1 1.317 1 1.146 1 36 2.86 0 2 581.3446 -0.93 12.47 1161.68193

QQTEEMWEVLKPK CTBS di-N-acetylchitobiase precursor [Homo sapiens]

1486 NP_004379 2 1 4758092 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K13(iTRAQ4plex)

1.028 1 1.051 1 1.026 1 0.976 1 1.083 1 1.03 1 1.055 1 36 2.88 0 2 564.33057 -0.26 35.9 1127.65386

QQTEWQSGQR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 6 1 4557325 N-Term(iTRAQ4plex) 1.08 1 0.919 1 0.996 1 1.083 1 1.076 1 1.171 1 1.081 1 34 5.31 0 2 922.96814 -0.54 47.53 1844.929

QQTHMLDVMQDHFSR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 8 1 355594753 N-Term(iTRAQ4plex) 0.968 1 0.958 1 0.863 1 0.901 1 1.032 1 1.077 1 1.195 1 33 3.82 0 2 624.31458 0.61 44.89 1247.62187

QQTHMLDVMQDHFSR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 3 1 355594753 N-Term(iTRAQ4plex); M5(Oxidation); M9(Oxidation)

1.068 2 9.6 0.899 2 5.9 0.973 2 12 1.081 2 17.9 1.055 2 2.1 1.172 2 8 1.084 2 9.8 81 4.35 0 2 689.36517 -0.94 24.43 1377.72307

QRNAAALTTLLDLGASPDYKDSR

SHANK3 SH3 and multiple ankyrin repeat domains protein 3 [Homo sapiens]

85358 NP_277052 1 1 380748963 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.664 5 5.1 0.881 5 28.8 1.053 5 13.4 1.446 5 35.7 1.58 5 23.2 1.758 5 36.8 1.207 5 22.9 81 8.99 0 3 987.51453 1.56 67.66 2960.525

QRPEVFSDNMFCVGDETQR

C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 10 1 289547636 N-Term(iTRAQ4plex); C12(Methylthio)

0.956 2 1.1 0.98 2 7.6 0.88 2 1.4 0.897 2 6.2 1.013 2 3.8 1.034 2 3.8 1.152 2 2.5 71 7.04 0 3 699.65717 2.67 56.42 2096.95694

QRPEVFSDNMFCVGDETQR

C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 2 1 289547636 N-Term(iTRAQ4plex); M10(Oxidation); C12(Methylthio)

1.174 1 0.992 1 1.06 1 1.069 1 1.278 1 1.288 1 1.205 1 46 3.53 0 2 740.36346 -0.59 51.8 1479.71965

QRPPDLDTSSNAVDLLFFTDESGDSR

C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

53 1 66347875 N-Term(iTRAQ4plex) 1.122 2 16.5 0.914 2 22.2 1.024 2 28.2 1.12 2 5.8 1.13 2 26.6 1.236 2 4.3 1.104 2 1.5 76 5.38 0 2 904.96521 -2.09 19.74 1808.92314

QSEDSTFYLGER CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 94 1 4557485 N-Term(iTRAQ4plex) 0.945 1 1.273 1 0.923 1 0.725 1 1.226 1 0.963 1 1.328 1 55 5.02 0 3 895.12317 0.47 71.14 2683.35495

QSFDLSVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.784 1 0.881 1 0.683 1 0.775 1 0.792 1 0.899 1 1.159 1 31 0 2 531.78851 -2 36.56 1062.56975

Page 33: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

QSGLYFIKPLK FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); K8(iTRAQ4plex); K11(iTRAQ4plex)

1.902 1 0.874 1 1.862 1 2.132 1 1.702 1 1.948 1 0.914 1 3.44 1 3 623.7027 -5.55 72.53 1869.09354

QSLEASLAETEGR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

13 2 195972866 N-Term(iTRAQ4plex) 0.364 1 0.962 1 0.323 1 0.335 1 0.391 1 0.407 1 1.213 1 52 4.38 0 2 694.38104 -0.13 31.06 1387.75481

QSMTLSSEVQIPDFDVDLGTILR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 24 1 105990532 N-Term(iTRAQ4plex); M3(Oxidation)

1.29 1 0.915 1 1.16 1 1.268 1 1.311 1 1.432 1 1.13 1 2.97 0 2 879.93848 -2.43 21.03 1758.86968

QSPDYK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 2 1 169636415 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.671 1 1.064 1 1.61 1 1.513 1 1.839 1 1.728 1 1.142 1 59 3.29 0 2 652.33313 -14.03 21.17 1303.65898

QSSSYSFFK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 9 1 4502503 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.215 1 0.815 1 1.015 1 1.246 1 1.19 1 1.461 1 1.172 1 55 3.9 0 2 829.44183 -2.95 22.4 1657.87639

QSTLSYQEPLRT F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 2 1 110611237 N-Term(iTRAQ4plex) 1.007 2 7.2 0.96 2 1.4 0.943 2 7.1 0.983 2 8.6 1.029 2 5.9 1.072 2 7.3 1.091 2 1.3 45 4.95 0 2 782.42413 -3.76 21.89 1563.84099

QSTLVLFPGDLR MMP9 matrix metalloproteinase-9 preproprotein [Homo sapiens]

4318 NP_004985 4 1 74272287 N-Term(iTRAQ4plex) 1.546 1 0.722 1 1.212 1 1.678 1 1.451 1 2.009 1 1.197 1 45 4.18 0 3 723.05554 2.49 76.87 2167.15207

QSTNAYPDLR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 2 1 192447438 N-Term(iTRAQ4plex) 0.843 1 0.892 1 0.751 1 0.841 1 0.844 1 0.945 1 1.123 1 45 3.43 0 2 666.39417 0.49 37.4 1331.78105

QSTQTLYVNVAPR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 3 4507875 N-Term(iTRAQ4plex) 1.301 1 0.801 1 1.065 1 1.33 1 1.279 1 1.596 1 1.201 1 43 3.03 0 2 664.82605 -0.91 13.94 1328.64482

QSVEADINGLR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

9 6 195972866 N-Term(iTRAQ4plex) 1.33 1 0.98 1 1.252 1 1.277 1 1.382 1 1.409 1 1.103 1 38 3.04 0 2 907.46417 -5.47 31.46 1813.92107

QSWGLLGAPIQARDLGELLQAWGAGAK

CCDC22 coiled-coil domain-containing protein 22 [Homo sapiens]

28952 NP_054727 1 1 7661844 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

0.363 8 29.7 0.924 8 21.6 0.322 8 23 0.378 8 44.4 0.361 8 27.2 0.411 8 35.9 1.135 8 15.8 102 10.79 0 3 1372.1793 -1.44 40.82 2743.3458

QSWSVCK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

0.993 16 14.5 0.927 16 2.6 0.87 16 23.1 0.945 16 20.1 1.041 16 19.7 1.067 16 18.6 1.151 16 16.4 91 6.51 0 3 504.2915 -0.77 31.42 1510.85886

QTACKPEIAYAYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 4 2 38016947 N-Term(iTRAQ4plex); C4(Methylthio); K5(iTRAQ4plex); K13(iTRAQ4plex)

0.496 6 10.3 1.01 6 34.6 0.463 6 8.9 0.439 6 16.9 0.527 6 11.9 0.5 6 9.3 1.132 6 1.1 88 5.98 0 2 841.9176 0.86 27.69 1682.82659

QTCMK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 4 1 355594753 N-Term(iTRAQ4plex); C3(Methylthio); K5(iTRAQ4plex)

0.718 2 38 0.778 2 4.1 0.549 2 77.8 0.706 2 72 0.706 2 15 0.908 2 10.8 1.285 2 58 87 8.95 1 3 935.52069 1.36 47.33 2804.54752

QTEATMTFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.219 1 0.977 1 0.205 1 0.21 1 0.227 1 0.233 1 1.107 1 73 5.61 1 2 978.00958 -5.95 19.75 1955.01189

QTEATMTFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex); M6(Oxidation); K9(iTRAQ4plex)

0.511 2 0.1 0.815 2 28.5 0.485 2 3.8 0.595 2 24.5 0.445 2 22.1 0.546 2 6.1 0.917 2 18.2 57 8.56 0 3 865.7735 -0.53 28.21 2595.30594

QTHQPPAPNSLIR C1QC complement C1q subcomponent subunit C precursor [Homo sapiens]

714 NP_001107573 2 1 166235903 N-Term(iTRAQ4plex) 0.882 2 58.8 0.742 2 27.7 0.712 2 52.5 0.96 2 89.2 0.829 2 38.8 1.118 2 72 1.164 2 11.9 52 6.69 0 4 662.86627 0.25 65.87 2648.44326

QTIIVVLENVQR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 87 1 105990532 N-Term(iTRAQ4plex) 0.523 1 1.09 1 0.509 1 0.467 1 0.584 1 0.536 1 1.148 1 35 0 2 512.77979 -7.14 20.17 1024.55229

QTLDAGSQTSISGDIGVRSRSNLAEK

WWC2 protein WWC2 [Homo sapiens] 80014 NP_079225 1 1 156546890 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

0.977 1 0.852 1 0.878 1 1.032 1 0.931 1 1.093 1 1.06 1 3.88 2 4 734.15015 -2.57 35.84 2933.57876

QTMVDSSCR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C8(Methylthio)

1.396 1 0.836 1 1.173 1 1.402 1 1.39 1 1.662 1 1.186 1 71 6.25 0 2 810.94727 2.86 32.73 1620.88725

QTSPVSAMLVLVK EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 8 1 86788015 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.07 1 0.917 1 0.989 1 1.079 1 1.062 1 1.159 1 1.074 1 68 5.42 0 3 762.38745 0.7 69.27 2285.1478

QTVEAMK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 12 1 70778918 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.564 2 2.5 0.986 2 6.8 1.558 2 3 1.58 2 3.9 1.548 2 8.8 1.57 2 2 0.994 2 5.9 57 3.98 0 2 677.32428 0.69 30.81 1353.64079

QTVEAMK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 2 1 70778918 N-Term(iTRAQ4plex); M6(Oxidation); K7(iTRAQ4plex)

1.37 2 19.2 0.826 2 1.7 1.061 2 13.9 1.284 2 12.2 1.439 2 24.5 1.742 2 22.8 1.357 2 10.4 56 3.7 0 2 784.94818 -2.3 34.28 1568.88909

QTVSWAVTPK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.796 2 25.3 0.916 2 7.4 1.625 2 19.9 1.773 2 27.6 1.818 2 23.2 1.984 2 31 1.119 2 3.2 53 4.64 0 3 836.42859 0.35 23.81 1671.85215

QVCTDINECETGQHNCVPNSVCINTR

COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 2 1 40217843 N-Term(iTRAQ4plex); C3(Methylthio); C9(Methylthio); C16(Methylthio); C22(Methylthio)

1.366 2 8.5 1.085 2 18.7 1.287 2 19 1.187 2 0.3 1.565 2 17.8 1.443 2 0.9 1.216 2 1.3 53 4.77 0 3 657.35101 -0.53 56.31 1970.03849

QVEAALQPQTLR SERPINA11 serpin A11 precursor [Homo sapiens]

256394 NP_001073920 XP_170754

2 1 122937297 N-Term(iTRAQ4plex) 1.33 1 0.807 1 1.096 1 1.359 1 1.307 1 1.619 1 1.192 1 49 4.17 0 2 726.90106 -1.33 47.21 1452.79485

QVEGMEDWK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 30 1 4502337 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.513 1 1.148 1 1.401 1 1.22 1 1.85 1 1.611 1 1.321 1 49 5.26 0 3 852.47961 -3.18 43.44 2555.42429

QVEGMEDWK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 4 1 4502337 N-Term(iTRAQ4plex); M5(Oxidation); K9(iTRAQ4plex)

1.254 2 7 0.862 2 8.9 1.094 2 4.2 1.268 2 4.7 1.24 2 9.1 1.438 2 18.1 1.134 2 13.3 48 3.2 0 2 566.8266 1.44 31.14 1132.64592

QVFLYPEKDEPTYILNIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); K8(iTRAQ4plex); K18(iTRAQ4plex)

1.18 2 52.9 1.157 2 19 1.238 2 38.3 1.069 2 60.5 1.313 2 43.8 1.135 2 66.8 1.061 2 4.9 42 3.16 0 2 566.3642 -1.46 34.92 1131.72112

QVILTLQPTLVAVGK ICAM2 intercellular adhesion molecule 2 precursor [Homo sapiens]

3384 NP_001093256 8 1 153082686 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.409 1 0.9 1 1.257 1 1.397 1 1.42 1 1.577 1 1.129 1 42 3 0 2 611.34875 -2.21 13.92 1221.69023

QVLDNLTMEK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 6 2 55956899 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.573 1 0.946 1 1.415 1 1.497 1 1.644 1 1.739 1 1.162 1 40 4.07 0 2 731.336 1.63 35.19 1461.66472

QVLDNLTMEK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex); M8(Oxidation); K10(iTRAQ4plex)

1.422 1 0.977 1 1.263 1 1.293 1 1.548 1 1.584 1 1.226 1 39 3.39 0 2 570.31281 0.53 31.7 1139.61833

QVLLVGAPTYDDVSK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 8 1 29171717 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.322 2 13.8 0.776 2 18.3 1.108 2 2.8 1.427 2 21.2 1.244 2 8.5 1.602 2 27.1 1.123 2 5.6 37 5.83 0 3 811.8092 2.16 26.11 2433.41306

QVSGPLTSK SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 2 4 7382460 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.31 1 0.878 1 1.108 1 1.261 1 1.353 1 1.541 1 1.222 1 36 3.83 0 3 836.42859 0.35 23.81 1655.85898

QVTQSYWDTNPTR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 4 1 40317626 N-Term(iTRAQ4plex) 1.602 3 8.6 1.054 3 7.5 1.583 3 23.8 1.59 3 7.6 1.708 3 24.8 1.755 3 6 1.092 3 1.6 3.25 0 2 573.36981 -5.3 35.87 1145.73235

QVVAGLNFR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

36 2 4504893;156231037

N-Term(iTRAQ4plex) 0.85 1 1.055 1 0.801 1 0.759 1 0.946 1 0.896 1 1.18 1 100 4.63 0 2 779.44104 -5.86 16.57 1557.8748

QWAGLVEK APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 8 1 4557325 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.803 1 0.88 1 0.734 1 0.834 1 0.775 1 0.881 1 1.056 1 71 4.04 0 2 807.89459 -1.34 24.37 1614.78191

QWLEIDLLK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 6 1 105990535 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.976 1 0.898 1 0.987 1 1.098 1 0.866 1 0.964 1 0.877 1 68 6.79 0 3 740.76855 3.5 75.16 2220.29111

QYEEDILK CCDC66 coiled-coil domain-containing protein 66 isoform 2 [Homo sapiens]

285331 NP_001012524 NP_001132961 XP_376238

1 2 213688413 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.991 1 0.929 1 0.887 1 0.955 1 1.024 1 1.102 1 1.154 1 67 5.27 0 2 846.96478 -2.1 19.75 1692.92229

QYGFCK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 4 1 156523970 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

0.793 1 0.948 1 0.719 1 0.758 1 0.826 1 0.871 1 1.149 1 64 4.08 0 2 657.87891 0.53 30.18 1314.75054

QYKEMMEEANGQIAPENGTQTPSPPSEK

ITGAX integrin alpha-X precursor [Homo sapiens]

3687 NP_000878 XP_943090

1 1 34452173 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K28(iTRAQ4plex)

1.065 1 1.237 1 1.109 1 0.896 1 1.275 1 1.03 1 1.149 1 35 8.84 0 4 848.20398 2.2 79.91 3389.79409

QYLIMGK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.541 1 1.052 1 1.548 1 1.471 1 1.615 1 1.534 1 1.043 1 3.47 2 3 959.16968 5.41 65.78 2875.49448

QYMPWEAALSSLSYFK ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 8 1 157266300 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.488 2 26.3 0.894 2 24.5 0.41 2 41.6 0.458 2 15.9 0.517 2 36.2 0.579 2 11 1.262 2 4.8 99 5.52 0 2 846.91144 -0.09 16.06 1692.8156

QYNVGPSVSK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.998 1 0.775 1 0.894 1 1.154 1 0.878 1 1.133 1 0.982 1 63 4.61 0 3 807.40405 0.68 80.25 2420.1976

QYTDSTFR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 15 1 4557485 N-Term(iTRAQ4plex) 1.232 2 1.1 0.976 2 1.3 1.134 2 3.4 1.161 2 4.7 1.299 2 6.2 1.33 2 4.9 1.145 2 9.6 86 5.7 0 2 860.96582 -6.78 29.76 1720.92436

QYVEGSSIPVPTHYYSIITSCLDFTQPADK

ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 6 3 91823602 N-Term(iTRAQ4plex); C21(Methylthio); K30(iTRAQ4plex)

1.138 2 3.1 0.889 2 13.9 1.056 2 2.6 1.188 2 11.3 1.095 2 4.3 1.232 2 9.6 1.037 2 1.7 74 7 0 3 689.6507 -0.84 33.27 2066.93753

QYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQR

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 9 1 88853069 N-Term(iTRAQ4plex); C16(Methylthio); M30(Oxidation)

2.186 3 6.5 1.112 3 0.2 2.166 3 15.2 1.998 3 3.9 2.453 3 17.2 2.233 3 1.9 1.122 3 0.7 45 0 2 475.78882 -6.03 15.15 950.57585

QYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQR

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 19 1 88853069 N-Term(iTRAQ4plex); C16(Methylthio); M30(Oxidation); M31(Oxidation)

1.207 3 0.4 1.023 3 12.5 1.15 3 17.6 1.124 3 5 1.314 3 2.4 1.398 3 15 1.274 3 1.4 92 5.37 0 3 959.53656 1.81 73.25 1918.06528

QYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQR

VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 6 1 88853069 N-Term(iTRAQ4plex); C16(Methylthio)

1.16 1 0.769 1 0.904 1 1.175 1 1.149 1 1.494 1 1.271 1 54 4.2 0 3 661.70459 -0.47 40.17 1983.09922

QYYEGSEIVVAGR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 103 3 156119625 N-Term(iTRAQ4plex) 1.401 1 1.022 1 1.324 1 1.295 1 1.509 1 1.476 1 1.14 1 51 3.26 0 2 732.89905 -1.97 29.64 1464.79082

RAGSGTGVGAMLARGSASPHK

CXXC1 cpG-binding protein isoform 2 [Homo sapiens]

30827 NP_055408 1 2 156142180 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.082 2 21.7 0.985 2 27.4 1.051 2 4 1.067 2 31.6 1.106 2 12 1.123 2 40.3 1.053 2 8 49 3.09 0 2 623.41302 1.15 53.07 1245.81877

RAPDLQDLPWQVK PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 2 2 4506121 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.334 1 0.891 1 1.171 1 1.314 1 1.351 1 1.517 1 1.154 1 31 3.26 0 2 529.34607 -0.17 20.65 1057.68486

RAPQTGIVDECCFR IGF1 insulin-like growth factor 1 isoform 2 preproprotein [Homo sapiens]

3479 NP_001104754 2 4 163659901 N-Term(iTRAQ4plex); C11(Methylthio); C12(Methylthio)

1.361 52 9.9 0.972 52 14.3 1.295 52 16 1.341 52 14.9 1.409 52 13.6 1.445 52 11.4 1.106 52 7.6 132 6.97 0 3 934.06677 0.88 76.71 1867.12627

RAPSTWLTAYVVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 4 1 115298678 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.419 87 19.9 1.004 86 35.5 1.343 86 40.9 1.34 87 29.8 1.495 86 27.7 1.516 87 25.4 1.141 87 23 109 8.75 0 3 1377.2957 1.29 79.54 2753.58817

RAPYPNYDR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 2 3 221316614 N-Term(iTRAQ4plex) 1.114 14 9.3 0.895 14 17.7 1.052 14 24.2 1.096 14 28.9 1.167 14 18.3 1.223 14 14.7 1.085 14 27.6 106 10.19 1 3 1288.2703 1.76 67 2575.53325

RDFTFDLYR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 1 1 194018472 N-Term(iTRAQ4plex) 1.401 26 13.2 0.995 26 15.2 1.32 26 22.6 1.378 26 16.1 1.441 26 21.8 1.516 26 15.9 1.121 26 8 106 5.92 0 2 778.98267 -2.18 32.42 1556.95976

RDGYLFQLLR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 20 1 4504489 N-Term(iTRAQ4plex) 1.058 12 13.7 1 12 16.2 1.054 12 25.8 0.988 12 23.5 1.204 12 7.8 1.15 12 17.7 1.143 12 20.7 106 10.89 0 3 990.14655 0.15 55.46 2968.42545

RDVQNVAAAPELAMGALELESR

QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

2 2 13325075 N-Term(iTRAQ4plex) 1.604 19 17.9 0.923 19 14 1.394 19 16.6 1.458 19 28.1 1.696 19 27.6 1.809 19 17 1.154 19 11.8 97 6.22 0 3 1056.0466 3.87 72.98 2111.08599

REDFDVEAADSAGNCLDSLVFVAGDR

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 69 1 41393602 N-Term(iTRAQ4plex); C15(Methylthio)

1.174 2 11.1 1.215 2 34.9 1.314 2 29.4 1.081 2 5.1 1.304 2 31.2 1.073 2 3.4 0.992 2 1.8 93 7.75 0 3 990.14655 0.15 55.46 2984.42044

RELDESLQVAER CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 4 1 355594753 N-Term(iTRAQ4plex) 1.613 11 7 0.962 11 13.5 1.394 11 11.7 1.556 11 11.9 1.646 11 14.9 1.748 11 5.4 1.095 11 0.7 93 7.06 0 3 1021.6002 0.52 64.05 2042.19304

REPAVGEPAEVTTTVLVR ICAM1 intercellular adhesion molecule 1 precursor [Homo sapiens]

3383 NP_000192 2 1 167466198 N-Term(iTRAQ4plex) 1.104 35 6.9 0.954 35 10.1 1.013 35 12.2 1.064 35 9 1.146 35 11.1 1.191 35 9.3 1.135 35 12.9 90 5.95 0 3 821.44006 0.12 81.49 1641.87285

REQPGVYTK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 1 1 78191798 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.593 32 17.1 0.961 32 19.6 1.524 32 18.8 1.519 32 9.4 1.71 32 21.4 1.729 32 9 1.136 32 5.3 90 6.05 0 2 863.46008 -1.2 51.94 1725.91289

RFEQLELRPVLYNYLDK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.531 18 9 0.977 18 8.8 1.381 18 19.3 1.535 18 13.7 1.6 18 13 1.721 18 12.2 1.145 18 5.1 78 4.78 0 3 793.46362 0.45 45.32 1585.91997

RFNALQYLR LUM lumican precursor [Homo sapiens] 4060 NP_002336 10 1 4505047 N-Term(iTRAQ4plex) 1.659 25 21.1 0.971 25 10 1.482 25 29 1.563 25 29.5 1.701 25 29.7 1.782 25 27.7 1.146 25 5.4 75 5.6 0 3 821.44006 0.12 81.49 1657.87717

RGDACEGDSGGPFVMK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 2 1 4503635 N-Term(iTRAQ4plex); C5(Methylthio); K16(iTRAQ4plex)

0.786 4 39.2 0.965 4 19.2 0.695 4 41.2 0.712 4 39.2 0.86 4 31.7 0.88 4 33.7 1.099 4 4.9 75 6.37 0 3 1042.0443 -3.45 42.86 2083.08286

RGDSPWQVVLLDSK PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 4 1 4506115 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.423 38 14.1 1.04 38 12.9 1.345 38 22.3 1.377 38 9.6 1.526 38 19.5 1.563 38 8.8 1.115 38 4.2 72 4.48 0 3 678.37469 2.7 36.09 1355.7387

RGEQCVDIDECTIPPYCHQR

EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 4 1 86788015 N-Term(iTRAQ4plex); C5(Methylthio); C11(Methylthio); C17(Methylthio)

1.545 12 5.3 1.009 12 11.2 1.494 12 7.6 1.471 12 8.6 1.685 12 7.7 1.628 12 5.6 1.117 12 1.6 72 3.51 0 2 678.37469 2.7 36.09 1371.73833

RGHLFLQTDQPIYNPGQR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

12 6 178557739;67190748

N-Term(iTRAQ4plex) 1.906 11 17.2 1.03 11 32 1.977 11 18.9 1.844 11 9.9 1.98 11 28.1 1.99 11 5.9 1.128 11 5.8 71 4.21 0 2 706.94702 -0.04 45.06 1412.88542

RGPGGAWAAEVISDAR SAA1 serum amyloid A protein preproprotein [Homo sapiens]

6288 NP_954630 1 1 40316910 N-Term(iTRAQ4plex) 1.924 1 0.939 1 1.687 1 1.796 1 2.045 1 2.177 1 1.212 1 59 5.64 0 3 1042.0443 -3.45 42.86 2099.08261

RHLVPGAPFLLQALVR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

N-Term(iTRAQ4plex) 1.537 3 17.6 0.934 3 1.3 1.347 3 19.2 1.64 3 76.3 1.813 3 19.9 1.94 3 18.6 1.183 3 123.4 56 10.84 0 4 1143.8812 0.86 78.97 4572.50307

RHPDLSIPELLR AFM afamin precursor [Homo sapiens] 173 NP_001124 8 1 4501987 N-Term(iTRAQ4plex) 3.261 1 0.702 1 2.543 1 3.625 1 3.006 1 4.285 1 1.182 1 48 5.64 0 3 821.44006 0.12 81.49 1673.86264RIEDIHLLVER ENPP2 ectonucleotide

pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 1 3 91823602 N-Term(iTRAQ4plex) 1.549 16 17.6 0.93 16 16.1 1.36 16 28.8 1.541 16 6.9 1.577 16 25.3 1.738 16 12.1 1.146 16 4.2 44 2.93 0 2 532.29773 0.75 9.43 1063.58745

RIPIEDGSGEVVLSR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 12 1 115298678 N-Term(iTRAQ4plex) 1.678 5 3.4 1.082 5 7.8 1.677 5 2.4 1.54 5 3.4 1.848 5 4.3 1.683 5 3 1.093 5 1.3 43 2.78 0 2 504.77649 0.51 10.05 1008.54515

RLAAYLMLMR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex) 1.875 1 0.788 1 1.591 1 2.019 1 1.761 1 2.234 1 1.107 1 40 4.64 1 3 600.70844 -0.03 36.52 1800.11075

RLCFFYNK AFM afamin precursor [Homo sapiens] 173 NP_001124 1 1 4501987 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

1.796 3 18.7 0.922 3 63.3 1.769 3 23.8 2.612 3 23 1.978 3 43.8 2.371 3 27.6 1.09 3 3.8 6.38 0 6 808.76367 -3.21 68.78 4847.54565

RLDYQEGPPGVEISCWSVEL

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

94 2 31542984;262050538

N-Term(iTRAQ4plex); C15(Methylthio)

1.2 1 0.801 1 1.059 1 1.322 1 1.103 1 1.377 1 1.041 1 77 4.35 0 2 810.95331 -3.33 20.2 1620.89934

RLGVYELLLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

8 2 31542984;262050538

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.06 1 1.277 1 0.941 1 0.737 1 1.473 1 1.154 1 1.566 1 69 6.69 0 3 751.07098 -0.1 43.53 2251.1984

RLPGDIQVVPIGVGPNANVQELER

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 10 1 89191868 N-Term(iTRAQ4plex) 1.305 1 1.099 1 1.266 1 1.152 1 1.472 1 1.339 1 1.162 1 49 5.61 0 3 607.32123 -0.13 33.89 1819.94913

RLPLEYSYGEYR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 10 1 4557391 N-Term(iTRAQ4plex) 1.124 1 0.91 1 1.004 1 1.103 1 1.143 1 1.256 1 1.138 1 44 0 2 861.97028 1.6 22.41 1722.93328

RLTELLGAQDGALLVR TNFRSF6B tumor necrosis factor receptor superfamily member 6B precursor [Homo sapiens]

8771 NP_003814 1 1 4507585 N-Term(iTRAQ4plex) 1.175 1 0.854 1 1.02 1 1.195 1 1.158 1 1.357 1 1.136 1 38 3.06 0 2 594.83826 -1.07 20.61 1188.66924

RLTLQGIISWGSGCGDR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 15 1 145275213 N-Term(iTRAQ4plex); C14(Methylthio)

1.096 1 0.83 1 0.98 1 1.181 1 1.026 1 1.236 1 1.046 1 3.33 0 2 613.3363 -1.11 12.17 1225.66533

RLTVGAAQVPAQLLVGALR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 2 1 4557417 N-Term(iTRAQ4plex) 1.313 2 1.6 0.965 2 28.6 1.125 2 28.8 1.166 2 0.2 1.459 2 5.5 1.512 2 22.9 1.297 2 23.1 70 7.18 0 3 800.74451 -3.99 48.43 2400.22794

RLWWLDLK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 313 1 11321561 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.097 1 1.002 1 1.024 1 1.022 1 1.173 1 1.171 1 1.146 1 20 0 2 546.24384 -0.06 39.77 1091.48039

RMPITYDNGFLFIHTDKPVYTPDQSVK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); K17(iTRAQ4plex); K27(iTRAQ4plex)

1.318 2 0.2 1.021 2 2 1.264 2 1.2 1.239 2 3.2 1.399 2 2.6 1.371 2 0.6 1.107 2 3.8 93 5.11 0 2 844.9353 -5.97 31.11 1688.86333

RNDYLDIYAIGVGK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 10 3 14550407 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.172 2 4.6 0.95 2 1.5 1.107 2 0 1.165 2 1.5 1.177 2 10.3 1.239 2 8.8 1.063 2 10.3 82 5.07 0 2 762.44818 -2.15 55.61 1523.88909

RNPFVFAPTLLTVAVHFEEVAK

AFM afamin precursor [Homo sapiens] 173 NP_001124 24 1 4501987 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.23 2 9.6 0.882 2 5.4 1.072 2 20.9 1.215 2 15.4 1.24 2 4.6 1.407 2 0.8 1.158 2 16.2 80 4.91 0 2 837.96179 -1.79 51.48 1674.91631

RNTEILTGSWSDQTYPEGTQAIYK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 2 2 62739186 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.338 2 5.6 1.061 2 1.8 1.297 2 6 1.223 2 4.2 1.459 2 7 1.375 2 5.2 1.124 2 1 79 5.39 0 2 950.9942 -4.41 45.5 1900.98113

RPASPISTIQPK C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 4 1 166197660 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.324 2 14.4 0.779 2 13.1 1.083 2 9.3 1.389 2 22.6 1.275 2 8 1.636 2 21.2 1.178 2 1.3 68 5.3 0 3 1111.0723 -0.33 63.66 2221.13706

RPCFESLK AFM afamin precursor [Homo sapiens] 173 NP_001124 2 1 4501987 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

1.487 2 6.4 1.049 2 12.9 1.407 2 0.6 1.341 2 12.3 1.644 2 0.1 1.566 2 13 1.168 2 0.7 64 4.25 0 3 506.97491 -2.14 48.45 1518.91019

RPCGHPGDTPFGTFTLTGGNVFEYGVK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 107 2 62739186 N-Term(iTRAQ4plex); C3(Methylthio); K27(iTRAQ4plex)

1.332 1 0.936 1 1.152 1 1.231 1 1.426 1 1.523 1 1.238 1 41 3.15 0 2 509.2757 -0.46 9.7 1017.54411

RPDSLQHVLLPVLDR CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 6 1 42544239 N-Term(iTRAQ4plex) 0.558 1 1.039 1 0.526 1 0.506 1 0.611 1 0.588 1 1.16 1 38 0 2 588.31897 8.11 35.76 1175.63066

RPEDQELESLSAIEAELEK CHGA chromogranin-A preproprotein [Homo sapiens]

1113 NP_001266 2 1 4502805 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.445 3 2.5 1.074 3 2.4 1.416 3 0.9 1.405 3 1.6 1.565 3 3 1.474 3 1.3 1.059 3 2.9 38 4.14 0 3 770.91699 1.11 29.12 1540.81455

RPGDVWTLPDQCHTVTCQPDGQTLLK

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); C12(Methylthio); C17(Methylthio); K26(iTRAQ4plex)

1.356 2 2.4 0.927 2 5.8 1.216 2 6.6 1.311 2 0.8 1.397 2 3.9 1.507 2 1.9 1.149 2 2.7 27 2.89 0 2 722.33704 -1.89 36.14 1443.6668

RPGGEPSPEGTTGQSYNQYSQR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

24 5 47132549;16933542

N-Term(iTRAQ4plex) 0.582 11 28.9 1.032 11 16.9 0.57 11 27.8 0.657 11 56.4 0.526 11 24.2 0.592 11 29.2 1.093 11 11 109 7.09 0 3 930.97937 -0.96 31.31 1860.95146

RPGVYTQVTK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 1 2 295054188 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.773 10 9.1 0.967 10 13.1 0.744 10 20.1 0.736 10 7.7 0.816 10 18.1 0.831 10 9.8 1.142 10 1.7 63 4.79 0 2 742.90308 0.05 35.65 1484.79436

RPHFFFPK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 1 1 355594753 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.636 2 16.3 0.998 2 26.3 0.589 2 26.7 0.59 2 0.4 0.687 2 32.5 0.688 2 5.8 1.165 2 5.4 47 5.26 1 3 1254.656 -3.51 55.78 2508.30474

RPMKDETHFEVVESGR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex); M3(Oxidation); K4(iTRAQ4plex)

0.724 3 15.1 1.085 3 7.9 0.759 3 18.3 0.746 3 8.5 0.795 3 31.7 0.714 3 4.1 1.047 3 12.9 46 3.26 0 2 593.81171 -15.61 17.94 1186.63213

RPPGFSPFR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

2 3 4504893;156231037

N-Term(iTRAQ4plex) 1.714 4 31.2 0.751 4 11.3 1.303 4 29.4 1.834 4 32.9 1.63 4 29.4 2.394 4 15 1.163 4 6.4 101 6 0 2 882.95575 2.53 27.32 1764.90288

RPSCDIDKPPPNIELTGNGYNELTGQFR

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 9 1 45580688 N-Term(iTRAQ4plex); C4(Methylthio); K8(iTRAQ4plex)

1.665 6 4.4 0.874 6 9.6 1.407 6 6.8 1.693 6 10.4 1.625 6 3.7 1.898 6 15.9 1.069 6 13.7 98 9.74 0 3 958.8363 -0.79 64.11 2874.51322

RPSEIVIGQCK HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 4 1 4504489 N-Term(iTRAQ4plex); C10(Methylthio); K11(iTRAQ4plex)

0.776 7 14.6 1.011 7 6.9 0.686 7 6.5 0.659 7 10.4 0.797 7 17.2 0.836 7 22.7 1.162 7 7.8 98 5.54 0 2 896.4574 2.63 28.72 1791.90068

RPWNVASLIYETK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 18 1 4502511 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.191 6 8.1 0.871 6 16.9 1.986 6 9.2 2.182 6 19.6 2.15 6 6.2 2.343 6 10.6 1.071 6 3 94 5.76 0 2 821.45825 3.11 32.65 1641.90923

RPYFPVAVGK CFHR3;CFH complement factor H-related protein 3 isoform 2 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

10878;3075

NP_001160096;NP_000177

7 4 262231791;62739186

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.381 13 14 0.844 12 14 1.975 13 36.9 2.202 12 23 2.206 13 28.6 2.472 12 27.9 1.112 13 3.3 92 5.21 0 3 896.4574 2.63 28.72 1807.89458

Page 34: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

RQECSIPVCGQDQVTVAMTPR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 40 1 4503635 N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio)

1.505 13 9.8 0.953 13 10 1.269 13 17 1.454 13 14.7 1.549 13 16.9 1.632 13 4.8 1.115 13 8.2 89 5.71 0 2 937.97766 0.85 36 1874.94805

RQECSIPVCGQDQVTVAMTPR

F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 17 1 4503635 N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio); M18(Oxidation)

2.139 1 0.926 1 1.876 1 2.027 1 2.243 1 2.423 1 1.196 1 82 5.29 0 2 885.4577 2.42 32.6 1769.90813

RQNGAALTSASILAQQVWGTLVLLQR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 24 1 156616294 N-Term(iTRAQ4plex) 1.969 7 9.9 0.986 7 4.2 1.659 7 6.2 1.802 7 11.1 2.101 7 11 2.083 7 11 1.121 7 4.3 57 4.18 0 3 848.90936 -0.44 47.76 1696.81675

RQSEDSTFYLGER CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 4 1 4557485 N-Term(iTRAQ4plex) 1.343 3 0.2 0.963 3 12.7 1.252 3 2.4 1.28 3 2.9 1.4 3 4.1 1.448 3 0.6 1.094 3 5.7 54 4.77 0 2 848.90936 -0.44 47.76 1680.81413

RSSRLSEPWEGDFQEDHNANLWR

SHROOM3 protein Shroom3 [Homo sapiens] 57619 NP_065910 1 1 203098098 N-Term(iTRAQ4plex) 1.989 4 6.1 1.07 4 12.1 2.002 4 4 1.792 4 7.5 2.258 4 2.7 2.074 4 3.5 1.146 4 4 51 3.42 0 2 609.8501 -12.8 21.25 1218.70745

RTHLPEVFLSK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 1 2 32483410 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.688 3 7.2 1.013 3 7.2 0.648 3 4 0.64 3 0.1 0.737 3 16.8 0.735 3 1.6 1.147 3 1.5 49 4 0 2 678.29651 -1.29 47.2 1355.58684

RVDTVDPPYPR VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 7 1 88853069 N-Term(iTRAQ4plex) 1.538 4 6.5 1.098 4 14.1 1.53 4 11.4 1.398 4 15.7 1.662 4 7 1.473 4 17.1 1.107 4 4.7 47 3.21 0 2 546.79303 1.12 10.49 1092.57903

RVEPYGENFNK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 2 1 71773110 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.23 2 10 0.971 2 0.3 1.15 2 7.9 1.183 2 7.6 1.275 2 12.3 1.312 2 12 1.109 2 4.4 47 0 2 621.8172 -3.34 14.25 1242.62712

RWELCDIPR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 6 1 4505881 N-Term(iTRAQ4plex); C5(Methylthio)

2.734 5 22.2 0.958 5 16.3 2.261 5 19.1 2.706 5 12.7 2.571 5 20.1 3.078 5 12.7 1.13 5 1 46 0 2 678.29651 -1.29 47.2 1371.58415

RYTIAALLSPYSYSTTAVVTNPK

TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 4 1 4507725 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.544 3 0.9 1.044 3 0.3 1.498 3 0.7 1.438 3 0.4 1.654 3 1.4 1.587 3 1.1 1.104 3 0.7 44 3.86 0 2 696.3421 -1.09 11.68 1391.67827

RYTIAALLSPYSYSTTAVVTNPKE

TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 1 1 4507725 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

1.802 2 4.1 0.896 2 1 1.607 2 6.4 1.793 2 5.3 1.81 2 3 2.02 2 1.9 1.126 2 3.4 42 5.1 1 3 534.64423 -2.03 14.2 1601.91812

SAATLQQEK FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 4 1 34734066 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.624 7 6.4 0.951 7 6.4 2.122 7 20.2 2.448 7 29.7 2.387 7 14.1 2.601 7 15.7 1.092 7 4.1 42 0 2 621.8172 -3.34 14.25 1258.62663

SADTLWDIQK LDHB L-lactate dehydrogenase B chain [Homo sapiens]

3945 NP_002291 2 1 4557032 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.426 4 2.7 1.042 4 4.8 1.382 4 7.8 1.346 4 5.4 1.538 4 3.9 1.476 4 1 1.122 4 2.7 40 3.02 0 2 515.79187 0.24 24.58 1030.57707

SAFSVGLETYVTIPNMPIR ADIPOQ adiponectin precursor [Homo sapiens]

9370 NP_004788 5 1 4757760 N-Term(iTRAQ4plex) 1.679 3 5.6 0.995 3 5.5 1.605 3 9.9 1.643 3 1.7 1.744 3 13.4 1.77 3 1.5 1.086 3 1.2 40 3.22 0 2 556.83069 -0.34 32.8 1112.6552

SAFSVGLETYVTIPNMPIR ADIPOQ adiponectin precursor [Homo sapiens]

9370 NP_004788 1 1 4757760 N-Term(iTRAQ4plex); M16(Oxidation)

2.424 1 1.208 1 2.501 1 2.071 1 2.85 1 2.361 1 1.14 1 38 3.76 0 2 629.85199 7.53 26.34 1258.6967

SAGLVK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

4 2 31542984;262050538

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.393 3 5 0.96 3 14.1 1.412 3 10.7 1.368 3 16.4 1.576 3 3.3 1.382 3 16.8 1.01 3 0.3 35 3.39 0 2 546.8183 0.98 29.93 1092.62932

SAGSVESPSVSSTHR IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 4 2 62243068 N-Term(iTRAQ4plex) 2.191 2 3.1 0.971 2 23.6 2.042 2 15.5 2.102 2 7.9 2.291 2 14 2.359 2 9.4 1.122 2 1.5 35 3.74 0 2 589.32593 -0.05 31.69 1177.64458

SAGWTLATLGEQGLPHQSHRQR

SCNN1D amiloride-sensitive sodium channel subunit delta [Homo sapiens]

6339 NP_001123885 1 1 315259090 N-Term(iTRAQ4plex) 2 2 2.4 1.048 2 10.3 1.98 2 2.2 1.89 2 8 2.115 2 12.7 2.019 2 2.4 1.069 2 10.5 33 0 2 487.77313 0.23 23.97 974.53899

SALVLQYLR F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 5 1 4503649 N-Term(iTRAQ4plex) 1.813 2 6.1 0.964 2 4 1.67 2 7.4 1.731 2 3.4 1.892 2 8.7 1.961 2 4.7 1.133 2 1.3 2.88 0 2 481.25262 0.77 11.95 961.49797

SALYSPSDPLTLLQADTVR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

4 2 13325075 N-Term(iTRAQ4plex) 1.479 1 0.904 1 1.293 1 1.43 1 1.523 1 1.684 1 1.178 1 2.84 0 2 494.78833 -0.29 42.51 988.56938

SAQECQER F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 1 1 4503627 N-Term(iTRAQ4plex); C5(Methylthio)

1.02 8 10.7 1.006 8 18.1 0.955 8 19.1 0.933 8 13.9 1.077 8 23.9 1.106 8 22.8 1.083 8 6.6 105 7.42 0 3 1318.1587 2.8 66.21 2635.30112

SASNMAIVDVK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.083 5 8.2 0.976 5 8.8 0.952 5 18.8 1.021 5 22.9 1.007 5 2.9 1.081 5 6.9 1.079 5 5 84 6.01 0 3 1119.5527 -0.44 47.34 2238.09244

SASVGPPMEESVAHAVAAVGSR

MEGF8 multiple epidermal growth factor-like domains protein 8 precursor [Homo sapiens]

1954 NP_001401 XP_290821

4 1 145701025 N-Term(iTRAQ4plex) 0.951 3 3.4 0.974 3 23.1 0.837 3 5 0.871 3 2 0.927 3 10 0.959 3 1 1.1 3 1 78 6.25 0 3 1129.5147 0.34 55.99 2258.02164

SAVDAGFLQK DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.931 9 12.9 0.954 9 18.8 0.864 9 10.3 0.9 9 7.8 0.948 9 15.6 1.003 9 3.9 1.098 9 1.9 78 4.12 0 2 758.42542 -0.97 41.69 1515.8405

SCALDQNCQWEPR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 6 3 21450863 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio)

0.928 1 1.03 1 0.857 1 0.832 1 1.026 1 0.996 1 1.197 1 76 4.89 0 3 1256.6741 -2.94 74.2 3768.00766

SCALSNLACIR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 4 1 4503627 N-Term(iTRAQ4plex); C2(Methylthio); C9(Methylthio)

1.129 3 4.6 0.966 3 11.7 1.04 3 5.2 1.154 3 22.2 1.269 3 29.8 1.215 3 2 1.121 3 11.4 71 7.51 0 3 1213.1344 -0.74 48.88 2425.25718

SCAVAEYGVYVK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 136 3 4826762 N-Term(iTRAQ4plex); C2(Methylthio); K12(iTRAQ4plex)

1.107 3 1.6 0.881 3 18.1 1.02 3 18.6 1.108 3 6.7 1.084 3 12.8 1.231 3 5.3 1.066 3 0.4 62 4.94 0 2 974.00433 -4.56 37.14 1947.00139

SCCEEQNK AFM afamin precursor [Homo sapiens] 173 NP_001124 4 1 4501987 N-Term(iTRAQ4plex); C2(Methylthio); C3(Methylthio); K8(iTRAQ4plex)

0.997 2 0.1 0.968 2 14.4 0.922 2 6.4 0.952 2 7.9 1.042 2 7.3 1.076 2 7 1.129 2 0.9 56 3.53 0 2 702.86224 12.41 16.63 1404.71721

SCDIPVFMNAR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 18 1 62739186 N-Term(iTRAQ4plex); C2(Methylthio); M8(Oxidation)

0.901 1 1.118 1 0.707 1 0.633 1 1.2 1 1.073 1 1.697 1 50 7.56 1 4 633.31067 1.01 47.85 2530.22085

SCDIPVFMNAR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 32 1 62739186 N-Term(iTRAQ4plex); C2(Methylthio)

1.129 1 1.063 1 1.073 1 1.009 1 1.256 1 1.182 1 1.171 1 49 4.05 0 2 630.39777 -3.43 16.52 1259.78826

SCDNPYIPNGDYSPLR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 6 2 62739186 N-Term(iTRAQ4plex); C2(Methylthio)

0.806 3 28.3 0.97 3 26.1 0.799 3 18 0.735 3 8.7 0.935 3 11.8 0.863 3 9.2 1.171 3 0.5 48 4.03 0 2 788.37085 1.09 41.87 1575.73442

SCDVESNPGIFLPPGTQAEFNLR

SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 7 4 7382460 N-Term(iTRAQ4plex); C2(Methylthio)

0.9 2 0.6 0.904 2 4.3 0.8 2 0.9 0.885 2 5.2 0.913 2 3.4 1.011 2 0.8 1.142 2 4.4 48 3.81 0 2 671.35938 -1.2 20.78 1341.71147

SCEPAVPFPCGR F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 9 1 4503649 N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio)

0.977 4 3.1 0.944 4 11.3 0.898 4 3.6 1.033 4 12.6 0.967 4 6.4 1.064 4 4.9 1.031 4 7.2 48 6.76 0 3 909.77222 3.69 39.33 2727.3021

SCESNSPFPVHPGTAECCTK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 222 2 32483410 N-Term(iTRAQ4plex); C2(Methylthio); C17(Methylthio); C18(Methylthio); K20(iTRAQ4plex)

0.97 5 8.4 1.012 5 6.3 0.902 5 1.5 0.901 5 7.9 1.039 5 7 1.027 5 8 1.14 5 2 42 3.25 0 2 612.84875 0.9 23.54 1224.69023

SCEVVSVCLPLNLDTK PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 4 1 192447438 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); K16(iTRAQ4plex)

0.889 5 12.2 1.062 5 3.7 0.856 5 25 0.883 5 7.5 0.977 5 13.1 0.98 5 1.6 1.141 5 5 40 3.46 0 2 674.37115 0.77 49.12 1347.73467

SCGLHQLLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

N-Term(iTRAQ4plex); C2(Methylthio)

1.517 1 0.9 1 1.372 1 1.525 1 1.51 1 1.678 1 1.1 1 36 0 2 788.37085 1.09 41.87 1607.72783

SCQEVFDK B3GNT1 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Homo sapiens]

11041 NP_006867 4 1 5802984 N-Term(iTRAQ4plex); C2(Methylthio); K8(iTRAQ4plex)

1.164 1 1.022 1 1.117 1 1.093 1 1.236 1 1.21 1 1.107 1 34 0 2 788.37085 1.09 41.87 1591.72734

SCRPNDVTCVFDPVHTISHTVISLPTFR

FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 5 1 34734066 N-Term(iTRAQ4plex); C2(Methylthio); C9(Methylthio)

1.034 3 21.2 0.938 3 15.4 0.973 3 2.5 1.019 3 23.2 1.049 3 14.3 1.118 3 45.8 1.097 3 16.8 97 9.25 0 4 1032.859 1.28 56.73 3096.56118

SCVGETTESTQCEDEELEHLR

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 82 1 45580688 N-Term(iTRAQ4plex); C2(Methylthio); C12(Methylthio)

1.007 6 1.4 0.908 6 10.6 0.916 6 7.4 0.995 6 3.1 1.012 6 1.3 1.114 6 3.3 1.142 6 6.2 86 5.06 0 2 726.422 1.94 48.61 1451.83196

SCVNAIPDQCSPLPCNEDGYMSCK

PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 6 1 192447438 N-Term(iTRAQ4plex); C2(Methylthio); C10(Methylthio); C15(Methylthio); C23(Methylthio); K24(iTRAQ4plex)

1.075 9 9.8 1.074 9 11.8 1.127 9 14.2 1.041 9 5.7 1.234 9 15.1 1.176 9 5.4 1.121 9 4.3 76 4.22 0 2 729.86322 -1.35 27.55 1458.72392

SDACQGDSGGPLACEK HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 6 1 4504383 N-Term(iTRAQ4plex); C4(Methylthio); C14(Methylthio); K16(iTRAQ4plex)

1.169 3 1.5 0.861 3 12.2 1.028 3 10.6 1.127 3 9.4 1.097 3 1.1 1.275 3 4.7 1.096 3 5 76 5.21 0 3 976.53131 1.68 40.26 1952.0535

SDDEVDDPAVELK COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 2 5 55743098 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.857 22 14 0.919 22 20.7 0.805 22 20.8 0.879 22 23 0.93 22 13.2 0.981 22 11.6 1.133 22 17.9 75 9.38 0 4 941.86792 2.04 66.55 2823.58921

SDDKVTLEER C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); K4(iTRAQ4plex)

1.711 4 13 1.002 4 13.3 1.584 4 7.4 1.501 4 27.8 1.923 4 2.5 1.919 4 13.4 1.194 4 4.8 74 9.16 0 4 941.86792 2.04 66.55 2839.57436

SDEGTYMCVATNSAGHR ROBO4 roundabout homolog 4 precursor [Homo sapiens]

54538 NP_061928 2 1 17511435 N-Term(iTRAQ4plex); C8(Methylthio)

1.019 4 4.4 0.955 4 4.5 0.957 4 12.2 0.96 4 5.8 1.078 4 4.5 1.103 4 3 1.127 4 5.6 71 5.37 0 2 840.3833 -0.87 14.54 1679.75932

SDENEQHLGVK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 1 1 21264357 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.136 3 8.2 1.081 3 2.7 1.107 3 13.8 1.047 3 3.2 1.256 3 5.9 1.172 3 1.2 1.12 3 2.1 71 4.64 0 2 798.43164 0.6 43.79 1595.856

SDFSNEER C1S;MASP1;MASP1;MAS

P1

complement C1s subcomponent precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

716;5648;5648;5648

NP_958850;NP_001027019;NP_001027019;NP_001027019

19 4 41393602;21264359;73623026;21264357

N-Term(iTRAQ4plex) 1.161 1 0.793 1 0.972 1 1.225 1 1.11 1 1.399 1 1.142 1 70 4.49 0 2 777.43207 -2.05 34.37 1553.85686

SDIAPVAR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex) 1.202 1 0.952 1 1.101 1 1.156 1 1.246 1 1.309 1 1.132 1 66 3.33 0 2 1079.0609 -1.21 45.79 2157.11455

SDLAVPSELALLK LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 5 1 5031863 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.826 1 0.93 1 0.747 1 0.803 1 0.848 1 0.911 1 1.136 1 66 4.26 0 2 684.43463 0.48 17.87 1367.86199

SDLEMQYETLQEELMALK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 4 2 55956899 N-Term(iTRAQ4plex); M5(Oxidation); K18(iTRAQ4plex)

1.059 5 18.2 0.881 5 5.9 0.948 5 6.1 1.069 5 19.3 1.039 5 17.4 1.181 5 17.6 1.059 5 7.9 58 5.49 0 2 1079.0609 -1.21 45.79 2141.13481

SDLEMQYETLQEELMALK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.118 2 5.3 0.866 2 0.8 1.025 2 9.3 1.184 2 10.1 1.06 2 0.7 1.225 2 1.4 1.035 2 8.7 56 4.64 1 4 1112.6404 10.97 31.99 2224.27349

SDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 105 2 38016947 N-Term(iTRAQ4plex); C5(Methylthio); C40(Methylthio); K41(iTRAQ4plex)

1.357 11 11.3 1.006 11 15.1 1.298 11 25.4 1.293 11 14.3 1.532 11 21.9 1.423 11 10.1 1.177 11 8.8 123 6.88 0 2 999.49731 -0.08 27.02 1997.98735

SDTSLTWNSVK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.989 4 2.8 0.899 4 9.3 0.901 4 3.9 1.02 4 7 1.005 4 6 1.129 4 10.2 1.161 4 0.8 101 5.49 0 2 795.89929 -3.65 17.53 1590.79131

SDTVPSPR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

11 5 47132549;16933542

N-Term(iTRAQ4plex) 1.095 19 7.2 0.952 19 15.5 1.023 19 17 1.13 19 14.2 1.108 19 23.9 1.199 19 13.2 1.14 19 11.5 99 9.99 0 3 1036.8418 2.16 59.23 3108.51084

SDVDLMRTK IQCE IQ domain-containing protein E isoform 2 [Homo sapiens]

23288 NP_001093860 1 2 154813193 N-Term(iTRAQ4plex); M6(Oxidation); K9(iTRAQ4plex)

1.666 5 3.1 0.791 5 3 1.482 5 4.5 1.799 5 7 1.625 5 6 1.796 5 12.2 1.097 5 1.6 99 7.46 0 3 945.34601 -0.88 36.54 2834.00754

SDVGFLPPFPTLDPEEK AFM afamin precursor [Homo sapiens] 173 NP_001124 25 1 4501987 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.683 12 22.6 1.03 12 22.4 1.532 12 34.5 1.486 12 18.8 1.718 12 34.2 1.567 12 22.4 1.098 12 11.4 91 5.27 0 2 1107.5192 0.58 29.23 2214.03128

SDVMYTDWK ORM2 alpha-1-acid glycoprotein 2 precursor [Homo sapiens]

5005 NP_000599 4 1 4505529 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.124 5 2.2 1.016 5 6.5 1.941 5 3.7 1.911 5 6.6 2.278 5 3.3 2.251 5 2.7 1.174 5 4.2 90 9.03 0 3 787.0777 -2.21 44.3 2359.22513

SDVVYTDWK ORM1 alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5004 NP_000598 8 1 167857790 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.265 3 5 0.888 3 3 1.255 3 3.8 1.251 3 0.1 1.278 3 1.8 1.379 3 8.2 1.019 3 2 84 6.27 0 2 1074.9517 0.55 63.88 2148.90019

SEAACLAAGPGIR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 5 3 21450863 N-Term(iTRAQ4plex); C5(Methylthio)

1.517 60 10.2 0.909 60 16.4 1.375 60 15.8 1.477 60 14.7 1.556 60 13.2 1.679 60 11.5 1.138 60 10.4 82 8.62 0 3 787.0777 -2.21 44.3 2343.22319

SEALAVDGAGKPGAEEAQDPEGK

CHGA chromogranin-A preproprotein [Homo sapiens]

1113 NP_001266 2 1 4502805 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K23(iTRAQ4plex)

1.223 4 6.4 1.75 4 37.2 1.651 4 28.8 0.943 4 7.8 1.829 4 45.1 0.997 4 7 1.036 4 5.8 76 8.98 1 4 1248.6104 3.28 69.05 3743.82046

SEAYNTFSER F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 1.403 9 16.1 1.21 9 59.5 1.495 9 40.9 1.16 9 47 1.925 9 34.5 1.501 9 17 1.17 9 15.3 74 9.05 1 3 1248.6104 3.28 69.05 3759.80014

SEFPESWLWNVEDLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 28 1 115298678 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.522 5 39.6 1.067 5 9.4 2.125 5 59.4 2.536 5 20.2 2.427 5 67.6 2.922 5 14.8 1.112 5 3.9 74 5.23 0 2 818.35809 6.03 19.79 1635.67473

SEFPESWLWNVEDLKEPPK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 18 1 115298678 N-Term(iTRAQ4plex); K15(iTRAQ4plex); K19(iTRAQ4plex)

0.888 3 5.6 0.828 3 5.3 0.865 3 23.1 0.896 3 13.3 0.961 3 23.4 0.993 3 12.9 1.111 3 0.4 64 4.54 0 2 954.88159 -1.01 28.46 1908.75591

SEGSSVNLSPPLEQCVPDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 33 1 4503635 N-Term(iTRAQ4plex); C15(Methylthio)

1.333 7 6.9 0.967 7 6.1 1.222 7 3.1 1.181 7 11 1.4 7 10.8 1.411 7 7.9 1.142 7 1.2 58 5.04 0 2 882.40601 0.63 68.83 1763.80705

SEILAHWSPAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.797 2 5.4 0.972 2 16.9 1.665 2 15.3 1.713 2 1.6 1.886 2 12.4 1.939 2 4.5 1.132 2 2.9 56 3.12 0 2 645.83258 9.5 17.34 1290.65788

SEITELR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

2 2 195972866 N-Term(iTRAQ4plex) 3.062 4 8 0.932 4 7.5 2.925 4 6.1 2.998 4 12.9 3.126 4 3.2 3.087 4 15.6 1.089 4 7.6 54 4.8 0 3 882.40601 0.63 68.83 1779.79813

SELEEQLTPVAEETR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 25 1 4557325 N-Term(iTRAQ4plex) 1.062 2 12.1 0.985 2 3.8 0.974 2 14.1 0.989 2 10.2 1.134 2 14 1.151 2 10.1 1.165 2 0.1 53 5.22 1 3 507.62662 -3.71 19.82 1520.8653

SELTQQLNALFQDK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 34 1 71773110 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.07 8 4.6 1.013 8 9 1.016 8 7 0.992 8 3.1 1.164 8 3.6 1.138 8 1.9 1.132 8 2.6 53 3.99 0 2 624.83997 -1 26.59 1248.66936

SENINHNSAFK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 1 1 169636415 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.43 3 6.4 1.015 3 0.8 1.421 3 3.5 1.4 3 2.8 1.461 3 6.7 1.479 3 4 1.074 3 6.5 46 3.14 0 2 624.83997 -1 26.59 1264.66741

SETEIHQGFQHLHQLFAK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 6 1 73858564 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.44 2 13.6 0.625 2 7.1 1.083 2 19.5 1.733 2 12.3 1.257 2 13.6 2.012 2 6.5 1.161 2 5.8 45 3.53 0 2 1091.0212 -4.34 79.71 2181.0352

SEYGAALAWEK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 28 1 169636415 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.209 3 8.3 1.03 3 1.7 1.216 3 5.3 1.181 3 3.7 1.238 3 2.3 1.262 3 3.8 1.07 3 7.5 45 3 0 2 569.30377 -4.58 18.3 1137.60466

SEYMEGNVR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 N-Term(iTRAQ4plex) 1.278 2 2.3 0.995 2 8.8 1.198 2 0.7 1.204 2 9.5 1.352 2 4.5 1.359 2 4.3 1.129 2 5.2 44 0 2 569.30377 -4.58 18.3 1153.60015

SEYQADYESLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 21 1 105990532 N-Term(iTRAQ4plex) 1.648 1 0.873 1 1.502 1 1.722 1 1.584 1 1.815 1 1.054 1 43 3.79 0 3 447.60077 7.53 14.48 1340.78775

SFAAGIQALGGTNINDAMLMAVQLLDSSNQEER

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

56 2 31542984;262050538

N-Term(iTRAQ4plex); M20(Oxidation)

1.317 3 2.7 0.941 3 5 1.221 3 7.2 1.279 3 10.7 1.4 3 5.2 1.486 3 12.8 1.162 3 2 39 3.11 0 2 544.33691 -4.45 14.67 1087.67168

SFAAGIQALGGTNINDAMLMAVQLLDSSNQEER

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

38 2 31542984;262050538

N-Term(iTRAQ4plex) 1.339 2 25.4 1.002 2 8.6 1.26 2 23.9 1.257 2 33 1.421 2 18.3 1.418 2 27.3 1.128 2 5.4 29 0 2 532.21869 -0.39 14.38 1063.4301

SFDYHQFVDETNDK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 12 1 105990532 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.228 1 2.945 1 5.041 1 1.712 1 3.749 1 1.273 1 0.744 1 6.09 1 4 1248.6104 3.28 69.05 3775.78774

SFEGLGQLEVLTLDHNQLQEVK

IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 18 2 4826772 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.197 1 0.949 1 1.088 1 1.147 1 1.245 1 1.312 1 1.144 1 3.54 0 3 373.55695 0.19 12.88 1118.65628

SFEGNNNYDTPELR NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 2 5 66864913 N-Term(iTRAQ4plex) 1.519 9 29.5 0.977 8 126.4 1.613 9 41.4 1.37 8 50 1.8 9 69.4 1.686 8 89.3 1.043 9 36.5 109 10.57 0 3 1304.6135 5.08 75.16 3911.82602

SFFPENWLWR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

207 6 178557739;67190748

N-Term(iTRAQ4plex) 1.482 6 71.4 0.785 6 27.6 1.064 6 56.5 1.674 6 86.1 1.486 6 148.5 2.713 6 76.6 1.163 6 39.9 100 10.76 0 4 1304.6135 5.08 75.16 3927.81923

SFFSFLGEAFDGAR SAA2-SAA4;SAA1

SAA2-SAA2 protein precursor [Homo sapiens];serum amyloid A protein preproprotein [Homo sapiens]

100528017;6288

NP_001186673;NP_954630

2 4 315075331;40316910

N-Term(iTRAQ4plex) 1.029 40 40.2 0.943 40 16.4 0.938 40 21.7 0.995 40 32.4 0.979 40 50.7 1.151 40 23.2 1.043 40 22.8 99 9.17 0 4 1407.0459 -0.71 63.1 4219.131

SFGGQCR C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 3 1 45580688 N-Term(iTRAQ4plex); C6(Methylthio)

1.746 4 7 0.932 4 18.1 1.606 4 20.1 1.701 4 6.2 1.811 4 15.1 1.983 4 6.4 1.128 4 4.3 92 7.43 0 3 775.27899 -3.16 30.25 2323.82242

SFGMTPVLPAFAGHVPEAVTR

NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 2 1 66346698 N-Term(iTRAQ4plex) 1.622 41 23 0.931 41 16.8 1.359 41 24.6 1.499 41 22.3 1.581 41 32.1 1.815 41 30 1.148 41 17.1 91 7.77 0 3 802.41687 0.13 65.85 2405.23734

SFMLLILER SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 27 1 205277441 N-Term(iTRAQ4plex) 1.336 3 2.5 0.974 3 7.5 1.259 3 0.1 1.294 3 7.4 1.358 3 2.1 1.415 3 5.3 1.079 3 2 88 4.19 0 2 1033.0944 1.47 78.64 2065.18144

SFMLLILER SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 2 1 205277441 N-Term(iTRAQ4plex); M3(Oxidation)

1.263 2 11.2 1.054 2 18.2 1.249 2 2.9 1.185 2 15.2 1.349 2 6.4 1.28 2 24.8 1.08 2 9.3 80 6.51 0 3 1086.5846 -1.94 16.44 2172.1655

SFNPNSPGK PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 2 1 19923106 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.186 19 6.7 0.884 19 10.9 1.061 19 7.6 1.228 19 11.5 1.174 19 9.3 1.356 19 12.1 1.136 19 5 78 5.07 0 2 881.97809 1.84 54.99 1762.94878

SFPCFDEPAMK ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 2 1 157266300 N-Term(iTRAQ4plex); C4(Methylthio); K11(iTRAQ4plex)

1.199 5 3.1 1.006 5 6 1.179 5 18.5 1.193 5 3.5 1.345 5 16.9 1.329 5 11.9 1.143 5 4.4 77 3.8 0 2 734.82678 7.76 35.49 1468.6342

SFPTYCQQK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 22 1 119392081 N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

1.412 16 19.6 0.896 16 34.7 1.264 16 18.4 1.249 16 35 1.45 16 22.4 1.602 16 25.9 1.224 15 18.8 74 8.59 1 4 926.17352 1.74 59.33 2776.50273

SFQTGLFTAAR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 6 1 192447438 N-Term(iTRAQ4plex) 1.219 11 3.4 1.032 11 16 1.142 11 22.5 1.141 11 8.8 1.26 11 7.6 1.382 11 11 1.187 11 12.1 72 9.49 0 4 756.39001 -3.07 79.8 3022.53823

SFSGK ITIH1;ITIH3 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3697;3699 NP_002206;NP_002208

6 7 156119625;133925809

N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.203 8 11.8 0.933 8 6.9 1.141 8 7.8 1.195 8 9.6 1.268 8 13.4 1.334 8 12.6 1.123 8 2.2 67 5 0 3 511.62088 0.37 49.86 1532.84612

SFSTASAITPSVSR KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 2 1 119395754 N-Term(iTRAQ4plex) 1.344 5 8.7 0.992 5 9 1.202 5 0.8 1.242 5 12.8 1.344 5 6.2 1.423 5 10.1 1.119 5 4.1 66 5.42 1 3 563.96338 2.29 21.22 1689.86148

SFTIECR ICAM2 intercellular adhesion molecule 2 precursor [Homo sapiens]

3384 NP_001093256 2 1 153082686 N-Term(iTRAQ4plex); C6(Methylthio)

3.484 3 166.6 0.943 3 3.9 0.752 3 19.7 0.699 3 879.2 4.058 3 537.5 4.418 3 499.6 1.545 3 21.8 64 6.89 0 4 1407.0459 -0.71 63.1 4235.12661

SFVYVWK PMEL melanocyte protein PMEL isoform 2 precursor [Homo sapiens]

6490 NP_001186982 1 3 318037593 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.184 5 34.8 0.723 5 20.8 1.019 5 26.7 1.213 5 41 1.197 5 25.7 1.713 5 33.6 1.261 5 17 59 7.67 0 4 756.39001 -3.07 79.8 3038.55141

SFYANNHCIGTDLNR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 6 2 126273569 N-Term(iTRAQ4plex); C8(Methylthio)

1.599 2 9.1 0.967 2 8.8 1.486 2 15.1 1.537 2 6.3 1.66 2 11.9 1.717 2 3.1 1.117 2 3.2 59 3.98 0 2 511.62088 0.37 49.86 1548.8383

SFYFPMSIDK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 8 1 110611237 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.571 8 2.9 0.972 8 12.5 1.419 8 7.7 1.522 8 13.3 1.608 8 7.9 1.675 8 4.6 1.176 8 4 54 7.35 0 3 893.42523 -0.4 42.29 2678.25876

SFYFPMSIDK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 3 1 110611237 N-Term(iTRAQ4plex); M6(Oxidation); K10(iTRAQ4plex)

1.633 8 4.7 0.999 8 10.3 1.487 8 13.8 1.51 8 9.5 1.677 8 8.4 1.664 8 6.6 1.106 8 2.9 50 3.62 0 2 767.38733 -2.09 46.22 1533.75395

SGAGTEDSACIPWAYYSTVDQVK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 103 1 4557485 N-Term(iTRAQ4plex); C10(Methylthio); K23(iTRAQ4plex)

1.226 11 9.9 0.911 11 7.7 1.108 11 12.3 1.259 11 7.4 1.225 11 9.5 1.339 11 4.7 1.116 11 6.2 49 4.45 0 3 469.53314 3.03 45.01 1406.58487

SGALQIESSEESDQGK PTPRF receptor-type tyrosine-protein phosphatase F isoform 2 precursor [Homo sapiens]

5792 NP_569707 1 2 109633039 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.499 13 6.2 0.891 13 6.7 1.304 13 5 1.463 13 5.9 1.432 13 12.8 1.619 13 10.5 1.133 13 4.5 49 4.76 0 3 790.92273 0.37 31.78 1580.84214

SGAQATWTELPWPHEK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 441 1 11321561 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.187 2 3 0.974 2 6.6 1.134 2 10.2 1.165 2 3.6 1.209 2 2.5 1.242 2 4.1 1.066 2 7.7 49 5.31 0 3 580.62158 3.12 19.24 1739.85019

SGEATDGARPQALPEPMQESK

CHGA chromogranin-A preproprotein [Homo sapiens]

1113 NP_001266 2 1 4502805 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.185 5 5.2 0.922 5 28.8 1.089 5 18.3 1.145 5 4.7 1.269 5 12.7 1.355 5 5.7 1.165 5 2.3 45 3.45 0 2 582.81769 -0.94 29.42 1164.62578

SGELEQEEER CHGA chromogranin-A preproprotein [Homo sapiens]

1113 NP_001266 2 1 4502805 N-Term(iTRAQ4plex) 1.499 6 10.7 0.91 6 9.9 1.404 6 16.3 1.409 6 14.4 1.521 6 16 1.499 6 11.5 1.101 6 2.4 44 0 2 516.79834 -3.3 12.4 1032.5894

SGFPQVSMFFTHTFPK HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 33 1 4504489 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.927 7 20.9 0.874 7 10.4 1.715 7 10.9 1.968 7 15.3 2.028 7 18.3 2.188 7 21.4 1.173 7 8.4 36 4.52 0 3 790.92273 0.37 31.78 1596.83951

Page 35: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

SGFPQVSMFFTHTFPK HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 20 1 4504489 N-Term(iTRAQ4plex); M8(Oxidation); K16(iTRAQ4plex)

1.382 4 6.6 1.043 4 11.1 1.308 4 11 1.262 4 5.3 1.516 4 7.2 1.398 4 5.6 1.113 4 0.8 34 0 2 550.83221 -2.06 30.94 1100.65715

SGFSFGFK C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 10 1 4557391 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.837 7 26.2 0.882 7 16 1.448 7 29.2 1.866 7 18.5 1.815 7 31 1.986 7 20.4 1.15 7 10.1 148 7.64 0 3 1059.0569 3.25 55.58 2117.11155

SGFSSVSVSR KRT6A keratin, type II cytoskeletal 6A [Homo sapiens]

3853 NP_005545 NP_490596

2 1 5031839 N-Term(iTRAQ4plex) 2.086 3 1.4 0.941 3 4.5 1.789 3 8.3 1.902 3 1.9 2.243 3 3.7 2.285 3 10 1.186 3 1 98 5.65 0 2 961.09131 1.95 48.86 1921.17534

SGFTYVLHEGECCGR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C12(Methylthio); C13(Methylthio)

1.768 9 11.2 0.843 9 10.1 1.437 9 14.1 1.775 9 13 1.664 9 7.9 2.125 9 4.3 1.188 9 4.7 94 6.95 0 3 1067.04 1.21 36.95 2133.0728

SGGGFSSGSAGIINYQR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 4 2 119395750 N-Term(iTRAQ4plex) 1.8 4 4 1.133 4 4.8 1.71 4 16.2 1.576 4 4.9 2.032 4 5.5 1.801 4 10.8 1.161 4 7.2 92 6.48 0 3 761.43695 2.26 47.92 2282.2963

SGGGGGGGGCGGGGGVSSLR

KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

2 2 195972866 N-Term(iTRAQ4plex); C10(Methylthio)

1.999 5 8.8 1.079 5 12.1 1.942 5 13.9 1.822 5 2.9 2.212 5 16.5 2.062 5 3.5 1.139 5 5.1 66 3.84 0 2 624.86713 -1.6 28.48 1248.72832

SGGGGGGGLGSGGSIR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex) 2.119 13 14.1 0.858 13 25.8 1.854 13 25.7 2.13 13 8.1 2.086 13 20.6 2.427 13 15.7 1.107 13 4 51 6.6 0 3 743.77344 -2.82 65.92 2229.31821

SGGLCQPCR CFP properdin precursor [Homo sapiens] 5199 NP_001138724 2 1 223671861 N-Term(iTRAQ4plex); C5(Methylthio); C8(Methylthio)

1.398 1 0.796 1 1.106 1 1.39 1 1.404 1 1.764 1 1.269 1 51 5.95 1 3 693.0954 -0.52 43.27 2077.27164

SGIECQLWR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 56 1 4503635 N-Term(iTRAQ4plex); C5(Methylthio)

2.04 3 0.5 0.958 3 16.5 1.831 3 11.9 1.949 3 2.9 2.078 3 1.5 2.17 3 11.3 1.135 3 10.4 48 3.5 0 2 528.79926 -0.6 10.34 1056.59245

SGIPIVTSPYQIHFTK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 38 1 115298678 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

2.077 3 8.3 0.955 3 0.5 1.882 3 6.6 1.971 3 7.1 2.179 3 8.7 2.282 3 9.8 1.179 3 1.1 41 3.6 0 2 643.88892 0.3 45.99 1286.76921

SGKLEDIPAFFELAKK TTC21A tetratricopeptide repeat protein 21A isoform 1 [Homo sapiens]

199223 NP_001098983 1 2 290543551 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K15(iTRAQ4plex); K16(iTRAQ4plex)

1.408 2 9.5 0.955 2 21.4 1.32 2 6.3 1.382 2 28 1.437 2 7.4 1.504 2 13.9 1.089 2 13.7 40 8.55 1 4 625.34906 -2.3 54.21 2498.37441

SGLKTANLTGTDSPETDASASLQQNK

PARD3B partitioning defective 3 homolog B isoform a [Homo sapiens]

117583 NP_995585 1 3 119120907 N-Term(iTRAQ4plex); K4(iTRAQ4plex); K26(iTRAQ4plex)

1.27 1 1.084 1 1.112 1 1.026 1 1.534 1 1.416 1 1.38 1 38 3.87 0 3 458.90842 -13.95 26.7 1374.7107

SGLLGYVSGFGMEMGWLTTELK

C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 2 1 289547636 N-Term(iTRAQ4plex); M12(Oxidation); K22(iTRAQ4plex)

1.838 3 0.9 0.936 3 21.8 1.65 3 12.1 1.762 3 0.2 1.931 3 8 2.063 3 1.1 1.171 3 0.9 37 2.78 0 2 555.2821 0.48 38.8 1109.55791

SGLSTGWTQLSK A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 81 1 21071030 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.115 1 0.965 1 1.03 1 1.068 1 1.16 1 1.202 1 1.126 1 32 0 2 501.75235 0.12 19.73 1002.49742

SGPESPGSACR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 1 1 105990535 N-Term(iTRAQ4plex); C10(Methylthio)

1.653 44 10.2 1.018 44 11 1.558 44 15.3 1.558 44 8.8 1.75 44 14.4 1.717 44 7.6 1.136 44 7.8 124 5.89 0 2 874.45221 0.56 43.23 1747.89458

SGSAVANHADQGR LNX1 E3 ubiquitin-protein ligase LNX isoform b precursor [Homo sapiens]

84708 NP_116011 1 2 187607071 N-Term(iTRAQ4plex) 1.838 49 11.9 0.924 49 22.1 1.697 49 13.2 1.772 49 15 1.861 49 14.9 2.009 49 16.9 1.157 49 9.8 119 5.4 0 2 1117.5499 1.75 66.62 2234.08623

SGSDEVQVGQQR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 14 1 115298678 N-Term(iTRAQ4plex) 2.037 25 12 0.978 25 11.1 1.837 25 13.8 1.872 25 15 2.084 25 16.7 2.172 25 11.2 1.127 25 7.2 114 7.09 0 3 1158.096 4.21 29.78 2315.17197

SGSGLVGR CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 12 1 355594753 N-Term(iTRAQ4plex) 1.724 150 16.9 0.972 148 21.1 1.571 149 19.7 1.651 145 19.3 1.792 148 20.4 1.864 147 18.5 1.134 148 11.7 106 8.55 0 3 1316.1997 0.81 59.88 2631.39214

SGSSTASWIQNVDTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 15 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.551 6 11 0.902 6 9.8 2.261 6 11.8 2.469 6 8.4 2.352 6 18.8 2.801 6 6.5 1.245 6 6.3 102 8.08 0 3 1138.5094 1.26 44.66 3413.51584

SGVQMNTNFFHESGLEAHVALK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 16 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); K22(iTRAQ4plex)

1.553 49 37.6 0.943 49 31.2 1.38 48 44.9 1.329 47 50 1.672 47 42.5 1.725 47 39 1.136 45 18.5 100 8.93 1 3 1458.7754 3.35 50.86 2916.52724

SGVQQLIQYYQDQK APOF apolipoprotein F precursor [Homo sapiens]

319 NP_001629 4 1 4502165 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.638 77 9.2 0.971 77 12.5 1.543 77 14 1.56 77 12.6 1.681 77 12.7 1.739 77 13.4 1.115 77 10.1 99 5.8 0 2 874.00745 -1.41 59.79 1747.00762

SGWAIDPFGHSPTMAYLLNR

MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 2 1 51477714 N-Term(iTRAQ4plex) 1.716 103 27.6 0.943 102 29.7 1.626 103 30.8 1.657 102 37.2 1.758 103 30 1.87 102 34.3 1.069 103 22.3 95 7.94 0 3 938.45917 0.56 88.28 2813.36295

SGYLLHGSNEITCNR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 4 1 110611237 N-Term(iTRAQ4plex); C13(Methylthio)

1.476 10 10.9 0.964 10 16.8 1.321 10 19.7 1.41 10 12.6 1.654 10 15.1 1.727 10 6.1 1.207 10 16.8 95 9.85 0 3 1208.6388 -0.35 23.58 2416.27031

SHALQLNNR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

14 6 178557739;67190748

N-Term(iTRAQ4plex) 1.786 186 30.4 0.943 185 36.7 1.599 186 41.4 1.758 185 48.8 1.697 184 45.3 1.954 184 47.3 1.058 185 24.8 94 9.08 1 4 1150.2526 0.8 70.3 3448.74314

SHLIIAQVAK BTD biotinidase precursor [Homo sapiens]

686 NP_000051 2 1 4557373 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.838 23 8.8 0.892 23 12 1.626 23 10.3 1.802 23 18.1 1.769 23 13.2 2.011 23 9.4 1.122 23 8 93 10.03 0 3 1343.656 0.72 43.79 2686.30474

SIAQYWLGCPAPGHL VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 78 1 88853069 N-Term(iTRAQ4plex); C9(Methylthio)

1.704 24 22.7 0.95 24 15.6 1.609 24 31.4 1.608 24 24 1.809 24 39.2 1.768 24 27.4 1.087 24 9.9 93 7.55 0 3 938.45917 0.56 88.28 2829.35648

SICSTTNIQCK RNASE4 ribonuclease 4 precursor [Homo sapiens]

6038 NP_002928 2 1 4506557 N-Term(iTRAQ4plex); C3(Methylthio); C10(Methylthio); K11(iTRAQ4plex)

1.51 60 10.2 0.939 60 14.9 1.416 60 12.7 1.498 60 14.6 1.556 60 13.1 1.698 60 12 1.133 60 11.6 92 11.45 0 4 1570.7941 4.87 53.2 3140.56411

SICTLQITDTTGSHQFPAMQR

DIRAS2 GTP-binding protein Di-Ras2 [Homo sapiens]

54769 NP_060064 1 1 21703367 N-Term(iTRAQ4plex); C3(Methylthio); M19(Oxidation)

1.541 79 7.2 0.935 79 10.3 1.401 79 12.4 1.501 79 10 1.58 79 10.6 1.717 79 9.5 1.128 79 8.3 90 5.67 0 3 854.96545 -0.63 87.12 1708.92363

SIDGAYTIR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 2 3 4507875 N-Term(iTRAQ4plex) 1.75 21 9.4 0.934 21 21.6 1.609 21 9.1 1.677 21 21.5 1.761 21 9.5 1.973 21 14.5 1.109 21 7.3 90 6.08 0 2 1024.4623 -2.61 17.56 2047.91728

SIDVACHPGYALPK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 78 2 62739186 N-Term(iTRAQ4plex); C6(Methylthio); K14(iTRAQ4plex)

1.571 54 22.2 0.97 53 22.4 1.387 53 29.9 1.431 52 21.7 1.586 54 32.9 1.71 53 23.1 1.139 53 21.5 88 7.7 0 3 928.10223 -0.78 66.12 2782.30094

SIEVFGQFNGK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 29 1 4502511 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.75 117 9.4 0.988 117 10.3 1.637 117 13.5 1.657 117 9.1 1.835 117 12.7 1.847 117 9.1 1.12 117 5.8 88 4.57 0 2 740.4245 -4.52 43.79 1479.84172

SIIGMIDMFHK S100A7 protein S100-A7 [Homo sapiens] 6278 NP_002954 2 2 115298657 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.475 20 24.4 0.87 20 15.7 1.307 20 28.8 1.47 20 32.7 1.609 20 35 1.659 20 18.4 1.146 20 15.4 86 8.74 0 3 1138.5094 1.26 44.66 3397.52983

SIIQEK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 1 1 4502511 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.532 5 17.3 1.047 5 15.4 1.569 5 10.3 1.607 5 7.9 1.742 5 23.9 1.501 5 20.3 1.16 6 7.9 85 8.26 1 3 1294.1919 1.78 21.41 2587.37564

SILFLGK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 28 1 205277441 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.754 25 8.4 0.984 25 17.2 1.621 25 9.9 1.71 25 13.3 1.782 25 18.4 1.951 25 15.5 1.129 25 11.9 85 7.5 0 3 949.80975 -2.22 74.55 2847.41471

SILFVPTSAPR HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 2 1 4507677 N-Term(iTRAQ4plex) 1.978 103 11.8 1.138 103 21.2 2.006 103 18.1 1.759 103 13.1 2.141 103 16.3 1.978 103 13.8 1.106 103 10.7 82 8.85 0 3 1172.724 1.62 61.75 2344.4401

SILPK TTPAL alpha-tocopherol transfer protein-like [Homo sapiens]

79183 NP_077307 1 2 85861250 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.446 47 44.5 0.92 47 18.7 1.405 47 42 1.534 47 32.8 1.547 47 43.8 1.731 47 39.1 1.106 47 12.1 82 9.96 0 4 1570.7941 4.87 53.2 3156.57158

SILQMSLDHHIVTPLTSLVIENEAGDER

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 39 1 70778918 N-Term(iTRAQ4plex) 1.807 5 10.7 0.885 5 6.3 1.558 5 11.4 1.853 5 25.3 1.657 5 15.3 2.048 5 30.9 1.145 5 5.3 80 6.99 0 2 1294.5775 2.57 53.91 2588.14775

SILQMSLDHHIVTPLTSLVIENEAGDER

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 14 1 70778918 N-Term(iTRAQ4plex); M5(Oxidation)

1.653 3 25.4 0.99 3 14.7 1.663 3 37 1.627 3 4.7 1.626 3 61.7 1.642 3 16.4 1.126 3 21.2 80 8.83 1 4 1324.2716 -0.56 47.08 3970.7997

SIPQVSPVR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 7 1 4503011 N-Term(iTRAQ4plex) 3.567 1 0.881 1 3.279 1 3.721 1 3.43 1 3.893 1 1.046 1 78 3.79 0 2 778.89337 -4.79 15.46 1556.77947

SIQNNVR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

32 2 31542984;262050538

N-Term(iTRAQ4plex) 1.583 67 23.6 0.947 67 45.3 1.531 67 39.8 1.5 67 34.5 1.61 67 30.6 1.65 67 42.5 1.123 67 25.3 77 8.12 1 3 1344.7482 7.76 19.61 2688.44217

SISAALEHK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.721 6 6.8 0.944 6 2.5 1.634 6 8.2 1.685 6 6.2 1.77 6 7.6 1.81 6 5 1.082 6 2.2 76 5.7 0 3 734.91168 0.68 13.01 1468.81839

SISCQEIPGQQSR CFP properdin precursor [Homo sapiens] 5199 NP_001138724 6 1 223671861 N-Term(iTRAQ4plex); C4(Methylthio)

1.717 58 12.3 0.95 57 11.1 1.551 57 12.1 1.654 58 14.3 1.749 57 13.3 1.896 58 15.1 1.131 58 5.6 75 4.72 0 3 758.43555 -0.92 41.57 1515.86211

SISISVAGGGGGFGAAGGFGGR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 6 2 47132620 N-Term(iTRAQ4plex) 1.996 6 9.3 1.059 6 13.7 1.981 6 13.8 1.871 6 7.8 2.211 6 7.5 2.122 6 12.6 1.154 6 7.8 75 4.88 0 2 757.36951 3.73 16.99 1513.72856

SISISVAR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 6 2 119395750 N-Term(iTRAQ4plex) 1.771 85 7.8 0.961 85 13.5 1.618 85 10.1 1.692 85 13.2 1.872 85 12.5 1.947 85 14.5 1.152 85 7.6 74 6.47 1 3 1000.022 1.16 20.68 1999.03679

SITCIHGVWTQLPQCVAIDK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 206 1 62739186 N-Term(iTRAQ4plex); C4(Methylthio); C15(Methylthio); K20(iTRAQ4plex)

1.8 22 13 1.014 22 14.6 1.667 22 19.2 1.645 22 11.1 1.83 22 24.1 1.885 22 10.3 1.15 22 6.1 74 5.66 0 2 958.98346 -0.27 46.03 1916.95964

SITLFVQEDR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 4 1 40317626 N-Term(iTRAQ4plex) 1.89 49 11.2 0.969 49 6.9 1.808 49 11.5 1.78 49 14 1.999 49 14.6 2.028 49 12.3 1.139 49 5 72 5.1 0 2 788.37396 -0.08 23.89 1575.74004

SKDHEELSLVASEAVR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 6 2 126273569 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.943 3 1.1 0.858 3 26.7 1.684 3 12.6 1.962 3 12.3 1.835 3 1.4 2.119 3 4.8 1.146 3 7.8 71 7.28 0 4 1241.0542 3.72 36.18 2481.10171

SKEFMEEVIQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.771 31 18.8 0.927 31 22.8 1.547 31 23.3 1.796 31 34.1 1.875 31 26.5 1.908 31 25 1.189 31 28.7 70 7.75 0 3 1001.5245 1.53 67.54 3002.55887

SKELTTEIDNNIEQISSYK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

3 2 195972866 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K19(iTRAQ4plex)

1.661 1 0.809 1 1.424 1 1.76 1 1.58 1 1.953 1 1.11 1 70 4.08 0 2 778.89337 -4.79 15.46 1540.78118

SKEQLTPLIK APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 2 1 4502149 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K10(iTRAQ4plex)

1.849 7 23.4 0.938 7 19.9 1.806 7 20.7 1.768 7 18 1.924 7 33.7 2.051 7 15.8 1.076 7 11.2 69 5.11 1 3 942.45386 1.6 12.69 1883.89981

SKPTVSSSMEFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); K2(iTRAQ4plex); M9(Oxidation); K12(iTRAQ4plex)

1.203 3 1.7 1.113 3 14.7 1.202 3 15.7 1.14 3 17.5 1.431 3 16.5 1.286 3 31.8 1.322 3 58.8 69 6.01 0 3 1189.9078 -0.04 76.23 3567.70896

SLAAYTAACQAAGVAVKPWR

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C9(Methylthio); K17(iTRAQ4plex)

1.679 11 21.7 0.889 11 16.5 1.418 11 31.7 1.723 11 19.7 1.735 11 33.7 2.065 11 22.9 1.154 11 8.7 68 3.78 0 3 740.4245 -4.52 43.79 1495.83721

SLADELALVDVLEDK LDHB L-lactate dehydrogenase B chain [Homo sapiens]

3945 NP_002291 6 1 4557032 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.237 6 19.4 0.93 6 18.4 1.865 6 23 2.168 6 8.5 2.447 6 29.5 2.524 6 8.3 1.164 6 8.1 68 7.46 1 3 1390.2483 4.23 53.11 2779.48001

SLAELGGHLDQQVEEFR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 81 1 71773110 N-Term(iTRAQ4plex) 2.262 9 25.2 0.943 9 12.4 1.365 9 65.4 0.995 9 46.3 2.293 9 37 2.432 9 74.6 1.254 10 34.7 67 7.69 0 3 1458.7191 2.67 80.15 4374.1428

SLAELGGHLDQQVEEFRR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 6 1 71773110 N-Term(iTRAQ4plex) 1.694 166 14.2 0.851 164 21.4 1.433 164 18.7 1.715 166 20.7 1.681 164 17.5 2.006 166 20.4 1.16 166 13.6 64 9.51 0 3 940.4892 1.26 32.81 2819.45304

SLALGTFAHTPALASLGLSNNR

IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 26 2 4826772 N-Term(iTRAQ4plex) 1.76 138 8.8 0.94 138 7.3 1.612 138 9.2 1.706 138 9.4 1.825 138 9.8 1.936 138 8 1.136 138 4.9 63 4.94 0 2 832.42596 -0.11 3.51 1663.84404

SLAPTAAAK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 30 1 70778918 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.071 1 0.94 1 1.931 1 2.055 1 2.086 1 2.22 1 1.08 1 62 4.41 0 2 764.85425 0.41 12.64 1528.70122

SLAPYAQDTQEK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 8 1 71773110 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.286 2 6.9 1.033 2 25.5 1.283 2 5.3 1.242 2 19.9 1.341 2 6.4 1.298 2 18.8 1.045 2 1.1 61 4.95 1 3 866.42615 1.8 17.76 1731.84592

SLDEISQPAQELK COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 2 5 55743098 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.7 21 12.7 0.971 21 7.6 1.539 21 17 1.669 21 8.5 1.816 21 19.8 1.879 21 9.3 1.126 21 4.3 61 4.04 0 3 449.88132 -0.26 29.77 1347.6294

SLDFNTLVDNISVDPETGDLWVGCHPNGMK

PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 2 1 19923106 N-Term(iTRAQ4plex); C24(Methylthio); K30(iTRAQ4plex)

1.304 9 29.6 0.935 9 24.1 1.477 9 33.2 1.579 9 77.4 0.978 9 57.2 1.03 9 27.6 0.701 9 71.4 60 8.14 0 3 1458.7191 2.67 80.15 4358.15512

SLDFNTLVDNISVDPETGDLWVGCHPNGMK

PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 2 1 19923106 N-Term(iTRAQ4plex); C24(Methylthio); M29(Oxidation); K30(iTRAQ4plex)

1.92 6 24.3 1.081 6 12.7 1.697 6 49.8 1.968 6 5.2 1.914 6 41.3 2.082 6 16.8 1.055 6 8.8 60 3.95 0 2 739.87946 5.19 16.52 1478.7387

SLDFTELDVAAEK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 64 1 4557287 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.763 48 14.7 0.946 48 11.8 1.548 48 20.9 1.695 48 15.1 1.769 48 16.9 1.919 48 13.8 1.143 48 5.6 58 4.3 0 2 739.87946 5.19 16.52 1462.75102

SLDLDSIIAEVK KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 16 2 119395750 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.858 2 29.5 1.059 2 8.3 1.871 2 16.2 1.767 2 24.8 1.95 2 33.8 1.842 2 43 1.042 2 16.9 57 6.01 0 3 1241.0542 3.72 36.18 2497.0878

SLDLSK LRR1 leucine-rich repeat protein 1 isoform 1 [Homo sapiens]

122769 NP_689542 3 1 45439342 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.868 2 13.9 1.103 2 17.1 1.792 2 21.2 1.625 2 4 2.143 2 24.6 1.944 2 7.3 1.196 2 3.3 55 5.16 0 3 679.65167 -1.28 18.6 2036.94046

SLEDLQLTHNK LUM lumican precursor [Homo sapiens] 4060 NP_002336 4 1 4505047 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.586 12 25 1.019 12 7.7 1.408 12 21.6 1.477 12 30.4 1.599 12 20 1.657 12 31.7 1.132 12 1.9 55 3.73 0 2 594.82123 -12.74 17.41 1188.64922

SLEMTFIPTIEDTGK VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 3 3 4507875 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.772 10 8.5 0.905 10 11.4 1.483 10 13.4 1.823 10 9.5 1.777 10 13.5 2.026 10 8.8 1.112 10 2.9 54 4.18 0 2 699.3056 -0.78 12.43 1397.60417

SLEVWGSQEALEEAKEVRQENR

XPA DNA repair protein complementing XP-A cells [Homo sapiens]

7507 NP_000371 1 1 4507937 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.71 47 17.5 0.912 47 24.9 1.56 47 22.2 1.724 47 31.4 1.745 47 28.5 1.845 47 22.2 1.093 47 23.5 53 7.09 1 4 969.45001 -12.81 25.13 2906.33548

SLEYLDLSFNQIAR LUM lumican precursor [Homo sapiens] 4060 NP_002336 22 1 4505047 N-Term(iTRAQ4plex) 1.551 1 1.079 1 1.544 1 1.431 1 1.68 1 1.558 1 1.088 1 48 5.16 1 2 968.52209 -2.56 26.93 1936.03691

SLFTDLEAENDVLHCVAFAVPK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); C15(Methylthio); K22(iTRAQ4plex)

1.903 5 10.7 1.029 5 12.5 1.744 5 21.7 1.752 5 4.9 2.117 5 19 2.057 5 1.5 1.174 5 1.1 46 3.32 0 2 645.80688 9.02 15.25 1290.59722

SLFTDLVAEK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 5 1 162809334 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.525 13 18.8 0.867 13 32 1.963 13 45.7 2.509 13 39.6 2.447 13 29.4 3.09 13 36 1.094 13 13.5 45 7.66 1 4 969.45001 -12.81 25.13 2922.35586

SLFWENSHLLVNSFADNTR BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 4 1 168229159 N-Term(iTRAQ4plex) 1.52 2 10.1 0.89 2 39.6 1.349 2 5.9 1.517 2 33.1 1.547 2 9.7 1.739 2 29.1 1.146 2 3.8 44 9.38 1 4 878.71527 2.34 48.78 3511.83925

SLGECCDVEDSTTCFNAK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 234 2 32483410 N-Term(iTRAQ4plex); C5(Methylthio); C6(Methylthio); C14(Methylthio); K18(iTRAQ4plex)

1.928 3 27.4 0.851 3 2 1.423 3 12.9 1.91 3 32.7 2.265 3 1.4 2.649 3 0.6 1.124 3 73.6 44 6.31 1 3 1390.2483 4.23 53.11 2795.4686

SLGFCDTTNK C1QA complement C1q subcomponent subunit A precursor [Homo sapiens]

712 NP_057075 26 1 7705753 N-Term(iTRAQ4plex); C5(Methylthio); K10(iTRAQ4plex)

1.938 2 35.8 0.953 2 0.3 1.633 2 27.7 1.713 2 28 2.148 2 41.9 2.253 2 42.2 1.315 2 13.1 41 6.12 2 3 1004.4617 -0.57 16.7 3011.37064

SLGNVIMVCR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 36 2 62739186 N-Term(iTRAQ4plex); C9(Methylthio)

1.392 4 39.5 0.639 4 68.5 1.03 4 115.4 1.575 4 9.5 1.405 4 59.9 1.873 4 10.9 1.171 4 11.9 41 8.55 2 4 963.00537 0.95 55.99 3849.00161

SLGNVIMVCR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 4 2 62739186 N-Term(iTRAQ4plex); M7(Oxidation); C9(Methylthio)

1.418 2 11.3 1.002 2 19.3 1.247 2 27.6 1.244 2 8 1.596 2 16.1 1.593 2 3.1 1.28 2 11.1 41 4.73 0 3 1294.5775 2.57 53.91 2604.13016

SLGPNSCSANGPGLYLIHGPNLYCYSDVEK

HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 35 1 11321561 N-Term(iTRAQ4plex); C7(Methylthio); C24(Methylthio); K30(iTRAQ4plex)

1.857 2 5.5 0.921 2 5.6 1.679 2 11.5 1.823 2 5.9 1.888 2 5.2 2.049 2 0.4 1.124 2 6.2 38 0 2 517.30524 -0.1 11.11 1033.60271

SLLEGEGSSGGGGR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

4 2 195972866 N-Term(iTRAQ4plex) 1.702 2 1.2 0.854 2 1.8 1.493 2 5.8 1.749 2 4 1.661 2 1.4 1.945 2 3.2 1.112 2 7.2 38 3.07 0 2 632.82458 0.55 8.39 1264.64189

SLLQPNK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 4 1 4557389 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.952 2 3.4 0.994 2 10.7 1.799 2 2.9 1.81 2 7.8 2.093 2 13.8 2.106 2 3.1 1.163 2 10.9 37 0 2 454.75006 0.1 0.53 908.49285

SLMLHYEFLQR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 25 1 4557391 N-Term(iTRAQ4plex) 1.808 8 12 0.912 8 13.8 1.57 8 22.7 1.756 8 4.6 1.845 8 18.9 1.984 8 6.8 1.132 8 2.4 37 3.23 0 2 581.28333 -5.43 24.8 1161.55937

SLMLHYEFLQR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 9 1 4557391 N-Term(iTRAQ4plex); M3(Oxidation)

1.927 6 8.1 0.982 6 6.3 1.771 6 7.5 1.827 6 3.5 2.024 6 6.3 2.091 6 4.2 1.129 6 1.3 36 0 2 456.77432 2.27 14.17 912.54137

SLMLSYNAITHLPAGIFR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

6 1 256217721 N-Term(iTRAQ4plex) 1.971 1 0.911 1 1.777 1 1.95 1 1.989 1 2.184 1 1.12 1 36 0 2 523.83392 0.47 15.05 1046.66057

SLMLSYNAITHLPAGIFR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

1 1 256217721 N-Term(iTRAQ4plex); M3(Oxidation)

1.203 3 30.1 0.943 3 0 0.938 3 1.5 0.995 3 1.5 1.408 3 58.3 1.494 3 58.3 1.043 3 17 35 5.31 0 4 1458.7191 2.67 80.15 4342.1476

SLNEEAVK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.627 5 9.3 0.919 5 15.6 1.42 5 35.3 1.444 5 56 1.806 5 51.3 1.92 5 10.6 1.332 5 41.2 32 6.84 0 4 1152.2922 4.18 60.92 4606.13344

SLNNQFASFIDK KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 12 2 119395750 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.455 8 22.2 0.999 8 15.3 1.329 8 62.5 1.411 8 33.1 1.533 8 30.4 1.688 8 7.9 1.135 8 30 30 9.14 0 4 999.4942 1.41 49.09 3994.96499

SLNNQFASFIDKVR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 2 2 119395750 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.489 2 7.5 0.937 2 15.4 1.357 2 13 1.447 2 2.3 1.533 2 16.8 1.635 2 1.4 1.13 2 3.7 26 0 2 372.23068 1.15 9.19 743.45409

SLPAPWLSMAPVSWITPGLK

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 124 1 21071030 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.74 6 21.4 0.734 6 56.6 1.55 6 15.6 2.127 6 82 1.427 6 13.4 1.799 6 28.1 1.072 6 42.8 26 6.97 0 5 1152.2922 4.18 60.92 4622.13148

SLPAPWLSMAPVSWITPGLK

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 38 1 21071030 N-Term(iTRAQ4plex); M9(Oxidation); K20(iTRAQ4plex)

1.684 4 6.5 0.87 4 15.2 1.484 4 12.9 1.769 4 1.8 1.681 4 10.9 2.049 4 3.1 1.153 4 2 25 2.94 0 2 537.25275 -0.6 29.78 1073.50945

SLPEGVANGIEVYSTK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 8 1 133925809 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.377 1 1.292 1 1.3 1 1.006 1 1.856 1 1.436 1 1.428 1 4.45 1 4 597.33704 -9.34 28.61 2386.32631

SLPGESEEMMEEVDQVTLYSYK

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 2 1 70778918 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

0.873 1 0.972 1 0.811 1 0.834 1 0.91 1 0.936 1 1.122 1 53 3.34 0 2 607.82025 5.58 23.43 1214.63323

SLPGFSHMAPLPK APOF apolipoprotein F precursor [Homo sapiens]

319 NP_001629 1 1 4502165 N-Term(iTRAQ4plex); M8(Oxidation); K13(iTRAQ4plex)

2.475 7 8.3 0.904 7 4.6 2.13 7 17.1 2.401 7 3.5 2.445 7 12.9 2.742 7 8.1 1.128 7 3.4 75 4.68 0 2 718.34271 -0.03 22.51 1435.67778

SLPTCLPECGQPSR MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 4 1 21264359 N-Term(iTRAQ4plex); C5(Methylthio); C9(Methylthio)

2.079 1 1.102 1 2.072 1 1.881 1 2.297 1 2.084 1 1.108 1 72 5.45 0 2 822.46649 -3.8 20.01 1643.92571

SLPTCLPVCGLPK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 9 1 21264357 N-Term(iTRAQ4plex); C5(Methylthio); C9(Methylthio); K13(iTRAQ4plex)

2.599 1 0.83 1 2.175 1 2.621 1 2.581 1 3.111 1 1.187 1 69 6.62 0 3 1043.833 3.08 51.03 3129.48447

SLPVSDSVLSGFEQR C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 25 1 166197660 N-Term(iTRAQ4plex) 2.227 7 7.5 1.088 7 2.6 2.061 7 19 2.088 7 15.5 2.425 7 17.8 2.313 7 11.8 1.109 7 3.4 65 3.25 0 2 620.36932 -2.12 43.47 1239.73113

SLSQQIENIR COL1A1 collagen alpha-1(I) chain preproprotein [Homo sapiens]

1277 NP_000079 1 1 110349772 N-Term(iTRAQ4plex) 2.028 4 20.7 0.948 4 16.9 1.879 4 33.2 1.965 4 15.1 2.046 4 28.4 2.204 4 7.7 1.09 4 4.3 63 5.11 0 2 740.87848 -1.09 33.61 1480.74968

SLSTELFK MYH7 myosin-7 [Homo sapiens] 4625 NP_000248 3 7 115496169 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

2.892 1 0.944 1 2.592 1 2.744 1 3.032 1 3.211 1 1.17 1 59 4.89 0 2 932.98914 -2.58 63.19 1864.97099

SLTEEAENWGDGEPNNK SELL L-selectin precursor [Homo sapiens] 6402 NP_000646 4 1 262206315 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

2.237 4 15 0.887 4 21.5 1.851 4 12.7 2.408 4 6.2 2.107 4 18 2.742 4 8.9 1.132 4 3.5 50 3.61 0 2 560.81549 0.48 16.74 1120.62261

SLTLDVQGR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 4 3 4507875 N-Term(iTRAQ4plex) 2.26 1 1.023 1 2.142 1 2.094 1 2.43 1 2.376 1 1.135 1 48 3.21 0 2 532.29047 4.67 24.14 1063.57366

SLTLGIEPVSPTSLR VASN vasorin precursor [Homo sapiens] 114990 NP_612449 2 1 88702793 N-Term(iTRAQ4plex) 2.078 2 12.2 0.966 2 0.5 1.91 2 11.7 1.977 2 11.1 2.176 2 13.2 2.252 2 12.6 1.139 2 1.5 34 0 2 532.29047 4.67 24.14 1079.5645SLTSCLDSK APOM;APO

Mapolipoprotein M isoform 2 [Homo sapiens];apolipoprotein M isoform 2 [Homo sapiens]

55937;55937

NP_001243098;NP_001243098

6 2 22091452;371873523

N-Term(iTRAQ4plex); C5(Methylthio); K9(iTRAQ4plex)

0.942 2 33.7 0.638 2 13.5 0.725 2 26.9 1.137 2 41.5 0.819 2 29.1 1.283 2 43.8 1.129 2 2.1 3.88 0 2 770.39728 -17.69 26.7 1539.78728

SLVCNGDSDCDEDSADEDR

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 4 1 45580688 N-Term(iTRAQ4plex); C4(Methylthio); C10(Methylthio)

1.173 1 0.886 1 1.015 1 1.146 1 1.197 1 1.352 1 1.179 1 45 3.59 0 2 795.89819 0.65 33.2 1590.78911

SLVELTPIAAVHGR ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 3 preproprotein [Homo sapiens]

11093 NP_620595 4 3 21265043 N-Term(iTRAQ4plex) 1.031 1 1.142 1 1.06 1 0.928 1 1.149 1 1.006 1 1.084 1 42 6.27 0 3 663.67981 -0.88 41.58 1989.02488

SLVWEYWAGLLVCAFWIPDSRGMPHVIR

GRIK3 glutamate receptor, ionotropic kainate 3 precursor [Homo sapiens]

2899 NP_000822 1 1 28605145 N-Term(iTRAQ4plex); C13(Methylthio)

0.72 1 1.118 1 0.724 1 0.648 1 0.801 1 0.717 1 1.107 1 2.91 0 2 688.88208 -6.93 19.29 1376.75688

SLWDFLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 39 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.467 3 8.1 0.919 3 40.4 1.406 3 13.1 1.327 3 4.7 1.566 3 10.7 1.478 3 7.1 1.114 3 0 94 4.76 0 2 790.40442 -4.95 21.46 1579.80156

SLWNGDTGECTDNAYIDIQLR

KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

14 2 4504893;156231037

N-Term(iTRAQ4plex); C10(Methylthio)

0.961 2 11.6 0.882 2 1 0.832 2 13.6 0.944 2 12.6 0.976 2 10.7 1.108 2 9.7 1.174 2 2.8 87 5.16 0 2 764.93335 1.95 32.49 1528.85942

SLYVSATVILHSGSDMVQAER

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 46 1 115298678 N-Term(iTRAQ4plex) 1.259 3 3.9 0.994 3 24.5 1.07 3 1.7 1.077 3 7 1.181 3 7.3 1.515 3 1.6 1.062 3 11.6 69 7.89 0 3 1108.5248 2.89 47.43 3323.5466

SLYVSATVILHSGSDMVQAER

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 12 1 115298678 N-Term(iTRAQ4plex); M16(Oxidation)

0.928 9 13.5 0.917 9 7.1 0.926 9 9.1 1.001 9 15.2 0.946 9 8.6 0.951 9 15.2 1.163 9 16.5 67 7.16 0 3 1144.6355 0.22 72.42 2288.26755

Page 36: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

SMEDK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 1 1 133925809 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

0.99 2 3.4 1.062 2 16.5 0.936 2 1.6 0.882 2 15 1.108 2 8.1 1.043 2 8.3 1.183 2 6.5 61 4.2 0 2 784.40625 -0.48 31.87 1567.80425

SMMQSLSQNPDLAAQMQNPDTLSAMSNPR

UBQLN1 ubiquilin-1 isoform 2 [Homo sapiens]

29979 NP_444295 1 1 16753205 N-Term(iTRAQ4plex) 1.093 2 0.6 1.002 2 12.2 1.024 2 5.4 1.022 2 6.7 1.166 2 5.5 1.164 2 6.6 1.139 2 0.1 58 4.61 0 2 778.37842 -0.88 31.98 1555.75151

SMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

9 6 178557739;67190748

N-Term(iTRAQ4plex); K39(iTRAQ4plex)

1.214 2 2.1 0.934 2 0.1 1.108 2 5.6 1.187 2 5.7 1.239 2 1.1 1.327 2 1 1.118 2 6.7 53 3.16 0 2 784.40625 -0.48 31.87 1583.79131

SMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLK

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

14 6 178557739;67190748

N-Term(iTRAQ4plex); M2(Oxidation); K39(iTRAQ4plex)

0.989 2 7.3 0.795 2 4.9 0.805 2 12.5 1.012 2 7.5 0.97 2 7.1 1.219 2 2.1 1.204 2 5.4 49 4.63 0 2 720.34857 0.45 51.75 1439.69133

SNALDIIFQTDLTGQK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 61 1 41393602 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.988 2 5.6 0.999 2 7.7 0.939 2 0.1 0.94 2 7.7 1.037 2 3.4 1.038 2 11.1 1.104 2 3.4 41 4.14 0 3 994.98621 0.81 31.28 1988.96482

SNLDEDIIAEENIVSR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 26 1 115298678 N-Term(iTRAQ4plex) 0.808 2 37.1 0.884 2 40 0.656 2 113.3 0.742 2 56.2 0.842 2 25.5 0.952 2 13.4 1.282 2 73.5 37 5.93 0 4 1067.0834 0.85 78.05 4265.31557

SNLISGSVMYIEEK PCYOX1 prenylcysteine oxidase 1 precursor [Homo sapiens]

51449 NP_057381 2 1 166795301 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.602 2 9.5 0.909 2 7 1.407 2 2.6 1.548 2 9.6 1.652 2 9.2 1.817 2 16.3 1.174 2 6.6 116 5.47 0 2 1140.9171 6.62 24.43 2280.82695

SNMGGSPK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 6 3 14550407 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.492 41 11.7 0.996 41 14.5 1.438 41 20.2 1.402 41 11.5 1.526 41 13.3 1.516 41 15 1.091 41 14.6 115 9.26 0 3 877.69806 -0.15 33.63 2631.07962

SNPDQADVDHDFVGDACDSDQDQDGDGHQDSR

COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 2 1 40217843 N-Term(iTRAQ4plex); C17(Methylthio)

1.456 10 25 0.975 10 20.6 1.414 10 40.4 1.48 10 33.1 1.615 10 39.8 1.725 10 42.5 1.168 10 17.6 109 7.41 0 3 1213.1332 -0.49 63.6 2425.25908

SNTVASLHTEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.196 5 27 0.919 5 7.5 1.019 5 20.1 1.109 5 22.5 1.297 5 10.2 1.388 5 25.8 1.141 5 3.4 104 6.37 0 3 1542.6794 2.43 38.39 3084.34897

SPAFTDLHLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 33 1 105990532 N-Term(iTRAQ4plex) 1.314 5 11.6 0.961 5 3.6 1.167 5 5.7 1.23 5 10.1 1.399 5 9.9 1.356 5 11.5 1.102 5 11.5 94 6.36 0 2 1130.0598 4.62 40.24 2259.11235

SPAGPTVVSIGGGK DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 2 1 116534900 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.108 12 9.5 0.908 12 10.7 0.994 12 15 1.076 12 10.2 1.139 12 7.8 1.235 12 5.2 1.157 12 8.3 91 6.99 0 3 1201.1019 2.53 33.48 2401.18943

SPDGDSSLAASER MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 14 1 4557739 N-Term(iTRAQ4plex) 1.87 4 17.2 0.868 4 10.8 1.619 4 19.5 2.012 4 3.4 1.874 4 19.8 2.131 4 12.4 1.125 4 4.2 88 5.89 0 3 1082.9351 1.35 48.96 2164.86747

SPDVINGSPISQK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 4 2 62739186 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.235 6 3.7 0.988 6 12.9 1.171 6 4.9 1.182 6 5.3 1.299 6 6.8 1.322 6 9.2 1.105 6 8.1 87 5.46 0 2 957.97858 -0.62 48.86 1914.94988

SPELQAEAK APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 33 1 4502149 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.16 1 0.988 1 1.018 1 1.031 1 1.288 1 1.304 1 1.265 1 86 4.98 0 2 1082.9351 1.35 48.96 2148.87041

SPENSLDPK PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 2 1 70780384 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.227 8 10.4 1.038 8 21.7 1.185 8 18.1 1.173 8 9.4 1.301 8 18.1 1.254 8 1.5 1.098 8 6 85 5.95 0 2 872.49506 -3.18 40.94 1743.98076

SPEQQETVLDGNLIIR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

180 2 31542984;262050538

N-Term(iTRAQ4plex) 1.954 4 20.1 0.869 4 1.4 1.644 4 33.2 1.913 4 30.2 1.977 4 12.2 2.3 4 9.4 1.094 4 6.2 84 9.88 1 3 861.12378 -1.78 44.28 2581.35678

SPLNDFQVLR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex) 1.806 4 23.9 0.999 4 16.4 1.829 4 18.5 1.853 4 16.8 1.759 4 7.9 1.967 4 31.5 1.04 4 19.6 80 4.93 0 2 957.97858 -0.62 48.86 1930.94512

SPPEISHGVVAHMSDSYQYGEEVTYK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 7 1 62739186 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

0.917 1 0.742 1 0.681 1 0.918 1 0.917 1 1.236 1 1.347 1 78 6.83 0 3 899.75732 -3.54 67.02 2697.25742

SPPEISHGVVAHMSDSYQYGEEVTYK

CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 4 1 62739186 N-Term(iTRAQ4plex); M13(Oxidation); K26(iTRAQ4plex)

1.016 10 16.6 0.903 10 24.2 0.928 10 24.2 0.997 10 5.5 1.048 10 19.1 1.186 10 6.1 1.149 10 2.7 78 4.13 0 2 693.32391 -2.56 41.33 1385.64507

SPPGVCSR SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 2 1 115583663 N-Term(iTRAQ4plex); C6(Methylthio)

1.449 16 8.8 0.965 16 14.7 1.339 16 11.5 1.413 16 6.6 1.488 16 11.9 1.54 16 10.8 1.116 16 6.1 73 5.53 0 3 979.49329 0.85 34.97 1957.9793

SPPTMVDSLLAVTLAGNLGLTFLR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 8 1 156616294 N-Term(iTRAQ4plex); M5(Oxidation)

1.389 12 13 1.069 12 15.6 1.333 12 22.7 1.293 12 8.1 1.564 12 22.5 1.45 12 3.3 1.122 12 5.4 72 4.04 0 2 682.42395 -2.43 39.85 1363.83513

SPPTMVDSLLAVTLAGNLGLTFLR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 4 1 156616294 N-Term(iTRAQ4plex) 1.393 5 10.1 1.009 5 9.4 1.319 5 13.3 1.32 5 9.3 1.491 5 7.9 1.42 5 2.3 1.077 5 3.9 71 4.59 0 2 728.35327 -4.78 18.33 1455.69927

SPQELLCGASLISDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 54 1 4503635 N-Term(iTRAQ4plex); C7(Methylthio)

1.536 4 7.6 0.978 4 3.6 1.399 4 11.9 1.444 4 5.2 1.623 4 9.9 1.771 4 8.6 1.157 4 2.9 70 4.11 0 2 815.85321 -0.05 18.51 1630.69914

SPQGLGAFTPVVR PTPRS receptor-type tyrosine-protein phosphatase S isoform 2 precursor [Homo sapiens]

5802 NP_570924 2 4 104487297 N-Term(iTRAQ4plex) 1.501 12 7.7 0.967 12 13.3 1.334 12 4.5 1.423 12 4.7 1.548 12 14.2 1.615 12 8.4 1.113 12 9 69 6.59 0 3 1047.5775 0.16 62.47 2094.14775

SPSQADINK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 30 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.224 4 12.7 1.064 4 5.1 1.15 4 17.8 1.141 4 6.1 1.309 4 13.2 1.298 4 9.6 1.168 4 2.3 69 5.17 0 3 782.87878 -11.14 23.87 1564.76035

SPVGVQPILNEHTFCAGMSK

HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 22 2 4826762 N-Term(iTRAQ4plex); C15(Methylthio); K20(iTRAQ4plex)

1.351 10 7.1 0.952 10 5.6 1.207 10 7.6 1.291 10 7 1.355 10 7.3 1.47 10 8 1.108 10 4.6 69 4.14 0 2 687.80463 0.6 20.87 1374.60198

SPVGVQPILNEHTFCAGMSK

HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 14 2 4826762 N-Term(iTRAQ4plex); C15(Methylthio); M18(Oxidation); K20(iTRAQ4plex)

1.142 7 11.1 1.02 7 6.3 1.061 7 21.6 1.041 7 17 1.21 7 14.4 1.164 7 14.1 1.14 7 5.6 68 4.36 0 2 637.85016 -0.26 12.19 1274.69304

SPVTLLAAVMSLPEEHNK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 12 1 31652249 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.37 40 36.7 0.999 39 38.3 1.28 40 46.7 1.253 39 23.2 1.341 40 46.4 1.27 39 32.4 1.089 40 30.7 68 7.71 0 3 1005.8548 1.29 76.32 3015.54782

SPVTLLAAVMSLPEEHNK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 3 1 31652249 N-Term(iTRAQ4plex); M10(Oxidation); K18(iTRAQ4plex)

1.37 6 15.4 0.994 6 19.1 1.332 6 26.3 1.291 6 7.6 1.504 6 24.9 1.489 6 11.1 1.128 6 2.8 67 2.99 0 2 610.86914 -3.21 39.47 1220.731

SPWCDVFDIDDAK MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 7 2 19923761 N-Term(iTRAQ4plex); C4(Methylthio); K13(iTRAQ4plex)

1.538 1 0.834 1 1.342 1 1.609 1 1.478 1 1.772 1 1.101 1 67 7.3 0 3 899.75732 -3.54 67.02 2713.26834

SPYIDK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.154 15 10.9 0.998 15 15.4 1.128 15 16.2 1.099 15 11.1 1.203 15 14.2 1.249 15 10.8 1.123 15 3.7 66 3.96 0 2 694.3894 0.26 31.3 1387.77153

SQAIATK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.157 9 10.7 1.12 9 17.1 2.264 9 39.3 2.207 9 18.5 2.295 9 37.4 2.05 9 30 1.057 9 12.6 66 8.33 0 4 1122.264 -1.7 46.86 3364.78896

SQASSCSLQSSDSVPVGLCK

FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 4 1 58331240 N-Term(iTRAQ4plex); C6(Methylthio); C19(Methylthio); K20(iTRAQ4plex)

1.337 7 5.4 0.971 7 7.5 1.261 7 10.5 1.341 7 4.4 1.37 7 13.6 1.448 7 6.7 1.103 7 5.1 65 5.5 0 3 815.85321 -0.05 18.51 1614.70548

SQCLEDHTWAPPFPICK C4BPB C4b-binding protein beta chain isoform 2 precursor [Homo sapiens]

725 NP_001017364 9 2 62912462 N-Term(iTRAQ4plex); C3(Methylthio); C16(Methylthio); K17(iTRAQ4plex)

1.04 7 8.9 1.111 7 15.3 1.029 7 18.3 1.058 7 5.2 1.137 7 16.3 1.127 7 7 1.077 7 3.3 64 4.29 0 2 676.80713 -0.28 27.77 1352.60576

SQCTYSNPEGTVVLACDQAQCR

CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

4 1 256217721 N-Term(iTRAQ4plex); C3(Methylthio); C16(Methylthio); C21(Methylthio)

1.342 2 0.9 0.891 2 26.9 1.182 2 12.7 1.328 2 13.9 1.365 2 10.7 1.533 2 15.9 1.155 2 2 59 3.86 0 2 692.90521 -0.53 26.2 1384.7957

SQDILLSVENTVIYR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 16 1 192447438 N-Term(iTRAQ4plex) 1.873 5 130.5 0.998 4 33.3 1.413 5 22.8 1.516 4 28.4 2.274 5 100.2 1.779 4 58.1 1.477 5 12.7 58 8.87 0 4 867.17871 -5.9 37.38 3465.67592

SQEFLEDADR VCAM1 vascular cell adhesion protein 1 isoform a precursor [Homo sapiens]

7412 NP_001069 4 3 4507875 N-Term(iTRAQ4plex) 1.748 2 5.3 1.04 2 19.4 1.654 2 18.8 1.591 2 0.5 1.918 2 12.1 1.845 2 7.2 1.159 2 6.6 53 2.88 0 2 499.28156 0.14 14.68 997.55583

SQETGDLDVGGLQETDK FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

3 4 34734066;34734062

N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.243 4 4.5 0.97 4 3.9 1.193 4 8.4 1.183 4 7.8 1.329 4 3.9 1.377 4 6.1 1.138 4 3.4 51 0 2 583.81427 5.19 17.08 1166.62126

SQFVQPICLPEPGSTFPAGHK

HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 6 1 4504383 N-Term(iTRAQ4plex); C8(Methylthio); K21(iTRAQ4plex)

1.068 14 9.6 1.022 14 15 1.005 14 16.2 1.041 14 8.6 1.093 14 13.9 1.143 14 14.3 1.106 14 7.9 51 8.22 0 4 1122.264 -1.7 46.86 3348.79775

SQIFSTASDNQPTVTIK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 4 1 16507237 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.094 1 0.743 1 0.877 1 1.181 1 1.029 1 1.384 1 1.173 1 43 3.46 0 2 552.8327 7.06 16.46 1104.65813

SQPMGLWR AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 2 1 4502337 N-Term(iTRAQ4plex) 1.331 5 5.5 0.914 5 8.3 1.148 5 2.7 1.264 5 3.8 1.391 5 7.2 1.451 5 5.4 1.119 5 6.9 42 4.45 0 2 687.2569 -0.72 30.34 1373.50652

SQPNLDTCAFHEQPELQK CST1;CST2;CST4

cystatin-SN precursor [Homo sapiens];cystatin-SA precursor [Homo sapiens];cystatin-S precursor [Homo sapiens]

1469;1470;1472

NP_001889;NP_001313;NP_001890

6 3 19882251;4503105;4503109

N-Term(iTRAQ4plex); C8(Methylthio); K18(iTRAQ4plex)

1.524 4 5.5 0.922 4 7.9 1.348 4 4.7 1.49 4 8.9 1.543 4 3 1.688 4 10.4 1.116 4 3.3 27 0 2 464.68436 -0.73 7.44 928.36144

SQVEPETR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 3 1 4503011 N-Term(iTRAQ4plex) 1.391 2 1 0.889 2 12.4 1.224 2 6.9 1.377 2 5.5 1.406 2 6.8 1.582 2 5.6 1.149 2 0.1 25 2.82 0 2 472.71429 1.49 14.75 944.42168

SQVFNILR CECR1 adenosine deaminase CECR1 isoform a precursor [Homo sapiens]

51816 NP_059120 1 1 29029550 N-Term(iTRAQ4plex) 1.452 1 1.056 1 1.441 1 1.364 1 1.545 1 1.463 1 1.072 1 3.67 1 3 423.92291 1.15 11.21 1269.75418

SQYEQLAEQNR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

8 2 195972866 N-Term(iTRAQ4plex) 2.23 1 0.473 1 1.773 1 3.744 1 1.513 1 3.196 1 0.854 1 3.8 0 4 903.20105 2.3 80.72 3609.78237

SSALDMENFR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 43 1 70778918 N-Term(iTRAQ4plex) 0.96 4 7.9 0.996 4 25.5 0.955 4 8.1 0.855 4 4.2 1.028 4 8 0.924 4 1 1.076 4 0.3 100 5.72 0 2 952.39868 0.19 21.58 1903.77605

SSALDMENFR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 13 1 70778918 N-Term(iTRAQ4plex); M6(Oxidation)

0.738 1 0.934 1 0.69 1 0.738 1 0.737 1 0.789 1 1.069 1 63 4.14 0 2 853.95465 -0.36 34.59 1706.90203

SSCGSLR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

4 1 256217721 N-Term(iTRAQ4plex); C3(Methylthio)

1.319 1 0.97 1 1.234 1 1.273 1 1.364 1 1.406 1 1.105 1 60 4.13 0 2 853.95465 -0.36 34.59 1722.89653

SSCTLFQDIFQHLDK MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 2 2 19923761 N-Term(iTRAQ4plex); C3(Methylthio); K15(iTRAQ4plex)

1.152 1 1.174 1 1.231 1 1.049 1 1.274 1 1.085 1 1.034 1 42 1 2 565.87347 -9.12 20.02 1130.73967

SSEDPNEDIVER IGJ immunoglobulin J chain precursor [Homo sapiens]

3512 NP_653247 2 1 21489959 N-Term(iTRAQ4plex) 1.854 1 0.863 1 1.575 1 1.825 1 1.878 1 2.176 1 1.192 1 40 0 2 683.34906 -0.36 12.32 1365.69084

SSEMPELTSMHTLLLR MPO myeloperoxidase precursor [Homo sapiens]

4353 NP_000241 2 1 4557759 N-Term(iTRAQ4plex) 2.071 1 0.469 1 1.451 1 3.091 1 1.593 1 3.393 1 1.098 1 3.92 0 4 858.44025 -1.99 66.37 3430.73916

SSFTVQDLKPFTEYVFR IL6ST interleukin-6 receptor subunit beta isoform 1 precursor [Homo sapiens]

3572 NP_002175 1 3 28610147 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.197 1 0.814 1 1.018 1 1.25 1 1.155 1 1.418 1 1.135 1 39 5.39 0 3 571.29083 3.43 16 1711.85794

SSFVAPLEK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 4 1 39725934 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.171 1 0.979 1 1.112 1 1.135 1 1.207 1 1.232 1 1.086 1 36 2.81 0 2 576.78937 8.01 29.3 1152.57146

SSGAFWK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 4 1 4502337 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.702 2 53.9 0.817 2 21.5 0.576 2 82.9 0.705 2 54.6 0.699 2 53.1 0.855 2 29.2 1.213 2 22.8 57 6.58 0 3 1524.7221 1.28 62.28 4572.15158

SSGLVSNAPGVQIR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 4 1 4557892 N-Term(iTRAQ4plex) 119 6.59 0 3 1029.0536 0.14 25.72 2057.09909

SSGQWQTPGATR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 8 1 14550407 N-Term(iTRAQ4plex) 117 6.42 0 3 1203.1659 1.84 48.25 2405.32743

SSIDIENGFISESQYTYALK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 14 1 62739186 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

117 6.51 0 3 1050.0571 -1.52 27.04 2099.10698

SSILVHK LNX2 ligand of Numb protein X 2 [Homo sapiens]

222484 NP_699202 1 1 24025688 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

115 6.79 0 3 1004.5058 9.48 16.28 2008.00432

SSLSVPYVIVPLK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 24 1 115298678 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

111 7.4 0 3 1566.1559 2.02 48.55 3131.30449

SSMSETTVGVVCR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C12(Methylthio)

109 10.18 0 3 1021.5155 -0.7 58.74 3062.52463

SSNLIILEEHLK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 141 1 62739186 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

108 6.01 0 3 1228.6248 -5.12 31.31 2456.2529

SSNNPHSPIVEEFQVPYNK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 12 1 41393602 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

106 5.61 0 2 869.46149 0.97 47.59 1737.91435

SSPPWFIVDRPFLFFIR SERPINE2 glia-derived nexin isoform b precursor [Homo sapiens]

5270 NP_001130000 1 3 211904152 N-Term(iTRAQ4plex) 105 6.39 0 3 1141.6021 0.91 46.95 2282.19682

SSPVVIDASTAIDAPSNLR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

31 5 47132549;16933542

N-Term(iTRAQ4plex) 103 6.25 0 2 932.41669 0.9 23.05 1863.83245

SSQESYAHGTK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 8 1 62739186 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

103 7.28 0 2 1244.1561 3.58 30.19 2487.30498

SSSGILSMVFYTDSAIAK NRP1 neuropilin-1 isoform c precursor [Homo sapiens]

8829 NP_001019800 3 5 66864913 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

102 8.89 0 3 1029.8977 -1.45 33.3 3087.67856

SSSGLTYIAEWK MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 4 1 24497519 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

101 4.39 0 2 1203.1659 1.84 48.25 2421.31572

SSSLLIPPLETALANFSSGPEGGVMQPVR

CRYM thiomorpholine-carboxylate dehydrogenase isoform 1 [Homo sapiens]

1428 NP_001879 1 1 4503065 N-Term(iTRAQ4plex); M25(Oxidation)

101 8.9 0 3 1447.7699 6.33 23.14 2894.52042

SSSNEEVMFLTVQVK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 13 1 66932947 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

99 10.82 0 3 847.40009 -1.02 14.78 2540.1857

SSSPELSEMLEYDR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex) 97 6.56 0 3 1035.5851 5.98 55.59 2070.16289

SSTGPGEQLR COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 1 1 40217843 N-Term(iTRAQ4plex) 97 7.05 0 3 1237.5538 1.96 20.47 2474.09781

SSTSPTTNVLLSPLSVATALSALSLGAEQR

SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 8 1 39725934 N-Term(iTRAQ4plex) 95 6.05 0 2 930.4436 -5.47 32.48 1859.87993

SSVAAMHWMDGSVVTR PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 4 2 4506121 N-Term(iTRAQ4plex) 94 6.98 0 3 1334.7401 1.88 59.33 2668.47441

SSVAAMHWMDGSVVTR PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 6 2 4506121 N-Term(iTRAQ4plex); M6(Oxidation)

91 5.98 0 2 1011.0826 2.83 36.29 2021.15483

SSVITLNTNAELFNQSDIVAHLLSSSSSVIDALQYK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K36(iTRAQ4plex)

90 4.87 0 3 803.45105 1.21 35.76 1605.89482

STAAMSTYTGIFTDQVLSVLK

APOC2 apolipoprotein C-II precursor [Homo sapiens]

344 NP_000474 14 1 32130518 N-Term(iTRAQ4plex); M5(Oxidation); K21(iTRAQ4plex)

88 7.47 1 3 1382.255 0.28 37.59 2763.49143

STAAMSTYTGIFTDQVLSVLK

APOC2 apolipoprotein C-II precursor [Homo sapiens]

344 NP_000474 2 1 32130518 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

86 9.02 0 3 1379.5737 0.66 44.95 2758.13578

STATISGLKPGVDYTITVYAVTGR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

20 5 47132549;16933542

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

84 7.74 0 3 946.16614 3.09 39.14 2836.48185

STEATLSFGYLDPFPPEERPEVR

CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 4 3 28373119 N-Term(iTRAQ4plex) 83 5.1 0 2 790.9375 -6.15 30.76 1580.87053

STELCGLWQGR LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 4 1 4557892 N-Term(iTRAQ4plex); C5(Methylthio)

83 5.73 0 2 790.46613 -3.06 43.22 1579.92497

STEQDSRR SPATA13 spermatogenesis-associated protein 13 isoform 1 [Homo sapiens]

221178 NP_001159743 1 1 261337188 N-Term(iTRAQ4plex) 79 5.02 0 3 976.50873 1.69 37.44 1952.0112

STGGAPTFNVTVTK PFN1 profilin-1 [Homo sapiens] 5216 NP_005013 2 1 4826898 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

79 7.27 0 3 1264.2972 2.72 55.69 3790.88413

STGSWSTLK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 5 1 67782358 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

78 6.49 0 3 1036.0769 0.38 47.12 2071.15171

STISAEK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 2 1 5031695 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

76 5.01 0 3 887.49005 -0.03 29.64 1773.96823

STMQELNSR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 4 2 55956899 N-Term(iTRAQ4plex) 76 5.06 0 2 916.48749 -0.18 26.84 1831.97075

STMQELNSR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 1 2 55956899 N-Term(iTRAQ4plex); M3(Oxidation)

75 7.33 0 3 1379.7645 -0.44 44.22 2758.52178

STQDTVIALDALSAYWIASHTTEER

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

252 6 178557739;67190748

N-Term(iTRAQ4plex) 73 5.14 0 3 916.51367 2.41 22.12 1832.01633

STSIVIMLTDGDANVGESRPEK

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 34 1 133925809 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

73 5.7 0 3 1308.5786 -0.26 56.64 2616.15671

STSIVIMLTDGDANVGESRPEK

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 4 1 133925809 N-Term(iTRAQ4plex); M7(Oxidation); K22(iTRAQ4plex)

73 7.81 0 3 825.38873 -2.2 44.09 2474.15165

STSPPK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 7 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

72 7.74 0 3 1062.9036 1.4 66.85 3186.69614

STSSFSCLSR KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 4 2 47132620 N-Term(iTRAQ4plex); C7(Methylthio)

70 6.53 0 4 1516.6736 1.32 49.7 4548.00747

STTDNDIALLHLAQPATLSQTIVPICLPDSGLAER

PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 5 1 4506115 N-Term(iTRAQ4plex); C26(Methylthio)

70 9.97 1 5 1601.736 4.91 49.65 4803.17884

STTPDITGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex) 69 4.77 0 2 882.36255 0.76 67.72 1763.71404

STVISYECCPGYEK TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex); C8(Methylthio); C9(Methylthio); K14(iTRAQ4plex)

68 5.25 0 3 917.35706 -4.71 17.46 1833.72269

STVLTIPEIIIK F13A1 coagulation factor XIII A chain precursor [Homo sapiens]

2162 NP_000120 3 1 119395709 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

68 5.34 0 2 1131.1292 0 39.35 2261.25102

STYAQGTTVAPSAAPATRPAGDQQSVSK

LRRN4 leucine-rich repeat neuronal protein 4 precursor [Homo sapiens]

164312 NP_689824 1 1 188536110 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

68 5.55 0 2 957.42761 -1.02 65.89 1913.85442

SVAVYGQYGGQPCVGNAFETQSCEPTR

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 9 1 45580688 N-Term(iTRAQ4plex); C13(Methylthio); C23(Methylthio)

65 5.11 0 2 792.86615 0.91 46.91 1584.72502

SVENTGPLEDHNWPQYFR MEP1A meprin A subunit alpha precursor [Homo sapiens]

4224 NP_005579 2 1 153070262 N-Term(iTRAQ4plex) 64 4.2 0 3 515.92767 0.36 16.15 1545.76847

SVGFHLPSR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex) 64 6.59 0 2 1229.5441 1.98 28.24 2458.07475

SVLGQLGITK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 13 1 189163538 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

63 4.04 0 2 1338.7384 0.22 55.12 2676.46953

SVLRPSQFGGQPCTAPLVAFQPCIPSK

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 19 1 169636415 N-Term(iTRAQ4plex); C13(Methylthio); C23(Methylthio); K27(iTRAQ4plex)

63 4.59 0 3 976.50873 1.69 37.44 1968.0051

SVMAPFTMTIDAHTNGNGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); M3(Oxidation); K19(iTRAQ4plex)

63 4.3 0 2 680.388 -5.53 27.32 1359.76872

SVNDLYIQK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 21 1 73858566 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

62 4.89 0 3 539.59387 -0.7 55.48 1616.76909

SVNNVVVR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 2 3 21450863 N-Term(iTRAQ4plex) 62 8 1 3 954.18457 -0.57 31.01 2860.53916

SVPGCEGVALVVAQTK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

6 1 154146262 N-Term(iTRAQ4plex); C5(Methylthio); K16(iTRAQ4plex)

62 6.46 0 3 591.94556 2.42 54.33 1773.82541

SVPMVPPGIK LUM lumican precursor [Homo sapiens] 4060 NP_002336 9 1 4505047 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

60 4.27 0 3 683.87781 -6.27 15.57 1366.75147

Page 37: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

SVPMVPPGIK LUM lumican precursor [Homo sapiens] 4060 NP_002336 5 1 4505047 N-Term(iTRAQ4plex); M4(Oxidation); K10(iTRAQ4plex)

56 2.82 0 2 547.80847 1.1 16.46 1094.60442

SVPPSASHVAPTETFTYEWTVPK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 236 1 4557485 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

55 6.66 1 3 703.06421 1.44 38.45 2107.17807

SVQLTEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 10 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

54 8.54 0 3 1379.5737 0.66 44.95 2742.14188

SVSDGIAALDLNAVANK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 46 1 105990532 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

54 3.92 0 2 500.60312 -1.79 39.43 1499.79692

SVSEINPTTQMK KNG1 kininogen-1 isoform 2 precursor [Homo sapiens]

3827 NP_000884 2 1 156231037 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

53 3.9 0 2 648.33228 2.92 35.15 1295.65361

SVSLPSLDPASAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 12 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

52 4.24 0 2 677.79504 -4.43 20.31 1354.5855

SVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPR

LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 2 1 31652249 N-Term(iTRAQ4plex) 52 6.04 0 3 882.5144 -0.7 10.7 1764.02579

SVTEQGAELSNEER YWHAZ 14-3-3 protein zeta/delta [Homo sapiens]

7534 NP_003397 4 1 4507953 N-Term(iTRAQ4plex) 49 3.63 0 3 498.59995 -1.11 37.84 1493.78459

SVVLIPLGAVDDGEHSQNEK

CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 9 1 21071039 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

48 3.27 0 2 522.81726 -1.87 12.89 1044.62724

SWFEPLVEDMQR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 12 1 4557325 N-Term(iTRAQ4plex); M10(Oxidation)

47 4.56 0 3 734.41101 -0.12 12.68 1467.81589

SWFEPLVEDMQR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 5 1 4557325 N-Term(iTRAQ4plex) 45 2.91 0 2 501.77094 0.92 23.41 1002.53392

SWITPCPEEK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 10 1 29171717 N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

45 0 2 467.79498 1.63 8.81 934.58269

SWLAELQQWLKPGLK CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 23 1 4557417 N-Term(iTRAQ4plex); K11(iTRAQ4plex); K15(iTRAQ4plex)

45 3.69 0 2 882.36255 0.76 67.72 1779.70903

SWPAVGNCSSALR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 9 1 11321561 N-Term(iTRAQ4plex); C8(Methylthio)

43 5.17 0 2 870.45697 -6.81 20.08 1739.90666

SWSWGETGADTLRMDGTIMVPAFGHLEGWMLAGNRPR

LOC100509860

PREDICTED: hypothetical protein LOC100509860 [Homo sapiens]

100509860 XP_003119864 1 1 310113841 N-Term(iTRAQ4plex); M30(Oxidation)

42 5.74 1 4 1016.5204 -1.03 55.2 4063.05971

SWVPHTFESELSDPVELLVAES

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 48 1 21071030 N-Term(iTRAQ4plex) 40 3 0 2 548.35199 -4.49 23.88 1095.68559

SWWGDYWEPFR F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex) 38 0 2 648.33228 2.92 35.15 1311.64787

SWYLEDNINK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 11 1 105990535 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

37 0 2 545.2821 7.37 10.34 1089.55693

SYDWSQITTVATFGK CTBS di-N-acetylchitobiase precursor [Homo sapiens]

1486 NP_004379 2 1 4758092 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

37 8.34 0 4 1018.5086 4.1 47.05 4070.99062

SYELPDGQVITIGNER ACTB;ACTG2

actin, cytoplasmic 1 [Homo sapiens];actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

60;72 NP_001092;NP_001606

6 10 4501885;4501889

N-Term(iTRAQ4plex) 36 2.85 0 2 545.2821 7.37 10.34 1073.54851

SYFEK APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 3 1 4502149 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

36 8.21 0 6 1407.6928 2.4 48.04 5627.7467

SYFPESWLWEVHLVPR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 120 2 38016947 N-Term(iTRAQ4plex) 35 2.92 0 2 463.26477 -0.11 12.96 925.52226

SYLSMVGSCCTSASPTVCFLK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 172 2 32483410 N-Term(iTRAQ4plex); C9(Methylthio); C10(Methylthio); C18(Methylthio); K21(iTRAQ4plex)

35 4.17 0 2 627.83197 9.56 28.29 1254.64543

SYLSMVGSCCTSASPTVCFLK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 20 2 32483410 N-Term(iTRAQ4plex); M5(Oxidation); C9(Methylthio); C10(Methylthio); C18(Methylthio); K21(iTRAQ4plex)

33 3.06 0 2 659.8736 3.13 11.11 1318.73992

SYPEILTLK ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 2 3 91823602 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

33 2.8 0 2 534.27765 2.05 38.63 1067.54802

SYQWK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 1 1 355594753 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

33 0 2 452.29132 1.05 31.92 903.57536

SYSCQVTHEGSTVEK IGLL5 immunoglobulin lambda-like polypeptide 5 isoform 2 [Homo sapiens]

100423062 NP_001243225 4 2 372466586 N-Term(iTRAQ4plex); C4(Methylthio); K15(iTRAQ4plex)

32 3.21 0 2 508.79181 0.52 13.06 1016.57634

SYTITGLQPGTDYK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

19 5 47132549;16933542

N-Term(iTRAQ4plex); K14(iTRAQ4plex)

28 4.56 0 3 671.80865 -1.64 10.78 1342.61597

SYTVAIAGYALAQMGR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 244 1 115298678 N-Term(iTRAQ4plex) 28 0 2 521.21393 -0.43 8.38 1041.42058

SYTVAIAGYALAQMGR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 13 1 115298678 N-Term(iTRAQ4plex); M14(Oxidation)

18 3.09 0 2 646.24438 -2.6 43.91 1291.48149

SYYWIGIR SELL L-selectin precursor [Homo sapiens] 6402 NP_000646 4 1 262206315 N-Term(iTRAQ4plex) 5.36 0 5 1018.5086 4.1 47.05 4086.99079

TAAENDFVTLK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 4 2 47132620 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

4.61 0 3 525.95422 -2 19.91 1575.84812

TAAISGYSFK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 7 1 4503627 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

3.87 0 3 451.58664 3.03 11.5 1352.74536

TAAQNLYEK APOC2 apolipoprotein C-II precursor [Homo sapiens]

344 NP_000474 4 1 32130518 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

3.53 0 3 521.94513 3.21 15.76 1563.82083

TAECPGPAQNASPLVLPP FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 8 1 58331240 N-Term(iTRAQ4plex); C4(Methylthio)

3.43 0 3 627.34326 1.91 17.75 1880.01523

TAEYDVAYGESHLFR COL6A1 collagen alpha-1(VI) chain precursor [Homo sapiens]

1291 NP_001839 2 1 87196339 N-Term(iTRAQ4plex) 2.89 0 2 509.75717 -0.35 10.24 1018.50707

TAFDEAIAELDTLSEESYK YWHAZ 14-3-3 protein zeta/delta [Homo sapiens]

7534 NP_003397 2 1 4507953 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

2.8 0 2 575.30371 -12.29 20.28 1149.60015

TAFISDFAVTADGNAFIGDIK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 265 1 156119625 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

2.8 0 2 476.77011 -0.33 12.46 952.53295

TAFYLAEFFVNEAR GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 4 1 4503987 N-Term(iTRAQ4plex) 1.079 5 64.8 0.922 5 19.5 0.666 5 20.3 0.775 5 37.9 1.429 5 126 0.862 5 39.1 1.161 5 5.8 111 6.18 0 2 943.42896 0.01 24.55 1885.85063

TAGQGPGQLQR TGFBR3 transforming growth factor beta receptor type 3 isoform b precursor [Homo sapiens]

7049 NP_001182613 2 2 307574634 N-Term(iTRAQ4plex) 0.679 1 0.878 1 0.543 1 0.619 1 0.732 1 0.834 1 1.348 1 105 5.88 0 2 743.38043 -0.04 11.21 1485.75359

TAGSRSSHGGGWQMETEPSR

SIM2 single-minded homolog 2 short isoform [Homo sapiens]

6493 NP_033664 1 1 194239684 N-Term(iTRAQ4plex) 0.835 10 17.6 0.971 10 6.9 0.7 10 17.2 0.739 10 28.5 0.931 10 10.6 0.941 10 11.7 1.349 10 10.6 96 5.55 0 2 699.85901 0.93 16.28 1398.71294

TAGYGINILGMDPLSTPFDNEFYNGLCNR

C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 4 1 4502511 N-Term(iTRAQ4plex); M11(Oxidation); C27(Methylthio)

0.687 6 15.6 1.069 6 17.1 0.672 6 15.3 0.642 6 13.3 0.795 6 24.2 0.713 6 12 1.183 6 3.3 93 5.94 0 2 830.45795 -4.22 38.14 1659.91203

TAGYGINILGMDPLSTPFDNEFYNGLCNR

C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 17 1 4502511 N-Term(iTRAQ4plex); C27(Methylthio)

1.355 3 40.9 0.913 3 26.1 1.184 3 86.9 1.543 3 4.6 1.211 3 35.8 1.577 3 2.8 1.022 3 1.8 85 7.49 0 3 848.3797 1.53 34.44 2543.12455

TALQHLHGVPQGALLEDNR INHBC inhibin beta C chain preproprotein [Homo sapiens]

3626 NP_005529 2 1 5031795 N-Term(iTRAQ4plex) 0.609 2 3.9 1.064 2 25.4 0.558 2 10.8 0.524 2 14.3 0.703 2 7.5 0.661 2 17.6 1.26 2 3.2 81 5.25 0 2 748.91388 0.37 21.54 1496.82048

TAMDVFVCTYFMPAAQLPELPDVELPTNK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 5 2 32483410 N-Term(iTRAQ4plex); C8(Methylthio); K29(iTRAQ4plex)

1.172 3 6.3 0.98 3 7.2 1.187 3 5.6 1.094 3 24.5 1.371 3 4.7 1.274 3 25.8 1.155 3 0.8 80 5.93 0 3 661.67657 -0.71 53.1 1983.01517

TAMDVFVCTYFMPAAQLPELPDVELPTNK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 22 2 32483410 N-Term(iTRAQ4plex); M3(Oxidation); C8(Methylthio); K29(iTRAQ4plex)

0.798 1 0.861 1 0.708 1 0.822 1 0.776 1 0.901 1 1.097 1 74 7.99 0 3 1070.2022 0.17 46.62 3208.59189

TAMDVFVCTYFMPAAQLPELPDVELPTNK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 2 2 32483410 N-Term(iTRAQ4plex); M3(Oxidation); C8(Methylthio); M12(Oxidation); K29(iTRAQ4plex)

0.642 4 11.9 1.05 4 22 0.541 4 15.7 0.561 4 7.1 0.725 4 16.2 0.731 4 16.5 1.303 4 10.7 73 4.93 0 2 714.37238 -4.79 23.17 1427.74077

TASFGNILDVPEIVISGNGQPRR

MAP3K7 mitogen-activated protein kinase kinase kinase 7 isoform C [Homo sapiens]

6885 NP_663305 1 2 21735564 N-Term(iTRAQ4plex) 0.841 8 12.5 0.988 8 7.5 0.708 8 11.8 0.681 8 10 0.957 8 14.4 1.042 8 9.2 1.394 8 18 71 5.71 0 3 875.00342 -2.38 50.79 1749.0084

TASTPTPDDK CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 10 1 4503011 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.902 1 1.027 1 0.88 1 0.857 1 0.949 1 0.924 1 1.078 1 67 4.15 0 3 626.30109 0.6 9.69 1876.88871

TATITVLPQQPR AXL tyrosine-protein kinase receptor UFO isoform 2 precursor [Homo sapiens]

558 NP_001690 2 2 21536468 N-Term(iTRAQ4plex) 0.473 1 1.304 1 0.426 1 0.327 1 0.663 1 0.508 1 1.555 1 61 4.08 0 2 678.85956 3.42 17.33 1356.71184

TATMLCAASGNPDPEITWFK

PTPRS receptor-type tyrosine-protein phosphatase S isoform 2 precursor [Homo sapiens]

5802 NP_570924 1 10 104487297 N-Term(iTRAQ4plex); C6(Methylthio); K20(iTRAQ4plex)

0.704 3 10.3 0.885 3 15.2 0.543 3 34.2 0.629 3 3.8 0.756 3 12.3 0.869 3 15 1.282 3 9.5 60 4.55 0 3 491.91937 1.43 33.54 1473.74089

TATSEYQTFFNPR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 16 1 4503635 N-Term(iTRAQ4plex) 0.726 2 7.3 1.059 2 1.8 0.641 2 5.8 0.605 2 4 0.855 2 10 0.807 2 8.2 1.334 2 4.1 56 4.07 0 2 669.36517 3.65 34.28 1337.72307

TAVTANLDIR CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 N-Term(iTRAQ4plex) 0.648 2 13.6 0.985 2 19.1 0.576 2 8.7 0.584 2 28.1 0.713 2 0.5 0.724 2 19.6 1.239 2 8.2 50 3.73 0 2 632.79321 0.71 37.73 1264.57915

TCAQEGMVLYGWTDHSACSPVCPAGMEYR

VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); C2(Methylthio); C18(Methylthio); C22(Methylthio)

1.472 1 1.091 1 1.243 1 1.139 1 1.836 1 1.682 1 1.477 1 49 5.03 0 3 628.94086 0.17 20.91 1884.80802

TCENFR PPIG peptidyl-prolyl cis-trans isomerase G [Homo sapiens]

9360 NP_004783 1 1 42560244 N-Term(iTRAQ4plex); C2(Methylthio)

3.792 2 1886.3 1.074 2 54.7 2.653 2 1931.1 2.469 2 7659.7 5.262 2 763.1 4.897 2 2465.2 1.984 2 43.2 45 7.02 0 4 1095.8245 -0.22 70.18 4380.27602

TCESLGAGGYR HSPG2 basement membrane-specific heparan sulfate proteoglycan core protein precursor [Homo sapiens]

3339 NP_005520 2 1 126012571 N-Term(iTRAQ4plex); C2(Methylthio)

0.721 1 0.715 1 0.517 1 0.723 1 0.72 1 1.007 1 1.394 1 44 3.19 0 2 678.85956 3.42 17.33 1372.69585

TCIMNNGVGYR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); C2(Methylthio)

1.411 1 0.608 1 0.852 1 1.4 1 1.417 1 2.33 1 1.664 1 43 5.2 0 4 902.48553 -0.85 72.58 3606.92031

TCPKPDDLPFSTVVPLK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 175 1 153266841 N-Term(iTRAQ4plex); C2(Methylthio); K4(iTRAQ4plex); K17(iTRAQ4plex)

0.639 2 17.1 1.005 2 2.9 0.595 2 23.2 0.592 2 20.2 0.686 2 14.7 0.683 2 11.8 1.154 2 8.3 41 3.34 0 2 591.31903 2.1 22.75 1181.63078

TCQDINECETTNECR EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor [Homo sapiens]

2202 NP_001034437 2 1 86788015 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); C14(Methylthio)

0.969 2 20.6 0.969 2 12.1 0.878 2 15.8 0.905 2 28.3 1.032 2 13.6 1.064 2 26 1.176 2 2.2 31 3.53 0 3 732.84662 0.67 13.79 1464.6879

TCQGSCAALSGLTGCTTR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C2(Methylthio); C6(Methylthio); C15(Methylthio)

0.725 2 4.1 1.218 2 3.7 0.729 2 15.6 0.599 2 11.8 0.868 2 17 0.713 2 20.8 1.19 2 33.2 5.26 1 4 941.51117 -0.44 64.15 3763.02285

TCQSLHINEMCQER VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C2(Methylthio); C11(Methylthio)

0.543 2 9.8 0.857 2 23.4 0.465 2 13.7 0.543 2 9.5 0.542 2 10 0.633 2 34 1.165 2 24 5.17 1 4 941.51117 -0.44 64.15 3747.03188

TDAPDLPEENQAR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 19 2 38016947 N-Term(iTRAQ4plex) 1.484 1 1.154 1 1.698 1 1.471 1 1.499 1 1.299 1 0.883 1 4.05 0 4 1070.2022 0.17 46.62 3192.58413

TDASDVKPC APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 6 1 153266841 N-Term(iTRAQ4plex); K7(iTRAQ4plex); C9(Methylthio)

90 6.24 0 2 882.49799 -0.43 21.92 1763.9904

TDCLSLPSFENAIPMGEK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 10 1 62739186 N-Term(iTRAQ4plex); C3(Methylthio); M15(Oxidation); K18(iTRAQ4plex)

1.029 4 6.1 1.024 4 10.2 0.991 4 8 0.956 4 18 1.229 4 16.2 1.117 4 10.9 1.233 4 5.3 88 5.25 0 2 778.39111 -5.4 17.6 1555.78691

TDCLSLPSFENAIPMGEK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 44 1 62739186 N-Term(iTRAQ4plex); C3(Methylthio); K18(iTRAQ4plex)

1.302 3 6.5 0.924 3 16.7 1.173 3 18.7 1.27 3 2 1.332 3 11.2 1.441 3 5.4 1.135 3 7.4 66 5.7 0 3 1120.1028 3.08 59.96 2239.20078

TDCPGDALFDLLR PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 23 1 156616294 N-Term(iTRAQ4plex); C3(Methylthio)

1.25 2 8.1 0.933 2 4.2 1.141 2 13.5 1.223 2 9.3 1.274 2 7 1.365 2 2.8 1.116 2 6.5 65 5.67 0 2 1030.5106 3.09 17.43 2060.01396

TDELPQLVTLPHPNLHGPEILDVPSTVQK

FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 6 3 16933542 N-Term(iTRAQ4plex); K29(iTRAQ4plex)

1.483 1 0.878 1 1.304 1 1.486 1 1.48 1 1.687 1 1.135 1 3.49 0 3 1120.1028 3.08 59.96 2255.19907

TDGAAPNVAPSDVGGGGGR

CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 2 2 28373119 N-Term(iTRAQ4plex) 1.609 1 0.869 1 1.417 1 1.632 1 1.589 1 1.829 1 1.121 1 32 0 2 558.86292 -4.07 23.81 1116.71855

TDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNK

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 17 1 21071030 N-Term(iTRAQ4plex); K42(iTRAQ4plex)

1.227 1 0.936 1 1.411 1 1.508 1 0.965 1 1.031 1 0.684 1 35 4.31 0 4 1110.056 1.44 76.48 4437.20229

TDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNK

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 4 1 21071030 N-Term(iTRAQ4plex); M28(Oxidation); K42(iTRAQ4plex)

1.35 1 0.915 1 1.181 1 1.29 1 1.405 1 1.535 1 1.189 1 34 3.65 0 2 777.86847 -0.58 42.64 1554.72966

TDLHAFENLEIIR EGFR epidermal growth factor receptor isoform b precursor [Homo sapiens]

1956 NP_958439 2 3 41327732 N-Term(iTRAQ4plex) 1.281 1 1.019 1 1.095 1 1.075 1 1.49 1 1.463 1 1.36 1 62 4.39 0 3 667.38043 0.02 48.25 2000.12674

TDMELEVLR PEPD xaa-Pro dipeptidase isoform 1 [Homo sapiens]

5184 NP_000276 NP_116041

2 2 149589008 N-Term(iTRAQ4plex) 1.178 1 0.897 1 1.038 1 1.158 1 1.196 1 1.333 1 1.152 1 2.92 0 2 553.26727 -1.68 49.6 1105.52727

TEAPSATGQASSLLGGR COL18A1 collagen alpha-1(XVIII) chain isoform 2 precursor [Homo sapiens]

80781 NP_569712 2 2 110611233 N-Term(iTRAQ4plex) 1.267 1 0.915 1 1.126 1 1.231 1 1.299 1 1.421 1 1.154 1 2.81 0 2 487.27829 5.95 23.93 973.5493

TECFITGWGETQGTFGAGLLK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 193 1 4505881 N-Term(iTRAQ4plex); C3(Methylthio); K21(iTRAQ4plex)

0.994 1 0.985 1 0.917 1 0.931 1 1.055 1 1.071 1 1.15 1 105 5.76 0 2 996.5174 -2.11 44.46 1992.02751

TECIKPVVQEVLTITPFQR C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 5 1 169636415 N-Term(iTRAQ4plex); C3(Methylthio); K5(iTRAQ4plex)

1.12 1 0.913 1 0.984 1 1.078 1 1.159 1 1.269 1 1.177 1 60 3.76 0 2 1039.5706 1.03 27.78 2078.13384

TEDSSSFLIDK SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 22 1 205277441 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.092 2 8.5 0.969 2 17.4 1.009 2 14.4 1.041 2 3 1.145 2 19.5 1.181 2 2.1 1.135 2 5.1 57 3.21 0 2 547.74615 0.96 22.64 1094.48503

TEDTIFLR ORM2;ORM1

alpha-1-acid glycoprotein 2 precursor [Homo sapiens];alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5005;5004 NP_000599;NP_000598

2 2 4505529;167857790

N-Term(iTRAQ4plex) 1.383 1 0.997 1 1.288 1 1.291 1 1.475 1 1.479 1 1.145 1 54 7.7 0 3 876.43811 -9.43 28.8 2627.29978

TEESPSAPDAPTCPK PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 4 1 157653329 N-Term(iTRAQ4plex); C13(Methylthio); K15(iTRAQ4plex)

1.079 12 2.8 0.8 12 14.4 0.902 12 12 1.044 12 12.4 1.087 12 10.2 1.272 12 11.2 1.176 12 13 109 9.04 0 3 843.13873 0.59 76.8 2527.40146

TEGDGVYTLNDK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 15 2 4826762 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.002 7 5.2 1.021 7 9 0.96 7 7.9 0.98 7 7.8 1.046 7 9.2 1.068 7 8.4 1.089 7 0.9 69 7.41 0 3 978.54462 -1.97 59.52 1956.08713

TEGDGVYTLNNEK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 28 2 4826762 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.252 1 0.741 1 0.958 1 1.293 1 1.222 1 1.649 1 1.276 1 62 5.52 0 3 830.78857 -0.22 44.94 2490.35117

TEGQFVDLTGNR MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 8 1 4557739 N-Term(iTRAQ4plex) 0.954 4 3.1 0.911 4 3.6 0.886 4 11.6 0.941 4 8 0.999 4 7.7 1.087 4 8.5 1.125 4 7.7 58 4.66 0 2 670.29657 0.52 27.97 1339.58537

TEHGSEMLFFGNAIEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); M7(Oxidation); K17(iTRAQ4plex)

1.269 1 0.841 1 0.939 1 1.117 1 1.398 1 1.662 1 1.488 1 58 4.86 0 3 830.78857 -0.22 44.94 2506.3425

TEHGSEMLFFGNAIEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.04 2 25.6 1.119 2 9.8 1.029 2 16.7 0.92 2 26.8 1.175 2 23.3 1.05 2 33.7 1.142 2 6.5 57 4.02 0 2 684.86548 3.83 20.61 1368.72368

TEHPFTVEEFVLPK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 19 1 66932947 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.132 2 19.1 0.988 2 5.9 1.119 2 32.8 1.132 2 39.3 1.118 2 0.1 1.132 2 5.9 1 2 32.9 42 7.81 0 3 902.7558 -0.1 45.09 2706.25284

TEHYEEQIEAFK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 16 1 4502511 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.943 2 3.6 0.836 2 11.5 0.811 2 6.5 0.97 2 5 0.922 2 10.9 1.103 2 0.5 1.137 2 4.4 37 3.27 0 2 575.34167 1.06 35.91 1149.67156

TEIDKPSQMQVTDVQDNSISVK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

79 5 47132549;16933542

N-Term(iTRAQ4plex); K5(iTRAQ4plex); K22(iTRAQ4plex)

1.296 1 1.341 1 1.521 1 1.135 1 1.512 1 1.128 1 0.994 1 8.16 0 4 904.2616 1.59 73.69 3614.02456

TELLPGDRDNLAIQTR IGFBP7 insulin-like growth factor-binding protein 7 isoform 2 precursor [Homo sapiens]

3490 NP_001240764 1 2 359465608 N-Term(iTRAQ4plex) 2.269 1 0.989 1 2.132 1 2.156 1 2.381 1 2.407 1 1.117 1 2.81 1 2 1001.0048 -7.12 24.82 2001.00237

TELRPGETLNVNFLLR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 29 1 115298678 N-Term(iTRAQ4plex) 0.984 1 0.884 1 0.877 1 0.992 1 0.978 1 1.106 1 1.115 1 83 6.02 0 2 826.95648 -2.5 36.58 1652.90569

TENLNDDEK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 1 167614506 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.233 6 6.6 0.968 6 5.4 2.12 6 8.4 2.111 6 1 2.333 6 8.8 2.373 6 3.4 1.122 6 2.8 32 0 2 473.28854 5.32 19.71 945.56468

TEQAAVAR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 5 1 145275213 N-Term(iTRAQ4plex) 1.089 1 0.82 1 0.865 1 1.054 1 1.117 1 1.362 1 1.291 1 59 4.05 0 2 741.86481 -0.24 23.14 1482.72234

TEQWSTLPPETK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

78 6 178557739;67190748

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.19 1 0.796 1 0.988 1 1.241 1 1.148 1 1.442 1 1.162 1 49 0 2 602.86426 2.67 35.98 1204.72124

TESCPDGAR PAPLN papilin precursor [Homo sapiens] 89932 NP_775733 XP_370765

2 1 145309328 N-Term(iTRAQ4plex); C4(Methylthio)

0.828 1 0.936 1 0.747 1 0.798 1 0.856 1 0.915 1 1.146 1 62 4.12 0 2 720.38416 -0.07 24.85 1439.76103

TESIIHR SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 2 1 39725934 N-Term(iTRAQ4plex) 1.311 1 0.986 1 1.219 1 1.236 1 1.385 1 1.405 1 1.137 1 46 4.27 0 3 769.4024 -3.05 40.12 2306.19266

TETITGFQVDAVPANGQTPIQR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex) 14.632 22 101.5 0.825 22 18.4 12.328 22 115.9 14.093 22 212.1 11.19 22 172.1 13.737 22 271.7 1.102 22 22.6 124 9.47 0 3 1384.618 -0.25 71.87 4151.83957

TEVIPPLIENR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 11 1 105990532 N-Term(iTRAQ4plex) 5.331 71 79.7 0.964 71 13 5.083 71 80.1 5.247 71 80.2 5.84 71 79.6 6.011 71 83.4 1.114 72 3.5 102 5.87 0 2 811.91095 -0.9 31.49 1622.81218

TEVNVLPGAK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 4 1 70778918 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

17.874 15 37.2 1.001 15 24.1 14.82 15 41 18.333 15 58.4 16.811 15 51 20.344 15 53.9 1.11 15 2.6 93 5.66 0 2 864.42822 -11.51 16.62 1727.88457

TEVSSNHVLIYLDK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 5 1 66932947 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

17.61 9 51.4 0.903 9 11.3 15.172 9 53.3 17.124 9 43.9 17.182 9 54.9 19.562 9 44.5 1.139 9 2.8 92 5.45 0 2 800.41315 5.34 16.63 1599.79814

TFAHYATFR FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 3 2 27754776 N-Term(iTRAQ4plex) 8.423 13 85 0.915 12 25.9 8.133 12 84.3 10.977 13 78.3 9.045 12 73.3 11.379 13 100.8 1.123 13 8.7 90 4.65 0 2 789.96979 -1.43 33.92 1578.93425

TFAPEEISAMVLTK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 4 1 16507237 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

9.981 28 104.3 0.922 28 8.1 8.145 28 132.8 9.659 28 104.6 9.735 28 128.9 11.031 28 115.6 1.109 28 4.1 88 4.98 0 2 746.42456 0.57 33.36 1491.85588

TFDSSCHFFATK SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 1 1 4507171 N-Term(iTRAQ4plex); C6(Methylthio); K12(iTRAQ4plex)

8.014 8 127.5 0.961 8 29.3 4.674 7 103 5.741 8 177.4 5.245 7 87.8 5.89 8 123 1.132 8 5.6 81 7.73 0 3 695.07861 2.81 33.85 2083.21817

TFGSGEADCGLRPLFEK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 35 1 4503635 N-Term(iTRAQ4plex); C9(Methylthio); K17(iTRAQ4plex)

13.217 10 43.1 1.043 10 57.1 12.914 10 62.1 12.991 10 25.4 15.106 10 53.7 14.864 10 25.5 1.176 11 6.6 79 8.5 0 3 817.08234 1.78 39.48 2449.23246

TFHEASEDCISR CLEC3B tetranectin precursor [Homo sapiens]

7123 NP_003269 8 1 156627579 N-Term(iTRAQ4plex); C9(Methylthio)

7.198 5 22 0.972 5 11.9 6.678 5 17.3 5.902 5 55 8.299 5 36.6 7.647 5 28.9 1.109 5 5.5 73 5.21 0 3 619.63135 -1.68 45.1 1856.88315

TFIEDVNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

7.546 7 79.4 0.966 7 15.8 7.742 7 94.1 6.495 7 83.7 8.799 7 89 7.382 7 93.1 1.137 7 6.2 73 4.88 0 3 619.63135 -1.68 45.1 1840.89676

TFISPIK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 6 1 115298678 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

13.024 10 116.8 0.839 8 17.6 8.407 8 69.9 12.551 10 55.4 9.58 8 61.8 14.086 10 66.6 1.148 12 11.5 65 8.34 0 5 1614.7664 13.27 31.09 3228.51575

TFPGFFSPMLGEFVSETESR

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 12 2 4503689 N-Term(iTRAQ4plex); M9(Oxidation)

8.171 8 61.9 0.964 8 10 7.16 8 57.1 8.105 8 59.5 8.232 8 60.5 9.319 8 59.4 1.145 8 2.4 61 4.32 0 3 899.4574 -1.16 29.47 1797.90451

Page 38: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

TFPGFFSPMLGEFVSETESR

FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 2 2 4503689 N-Term(iTRAQ4plex) 17.193 6 122.1 0.742 6 43.7 14.129 6 83.9 17.303 5 78.3 14.308 6 100 17.405 5 81.1 1.046 7 5.9 59 7.5 0 3 817.08234 1.78 39.48 2465.2161

TFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); M23(Oxidation); K32(iTRAQ4plex)

3.04 48 31.3 0.806 48 14.1 2.544 48 32.4 3.37 48 36.9 2.939 48 36.5 3.767 48 35.3 1.124 48 5.6 57 3.47 0 2 661.36456 -5.02 35.38 1321.72844

TFSEWLESVK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 25 1 169636415 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

11.45 4 57.6 0.799 4 8 10.592 4 58.8 11.11 4 39.3 11.771 4 59.3 12.448 4 35.6 1.12 4 4.2 54 3.08 0 2 573.85266 0.67 16.25 1146.6812

TFTLLDPK PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 1 1 156616294 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

9.099 2 141.6 0.882 2 24.4 7.983 2 125 9.051 2 182.4 9.193 2 113 10.424 2 165.2 1.152 2 6.3 50 3.64 0 2 717.87787 1.2 12.42 1434.74834

TFTPQPPGLER IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 8 2 4826772 N-Term(iTRAQ4plex) 5.113 18 62.1 0.924 18 12.1 4.69 18 76.6 4.902 18 54.4 5.303 18 71.6 5.586 18 60.6 1.114 18 4.2 45 3.39 0 2 562.80334 2.2 19.89 1124.59502

TFVLNFIK PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 14 1 4506115 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

7.426 5 26.1 1.372 5 312.5 18.265 6 285.6 5.237 5 221.3 17.086 5 227.5 6.976 5 134.2 1.138 8 28.5 43 7.45 1 6 1281.6272 8.71 29.33 3842.86974

TFVNITPAEVGVLVGK PFN1 profilin-1 [Homo sapiens] 5216 NP_005013 6 1 4826898 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

6.427 18 166.9 0.917 18 9.4 5.829 18 155.8 6.149 18 154.5 6.691 18 168.4 7.059 18 173 1.12 18 2.7 42 3.83 0 2 604.83844 2.45 30.08 1208.6696

TFVPGCQPGEFTLGNIK LCN2 neutrophil gelatinase-associated lipocalin precursor [Homo sapiens]

3934 NP_005555 2 1 38455402 N-Term(iTRAQ4plex); C6(Methylthio); K17(iTRAQ4plex)

8.418 1 0.895 1 7.306 1 8.162 1 8.648 1 9.661 1 1.184 1 37 3.43 0 3 404.58514 4.8 15.59 1211.74088

TFYEPGEEITYSCKPGYVSR APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 107 1 153266841 N-Term(iTRAQ4plex); C13(Methylthio); K14(iTRAQ4plex)

12.722 6 65.6 0.825 6 13.5 10.972 6 62.2 13.205 6 74.7 12.364 6 57.8 14.88 6 70 1.13 6 2.1 35 2.77 0 2 477.24426 0.36 22.28 953.48058

TFYSCTTEGR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

14 6 47132549;16933542

N-Term(iTRAQ4plex); C5(Methylthio)

9.513 1 0.821 1 8.302 1 10.116 1 9.019 1 10.989 1 1.086 1 34 3.59 1 2 1206.6466 10.5 28.72 2412.28594

TGCSLMGASVDSTLAFNTYVHFQGK

AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 24 1 4557287 N-Term(iTRAQ4plex); C3(Methylthio); K25(iTRAQ4plex)

4.396 1 0.945 1 4.102 1 4.341 1 4.448 1 4.708 1 1.084 1 32 0 2 424.24124 -0.26 12.36 847.47521

TGCSLMGASVDSTLAFNTYVHFQGK

AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 4 1 4557287 N-Term(iTRAQ4plex); C3(Methylthio); M6(Oxidation); K25(iTRAQ4plex)

16.224 1 1.088 1 15.644 1 14.384 1 18.226 1 16.759 1 1.165 1 32 0 2 524.80182 -6.3 15.81 1048.59636

TGDEITYQCR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 35 2 62739186 N-Term(iTRAQ4plex); C9(Methylthio)

6.73 3 10.6 1.056 3 7.1 6.665 3 21.6 6.017 3 5.4 7.519 3 16.6 6.788 3 0.5 1.128 3 4.3 32 0 2 441.25793 0.29 10.25 881.50847

TGDIVEFVCK CFHR2 complement factor H-related protein 2 precursor [Homo sapiens]

3080 NP_005657 33 1 5031695 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

7.33 1 0.784 1 6.365 1 8.115 1 6.714 1 8.56 1 1.055 1 3.82 1 4 427.49118 -0.51 10.44 1706.94289

TGDTIEFMCK CFHR3;CFHR4

complement factor H-related protein 3 isoform 2 precursor [Homo sapiens];complement factor H-related protein 4 isoform 3 precursor [Homo sapiens]

10878;10877

NP_001160096;NP_006675

6 5 262231791;117320518

N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

1.082 14 13.9 0.851 14 24.9 1.068 14 12.7 1.145 14 13.1 1.108 14 18.1 1.204 14 15.5 1.076 14 9.7 125 8.17 0 3 1178.1478 -0.78 47 2355.28838

TGDTIEFMCK CFHR3;CFHR4

complement factor H-related protein 3 isoform 2 precursor [Homo sapiens];complement factor H-related protein 4 isoform 3 precursor [Homo sapiens]

10878;10877

NP_001160096;NP_006675

1 5 262231791;117320518

N-Term(iTRAQ4plex); M8(Oxidation); C9(Methylthio); K10(iTRAQ4plex)

1.023 9 14.3 0.893 9 20.5 0.967 9 9.3 0.977 9 12.6 1.145 9 26 1.118 9 3.6 1.208 9 9.1 108 9.75 0 3 1393.2534 0.73 48.37 2785.49956

TGEAVAEK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 17 2 38016947 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.02 6 3.8 0.987 6 7.8 0.983 6 6.1 1.014 6 6.1 1.106 6 13.6 1.106 6 10.6 1.133 6 6.8 98 5.8 0 3 872.04297 0.85 51.38 1743.07706

TGEAVAEKDSEITFIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 3 2 38016947 N-Term(iTRAQ4plex); K8(iTRAQ4plex); K16(iTRAQ4plex)

0.788 14 25.7 1 14 23.3 0.771 14 24 0.776 14 27.1 0.766 14 30.3 0.821 14 24.4 1.13 14 6.8 92 4.87 0 3 1055.994 -0.86 64.86 2110.98264

TGESAEFVCK CFHR1 complement factor H-related protein 1 precursor [Homo sapiens]

3078 NP_002104 17 1 118442839 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

0.975 9 12.8 0.918 9 20.2 0.879 9 14.9 0.99 9 14 0.996 9 17.5 1.065 9 6 1.072 9 13.4 82 6.06 0 2 908.03064 2.35 63.38 1815.05022

TGESVEFVCK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 59 1 62739186 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

0.987 8 8 0.901 8 9.3 0.911 8 13.4 0.971 8 11.2 1.011 8 9.2 1.097 8 11.8 1.114 8 4.2 76 4.74 0 3 804.48248 -1.55 58.13 1607.95456

TGISPLALIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 29 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.021 4 8.6 0.971 4 3.7 0.918 4 9.2 0.982 4 11.3 1.058 4 5.3 1.076 4 7.2 1.127 4 7 76 5.12 0 3 804.47046 6.12 35.11 1607.92783

TGIVSGFGR F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 3 1 4503625 N-Term(iTRAQ4plex) 0.958 6 3.8 0.899 6 3.7 0.847 6 8.3 0.948 6 7.5 0.956 6 3.2 1.06 6 4 1.118 6 5 71 5.42 0 2 953.55402 4.63 56.12 1906.10076

TGLDSPTGIDFSDITANSFTVHWIAPR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

14 5 47132549;16933542

N-Term(iTRAQ4plex) 1.018 4 4.1 0.915 4 11.8 0.938 4 12.1 1.021 4 7 0.972 4 10.6 1.035 4 6.6 1.099 4 7 68 6.85 0 4 622.32556 -8.87 32.18 1864.99599

TGLLLLSDPDK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

33 2 31542984;262050538

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.977 2 7.5 1.02 2 6.1 0.831 2 26.3 0.814 2 32.7 1.128 2 11.4 1.106 2 5.3 1.358 2 38.6 60 4.41 0 2 729.89734 3.56 34.06 1458.7874

TGLLLLSDPDKVTIGLLFWDGR

ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

48 2 31542984;262050538

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.95 4 9 0.907 4 2.1 0.839 4 11.6 0.938 4 12.6 0.961 4 5.7 1.063 4 7.5 1.122 4 3.1 55 5.45 0 4 806.42102 8.15 21.08 1611.83571

TGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFR

FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 4 1 47132549 N-Term(iTRAQ4plex); C26(Methylthio)

0.949 3 3.6 0.978 3 0.4 0.929 3 1.8 0.838 3 20.8 0.982 3 13.1 0.968 3 5.8 1.155 3 1.4 49 5.29 0 3 463.58069 5.99 22.25 1388.71186

TGRNASIHTLLDALERMEER TNFRSF10A tumor necrosis factor receptor superfamily member 10A [Homo sapiens]

8797 NP_003835 1 1 259906438 N-Term(iTRAQ4plex) 0.986 10 6.5 0.994 10 7 0.92 10 12.8 0.916 10 2.4 1.037 10 9 1.04 10 5 1.11 10 4.6 45 3.72 0 3 396.57141 -1.75 39.65 1187.70439

TGVITSPDFPNPYPK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

10 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.014 3 7.4 0.952 3 11.4 0.903 3 8.7 0.931 3 14.7 1.099 3 0.1 1.069 3 23.7 1.148 3 8.7 44 0 2 640.28265 0.96 44.86 1279.55803

TGYYFDGISR FBLN1;FBLN1

fibulin-1 isoform D precursor [Homo sapiens];fibulin-1 isoform D precursor [Homo sapiens]

2192;2192 NP_006477;NP_006477

6 4 34734066;34734062

N-Term(iTRAQ4plex) 1.019 5 6.7 0.904 5 12.5 0.882 5 13.2 0.976 5 4.4 1.031 5 14.6 1.079 5 4.3 1.112 5 7.1 44 3.62 0 2 693.88062 2.97 32.59 1386.75395

THEDLYIIPIPNCDR IGFBP4 insulin-like growth factor-binding protein 4 precursor [Homo sapiens]

3487 NP_001543 5 1 62243290 N-Term(iTRAQ4plex); C13(Methylthio)

0.983 2 8.9 0.824 2 35.6 0.834 2 25.4 1.012 2 9.5 0.972 2 24.3 1.18 2 10.6 1.166 2 1.1 43 2.92 0 2 525.83344 4.36 23.5 1050.64141

THLPEVFLSK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 17 2 32483410 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.002 2 7.9 0.93 2 34.1 0.901 2 23.8 0.969 2 9.7 1.045 2 24.5 1.123 2 9 1.159 2 0.7 36 3.18 0 2 508.30869 8.26 26.62 1015.61009

THNLEPYFESFINNLR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 14 2 119395750 N-Term(iTRAQ4plex) 0.738 1 1.097 1 0.713 1 0.649 1 0.836 1 0.762 1 1.173 1 4.08 1 3 680.08154 -0.14 73.17 2038.23008

THNLEPYFESFINNLRR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 2 2 119395750 N-Term(iTRAQ4plex) 0.996 5 3 0.944 5 3.5 0.882 5 4.7 0.96 5 4 1.015 5 3.6 1.112 5 2.2 1.159 5 3.4 3.19 0 2 575.85162 0.62 51.78 1150.69597

THYYAVAVVK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 2 2 312433998 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.685 1 0.996 1 0.646 1 0.649 1 0.722 1 0.725 1 1.117 1 106 5.25 0 2 834.46033 -4.39 20.34 1667.91338

TIAYENK LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 2 1 5031863 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.757 3 6.8 0.777 3 10 0.603 3 5.9 0.785 3 1.6 0.742 3 13.9 0.921 3 5.4 1.153 3 9.6 96 6.27 0 3 966.57123 -2.96 59.75 1932.14426

TICESSGIWSNPSPICQK SELL L-selectin precursor [Homo sapiens] 6402 NP_000646 2 1 262206315 N-Term(iTRAQ4plex); C3(Methylthio); C16(Methylthio); K18(iTRAQ4plex)

0.615 2 19.2 0.974 2 11.5 0.542 2 13.4 0.556 2 1.8 0.671 2 34.9 0.689 2 22.8 1.238 2 20.9 33 3.17 0 2 581.87634 -1.56 31.73 1162.74541

TIDDLKNQILNLTTDNANILLQIDNAR

KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

2 2 195972866 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.682 1 0.904 1 1.481 1 1.638 1 1.723 1 1.905 1 1.163 1 3.51 0 3 639.66425 -7.03 48.58 1916.97818

TIDQMLNSELQWPVPDIYLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 14 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation)

1.4 14 10.4 1.025 14 13.1 1.27 14 8.9 1.266 14 9.1 1.514 14 11.8 1.464 14 14.9 1.156 14 7.2 91 5.36 0 3 994.46478 -2.58 61.4 1987.92229

TIDQMLNSELQWPVPDIYLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex) 1.443 13 8.8 1.027 13 19.5 1.371 13 12.4 1.301 13 11.7 1.575 13 15.7 1.477 13 10.1 1.135 13 6.4 75 5.42 0 2 876.92737 -3.71 30.65 1752.84783

TIESILEPVAQQISHLVIMHEEGEVDGK

VCL vinculin isoform VCL [Homo sapiens]

7414 NP_003364 2 2 4507877 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.46 19 11.5 0.968 19 7.2 1.398 19 16 1.422 19 11.5 1.555 19 15.6 1.562 19 8.2 1.104 19 8.7 66 4.74 0 2 722.87384 -1.02 44.98 1444.73747

TIFFCER CDH1 cadherin-1 preproprotein [Homo sapiens]

999 NP_004351 1 1 4757960 N-Term(iTRAQ4plex); C5(Methylthio)

1.298 9 7.6 0.943 9 19.2 1.135 9 22.5 1.247 9 3.8 1.353 9 17.5 1.43 9 6.1 1.176 9 2.9 51 3.45 0 2 701.34766 -8.29 23.62 1401.68804

TIHDLHLFIENIDFNK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 31 1 105990532 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.453 1 1.106 1 1.44 1 1.302 1 1.62 1 1.465 1 1.125 1 42 2.95 0 2 512.2995 -0.73 9.91 1023.59172

TIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQK

AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 5 1 4557287 N-Term(iTRAQ4plex); M6(Oxidation); K38(iTRAQ4plex)

1.508 1 1.134 1 1.502 1 1.324 1 1.717 1 1.514 1 1.143 1 29 0 2 543.26019 -1.23 12.83 1085.51311

TIHSEQAVFDIYYPTEQVTIQVLPPK

ALCAM CD166 antigen isoform 3 precursor [Homo sapiens]

214 NP_001230210 2 3 343168772 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.297 1 0.883 1 1.142 1 1.294 1 1.3 1 1.472 1 1.138 1 28 0 3 994.46478 -2.58 61.4 2003.9271

TILDANEEFKSMSGTIQLGR BNIP1 vesicle transport protein SEC20 isoform BNIP1-a [Homo sapiens]

662 NP_053581 1 4 153946403 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.623 1 1.036 1 1.538 1 1.484 1 1.768 1 1.706 1 1.15 1 52 3.83 0 2 601.88202 -2.6 33.48 1202.75676

TILDDLR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 25 1 70778918 N-Term(iTRAQ4plex) 1.198 1 0.808 1 1.162 1 1.438 1 1.004 1 1.243 1 0.864 1 48 5.46 0 3 738.39819 -4.87 20.69 2213.18003

TILDDLRAEDHFSVIDFNQNIR

ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 15 1 70778918 N-Term(iTRAQ4plex) 1.125 1 0.835 1 0.972 1 1.164 1 1.093 1 1.309 1 1.124 1 65 3.93 0 2 712.90289 0.46 27.12 1424.79851

TILGTMPAFEVSLQALQK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 92 1 105990532 N-Term(iTRAQ4plex); M6(Oxidation); K18(iTRAQ4plex)

1.157 2 11.9 0.955 2 5.2 1.043 2 21 1.092 2 15.6 1.219 2 8.9 1.275 2 3.7 1.168 2 11.9 62 7.81 0 3 688.05676 -0.45 55.35 2062.15573

TILGTMPAFEVSLQALQK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

2.024 1 0.834 1 1.746 1 2.094 1 1.966 1 2.358 1 1.126 1 2.83 2 2 1089.6033 -5.92 28.77 2178.19927

TILSDDWK CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 1 2 28373119 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.672 2 1.7 0.939 2 23.3 0.597 2 13 0.636 2 10.1 0.71 2 12.9 0.757 2 10.2 1.19 2 0.2 72 4.78 0 2 735.37805 -4.13 37.42 1469.74883

TINPAVDHCCK AFM afamin precursor [Homo sapiens] 173 NP_001124 6 1 4501987 N-Term(iTRAQ4plex); C9(Methylthio); C10(Methylthio); K11(iTRAQ4plex)

0.577 1 0.97 1 0.496 1 0.511 1 0.64 1 0.66 1 1.291 1 66 5.06 0 2 776.41107 0.84 40.08 1551.81487

TINVPLR C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 1 1 87298828 N-Term(iTRAQ4plex) 0.577 2 2.6 0.919 2 8.5 0.491 2 2.8 0.535 2 5.7 0.616 2 9.8 0.671 2 1.2 1.255 2 7 55 4.25 0 2 655.34595 -1.73 20.06 1309.68462

TITLEVEPSDTIENVK UBB polyubiquitin-B precursor [Homo sapiens]

7314 NP_061828 2 4 11024714 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.984 1 0.964 1 0.887 1 0.921 1 1.044 1 1.084 1 1.177 1 45 2.87 0 2 578.81189 7.43 26.33 1156.6165

TIVTTLQDSIR THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 12 1 40317626 N-Term(iTRAQ4plex) 55 6.4 1 3 902.82343 0.15 76.67 2706.45572

TIYTPGSTVLYR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 23 1 115298678 N-Term(iTRAQ4plex) 44 3.57 0 2 626.33118 8.04 26.08 1251.64739

TKEEYGHSEVVEYYCNPR CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 40 1 62739186 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C15(Methylthio)

0.846 2 12.3 0.933 2 4.6 0.797 2 11.9 0.855 2 16.6 0.838 2 8.3 0.899 2 12.9 1.051 2 3.6 76 6.25 0 3 1064.6033 -2.04 48.38 2128.20005

TKPYIQVDIGGGQTK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 4 1 16507237 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K15(iTRAQ4plex)

0.849 2 11 0.874 2 2.4 0.743 2 9.9 0.851 2 12.3 0.849 2 10 0.971 2 12.3 1.142 2 0.1 75 5.13 0 3 579.63452 -2.65 58.94 1736.88933

TKTETITGFQVDAVPANGQTPIQR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

6 5 47132549;16933542

N-Term(iTRAQ4plex); K2(iTRAQ4plex)

0.7 1 0.893 1 0.675 1 0.756 1 0.649 1 0.727 1 0.962 1 72 3.34 0 2 602.31372 0.23 19.49 1203.62016

TLADLTLLDSPIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 47 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.951 3 11.7 0.793 3 3.4 0.738 3 6 1.008 3 15.5 0.985 3 3.2 1.214 3 6.7 1.113 3 4.6 60 4.42 0 3 548.66522 -0.7 54.34 1643.98111

TLAFPLTIR PROCR endothelial protein C receptor precursor [Homo sapiens]

10544 NP_006395 2 1 34335272 N-Term(iTRAQ4plex) 0.75 1 1.067 1 0.709 1 0.665 1 0.842 1 0.789 1 1.187 1 59 3.78 0 2 871.89026 -2.65 23.92 1742.77324

TLDEFTIIQNLQPQYQFR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

20 1 66347875 N-Term(iTRAQ4plex) 0.927 1 0.782 1 0.694 1 0.888 1 0.958 1 1.225 1 1.38 1 53 5.58 0 3 538.96021 5.13 16.59 1614.86606

TLDLGENQLETLPPDLLR LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 32 1 16418467 N-Term(iTRAQ4plex) 0.952 1 0.937 1 0.849 1 0.906 1 0.994 1 1.061 1 1.171 1 38 3.32 0 2 563.8194 -2.79 13.17 1126.63152

TLDPER C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex) 1.349 2 51.1 0.984 2 9.2 1.259 2 56.5 1.28 2 45.6 1.419 2 56.7 1.443 2 45.8 1.127 2 0.2 32 3.23 0 2 675.83167 0.09 26.03 1350.65007

TLEAQLTPR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 19 1 73858566 N-Term(iTRAQ4plex) 1.414 1 1.178 1 1.451 1 1.231 1 1.63 1 1.384 1 1.123 1 4.2 2 4 884.92249 6.2 48.21 3536.66811

TLEGPVPLEVIVIDQNDNRPIFR

CDH13 cadherin-13 isoform 3 precursor [Homo sapiens]

1012 NP_001207418 6 3 333944018 N-Term(iTRAQ4plex) 0.898 1 0.945 1 0.83 1 0.878 1 0.917 1 0.971 1 1.105 1 35 3.34 0 2 558.80377 7.52 25.77 1116.60027

TLEIPGNSDPNMIPDGDFNSYVR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

15 6 178557739;67190748

N-Term(iTRAQ4plex) 2.073 249 25.9 0.886 247 24.3 1.783 249 31.5 2.135 247 23.2 1.992 249 33.2 2.42 247 22.9 1.14 249 11.2 138 7.67 0 3 1098.5884 2.54 72.39 2196.15726

TLEIPGNSDPNMIPDGDFNSYVR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

10 6 178557739;67190748

N-Term(iTRAQ4plex); M12(Oxidation)

2.045 75 14.9 0.911 75 19.3 1.811 75 19.8 2.028 75 13.5 2.07 75 22.1 2.35 75 19.8 1.137 75 13.2 121 9.9 0 3 1257.1649 -2.14 52.07 2513.32256

TLGARERTQDLAPLEK TCHHL1 trichohyalin-like protein 1 [Homo sapiens]

126637 NP_001008536 XP_060104

1 1 56606114 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

2.164 242 15.3 0.983 242 19.2 2.028 242 23.9 2.069 242 18.8 2.338 242 20.1 2.318 242 17.4 1.131 242 8.1 117 6.97 0 3 1090.5365 -4.28 36.27 2180.07181

TLGAWGSLCNSHWDIEDAHVLCQQLK

CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 1 2 344179112 N-Term(iTRAQ4plex); C9(Methylthio); C22(Methylthio); K26(iTRAQ4plex)

2.435 151 39.4 0.92 151 16 2.216 151 41.8 2.378 151 39.4 2.462 151 40.9 2.617 151 46 1.128 151 12.2 103 7.16 0 3 1184.6188 5.53 73.8 2368.23027

TLGDQLSLLLGAR MRC2 C-type mannose receptor 2 precursor [Homo sapiens]

9902 NP_006030 2 1 110624774 N-Term(iTRAQ4plex) 2.177 116 23.3 0.952 116 19.8 1.966 116 27.8 1.976 116 35 2.334 116 21.9 2.262 116 35.6 1.161 116 11.9 102 8.4 0 3 1292.6952 3.16 78.53 2584.3831

TLLDIDNTR KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 2 2 55956899 N-Term(iTRAQ4plex) 2.012 97 22.5 0.964 97 18.6 1.842 97 29.8 1.969 97 23.2 2.14 97 26.5 2.255 97 24.2 1.122 97 7.4 94 5.22 0 2 961.01709 0.19 65.94 1921.02628

TLLEGEESR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 2 2 119395750 N-Term(iTRAQ4plex) 2.346 25 10.1 0.885 25 13.8 2.026 25 13.6 2.36 25 12.9 2.358 25 14.5 2.652 25 12.2 1.136 25 10.9 93 7 0 3 1184.6188 5.53 73.8 2352.22336

TLLETLQK PCYOX1 prenylcysteine oxidase 1 precursor [Homo sapiens]

51449 NP_057381 2 1 166795301 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.995 113 14.5 0.991 113 12 1.804 113 20.5 1.899 113 14.3 2.052 113 21.2 2.148 113 14.3 1.127 113 5.4 91 6.14 0 2 849.92719 -3.65 50.97 1698.85417

TLLLVGSPTWK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 4 1 29171717 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

3.489 31 32.4 0.939 31 17.2 3.089 31 31.9 3.454 31 28.1 3.517 31 31.1 3.865 31 33.8 1.126 31 7.1 88 6.96 0 3 1184.6188 5.53 73.8 2384.21636

TLLPVSKPEIR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 8 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.114 155 11.3 0.956 155 8.9 1.95 155 13.3 2.06 155 11.8 2.18 155 13.4 2.312 155 12.3 1.118 155 4.7 79 4.54 0 3 453.94925 0.26 47.58 1359.83013

TLLSNLEEAK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 54 1 355594753 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.972 15 20.6 0.946 15 12.6 1.822 15 17.6 1.973 15 20.3 1.949 15 18.8 2.374 15 15 1.143 15 4.8 78 6.22 0 3 691.92462 4.43 16.56 1382.83867

TLLSNLEEAKK CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 8 1 355594753 N-Term(iTRAQ4plex); K10(iTRAQ4plex); K11(iTRAQ4plex)

2.671 1 0.722 1 2.206 1 3.056 1 2.392 1 3.315 1 1.085 1 75 6.65 0 3 845.08759 -1.4 43.9 2533.2482

TLLVEAEGIEQEK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 5 1 162809334 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.314 18 42.8 0.958 18 9 2.135 18 51.6 2.15 18 42 2.511 18 51.3 2.532 18 37.4 1.138 18 6.5 75 4.63 0 3 961.01709 0.19 65.94 1937.01763

TLLVFEVQQPFLFVLWDQQHK

SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 12 1 73858568 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

2.808 3 20.6 0.353 3 10.8 2.836 3 63.6 5.418 3 147.2 2.255 3 26.9 5.339 3 235.2 0.849 3 9.9 73 7.64 1 4 1175.9623 1.21 80.28 3525.87978

TLLVFEVQQPFLFVLWDQQHKFPVFMGR

SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 1 1 73858568 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.897 65 10.4 0.791 65 13.1 1.623 65 12.3 2.071 65 16 1.767 65 10.6 2.298 65 16 1.099 65 7.2 72 6.1 0 3 639.96088 0.52 57.28 1917.86808

TLMFGSYLDDEK ORM2 alpha-1-acid glycoprotein 2 precursor [Homo sapiens]

5005 NP_000599 2 1 4505529 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.697 1 1.098 1 1.648 1 1.501 1 1.913 1 1.743 1 1.161 1 70 6.2 0 3 845.08759 -1.4 43.9 2501.25309

TLMNLGGLAVAR TAGLN2 transgelin-2 [Homo sapiens] 8407 NP_003555 1 1 4507357 N-Term(iTRAQ4plex) 2.058 46 11.7 0.984 46 9.8 1.889 46 12.3 1.984 46 15.2 2.146 46 12 2.201 46 12.9 1.11 46 4.8 67 3.96 0 2 552.81488 8.58 29.56 1104.61162TLNICEVGTIR C6 complement component C6

precursor [Homo sapiens]729 NP_000056 25 1 169636415 N-Term(iTRAQ4plex);

C5(Methylthio)1.914 185 20.7 0.917 185 29.6 1.669 185 28.2 1.829 185 29.4 2.018 185 28 2.152 185 31.4 1.138 185 18 66 7.61 0 3 983.20099 2.26 67.36 2947.58841

TLNLAQNLLAQLPEELFHPLTSLQTLK

CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

15 1 256217721 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

2.721 16 33.2 0.768 16 21.1 2.306 16 33.1 2.864 16 35.1 2.439 16 35.6 3.019 16 37.6 1.133 16 3.8 61 5.39 0 3 639.96088 0.52 57.28 1933.85967

TLNQSSDELQLSMGNAMFVK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 2 1 50659080 N-Term(iTRAQ4plex); M13(Oxidation); M17(Oxidation); K20(iTRAQ4plex)

1.923 85 26.7 0.947 84 29.5 1.77 85 31.6 1.818 84 43.4 1.896 85 30.3 1.954 84 40.6 1.078 85 26.5 59 7.98 0 4 983.20099 2.26 67.36 2963.58634

TLNQSSDELQLSMGNAMFVK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 2 1 50659080 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

2.138 225 10.5 0.971 225 9.8 1.981 225 11.1 2.038 225 11.8 2.249 225 11.3 2.318 225 11.7 1.126 225 5.2 57 3.67 0 3 450.60132 -1.86 30 1349.7896

TLPECSK AFM afamin precursor [Homo sapiens] 173 NP_001124 1 1 4501987 N-Term(iTRAQ4plex); C5(Methylthio); K7(iTRAQ4plex)

1.937 13 9.5 0.9 13 11.8 1.792 13 14.8 1.875 13 19.9 2.01 13 13.7 2.13 13 13.9 1.113 13 3.8 56 7.09 0 4 1209.6262 1.88 50.43 2418.24516

TLPPGLLTPTPK GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 4 1 291190772 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.593 21 17.2 0.875 21 12 1.373 21 18.5 1.581 21 14.1 1.541 21 16.6 1.793 21 6.2 1.11 21 9.5 56 7.59 0 3 1209.6262 1.88 50.43 2402.25444

TLQALEFHTVPFQLLAR LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 4 1 5031863 N-Term(iTRAQ4plex) 2.006 6 17.3 0.968 6 6.6 2.039 6 30 2.145 6 12.2 1.887 6 8.4 2.016 6 6.9 0.971 6 15.3 55 7.2 0 4 983.20099 2.26 67.36 2979.57705

TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSR

ASB2 ankyrin repeat and SOCS box protein 2 isoform 2 [Homo sapiens]

51676 NP_057234 1 2 18252778 N-Term(iTRAQ4plex); C13(Methylthio); C19(Methylthio); K35(iTRAQ4plex)

2.305 96 5.8 1.019 96 6.6 2.196 96 6.2 2.161 96 7.1 2.438 96 8.2 2.423 96 7.4 1.117 96 3.2 55 3.25 0 2 576.84955 4.44 19.81 1152.68645

TLQELK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.696 5 6.2 0.904 5 13.1 1.302 5 29.5 1.661 5 7.5 1.722 5 6.9 1.837 5 10.6 1.141 5 9.8 52 6.05 1 3 693.04767 0.38 45.51 2077.12845

TLQGIPQMIGEVIR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex) 1.439 3 13.4 1.034 3 0.5 1.324 3 1 1.35 3 8 1.526 3 18.1 1.567 3 27.4 1.153 3 0.9 48 4.51 1 3 475.63339 1.33 16.79 1424.88562

TLQGIPQMIGEVIR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex); M8(Oxidation)

2.886 4 14.4 1.07 4 4.6 2.544 4 17.7 2.488 4 29.7 3.148 4 8.3 3.092 4 19.4 1.204 4 5.2 46 4.34 0 3 961.01709 0.19 65.94 1953.01096

TLQPGDGEASTPR MEGF8 multiple epidermal growth factor-like domains protein 8 precursor [Homo sapiens]

1954 NP_001401 XP_290821

2 1 145701025 N-Term(iTRAQ4plex) 2.275 41 15.6 0.795 41 16.5 1.882 41 11 2.464 41 18.6 2.166 41 11.1 2.777 41 17 1.142 41 4.1 44 0 2 495.82538 -0.3 83.85 990.6444

TLSDVLQYVK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 4 1 21264359 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.847 42 11.2 0.952 42 8 1.705 42 7.1 1.827 42 13.6 1.876 42 11.8 2.066 42 14.1 1.116 42 4 44 3.36 0 2 559.32007 -0.48 36.09 1117.63286

TLSDYNIQK UBB polyubiquitin-B precursor [Homo sapiens]

7314 NP_061828 4 4 11024714 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.423 3 5.9 0.859 3 5 2.06 3 8.3 2.301 3 2.2 2.532 3 9.2 2.828 3 3.1 1.229 3 1 43 5.09 1 3 693.04767 0.38 45.51 2093.11667

TLSLPELEQQQEQQQEQQQEQVQMLAPLES

APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 2 1 71773110 N-Term(iTRAQ4plex) 2.253 9 24.3 0.858 9 19.4 2.133 9 38.1 1.995 9 17.6 2.546 9 33 2.577 9 32.1 1.142 9 18.4 41 6.74 0 4 1209.6262 1.88 50.43 2434.24125

TLSLPELEQQQEQQQEQQQEQVQMLAPLES

APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 2 1 71773110 N-Term(iTRAQ4plex); M24(Oxidation)

2.17 17 8.4 0.871 17 33.9 1.868 17 26.6 2.174 17 9.5 2.197 17 14.4 2.434 17 13.6 1.13 17 4.5 35 0 2 499.77487 2.76 12.07 998.53795

TLSPVLESPR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 2 188528648 N-Term(iTRAQ4plex) 2.052 12 10.5 1.054 12 14.5 1.816 12 19.9 2.086 12 5.9 2.031 12 15.5 2.397 12 9.7 1.141 12 3.7 34 0 2 423.76849 1.15 8.95 846.52904

TLSQFPETLLGDREKR KCNA10 potassium voltage-gated channel subfamily A member 10 [Homo sapiens]

3744 NP_005540 1 1 5031819 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.797 1 0.69 1 1.349 1 1.954 1 1.689 1 2.447 1 1.252 1 32 4.47 1 4 566.02692 -6.81 21.53 2261.08584

TLTLALIWQLMRR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 1 1 167614506 N-Term(iTRAQ4plex) 2.26 2 3.3 1.039 2 51.9 2.004 2 19.2 1.929 2 30.5 2.66 2 36.3 2.561 2 13.7 1.328 2 16.2 31 9.03 1 4 854.729 4.2 57.96 3415.89419TLTSVSVFVDHHLAPSFYFVAFYYHGDHPVANSLR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

8 6 178557739;67190748

N-Term(iTRAQ4plex) 2.309 1 0.972 1 2.189 1 2.251 1 2.365 1 2.432 1 1.08 1 30 0 2 455.74207 1.93 17.32 910.47685

Page 39: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

TLVLLMGK PFN1 profilin-1 [Homo sapiens] 5216 NP_005013 3 1 4826898 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

3.467 1 0.222 1 2.154 1 9.685 1 2.084 1 9.374 1 0.968 1 30 4.2 1 3 1131.6316 1 81.03 3392.88022

TLVTQNSGVEALIHAILR JUP junction plakoglobin [Homo sapiens] 3728 NP_068831 2 1 12056468 N-Term(iTRAQ4plex) 1.374 2 6.7 1.139 2 45 1.371 2 29.3 1.203 2 14.3 1.599 2 31 1.404 2 12.6 1.167 2 1.6 6.66 1 5 535.69495 1.08 49.73 2674.44562

TLYLADTFPTNFR SERPINA5 plasma serine protease inhibitor precursor [Homo sapiens]

5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 2.136 5 35.6 1.021 5 15.8 2.341 5 39.5 2.007 5 19.9 2.179 5 40.2 2.311 5 11.1 1.123 5 14.1 6.54 2 5 708.99762 1.28 79.71 3540.95899

TLYSSSPR SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 8 1 73858568 N-Term(iTRAQ4plex) 1.828 3 16.2 0.973 3 18.6 1.8 3 13.7 2.044 3 3.7 1.599 3 0.5 1.861 3 19.1 0.97 3 13.1 6.5 1 5 535.69495 1.08 49.73 2690.43623

TLYVGAR SEMA4B semaphorin-4B precursor [Homo sapiens]

10509 NP_064595 1 1 39777608 N-Term(iTRAQ4plex) 1.911 1 1.081 1 1.513 1 1.4 1 2.463 1 2.279 1 1.627 1 4.94 2 4 861.21924 4.72 48.32 3441.85512

TMDPSCLK KAT7 histone acetyltransferase KAT7 isoform 5 [Homo sapiens]

11143 NP_001186087 1 5 312434017 N-Term(iTRAQ4plex); M2(Oxidation); C6(Methylthio); K8(iTRAQ4plex)

2.901 1 0.921 1 2.505 1 2.722 1 3.066 1 3.331 1 1.224 1 4.93 1 4 950.50494 1.8 75.46 3798.99795

TMEQFTIHLTVNPQSK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 11 1 156119625 N-Term(iTRAQ4plex); M2(Oxidation); K16(iTRAQ4plex)

1.814 1 0.837 1 1.598 1 1.91 1 1.734 1 2.072 1 1.085 1 3.85 1 3 610.38379 1.47 56.93 1829.13681

TMEQFTIHLTVNPQSK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 45 1 156119625 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.399 1 0.888 1 1.266 1 1.426 1 1.375 1 1.548 1 1.086 1 67 5.38 0 2 821.96594 0.06 44.62 1642.92461

TMFICK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 13 1 119392081 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

1.129 1 0.883 1 1.024 1 1.158 1 1.104 1 1.249 1 1.078 1 62 7.48 0 3 838.45349 -0.87 44.32 2513.34592

TMFIGGSQLSQK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 4 1 29171717 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.649 1 0.947 1 1.343 1 1.417 1 1.868 1 1.972 1 1.391 1 54 0 2 752.92377 -0.01 49.4 1504.84026

TMFIGGSQLSQK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 4 1 29171717 N-Term(iTRAQ4plex); M2(Oxidation); K12(iTRAQ4plex)

1.704 1 0.848 1 1.45 1 1.709 1 1.7 1 2.004 1 1.173 1 54 3.68 0 2 680.3905 -1.18 49.47 1359.77373

TMGYQDFADVVCYTQK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 47 1 119392081 N-Term(iTRAQ4plex); C12(Methylthio); K16(iTRAQ4plex)

1.532 1 0.714 1 1.228 1 1.72 1 1.398 1 1.959 1 1.139 1 41 0 2 1003.0308 1.05 80.73 2005.05425

TMGYQDFADVVCYTQK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 18 1 119392081 N-Term(iTRAQ4plex); M2(Oxidation); C12(Methylthio); K16(iTRAQ4plex)

1.466 1 0.91 1 1.246 1 1.369 1 1.555 1 1.708 1 1.248 1 39 5.06 0 3 793.06573 -2.27 54.39 2377.18265

TMLLQPAGSLGSYSYR PTGDS prostaglandin-H2 D-isomerase precursor [Homo sapiens]

5730 NP_000945 6 1 32171249 N-Term(iTRAQ4plex) 1.407 1 0.892 1 1.212 1 1.36 1 1.448 1 1.624 1 1.195 1 35 6.64 0 3 790.05151 -2.03 40.98 2368.13999

TMLLQPAGSLGSYSYR PTGDS prostaglandin-H2 D-isomerase precursor [Homo sapiens]

5730 NP_000945 4 1 32171249 N-Term(iTRAQ4plex); M2(Oxidation)

1.46 1 1.086 1 1.52 1 1.4 1 1.525 1 1.405 1 1.003 1 34 5.19 0 4 511.74457 1.31 48.88 2043.95644

TMQALPYSTVGNSNNYLHLSVLR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 10 1 115298678 N-Term(iTRAQ4plex) 1.264 1 0.932 1 1.157 1 1.241 1 1.285 1 1.379 1 1.111 1 34 0 2 541.79236 -0.99 37.16 1082.57744

TMQENSTPR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 10 1 41393602 N-Term(iTRAQ4plex) 1.143 1 1.026 1 1.1 1 1.072 1 1.215 1 1.184 1 1.104 1 27 0 2 393.77188 5.93 34.64 786.53649

TMQENSTPR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 1 1 41393602 N-Term(iTRAQ4plex); M2(Oxidation)

1.13 1 1.057 1 1.125 1 1.065 1 1.199 1 1.135 1 1.066 1 102 4.92 0 2 1241.1157 -0.12 32.32 2481.22417

TMQENSTPRED C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 4 1 41393602 N-Term(iTRAQ4plex) 1.042 2 9 1.097 2 7.3 1.005 2 15.7 0.916 2 8.4 1.181 2 10.3 1.076 2 3 1.175 2 5.3 90 6.1 0 2 957.44208 0.2 46.56 1913.87688

TMSGLECQAWDSQSPHAHGYIPSK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 14 1 4505881 N-Term(iTRAQ4plex); C7(Methylthio); K24(iTRAQ4plex)

1.157 3 3 0.868 3 8.9 1.062 3 11.7 1.299 3 4.3 1.207 3 3.9 1.298 3 2.8 1.068 3 12.8 85 6.26 0 3 935.37445 -2.82 20.19 1869.741

TMSGLECQAWDSQSPHAHGYIPSK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 8 1 4505881 N-Term(iTRAQ4plex); M2(Oxidation); C7(Methylthio); K24(iTRAQ4plex)

1.325 4 2.5 0.93 4 12.5 1.2 4 12.2 1.281 4 7.3 1.348 4 4.5 1.488 4 3.8 1.197 4 9.5 81 7.93 0 3 892.01965 0.31 49.64 2674.04441

TNAENEFVTIK KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 12 2 119395750 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.144 3 0.1 1.005 3 12 1.094 3 5.9 1.044 3 6.2 1.201 3 6.3 1.195 3 5.3 1.101 3 0.4 77 5.68 0 3 911.93756 -1.55 32.21 1822.86563

TNFDNDIALVR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 12 1 41393602 N-Term(iTRAQ4plex) 1.135 2 9.8 0.953 2 6.6 1.066 2 13.3 1.118 2 6.7 1.152 2 12.9 1.208 2 6.2 1.08 2 0.5 55 4.11 0 2 640.81396 -0.13 40.66 1280.61553

TNFWIGLFR LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 1 2 341915493 N-Term(iTRAQ4plex) 1.126 2 3.2 0.922 2 5.7 1.023 2 5.4 1.109 2 0.2 1.142 2 6.4 1.239 2 0.8 1.117 2 1 52 5.69 0 3 913.97046 0.99 29.71 1826.92929

TNIQVTVTGPSSPSPVK CD109 CD109 antigen isoform 3 precursor [Homo sapiens]

135228 NP_001153060 2 2 227430303 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.217 1 0.919 1 1.069 1 1.164 1 1.267 1 1.378 1 1.184 1 49 4.92 0 2 1099.0115 -1.43 43.97 2197.01567

TNLESILSYPK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 34 1 73858568 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.992 1 0.956 1 0.914 1 0.956 1 1.027 1 1.074 1 1.124 1 45 6.98 1 3 959.77527 2.48 44.75 2877.31125

TNPCLHGGR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 5 1 145275213 N-Term(iTRAQ4plex); C4(Methylthio)

1.014 1 0.862 1 0.901 1 1.045 1 0.987 1 1.145 1 1.096 1 31 0 2 499.74152 8.91 26.19 998.47576

TNQVNSGGVLLR C1QC complement C1q subcomponent subunit C precursor [Homo sapiens]

714 NP_001107573 3 1 166235903 N-Term(iTRAQ4plex) 1.876 1 0.845 1 1.81 1 2.142 1 1.652 1 1.955 1 0.913 1 4.01 0 3 796.33539 3.41 52.48 2386.99161

TNTGLALR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 1 1 89191868 N-Term(iTRAQ4plex) 1.175 2 4.3 0.906 2 6.3 1.064 2 6.5 1.175 2 0.2 1.176 2 8.1 1.298 2 1.7 1.105 2 1.6 2.83 0 2 530.30786 1.57 41.12 1059.60845

TNTNVNCPIECFMPLDVQADR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

7 5 47132549;16933542

N-Term(iTRAQ4plex); C7(Methylthio); C11(Methylthio)

1.257 1 1.022 1 1.265 1 1.238 1 1.276 1 1.249 1 1.009 1 60 4.81 0 2 951.47711 -0.25 33.35 1901.94695

TNYIGHK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 1 1 40317626 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.107 1 0.879 1 0.961 1 1.093 1 1.119 1 1.274 1 1.165 1 4.42 0 4 538.2876 -7.65 26.11 2150.12856

TPALHFK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.47 1 0.922 1 1.353 1 1.468 1 1.472 1 1.596 1 1.087 1 3.17 0 2 559.84332 -0.82 46.08 1118.67937

TPCQQELDQVLER IGFBP2 insulin-like growth factor-binding protein 2 precursor [Homo sapiens]

3485 NP_000588 4 1 55925576 N-Term(iTRAQ4plex); C3(Methylthio)

1.549 3 4.7 1.019 3 6.3 1.399 3 23.1 1.602 3 0.4 1.597 3 8.1 1.587 3 1.8 1.072 3 13.5 3.56 1 3 710.05811 11.56 77.52 2128.15976

TPCTVSCNIPVVSGK FGB fibrinogen beta chain isoform 1 preproprotein [Homo sapiens]

2244 NP_005132 2 2 70906435 N-Term(iTRAQ4plex); C3(Methylthio); C7(Methylthio); K15(iTRAQ4plex)

0.734 1 0.948 1 0.631 1 0.666 1 0.799 1 0.843 1 1.266 1 43 2.85 0 2 604.84247 1.7 33.59 1208.67766

TPDGSLLVR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

1 1 154146262 N-Term(iTRAQ4plex) 0.973 1 1.007 1 0.817 1 0.812 1 1.136 1 1.128 1 1.39 1 35 4.39 0 3 798.39832 2.08 57.63 2393.18039

TPEGLTLLFK DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 5 1 116534900 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

2.338 1 0.949 1 2.011 1 2.119 1 2.546 1 2.683 1 1.266 1 4.26 0 4 589.86676 -1.71 48.57 2356.44521

TPENFPCK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 15 1 4505881 N-Term(iTRAQ4plex); C7(Methylthio); K8(iTRAQ4plex)

0.98 1 0.871 1 0.828 1 0.95 1 1.006 1 1.155 1 1.215 1 2.85 0 2 567.32159 -4.04 12.37 1133.63591

TPENYPNAGLTMNYCR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 2 1 4505881 N-Term(iTRAQ4plex); C15(Methylthio)

1.13 2 2.9 0.946 2 30.3 1.136 2 17.4 1.201 2 12.4 1.072 2 5.4 1.133 2 24.6 0.943 2 11.9 6.3 0 3 908.15198 1.46 55.6 2722.44138

TPENYPNAGLTMNYCR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 6 1 4505881 N-Term(iTRAQ4plex); M12(Oxidation); C15(Methylthio)

1.39 2 8.1 0.864 2 24 1.274 2 14.3 1.475 2 9.4 1.324 2 24 1.533 2 0 1.04 2 9.4 64 5.5 0 3 986.51343 -3.58 47.48 1972.0217

TPESSPPGTPIGR CDH6 cadherin-6 preproprotein [Homo sapiens]

1004 NP_004923 2 1 4826673 N-Term(iTRAQ4plex) 1.481 1 1.045 1 1.357 1 1.298 1 1.673 1 1.6 1 1.233 1 37 4.72 1 3 944.13403 -3.9 29.87 2830.38755

TPFDYCALR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); C6(Methylthio)

1.257 6 8.8 0.748 6 16.9 1.258 6 20.8 1.495 6 10.8 1.085 6 6.7 1.418 6 25.1 0.949 6 5 5.05 1 4 873.17261 -9.11 50.39 3489.6686

TPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFR

FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 2 4 16933542 N-Term(iTRAQ4plex); M31(Oxidation)

1.465 1 0.786 1 1.267 1 1.612 1 1.349 1 1.715 1 1.064 1 3.58 1 3 891.75684 -7.56 55.8 2673.25595

TPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFR

FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 5 4 16933542 N-Term(iTRAQ4plex) 1.2 1 0.937 1 1.091 1 1.164 1 1.232 1 1.315 1 1.13 1 76 4.98 0 2 873.47498 -5.57 24.21 1745.94267

TPGAAANLELIFVGPQHAGNYR

A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 373 1 21071030 N-Term(iTRAQ4plex) 1.362 1 0.826 1 1.138 1 1.377 1 1.349 1 1.633 1 1.186 1 71 4.25 0 2 860.42572 -5 20.09 1719.84416

TPGIWLLHCHVTDHIHAGMETTYTVLQNEDTK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 10 1 4557485 N-Term(iTRAQ4plex); C9(Methylthio); K32(iTRAQ4plex)

1.123 1 0.927 1 1.034 1 1.116 1 1.13 1 1.22 1 1.093 1 58 5.18 0 2 938.50226 -0.05 64.51 1875.99724

TPLLSMSTYPSVPPEMAYGWMVEHKHR

ASH1L histone-lysine N-methyltransferase ASH1L [Homo sapiens]

55870 NP_060959 1 1 110349788 N-Term(iTRAQ4plex); M6(Oxidation); K25(iTRAQ4plex)

1.15 1 0.912 1 1.014 1 1.113 1 1.183 1 1.298 1 1.166 1 40 3.08 0 2 650.87152 -2.59 32.59 1300.73577

TPRPIIFLQPPWTTVFQGER FCRL5 Fc receptor-like protein 5 isoform 1 precursor [Homo sapiens]

83416 NP_112571 XP_001133405 XP_001134256

2 2 157694526 N-Term(iTRAQ4plex) 1.169 2 2 0.957 2 31.8 1.065 2 13.2 1.113 2 18 1.235 2 20.8 1.29 2 10.4 1.159 2 7.5 39 5.15 0 3 583.36115 0.89 37.02 1748.06888

TPSCGDICNFPPK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 11 1 4502503 N-Term(iTRAQ4plex); C4(Methylthio); C8(Methylthio); K13(iTRAQ4plex)

0.867 1 1.188 1 0.893 1 0.752 1 1.003 1 0.845 1 1.124 1 33 0 2 687.84015 -14.7 20.83 1374.67302

TQFNNNEYSQDLDAYNTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 31 1 105990532 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

0.986 1 0.943 1 0.938 1 0.995 1 0.978 1 1.037 1 1.043 1 6.52 0 4 896.95886 -0.2 66.02 3584.81362

TQILVGVNK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 2 1 4557351 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.163 1 0.945 1 1.03 1 1.09 1 1.231 1 1.302 1 1.195 1 3.5 0 2 574.33136 0.22 16.16 1147.65544

TQLVNVAIFGPPWMAFK MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 4 1 71274107 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.103 1 0.995 1 1.016 1 1.021 1 1.184 1 1.189 1 1.165 1 2.91 0 2 497.29538 -1.51 49.55 993.58348

TQNLAALLHAIAR ERAP2 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]

64167 NP_001123612 2 1 194306629 N-Term(iTRAQ4plex) 1.868 1 1.111 1 1.887 1 1.698 1 2.057 1 1.851 1 1.09 1 3.02 1 2 867.01343 -19.48 22.1 1733.01958

TQPNLDNCPFHDQPHLK CST3 cystatin-C precursor [Homo sapiens]

1471 NP_000090 8 1 4503107 N-Term(iTRAQ4plex); C8(Methylthio); K17(iTRAQ4plex)

2.495 2 0.7 0.903 2 8.8 2.363 2 2 2.618 2 10.8 2.38 2 11.7 2.636 2 2.9 1.007 2 13.8 87 6.39 0 2 1087.5914 2.75 39.88 2174.17558

TQSGLQSYLLQFHGLVR PROCR endothelial protein C receptor precursor [Homo sapiens]

10544 NP_006395 4 1 34335272 N-Term(iTRAQ4plex) 2.449 2 6.4 0.924 2 4.7 2.187 2 6.4 2.368 2 11.2 2.525 2 2.2 2.733 2 6.9 1.154 2 4.2 72 4.93 0 2 874.92566 0.69 54.05 1748.84062

TQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFK

ROBO4 roundabout homolog 4 precursor [Homo sapiens]

54538 NP_061928 2 1 17511435 N-Term(iTRAQ4plex); K37(iTRAQ4plex)

1.941 2 30.9 0.857 2 31.8 1.713 2 47.9 1.999 2 14.5 1.911 2 45.8 2.23 2 12.7 1.115 2 1.8 67 5.11 0 2 844.36652 -2.72 33.86 1687.72576

TQVADAK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 27 1 70778918 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.23 1 0.956 1 2.003 1 2.095 1 2.358 1 2.467 1 1.177 1 45 4.25 0 2 742.85303 -0.46 40.6 1484.69878

TQVSTQAEQLR APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 22 1 71773110 N-Term(iTRAQ4plex) 1.6 2 28.9 0.948 2 7 1.409 2 27.1 1.486 2 34.7 1.708 2 23.8 1.801 2 31.3 1.212 2 3.2 6.35 0 4 710.5849 -0.8 53.69 2839.31777

TSALSAK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 36 5 32483410 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.554 1 1.116 1 1.724 1 1.545 1 1.564 1 1.401 1 0.907 1 5.11 0 4 710.5849 -0.8 53.69 2855.31728

TSCLLFMGR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 12 1 73858566 N-Term(iTRAQ4plex); C3(Methylthio)

0.638 6 25.6 1.298 6 45.9 0.729 6 68.8 0.618 6 33.2 0.67 6 9.9 0.577 6 16.4 0.902 6 38.8 165 7.75 0 3 968.4184 -0.18 20.57 1935.83091

TSCLLFMGR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 1 1 73858566 N-Term(iTRAQ4plex); C3(Methylthio); M7(Oxidation)

0.737 5 26.4 1.201 5 2.6 0.781 5 19.9 0.65 5 37.6 0.866 4 9.6 0.719 4 18.9 1.156 4 1 115 5.65 0 2 937.98822 -0.37 24.53 1874.97246

TSESGELHGLTTEEEFVEGIYK

TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 16 1 4507725 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

0.573 1 0.938 1 0.485 1 0.517 1 0.625 1 0.667 1 1.289 1 97 5.13 0 2 688.85339 -0.32 22.4 1376.69951

TSESGLPSTR F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 4 1 4503627 N-Term(iTRAQ4plex) 0.573 3 2.8 0.997 3 7.1 0.554 3 0.6 0.53 3 4 0.608 3 11.6 0.61 3 4.4 1.183 3 11 84 4.57 0 2 690.31915 0.15 22.63 1379.63103

TSESGTPSSSTPQENTISGYSLLTCK

KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 6 1 78191798 N-Term(iTRAQ4plex); C25(Methylthio); K26(iTRAQ4plex)

0.747 1 0.949 1 0.695 1 0.732 1 0.761 1 0.801 1 1.093 1 81 6.61 0 2 1063.593 4.3 39.12 2126.17876

TSGMQFCVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 11 2 38016947 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

0.949 2 14.8 1.14 2 25 0.998 2 18.5 0.876 2 6.3 1.036 2 38.3 0.908 2 12.4 1.037 2 18.8 77 5.56 0 3 825.74744 1.6 75.04 2475.22776

TSIVHLFEWR AMY2A pancreatic alpha-amylase precursor [Homo sapiens]

279 NP_000690 XP_003960156

2 3 4502085 N-Term(iTRAQ4plex) 0.771 3 16.9 1.194 3 12.6 0.784 3 29.5 0.656 3 13.1 0.908 3 23.1 0.76 3 6.9 1.159 3 6.1 69 4.82 0 2 739.90875 -1.7 22.14 1478.80351

TSIYPFLDFMPSPQVVR BTD biotinidase precursor [Homo sapiens]

686 NP_000051 2 1 4557373 N-Term(iTRAQ4plex); M10(Oxidation)

0.759 1 0.76 1 0.817 1 1.075 1 0.518 1 0.682 1 0.634 1 64 6.22 0 3 825.74744 1.6 75.04 2459.23423

TSIYPFLDFMPSPQVVR BTD biotinidase precursor [Homo sapiens]

686 NP_000051 10 1 4557373 N-Term(iTRAQ4plex) 0.717 2 26.8 1.02 2 15.4 0.673 2 34.3 0.66 2 18.2 0.777 2 35.8 0.762 2 19.5 1.154 2 1.3 56 4.29 0 2 705.40002 3.47 20.1 1409.79277

TSLEDFYLDEER SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 9 1 39725934 N-Term(iTRAQ4plex) 1.15 1 0.836 1 1.029 1 1.231 1 1.082 1 1.294 1 1.051 1 55 3.86 0 3 950.4256 -0.38 48.43 2849.26224

TSNFNAAISLK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 39 1 4502511 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.613 1 0.949 1 0.557 1 0.587 1 0.639 1 0.673 1 1.147 1 49 0 2 739.90875 -1.7 22.14 1494.79936

TSPVDEK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 24 1 4557287 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.569 5 7.1 0.765 5 15.6 0.444 5 28.4 0.58 5 14.1 0.513 5 25.3 0.67 5 49.6 1.155 5 25.6 47 9.04 1 4 1667.8612 -0.49 62.05 3334.7228

TSQCTLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 5 1 105990532 N-Term(iTRAQ4plex); C4(Methylthio); K7(iTRAQ4plex)

0.607 2 12.1 0.947 2 21.3 0.551 2 19.3 0.582 2 1.9 0.634 2 25.4 0.669 2 3.9 1.15 2 5.8 46 3.16 0 2 486.80685 -1.68 11.74 972.60344

TSRAVQEAGLGLSTGLRLAESR

CROCC rootletin [Homo sapiens] 9696 NP_055490 XP_371227

1 1 153791497 N-Term(iTRAQ4plex) 0.692 2 1.2 1.044 2 10.2 0.651 2 4 0.624 2 6.1 0.764 2 8.4 0.732 2 1.7 1.173 2 4.4 44 4.24 0 2 605.30316 -1.98 14 1209.60295

TSSFALNLPTLPEVK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 27 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

0.771 1 1.084 1 0.738 1 0.681 1 0.87 1 0.802 1 1.178 1 43 3.26 0 2 602.83521 -1.9 34.04 1204.66313

TSSSFEVR SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 2 4 7382460 N-Term(iTRAQ4plex) 0.768 1 0.939 1 0.661 1 0.704 1 0.827 1 0.881 1 1.251 1 43 3.31 0 2 609.81396 -2.36 32.48 1218.62065

TSTADYAMFK FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.063 1 0.999 1 1.065 1 1.066 1 1.059 1 1.061 1 0.995 1 40 6.51 0 4 888.93262 -2.66 48.67 3552.70864

TSTDLDVDVDQPK LTBP1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor [Homo sapiens]

4052 NP_001159738 1 5 261337173 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

0.605 1 0.907 1 0.509 1 0.561 1 0.646 1 0.712 1 1.269 1 35 0 2 529.26428 10.19 28.25 1057.52129

TSTSEEVCSFYLK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 33 2 38016947 N-Term(iTRAQ4plex); C8(Methylthio); K13(iTRAQ4plex)

0.705 1 1.015 1 0.713 1 0.702 1 0.709 1 0.698 1 0.994 1 35 0 2 605.30316 -1.98 14 1225.59599

TTCNPCPLGYK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 3 1 89191868 N-Term(iTRAQ4plex); C3(Methylthio); C6(Methylthio); K11(iTRAQ4plex)

0.642 1 1.005 1 0.614 1 0.611 1 0.672 1 0.669 1 1.094 1 34 2.97 0 2 529.26428 10.19 28.25 1041.51604

TTCWDGK CFHR1;CFH complement factor H-related protein 1 precursor [Homo sapiens];complement factor H isoform a precursor [Homo sapiens]

3078;3075 NP_002104;NP_000177

2 2 118442839;62739186

N-Term(iTRAQ4plex); C3(Methylthio); K7(iTRAQ4plex)

0.641 2 15.5 0.93 2 9.2 0.604 2 18.6 0.649 2 9.2 0.635 2 21.4 0.682 2 12 1.052 2 2.8 33 3.08 0 2 605.80878 7.89 34.82 1210.61028

TTDVTQTFGIEK HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 2 1 4504383 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

15 0 5 1024.2151 1.49 11.96 5117.04633

TTGGKDEEVVQCLSDGWSSQPTCR

F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 24 1 110611237 N-Term(iTRAQ4plex); K5(iTRAQ4plex); C12(Methylthio); C23(Methylthio)

1.414 1 1.409 1 1.686 1 1.196 1 1.721 1 1.221 1 1.021 1 6.56 1 4 703.12805 -1.45 46.88 2809.49038

TTGIVMDSGDGVTHTVPIYEGYALPHAILR

ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 2 2 4501885 N-Term(iTRAQ4plex) 1.176 1 0.603 1 0.859 1 1.425 1 1.025 1 1.702 1 1.194 1 4.75 0 4 878.62695 0.03 15.4 3511.48598

TTIEK ADAM12 disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein [Homo sapiens]

8038 NP_003465 1 1 73747885 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.381 1 1.039 1 1.147 1 1.104 1 1.669 1 1.607 1 1.455 1 4.59 0 3 791.41223 5.94 64.58 2372.22214

TTIEKPVWLGFLGPIIK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 193 1 4557485 N-Term(iTRAQ4plex); K5(iTRAQ4plex); K17(iTRAQ4plex)

0.739 1 1.052 1 0.752 1 0.715 1 0.765 1 0.727 1 1.017 1 3.46 1 2 798.44147 -3.87 20.93 1595.87566

TTLQQEKPDFCFLEEDPGICR

TFPI tissue factor pathway inhibitor isoform b precursor [Homo sapiens]

7035 NP_001027452 2 2 73760409 N-Term(iTRAQ4plex); K7(iTRAQ4plex); C11(Methylthio); C20(Methylthio)

1.351 1 0.966 1 1.317 1 1.363 1 1.339 1 1.386 1 1.017 1 3.51 2 3 696.07538 12.28 57.43 2086.21158

TTLSGAPCQPWASEATYR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 17 1 145275213 N-Term(iTRAQ4plex); C8(Methylthio)

0.962 1 0.976 1 0.782 1 0.802 1 1.119 1 1.147 1 1.43 1 57 7.03 0 3 743.34271 2.43 17.07 2228.01358

TTLTAFGFASADLIEIGLEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 86 1 105990532 N-Term(iTRAQ4plex); K21(iTRAQ4plex)

1.322 1 0.808 1 1.2 1 1.485 1 1.191 1 1.474 1 0.993 1 3.95 0 3 819.42761 -3.47 40.77 2456.26828

TTMDPNDVILATHASVDNLLHLSGLLER

B3GNT1 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Homo sapiens]

11041 NP_006867 3 1 5802984 N-Term(iTRAQ4plex) 1.449 2 3.4 1.012 2 4 1.325 2 5.5 1.309 2 1.5 1.592 2 5.4 1.573 2 1.4 1.202 2 0.1 3.77 1 3 735.43909 4.23 45.32 2204.30271

TTNIQGINLLFSSR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

157 6 178557739;67190748

N-Term(iTRAQ4plex) 1.461 3 0.6 1.021 3 1.2 1.369 3 1.2 1.34 3 0 1.584 3 2.2 1.528 3 3.4 1.14 3 0.7 32 0 2 488.32617 0.98 22.22 975.64507

TTNIQGINLLFSSRRGHLFLQTDQPIYNPGQR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

1 6 178557739;67190748

N-Term(iTRAQ4plex) 2.043 1 0.966 1 1.859 1 1.925 1 2.157 1 2.233 1 1.16 1 33 0 2 651.31378 0 21.14 1301.62029

TTNLNTCGDSAETASTR VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 7 1 223633991 N-Term(iTRAQ4plex); C7(Methylthio)

1.107 2 10.6 1.005 2 27 1.057 2 26.4 1.052 2 0.6 1.17 2 22.2 1.165 2 4.7 1.107 2 4.1 53 3.79 0 2 645.29883 -15.87 20.96 1289.60954

TTPPTTATPIR FN1 fibronectin isoform 6 preproprotein [Homo sapiens]

2335 NP_997639 2 4 16933542 N-Term(iTRAQ4plex) 1.344 2 7.8 0.861 2 8.6 1.309 2 25.1 1.521 2 34.3 1.166 2 19.9 1.355 2 11.1 0.891 2 46.7 41 9.54 0 4 798.1731 0.31 74.69 3189.67055

TTPSYVAFTDTER HSPA8 heat shock cognate 71 kDa protein isoform 2 [Homo sapiens]

3312 NP_694881 2 6 24234686 N-Term(iTRAQ4plex) 1.313 1 0.767 1 1.017 1 1.325 1 1.304 1 1.699 1 1.282 1 70 9.06 0 3 1006.8327 2.57 44.08 3018.48355

TTSGIHPK PPBP platelet basic protein preproprotein [Homo sapiens]

5473 NP_002695 5 1 4505981 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.078 1 1.05 1 1.063 1 1.012 1 1.147 1 1.092 1 1.079 1 27 0 2 697.32471 -3.13 29.6 1393.64214

TTVILPLAPFVR CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 N-Term(iTRAQ4plex) 1.466 1 0.945 1 1.349 1 1.428 1 1.502 1 1.589 1 1.113 1 2.9 0 2 590.79767 -4.63 38.28 1180.58806

TTVLYECCPGYMR POSTN periostin isoform 4 precursor [Homo sapiens]

10631 NP_001129408 1 4 209863034 N-Term(iTRAQ4plex); C7(Methylthio); C8(Methylthio)

0.96 2 13.4 0.976 2 30.5 0.849 2 28.1 0.87 2 2.3 1.057 2 29 1.084 2 1.4 1.245 2 0.9 98 4.35 0 2 1182.0494 -1.62 51 2363.0916

TTVSNVK GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 2 1 6006001 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.248 13 19.5 0.994 13 15.1 1.132 13 21 1.239 13 20 1.321 13 23.3 1.438 13 25.4 1.154 13 3.9 93 6.62 0 3 1181.14 -0.25 71.61 2361.27353

TVAACNLPIVR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 54 1 4502067 N-Term(iTRAQ4plex); C5(Methylthio)

1.179 10 9.5 0.96 10 22.7 1.072 10 26.5 1.095 10 8.3 1.234 10 20.2 1.232 10 8.5 1.126 10 4.1 81 4.85 0 2 827.91101 -3.89 45.05 1654.80986

TVAANVIGIGEPSRPSEK CNTN4 contactin-4 isoform d [Homo sapiens]

152330 NP_001193885 2 3 332688247 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.341 4 25.9 0.959 4 6.2 1.284 4 23.4 1.243 4 15 1.441 4 31.3 1.395 4 24.1 1.114 4 7.8 76 3.99 0 2 976.49255 2.03 41.13 1951.97588

TVAILLK PTPRG receptor-type tyrosine-protein phosphatase gamma [Homo sapiens]

5793 NP_002832 2 1 194097398 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.253 3 11.3 1.055 3 0.8 1.264 3 6.6 1.12 3 3.1 1.403 3 4.9 1.244 3 15.7 1.097 3 1.7 66 4.47 0 2 819.43066 -5.17 26.83 1637.85405

TVCLPDGSFPSGSECHISGWGVTETGK

HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 12 2 295054188 N-Term(iTRAQ4plex); C3(Methylthio); C15(Methylthio); K27(iTRAQ4plex)

0.827 3 7.7 0.746 3 146 0.645 3 36.6 0.865 3 81.6 0.799 3 55.8 1.072 3 19.8 1.239 3 16.7 64 6.63 0 3 1230.2327 -2.23 52.76 3688.68344

TVDNFVALATGEK PPIB peptidyl-prolyl cis-trans isomerase B precursor [Homo sapiens]

5479 NP_000933 2 1 4758950 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.341 1 1.11 1 1.35 1 1.217 1 1.48 1 1.333 1 1.096 1 58 2.89 0 2 666.3551 -1.22 17.25 1331.70293

TVESITDIR LAMP1 lysosome-associated membrane glycoprotein 1 precursor [Homo sapiens]

3916 NP_005552 2 1 112380628 N-Term(iTRAQ4plex) 1.297 12 9.3 1.092 12 12.5 1.293 12 11.8 1.197 12 7.3 1.403 12 18.3 1.341 12 9.4 1.121 12 7.7 56 3.08 0 2 600.89886 -4.52 39.5 1200.78996

TVFGTEPDMIR CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 4 1 21071039 N-Term(iTRAQ4plex) 1.042 5 3.7 0.869 5 7.3 0.95 5 4.3 1.084 5 3.7 1.047 5 9.2 1.123 5 8.6 1.07 5 4.5 34 3.56 0 2 678.84308 -4.59 21.55 1356.68645

TVGSDTFYSFK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

217 3 4504893;156231037

N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.154 4 5.3 0.959 4 9.4 1.108 4 4 1.133 4 6.9 1.223 4 3.5 1.306 4 7.5 1.107 4 0.9 30 3.03 0 2 569.7843 0.34 10.38 1138.56072

Page 40: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

TVIEVDER SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 4 1 7705879 N-Term(iTRAQ4plex) 0.889 1 0.812 1 0.722 1 0.89 1 0.889 1 1.095 1 1.23 1 29 2.83 0 2 578.74347 -1.91 21.98 1156.47966

TVIGPDGHK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 4 2 4503689 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.704 1 5.452 1 7.027 1 1.289 1 10.42 1 1.911 1 1.483 1 27 5 0 4 1230.2327 -2.23 52.76 3704.69961

TVIRFVTNK ELK3 ETS domain-containing protein Elk-3 [Homo sapiens]

2004 NP_005221 1 1 44955921 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

4.276 1 1.126 1 4.391 1 3.898 1 4.702 1 4.175 1 1.071 1 36 0 2 519.81018 5.48 17.9 1038.61308

TVLQQNPIPMMDR PDE6A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [Homo sapiens]

5145 NP_000431 1 1 170650674 N-Term(iTRAQ4plex); M10(Oxidation)

0.651 1 1.024 1 0.574 1 0.561 1 0.744 1 0.727 1 1.296 1 52 4.2 0 3 504.57715 -3.72 17.33 1511.71689

TVMVNIENPEGIPVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 10 1 115298678 N-Term(iTRAQ4plex); M3(Oxidation); K15(iTRAQ4plex)

1.064 1 0.722 1 0.844 1 1.169 1 0.988 1 1.368 1 1.17 1 48 3.71 0 2 650.37927 -2.97 41.27 1299.75127

TVMVNIENPEGIPVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 15 1 115298678 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.117 1 0.954 1 1.021 1 1.07 1 1.162 1 1.217 1 1.137 1 77 3.71 0 2 793.83612 -2.94 21.47 1586.66496

TVQAVLTVPK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 10 1 39725934 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.334 2 4.7 0.875 2 13.6 1.157 2 12.8 1.323 2 0.7 1.345 2 9.6 1.538 2 4 1.162 2 3.2 55 5.18 0 2 777.92358 0.13 48.13 1554.83989

TVVQPSVGAAAGPVVPPCPGR

AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 42 1 156523970 N-Term(iTRAQ4plex); C18(Methylthio)

1.285 1 0.899 1 1.118 1 1.243 1 1.322 1 1.47 1 1.182 1 34 3.52 0 2 683.81653 0.43 36.5 1366.62578

TWDPEGVIFYGDTNPK SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 10 4 7382460 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.733 1 0.93 1 0.642 1 0.69 1 0.773 1 0.831 1 1.204 1 70 3.71 0 2 823.90826 -0.63 21.2 1646.80925

TWNDPSVQQDIK HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 4 1 16507237 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.162 6 2.9 0.962 6 5.2 1.043 6 3 1.07 6 4.4 1.234 6 5.6 1.269 6 6.4 1.183 6 6.8 91 4.94 0 2 883.9126 0.51 36.13 1766.81792

TWQDCEYK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

56 3 4504893;156231037

N-Term(iTRAQ4plex); C5(Methylthio); K8(iTRAQ4plex)

1.739 8 14.5 0.943 8 13.7 1.618 8 15.8 1.704 8 11.9 1.743 8 21.8 1.951 8 9 1.108 8 6.6 63 4.9 0 2 922.00684 0.66 23.84 1842.99663

TYCSEPEK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 8 1 4557485 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex)

1.653 9 3 0.975 9 7.8 1.515 9 8.1 1.624 9 3.7 1.683 9 4.6 1.803 9 5.4 1.112 9 3.5 50 4.18 0 2 729.91565 -1.36 38.15 1458.82939

TYCSEPEKVDKDNEDFQESNR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 3 1 4557485 N-Term(iTRAQ4plex); C3(Methylthio); K8(iTRAQ4plex); K11(iTRAQ4plex)

1.53 4 3.9 0.972 4 8.7 1.462 4 4.1 1.551 4 3.3 1.546 4 4.6 1.636 4 4.1 1.061 4 2 40 6.94 0 3 748.41388 2.44 82.08 2243.22013

TYHVGEQWQK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

1 5 47132549;16933542

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.573 3 12.9 0.842 3 10.5 1.229 3 3.5 1.789 3 3.2 1.427 3 0.1 2.117 3 0.7 1.16 3 0.3 38 0 2 553.82813 0.11 32.41 1106.64897

TYIYDHGFPYTDPVGVLYEDGDDTVATR

LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 6 1 4557892 N-Term(iTRAQ4plex) 1.824 6 9.2 1.082 6 16.6 1.773 6 20.1 1.641 6 3.8 2.024 6 16.4 1.872 6 5.1 1.139 6 0.8 38 2.97 0 2 619.84668 1.18 37.01 1238.68291

TYLGNALVCTCYGGSR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

25 6 47132549;16933542

N-Term(iTRAQ4plex); C9(Methylthio); C11(Methylthio)

1.334 1 1.005 1 1.271 1 1.264 1 1.404 1 1.396 1 1.104 1 38 2.79 0 2 518.81476 -1.79 9.72 1036.62224

TYLPAVDEK APOC2 apolipoprotein C-II precursor [Homo sapiens]

344 NP_000474 5 1 32130518 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.469 4 4.7 0.982 4 4.7 1.394 4 9.9 1.42 4 7.4 1.518 4 2.6 1.596 4 5.1 1.105 4 2.5 37 3.25 0 2 586.79736 -4.28 37.13 1172.58891

TYMLAFDVNDEK ORM1 alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5004 NP_000598 2 1 167857790 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.72 3 8.9 0.913 3 8.3 1.414 3 11.4 1.647 3 13.7 1.782 3 5.2 1.913 3 12.1 1.178 3 10 34 0 2 729.91565 -1.36 38.15 1474.81975

TYNVLDMK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

184 6 178557739;67190748

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.827 1 1.285 1 2 1 1.557 1 2.175 1 1.694 1 1.088 1 31 0 2 506.27872 -0.05 23.55 1011.55016

TYNVLDMK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

4 6 178557739;67190748

N-Term(iTRAQ4plex); M7(Oxidation); K8(iTRAQ4plex)

1.954 2 11.1 0.965 2 6.7 1.783 2 8.8 1.848 2 15.5 2.057 2 6.9 2.132 2 13.6 1.154 2 1.9 30 0 2 586.79736 -4.28 37.13 1188.58757

TYSDHPEK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 3 1 4557485 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.377 1 1.071 1 1.331 1 1.243 1 1.522 1 1.421 1 1.143 1 3.76 0 4 803.62146 12.27 44.42 3211.46401

TYSVEYLDSSK LCAT phosphatidylcholine-sterol acyltransferase precursor [Homo sapiens]

3931 NP_000220 5 1 4557892 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.279 1 1.004 1 1.213 1 1.208 1 1.349 1 1.344 1 1.112 1 47 4.04 0 2 758.47614 4.63 70.68 1515.94499

TYVPPPFSQDLFTFHADMCQSQNEELQR

AFM afamin precursor [Homo sapiens] 173 NP_001124 52 1 4501987 N-Term(iTRAQ4plex); C19(Methylthio)

1.404 1 0.869 1 1.165 1 1.341 1 1.459 1 1.679 1 1.252 1 39 0 3 440.931 2.11 21.69 1320.77845

TYVPPPFSQDLFTFHADMCQSQNEELQR

AFM afamin precursor [Homo sapiens] 173 NP_001124 16 1 4501987 N-Term(iTRAQ4plex); M18(Oxidation); C19(Methylthio)

1.311 1 1 1 1.28 1 1.28 1 1.342 1 1.342 1 1.048 1 30 1 4 427.2662 -8.07 21.62 1706.04299

TYYIAAVEVEWDYSPQR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 96 1 4557485 N-Term(iTRAQ4plex) 1.231 3 1.4 1.072 3 4.7 1.25 3 3.8 1.167 3 0.8 1.3 3 3.8 1.213 3 0.9 1.039 3 0 4.45 1 4 731.38562 -1.97 63.7 2922.52065

VAAGAFQGLR LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 14 1 16418467 N-Term(iTRAQ4plex) 0.748 2 18.3 0.999 2 19.1 0.705 2 28.5 0.706 2 9.1 0.792 2 27.8 0.793 2 8.4 1.123 2 0.7 77 3.8 0 2 756.91602 -3.51 18.75 1512.81743

VAATGSRGELMLEANSINR KIF12 kinesin-like protein KIF12 [Homo sapiens]

113220 NP_612433 1 1 19923949 N-Term(iTRAQ4plex); M11(Oxidation)

0.985 6 9.4 0.955 6 12.5 0.887 6 9.2 0.943 6 5.6 1.017 6 12.6 1.035 6 5.8 1.113 6 5.7 77 5.9 0 2 972.9856 -0.51 49.78 1944.97087

VACEEPPFIENGAANLHSK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 4 1 110611237 N-Term(iTRAQ4plex); C3(Methylthio); K19(iTRAQ4plex)

1.027 2 3.4 0.887 2 11.9 0.995 2 5.3 1.122 2 17.3 0.941 2 10.1 1.062 2 1.8 0.946 2 15.4 59 5.76 0 3 544.60815 -0.42 10.56 1631.81247

VADFLSWCR BST1 ADP-ribosyl cyclase 2 precursor [Homo sapiens]

683 NP_004325 6 1 168229159 N-Term(iTRAQ4plex); C8(Methylthio)

0.859 2 14.2 0.964 2 15 0.819 2 19.6 0.849 2 4.5 0.869 2 23.7 0.901 2 8.4 1.061 2 3.9 42 3.26 0 2 545.32874 -3.25 26.15 1089.65569

VAEYMDWILEK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 42 1 78191798 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

0.913 5 7.8 0.903 5 6.8 0.773 5 2.5 0.907 5 15.5 0.918 5 4.2 1.058 5 8.9 1.18 5 6.9 38 3.71 0 3 1078.5402 0.96 41.64 2156.07437

VAFLTVTLHQGGATR GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 13 1 29171717 N-Term(iTRAQ4plex) 0.887 2 3.6 1.064 2 7.6 0.894 2 1.7 0.84 2 9.3 0.938 2 2.2 0.882 2 5.4 1.05 2 4 31 0 2 444.33206 4.09 18.18 887.65685

VAFPLEVVQK IL1RAP interleukin-1 receptor accessory protein isoform 2 precursor [Homo sapiens]

3556 NP_608273 2 3 19882209 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.906 1 0.848 1 0.768 1 0.905 1 0.907 1 1.069 1 1.181 1 30 0 2 515.19495 8.09 29.59 1029.38262

VAGLLEDTFPGLLGLR IGFALS insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor [Homo sapiens]

3483 NP_004961 17 2 4826772 N-Term(iTRAQ4plex) 0.731 1 1.03 1 0.684 1 0.664 1 0.8 1 0.777 1 1.17 1 26 3.68 0 2 669.29095 -0.53 46.28 1337.57463

VAIIIPFR B4GALT1 beta-1,4-galactosyltransferase 1 [Homo sapiens]

2683 NP_001488 2 1 13929462 N-Term(iTRAQ4plex) 0.836 1 1.02 1 0.787 1 0.772 1 0.901 1 0.883 1 1.145 1 24 2.77 0 2 572.74628 -2.71 17.61 1144.48528

VALICLPPEWYVVPPGTK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 8 1 205277383 N-Term(iTRAQ4plex); C5(Methylthio); K18(iTRAQ4plex)

1.142 3 13.1 0.928 3 4.3 1.033 3 22 1.113 3 1.6 1.168 3 9.4 1.258 3 5.1 1.213 3 1.9 54 4.96 1 2 905.40637 2.08 33.66 1809.80364

VANYFDWISYHVGRPFISQYNV

CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 58 1 119392081 N-Term(iTRAQ4plex) 0.871 5 8.3 1.017 5 10.8 0.829 5 8.2 0.828 5 10.8 0.891 5 20 0.891 5 8.4 1.075 5 21.3 51 4.6 0 3 531.92047 -1.4 30.22 1593.7529

VANYVDWINDR HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 4 1 4504383 N-Term(iTRAQ4plex) 1.044 3 2.8 0.948 3 15 1.015 3 12.7 1.087 3 2.2 1.008 3 4.1 1.176 3 19.1 1.081 3 16.9 36 4.91 0 3 663.66284 2.45 40.47 1988.9727

VAPEEHPVLLTEAPLNPK ACTB actin, cytoplasmic 1 [Homo sapiens] 60 NP_001092 10 2 4501885 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

2.029 3 13.2 1.057 3 10.5 1.748 3 34.5 1.619 3 7.4 2.369 3 12.9 2.241 3 2.4 1.227 3 18.9 100 5.02 0 2 897.45135 6.92 34.61 1793.87688

VAQLEAQCQEPCK FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); C8(Methylthio); C12(Methylthio); K13(iTRAQ4plex)

1.146 4 8.2 0.863 4 25.6 1.005 4 22.7 1.187 4 7.1 1.155 4 20 1.378 4 4.5 1.127 4 5.5 97 5.58 0 2 897.45135 6.92 34.61 1777.89128

VAQVIIPSTYVPGTTNHDIALLR

F7 coagulation factor VII isoform b precursor [Homo sapiens]

2155 NP_062562 4 2 10518503 N-Term(iTRAQ4plex) 1.288 12 14.6 0.922 12 33.8 1.264 12 13.7 1.353 12 41.4 1.218 12 15 1.351 12 28.9 1.019 12 22.9 64 7.93 0 3 957.87036 0.89 78.45 2871.59653

VASHLEVNCDKR GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 2 1 291190772 N-Term(iTRAQ4plex); C9(Methylthio); K11(iTRAQ4plex)

1.373 5 16.5 0.972 5 11.2 1.319 5 21 1.329 5 8.2 1.456 5 15.5 1.543 5 11 1.11 5 6.1 48 3.37 0 2 600.80377 -1.24 41.62 1200.59734

VASVDMGPQQLPDGQSLPIPPVILAELGSDPTK

CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 2 1 21071039 N-Term(iTRAQ4plex); K33(iTRAQ4plex)

1.011 6 6.2 0.914 6 6 0.979 6 11.2 1.05 6 2.7 1.013 6 16.6 1.115 6 1.1 1.071 6 6.6 44 3.84 0 2 657.83362 -3.44 35.62 1314.65947

VASYGVKPR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 8 1 67782358 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.219 3 13.6 0.965 3 8.9 1.155 3 21.9 1.197 3 11 1.241 3 16.1 1.286 3 3.6 1.1 3 3.4 42 2.97 0 2 621.84375 -0.69 20.57 1242.67937

VATTVISK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 4 1 73858568 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.235 192 13.3 0.972 192 19.7 1.173 192 23.8 1.199 192 14.8 1.323 192 20.4 1.366 192 12.4 1.121 192 7.8 149 7.03 0 3 1047.0116 1.21 68.44 2093.01592

VATYLPAPEGLK TNC tenascin precursor [Homo sapiens] 3371 NP_002151 2 1 153946395 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.24 113 10.4 0.961 113 12.9 1.148 113 14.7 1.183 113 15 1.272 113 13.7 1.307 113 13.1 1.123 113 12.8 116 7.42 0 3 1148.5472 0.57 54.75 2296.08721

VAVVEYHDGSHAYIGLK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.361 209 20.9 0.969 209 16 1.269 209 22.5 1.324 209 27.1 1.474 209 23.3 1.513 209 23.4 1.157 209 12.7 107 6.89 0 3 1339.6428 -0.19 62.42 2678.27837

VAWHYDEEKIEFEWNTGTNVDTK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K23(iTRAQ4plex)

1.152 8 9.4 0.989 8 8 1.113 8 8.9 1.122 8 12.8 1.192 8 5.6 1.167 8 13 1.072 8 8 95 6.04 0 3 1077.523 -2.52 40.19 2154.05619

VAYDLVYYVR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

4 1 154146262 N-Term(iTRAQ4plex) 1.177 49 8.9 0.88 49 22.5 1.051 49 17.6 1.22 49 13.4 1.136 49 17 1.372 49 13.2 1.111 49 6.9 93 5.7 0 2 879.94373 0.21 55.82 1758.87956

VCEGAACK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); C2(Methylthio); C7(Methylthio); K8(iTRAQ4plex)

1.189 39 5.5 0.976 39 11.5 1.11 39 7.9 1.153 39 10.8 1.259 39 10.4 1.291 39 9.8 1.139 39 8 91 6.98 0 4 1222.5538 1.89 33.34 2444.09682

VCELDENNTPMCVCQDPTSCPAPIGEFEK

SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 2 1 4507171 N-Term(iTRAQ4plex); C2(Methylthio); C12(Methylthio); C14(Methylthio); C20(Methylthio); K29(iTRAQ4plex)

1.295 57 19.4 0.925 56 35.5 1.102 57 27.6 1.263 56 36.9 1.331 57 31.8 1.398 56 32.5 1.159 57 26.8 89 9.37 0 5 1063.5249 2.02 44.13 3188.5563

VCPFAGILENGAVR APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 24 1 153266841 N-Term(iTRAQ4plex); C2(Methylthio)

1.263 11 9.9 1 11 16.7 1.221 11 17.4 1.211 11 8.3 1.369 11 13.4 1.399 11 14.1 1.192 11 4.1 89 6.67 0 2 1082.468 2.55 27.66 2163.91973

VCQPPPDVLHAER CR1L complement component receptor 1-like protein precursor [Homo sapiens]

1379 NP_783641 XP_114735 XP_942024

2 3 148922949 N-Term(iTRAQ4plex); C2(Methylthio)

1.252 49 14.7 0.979 49 16.7 1.236 49 22.7 1.243 49 24.1 1.28 49 18.5 1.341 49 17.3 1.107 49 19.9 89 7.62 0 4 1445.7129 -5.69 39.76 2890.44106

VCSQYAAYGEK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 112 2 32483410 N-Term(iTRAQ4plex); C2(Methylthio); K11(iTRAQ4plex)

1.458 3 12.7 1.006 3 17.7 1.299 3 12.4 1.506 3 7.3 1.356 3 1.3 1.483 3 15.7 1.044 3 8.7 88 4.86 0 2 1000.9502 -1.6 36.97 2000.89751

VCTAELSCK PRG4 proteoglycan 4 isoform C precursor [Homo sapiens]

10216 NP_001121181 12 2 189181722 N-Term(iTRAQ4plex); C2(Methylthio); C8(Methylthio); K9(iTRAQ4plex)

1.01 60 17.5 0.983 60 21.6 0.939 60 19 0.959 60 28 1.02 60 24.4 1.062 60 22.1 1.089 60 23.7 88 9.75 0 4 1275.6277 4.04 60.89 3824.8685

VDADADPR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 1 1 4557417 N-Term(iTRAQ4plex) 1.398 5 11.5 1.076 5 9.4 1.155 5 21.3 1.143 5 19.1 1.798 5 8.5 1.595 5 15.5 1.209 5 8.7 85 6.15 0 3 1122.0728 -0.93 48.26 2243.13773

VDAETGDVFAIER CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 2 1 166362713 N-Term(iTRAQ4plex) 1.386 2 6.5 1.172 2 9.1 1.428 2 3.6 1.218 2 5.5 1.584 2 6.3 1.351 2 15.5 1.109 2 9.9 83 4.69 0 2 815.45056 -6.88 17.25 1629.89385

VDAFCGGSIVNEK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 16 1 4503649 N-Term(iTRAQ4plex); C5(Methylthio); K13(iTRAQ4plex)

1.262 71 10.4 0.952 71 10.2 1.168 71 13.6 1.215 71 15.9 1.311 71 14.7 1.377 71 13.7 1.155 71 11.6 83 5.98 0 3 842.5036 6.85 28.91 1683.98819

VDALMDEINFMK KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 8 1 119395754 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.311 40 14.6 0.996 40 15.4 1.185 40 10.9 1.197 40 16.1 1.372 40 16.4 1.37 40 18.8 1.119 40 10.1 82 5.9 1 3 524.31317 -3.73 25.17 1570.92203

VDDGVASFVLNLPSGVTVLEFNVK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 30 2 38016947 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.315 22 18.7 1.042 21 21.2 1.179 22 14.7 1.176 21 22.5 1.318 21 18 1.441 21 26.3 1.15 21 12.6 80 6.37 1 2 1269.09 1.85 22.47 2537.17266

VDFTLSSER C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

86 6 178557739;67190748

N-Term(iTRAQ4plex) 1.852 5 18.6 0.816 5 14.6 1.469 5 21.8 2.091 5 6.2 1.878 5 16.3 2.302 5 15.8 1.146 5 11.1 80 5.13 0 3 1151.5538 -0.2 44.66 2302.10062

VDGALCMEK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 534 1 11321561 N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

1.354 4 14.5 0.945 4 19.3 1.238 4 15.1 1.328 4 11.1 1.406 4 15.2 1.429 4 15.8 1.077 4 2.1 79 5.7 0 2 1034.9672 -4.89 29.31 2068.92705

VDGALCMEK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 17 1 11321561 N-Term(iTRAQ4plex); C6(Methylthio); M7(Oxidation); K9(iTRAQ4plex)

1.362 46 12.7 0.977 46 16.1 1.288 46 19.9 1.311 46 14.3 1.403 46 19.8 1.452 46 18.5 1.065 46 11.8 78 5.97 0 3 1209.0376 -2.37 59.91 2417.06792

VDGSVDFYR FCN2 ficolin-2 isoform b precursor [Homo sapiens]

2220 NP_056652 2 2 8051586 N-Term(iTRAQ4plex) 1.109 110 16.4 0.946 110 21.3 0.994 110 25.8 1.069 110 15.3 1.184 110 17.2 1.227 110 18.4 1.145 110 15 78 8.76 0 3 1296.6608 3.58 52.41 2592.31426

VDKDNEDFQESNR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 14 1 4557485 N-Term(iTRAQ4plex); K3(iTRAQ4plex)

1.197 38 10 0.958 38 11.5 1.155 38 10.7 1.123 38 9.2 1.303 38 11.1 1.277 38 11.2 1.129 38 5.1 77 5.27 0 3 906.41077 -2.71 40.59 1811.81792

VDLITFDTPFAGR BTD biotinidase precursor [Homo sapiens]

686 NP_000051 6 1 4557373 N-Term(iTRAQ4plex) 1.188 44 10.8 0.935 44 10.9 1.087 44 16.3 1.141 44 9.6 1.205 44 16.3 1.288 44 10 1.104 44 5.6 76 4.52 0 3 768.90808 -4.44 41.2 1536.81523

VDLLNQEIEFLK KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 16 2 47132620 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.182 20 10 1.002 20 13.3 1.093 20 19.2 1.127 20 7.8 1.222 20 15.9 1.251 20 6.3 1.131 20 5 76 5.73 0 2 966.45978 0.06 29 1931.90557

VDLSFSPAQSPPASHAHLQVAAAPQSLCALR

PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 1 1 162809334 N-Term(iTRAQ4plex); C28(Methylthio)

1.308 23 9.1 0.813 23 7.3 1.145 23 7.2 1.342 23 7.5 1.277 23 10.2 1.522 23 14.5 1.124 23 6 75 6.6 0 3 1159.9904 5.48 35.72 2318.96061

VDLSFSPSQSLPASHAHLR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex) 1.384 7 0.7 0.821 7 13.1 1.137 7 18.8 1.463 7 8.2 1.361 7 6.5 1.632 7 26.9 1.178 7 16.5 74 5.98 0 3 851.77039 0.11 64.25 2553.30082

VDLVDFEDNYQFAK FCN2 ficolin-2 isoform b precursor [Homo sapiens]

2220 NP_056652 4 2 8051586 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.246 30 7.3 1.056 30 12.6 1.205 30 15.4 1.164 30 5.9 1.338 30 12.8 1.309 30 7.1 1.134 30 5 72 4.9 0 2 716.85358 -3.92 25.56 1432.70378

VDRDVAPGTLCDVAGWGIVNHAGR

CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 10 1 42544239 N-Term(iTRAQ4plex); C11(Methylthio)

1.404 2 18.3 0.93 2 29.1 1.307 2 30.1 1.405 2 1 1.414 2 35.2 1.521 2 5.7 1.082 2 4.7 71 3.6 0 2 731.88263 -3.89 19.71 1462.75139

VDTDGNGYISFNELNDLFK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 2 1 167614506 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.13 15 9.5 1.039 15 9.6 1.029 15 18.1 1.074 15 6 1.184 15 14.9 1.203 15 6.9 1.119 15 9.4 69 6.75 1 4 1168.5794 -2.59 22.19 2336.15141

VDTVDPPYPR VTN vitronectin precursor [Homo sapiens]

7448 NP_000629 4 1 88853069 N-Term(iTRAQ4plex) 1.166 42 7.2 0.89 42 12.9 1.028 42 14.3 1.17 42 8.9 1.204 42 10.8 1.338 42 10.4 1.13 42 5.6 69 6.12 0 2 902.9751 5.57 27.14 1804.94292

VDVIPVNLPGEHGQR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

52 5 47132549;16933542

N-Term(iTRAQ4plex) 1.448 1 1.831 1 2.431 1 1.328 1 1.669 1 0.911 1 0.687 1 67 7.46 1 3 1016.1856 1.97 30.89 3046.54209

VDVQAGACEGK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

114 6 178557739;67190748

N-Term(iTRAQ4plex); C8(Methylthio); K11(iTRAQ4plex)

1.842 3 18.1 0.939 3 17.6 1.66 3 28.7 1.768 3 10.7 1.912 3 25.8 2.036 3 8 1.137 3 0.8 67 3.6 0 2 1034.9672 -4.89 29.31 2084.93462

VDVTLPSSYHGAVCGLCGNMDR

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

5 1 154146262 N-Term(iTRAQ4plex); C14(Methylthio); C17(Methylthio)

1.195 22 8.5 1.013 22 12.5 1.185 22 15.5 1.162 22 5.8 1.275 22 15.1 1.275 22 8.4 1.091 22 4.8 65 4.89 0 2 770.37781 -3.57 25.04 1539.74834

VEAMLNDR APP amyloid beta A4 protein isoform f precursor [Homo sapiens]

351 NP_001129602 1 15 209915573 N-Term(iTRAQ4plex) 1.026 6 25.6 1.005 6 21.8 0.886 6 47.6 0.974 6 16.9 1.159 6 20.5 1.044 6 2.1 1.104 6 35.8 63 7.15 0 4 1066.8383 -9.09 27 3198.52871

VEASISK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

10 6 178557739;67190748

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.172 24 11.7 0.936 24 18.8 1.076 24 15.2 1.094 24 12.5 1.207 24 14.1 1.326 24 13.5 1.175 24 9.3 62 5.88 0 3 1151.5538 -0.2 44.66 2286.10674

VECSDNLFTQR MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

2 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C3(Methylthio)

1.201 3 4.9 0.893 3 4 1.068 3 9.9 1.17 3 3.2 1.231 3 6 1.262 3 2.2 1.1 3 2.9 61 6.08 0 3 1082.9702 -5.46 37.22 2164.93814

VEDFGNAWK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.106 9 3.2 0.987 9 7.3 1.884 9 13.6 1.983 9 20 2.119 9 12.7 1.979 9 19.4 1.088 9 8.3 58 5.33 1 4 1168.5794 -2.59 22.19 2352.14077

VEDIPLAR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex) 1.275 4 1.5 0.926 4 6.3 1.158 4 5.3 1.244 4 3.5 1.305 4 1.8 1.409 4 5.9 1.127 4 3.4 57 4.38 0 3 417.55328 4.34 15.69 1250.6453

VEDPESTLFGSVIR C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 18 1 41393602 N-Term(iTRAQ4plex) 1.419 1 1.054 1 1.402 1 1.33 1 1.512 1 1.435 1 1.079 1 57 4.35 0 2 919.9104 -4.24 22.05 1838.81352

VEETCGCR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 1 1 89191868 N-Term(iTRAQ4plex); C5(Methylthio); C7(Methylthio)

0.956 19 13 0.961 19 6.1 0.921 19 10.9 0.919 19 14.4 1.031 19 15.8 0.999 19 10.6 1.13 19 3.6 56 4.99 0 2 641.3349 2.09 36.96 1281.65569

VEFVLK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 1 3 21450863 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.636 3 4.1 0.658 3 50.5 1.68 3 3.5 1.987 3 60 1.332 3 62 1.901 3 9.4 1.019 3 17.9 55 9.28 0 3 1066.8383 -9.09 27 3214.5311

VEGLTFQQNSLNWMK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 8 1 4557287 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.117 14 10.6 0.922 14 8.2 1.052 14 15.6 1.126 14 9.7 1.154 14 19.4 1.26 14 10.3 1.132 14 7.7 54 4.25 0 2 689.83936 -1.02 43.94 1378.66899

VEGLTFQQNSLNWMK AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 2 1 4557287 N-Term(iTRAQ4plex); M14(Oxidation); K15(iTRAQ4plex)

1.02 20 6.5 0.982 20 10.8 0.954 20 11 0.969 20 6.4 1.076 20 12.6 1.108 20 8.1 1.14 20 3.7 53 4.47 0 3 481.19254 -2.53 32.63 1441.56084

VEGTAFVIFGIQDGEQR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 3 1 115298678 N-Term(iTRAQ4plex) 1.096 22 18.7 1.096 22 9.5 1.105 22 18.8 1.019 22 14.9 1.19 22 21.1 1.147 22 19.5 1.115 22 4.8 53 3.46 0 2 626.31122 3.77 25.28 1251.60991

VEKPTADAEAYVFTPNMICAGGEK

C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 4 1 41393602 N-Term(iTRAQ4plex); K3(iTRAQ4plex); M17(Oxidation); C19(Methylthio); K24(iTRAQ4plex)

1.19 50 7.3 0.947 50 8.9 1.089 50 9.2 1.128 50 8.3 1.245 50 8.8 1.268 50 8 1.135 50 3.5 53 3.18 0 2 581.27808 9.47 34.57 1161.53203

VELEDWAGNEAYAEYHFR FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 4 1 4503689 N-Term(iTRAQ4plex) 1.828 12 9.7 0.915 12 8 1.636 12 14.6 1.819 12 8.7 1.802 12 17.1 1.99 12 8.6 1.103 12 5.5 53 3.72 0 3 729.83453 -2.93 30.2 1458.66831

VELEVPQLCSFILK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); C9(Methylthio); K14(iTRAQ4plex)

1.241 19 8.4 0.943 19 7.2 1.109 19 4.7 1.199 19 6.9 1.261 19 7.7 1.349 19 8.6 1.119 19 4.9 52 4.18 0 2 688.30914 0.53 31.33 1375.61101

VELLHNPAFCSLATTK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 32 1 115298678 N-Term(iTRAQ4plex); C10(Methylthio); K16(iTRAQ4plex)

1.098 17 5.4 0.975 17 11.3 1.074 17 14.7 1.04 17 7.9 1.159 17 9.8 1.199 17 12.7 1.096 17 4.8 52 4.11 0 2 729.83453 -2.93 30.2 1442.66973

VELLPK F8 coagulation factor VIII isoform a precursor [Homo sapiens]

2157 NP_000123 2 1 4503647 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.174 8 10.1 0.818 8 13 1.019 8 15.7 1.246 8 11.4 1.108 8 15.6 1.377 8 17.8 1.125 8 7.1 50 3.97 0 3 604.3501 1.1 20.8 1207.68784

VEPLYELVTATDFAYSSTVR C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 80 1 4557391 N-Term(iTRAQ4plex) 1.739 5 13.6 1.052 5 11.3 1.549 5 22.4 1.665 5 4.4 1.761 5 23.7 1.915 5 7 1.174 5 3.1 48 0 2 632.81934 -0.82 27.83 1264.6314

VEPYGENFNK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 13 1 71773110 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.191 42 8.9 1.021 42 8.2 1.123 42 9.7 1.108 42 8.2 1.265 42 11.9 1.222 42 11.6 1.121 42 6.3 48 5.1 0 3 960.4743 -2.63 30.57 1919.94133

VEQAVETEPEPELR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 2 1 4557325 N-Term(iTRAQ4plex) 1.087 4 3.9 0.961 4 6 0.977 4 6.3 1.051 4 5.9 1.122 4 6.2 1.207 4 6.7 1.149 4 0.8 48 3.88 0 2 632.81934 -0.82 27.83 1248.64983

VERFMFEGVEIPLVPSCAVFITMNPGYAGR

DNAH1 dynein heavy chain 1, axonemal [Homo sapiens]

25981 NP_056327 1 1 197927452 N-Term(iTRAQ4plex); C17(Methylthio)

1.411 4 6.2 0.886 4 8 1.284 4 10.9 1.485 4 10.9 1.353 4 8 1.565 4 13.4 1.075 4 4.4 48 4.07 0 2 649.87054 0.01 49.47 1298.73516

VESLEQEAANER APP amyloid beta A4 protein isoform f precursor [Homo sapiens]

351 NP_001129602 4 10 209915573 N-Term(iTRAQ4plex) 1.198 2 11.1 0.969 2 7.1 1.086 2 10.5 1.12 2 3.3 1.272 2 18.3 1.312 2 11.1 1.171 2 7.8 47 4.14 0 2 787.88123 -8.7 24.19 1574.75517

VETEDQVLATFCGR MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

7 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C12(Methylthio)

1.399 1 0.916 1 1.298 1 1.417 1 1.382 1 1.509 1 1.065 1 47 5.15 1 2 952.49207 -5.53 23.01 1903.97685

VETNMAFSPFSIASLLTQVLLGAGENTK

SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 13 1 73858568 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.197 55 8.3 0.945 55 7.9 1.08 55 9.9 1.154 55 6.6 1.236 55 10.5 1.333 55 5.6 1.135 55 2.7 47 4.38 0 2 441.5372 -1.47 46.46 1322.59587

VETNMAFSPFSIASLLTQVLLGAGENTK

SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 4 1 73858568 N-Term(iTRAQ4plex); M5(Oxidation); K28(iTRAQ4plex)

1.025 3 2.4 1.013 3 0.7 0.946 3 2.7 0.98 3 1.4 1.09 3 4.3 1.109 3 2.5 1.141 3 1.1 46 3.6 0 3 694.85309 -4.93 18.12 1388.69995

Page 41: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

VETVDR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

6 6 178557739;67190748

N-Term(iTRAQ4plex) 1.245 7 5.1 0.812 7 7.1 1.059 7 6 1.305 7 3.4 1.163 7 4.3 1.45 7 5.3 1.108 7 3 42 3.94 0 3 425.87793 -0.49 10.62 1275.62601

VEYELSEEGDEPQYLDLPSTATSVNIPDLLPGR

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

12 5 47132549;16933542

N-Term(iTRAQ4plex) 1.223 48 5 0.947 48 6.6 1.102 48 5 1.2 48 5.7 1.25 48 6.3 1.338 48 6.3 1.132 48 3.2 41 3.4 0 2 623.32831 -1.06 32.84 1245.64617

VEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRK

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex); K34(iTRAQ4plex)

1.625 7 21.4 0.963 7 15.8 1.379 7 29.2 1.63 7 24.9 1.621 7 15.1 1.78 7 21.5 1.135 7 5.4 40 2.79 0 2 481.19254 -2.53 32.63 1457.57231

VEYGFQVK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

106 6 178557739;67190748

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.037 2 4.8 0.959 2 4.5 0.974 2 9.9 1.016 2 5.4 1.058 2 4.3 1.103 2 0.3 1.086 2 5.7 39 2.96 0 2 641.3349 2.09 36.96 1297.65508

VFAILENK TNC tenascin precursor [Homo sapiens] 3371 NP_002151 2 1 153946395 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.49 1 0.867 1 1.33 1 1.534 1 1.451 1 1.673 1 1.09 1 38 5.68 0 3 1159.9904 5.48 35.72 2334.92868

VFALDQK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

10 6 178557739;67190748

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.461 2 11.5 0.912 2 0.7 1.304 2 16.2 1.43 2 17 1.488 2 6.8 1.632 2 7.5 1.141 2 9.4 37 5.55 0 3 718.69299 4.24 25.13 2154.06443

VFAVSHGR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

4 5 47132549;16933542

N-Term(iTRAQ4plex) 1.177 4 3.6 0.855 4 23.5 1.038 4 12.6 1.178 4 6.1 1.129 4 10 1.394 4 6.9 1.121 4 7.4 36 3.94 0 3 494.91998 1.81 8.64 1482.7443

VFCQPWQR CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 6 1 119392081 N-Term(iTRAQ4plex); C3(Methylthio)

1.35 1 0.967 1 1.221 1 1.263 1 1.434 1 1.483 1 1.175 1 34 1 2 569.86847 -1.05 10.1 1138.72966

VFDLELHPACR PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 4 1 157653329 N-Term(iTRAQ4plex); C10(Methylthio)

1.188 1 0.889 1 1.08 1 1.214 1 1.165 1 1.31 1 1.078 1 31 0 2 526.7655 -11.55 17.4 1052.52373

VFIGINDLEK COLEC11 collectin-11 isoform j [Homo sapiens]

78989 NP_001242918 4 10 364502955 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.474 6 16.6 0.961 6 7.5 1.292 6 15.3 1.389 6 22.4 1.543 6 15.4 1.595 6 13.5 1.157 6 3.7 85 6.23 0 2 1016.9853 3.22 80.89 2032.9633

VFIGVNDLER COLEC10 collectin-10 precursor [Homo sapiens]

10584 NP_006429 2 1 256017186 N-Term(iTRAQ4plex) 1.638 2 13 1.166 2 1.4 1.662 2 19.1 1.426 2 17.7 1.882 2 9 1.615 2 7.6 1.133 2 10 60 3.42 0 2 647.88751 5.25 20.22 1294.76775

VFLDCCNYITELR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); C5(Methylthio); C6(Methylthio)

1.432 5 5.2 0.846 5 24.8 1.174 5 11.4 1.512 5 11.9 1.372 5 3.9 1.579 5 2 1.139 5 10 57 6.33 0 3 784.70099 -0.17 49.1 2352.08841

VFLDCCNYITELRR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 8 1 115298678 N-Term(iTRAQ4plex); C5(Methylthio); C6(Methylthio)

1.681 3 2.8 0.992 3 7.4 1.664 3 2.1 1.619 3 5.3 1.685 3 10.9 1.699 3 3.5 1.074 3 3.2 53 4.81 0 3 943.50739 3.65 60.11 1886.00406

VFQFLEK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 43 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.648 1 1.19 1 1.682 1 1.414 1 1.927 1 1.619 1 1.146 1 50 4.2 0 2 932.00336 -4.63 18.46 1862.99944

VFQYIDLHQDEFVQTLK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 4 1 21071039 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.383 1 0.905 1 1.215 1 1.342 1 1.421 1 1.569 1 1.169 1 31 4.36 0 3 1016.9853 3.22 80.89 2048.94376

VFSGDGK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 3 1 45580688 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.94 1 0.963 1 0.883 1 0.916 1 0.964 1 1 1 1.092 1 46 3.32 0 2 677.39709 0.75 36.17 1353.78691

VFSLAVNLIAIDSQVLCGAVK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 6 1 115298678 N-Term(iTRAQ4plex); C17(Methylthio); K21(iTRAQ4plex)

1.299 1 1.266 1 1.997 1 1.577 1 0.948 1 0.749 1 0.475 1 5.06 2 3 883.76703 -10.65 58.8 2649.28653

VFSLQWGEVK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 41 1 119392081 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.222 3 15.6 0.934 3 11 1.133 3 0.9 1.214 3 10.1 1.155 3 55.4 1.332 3 10.8 1.025 3 56.6 85 7.93 0 3 973.52527 -1.48 79.02 2918.56125

VFSNGADLSGVTEEAPLK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 8 1 189163538 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.101 2 9.6 0.944 2 2.3 1.081 2 13.8 1.145 2 16.2 1.058 2 3.1 1.121 2 5.4 0.979 2 10.7 72 5.15 0 3 971.5094 3.94 63.56 1942.01152

VGALGFLALPGNPEAPGNMGLFDQQLALQWVQK

BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 2 1 4557351 N-Term(iTRAQ4plex); K33(iTRAQ4plex)

1.151 1 1.065 1 1.09 1 1.024 1 1.286 1 1.208 1 1.179 1 66 7.63 0 3 776.74615 -2.27 43.36 2328.22391

VGATSFYSTCQSNGK C1S complement C1s subcomponent precursor [Homo sapiens]

716 NP_958850 4 1 41393602 N-Term(iTRAQ4plex); C10(Methylthio); K15(iTRAQ4plex)

1.196 1 0.963 1 1.093 1 1.136 1 1.254 1 1.303 1 1.147 1 64 4.69 0 2 1001.4606 -6.55 26.21 2001.91399

VGCDNTVVR CRHBP corticotropin-releasing factor-binding protein precursor [Homo sapiens]

1393 NP_001873 2 1 47080099 N-Term(iTRAQ4plex); C3(Methylthio)

1.048 1 0.872 1 0.909 1 1.042 1 1.053 1 1.207 1 1.159 1 39 3.64 0 2 732.41235 3.18 63.01 1463.81743

VGDTLNLNLR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

86 6 178557739;67190748

N-Term(iTRAQ4plex) 0.898 1 0.895 1 0.823 1 0.92 1 0.879 1 0.981 1 1.067 1 32 4.43 0 3 510.92148 -4.68 16.98 1530.74988

VGDTYERPK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

9 6 47132549;16933542

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.108 1 1.012 1 1.036 1 1.024 1 1.193 1 1.18 1 1.152 1 3.15 0 2 576.82104 -2.88 32.05 1152.63481

VGEVLNSIFFELEADER AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 38 1 4557287 N-Term(iTRAQ4plex) 1.125 14 14.3 0.928 14 13.2 0.985 14 17.6 1.1 14 7.7 1.122 14 17.4 1.257 14 16.2 1.146 14 10.4 108 5.94 0 2 1055.9873 -1.02 50.11 2110.96733

VGEYSLYIGR APCS serum amyloid P-component precursor [Homo sapiens]

325 NP_001630 35 1 4502133 N-Term(iTRAQ4plex) 1.113 17 6.7 0.937 17 13.7 1.01 17 13.7 1.076 17 8.9 1.173 17 9 1.218 17 13.1 1.135 17 4.9 96 6 0 2 850.38513 -1.15 39.15 1699.76335

VGFYESDVMGR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 14 1 66932947 N-Term(iTRAQ4plex) 1.196 67 31.5 0.942 67 45.1 1.173 67 36.5 1.179 67 42.9 1.265 67 39.6 1.298 67 39.5 1.048 67 47 95 9.37 0 4 1049.453 3.56 82.75 3146.34446

VGFYESDVMGR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 3 1 66932947 N-Term(iTRAQ4plex); M9(Oxidation)

1.211 15 10.4 0.962 15 8.1 1.117 15 17.8 1.192 15 15.4 1.25 15 16.5 1.274 15 12.2 1.075 15 14.5 93 6.28 0 3 921.10773 -1.68 65.01 2761.31449

VGLIHDVFQLVGAGR ERAP2 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]

64167 NP_001123612 2 1 194306629 N-Term(iTRAQ4plex) 1.4 27 21.2 1.051 25 25.2 1.337 27 19.2 1.252 25 32.9 1.293 27 15.6 1.371 26 32.1 0.946 27 22.1 93 8.11 0 3 1009.4915 4.54 48.19 3026.45523

VGLSDAFVVVHR PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 4 1 40255005 N-Term(iTRAQ4plex) 1.021 7 9.1 0.931 7 20.5 0.919 7 9.5 1.015 7 13.8 1.088 7 18 1.162 7 8.5 1.115 7 9.2 92 12.56 0 4 1098.1832 -1.03 56.39 3292.55092

VGLSGMAIADVTLLSGFHALR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

641 4 178557739;67190748

N-Term(iTRAQ4plex) 1.06 16 10 0.978 16 12.9 0.981 16 13 0.993 16 5.5 1.087 16 12.2 1.087 16 9.7 1.1 16 7 91 5.18 0 3 900.95599 2.26 47.36 1800.90471

VGLSGMAIADVTLLSGFHALR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

243 4 178557739;67190748

N-Term(iTRAQ4plex); M6(Oxidation)

1.183 15 13 0.96 15 17.9 1.123 15 20 1.114 15 10.2 1.277 15 12.2 1.239 15 24.7 1.058 15 14.8 90 5.95 0 3 1067.5055 -7.07 35.23 2134.01712

VGSALFLSHNLK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 8 1 21361302 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.879 6 22.5 0.956 6 21 0.751 6 37.1 0.877 6 24.3 0.948 6 33 1.046 6 11.8 1.16 6 8.5 82 4.96 0 2 783.90198 -6.98 17.29 1566.79668

VGSDSVQCYQFGWSPNFPTCK

CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 6 1 13540563 N-Term(iTRAQ4plex); C8(Methylthio); C20(Methylthio); K21(iTRAQ4plex)

0.802 1 0.816 1 0.734 1 0.899 1 0.722 1 0.885 1 0.984 1 80 7.59 0 3 749.35846 6.17 43.97 2246.06083

VGSPNAAVLWLWSSHNR QSOX1 sulfhydryl oxidase 1 isoform a precursor [Homo sapiens]

5768 NP_002817 NP_689875

4 2 13325075 N-Term(iTRAQ4plex) 1.012 14 2.1 0.982 14 5.3 0.916 14 6.6 0.985 14 7 1.05 14 4.1 1.088 14 7.2 1.129 14 5.8 78 5.14 0 2 891.45056 -0.55 76.31 1781.89385

VGYVSGWGR HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 27 2 4826762 N-Term(iTRAQ4plex) 1.265 10 10.9 0.99 10 7.7 1.182 10 18.7 1.265 10 10.5 1.3 10 18.4 1.372 10 12.5 1.097 10 14.9 76 7.45 0 3 1199.6346 4.01 57.48 2398.26201

VHANPLLIDVVTYLVALIPEPSAQQLR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 36 1 105990532 N-Term(iTRAQ4plex) 1.175 6 54.7 1.142 6 50.6 1.395 6 70 1.295 6 30.9 1.218 5 24.2 1.021 5 33.9 1.065 4 8.6 73 7.46 0 3 1258.6726 -0.03 57.19 3774.00327

VHDVNDNWPVFTHR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 3 1 166362713 N-Term(iTRAQ4plex) 1.168 15 16.5 0.941 15 23.7 1.082 15 19.4 1.106 15 7.7 1.183 15 18.5 1.206 15 15.7 1.127 15 5.5 72 5.87 0 3 903.46576 -2.16 34.9 1805.92424

VHFLPVVISDNGMPSR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 4 1 166362713 N-Term(iTRAQ4plex) 1.669 2 11.8 0.904 2 10.3 1.476 2 10.9 1.633 2 21.4 1.703 2 3.3 1.883 2 13.7 1.153 2 7.5 68 7.73 0 3 749.35846 6.17 43.97 2262.03733

VHFLPVVISDNGMPSR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 2 1 166362713 N-Term(iTRAQ4plex); M13(Oxidation)

1.21 1 0.795 1 1.008 1 1.268 1 1.163 1 1.464 1 1.154 1 66 0 2 783.90198 -6.98 17.29 1582.80425

VHIQSSQTVESSGLYTLQSILK

MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 4 1 71274107 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.224 10 14 1.007 10 16.4 1.206 10 18.2 1.158 10 7.6 1.354 10 15.1 1.251 10 10.4 1.118 10 4.3 64 4.34 0 2 719.42279 2.69 43.96 1437.83782

VHQYFNVELIQPGAVK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 9 1 115298678 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.314 4 2.5 0.761 4 3.8 1.076 4 4.8 1.381 4 1.4 1.261 4 1 1.622 4 4 1.154 4 3.9 56 6.13 0 3 655.33112 3.55 81.93 1963.97879

VHYTVCIWR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

29 4 178557739;67190748

N-Term(iTRAQ4plex); C6(Methylthio)

1.088 19 12.5 1.061 19 7.7 1.006 19 26.5 1.023 19 16.8 1.156 19 19.5 1.145 19 17.9 1.119 19 3.5 55 3.14 0 2 601.29626 -7.95 25.49 1201.58525

VIDQFGE F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 1 1 4503635 N-Term(iTRAQ4plex) 0.665 3 4.8 1.034 3 5.9 0.714 3 9.8 0.664 3 15.7 0.776 3 16.9 0.813 3 4.9 1.14 3 30.6 52 6.3 0 3 655.33112 3.55 81.93 1947.97904

VIEHIMEDLDTNADK S100A9 protein S100-A9 [Homo sapiens] 6280 NP_002956 6 1 4506773 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.116 15 13.3 1.027 15 13.9 1.121 15 23.6 1.048 15 7 1.237 15 20.9 1.151 15 5.8 1.138 15 3.3 47 3.62 0 2 647.82428 -0.1 31.05 1294.63786

VIGNMGQTMEQLTPELK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 21 1 105990532 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

2.536 1 1.044 1 2.777 1 2.659 1 2.408 1 2.305 1 0.867 1 46 5.72 0 3 749.35846 6.17 43.97 2278.02243

VIGNMGQTMEQLTPELK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 10 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); K17(iTRAQ4plex)

1.091 3 10.1 1.054 3 11.7 1.06 3 21 1.02 3 2.1 1.182 3 22.1 1.128 3 1 1.115 3 0.4 46 3.61 0 3 410.21255 -0.29 14.09 1228.62311

VIGNMGQTMEQLTPELK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); M5(Oxidation); M9(Oxidation); K17(iTRAQ4plex)

1.131 6 9.8 0.997 6 19 1.07 6 16.5 1.058 6 8.9 1.27 6 7.9 1.214 6 5.8 1.161 6 5.6 45 4.92 0 3 920.94287 7.83 25.52 1840.88156

VIGSGCNLDSAR LDHA;LDHB L-lactate dehydrogenase A chain isoform 2 [Homo sapiens];L-lactate dehydrogenase B chain [Homo sapiens]

3939;3945 NP_001128711;NP_002291

2 8 207028494;4557032

N-Term(iTRAQ4plex); C6(Methylthio)

1.056 2 4.5 0.968 2 14.8 0.996 2 11.4 1.029 2 3.3 1.085 2 12.1 1.12 2 2.7 1.088 2 0.6 42 2.89 0 2 578.34839 2.72 17.19 1155.67876

VIGTLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.147 2 6.2 0.922 2 7.2 1.042 2 2.3 1.13 2 9.5 1.164 2 3.1 1.262 2 10.3 1.117 2 0.8 33 0 2 410.21255 -0.29 14.09 1244.6176

VIHDNFGIVEGLMTTVHAITATQK

GAPDH glyceraldehyde-3-phosphate dehydrogenase isoform 2 [Homo sapiens]

2597 NP_001243728 1 2 378404908 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.057 1 1.082 1 1.043 1 0.964 1 1.159 1 1.071 1 1.112 1 33 0 2 452.29834 3.11 11.39 903.5894

VILGAHQEVNLEPHVQEIEVSR

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 206 1 4505881 N-Term(iTRAQ4plex) 1.076 3 0.5 0.838 3 4.1 0.931 3 3.8 1.111 3 0.3 1.045 3 3.4 1.219 3 5.9 1.097 3 3.1 33 3.12 0 3 372.86957 2.07 12.85 1116.59415

VINLPLDSMAAPWETGDTFPDVVAIAPDVR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 9 1 156616294 N-Term(iTRAQ4plex); M9(Oxidation)

1.156 1 0.968 1 1.059 1 1.094 1 1.215 1 1.256 1 1.148 1 32 2.92 0 2 562.3078 5.08 18.17 1123.60832

VINLPLDSMAAPWETGDTFPDVVAIAPDVR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 20 1 156616294 N-Term(iTRAQ4plex) 0.806 2 1.9 0.89 2 23.2 0.745 2 10.6 0.838 2 12.4 0.782 2 14.8 0.879 2 8.2 1.049 2 4.1 4.84 0 3 673.67676 -4.65 33.51 2019.01572

VIPACLPSPNYVVADR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 19 1 4505881 N-Term(iTRAQ4plex); C5(Methylthio)

1.618 1 1.229 1 1.915 1 1.559 1 1.691 1 1.376 1 0.883 1 3.77 0 4 892.67358 -5.36 50.58 3567.67251

VIPGPPALTLVPAELVR CSF1R macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens]

1436 NP_005202 4 1 27262659 N-Term(iTRAQ4plex) 44 3.5 0 2 480.2739 1.46 15.27 959.54039

VIQLGTLVDNLTVDPATGDILAGCHPNPMK

PON3 serum paraoxonase/lactonase 3 [Homo sapiens]

5446 NP_000931 2 1 29788996 N-Term(iTRAQ4plex); C24(Methylthio); K30(iTRAQ4plex)

1.412 1 0.903 1 1.277 1 1.415 1 1.41 1 1.562 1 1.104 1 95 4.64 0 2 783.95807 -0.35 37.92 1566.90886

VISLLPK PEBP4 phosphatidylethanolamine-binding protein 4 precursor [Homo sapiens]

157310 NP_659399 2 1 116812622 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.345 1 0.923 1 1.2 1 1.3 1 1.386 1 1.502 1 1.155 1 81 6.24 0 2 900.41785 -1.84 20.93 1799.82842

VISTITNNIQQIIEIEDTFETLR TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex) 1.304 2 4.8 0.905 2 12 1.141 2 1.6 1.26 2 13.6 1.345 2 3 1.486 2 8.9 1.18 2 4.6 71 6.93 0 3 610.63788 2.81 28.7 1829.89908

VIVIPVGIGPHANLK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 8 1 89191868 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.326 3 1.1 0.93 3 6 1.177 3 6.2 1.317 3 2.4 1.407 3 0.4 1.492 3 2.5 1.133 3 8.9 67 6.86 0 3 976.51123 0.22 47.23 1952.01688

VIVVSMNYR BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 8 1 4557351 N-Term(iTRAQ4plex) 1.398 2 5.5 0.938 2 35.3 1.235 2 23.4 1.317 2 11.1 1.492 2 21.5 1.591 2 13.1 1.208 2 1.9 66 5.87 0 3 722.38678 2.54 70.31 2165.14579

VKDISEVVTPR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 7 1 67782358 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

2.25 1 0.925 1 2.103 1 2.273 1 2.23 1 2.41 1 1.061 1 61 5.24 0 3 653.0592 -6.9 65.83 1957.16306

VKEEVFIQQR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 1 1 89191868 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.478 1 0.976 1 1.408 1 1.442 1 1.514 1 1.55 1 1.075 1 37 5.4 0 3 635.6532 0.22 43.34 1904.94504

VKHLIDSLIDFLNFPR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.31 1 0.905 1 1.185 1 1.309 1 1.311 1 1.448 1 1.106 1 29 0 2 590.29132 -2.3 24.81 1179.57536

VKSPELQAEAK APOA2 apolipoprotein A-II preproprotein [Homo sapiens]

336 NP_001634 2 1 4502149 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K11(iTRAQ4plex)

1.252 1 0.883 1 1.1 1 1.245 1 1.258 1 1.424 1 1.144 1 46 3.36 0 2 705.90839 1.52 35.84 1410.8095

VKVEPLYELVTATDFAYSSTVR

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 32 1 4557391 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

2.021 7 13.2 0.914 7 18.4 1.831 7 6.1 1.876 7 20.7 2.02 7 11.7 2.176 7 25.1 1.149 7 16 118 6.59 0 3 1127.5909 -2.23 30.11 2254.18155

VKWYLFGMGNEVDVHAAFFHGQALTNK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 3 1 4557485 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K27(iTRAQ4plex)

2.201 5 2.2 0.905 5 17.5 1.924 5 7.9 2.269 5 5.7 2.132 5 4.6 2.509 5 9.8 1.101 5 3.6 110 5.58 0 2 1067.1283 3.89 52.73 2133.24614

VLAQLLR CD93 complement component C1q receptor precursor [Homo sapiens]

22918 NP_036204 1 2 88758613 N-Term(iTRAQ4plex) 2.038 11 20.8 1.022 11 15.7 1.897 11 26.9 1.929 11 14.3 2.07 11 29 2.251 11 20.5 1.153 11 1.8 104 5.92 0 2 947.02393 -3.56 40.95 1893.04057

VLATLCGQESTDTER MASP2 mannan-binding lectin serine protease 2 isoform 2 precursor [Homo sapiens]

10747 NP_631947 4 2 21264361 N-Term(iTRAQ4plex); C6(Methylthio)

1.963 11 19.5 0.977 11 13.4 1.932 11 20.5 1.899 11 20 2.055 11 20.1 2.109 11 23.9 1.066 11 6 101 5.15 0 2 808.40808 -7.82 50.58 1615.81536

VLDELTLAR KRT16;KRT14;KRT19

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens];keratin, type I cytoskeletal 19 [Homo sapiens]

3868;3861;3880

NP_005548;NP_000517;NP_002267

2 5 24430192;15431310;24234699

N-Term(iTRAQ4plex) 1.772 4 7.3 0.969 4 24 1.602 4 10.6 1.747 4 17.6 1.869 4 14.5 2.063 4 10.3 1.166 4 1.9 101 10.15 0 3 892.46747 -4.24 34.97 2675.38785

VLDELTLTK KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

12 3 195972866 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.964 5 25.1 0.909 5 13.9 1.619 5 32.6 1.954 5 19.1 1.972 5 30.4 2.382 5 19.8 1.194 5 3.1 98 7.05 0 3 1337.6697 4.71 50.91 2674.33023

VLDINDNEPVFTQDVFVGSVEELSAAHTLVMK

DSG2 desmoglein-2 preproprotein [Homo sapiens]

1829 NP_001934 2 1 116534898 N-Term(iTRAQ4plex); K32(iTRAQ4plex)

1.858 12 15.6 0.895 12 5.5 1.651 12 15.4 1.819 12 9 1.838 12 18.7 2.038 12 19.9 1.103 12 7.4 95 8.5 0 3 1103.9996 -3.05 35.48 2206.9937

VLDLSCNR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 4 1 4557417 N-Term(iTRAQ4plex); C6(Methylthio)

2.154 2 11.2 0.966 2 10.3 2.002 2 6 2.074 2 16.3 2.235 2 6.2 2.314 2 16.5 1.116 2 0.2 93 4.48 0 2 876.92328 -1.97 46.61 1752.83928

VLELSESHPDSGEQTVR PDGFRB platelet-derived growth factor receptor beta precursor [Homo sapiens]

5159 NP_002600 2 1 4505683 N-Term(iTRAQ4plex) 1.85 2 6 0.745 2 27.6 1.496 2 16.3 2.007 2 10.9 1.745 2 19 2.341 2 8.3 1.166 2 2.6 93 4.54 0 2 711.89899 2.93 17.44 1422.77641

VLEMTGNIDEAEWEWK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 10 1 4557351 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.927 9 5.1 0.898 9 4.5 1.699 9 11.9 1.734 9 14.5 1.917 9 7.1 1.986 9 15.2 1.151 9 5.4 91 5.75 0 2 916.47809 -2.6 38.56 1831.94756

VLEPTLK GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 11 2 32483410 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.545 2 12.7 0.957 2 1.3 1.379 2 16.6 1.441 2 18 1.644 2 8.3 1.718 2 9.6 1.192 2 8.2 90 4.66 0 2 900.48816 -2.86 29.11 1799.96294

VLEYLNDLK MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 5 2 19923761 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.38 3 21.9 1.109 3 26.8 2.188 3 30.8 2.21 3 9.5 2.402 3 59.8 2.461 3 7.4 1.098 3 2.1 89 5.97 0 3 1167.1588 3.17 51.96 2333.31296

VLFETDLVNPR NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 4 1 115298674 N-Term(iTRAQ4plex) 2.119 3 24.6 0.882 3 7.9 1.866 3 16.5 2.005 3 43.4 2.225 3 9.4 2.391 3 35.6 1.176 3 2.1 88 7.63 0 3 1186.4627 0.07 23.7 2371.91947

VLFYVDSEK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 28 1 45580688 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.051 3 18.9 0.938 3 3.1 1.845 3 16.3 1.966 3 19.5 2.131 3 18.2 2.271 3 21.4 1.155 3 1.9 87 5.8 0 3 927.51874 -3.35 55.1 1854.03055

VLGPFCGEK MASP1;MASP1;MASP1

mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens];mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648;5648;5648

NP_001027019;NP_001027019;NP_001027019

8 3 21264359;73623026;21264357

N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

2.306 7 15.6 0.95 7 4.4 2.038 7 13.5 2.217 7 8.6 2.331 7 17.3 2.445 7 9.7 1.119 7 3.2 86 5.86 0 2 876.92328 -1.97 46.61 1736.84636

VLGQVNK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 2 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.814 7 20.1 0.951 7 17.5 1.714 7 25 1.623 7 13.9 1.994 7 18.6 1.784 7 6.6 1.099 7 7.2 84 5.08 0 2 993.52246 -4.04 36.83 1986.03765

VLHGDLIDFVCK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 15 1 110611237 N-Term(iTRAQ4plex); C11(Methylthio); K12(iTRAQ4plex)

2.049 7 11.6 0.988 7 13 1.704 7 8.2 1.959 7 24.9 2.079 7 11.3 2.282 7 24.1 1.165 7 7.2 84 5.77 0 2 1069.0425 -3.18 41.39 2137.08745

VLKDQVNTFDNIFIAPVGISTAMGMISLGLK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 2 1 73858566 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K31(iTRAQ4plex)

1.767 3 11.4 0.991 3 14.2 1.526 3 13.6 1.801 3 14.3 1.63 3 2.7 1.857 3 16.9 1.049 3 2.5 82 4.62 0 2 953.53473 5.11 22.59 1906.06084

VLKDQVNTFDNIFIAPVGISTAMGMISLGLK

SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 3 1 73858566 N-Term(iTRAQ4plex); K3(iTRAQ4plex); M25(Oxidation); K31(iTRAQ4plex)

2.568 3 2.7 1.232 3 1.9 2.303 3 1 2.248 3 17.2 2.699 3 14.1 2.378 3 27.8 1.058 3 0 80 6.68 0 3 1106.6638 1.73 30.96 2212.3187

VLLAPLGDDFR MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 2 1 51477714 N-Term(iTRAQ4plex) 1.806 6 21.7 0.934 6 31.5 1.707 6 15.2 1.826 6 38.5 1.915 6 8.4 1.851 6 33.8 1.065 6 10.3 80 7.39 0 3 844.79675 0.99 80.23 2532.37442

VLLDGVQNPR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 6 1 115298678 N-Term(iTRAQ4plex) 2.078 6 13.6 0.977 6 12.4 1.929 6 5.9 2.031 6 20.8 2.14 6 8.6 2.326 6 19 1.109 6 6.7 80 6.78 0 3 1086.6303 0.6 57.59 2172.25431

VLLDQLGTTISFER APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex) 1.588 1 0.62 1 1.225 1 1.974 1 1.349 1 2.175 1 1.102 1 80 4.06 0 2 702.90338 -6.74 17.95 1404.79949

VLLESIGSHEELTQDSR PTPRJ receptor-type tyrosine-protein phosphatase eta isoform 2 precursor [Homo sapiens]

5795 NP_001091973 6 2 148728160 N-Term(iTRAQ4plex) 2.117 5 5.1 1.035 5 3.5 2.005 5 15.7 1.925 5 17.9 2.279 5 10.5 2.191 5 11.3 1.137 5 3 79 5.68 0 2 841.9425 -3.72 22.62 1682.87773

VLMSVLNDNSR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 10 2 14550407 N-Term(iTRAQ4plex) 1.631 1 1.113 1 1.355 1 1.217 1 2.091 1 1.879 1 1.543 1 77 7.22 0 3 769.76947 4.71 77.51 2307.29386

VLMSVLNDNSR C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 6 2 14550407 N-Term(iTRAQ4plex); M3(Oxidation)

1.828 3 2.7 0.859 3 3.2 1.563 3 6 1.861 3 9.3 1.896 3 12.9 2.209 3 9.7 1.172 3 7.8 74 5.7 0 3 1212.533 0.88 38.02 2424.0549

VLNILEK NIPBL nipped-B-like protein isoform B [Homo sapiens]

25836 NP_056199 1 2 47578107 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.463 2 75.4 0.849 2 19.9 2.101 2 78.3 2.474 2 52.6 2.46 2 98.2 2.896 2 69 1.171 2 13 70 9.17 0 3 1122.6148 1.71 48.32 3365.82969

VLNYVDWIK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

16 1 66347875 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.963 6 15.5 0.977 6 9.6 1.734 6 20.7 1.905 6 11.4 2.01 6 19.9 2.224 6 11.2 1.132 6 6.1 65 4.73 0 2 768.93799 -3.36 54.81 1536.87517

VLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLR

CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

3 1 256217721 N-Term(iTRAQ4plex); C12(Methylthio)

2.541 4 20.7 0.944 4 4.4 2.391 4 23 2.566 4 11.1 2.55 4 25.2 2.7 4 12.1 1.067 4 3.1 64 7.18 0 3 1103.9996 -3.05 35.48 2222.98917

VLPDPEVISDLVFLK NEO1 neogenin isoform 2 precursor [Homo sapiens]

4756 NP_001166094 2 3 290656011 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.289 26 13.6 0.818 26 39.1 2.034 26 36.7 2.187 26 25.2 2.36 26 25.6 2.616 26 19.1 1.142 26 21.1 62 7.97 0 3 1033.5582 4.05 61.36 3098.66013

VLQIEK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

1 6 178557739;67190748

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

2.114 10 3.7 0.916 10 6.5 1.863 10 12.8 2.068 10 14.5 2.106 10 11.9 2.274 10 14.6 1.087 10 6.1 62 6.78 0 3 981.03516 0.38 34.81 1961.06614

VLSALQAVQGLLVAQGR AGT angiotensinogen preproprotein [Homo sapiens]

183 NP_000020 104 1 4557287 N-Term(iTRAQ4plex) 2.458 8 8.7 1.071 8 15.1 2.409 8 15.4 2.26 8 3.1 2.681 8 17.1 2.538 8 4 1.123 8 1.5 62 4.87 0 2 751.86542 0.91 30.96 1502.72356

VLSIAQAHSPAFSCEQVR CD14 monocyte differentiation antigen CD14 precursor [Homo sapiens]

929 NP_000582 18 1 4557417 N-Term(iTRAQ4plex); C14(Methylthio)

2.234 5 16.7 0.96 5 37.4 2.064 5 48.2 2.291 5 9.5 2.222 5 34.4 2.412 5 9.6 1.122 5 20.9 62 9.03 0 3 1122.6148 1.71 48.32 3349.827

VLSLAQEQVGGSPEK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

129 6 178557739;67190748

N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.702 1 0.775 1 1.519 1 1.959 1 1.504 1 1.939 1 0.99 1 60 6.93 0 3 861.76306 1.24 51.08 2583.27463

VLSYVDWIK C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 8 1 289547636 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.91 3 5.1 0.974 3 9.4 1.643 3 3.3 1.817 3 8.7 1.897 3 18.3 2.067 3 10.9 1.138 3 2.1 59 4.21 0 2 703.37634 2.95 36.74 1405.74077

VLTGNPR SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 3 1 39725934 N-Term(iTRAQ4plex) 1.98 11 20.3 0.922 11 21.7 2.177 11 39.9 1.826 11 42 2.303 10 19.5 2.299 10 18.3 1.12 10 23 57 8.39 1 3 1195.6201 2.12 57.17 3584.85459

Page 42: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

VLTPDAFVCR KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 6 1 78191798 N-Term(iTRAQ4plex); C9(Methylthio)

1.587 2 25.5 0.961 2 43.9 1.443 2 59.5 1.502 2 13.1 1.696 2 39 1.765 2 4.4 1.175 2 17.6 57 5.12 0 3 942.42188 -1.92 65.82 2825.25583

VLTPPMGTVMDVLK TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.993 3 21.7 0.952 3 5.3 1.934 3 12.4 2.106 3 7 1.966 3 6 2.057 3 24.6 1.139 3 13.3 55 6.16 1 4 1242.7697 7.43 26.14 2484.53066

VLVDHFGYTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.514 1 0.909 1 1.329 1 1.462 1 1.561 1 1.716 1 1.174 1 54 6.87 1 3 670.71661 -1.12 46.75 2010.13529

VLYDAEISQIHQSVTDTNVILSMDNSR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); M23(Oxidation)

2.252 5 3.5 0.976 5 6.4 2.046 5 17.4 2.075 5 14.4 2.267 5 17.6 2.255 5 13.7 1.13 5 3.3 54 4.48 0 2 700.37256 -5.15 33.28 1399.7553

VLYDAEISQIHQSVTDTNVILSMDNSR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 1 2 47132620 N-Term(iTRAQ4plex) 1.732 7 12.9 0.947 7 5.1 1.596 7 22.3 1.674 7 13.9 1.801 7 17.6 1.876 7 3.8 1.128 7 5 54 4.48 0 2 702.34149 0.77 42.97 1403.67217

VMAVDALASSHPLSTPASEINTPAQISELFDAISYSK

ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 N-Term(iTRAQ4plex); K37(iTRAQ4plex)

1.769 7 10.6 0.924 7 9.8 1.625 7 23 1.694 7 5.9 1.885 7 18.7 1.985 7 5.3 1.128 7 2.2 54 3.16 0 2 677.8772 1.74 32.79 1354.74858

VMDKYTFELSR GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 1 2 32483410 N-Term(iTRAQ4plex); K4(iTRAQ4plex)

1.83 2 4.3 0.671 2 67.2 1.476 2 30 2.2 2 32.5 1.645 2 29 2.451 2 33.5 1.114 2 0.9 52 8.57 0 3 918.13837 2.76 71.45 2752.40055

VMNHICSK AFM afamin precursor [Homo sapiens] 173 NP_001124 1 1 4501987 N-Term(iTRAQ4plex); M2(Oxidation); C6(Methylthio); K8(iTRAQ4plex)

1.243 1 0.942 1 1.019 1 1.081 1 1.396 1 1.482 1 1.371 1 52 4.93 0 3 1167.1588 3.17 51.96 2349.30448

VMPICLPSK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 67 3 4826762 N-Term(iTRAQ4plex); C5(Methylthio); K9(iTRAQ4plex)

1.774 3 26.8 0.836 3 11.1 1.465 3 37.4 1.888 3 7.8 1.685 3 44.9 2.171 3 2.6 1.11 3 3.1 50 4.87 1 3 603.69604 1.49 42.97 1809.06937

VMSISIR CSF1R macrophage colony-stimulating factor 1 receptor precursor [Homo sapiens]

1436 NP_005202 1 1 27262659 N-Term(iTRAQ4plex) 2.368 1 1.023 1 2.174 1 2.125 1 2.616 1 2.557 1 1.203 1 49 2.78 0 2 486.78354 0.31 26.56 972.5598

VMTPAVYAPYDVK CHL1 neural cell adhesion molecule L1-like protein isoform 3 precursor [Homo sapiens]

10752 NP_001240317 2 3 358438315 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.071 4 13.5 0.975 4 5 1.789 4 20.4 2.069 4 13.2 2.08 4 20.8 2.405 4 3.8 1.12 4 3.9 49 3.54 0 2 667.89655 -4.82 24.8 1334.79241

VMVTDFENVPEEDGTR PCSK9 proprotein convertase subtilisin/kexin type 9 preproprotein [Homo sapiens]

255738 NP_777596 2 1 31317307 N-Term(iTRAQ4plex) 1.245 1 1.107 1 1.244 1 1.125 1 1.378 1 1.246 1 1.108 1 47 5.83 0 3 731.72284 0.28 25.41 2193.15396

VMYTQYEDESFTK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 6 1 105990535 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.574 2 12.3 0.99 2 7.6 2.407 2 8.9 2.431 2 16.7 2.718 2 8 2.745 2 15.7 1.129 2 0.9 45 2.87 0 2 702.34149 0.77 42.97 1419.66057

VNDAQEYR FETUB fetuin-B precursor [Homo sapiens] 26998 NP_055190 6 1 58331240 N-Term(iTRAQ4plex) 2.255 2 15.4 0.842 2 29.5 1.9 2 33.4 2.257 2 3.7 2.272 2 25.6 2.698 2 3.7 1.195 2 7.3 42 3.92 0 2 589.33667 -0.55 13.41 1177.66606

VNDDIIVNWVNETLR LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 6 1 167614506 N-Term(iTRAQ4plex) 2.095 1 0.764 1 1.728 1 2.262 1 1.967 1 2.575 1 1.138 1 41 3.39 0 2 575.78973 0.01 22.55 1150.57219VNDESTEGK APOB apolipoprotein B-100 precursor

[Homo sapiens]338 NP_000375 26 1 105990532 N-Term(iTRAQ4plex);

K9(iTRAQ4plex)1.884 2 3.5 0.987 2 23.4 1.784 2 5.7 1.808 2 17.5 1.97 2 10 1.996 2 13.1 1.104 2 4.3 40 5.69 0 3 563.96753 -9.51 16.29 1689.88803

VNIPLVTNEECQK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 21 1 78191798 N-Term(iTRAQ4plex); C11(Methylthio); K13(iTRAQ4plex)

1.978 3 1.3 1.019 3 0.5 1.907 3 7.2 1.782 3 2.9 2.103 3 1.6 2.048 3 1.1 1.091 3 0.1 39 0 2 478.27603 -0.35 10.52 955.54552

VNIVK RASGRP3 ras guanyl-releasing protein 3 isoform 2 [Homo sapiens]

25780 NP_056191 1 3 7662334 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.8 4 20 1.024 4 3.4 1.755 4 23.6 1.769 4 18.8 1.779 4 10.6 1.822 4 14 1.114 4 3.5 39 3.39 0 3 431.57956 0.7 48.52 1292.7238

VNKDDEEFIESNK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 167 1 4557485 N-Term(iTRAQ4plex); K3(iTRAQ4plex); K13(iTRAQ4plex)

1.674 1 0.943 1 1.515 1 1.606 1 1.738 1 1.843 1 1.148 1 38 5.31 1 3 882.04993 7.7 18.44 2644.13523

VNLSFDFPFYGHFLR PLXDC2 plexin domain-containing protein 2 precursor [Homo sapiens]

84898 NP_116201 2 1 40255005 N-Term(iTRAQ4plex) 2.612 3 9.3 1.227 3 8 2.69 3 7 2.178 3 15.1 3.084 3 4.3 2.451 3 23.5 1.125 3 2.8 6.63 0 3 1033.5582 4.05 61.36 3114.65769

VNQNLVYESGSLNFSK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 41 1 105990532 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.39 1 0.984 1 1.289 1 1.31 1 1.468 1 1.492 1 1.139 1 4.61 1 3 603.69604 1.49 42.97 1825.06638

VNSFFSTFK APOA4 apolipoprotein A-IV precursor [Homo sapiens]

337 NP_000473 26 1 71773110 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.218 1 0.876 1 1.879 1 2.145 1 2.282 1 2.606 1 1.215 1 3.93 0 3 768.93799 -3.36 54.81 1552.86673

VNSQSLSPYLFR SPP2 secreted phosphoprotein 24 precursor [Homo sapiens]

6694 NP_008875 4 1 5902118 N-Term(iTRAQ4plex) 89 6.27 0 2 890.50012 -3.74 48.92 1779.99187

VNVGDPK C2 complement C2 isoform 1 preproprotein [Homo sapiens]

717 NP_000054 2 3 14550407 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

50 3.67 0 2 653.90192 -0.58 29.54 1306.79387

VNWEEEAASGLLTSLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 170 1 105990532 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

49 5.02 0 3 925.05994 -11.89 24.98 1849.11362

VPAAK PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 2 1 156616294 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

37 0 2 506.81833 -9.86 16.01 1012.62938

VPAAYAASLCGLCGNYNQDPADDLK

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C10(Methylthio); C13(Methylthio); K25(iTRAQ4plex)

36 2.91 0 2 515.78058 9.75 27.99 1030.55388

VPAAYAGSLCGLCGNYNQDPADDLK

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C10(Methylthio); C13(Methylthio); K25(iTRAQ4plex)

1.828 7 43.1 0.862 7 26.2 1.885 7 21.7 1.953 7 44.4 1.423 7 42.2 1.72 7 41.3 1.019 7 18.2 99 8.97 0 3 1089.1875 3.18 54.22 3265.54685

VPANLENVGFEVQTAEDDLK

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 22 1 169636415 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.466 7 5.7 1.041 7 15.4 1.478 7 5.2 1.326 7 8.4 1.597 7 7.3 1.494 7 11.4 1.127 7 5.4 83 6.2 0 2 828.46472 -1.55 51.76 1655.92217

VPANLENVGFEVQTAEDDLKTDFYK

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 8 1 169636415 N-Term(iTRAQ4plex); K20(iTRAQ4plex); K25(iTRAQ4plex)

1.356 16 18.7 0.952 16 7.7 1.32 16 25 1.359 16 18.1 1.416 16 21.8 1.421 16 16.3 1.137 16 4.9 79 5.87 0 3 797.39386 -0.5 47.06 1593.78105

VPDEHMIPIENLMNPR LRP1 prolow-density lipoprotein receptor-related protein 1 precursor [Homo sapiens]

4035 NP_002323 1 1 126012562 N-Term(iTRAQ4plex) 1.519 1 1.102 1 1.559 1 1.415 1 1.634 1 1.483 1 1.048 1 71 4.48 0 2 797.39386 -0.5 47.06 1609.77959

VPGLYYFTYHASSR C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 4 1 87298828 N-Term(iTRAQ4plex) 2.587 4 39.5 1.031 4 21.4 2.461 4 37.3 2.428 4 42.8 2.772 4 35.8 2.73 4 41.6 1.116 4 5.2 50 3.44 0 2 577.33112 8.13 17.78 1153.65007

VPGTSTSATLTGLTR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

53 5 47132549;16933542

N-Term(iTRAQ4plex) 1.635 53 13.9 0.965 53 12.1 1.514 53 17.4 1.568 53 11.5 1.708 53 12.2 1.809 53 10.3 1.14 53 5.3 121 6.41 0 2 898.93341 -17.25 18.16 1796.88469

VPHDLDMLLR PLTP phospholipid transfer protein isoform c precursor [Homo sapiens]

5360 NP_001229849 2 4 339275807 N-Term(iTRAQ4plex) 2.069 26 21.4 0.959 26 10.6 1.948 26 25.1 1.947 26 22.2 2.222 26 26.3 2.256 26 14.1 1.137 26 6.6 105 9.35 0 3 1460.2634 0.2 45.38 2919.53042

VPLALFALNR PEPD xaa-Pro dipeptidase isoform 1 [Homo sapiens]

5184 NP_000276 NP_116041

2 3 149589008 N-Term(iTRAQ4plex) 1.723 31 32.2 0.955 31 13.7 1.533 31 29.8 1.589 31 20.7 1.802 31 53 1.853 31 33.3 1.087 31 18.3 100 9.18 0 3 1042.5596 -3.86 81.92 3125.66416

VPLDSSPATCHNNIMK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C10(Methylthio); K16(iTRAQ4plex)

2.085 13 7.5 0.973 13 11.2 1.906 13 7.9 2.042 13 11 2.138 13 17.4 2.278 13 13.3 1.115 13 8.3 98 7.45 0 3 1201.652 0.33 47.37 2402.29668

VPLDSSPATCHNNIMK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C10(Methylthio); M15(Oxidation); K16(iTRAQ4plex)

1.858 4 9.2 0.927 4 11 1.601 4 9.7 1.863 4 22.5 1.889 4 8.8 2.149 4 19.1 1.13 4 6 97 7.31 0 3 925.41626 2.38 38.49 2774.23661

VPLLLSEPINIIDALEMR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex) 1.5 110 9.6 0.966 110 14.5 1.363 110 15.4 1.432 110 14.9 1.535 110 10.8 1.594 110 14.5 1.123 110 10.8 95 6.51 0 3 1042.0691 -0.68 77.15 2083.13211

VPLLLSEPINIIDALEMR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 74 1 105990532 N-Term(iTRAQ4plex); M17(Oxidation)

1.581 36 7 0.965 36 9.8 1.455 36 9.1 1.571 36 5.6 1.612 36 8.7 1.742 36 8.9 1.123 36 7.6 95 5.22 0 2 1018.9457 1.11 41.23 2036.8842

VPMMLQDQEHHWYLHDR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 7 1 21361302 N-Term(iTRAQ4plex) 1.484 37 13.4 0.965 37 12.3 1.343 37 14.1 1.399 37 16.9 1.516 37 10.4 1.564 37 15.8 1.128 37 9.6 91 9.62 0 3 1460.2634 0.2 45.38 2903.52097

VPMMLQDQEHHWYLHDR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 8 1 21361302 N-Term(iTRAQ4plex); M3(Oxidation)

3.994 1 0.914 1 2.974 1 3.255 1 4.67 1 5.111 1 1.57 1 89 3.96 0 3 1242.8721 0.11 78.28 3726.60166

VPMMNSK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 6 1 73858568 N-Term(iTRAQ4plex); M4(Oxidation); K7(iTRAQ4plex)

1.686 35 27.2 0.89 34 15.1 1.413 35 35 1.606 34 30.8 1.718 35 32.5 1.955 34 15.1 1.206 35 33.1 84 7.69 0 4 1474.7274 1.08 61.55 2948.44756

VPPEWK FGA fibrinogen alpha chain isoform alpha-E preproprotein [Homo sapiens]

2243 NP_000499 1 2 4503689 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.871 9 12.4 0.927 9 8.4 1.702 9 22.2 1.773 9 18.3 1.803 9 12.1 2.064 9 3 1.078 9 7.1 79 6.94 1 3 801.77765 0.48 40.48 2403.31839

VPQTDMTFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); M6(Oxidation)

1.567 27 14 0.955 27 10.2 1.423 27 9.9 1.515 27 9.4 1.625 27 16.5 1.718 27 12.6 1.158 27 4.8 78 5.36 0 3 789.9162 1.83 17.56 1578.82549

VPQTDMTFR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 1 1 105990532 N-Term(iTRAQ4plex) 1.696 9 13.9 0.931 9 5 1.501 9 13.7 1.635 9 9.2 1.782 9 4.6 1.903 9 3.8 1.15 9 6.3 76 3.11 0 2 597.31506 4.83 43.58 1193.62285

VPSSYAEALCGLCGNFNGDPADDLALR

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C10(Methylthio); C13(Methylthio)

1.566 38 9.8 0.967 38 12.6 1.496 38 11.9 1.561 38 9.8 1.66 38 15 1.72 38 9.7 1.11 38 4.5 73 4.71 0 2 782.43195 -6.07 29.59 1563.85661

VPSYTLILPSLELPVLHVPR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 346 1 105990532 N-Term(iTRAQ4plex) 1.6 52 10.6 0.944 52 13.7 1.422 52 13.6 1.539 52 11 1.684 52 13.6 1.76 52 10.7 1.135 52 7.8 72 4.07 0 2 722.41833 -0.26 21.42 1443.82939

VPTADLEDVLPLAEDITNILSK

GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 132 2 32483410 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.827 59 11.2 0.955 59 13.5 1.663 59 16.7 1.71 59 11.4 1.9 59 16.3 1.957 59 11 1.144 59 7.9 70 5.09 0 3 711.04468 -0.34 48.37 2131.1171

VPTVEPLDSLTLFLFR ICAM2 intercellular adhesion molecule 2 precursor [Homo sapiens]

3384 NP_001093256 2 1 153082686 N-Term(iTRAQ4plex) 1.557 3 26.1 0.793 3 4.4 1.25 3 20.4 1.576 3 9.4 1.542 3 39.2 1.829 3 9.1 1.096 3 0.9 64 3.56 0 2 627.84302 -11.55 16.83 1254.70036

VPVAK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 1 5 205277383 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.953 2 18.5 0.921 2 24.5 1.785 2 34.2 1.938 2 9.1 1.978 2 27.4 2.148 2 2.7 1.108 2 6.3 64 6.54 0 3 564.29645 6.44 15.59 1690.87479

VPVAVQGEDTVQSLTQGDGVAK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 16 1 115298678 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

1.799 11 9.8 0.96 11 19.1 1.618 11 19.2 1.752 11 9.8 1.834 11 18.7 1.999 11 8.1 1.16 11 4.9 63 4.22 0 2 670.36182 -13.76 17.61 1339.73662

VPVER CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 N-Term(iTRAQ4plex) 1.662 5 9.5 0.989 5 10.4 1.625 5 5.8 1.664 5 7.8 1.843 5 2.8 1.802 5 17 1.1 5 5.6 61 4.78 0 2 684.39807 0.22 15.41 1367.78887

VQAAVGTSAAPVPSDNH APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 8 1 4557325 N-Term(iTRAQ4plex) 1.683 20 6 0.951 20 5.1 1.569 20 9.6 1.674 20 13.7 1.716 20 9.7 1.803 20 9.6 1.133 20 3.7 60 3.55 0 3 387.21921 -0.77 28.11 1159.6447

VQALEEANNDLENK KRT9 keratin, type I cytoskeletal 9 [Homo sapiens]

3857 NP_000217 9 2 55956899 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.582 10 7.2 0.854 10 13.1 1.411 10 8.3 1.644 10 13.1 1.514 10 12.8 1.738 10 13.6 1.089 10 3.1 58 4.96 0 3 500.56177 -2.13 17.45 1499.66997

VQEAHLTEDQIFYFPK C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 61 1 166197660 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.822 10 16.7 1.084 10 12.4 1.691 10 23.6 1.803 10 4.2 1.912 10 22.2 2.033 10 6.4 1.137 10 4.2 58 4.08 0 2 708.35516 -1.05 13.91 1415.70452

VQFELHYQEVK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 153 1 70778918 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.475 4 15.3 1.016 4 6.4 1.595 4 12.5 1.437 4 13.1 1.521 4 12.9 1.528 4 15.9 1.083 4 6.2 55 4.37 1 3 510.97455 -0.21 18.93 1530.90635

VQGNDHSATR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

8 2 31542984;262050538

N-Term(iTRAQ4plex) 1.535 40 9.6 1.046 40 11.3 1.491 40 14.6 1.457 40 12.1 1.678 40 10.9 1.57 40 12 1.088 40 9 54 5.96 0 3 1029.5931 0.52 67.7 2058.18877

VQGVEFSHR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 6 1 105990532 N-Term(iTRAQ4plex) 1.355 72 5.1 1.003 72 5.3 1.274 72 8.3 1.288 72 6.2 1.421 72 7.6 1.434 72 6.1 1.118 72 4.8 53 4.02 0 2 633.36304 -0.96 65.6 1265.71794

VQLSNDFDEYIMAIEQTIK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 54 1 115298678 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.637 4 9.3 1.03 4 12.7 1.578 4 7.1 1.601 4 4.1 1.7 4 8.5 1.773 4 3.6 1.088 4 3.1 52 3.66 0 2 652.84735 2.82 11.12 1304.68743

VQLSNDFDEYIMAIEQTIK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 8 1 115298678 N-Term(iTRAQ4plex); M12(Oxidation); K19(iTRAQ4plex)

3.101 2 10.3 0.924 2 0.4 2.843 2 7.3 3.078 2 7.7 3.122 2 12.7 3.38 2 13.1 1.098 2 5.3 51 8.17 0 3 1460.2634 0.2 45.38 2935.52341

VQLSPDLLATLPEPASPGR HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 8 1 4504383 N-Term(iTRAQ4plex) 1.393 27 6.6 0.945 27 10 1.302 27 10.8 1.348 27 8.4 1.476 27 7.9 1.552 27 6.8 1.135 27 4.5 51 5.66 0 3 749.02795 -1.14 40.54 2245.07114

VQLTGEPVPMAR PVR poliovirus receptor isoform gamma precursor [Homo sapiens]

5817 NP_001129241 2 4 209413730 N-Term(iTRAQ4plex) 1.741 109 6 0.936 109 10.1 1.585 109 9.6 1.695 109 6.8 1.775 109 8.4 1.925 109 6.8 1.133 109 4.2 50 3.19 0 2 555.34344 -1.15 26.99 1109.68254

VQLYDLGLQIHK LBP lipopolysaccharide-binding protein precursor [Homo sapiens]

3929 NP_004130 4 1 31652249 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.638 36 10.9 0.968 36 10.3 1.515 36 21.9 1.576 36 9.3 1.679 36 16.3 1.781 36 10.2 1.111 36 6.9 50 4.17 1 3 797.93121 -0.98 44.31 1594.85515

VQMLLNEK MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 2 2 19923761 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.708 10 10.5 0.928 10 5.6 1.525 10 13.4 1.623 10 12.5 1.753 10 11.7 1.843 10 13.6 1.162 10 10.1 45 4.72 1 4 526.29877 0.61 9.99 1576.881

VQNECPGITR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 5 1 4503011 N-Term(iTRAQ4plex); C5(Methylthio)

1.829 10 8.4 1.061 10 17.7 1.838 10 12.1 1.705 10 6.8 1.955 10 20 1.821 10 3.8 1.103 10 5.3 45 2.84 0 2 482.29016 1.76 11.03 963.57152

VQNTCK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 2 2 295054188 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

1.679 2 25.3 0.95 2 8.1 1.557 2 18.1 1.64 2 26.5 1.716 2 24 1.807 2 32.6 1.102 2 5.8 39 3.36 0 2 594.39056 2.02 14.41 1187.77385

VQPYLDDFQK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 5 1 4557321 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

0.946 1 0.828 1 0.758 1 0.915 1 0.972 1 1.174 1 1.282 1 37 5.58 1 4 592.59601 0.21 55.62 2367.3622

VQQPDCR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

7 6 178557739;67190748

N-Term(iTRAQ4plex); C6(Methylthio)

1.599 7 2.8 1.024 7 13.9 1.533 7 8 1.442 7 3.8 1.708 7 10.9 1.636 7 4.6 1.13 7 2.5 33 3.92 0 3 422.25952 1.9 13.14 1264.76401

VQQPDCREPFLSCCQFAESLR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

8 6 178557739;67190748

N-Term(iTRAQ4plex); C6(Methylthio); C13(Methylthio); C14(Methylthio)

1.497 3 2.5 1.105 3 1 1.595 3 3.2 1.443 3 14.6 1.65 3 0.3 1.485 3 8 1.013 3 5.5 32 4.42 1 3 537.98291 1.46 16.78 1611.91861

VQSTELCAGHLAGGTDSCQGDSGGPLVCFEK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 140 1 4505881 N-Term(iTRAQ4plex); C7(Methylthio); C18(Methylthio); C28(Methylthio); K31(iTRAQ4plex)

1.538 2 0.6 0.792 2 21.7 1.274 2 11.5 1.609 2 10 1.489 2 6.6 1.88 2 14.9 1.169 2 4.9 32 0 2 470.29407 5.87 14.83 939.58086

VQSTITSR ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 16 1 70778918 N-Term(iTRAQ4plex) 1.872 6 11.8 1.071 6 16.8 1.864 6 24.2 1.782 6 4 2.014 6 26.6 2.003 6 5.3 1.113 6 6.2 30 1 2 606.38849 -2.21 13.25 1211.7697

VQTAHFK C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 1 1 4557389 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.781 1 1.098 1 0.828 1 0.754 1 0.81 1 0.738 1 0.979 1 4.49 1 3 513.3111 1.1 26.23 1537.91874

VQVLLGAHSLSQPEPSK CFD complement factor D preproprotein [Homo sapiens]

1675 NP_001919 7 1 42544239 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.196 114 7.6 0.957 114 10.3 1.093 114 12.5 1.158 114 11.1 1.237 114 12 1.285 114 11.4 1.124 114 7.1 107 5.81 0 2 969.53979 2.51 65.01 1938.06963

VQVTSQEYSAR CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 4 2 28373119 N-Term(iTRAQ4plex) 1.217 12 10.6 1.046 12 9.8 1.199 12 15.8 1.157 12 6 1.315 12 17.4 1.302 12 12 1.112 12 7.7 100 6.08 0 2 821.44043 3.01 18.39 1641.87358

VQVVAGK KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

19 3 4504893;156231037

N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.202 34 6.2 0.991 34 10.3 1.13 34 8.7 1.154 34 9.6 1.254 34 7.5 1.32 34 7.4 1.123 34 4.5 99 6.16 0 2 863.97998 -2.43 25.26 1726.95952

VQYECATGYYTAGGK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 14 1 110611237 N-Term(iTRAQ4plex); C5(Methylthio); K15(iTRAQ4plex)

1.132 21 19.5 0.992 21 27.9 1.089 21 53.4 1.049 21 32.3 1.155 21 37.7 1.183 21 34.8 1.09 21 27.4 96 9.99 0 3 1087.9059 3.8 66.21 3261.7031

VREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWER

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

16 5 47132549;16933542

N-Term(iTRAQ4plex); C24(Methylthio)

1.941 8 50.2 0.982 8 31.7 1.594 8 50.6 1.242 8 41.7 2.177 8 36.6 2.034 8 54.4 1.2 8 11.1 95 8.52 0 3 1087.9059 3.8 66.21 3277.69516

VRGEESEVTVGGLEPGR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 2 1 188528648 N-Term(iTRAQ4plex) 1.445 9 8.8 1.016 9 16 1.241 9 12 1.25 9 17.2 1.569 9 25.5 1.486 9 28.2 1.166 9 14.3 93 5.89 0 3 1335.5886 2.93 36.7 2670.15799

VRPQQLVK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

2 2 31542984;262050538

N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.286 44 9.7 0.885 44 10.6 1.165 44 11 1.279 44 14 1.287 44 13.2 1.433 44 11.2 1.116 44 12.2 92 5.61 0 3 974.99384 8.71 29.21 1948.96086

VSALLTPAEQTGTWK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 40 1 105990532 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.261 31 13.2 0.927 31 14.9 1.164 31 14 1.251 31 10.1 1.278 31 14.7 1.419 31 12.6 1.144 31 9.5 90 6.69 0 3 685.05316 2.63 70.49 2053.14292

VSASPLLYTLIEK TFRC transferrin receptor protein 1 [Homo sapiens]

7037 NP_003225 2 1 189458817 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.494 6 25.5 1.018 6 17.7 1.449 6 19.8 1.367 6 22.6 1.571 6 30.1 1.581 6 15.5 1.194 6 12.5 89 8.33 0 3 1028.8452 3.1 69.34 3084.52365

VSATVSSPGSVPEVQDIQQNTDGSGQVSIPIIIPQTISELQLSVSAGSPHPAIAR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

7 6 178557739;67190748

N-Term(iTRAQ4plex) 1.12 50 10 0.949 50 12.6 1.006 50 15.3 1.063 50 13.3 1.117 50 17.9 1.226 50 13.7 1.107 50 11.2 89 6.45 0 3 1335.5886 2.93 36.7 2654.17655

VSDIRPGSDPTKPDATLVVK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 2 1 133925809 N-Term(iTRAQ4plex); K12(iTRAQ4plex); K20(iTRAQ4plex)

1.78 3 29.5 0.943 3 3.5 1.662 3 68.3 1.562 3 82.9 1.976 3 39.4 2.146 3 35.5 0.819 3 6.7 87 11.17 0 4 1014.5349 4.68 81.23 4055.11757

VSEADSSNADWVTK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 101 1 67782358 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.089 11 27.6 0.888 11 17 0.897 11 20.6 1.059 11 16.7 1.181 11 31.8 1.221 11 32.3 1.185 11 10.7 87 7.73 1 3 1388.2161 2.35 53.26 2775.42104

VSEPVSAGR ABI3BP target of Nesh-SH3 precursor [Homo sapiens]

25890 NP_056244 NP_079077

2 1 33667044 N-Term(iTRAQ4plex) 0.956 1 0.928 1 0.948 1 1.021 1 0.895 1 0.964 1 0.944 1 86 6.09 0 3 951.45514 1.67 68.72 2852.35086

VSFFCK APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 106 1 153266841 N-Term(iTRAQ4plex); C5(Methylthio); K6(iTRAQ4plex)

1.197 7 34 0.943 7 0.9 0.976 7 19.2 0.995 7 28.5 0.978 7 12.8 1.037 7 146.2 1.043 7 60.6 85 9.05 0 4 1014.5349 4.68 81.23 4039.10634

VSFLSALEEYTK APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 4 1 4557321 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.321 14 8.6 1.009 14 13.6 1.246 14 16.2 1.244 14 11.6 1.357 14 14.7 1.344 14 13 1.12 14 9.3 84 5.95 0 3 685.05316 2.63 70.49 2069.13645

VSHSEDDCLAFK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 10 1 115298678 N-Term(iTRAQ4plex); C8(Methylthio); K12(iTRAQ4plex)

1.157 78 7.8 0.969 78 9.3 1.073 78 11.8 1.113 78 10 1.206 78 10.7 1.25 78 9.6 1.122 78 6.3 80 4.85 0 3 854.4704 1.56 21.3 1707.92803

VSITSITVENVFVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 114 2 38016947 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.165 4 5.8 0.98 4 10.4 1.119 4 7.5 1.157 4 12.4 1.271 4 7.1 1.338 4 13.3 1.153 4 0.4 78 4.11 0 2 649.85797 2.75 16.01 1298.70867

VSLNILPPEEEEETHK TREML1 trem-like transcript 1 protein precursor [Homo sapiens]

340205 NP_835468 1 1 30794266 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.161 2 14 0.901 2 39.8 1.031 2 41.1 1.145 2 1.2 1.191 2 26.1 1.322 2 12.8 1.155 2 13.9 73 3.87 0 2 658.39734 3.79 16.98 1315.7874

VSMMQTK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 3 1 73858566 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.088 28 9.9 0.905 28 12.3 1.024 28 10.9 1.04 28 7.5 1.083 28 9.4 1.141 28 9.3 1.092 28 4.6 72 7.15 1 3 1060.6277 0.48 59.52 2120.24809

VSMMQTK SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 9 1 73858566 N-Term(iTRAQ4plex); M4(Oxidation); K7(iTRAQ4plex)

1.28 31 14.8 0.886 31 11.1 1.15 31 19.8 1.221 31 21.5 1.295 31 18.6 1.412 31 13.7 1.133 31 7.4 70 6.23 0 3 967.53595 1.51 46.48 1934.06462

VSNQTLSLFFTVLQDVPVR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 2 1 66932947 N-Term(iTRAQ4plex) 1.235 15 6.8 1.002 15 14.7 1.133 15 11.8 1.181 15 5.6 1.296 15 14.1 1.35 15 6.4 1.157 15 4 69 3.86 0 2 559.34528 1.17 12.13 1117.68254

VSPAAPER MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 1 1 71274107 N-Term(iTRAQ4plex) 1.152 24 7.3 0.99 24 12 1.073 24 7.1 1.077 24 8.2 1.224 24 8.3 1.241 24 10.5 1.159 24 6.4 67 4.69 0 2 657.31702 -0.7 36.21 1313.62541

VSQEGLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 9 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.045 4 3.1 0.896 4 7.3 0.938 4 1.8 1.046 4 5.6 1.059 4 2.1 1.165 4 9.4 1.115 4 1.6 65 5.41 0 3 616.68866 0.75 76.03 1848.05143

VSQYIEWLQK F7 coagulation factor VII isoform b precursor [Homo sapiens]

2155 NP_062562 8 2 10518503 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.255 22 10.3 0.997 22 15.3 1.188 22 15.7 1.213 22 11.7 1.271 22 22.4 1.367 22 21.9 1.122 22 19 64 7 0 4 804.1181 2.66 35.25 2410.32485

VSSFYAK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 3 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.214 11 8.6 0.915 11 8.6 1.105 11 8.4 1.201 11 9 1.221 11 9.7 1.334 11 3.5 1.153 11 5.2 64 5.9 0 3 691.8667 0.28 10.94 1382.72612

VSSQCADTR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C5(Methylthio)

1.318 52 12.5 0.915 52 26.6 1.189 51 16.4 1.287 51 21.5 1.333 52 22.4 1.488 52 17.9 1.131 51 17.1 62 9.12 0 3 1562.8076 1.8 69.99 3124.6146

VSSVEECQK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 1 1 78191798 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

1.214 123 10.2 0.937 123 14 1.109 123 15 1.179 123 12.1 1.246 123 12.5 1.318 123 11.7 1.122 123 12.6 56 7.26 0 3 843.78485 0.75 41.37 2529.34348

VSTAFVYTK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.181 14 8.9 0.998 14 15.6 1.109 14 15.5 1.111 14 2.4 1.263 14 15.6 1.299 14 3.2 1.157 14 3.2 56 3.1 0 2 510.80002 -0.05 6.26 1020.59374

VSTSPVGLPSIDPSGSSPSSSSAPLASFSGIPGTR

ANKHD1 ankyrin repeat and KH domain-containing protein 1 isoform 1 [Homo sapiens]

54882 NP_060217 1 2 46519147 N-Term(iTRAQ4plex) 1.377 8 10.2 1.048 8 12.5 1.312 8 15.2 1.373 8 6.5 1.462 8 20.6 1.55 8 5 1.118 8 2.4 55 3.19 0 2 649.85797 2.75 16.01 1314.70159

VSVFVDWIHK MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 4 1 205277383 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.267 6 4.8 0.948 6 17.6 1.2 6 7.4 1.227 6 13.9 1.323 6 14.5 1.333 6 14.6 1.136 6 5.6 55 3.41 0 2 575.33923 -0.52 15.09 1149.67119

VSVFVDWIHKVMR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 1 1 205277383 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.145 10 3.3 0.93 10 5.5 1.016 10 6.6 1.113 10 3.2 1.174 10 4.8 1.244 10 2.3 1.125 10 3.6 54 3.73 0 3 368.18585 2.88 10.4 1102.543

VSVGGEK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 12 1 67782358 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.015 5 17.9 1.004 5 16.2 0.911 5 20.6 1.01 5 11.6 1.122 5 30.8 1.118 5 11.4 1.136 5 12 50 5.38 1 3 877.51495 1.3 21.34 1754.01212

VSVHPDYR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

3 1 66347875 N-Term(iTRAQ4plex) 1.163 12 11.6 0.7 12 22.6 0.846 12 23.1 1.28 12 21.2 1.06 12 22.6 1.585 12 18.5 1.175 12 25.6 46 9.56 0 4 1324.658 0.94 43.22 3971.95932

VSVLCQENYLIQEGEEITCK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 404 1 62739186 N-Term(iTRAQ4plex); C5(Methylthio); C19(Methylthio); K20(iTRAQ4plex)

1.533 10 17.4 0.98 10 4.5 1.387 10 22.4 1.504 10 19.3 1.458 10 16.2 1.614 10 19.6 1.091 10 3.9 46 2.96 0 3 657.31702 -0.7 36.21 1329.62334

VSVNER HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 1 2 4826762 N-Term(iTRAQ4plex) 1.181 22 6.2 0.954 22 5.1 1.069 22 6.2 1.142 22 4.9 1.217 22 7 1.323 22 5.1 1.133 22 2.6 42 4.33 0 3 494.61307 0.9 40.01 1481.82465

Page 43: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

VSVQLEASPAFLAVPVEK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 12 1 66932947 N-Term(iTRAQ4plex); K18(iTRAQ4plex)

1.188 6 4 0.919 6 20.9 1.052 6 13.4 1.178 6 6.7 1.215 6 12.5 1.336 6 8 1.149 6 2.4 42 3.11 0 2 547.80847 -1.98 12.95 1094.61125

VSVSQTSK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 7 1 4503649 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.208 14 10.4 0.947 14 5.1 1.094 14 11.4 1.2 14 9.2 1.251 14 13.3 1.33 14 11 1.099 14 3.9 39 3.26 0 2 495.2912 0.31 39.56 989.57854

VSYVGLVTVR FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

3 1 154146262 N-Term(iTRAQ4plex) 1.724 1 0.984 1 1.627 1 1.654 1 1.793 1 1.822 1 1.102 1 38 0 2 649.85797 2.75 16.01 1330.69328

VTAAPQSVCALR A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 5 1 66932947 N-Term(iTRAQ4plex); C9(Methylthio)

1.193 8 5.3 0.959 8 14.4 1.106 8 7.9 1.143 8 4.3 1.27 8 7.7 1.307 8 9 1.148 8 3.2 37 3.2 0 2 518.29919 -0.39 13.12 1035.59355

VTAFLK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 1 1 4503625 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.166 1 0.96 1 1.129 1 1.176 1 1.156 1 1.204 1 1.024 1 36 3.63 1 3 426.57828 -0.14 9.77 1277.72028

VTASDPLDTLGSEGALSPGGVASLLR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

63 6 178557739;67190748

N-Term(iTRAQ4plex) 1.468 2 4.7 0.973 2 20 1.329 2 9.5 1.366 2 10.3 1.573 2 1.3 1.617 2 18.7 1.184 2 8.2 34 0 2 547.80847 -1.98 12.95 1110.60613

VTASSPVAVLSGHSCAQK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C15(Methylthio); K18(iTRAQ4plex)

1.124 1 0.847 1 0.994 1 1.174 1 1.082 1 1.278 1 1.088 1 5.22 0 4 440.00842 3.28 15.03 1757.01186

VTAWK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 1 1 156119625 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

0.96 4 10.7 0.892 4 3.6 0.865 4 15.4 0.97 4 13.5 0.959 4 9.6 1.113 4 12.9 1.086 4 5 84 6.46 0 3 563.28375 -0.59 24.93 1687.82553

VTCTNAELVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 17 2 38016947 N-Term(iTRAQ4plex); C3(Methylthio); K10(iTRAQ4plex)

0.977 3 7.1 0.918 3 28.7 1.021 3 38.5 0.961 3 1.5 0.989 3 39.6 1.303 3 12.5 1.356 3 14 78 8.44 0 3 1024.1476 4.08 53.82 3070.4282

VTDATETTITISWR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

103 5 47132549;16933542

N-Term(iTRAQ4plex) 1.215 1 0.824 1 0.934 1 1.134 1 1.281 1 1.555 1 1.371 1 78 5.85 0 3 563.28375 -0.59 24.93 1703.84433

VTEIWQEVMQR SOD3 extracellular superoxide dismutase [Cu-Zn] precursor [Homo sapiens]

6649 NP_003093 4 1 118582275 N-Term(iTRAQ4plex) 1.379 1 1.51 1 1.658 1 1.098 1 1.804 1 1.195 1 1.088 1 60 4.9 0 3 964.83008 1.05 58.36 2892.47568

VTEPISAESGEQVER APOL1 apolipoprotein L1 isoform c [Homo sapiens]

8542 NP_001130013 6 3 211938442 N-Term(iTRAQ4plex) 0.901 5 2.5 1.015 5 7.7 0.857 5 4.1 0.854 5 3.1 0.96 5 1.5 0.936 5 9.1 1.123 5 2.5 55 4.97 0 2 734.38788 -2.57 40.83 1467.76848

VTEPLDR CDH1 cadherin-1 preproprotein [Homo sapiens]

999 NP_004351 1 1 4757960 N-Term(iTRAQ4plex) 0.837 1 0.989 1 0.763 1 0.772 1 0.902 1 0.912 1 1.181 1 46 4.47 0 3 477.93375 -2.25 31.68 1431.78669

VTFELTYEELLK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 74 1 133925809 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.369 1 1.19 1 1.562 1 1.312 1 1.435 1 1.206 1 0.919 1 6.81 0 4 1024.1476 4.08 53.82 3086.42397

VTFHNK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 2 1 4557485 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.035 2 10.4 0.96 2 18.1 0.956 2 24.4 0.995 2 6.1 1.075 2 15 1.12 2 3 1.125 2 9.1 3.25 0 2 637.84326 -3.01 14.19 1274.67925

VTFHNKGAYPLSIEPIGVR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 1 1 4557485 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

3.76 2 4 1079.5391 -2.25 81.28 4315.13442

VTFQLTYEEVLK ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 178 2 156119625 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.634 1 0.896 1 1.47 1 1.64 1 1.629 1 1.817 1 1.108 1 120 6.02 0 2 1136.0931 -2.66 32.83 2271.179

VTGCPPFDEHK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 2 1 89191868 N-Term(iTRAQ4plex); C4(Methylthio); K11(iTRAQ4plex)

1.247 1 0.734 1 1.05 1 1.43 1 1.113 1 1.515 1 1.059 1 78 3.56 0 2 942.96881 0.48 55.89 1884.93035

VTGEGCVYLQTSLK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 16 1 66932947 N-Term(iTRAQ4plex); C6(Methylthio); K14(iTRAQ4plex)

1.704 4 1.6 0.974 4 13.4 1.587 4 16.4 1.658 4 4.9 1.805 4 7.8 1.997 4 13.5 1.183 4 4.9 75 5.76 0 2 990.50305 -3.69 61.54 1979.99883

VTGVVLFR SOD3 extracellular superoxide dismutase [Cu-Zn] precursor [Homo sapiens]

6649 NP_003093 3 1 118582275 N-Term(iTRAQ4plex) 1.629 1 0.808 1 1.356 1 1.678 1 1.589 1 1.967 1 1.172 1 74 4.63 0 2 1028.9982 -1.12 27.21 2056.98906

VTGWGNLK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 27 1 4503635 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.701 2 0.9 1.046 2 35.4 1.667 2 18.6 1.593 2 16.1 1.838 2 18.7 1.757 2 16 1.103 2 0.1 44 4.26 0 2 1031.9805 -3.33 46.48 2062.95366

VTHAVVTVPAYFNDAQR HSPA5 78 kDa glucose-regulated protein precursor [Homo sapiens]

3309 NP_005338 3 1 16507237 N-Term(iTRAQ4plex) 1.497 1 0.923 1 1.347 1 1.46 1 1.531 1 1.659 1 1.136 1 32 3.71 0 3 699.02869 -16.16 19.66 2095.07151

VTIDSSYDIAK CHI3L1 chitinase-3-like protein 1 precursor [Homo sapiens]

1116 NP_001267 1 1 144226251 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.016 1 0.842 1 1.742 1 2.069 1 1.972 1 2.343 1 1.132 1 78 7.49 0 3 895.07843 1.94 63.87 2683.22074

VTIGLLFWDGR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

50 2 31542984;262050538

N-Term(iTRAQ4plex) 1.453 1 1.038 1 1.459 1 1.405 1 1.503 1 1.448 1 1.03 1 70 3.92 0 2 711.86145 -1.5 18.57 1422.71562

VTIKPAPETEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 2 1 115298678 N-Term(iTRAQ4plex); K4(iTRAQ4plex); K11(iTRAQ4plex)

1.391 1 1.177 1 1.425 1 1.211 1 1.603 1 1.362 1 1.125 1 49 4.84 0 2 901.46838 -1.56 25.19 1801.92949

VTIMWTPPESAVTGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

22 5 47132549;16933542

N-Term(iTRAQ4plex) 1.463 1 0.724 1 1.151 1 1.589 1 1.371 1 1.893 1 1.191 1 46 4.65 0 2 913.92224 -7.66 31.38 1826.83721

VTIMWTPPESAVTGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

10 5 47132549;16933542

N-Term(iTRAQ4plex); M4(Oxidation)

1.101 1 1.331 1 1.252 1 0.941 1 1.315 1 0.987 1 1.05 1 42 3.34 0 2 584.82788 2.77 20.07 1168.64849

VTIPTDLIASSGDIIK DAG1 dystroglycan preproprotein [Homo sapiens]

1605 NP_001171114 2 1 294997306 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

2.351 1 0.955 1 2.071 1 2.167 1 2.526 1 2.644 1 1.22 1 42 3.73 0 2 658.76605 1.83 45.33 1316.52483

VTLTCVAPLSGVDFQLR A1BG alpha-1B-glycoprotein precursor [Homo sapiens]

1 NP_570602 118 1 21071030 N-Term(iTRAQ4plex); C5(Methylthio)

1.431 1 0.943 1 1.296 1 1.374 1 1.484 1 1.574 1 1.145 1 38 4.66 0 2 863.5293 -6.64 25.61 1726.05132

VTLTSEEEAR LDHA L-lactate dehydrogenase A chain isoform 2 [Homo sapiens]

3939 NP_001128711 2 3 207028494 N-Term(iTRAQ4plex) 0.678 1 1.063 1 0.706 1 0.664 1 0.694 1 0.653 1 0.984 1 33 5.07 0 3 984.86346 1.53 34.15 2952.57584

VTMLISGR LCN1 lipocalin-1 isoform 1 precursor [Homo sapiens]

3933 NP_002288 1 3 4504963 N-Term(iTRAQ4plex) 2.033 1 0.843 1 1.761 1 2.09 1 1.986 1 2.356 1 1.128 1 4.89 0 3 609.69208 0.41 34.63 1827.06168

VTMQNLNDR KRT16;KRT10;KRT14

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 10 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens]

3868;3858;3861

NP_005548;NP_000412 XP_352920;NP_000517

5 8 24430192;195972866;15431310

N-Term(iTRAQ4plex) 1.335 2 36.8 0.704 2 36.4 1.05 2 16.1 1.492 2 54.8 1.24 2 25.7 1.762 2 66.6 1.181 2 9.3 101 5.27 0 2 872.47156 0.01 34.58 1743.93584

VTMQNLNDR KRT16;KRT10;KRT14

keratin, type I cytoskeletal 16 [Homo sapiens];keratin, type I cytoskeletal 10 [Homo sapiens];keratin, type I cytoskeletal 14 [Homo sapiens]

3868;3858;3861

NP_005548;NP_000412 XP_352920;NP_000517

3 8 24430192;195972866;15431310

N-Term(iTRAQ4plex); M3(Oxidation)

1.163 1 1.015 1 1.136 1 1.118 1 1.209 1 1.191 1 1.065 1 81 5.44 0 2 868.90106 -0.48 21.16 1736.79485

VTNPK SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 12 1 50659080 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.056 2 18.1 1.041 2 13.2 1.031 2 28.2 0.99 2 14.6 1.127 2 22.1 1.082 2 8.8 1.093 2 5.8 76 4.72 0 2 844.48804 -0.47 63.01 1687.9688

VTPNLMGHLCGNQR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 10 3 221316614 N-Term(iTRAQ4plex); C10(Methylthio)

1.128 2 2.4 0.94 2 2.1 1.017 2 3.9 1.082 2 6 1.172 2 0.8 1.246 2 1.3 1.152 2 4.7 71 9.25 0 4 902.8316 -4.22 47.87 2706.49209

VTPNLMGHLCGNQR ECM1 extracellular matrix protein 1 isoform 1 precursor [Homo sapiens]

1893 NP_004416 2 3 221316614 N-Term(iTRAQ4plex); M6(Oxidation); C10(Methylthio)

1.243 2 19.7 1.042 2 22.6 1.156 2 21.7 1.109 2 0.8 1.386 2 40.2 1.33 2 16.5 1.199 2 17.4 69 5.63 0 3 736.41772 4.35 76.26 2207.23862

VTSIQDWVQK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 55 2 4826762 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.025 2 5.5 0.94 2 14.3 0.904 2 9.9 0.962 2 4.3 1.086 2 14.5 1.155 2 0.2 1.201 2 4.5 50 3.9 0 2 848.97345 -0.24 48.87 1696.93962

VTSKSESQVTMLQRQGFSMR

SLC7A2 low affinity cationic amino acid transporter 2 isoform 2 [Homo sapiens]

6542 NP_001008539 1 3 258614005 N-Term(iTRAQ4plex); K4(iTRAQ4plex)

0.978 2 1 0.937 2 10.9 0.888 2 9 0.948 2 1.9 1.007 2 0.1 1.074 2 10.7 1.133 2 8.8 45 3.52 0 2 690.32526 1.17 33.68 1379.64324

VTTSQDMLSIMEK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 46 1 73858568 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.075 2 11 0.878 2 12.6 0.962 2 17.5 1.096 2 4.8 1.058 2 16.6 1.206 2 3.9 1.1 2 0.9 44 3.53 0 2 602.81818 0.03 27.91 1204.62908

VTTSQDMLSIMEK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 12 1 73858568 N-Term(iTRAQ4plex); M11(Oxidation); K13(iTRAQ4plex)

1.116 2 7.6 1.022 2 14.9 1.052 2 15.8 1.03 2 0.8 1.207 2 14.6 1.181 2 0.3 1.147 2 1.1 38 0 2 571.81995 1.89 33.58 1142.63262

VTTSQDMLSIMEK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 4 1 73858568 N-Term(iTRAQ4plex); M7(Oxidation); M11(Oxidation); K13(iTRAQ4plex)

1.049 1 0.962 1 0.964 1 1.003 1 1.093 1 1.137 1 1.134 1 31 0 2 485.77609 1.09 20.76 970.54491

VTTTPK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.302 1 0.877 1 1.211 1 1.382 1 1.232 1 1.405 1 1.017 1 4.05 0 3 639.6618 5.58 26.21 1916.97086

VTTVASHTSDSDVPSGVTEVVVK

CLU clusterin preproprotein [Homo sapiens]

1191 NP_001822 30 1 355594753 N-Term(iTRAQ4plex); K23(iTRAQ4plex)

0.817 42 28.6 0.971 42 12.1 0.757 42 24 0.805 42 27.2 0.858 42 27 0.888 42 27.7 1.129 42 8 109 7.51 0 4 1036.5321 1.91 41.1 2072.05693

VTVFPIGIGDR VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex) 0.784 17 16.8 1.069 17 17.3 0.759 17 22.8 0.682 17 29.5 0.837 17 21.5 0.817 17 16.1 1.158 17 9.3 103 6.73 0 3 962.02557 0.65 47.32 1923.04387

VTVSCSGGMSLEGPSAFLCGSSLK

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 2 1 45580688 N-Term(iTRAQ4plex); C5(Methylthio); C19(Methylthio); K24(iTRAQ4plex)

0.71 39 15.1 0.826 39 9.2 0.617 39 17.2 0.762 39 22.6 0.689 39 21.5 0.821 39 16.5 1.068 39 8.7 96 6.87 0 3 1047.568 3.07 26.99 2094.11789

VTVSCSGGMSLEGPSAFLCGSSLK

C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 2 1 45580688 N-Term(iTRAQ4plex); C5(Methylthio); M9(Oxidation); C19(Methylthio); K24(iTRAQ4plex)

0.762 21 15.5 1.046 21 20.7 0.724 21 28.9 0.706 21 16.2 0.84 21 17.9 0.83 21 15.6 1.16 21 8.7 87 6.31 0 2 848.45825 -3.77 24.95 1695.91875

VTVTNPDTGR CNTN1 contactin-1 isoform 2 precursor [Homo sapiens]

1272 NP_778203 1 2 28373119 N-Term(iTRAQ4plex) 0.656 7 22 0.986 7 31 0.546 7 27.4 0.673 7 2 0.689 7 11.8 0.756 7 5.9 1.166 7 7.1 83 4.18 0 3 742.8844 -0.59 18.13 1484.74363

VTWAPPPSIDLTNFLVR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

24 5 47132549;16933542

N-Term(iTRAQ4plex) 0.746 8 18.1 0.875 8 20 0.66 8 15.4 0.796 8 22.9 0.694 8 12.4 0.853 8 12.6 1.081 8 5.8 81 6.46 0 4 1141.5992 -2.97 19.38 2282.1813

VTYDVSR ITIH1 inter-alpha-trypsin inhibitor heavy chain H1 isoform a precursor [Homo sapiens]

3697 NP_002206 2 2 156119625 N-Term(iTRAQ4plex) 0.813 32 8.5 1.078 32 9.2 0.803 32 17.4 0.755 32 12.1 0.907 32 12 0.849 32 13.1 1.138 32 4.9 77 3.67 0 3 686.36792 -8.24 24.1 1371.73064

VTYTSQEDLVEK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 12 1 119392081 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.623 13 16.7 0.966 13 27 0.552 13 29.7 0.639 13 7.1 0.646 13 15.3 0.73 13 13.1 1.158 13 5.6 76 3.96 0 2 682.87708 1.16 39.4 1364.74687

VVAEGFDFANGINISPDGK PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 6 1 19923106 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

0.699 20 7.1 0.976 20 6.1 0.631 20 9.8 0.676 20 12 0.729 20 10.9 0.763 20 8.1 1.163 20 6.6 73 5.91 0 3 485.93939 -2.79 30.74 1455.81516

VVAEVQICHGK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C8(Methylthio); K11(iTRAQ4plex)

1.157 11 7.3 0.93 11 8 1.048 11 9.4 1.131 11 6.3 1.181 11 10.5 1.326 11 5.9 1.129 11 4.1 69 4.77 0 3 468.92471 2.29 24.04 1404.75959

VVAGEVQVQR IGSF8 immunoglobulin superfamily member 8 precursor [Homo sapiens]

93185 NP_001193594 1 1 331284207 N-Term(iTRAQ4plex) 0.502 5 16.3 0.997 5 8.5 0.446 5 1.1 0.452 5 7 0.54 5 15.4 0.559 5 22.5 1.144 5 8.4 67 6.11 0 3 923.99805 -10.83 25.44 1847.01596

VVAQGVGIPEDSIFTMADR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 9 1 4502067 N-Term(iTRAQ4plex) 0.741 1 1.041 1 0.699 1 0.672 1 0.814 1 0.782 1 1.164 1 64 4.25 2 2 1009.6012 4.6 33.6 2018.19512

VVAQGVGIPEDSIFTMADR AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 8 1 4502067 N-Term(iTRAQ4plex); M16(Oxidation)

0.734 16 27.5 1.11 16 14.3 0.725 16 29.4 0.66 16 27.5 0.831 16 34.2 0.793 16 25.6 1.164 16 6.3 64 4.86 0 2 688.39014 4.24 20.4 1375.773

VVAQSTNSEEIIEGEYNTVMLAIGR

TXNRD1 thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]

7296 NP_877419 1 3 33519428 N-Term(iTRAQ4plex); M20(Oxidation)

1.124 3 1.3 0.971 3 2.6 0.991 3 12.2 1.027 3 1.6 1.207 3 5.1 1.175 3 3.1 1.218 3 0.7 63 6.71 0 3 923.99805 -10.83 25.44 1863.00748

VVATTQMQAADAR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 4 1 157266300 N-Term(iTRAQ4plex) 0.461 9 21.2 1.002 9 8.7 0.448 9 31.1 0.418 9 33.5 0.525 9 24.2 0.495 9 14.1 1.172 9 10.4 58 4.41 0 3 453.92236 -0.74 24.37 1359.7542

VVATTQMQAADAR ANPEP aminopeptidase N precursor [Homo sapiens]

290 NP_001141 1 1 157266300 N-Term(iTRAQ4plex); M7(Oxidation)

0.642 3 11.4 1.128 3 3.5 0.612 3 0.1 0.576 3 12.5 0.669 3 9.9 0.634 3 28.7 1.094 3 0.8 55 5.55 1 2 876.48212 -7.03 30.51 1751.95085

VVCSCTEGYR F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 8 1 4503649 N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio)

0.635 4 19.8 0.901 4 13.8 0.569 4 35.2 0.69 4 21.2 0.638 4 27.8 0.764 4 12.3 1.153 4 2.8 54 4.37 0 2 819.93018 -2.86 16.87 1638.85307

VVDKIDVCPENAEVTLTDFR COMP cartilage oligomeric matrix protein precursor [Homo sapiens]

1311 NP_000086 2 1 40217843 N-Term(iTRAQ4plex); K4(iTRAQ4plex); C8(Methylthio)

0.746 1 0.942 1 0.697 1 0.74 1 0.751 1 0.798 1 1.078 1 52 5.8 0 3 508.63568 9.22 16.09 1523.89249

VVDPTKP SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 2 1 21361302 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.7 4 6.8 1.001 4 6.5 0.662 4 11.4 0.648 4 3.8 0.762 4 10.3 0.767 4 3.8 1.142 4 3.7 51 3.64 0 2 560.30872 -2.24 17.55 1119.61308

VVEEQESR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

43 4 178557739;67190748

N-Term(iTRAQ4plex) 0.75 3 2.6 1.024 3 6 0.708 3 6.9 0.687 3 5.5 0.844 3 10.6 0.799 3 1.9 1.164 3 3.6 50 4.05 0 2 621.35956 2.1 11.77 1241.71184

VVEESELAR C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 12 1 4502511 N-Term(iTRAQ4plex) 0.736 9 8.1 0.986 9 4.8 0.713 9 7.1 0.759 9 6.7 0.756 9 8.6 0.798 9 9.4 1.071 9 2.2 49 3.54 0 2 624.83948 0.94 21.1 1248.66582

VVFLNTQLCQFRPDAFGGLPR

CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

156 1 256217721 N-Term(iTRAQ4plex); C9(Methylthio)

1.212 11 3.6 0.918 11 15.2 1.111 11 7.2 1.209 11 11.3 1.277 11 5.4 1.376 11 7.6 1.138 11 4.2 46 4.43 0 3 453.92236 -0.74 24.37 1375.74781

VVGGCVAHPHSWPWQVSLR

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 29 1 4505881 N-Term(iTRAQ4plex); C5(Methylthio)

0.843 8 23.5 0.907 8 24 0.725 8 22.5 0.846 8 11.7 0.825 8 27.7 0.96 8 11.6 1.133 8 3.8 45 3.84 0 2 567.82532 6.72 10.97 1134.63591

VVGGHPGNSPWTVSLR MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 6 1 205277383 N-Term(iTRAQ4plex) 0.727 10 9.6 1.014 10 12.9 0.713 10 19.9 0.696 10 10.8 0.803 10 12.1 0.815 10 13.7 1.161 10 7.3 44 3.76 0 2 623.83899 -4.25 20.38 1246.67351

VVGGLVALR F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 10 1 145275213 N-Term(iTRAQ4plex) 0.181 2 224 0.748 1 0.062 2 96.8 0.143 1 0.158 2 987.5 0.898 1 2.556 2 220.3 43 0 3 1227.9457 5.14 54.84 3681.82248

VVGLIQDLKPNTIMVLVNYIHFK

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 10 1 205277441 N-Term(iTRAQ4plex); K9(iTRAQ4plex); M14(Oxidation); K23(iTRAQ4plex)

0.595 3 14.2 0.878 3 6.7 0.537 3 23.8 0.612 3 10.3 0.581 3 13.7 0.662 3 1.6 1.083 3 8.7 43 5.4 1 4 557.78906 -8.83 31.48 2228.13242

VVGLIQDLKPNTIMVLVNYIHFK

SERPINA7 thyroxine-binding globulin precursor [Homo sapiens]

6906 NP_000345 14 1 205277441 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K23(iTRAQ4plex)

0.752 4 5.7 0.985 4 11.5 0.737 4 17.4 0.72 4 9 0.823 4 18.6 0.803 4 12.1 1.15 4 2.1 38 3.59 0 2 564.32867 -3.61 33.17 1127.65483

VVHAAK AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 8 1 156523970 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.689 1 0.686 1 0.535 1 0.78 1 0.626 1 0.913 1 1.169 1 34 0 2 496.28543 -2.69 10.85 991.56359

VVHFIYIAILSQKFPK AFM afamin precursor [Homo sapiens] 173 NP_001124 2 1 4501987 N-Term(iTRAQ4plex); K13(iTRAQ4plex); K16(iTRAQ4plex)

3.691 2 671.3 0.781 2 28.5 4.581 2 1584.5 5.866 2 3181 0.611 2 79.1 0.783 2 43.7 0.133 2 10420.4 33 0 4 1227.9457 5.14 54.84 3697.81455

VVIVERK SPAG17 sperm-associated antigen 17 [Homo sapiens]

200162 NP_996879 1 1 46240864 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.89 2 16 0.978 2 5.8 0.896 2 29.9 0.916 2 23.8 0.861 2 7.8 0.88 2 2 0.961 2 21.7 5.29 1 3 547.6272 2.15 16.45 1640.86704

VVLGDQDLK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 14 2 295054188 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

0.61 1 0.988 1 0.573 1 0.58 1 0.639 1 0.647 1 1.116 1 3.74 1 3 468.26498 2.34 18.8 1402.7804

VVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPR

MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 1 1 21264359 N-Term(iTRAQ4plex); C35(Methylthio)

0.654 1 0.963 1 0.617 1 0.641 1 0.666 1 0.692 1 1.08 1 2.93 0 2 560.81787 4.75 24.7 1120.62847

VVLHPNYSQVDIGLIK HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 16 2 4826762 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

0.596 1 1.188 1 0.571 1 0.48 1 0.732 1 0.617 1 1.284 1 42 2.87 0 2 580.85858 -2.62 19.13 1160.70989

VVLLPSCPGAPGSPGEK FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 2 2 27754776 N-Term(iTRAQ4plex); C7(Methylthio); K17(iTRAQ4plex)

0.958 1 0.911 1 0.859 1 0.943 1 0.971 1 1.066 1 1.13 1 35 1 3 584.00317 -0.53 19.57 1749.99497

VVLSFDFPFYGHPLR PLXDC1 plexin domain-containing protein 1 precursor [Homo sapiens]

57125 NP_065138 1 1 15011862 N-Term(iTRAQ4plex) 1.56 1 0.88 1 1.361 1 1.547 1 1.571 1 1.785 1 1.154 1 32 0 2 440.27234 -1.78 10.15 879.5374

VVLSQGSK SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 5 2 7382460 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.288 1 1.095 1 1.191 1 1.088 1 1.507 1 1.376 1 1.265 1 39 6.85 0 3 950.4455 -0.08 51.64 2849.32193

VVLSSGSGPGLDLPLVLGLPLQLK

SHBG sex hormone-binding globulin isoform 1 precursor [Homo sapiens]

6462 NP_001031 16 2 7382460 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

2.574 2 1.4 0.946 2 18.3 2.38 2 9.8 2.515 2 8.4 2.638 2 5.3 2.787 2 12.9 1.108 2 4.5 2.81 0 2 687.92291 -4.47 42.83 1374.83855

VVLVAVDK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 21 1 115298678 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

2.599 8 30.1 0.877 8 22.8 2.039 8 31.6 2.449 8 27.6 2.454 8 44.8 2.96 8 46 1.135 8 15.5 122 7.8 0 3 1330.82 4.53 68.77 2660.61747

VVLVSLQSGYLFIQTDK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 8 1 115298678 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

2.058 2 4.9 0.945 2 2 1.772 2 10.9 1.876 2 8.9 2.227 2 1.9 2.357 2 0.1 1.257 2 9 97 11.44 0 3 1086.2529 3.82 38.17 3256.74424

VVMYEGK THBS1 thrombospondin-1 precursor [Homo sapiens]

7057 NP_003237 1 1 40317626 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.015 1 1.075 1 1.858 1 1.728 1 2.323 1 2.16 1 1.25 1 94 6.75 0 3 986.48877 3.72 66.92 2957.45176

VVNNSPQPQNVVFDVQIPK ITIH2 inter-alpha-trypsin inhibitor heavy chain H2 precursor [Homo sapiens]

3698 NP_002207 40 1 70778918 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.31 4 41.7 0.878 4 6.1 1.15 4 39.6 1.367 4 45.7 1.262 4 37.4 1.501 4 44.5 1.112 4 1.2 80 6.06 0 2 1341.1459 0.88 47.73 2681.28447

VVNPTQK SERPINA1 alpha-1-antitrypsin precursor [Homo sapiens]

5265 NP_001121177 4 1 189163538 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.222 4 23.4 1.246 2 26.9 1.976 4 21.6 1.586 2 27.3 2.212 4 6.5 1.855 2 30.4 1.104 4 8.7 79 5.94 0 3 1298.6752 -7.07 23.59 2596.3425

VVPDCNNYR PEBP4 phosphatidylethanolamine-binding protein 4 precursor [Homo sapiens]

157310 NP_659399 1 1 116812622 N-Term(iTRAQ4plex); C5(Methylthio)

2.101 3 0.9 0.833 3 1 1.827 3 2.8 2.194 3 1.8 2.025 3 0.1 2.447 3 1 1.129 3 2.7 74 8.69 0 3 808.10693 2.17 50.88 2422.30625

VVPEGVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 4 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.572 6 11.2 0.862 6 17.5 2.157 6 14.1 2.545 6 6.5 2.56 6 10.2 2.975 6 9.4 1.197 6 6.6 72 4.59 0 2 737.89929 -4.7 18.75 1474.79521

VVSLSPEDAPGPSLR GPR149 probable G-protein coupled receptor 149 [Homo sapiens]

344758 NP_001033794 XP_293580 XP_946285

1 1 84662753 N-Term(iTRAQ4plex) 2.303 23 10.9 0.92 23 19.5 2.065 23 13.8 2.158 23 22.4 2.361 23 21.1 2.528 23 14.1 1.204 23 12.2 66 7.52 0 3 866.53754 3.15 73.03 2597.59806

VVSMDENFHPLNELIPLVYIQDPK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 42 1 66932947 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

2.392 3 16.1 0.882 3 13.1 2.019 3 13.5 2.499 3 14.5 2.305 3 7.1 2.848 3 0.3 1.142 3 6.4 63 5.29 0 2 793.48193 1.19 63.96 1585.95806

VVSMDENFHPLNELIPLVYIQDPK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 3 1 66932947 N-Term(iTRAQ4plex); M4(Oxidation); K24(iTRAQ4plex)

2.15 6 11.3 1.068 6 4.2 1.969 6 18.8 1.843 6 11 2.41 6 16.2 2.208 6 11.7 1.124 6 14.2 57 4.94 0 3 709.69391 1.61 40.32 2127.05692

VVSVDENFRPR PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex) 2.549 3 6.3 0.969 3 17.3 1.954 3 46.7 2.429 3 17.2 2.422 3 27.8 2.674 3 35.8 1.125 3 3.2 53 3.09 0 2 553.34454 -0.13 13.73 1105.68205

VVSVHPGDVLITSCTYNTEDR

DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 6 1 116534900 N-Term(iTRAQ4plex); C14(Methylthio)

3.212 1 0.907 1 2.846 1 3.137 1 3.28 1 3.615 1 1.152 1 48 0 2 656.82758 0.14 54.24 1312.64787

VVTEADVYITFGIR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 34 2 38016947 N-Term(iTRAQ4plex) 2.456 9 12.3 0.957 9 9.2 2.22 9 22.1 2.398 9 14 2.409 9 10.5 2.691 9 6.6 1.145 9 3.5 48 4.16 0 3 728.91101 0.71 66.06 1456.82024

VVTFCDYAYNTFQVTTGGMVLK

C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 30 1 87298828 N-Term(iTRAQ4plex); C5(Methylthio); K22(iTRAQ4plex)

2.753 1 1.006 1 2.608 1 2.592 1 2.915 1 2.897 1 1.118 1 46 3.35 0 2 602.86005 -0.97 14.79 1204.71282

VVTFCDYAYNTFQVTTGGMVLK

C1QB complement C1q subcomponent subunit B precursor [Homo sapiens]

713 NP_000482 2 1 87298828 N-Term(iTRAQ4plex); C5(Methylthio); M19(Oxidation); K22(iTRAQ4plex)

2.573 3 3.4 0.931 3 9.6 2.363 3 4.9 2.457 3 4.7 2.688 3 1.9 2.705 3 2.4 1.123 3 3 39 3.75 0 2 656.82758 0.14 54.24 1296.65325

VVTPLSPPTNLHLEANPDTGVLTVSWER

FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

49 5 47132549;16933542

N-Term(iTRAQ4plex) 2.566 2 4.7 0.991 2 5.4 2.408 2 3.1 2.431 2 8.6 2.702 2 1 2.727 2 6.4 1.122 2 2.1 35 3.3 0 2 528.77991 7.86 23.17 1056.55254

VVTVLVR DBH dopamine beta-hydroxylase precursor [Homo sapiens]

1621 NP_000778 1 1 116534900 N-Term(iTRAQ4plex) 1.686 1 0.948 1 1.602 1 1.69 1 1.683 1 1.776 1 1.051 1 2.84 0 2 594.32745 -2.09 32.38 1187.64763

VVVCQEHSCKPGQVCQPSGGILSCVTK

FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

1 1 154146262 N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio); K10(iTRAQ4plex); C15(Methylthio); C24(Methylthio); K27(iTRAQ4plex)

1.248 24 7.2 0.932 24 16.7 1.131 24 11.9 1.237 24 15.1 1.311 24 11.3 1.379 24 9 1.182 24 9.3 122 7.99 0 3 1281.5978 1.65 47.76 2562.17997

VVVHPDYR C1RL complement C1r subcomponent-like protein precursor [Homo sapiens]

51279 NP_057630 1 1 289547636 N-Term(iTRAQ4plex) 1.935 8 20.7 0.917 8 12.5 1.735 8 24.9 1.969 8 29.2 1.962 8 15.3 2.158 8 16.1 1.101 8 6.8 113 7.59 0 3 1281.5978 1.65 47.76 2578.1832

VVVQTESGGR PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 2 1 162809334 N-Term(iTRAQ4plex) 1.388 66 11.1 0.969 66 17 1.327 66 12.4 1.297 66 10.9 1.463 66 14.9 1.463 66 9.2 1.127 66 10.5 110 6.92 0 2 946.01477 0.97 66.57 1891.01749

VWFAMKTFLTPSIFIIMVWYWR

WLS protein wntless homolog isoform 3 [Homo sapiens]

79971 NP_001180263 1 3 300934787 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

3.022 8 46.6 0.787 8 24 2.539 7 61 3.084 8 12.1 2.979 7 26.2 3.928 8 33.4 1.143 8 14.7 108 8.88 0 4 947.8147 1.49 80.01 2841.42959

VWLEVEPVGMLK MCAM cell surface glycoprotein MUC18 precursor [Homo sapiens]

4162 NP_006491 4 1 71274107 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.37 3 6 0.882 3 11.8 1.274 3 12.3 1.387 3 6.1 1.41 3 22.7 1.358 3 24.6 1.107 3 10.2 107 10.49 0 3 1133.3146 4.29 47.97 3397.92917

VWPQQPSGELFEIEIDTLETTCHVLDPTPVAR

AHSG alpha-2-HS-glycoprotein preproprotein [Homo sapiens]

197 NP_001613 85 1 156523970 N-Term(iTRAQ4plex); C22(Methylthio)

1.892 17 19.7 0.908 17 18.7 1.744 17 27 1.811 17 21.9 1.891 16 23.5 2.017 17 29 1.118 17 17 106 9.79 0 3 947.8147 1.49 80.01 2825.42429

Page 44: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

VWVQAFK LAMP1 lysosome-associated membrane glycoprotein 1 precursor [Homo sapiens]

3916 NP_005552 4 1 112380628 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.499 17 9.3 0.957 17 19.8 1.338 17 14.9 1.357 17 11.4 1.559 17 7 1.634 17 21.8 1.169 17 10.9 104 5.59 0 3 1027.0635 -0.58 55.51 2053.11968

VWVYPPEK HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 507 1 11321561 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.919 15 11.5 0.908 15 10.1 0.814 15 22.6 0.878 15 15.3 0.966 15 20.1 0.94 15 19.4 1.117 15 25.2 102 9.54 0 3 947.8147 1.49 80.01 2809.44101

VYALPEDLVEVNPK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 4 1 167614506 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.381 35 7 0.978 35 12.5 1.24 35 9.7 1.308 35 9.6 1.413 35 12.9 1.474 35 11.4 1.139 35 6 86 5.89 0 2 930.97766 0.57 27.3 1860.9384

VYAYYNLEESCTR C3 complement C3 precursor [Homo sapiens]

718 NP_000055 58 1 115298678 N-Term(iTRAQ4plex); C11(Methylthio)

1.282 4 3.9 0.928 4 1.3 1.188 4 3.7 1.275 4 3.3 1.307 4 9.9 1.405 4 9 1.102 4 11.6 85 7.43 0 3 1219.6561 9.44 28.63 2438.30472

VYDYYETDEFAIAEYNAPCSK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 4 1 66932947 N-Term(iTRAQ4plex); C19(Methylthio); K21(iTRAQ4plex)

1.173 6 8.1 0.919 6 15.6 1.048 6 21.1 1.246 6 12.9 1.152 6 10.9 1.345 6 11.9 1.136 6 6.3 76 4.87 0 2 812.41583 -0.25 47.87 1623.82305

VYFAGFPR PROS1 vitamin K-dependent protein S preproprotein [Homo sapiens]

5627 NP_000304 2 1 192447438 N-Term(iTRAQ4plex) 1.281 2 60.1 0.523 2 100.4 1.461 2 108.1 2.792 2 4.5 0.559 2 87.8 1.067 2 7.9 0.382 2 12.4 68 9.61 1 4 775.16174 -0.73 74.3 3097.62514

VYLIYGNDLGLPPVDLDLDK GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 8 1 29171717 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.258 11 8.9 0.892 11 18.9 1.137 11 14.2 1.275 11 6.9 1.238 11 10.8 1.354 11 6 1.072 11 6.6 63 4.45 0 3 407.2363 -0.51 47.64 1219.69434

VYLIYGNDLGLPPVDLDLDKEAHR

GPLD1 phosphatidylinositol-glycan-specific phospholipase D isoform 1 precursor [Homo sapiens]

2822 NP_001494 5 1 29171717 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.672 3 14.5 0.499 3 111.9 1.466 3 1.5 2.97 3 23 1.737 3 91.3 4.073 3 80.8 1.185 3 1 61 10.16 1 4 775.16174 -0.73 74.3 3113.62807

VYLSECK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 20 2 4505881 N-Term(iTRAQ4plex); C6(Methylthio); K7(iTRAQ4plex)

0.926 2 37.7 1.05 2 17.3 0.899 2 26.3 0.856 2 45.1 1.002 2 30 0.954 2 49.1 1.114 2 3.5 57 2.97 0 2 576.87183 1.78 14.42 1152.73638

VYPGEQYTYMLLATEEQSPGEGDGNCVTR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 12 1 4557485 N-Term(iTRAQ4plex); M10(Oxidation); C26(Methylthio)

1.325 1 0.985 1 1.278 1 1.298 1 1.352 1 1.373 1 1.058 1 50 3.27 0 2 407.2363 -0.51 47.64 1235.68547

VYPGEQYTYMLLATEEQSPGEGDGNCVTR

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 37 1 4557485 N-Term(iTRAQ4plex); C26(Methylthio)

1.43 2 3.2 0.947 2 17.7 1.288 2 6 1.361 2 11.6 1.5 2 4.8 1.585 2 12.9 1.165 2 1.2 37 3.9 0 2 602.85687 -6.24 15.5 1204.70647

VYSLNDDLKPAK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 4 2 38016947 N-Term(iTRAQ4plex); K9(iTRAQ4plex); K12(iTRAQ4plex)

1.371 1 0.986 1 1.3 1 1.319 1 1.422 1 1.442 1 1.094 1 2.86 0 2 570.33325 -6.19 14.89 1139.65923

VYVHLK CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 1 1 4557485 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.204 65 50.8 1.057 60 35.9 1.107 64 42.7 1.097 59 56.2 1.232 64 41.6 1.337 59 37.7 1.127 63 30.7 137 9.22 0 3 1116.5697 -2.32 40.11 3347.70224

WADLSGITK SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 23 1 21361302 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

2.025 30 30.1 0.965 29 49.5 1.974 31 65.5 2.102 29 43.2 1.977 30 49.6 2.036 28 35.9 1.09 30 37.8 115 9.36 0 3 1116.5697 -2.32 40.11 3363.68772

WANQCNYR CRISP3 cysteine-rich secretory protein 3 isoform 1 precursor [Homo sapiens]

10321 NP_006052 2 2 300244560 N-Term(iTRAQ4plex); C5(Methylthio)

1.738 1 0.781 1 1.733 1 2.218 1 1.363 1 1.744 1 0.786 1 98 5.22 0 3 931.78979 -0.95 66.25 2793.35483

WCGTTQNYDADQK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

23 6 47132549;16933542

N-Term(iTRAQ4plex); C2(Methylthio); K13(iTRAQ4plex)

1.67 2 19.6 1.376 2 26.5 1.945 2 3.7 1.414 2 30.5 2.037 2 4.9 1.481 2 31.8 1.048 2 1.2 95 7.28 0 3 1080.9076 -5.24 81.71 3240.73056

WDEELAAFAK PI16 peptidase inhibitor 16 precursor [Homo sapiens]

221476 NP_699201 10 1 70780384 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.457 4 16 0.94 4 9.8 1.365 4 1.9 1.47 4 11.8 1.437 4 15.6 1.559 4 28.6 1.1 4 12 90 6.97 0 3 1514.2033 5.22 41.52 3027.39017

WDFDNRPHILHGEYIEFICR F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 3 1 110611237 N-Term(iTRAQ4plex); C19(Methylthio)

1.401 11 18.2 0.902 11 22.8 1.141 11 15.6 1.407 11 22.4 1.579 11 54.6 1.754 11 28.3 1.172 11 22.1 89 7.68 0 3 1080.9076 -5.24 81.71 3256.72776

WEAEPVYVQR AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 17 1 4502337 N-Term(iTRAQ4plex) 1.525 68 10.3 0.929 68 14.2 1.386 68 13.8 1.441 68 11.5 1.607 68 17.9 1.718 68 13.8 1.178 68 13.5 88 7.53 0 3 867.43146 -0.06 56.63 2600.28293

WEDILSDEVNVAR CRTAC1 cartilage acidic protein 1 isoform B precursor [Homo sapiens]

55118 NP_001193457 4 2 330688397 N-Term(iTRAQ4plex) 1.176 9 6.9 0.865 9 15.1 1.078 9 14 1.224 9 16.1 1.168 9 10.3 1.383 9 6.3 1.126 9 9 80 5.79 0 3 931.78979 -0.95 66.25 2777.36386

WELALGR APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 1 1 4557325 N-Term(iTRAQ4plex) 1.425 10 12.3 1.066 10 20.8 1.482 10 13.8 1.37 10 16.6 1.672 10 11.9 1.532 10 16.4 1.166 10 17.9 80 6.29 0 3 754.37091 -2.46 17.53 2261.08756

WELCDIPR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 34 1 4505881 N-Term(iTRAQ4plex); C4(Methylthio)

1.537 48 7.9 0.901 48 13 1.379 48 16.5 1.524 48 9.5 1.553 48 11.6 1.68 48 11.4 1.11 48 9.9 74 5.43 0 3 517.62036 1.13 35.86 1550.84763

WELDLDIK PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 8 1 4506115 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.484 30 9.5 0.971 30 12.9 1.373 30 11.3 1.416 30 8.3 1.566 30 12.3 1.587 30 7.9 1.131 30 3.1 71 4.35 0 2 684.3927 0.6 84.88 1367.77812

WELLQQMNVGTRPINLEPIFQGYIDSLK

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); M7(Oxidation); K28(iTRAQ4plex)

1.514 47 8.9 0.987 47 11.3 1.408 47 14 1.439 47 9.5 1.591 47 12.8 1.667 47 10.1 1.131 47 3.6 63 4.03 0 3 704.9245 -1.82 59.82 1408.84441

WELLQQMNVGTRPINLEPIFQGYIDSLKR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); M7(Oxidation); K28(iTRAQ4plex)

1.533 12 12.5 1.034 12 19.5 1.471 12 18 1.42 12 14.7 1.615 12 16.8 1.58 12 8.3 1.1 12 2.4 61 4.41 0 2 684.39691 6.75 17.54 1367.77129

WELLQQMNVGTRPINLEPIFQGYIDSLKR

KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 2 2 47132620 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

1.481 25 10.5 0.873 25 12.8 1.272 25 12.9 1.47 25 12.4 1.504 25 7.5 1.657 25 14.9 1.156 25 11.4 60 7.57 0 3 699.71893 0.94 51.11 2097.14225

WELLQQVDTSTR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 8 2 119395750 N-Term(iTRAQ4plex) 1.347 2 7.1 1.051 2 34.9 1.694 2 22.8 1.611 2 11.4 1.087 2 28.1 1.034 2 6.3 0.642 2 5.1 58 6.83 1 3 1116.9224 2.51 80.18 3348.75254

WEMPFDPQDTHQSR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 129 1 50659080 N-Term(iTRAQ4plex) 1.555 66 6.6 0.991 66 9.2 1.454 66 10.8 1.496 66 9.2 1.638 66 10.2 1.702 66 9.5 1.139 66 3.6 56 3.06 0 2 554.35291 -2.8 37.97 1107.70049

WEMPFDPQDTHQSR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 30 1 50659080 N-Term(iTRAQ4plex); M3(Oxidation)

1.436 6 12.6 1.013 6 11.8 1.314 6 20.7 1.349 6 7.1 1.509 6 17.9 1.522 6 4.2 1.121 6 4.8 54 3.53 0 2 594.3396 -13.07 17.61 1187.69328

WENLECVQK LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 2 2 341915493 N-Term(iTRAQ4plex); C6(Methylthio); K9(iTRAQ4plex)

1.211 7 3.5 0.984 7 10 1.163 7 4.7 1.206 7 5.2 1.256 7 6.7 1.253 7 7.3 1.066 7 4 52 4.51 0 2 653.81848 0.47 22.62 1306.62969

WEPPAGTAEDQVLGYR PTPRS receptor-type tyrosine-protein phosphatase S isoform 2 precursor [Homo sapiens]

5802 NP_570924 1 2 104487297 N-Term(iTRAQ4plex) 1.597 11 8.2 0.91 11 15.2 1.499 11 24.1 1.596 11 6.9 1.714 11 19.5 1.933 11 16.3 1.136 11 4.9 50 3.8 0 3 391.56287 -1.32 19.77 1172.67729

WEYCNLK PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 63 1 4505881 N-Term(iTRAQ4plex); C4(Methylthio); K7(iTRAQ4plex)

1.79 2 22.5 1.064 2 18.6 1.823 2 18.9 1.713 2 0.2 1.866 2 46.8 1.753 2 26.4 1.024 2 26.2 48 0 3 653.81848 0.47 22.62 1322.62314

WEYYDSVYTER DPP4 dipeptidyl peptidase 4 [Homo sapiens]

1803 NP_001926 2 1 18765694 N-Term(iTRAQ4plex) 1.439 1 0.943 1 0.919 1 0.974 1 1.877 1 1.991 1 2.043 1 47 5.46 1 4 932.02484 0.75 80.59 3725.07754

WFLLEQPEIQVAHFPFK SERPINF2 alpha-2-antiplasmin isoform a precursor [Homo sapiens]

5345 NP_000925 157 2 115583663 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.382 1 1.081 1 1.361 1 1.259 1 1.516 1 1.402 1 1.113 1 44 0 2 537.34814 -2.9 24.72 1073.68901

WFLQHRPQVGYIR THBS4;COMP

thrombospondin-4 precursor [Homo sapiens];cartilage oligomeric matrix protein precursor [Homo sapiens]

7060;1311 NP_003239;NP_000086

2 2 31543806;40217843

N-Term(iTRAQ4plex) 1.535 2 6.8 0.976 2 1.9 1.42 2 10.3 1.455 2 8.4 1.614 2 5.5 1.653 2 3.6 1.136 2 4.8 44 2.83 0 2 489.78339 -1.65 16.04 978.5595

WFTCVLK F11 coagulation factor XI precursor [Homo sapiens]

2160 NP_000119 6 1 4503627 N-Term(iTRAQ4plex); C4(Methylthio); K7(iTRAQ4plex)

1.296 3 11.4 1.071 3 7.5 1.265 3 24.3 1.297 3 10.1 1.491 3 29.6 1.483 3 17 1.179 3 4.4 42 0 2 556.80695 1.77 14.49 1112.61077

WFYIASAFR ORM2;ORM1

alpha-1-acid glycoprotein 2 precursor [Homo sapiens];alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5005;5004 NP_000599;NP_000598

3 2 4505529;167857790

N-Term(iTRAQ4plex) 1.754 3 8 0.895 3 6.2 1.419 3 13.2 1.586 3 5.6 1.855 3 17.6 1.97 3 25.5 1.196 3 16.7 40 6.38 0 3 650.68494 -1.72 16.24 1950.04026

WGQLLLPSLLDLHLPR SERPINA11 serpin A11 precursor [Homo sapiens]

256394 NP_001073920 XP_170754

4 1 122937297 N-Term(iTRAQ4plex) 1.393 2 58.8 1.762 2 13.9 1.342 2 69.9 0.762 2 89.8 2.495 2 37.5 1.417 2 53.5 1.86 2 27.3 38 6.27 1 4 932.02484 0.75 80.59 3741.06899

WGTVCDDNFNIDHASVICR CD163 scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor [Homo sapiens]

9332 NP_981961 2 2 344179112 N-Term(iTRAQ4plex); C5(Methylthio); C18(Methylthio)

1.19 2 3.6 1.114 2 3.3 1.152 2 6.1 1.034 2 2.8 1.363 2 4.8 1.224 2 1.4 1.183 2 1.4 37 4.36 0 3 558.27454 -2.67 17 1672.80906

WGYCLEPK F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 12 1 145275213 N-Term(iTRAQ4plex); C4(Methylthio); K8(iTRAQ4plex)

1.235 6 9.7 0.98 6 11.7 1.152 6 14.1 1.181 6 6.3 1.327 6 13.5 1.387 6 2.2 1.121 6 3.6 37 3.82 0 2 609.302 0.45 53.12 1217.59148

WIISSLTPK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 4 1 105990535 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.625 9 6.1 0.985 9 17.9 1.459 9 13.8 1.556 9 8.5 1.66 9 12.6 1.74 9 7.8 1.138 9 1.8 34 0 2 556.80695 1.77 14.49 1128.60124

WILLEDYR CECR1 adenosine deaminase CECR1 isoform a precursor [Homo sapiens]

51816 NP_059120 2 1 29029550 N-Term(iTRAQ4plex) 1.775 2 13.5 0.946 2 2.1 1.594 2 13 1.684 2 15.1 1.861 2 12 1.966 2 14.1 1.168 2 1.1 33 5.56 0 4 558.27454 -2.67 17 1688.80507

WILTAAHTIYPK C1RL;C1R complement C1r subcomponent-like protein precursor [Homo sapiens];complement C1r subcomponent precursor [Homo sapiens]

51279;715 NP_057630;NP_001724 XP_930935 XP_935774

19 2 289547636;66347875

N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.525 1 0.846 1 1.29 1 1.526 1 1.524 1 1.802 1 1.181 1 29 0 2 471.27457 5.29 19.96 941.54186

WIVTAAHCVETGVK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 6 1 4503649 N-Term(iTRAQ4plex); C8(Methylthio); K14(iTRAQ4plex)

1.539 1 0.967 1 1.466 1 1.517 1 1.561 1 1.615 1 1.065 1 27 0 2 609.302 0.45 53.12 1233.59038

WIYHLTEGSTDLR APOM;APOM

apolipoprotein M isoform 2 [Homo sapiens];apolipoprotein M isoform 2 [Homo sapiens]

55937;55937

NP_001243098;NP_001243098

4 2 22091452;371873523

N-Term(iTRAQ4plex) 1.186 1 0.672 1 0.98 1 1.458 1 1.004 1 1.494 1 1.024 1 5.29 1 4 1116.9224 2.51 80.18 3364.73745

WKETLFSVMPGLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

43 2 31542984;262050538

N-Term(iTRAQ4plex); K2(iTRAQ4plex); K13(iTRAQ4plex)

1.343 17 5.4 0.954 17 4.1 1.216 17 6.7 1.3 17 5.3 1.384 17 4.8 1.474 17 5.7 1.137 17 2.5 3.23 0 2 537.79547 -1.52 34.46 1074.58367

WKETLFSVMPGLK ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

5 2 31542984;262050538

N-Term(iTRAQ4plex); K2(iTRAQ4plex); M9(Oxidation); K13(iTRAQ4plex)

1.404 1 1.037 1 1.364 1 1.316 1 1.495 1 1.442 1 1.096 1 2.93 0 2 507.77802 -0.16 33.14 1014.54875

WKNFPSPVDAAFR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 14 1 11321561 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.985 37 36.9 0.917 37 19.4 1.821 37 23 1.98 37 41.5 2.172 37 28.8 2.19 37 45.1 1.165 37 9.7 118 7.93 0 3 986.03864 -4.09 39.93 1971.06999

WLILEK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 143 1 115298678 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

2.228 23 13.1 1.038 23 12.7 2.017 23 24.8 2.039 23 18.5 2.428 23 25.9 2.33 23 10.5 1.114 23 3.8 116 6 0 2 885.96307 -1.79 32.59 1770.91777

WLNVQLSPR CPN2 carboxypeptidase N subunit 2 precursor [Homo sapiens]

1370 NP_001073982 XP_930891

7 1 256217721 N-Term(iTRAQ4plex) 3.852 6 17.9 0.937 6 7.1 3.682 6 18.1 3.749 6 13.8 3.936 6 23.6 4.004 6 13.1 1.108 6 5.5 110 4.11 0 2 885.96307 -1.79 32.59 1786.90984

WLPSSSPVTGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

24 5 47132549;16933542

N-Term(iTRAQ4plex) 2.056 91 26 0.95 91 14.1 1.847 91 27.2 2.093 91 20.3 2.157 91 25.6 2.359 91 19 1.134 91 5.8 95 5.34 0 2 803.51288 0.16 80.07 1606.01909

WLQDNAENVYVWK GP1BA platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

2811 NP_000164 6 1 291190772 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.437 7 17.6 0.919 7 15.3 1.947 7 4 2.639 7 13.1 2.57 7 13.3 2.999 7 35.8 1.303 7 19.4 93 9.33 0 3 1076.2568 8.88 81.89 3226.75595

WLSEEQR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex) 2.202 25 28.9 0.943 25 21.1 1.845 25 37.5 2.139 25 20.6 2.029 25 36.2 2.479 25 21.3 1.122 25 6.4 89 5.46 0 2 941.49292 -4.53 42.95 1881.97991

WLTFSLGK MBL2 mannose-binding protein C precursor [Homo sapiens]

4153 NP_000233 13 1 4557739 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

6.588 2 21.2 0.777 2 34.9 5.81 2 1.2 7.482 2 36.2 5.962 2 11.1 7.678 2 47.3 1.026 2 9.9 86 4.68 0 3 885.96307 -1.79 32.59 1802.9097

WLTPFDPVFTEVDTFHLDK SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 23 1 7705879 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

2.637 4 27.1 1 4 13.3 2.29 4 33 2.566 4 21.1 2.706 4 42 3.032 4 14.1 1.129 4 5.6 79 4.62 0 2 941.49292 -4.53 42.95 1897.97453

WLVGEMHCQK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 8 1 45580688 N-Term(iTRAQ4plex); C8(Methylthio); K10(iTRAQ4plex)

2.464 2 32.7 1.213 2 89.3 2.71 2 18 2.234 2 64.2 2.917 2 2.7 2.405 2 85.2 1.076 2 15.2 77 9.26 0 3 1076.2568 8.88 81.89 3242.7396

WNDDFCLQVYR ASGR2 asialoglycoprotein receptor 2 isoform b [Homo sapiens]

433 NP_550435 2 4 18426875 N-Term(iTRAQ4plex); C6(Methylthio)

2.551 9 14.2 0.941 9 12.8 1.983 9 12.6 2.65 9 19.7 2.328 9 8.9 2.9 9 28 1.113 9 5.8 75 5.53 0 3 860.48712 -0.16 27.33 1719.96823

WNFAYWAAHQPWSR PRG2 bone marrow proteoglycan isoform 2 preproprotein [Homo sapiens]

5553 NP_001230174 2 2 342837699 N-Term(iTRAQ4plex) 1.978 6 16.8 0.871 6 47.1 1.607 6 17.6 1.96 6 33.5 2.026 6 11.8 2.409 6 33.6 1.245 6 11.4 73 7.69 0 3 968.53998 -0.31 75.02 2903.60501

WNFEK GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 1 3 6006001 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

2.233 20 26 1.002 20 11.4 1.968 20 21.5 2.024 20 25.7 2.181 20 24.4 2.23 20 27.3 1.111 20 4.2 72 5.03 0 2 776.94507 0.23 33.91 1552.86382

WNFYYSPQSSPDK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 28 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

2.103 10 13.4 0.974 10 10 1.817 10 14.9 2.068 10 17.8 2.168 10 10.7 2.362 10 15.5 1.147 10 10.5 70 6.48 1 4 996.59485 9.11 25.08 1992.18242

WNFYYSPQSSPDKK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K13(iTRAQ4plex); K14(iTRAQ4plex)

2.415 2 21 0.839 2 11.7 2.112 2 30.9 2.517 2 18.7 2.331 2 22.7 2.777 2 10.8 1.103 2 7.8 69 3.15 0 2 553.85559 1.4 25.86 1106.70391

WNNYMMDWK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 6 1 4557351 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.729 2 77.3 0.742 2 30.2 1.527 2 49.9 2.057 2 17.7 1.417 2 172.8 1.909 2 108.1 0.928 2 80.2 65 10.52 1 5 700.59088 0.27 81.46 3498.9253

WNNYMMDWK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 1 1 4557351 N-Term(iTRAQ4plex); M5(Oxidation); M6(Oxidation); K9(iTRAQ4plex)

2.286 6 8.5 1.089 6 4.1 2.313 6 5.1 2.057 6 17.7 2.466 6 5.1 2.262 6 11.5 1.093 6 3.8 63 5.11 0 2 748.38226 -4.51 19.92 1495.75725

WNNYMMDWK BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 1 1 4557351 N-Term(iTRAQ4plex); M5(Oxidation); K9(iTRAQ4plex)

2.398 3 7.1 0.943 3 3.2 2.356 3 72.4 1.776 3 58 2.48 3 20.6 2.293 3 23.9 1.053 3 6.5 55 8.77 1 4 700.59088 0.27 81.46 3514.92519

WNPEVDCTEK CFHR5 complement factor H-related protein 5 precursor [Homo sapiens]

81494 NP_110414 4 1 13540563 N-Term(iTRAQ4plex); C7(Methylthio); K10(iTRAQ4plex)

2.302 2 4.6 0.945 2 2.2 2.083 2 2 2.205 2 4.2 2.394 2 4.8 2.533 2 7 1.149 2 2.8 53 5.8 1 3 1088.0892 11.06 28.86 2175.16623

WNPSPPACEPNSCINLPDIPHASWETYPRPTK

C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 1 1 4502503 N-Term(iTRAQ4plex); C8(Methylthio); C13(Methylthio); K32(iTRAQ4plex)

2.429 16 11.7 0.966 16 8.2 2.303 16 15.9 2.472 16 10.7 2.496 16 13.2 2.65 16 6.2 1.088 16 5.9 51 4.02 0 2 665.40533 1.7 48.89 1329.79802

WNYIEGTK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 6 1 21071039 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.844 6 4.4 1.014 6 8.7 1.746 6 11 1.808 6 14.6 2.068 6 8.2 2.048 6 12.7 1.136 6 3.9 50 0 2 555.79785 -0.52 12.41 1110.58843

WQEEMELYR APOA1 apolipoprotein A-I preproprotein [Homo sapiens]

335 NP_000030 3 1 4557321 N-Term(iTRAQ4plex); M5(Oxidation)

2.547 1 0.93 1 2.375 1 2.554 1 2.54 1 2.731 1 1.069 1 48 1 2 1088.0892 11.06 28.86 2191.16338

WQSIPLCVEK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 75 1 62739186 N-Term(iTRAQ4plex); C7(Methylthio); K10(iTRAQ4plex)

2.493 6 5.8 1.043 6 4 2.278 6 8.7 2.252 6 14.6 2.577 6 10.1 2.582 6 12.6 1.12 6 4.7 44 2.86 0 2 527.78699 1.65 22.61 1054.56548

WSAETPHKPQFTFTSEPHAQLEENFCR

MST1 hepatocyte growth factor-like protein precursor [Homo sapiens]

4485 NP_066278 2 1 205277383 N-Term(iTRAQ4plex); K8(iTRAQ4plex); C26(Methylthio)

2.032 10 28.6 0.984 10 9.3 1.764 10 23.8 1.94 10 26.5 2.032 10 33.3 2.139 10 31.1 1.095 10 6.9 43 3.49 0 2 630.84814 -2.09 37.92 1260.68901

WSAGLTSSQVDLYIPK SERPINA6 corticosteroid-binding globulin precursor [Homo sapiens]

866 NP_001747 33 1 73858564 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

2.623 1 0.849 1 2.224 1 2.62 1 2.626 1 3.093 1 1.181 1 35 0 3 413.88419 -4.41 16.65 1239.638

WSGQTAICDNGAGYCSNPGIPIGTR

CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 8 1 67782358 N-Term(iTRAQ4plex); C8(Methylthio); C15(Methylthio)

2.416 2 7.3 0.983 2 15.8 2.26 2 17.1 2.3 2 1.3 2.536 2 13.5 2.581 2 2.3 1.122 2 3.6 33 0 2 440.26508 1.87 12.8 879.52287

WSHPPSCIK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 5 1 62739186 N-Term(iTRAQ4plex); C7(Methylthio); K9(iTRAQ4plex)

1.152 1 1.093 1 1.144 1 1.047 1 1.268 1 1.16 1 1.108 1 6.13 1 4 935.2663 4.27 80.19 3738.04336

WSPELPVCAPIICPPPSIPTFATLR

APOH beta-2-glycoprotein 1 precursor [Homo sapiens]

350 NP_000033 105 1 153266841 N-Term(iTRAQ4plex); C8(Methylthio); C13(Methylthio)

1.231 1 0.747 1 0.892 1 1.194 1 1.258 1 1.683 1 1.41 1 60 3.68 0 3 844.44678 -1.12 76.89 2531.32578

WSRPQAPITGYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex) 1.699 1 0.856 1 1.414 1 1.652 1 1.739 1 2.031 1 1.23 1 64 6.33 0 3 689.34723 -0.75 44.62 2066.02713

WSSPPQCEGLPCK CFH complement factor H isoform a precursor [Homo sapiens]

3075 NP_000177 68 1 62739186 N-Term(iTRAQ4plex); C7(Methylthio); C12(Methylthio); K13(iTRAQ4plex)

1.108 2 13 0.878 2 6.7 0.967 2 10.3 1.102 2 3.5 1.112 2 21.5 1.267 2 14.6 1.15 2 11 51 3.96 0 2 745.42706 -1.82 46.2 1489.8488

WSVLPRPDLHHDVNR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 2 3 21450863 N-Term(iTRAQ4plex) 1.084 1 0.832 1 0.999 1 1.201 1 0.986 1 1.186 1 0.987 1 35 2.9 0 2 664.85077 -1.84 37.88 1328.69426

WTEPPK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 1 1 110611237 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

0.954 1 0.792 1 0.84 1 1.061 1 0.869 1 1.098 1 1.035 1 3.78 0 2 913.01428 4.57 70.71 1825.02129

WTLLQEQGTK KRT5;KRT6A

keratin, type II cytoskeletal 5 [Homo sapiens];keratin, type II cytoskeletal 6A [Homo sapiens]

3852;3853 NP_000415;NP_005545 NP_490596

2 4 119395754;5031839

N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.766 1 1.102 1 1.598 1 1.451 1 2.113 1 1.919 1 1.322 1 3.89 1 4 832.70013 19.9 28.94 3327.77871

WTLPPECVENNENCK F13B coagulation factor XIII B chain precursor [Homo sapiens]

2165 NP_001985 16 1 110611237 N-Term(iTRAQ4plex); C7(Methylthio); C14(Methylthio); K15(iTRAQ4plex)

1.67 1 0.884 1 1.448 1 1.639 1 1.698 1 1.921 1 1.172 1 3.42 1 3 801.81073 7.59 60.65 2403.41764

WTLTAPPGYR MASP2 mannan-binding lectin serine protease 2 isoform 2 precursor [Homo sapiens]

10747 NP_631947 2 2 21264361 N-Term(iTRAQ4plex) 1.027 1 0.915 1 0.901 1 0.984 1 1.066 1 1.165 1 1.183 1 72 3.64 0 2 820.43903 -4.5 36.22 1639.87078

WTPYQGCEALCCPEPK C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 20 1 4502503 N-Term(iTRAQ4plex); C7(Methylthio); C11(Methylthio); C12(Methylthio); K16(iTRAQ4plex)

1.199 1 1.11 1 1.21 1 1.09 1 1.32 1 1.188 1 1.091 1 65 3.67 0 2 624.86804 -0.14 32.59 1248.72881

WTSFLK SEMA4B;SEMA4G

semaphorin-4B precursor [Homo sapiens];semaphorin-4G isoform 2 precursor [Homo sapiens]

10509;57715

NP_064595;NP_001190173

1 5 39777608;322302953

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.356 1 0.952 1 1.244 1 1.306 1 1.404 1 1.474 1 1.128 1 46 3.74 0 2 675.8866 2.89 20.41 1350.76592

WVATGIVSWGIGCSR C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

28 1 66347875 N-Term(iTRAQ4plex); C13(Methylthio)

0.949 1 1.077 1 0.948 1 0.88 1 1.024 1 0.951 1 1.08 1 42 3.03 0 2 610.84119 -1.19 32.01 1220.6751

WVDGTDYR ASGR2 asialoglycoprotein receptor 2 isoform b [Homo sapiens]

433 NP_550435 1 4 18426875 N-Term(iTRAQ4plex) 1.257 1 0.864 1 1.124 1 1.302 1 1.219 1 1.411 1 1.084 1 29 3.97 0 3 593.94781 0.78 26.7 1779.82889

WVEELMK ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 4 3 91823602 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.361 1 1.034 1 1.283 1 1.241 1 1.485 1 1.437 1 1.158 1 32 2.96 0 2 631.78424 -0.44 20.02 1262.5612

WVFKEEDPIHLR FCGR3A;FCGR3B

low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor [Homo sapiens];low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor [Homo sapiens]

2214;2215 NP_001121068;NP_000561

2 6 189083842;132814489

N-Term(iTRAQ4plex); K4(iTRAQ4plex)

1.104 1 0.89 1 0.957 1 1.075 1 1.129 1 1.269 1 1.18 1 35 0 2 530.3045 9.62 26.2 1059.60173

WVLTAAHCLLYPPWDK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 9 1 4503635 N-Term(iTRAQ4plex); C8(Methylthio); K16(iTRAQ4plex)

1.684 2 16.1 2.382 2 294.8 2.587 2 151.8 1.086 2 43.2 3.727 2 202.1 1.565 2 23.5 1.44 2 18.4 59 3.91 0 3 701.08246 -1.47 75.13 2101.23282

WVMVPMMSLHHLTIPYFR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 18 1 50659080 N-Term(iTRAQ4plex); M7(Oxidation)

1.955 1 0.784 1 1.704 1 2.173 1 1.784 1 2.274 1 1.047 1 3.8 1 4 774.44458 16.91 80.07 3094.75649

WVMVPMMSLHHLTIPYFR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 38 1 50659080 N-Term(iTRAQ4plex) 1.407 1 0.922 1 1.177 1 1.276 1 1.527 1 1.655 1 1.297 1 3.44 0 3 866.79083 7.09 39.7 2598.35794

WVMVPMMSLHHLTIPYFR SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 12 1 50659080 N-Term(iTRAQ4plex); M3(Oxidation); M6(Oxidation)

1.494 1 0.903 1 1.317 1 1.459 1 1.526 1 1.691 1 1.158 1 33 0 2 430.7955 3.43 14.52 860.58373

WVQDYIK CCL14 C-C motif chemokine 14 isoform 1 precursor [Homo sapiens]

6358 NP_116739 3 2 14589961 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.609 13 14.8 0.882 13 25.1 1.39 13 19.8 1.881 13 25.3 1.53 13 10.3 1.709 13 33.1 1.098 13 20 122 7.78 0 3 978.52979 -1.72 75.15 2933.5748

WVQTLSEQVQEELLSSQVTQELR

APOE apolipoprotein E precursor [Homo sapiens]

348 NP_000032 12 1 4557325 N-Term(iTRAQ4plex) 1.667 14 19.3 1.032 14 12.6 1.556 14 24.4 1.659 14 14.2 1.787 14 29.1 1.885 14 13.3 1.124 14 3.9 76 4.75 0 2 710.34125 -6.95 21.7 1419.67522

WVVQGLVSWGGPEECGSK MASP1 mannan-binding lectin serine protease 1 isoform 3 precursor [Homo sapiens]

5648 NP_001027019 4 1 21264359 N-Term(iTRAQ4plex); C15(Methylthio); K18(iTRAQ4plex)

1.388 1 0.936 1 1.31 1 1.4 1 1.377 1 1.472 1 1.051 1 56 4.39 0 3 825.08026 4.26 71.98 2473.22623

WWDIIDIQK MAN2A1 alpha-mannosidase 2 [Homo sapiens]

4124 NP_002363 1 1 51477714 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.792 4 68.6 1.029 3 8.8 1.229 4 6.2 1.113 2 1.8 1.344 4 6.8 1.177 2 13.7 1.028 4 8.5 45 6.51 1 3 915.81061 1.65 51.58 2745.41727

WWGGQPLWITATK ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein [Homo sapiens]

5168 NP_001035181 2 3 91823602 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.449 7 7.3 0.978 7 1.9 1.358 7 7.2 1.387 7 5.4 1.451 7 8.3 1.496 7 4.3 1.117 7 2.3 97 5.57 0 2 927.98914 -0.47 65.93 1854.96977

WYADCTSAGR LOC100652938

PREDICTED: macrophage mannose receptor 1-like [Homo sapiens]

100652938 XP_003403495 2 2 341915493 N-Term(iTRAQ4plex); C5(Methylthio)

1.516 12 4.3 0.936 12 13.6 1.347 12 10.2 1.458 12 11.5 1.58 12 7.9 1.641 12 6.2 1.161 12 7 91 8.58 0 3 865.78925 6.07 62.63 2595.33542

WYLFGMGNEVDVHAAFFHGQALTNK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 110 1 4557485 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.712 2 11.8 0.87 2 28.7 1.467 2 26.8 1.685 2 1.8 1.75 2 24 2.01 2 4.5 1.193 2 2.7 87 9.18 0 3 688.3927 5.19 43.96 2063.15238

WYLFGMGNEVDVHAAFFHGQALTNK

CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 64 1 4557485 N-Term(iTRAQ4plex); M6(Oxidation); K25(iTRAQ4plex)

2.161 1 1.105 1 2.369 1 2.143 1 2.18 1 1.973 1 0.92 1 86 6.1 0 3 851.1358 -0.16 73.13 2551.39286

Page 45: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

WYNLAIGSTCPWLK AMBP protein AMBP preproprotein [Homo sapiens]

259 NP_001624 54 1 4502067 N-Term(iTRAQ4plex); C10(Methylthio); K14(iTRAQ4plex)

2.395 2 16 1.226 2 21.5 2.683 2 31.5 2.188 2 9.5 2.661 2 24.8 2.17 2 3.2 0.992 2 6.3 74 7.19 0 3 884.44373 0.82 72.01 2651.30857

WYQMGIVSWGEGCDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 72 1 4503635 N-Term(iTRAQ4plex); C13(Methylthio)

1.496 6 16.8 1.001 6 10.9 1.419 6 25.3 1.407 6 3.8 1.6 6 28.7 1.661 6 8.8 1.142 6 3.5 74 4.25 0 2 747.40808 -0.09 28.38 1493.80901

WYQMGIVSWGEGCDR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 32 1 4503635 N-Term(iTRAQ4plex); M4(Oxidation); C13(Methylthio)

1.386 11 14.9 1.016 11 16.5 1.406 11 43.2 1.311 11 44.6 1.497 11 23.7 1.556 11 25.6 1.05 11 29.4 72 7.4 0 3 884.44373 0.82 72.01 2635.32236

WYQMGIVSWGEGCDRDGK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 2 1 4503635 N-Term(iTRAQ4plex); C13(Methylthio); K18(iTRAQ4plex)

1.398 14 21.6 0.889 14 16 1.277 14 22.3 1.334 14 19.5 1.47 14 23.1 1.526 14 20.8 1.141 14 4.3 61 4.52 0 2 762.98669 1.12 65.58 1524.96599

WYQMGIVSWGEGCDRDGK F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 2 1 4503635 N-Term(iTRAQ4plex); M4(Oxidation); C13(Methylthio); K18(iTRAQ4plex)

1.354 1 0.992 1 1.307 1 1.317 1 1.39 1 1.401 1 1.063 1 55 3.83 0 3 412.21808 2.1 19.14 1234.63968

WYYDPNTK COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 1 3 55743098 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.399 2 0.6 0.871 2 18.7 1.217 2 9.6 1.398 2 8.9 1.406 2 8.9 1.614 2 9.6 1.155 2 0.7 52 4.97 0 2 707.87463 -1.95 50.92 1414.74199

YAASSYLSLTPEQWK IGLL5 immunoglobulin lambda-like polypeptide 5 isoform 2 [Homo sapiens]

100423062 NP_001243225 7 2 372466586 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.764 1 0.999 1 1.753 1 1.755 1 1.773 1 1.774 1 1.011 1 48 3.28 0 2 864.36896 -2.44 49.8 1727.73064

YADAQLSCQGR COLEC11 collectin-11 isoform j [Homo sapiens]

78989 NP_001242918 2 10 364502955 N-Term(iTRAQ4plex); C8(Methylthio)

1.291 1 0.839 1 1.128 1 1.344 1 1.247 1 1.486 1 1.105 1 47 3.56 0 2 650.35059 -5.46 30.87 1299.6939

YAFELK C9 complement component C9 precursor [Homo sapiens]

735 NP_001728 7 2 4502511 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.621 2 0.3 0.919 2 12.8 1.449 2 5.8 1.576 2 6.9 1.665 2 6.8 1.812 2 5.9 1.149 2 1 44 3.51 0 2 552.80493 0.74 16.44 1104.60259

YAFVNWINK LCP1 plastin-2 [Homo sapiens] 3936 NP_002289 5 3 167614506 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.192 1 0.885 1 0.996 1 1.125 1 1.251 1 1.413 1 1.256 1 32 4.3 0 2 864.36896 -2.44 49.8 1711.74126

YAGSQVASTSEVLK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 4 1 89191868 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.486 1 1.107 1 1.393 1 1.259 1 1.738 1 1.57 1 1.247 1 6.5 0 5 547.75201 4.22 36.11 2734.73096

YALSNSIGPVR NID1 nidogen-1 precursor [Homo sapiens]

4811 NP_002499 2 1 115298674 N-Term(iTRAQ4plex) 1.089 1 0.969 1 0.972 1 1.004 1 1.172 1 1.21 1 1.205 1 64 3.7 0 2 703.35931 -5.62 18.81 1405.71135

YAPISGGDHAEVDVPK TNC tenascin precursor [Homo sapiens] 3371 NP_002151 1 1 153946395 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.168 1 0.917 1 1.039 1 1.133 1 1.201 1 1.31 1 1.156 1 2.86 0 2 649.40161 -0.09 46.96 1297.79595

YAVDDVQYVDEIASVLTSQKPSVLLTLR

PEPD xaa-Pro dipeptidase isoform 1 [Homo sapiens]

5184 NP_000276 NP_116041

12 2 149589008 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.86 5 1.1 1.068 5 15.6 1.828 5 9.6 1.853 5 3.9 2.086 5 1.2 1.968 5 6.1 1.084 5 4.3 112 5.63 0 2 868.3913 1.57 23.91 1735.76482

YAVSEAAAHK FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 4 2 27754776 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.156 6 7.4 0.937 6 8.6 1.083 6 5.1 1.131 6 9.6 1.197 6 10 1.294 6 8.1 1.116 6 8.6 100 5.76 0 3 1125.0684 1.56 64.55 2249.13041

YAYLLQPSQFHGEPCNFSDK

C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 13 1 4557391 N-Term(iTRAQ4plex); C15(Methylthio); K20(iTRAQ4plex)

1.803 4 13 0.935 4 22.3 1.746 4 13.4 1.647 4 2 1.912 4 12.6 1.937 4 7.3 1.134 4 5.4 94 5.61 0 2 863.0036 -2.19 61.64 1724.99993

YCESIMR ANG angiogenin precursor [Homo sapiens]

283 NP_001136 1 1 4557313 N-Term(iTRAQ4plex); C2(Methylthio)

1.583 4 6.6 0.903 4 6.4 1.439 4 11.9 1.571 4 8.7 1.611 4 5 1.721 4 2.5 1.098 4 6 92 5.49 0 2 802.40997 -4.37 33.1 1603.81841

YCVQLSQIQAQISALEEQLQQIR

KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

2 2 195972866 N-Term(iTRAQ4plex); C2(Methylthio)

1.831 3 2.7 0.753 3 14.3 1.523 3 22 1.855 3 21.6 1.56 3 27.6 1.97 3 22 1.027 3 0.3 89 5.61 0 3 1099.4689 2.21 38.82 2197.92093

YDALEVFAGSGTSGQR PCOLCE procollagen C-endopeptidase enhancer 1 precursor [Homo sapiens]

5118 NP_002584 4 1 157653329 N-Term(iTRAQ4plex) 1.787 6 17.8 1.012 6 7.4 1.686 6 13.1 1.627 6 13.5 1.957 6 22.7 1.934 6 30.4 1.088 6 4 88 5.76 0 3 1125.0684 1.56 64.55 2265.12009

YDKNQDVHSINLPFFETLQEYFER

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 8 1 105990532 N-Term(iTRAQ4plex); K3(iTRAQ4plex)

1.571 12 15.2 0.977 12 16 1.535 12 19.5 1.49 12 10.1 1.65 12 20 1.65 12 11.6 1.122 12 5.4 88 4.49 0 3 910.97461 -3.83 31.58 1820.94303

YDLAFVVASQATK FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.346 9 4.6 0.988 9 19.5 1.333 9 15.7 1.312 9 9.4 1.457 9 11.1 1.433 9 9.1 1.125 9 5.4 82 5 0 2 781.35669 -1.56 25.71 1561.69426

YDLLDLTR NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 1 1 66346698 N-Term(iTRAQ4plex) 1.521 11 9.8 0.953 11 4.4 1.396 11 8.9 1.483 11 8.3 1.544 11 8.1 1.675 11 9.2 1.136 11 2 76 4.28 0 2 769.88397 1.96 36.94 1538.75591

YDLSALVR IGF2R cation-independent mannose-6-phosphate receptor precursor [Homo sapiens]

3482 NP_000867 1 1 119964726 N-Term(iTRAQ4plex) 1.614 26 13.2 0.947 26 18.5 1.438 26 20.7 1.602 26 6.9 1.665 26 22.1 1.81 26 6.7 1.119 26 3.9 73 5.12 0 2 842.94385 -3.26 54.06 1684.89214

YDSTCER C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 2 1 4557389 N-Term(iTRAQ4plex); C5(Methylthio)

1.452 4 4.6 1.043 4 16.9 1.361 4 5.3 1.259 4 7.9 1.571 4 7.5 1.584 4 9.1 1.123 4 16.6 73 5.94 0 3 1229.0764 -0.09 57.29 2457.14133

YDVDR ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

2 2 31542984;262050538

N-Term(iTRAQ4plex) 1.197 2 11.2 0.778 2 24 0.972 2 1.1 1.249 2 25.1 1.163 2 0.6 1.495 2 24.6 1.197 2 0.5 70 6.13 0 3 1099.4689 2.21 38.82 2181.93143

YDVDTQMWTILK ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 11 3 21450863 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.543 2 10.3 0.854 2 26.6 1.349 2 24.2 1.58 2 2.2 1.522 2 21.1 1.782 2 5.2 1.128 2 3 69 4.33 0 2 690.38995 -3.4 15.39 1379.77263

YDVENCLANK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 16 1 66932947 N-Term(iTRAQ4plex); C6(Methylthio); K10(iTRAQ4plex)

1.429 3 6.4 1.223 3 4.1 1.298 3 2.3 1.061 3 1.9 1.879 3 18.8 1.537 3 3.1 1.448 3 8.7 62 5.59 0 3 1003.8158 1.88 35.84 3009.42936

YDYCDILECEEECMHCSGENYDGK

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 42 1 4505881 N-Term(iTRAQ4plex); C4(Methylthio); C9(Methylthio); C13(Methylthio); C16(Methylthio); K24(iTRAQ4plex)

1.313 1 0.898 1 1.182 1 1.316 1 1.311 1 1.46 1 1.109 1 57 6.71 0 3 647.98169 3.87 40.09 1941.93052

YECVATNSAGTR PTPRF receptor-type tyrosine-protein phosphatase F isoform 2 precursor [Homo sapiens]

5792 NP_569707 2 8 109633039 N-Term(iTRAQ4plex); C3(Methylthio)

1.57 2 6.1 0.969 2 1.1 1.431 2 4.7 1.477 2 5.8 1.659 2 6.2 1.713 2 7.3 1.159 2 1.5 57 4 0 2 603.35754 8.13 15.69 1205.70793

YEDGTLSLTSTSDLQSGIIK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 91 1 105990532 N-Term(iTRAQ4plex); K20(iTRAQ4plex)

1.529 2 3.9 1.011 2 7.5 1.465 2 10.8 1.45 2 3.2 1.609 2 4.8 1.592 2 2.7 1.098 2 5.9 56 3.4 0 2 554.28693 7.27 25.38 1107.56658

YEDLYSNCK CRISP3 cysteine-rich secretory protein 3 isoform 1 precursor [Homo sapiens]

10321 NP_006052 14 2 300244560 N-Term(iTRAQ4plex); C8(Methylthio); K9(iTRAQ4plex)

1.747 4 16.6 1.16 4 25.9 1.802 4 27.5 1.508 4 4.4 1.972 4 29.6 1.7 4 3.6 1.121 4 3.6 54 4.06 0 2 665.8891 -16.82 22.29 1330.77092

YEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIR

MINPP1 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor [Homo sapiens]

9562 NP_004888 2 2 19923761 N-Term(iTRAQ4plex); C26(Methylthio)

1.458 2 7.4 0.848 2 13.9 1.179 2 6.6 1.39 2 7.3 1.516 2 19.5 1.787 2 5.5 1.285 2 12.8 48 4.1 0 3 691.98456 -0.26 74.1 2073.93912

YEELQITAGR KRT1 keratin, type II cytoskeletal 1 [Homo sapiens]

3848 NP_006112 8 3 119395750 N-Term(iTRAQ4plex) 1.711 6 12.2 0.962 6 16.6 1.53 6 21.4 1.654 6 5.5 1.776 6 14.6 1.856 6 6.6 1.113 6 8 46 3.45 0 2 605.34021 1.13 12.83 1209.67266

YEELQQTAGR KRT5 keratin, type II cytoskeletal 5 [Homo sapiens]

3852 NP_000415 3 1 119395754 N-Term(iTRAQ4plex) 1.451 3 0.2 0.953 3 1.2 1.392 3 12.3 1.473 3 0.9 1.546 3 4 1.553 3 3.9 1.048 3 3 41 3.54 0 2 655.84137 2.81 34.86 1310.67095

YEELQVTAGR KRT6A keratin, type II cytoskeletal 6A [Homo sapiens]

3853 NP_005545 NP_490596

4 3 5031839 N-Term(iTRAQ4plex) 1.547 1 1.184 1 1.592 1 1.344 1 1.787 1 1.509 1 1.123 1 39 4.36 1 2 866.52075 0.74 19.92 1732.03423

YEELQVTVGR KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 4 2 47132620 N-Term(iTRAQ4plex) 1.671 3 16.4 0.92 3 28.3 1.362 3 10.8 1.681 3 12.8 1.551 3 24.3 1.864 3 16.8 1.109 3 4 37 4.69 0 3 723.42554 5.75 16.45 1445.83692

YEFILK C8B complement component C8 beta chain preproprotein [Homo sapiens]

732 NP_000057 4 1 4557391 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

2.221 1 0.957 1 2.04 1 2.132 1 2.306 1 2.41 1 1.131 1 35 0 2 554.28693 7.27 25.38 1123.55327

YEFLNGR PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 1 1 4505881 N-Term(iTRAQ4plex) 1.187 1 1.127 1 1.225 1 1.087 1 1.301 1 1.154 1 1.062 1 4.41 1 3 455.92966 1.11 10.46 1365.77442

YEGLQEWEGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 2 1 105990532 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.516 1 0.953 1 1.42 1 1.491 1 1.539 1 1.616 1 1.084 1 3.67 0 2 671.83679 5.79 16.56 1342.66631

YEITTIHNLFR SERPIND1 heparin cofactor 2 precursor [Homo sapiens]

3053 NP_000176 96 1 73858566 N-Term(iTRAQ4plex) 0.219 2 9.1 0.983 2 3.7 0.193 2 14.6 0.196 2 10.9 0.241 2 7.9 0.245 2 4.3 1.249 2 6.6 88 5.76 0 2 996.0025 -1.18 43.36 1990.99773

YEIVVEAR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 4 1 166362713 N-Term(iTRAQ4plex) 0.467 2 389.2 0.991 2 1.4 0.464 2 332.5 0.468 2 340.4 0.464 2 446.8 0.468 2 458 1 2 16.8 67 8 0 3 896.12793 -0.53 49.47 2686.36924

YEKPGSPPR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

2 5 47132549;16933542

N-Term(iTRAQ4plex); K3(iTRAQ4plex)

0.144 1 0.91 1 0.122 1 0.134 1 0.152 1 0.167 1 1.248 1 51 2.96 0 2 601.30042 -2.87 19.81 1201.59355

YELDK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.273 1 1.126 1 1.207 1 1.072 1 1.5 1 1.333 1 1.243 1 79 3.98 0 2 811.3822 -0.25 22.65 1621.75713

YEMHELLR SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 2 1 7705879 N-Term(iTRAQ4plex) 1.065 1 0.985 1 0.972 1 0.987 1 1.142 1 1.16 1 1.175 1 3.18 0 2 834.44257 -18.4 20.99 1667.87786

YEMYLK ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 4 1 133925809 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.321 1 0.653 1 1.03 1 1.577 1 1.153 1 1.766 1 1.119 1 4.01 2 4 716.13318 -4.33 47.03 2861.51088

YENEVALR KRT10 keratin, type I cytoskeletal 10 [Homo sapiens]

3858 NP_000412 XP_352920

1 2 195972866 N-Term(iTRAQ4plex) 1.565 1 0.997 1 1.495 1 1.499 1 1.631 1 1.636 1 1.091 1 29 0 2 423.28876 0.43 17.11 845.57024

YENYELTLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 32 1 105990532 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.193 4 5.1 1.079 4 5.4 1.153 4 22.6 1.08 4 8.5 1.374 4 11.5 1.325 4 11.2 1.192 4 12.8 94 6.14 0 2 830.99731 -2.22 44.93 1660.9887

YEVDQQIQVLMDK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); M11(Oxidation); K13(iTRAQ4plex)

1.242 5 10.8 0.876 5 19.8 1.136 5 14.5 1.144 5 1.5 1.324 5 14.9 1.511 5 24.2 1.316 5 0.6 92 6.88 0 3 1096.083 1.7 53.23 2191.15335

YEVSVYALK FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

17 5 47132549;16933542

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.158 2 3.2 0.831 2 28 1.004 2 7.1 1.209 2 20.6 1.122 2 23.7 1.351 2 4.1 1.117 2 16.4 71 11.16 0 4 1175.1211 -0.75 48.65 3523.35293

YEVTVVSVR TNXB tenascin-X isoform 1 precursor [Homo sapiens]

7148 NP_061978 4 2 188528648 N-Term(iTRAQ4plex) 1.144 5 8.6 1.017 5 18.2 1.108 5 14 1.144 5 17.1 1.042 5 17.5 1.237 5 13.1 1.085 5 12.5 67 4.91 0 2 908.39563 -2 59.17 1815.77666

YEYLEGGDR HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 3 1 4504383 N-Term(iTRAQ4plex) 0.851 4 33.8 0.894 4 12.9 0.793 4 34.6 0.812 4 26.1 0.818 4 47.7 0.909 4 32.3 1.172 4 9.7 58 3.58 0 2 682.89825 -9.94 21.08 1364.79827

YFDTECVPMNFR SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 2 1 7705879 N-Term(iTRAQ4plex); C6(Methylthio); M9(Oxidation)

0.851 1 0.899 1 0.771 1 0.857 1 0.845 1 0.94 1 1.096 1 57 4.44 0 2 877.37933 2.3 53.41 1753.75139

YFDTECVPMNFR SERPINA10 protein Z-dependent protease inhibitor precursor [Homo sapiens]

51156 NP_057270 2 1 7705879 N-Term(iTRAQ4plex); C6(Methylthio)

1.203 2 9.7 1.079 2 14.3 1.227 2 3.7 1.138 2 18.1 1.277 2 1 1.184 2 15.3 1.041 2 2.7 56 5.3 0 3 830.0058 0.54 44.71 2488.00284

YFIDFVAR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

61 3 4504893;156231037

N-Term(iTRAQ4plex) 1.085 4 12.5 0.973 4 12.5 0.973 4 8.7 1.088 4 14.8 1.106 4 4 1.209 4 4.5 1.111 4 9.2 55 4.36 0 3 925.43805 -0.3 31.22 1849.8638

YFKPGMPFDLMVFVTNPDGSPAYR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 47 1 115298678 N-Term(iTRAQ4plex); K3(iTRAQ4plex)

1.313 2 2.8 1.004 2 11.4 1.276 2 3 1.27 2 8.3 1.357 2 2.8 1.351 2 8.6 1.064 2 0.3 52 4.41 0 2 723.28558 -0.78 48.94 1445.56011

YFKPGMPFDLMVFVTNPDGSPAYR

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 24 1 115298678 N-Term(iTRAQ4plex); K3(iTRAQ4plex); M6(Oxidation)

1.2 1 0.968 1 1.12 1 1.156 1 1.242 1 1.283 1 1.109 1 46 4.87 0 2 1020.868 -4.53 28.89 2040.72881

YGAATFTR A2M;PZP alpha-2-macroglobulin precursor [Homo sapiens];pregnancy zone protein precursor [Homo sapiens]

2;5858 NP_000005;NP_002855

2 2 66932947;162809334

N-Term(iTRAQ4plex) 0.835 1 1.008 1 0.82 1 0.813 1 0.858 1 0.851 1 1.047 1 43 5.1 0 3 1096.083 1.7 53.23 2207.14011

YGDSGEQIAGFVK CTSA lysosomal protective protein isoform b precursor [Homo sapiens]

5476 NP_001121167 2 3 189163485 N-Term(iTRAQ4plex); K13(iTRAQ4plex)

1.118 2 17.1 0.985 2 13 1.119 2 10 1.136 2 23.2 1.102 2 11.1 1.118 2 24.4 0.984 2 1.1 42 4.05 0 2 883.38995 -2.64 31.05 1765.77263

YGFCEAADQFHVLDEVR C8G complement component C8 gamma chain precursor [Homo sapiens]

733 NP_000597 76 1 166197660 N-Term(iTRAQ4plex); C4(Methylthio)

1.005 1 0.841 1 0.835 1 0.993 1 1.014 1 1.207 1 1.215 1 35 0 3 351.19714 0.33 9.97 1051.57688

YGFIEGHVVIPR CD44 CD44 antigen isoform 8 precursor [Homo sapiens]

960 NP_001189486 12 7 321400142 N-Term(iTRAQ4plex) 1.104 2 0.1 0.864 2 7 0.956 2 1.6 1.106 2 5.4 1.103 2 4.9 1.276 2 2.1 1.154 2 3.3 34 3.83 0 2 611.31378 0.17 40.9 1221.61638

YGFYTHVFR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 4 1 4503635 N-Term(iTRAQ4plex) 1.091 1 0.771 1 0.878 1 1.138 1 1.054 1 1.366 1 1.2 1 32 0 2 619.37036 1.71 73.54 1237.73345

YGGGFYSTQDTINAIEGLTEYSLLVK

C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 34 2 38016947 N-Term(iTRAQ4plex); K26(iTRAQ4plex)

1.675 2 68.5 1.17 2 36.9 1.737 2 113 1.485 2 59.4 1.916 2 83.5 1.638 2 38.4 1.103 2 18.1 24 5.15 1 4 661.7785 -3.95 36.78 2644.09585

YGGPNHHLPLPDNWK CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 10 1 4503011 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

1.41 1 0.942 1 1.301 1 1.381 1 1.438 1 1.526 1 1.106 1 59 6.55 0 3 634.64136 -2.91 34.02 1901.90952

YGIDWASGR FCN3 ficolin-3 isoform 1 precursor [Homo sapiens]

8547 NP_003656 8 2 27754776 N-Term(iTRAQ4plex) 1.778 11 15.6 1.066 11 15.9 1.68 11 18.7 1.725 11 16 1.919 11 9.4 1.961 11 6.9 1.137 11 2.7 102 6.2 0 2 940.50323 -0.66 31.06 1879.99919

YGIYTK F9;F10 coagulation factor IX preproprotein [Homo sapiens];coagulation factor X preproprotein [Homo sapiens]

2158;2159 NP_000124;NP_000495

1 2 4503649;4503625

N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.489 16 17.5 1.041 16 26.5 1.361 16 29.6 1.472 16 23.2 1.564 16 29 1.682 16 20.5 1.097 16 12.6 96 7.9 0 3 931.13 0.23 79.53 2791.37986

YGLDSDLSCK SERPINF1 pigment epithelium-derived factor precursor [Homo sapiens]

5176 NP_002606 15 1 39725934 N-Term(iTRAQ4plex); C9(Methylthio); K10(iTRAQ4plex)

1.643 6 16.4 0.899 6 18.3 1.431 6 29.3 1.634 6 19.4 1.574 6 19.3 1.761 6 21.1 1.133 6 8.8 74 6.11 0 3 1004.475 -1.85 27.43 2007.94242

YGLVTYATYPK CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 67 1 67782358 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

4.954 4 5.4 0.849 4 23.5 3.966 4 13.6 5.055 4 37.3 4.301 4 13.4 5.694 4 34.4 1.126 4 6.6 70 5.75 0 3 1004.475 -1.85 27.43 2023.94437

YGMVAQVTQTLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 27 1 105990532 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.617 2 6.5 0.791 2 13.1 1.434 2 10.2 1.814 2 2.9 1.464 2 14.3 1.852 2 1.2 1.021 2 4.1 68 6.52 0 3 602.30988 0.65 35.92 1804.91507

YGMVAQVTQTLK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 15 1 105990532 N-Term(iTRAQ4plex); M3(Oxidation); K12(iTRAQ4plex)

1.852 2 11.5 0.947 2 1.3 1.694 2 8.1 1.788 2 9.5 1.913 2 13.3 2.019 2 14.6 1.129 2 5.1 48 3.49 0 2 605.30292 -3.11 50.56 1209.60649

YGMWTIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 33 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.796 1 0.994 1 1.69 1 1.701 1 1.889 1 1.902 1 1.118 1 43 4.85 0 3 931.13 0.23 79.53 2807.36954

YGMWTIK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 1 2 38016947 N-Term(iTRAQ4plex); M3(Oxidation); K7(iTRAQ4plex)

2.018 1 1.052 1 1.99 1 1.892 1 2.15 1 2.044 1 1.08 1 31 0 2 478.80457 0.93 32.28 956.60185

YGQPLPGYTTK IGFBP3 insulin-like growth factor-binding protein 3 isoform b precursor [Homo sapiens]

3486 NP_000589 4 2 62243068 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.012 1 0.824 1 1.66 1 2.015 1 2.01 1 2.44 1 1.211 1 3.46 1 3 833.40564 -18.28 25.46 2498.20237

YGQTIRPICLPCTEGTTR CFB complement factor B preproprotein [Homo sapiens]

629 NP_001701 40 1 67782358 N-Term(iTRAQ4plex); C9(Methylthio); C12(Methylthio)

1.253 3 0.5 1.073 3 10.2 1.265 3 15.5 1.211 3 1.3 1.292 3 1.5 1.28 3 10.9 1.085 3 7 87 6.46 0 2 931.01801 -0.71 64.26 1861.02764

YGTLFTMDR TGFBI transforming growth factor-beta-induced protein ig-h3 precursor [Homo sapiens]

7045 NP_000349 2 1 4507467 N-Term(iTRAQ4plex) 1.203 1 1.005 1 1.093 1 1.088 1 1.319 1 1.313 1 1.207 1 87 5.25 0 2 857.50061 4.18 33.54 1713.99394

YGVSHPDAGAAWR NAGLU alpha-N-acetylglucosaminidase precursor [Homo sapiens]

4669 NP_000254 2 1 66346698 N-Term(iTRAQ4plex) 1.17 4 9.6 0.941 4 15.7 1.04 4 4.2 1.112 4 6.8 1.162 4 9.7 1.308 4 18.3 1.149 4 14 74 5.74 0 3 906.45007 -4.2 20.6 1811.8945

YHFEALADTGISSEFYDNANDLLSK

C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 38 1 4557389 N-Term(iTRAQ4plex); K25(iTRAQ4plex)

1.037 1 0.804 1 0.852 1 1.059 1 1.019 1 1.268 1 1.197 1 51 3.43 0 2 647.86719 2.71 32.71 1294.7271

YHFVTPLTSMVVTKPEDNEDER

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 12 1 133925809 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

1.494 1 0.921 1 1.302 1 1.414 1 1.569 1 1.703 1 1.204 1 45 4.97 0 3 533.94067 -1.29 14.14 1599.80747

YHFVTPLTSMVVTKPEDNEDER

ITIH3 inter-alpha-trypsin inhibitor heavy chain H3 preproprotein [Homo sapiens]

3699 NP_002208 3 1 133925809 N-Term(iTRAQ4plex); M10(Oxidation); K14(iTRAQ4plex)

32 0 3 1053.2717 1.65 82.62 3157.80063

YHQDTQGWGDIGYSFVVGSDGYVYEGR

PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor [Homo sapiens]

114770 NP_443122 58 1 156616294 N-Term(iTRAQ4plex) 1.416 1 1.057 1 1.395 1 1.32 1 1.518 1 1.437 1 1.089 1 36 0 2 488.81619 -3.09 22.88 976.62511

YHWEHTGLTLR APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex) 1.215 1 0.787 1 0.889 1 1.13 1 1.281 1 1.629 1 1.441 1 41 3.55 0 3 648.69873 1.9 71.67 1944.08164

YIALDEWAGCFGIK SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 4 1 4507171 N-Term(iTRAQ4plex); C10(Methylthio); K14(iTRAQ4plex)

1.127 1 0.95 1 1.009 1 1.062 1 1.188 1 1.251 1 1.178 1 28 0 2 478.82074 -3.29 45.98 956.6342

YIFHNFMER ITIH4;ITIH4 inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens];inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]

3700;3700 NP_002209;NP_002209

6 2 31542984;262050538

N-Term(iTRAQ4plex) 0.748 1 0.848 1 0.66 1 0.778 1 0.723 1 0.853 1 1.097 1 27 0 2 584.38226 -0.83 46.21 1167.75725

YIILLLGK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 6 1 89191868 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.294 48 6.5 0.943 48 9.4 1.205 48 7.4 1.237 48 12.1 1.349 48 8.3 1.426 48 14.5 1.125 48 4.4 99 5.96 0 3 895.96313 -0.26 60.04 1790.92095

YILQGVTSWGLGCARPNKPGVYVR

PLG plasminogen isoform 1 precursor [Homo sapiens]

5340 NP_000292 9 1 4505881 N-Term(iTRAQ4plex); C13(Methylthio); K18(iTRAQ4plex)

1.171 90 9.7 0.921 90 10.9 1.072 90 11.2 1.185 90 10.3 1.175 90 11.6 1.31 90 14.7 1.111 90 9.7 93 6.78 0 3 905.94214 -0.34 28.79 1810.877

YIPPCLDSELTEFPLR SPARC SPARC precursor [Homo sapiens] 6678 NP_003109 12 1 4507171 N-Term(iTRAQ4plex); C5(Methylthio)

0.995 27 13.5 0.922 27 19.2 0.876 26 14.8 0.967 27 19.4 0.974 27 12.4 1.076 27 14.1 1.11 27 8.9 90 6.45 0 3 951.13641 6.95 77.62 2851.3826

YIPYTLYSVFNPSDHDLVLIR HGFAC hepatocyte growth factor activator preproprotein [Homo sapiens]

3083 NP_001519 4 1 4504383 N-Term(iTRAQ4plex) 1.192 1 0.856 1 0.941 1 1.099 1 1.272 1 1.485 1 1.351 1 85 6.14 0 3 972.80896 -4.19 46.69 2916.41233

YISQMK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 1 1 119392081 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.154 13 12.3 0.967 13 49.8 0.903 13 35.4 0.945 13 65.5 1.33 13 36.2 1.408 13 30.3 1.88 13 103.2 80 7.99 0 3 1235.4583 1.73 76.48 3704.3602

YIVEDTEQINREREENQGNVCK

ZNF407 zinc finger protein 407 isoform 3 [Homo sapiens]

55628 NP_001139662 1 3 226246537 N-Term(iTRAQ4plex); C21(Methylthio); K22(iTRAQ4plex)

1.538 3 4 1.126 3 13.2 1.549 3 11.6 1.57 3 14.2 1.882 3 2.1 1.574 3 4.3 1.079 3 17.7 78 5.39 0 3 876.39246 1.6 43.65 2627.17215

YIYGKPVQGVAYVR C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

11 6 178557739;67190748

N-Term(iTRAQ4plex); K5(iTRAQ4plex)

1.355 30 41.4 0.932 30 16 1.383 30 48 1.319 30 38.3 1.332 30 46.1 1.468 30 36.9 1.098 30 11 76 6.04 0 3 951.13641 6.95 77.62 2867.37467

YIYPLDSLTWIEYWPR C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 36 2 38016947 N-Term(iTRAQ4plex) 1.198 44 7.2 1.059 44 6 1.167 44 10.1 1.115 44 9.4 1.308 44 10.7 1.251 44 7.3 1.128 44 4.1 76 4.41 0 2 673.81976 -0.05 78.7 1346.63225

YKAEEHTVVLTVTGEPCHFPFQYHR

F12 coagulation factor XII precursor [Homo sapiens]

2161 NP_000496 2 1 145275213 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C17(Methylthio)

1.315 6 4.7 0.961 6 16.9 1.219 6 14.8 1.284 6 5.1 1.415 6 17.4 1.534 6 8.5 1.16 6 6.7 75 5.88 0 3 905.94214 -0.34 28.79 1826.87363

YKDGDQCETSPCQNQGK F10 coagulation factor X preproprotein [Homo sapiens]

2159 NP_000495 3 1 4503625 N-Term(iTRAQ4plex); K2(iTRAQ4plex); C7(Methylthio); C12(Methylthio); K17(iTRAQ4plex)

1.26 70 10.6 1.003 70 17.1 1.173 70 17.8 1.197 70 8.6 1.353 70 16.7 1.36 70 8.8 1.131 70 5.2 74 5.05 0 2 791.35956 -3.11 25.01 1581.71794

YKEDFSTTGTAYFEVK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 19 2 38016947 N-Term(iTRAQ4plex); K2(iTRAQ4plex); K16(iTRAQ4plex)

2.628 2 47.5 1.171 2 58.2 2.735 2 8.2 2.335 2 68.8 3.058 2 23.3 2.612 2 90 1.118 2 14.9 70 4.3 0 3 876.39246 1.6 43.65 2643.16312

YKEENDDFASFR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 21 1 4504489 N-Term(iTRAQ4plex); K2(iTRAQ4plex)

1.315 6 6.2 0.895 6 20 1.163 6 20.5 1.279 6 14.3 1.335 6 17 1.641 6 17 1.118 6 24.9 66 7.95 0 4 1415.2802 2.22 59.64 4243.82241

YKPFSQVPTGEVFYYSCEYNFVSPSK

CFHR1;CFHR2

complement factor H-related protein 1 precursor [Homo sapiens];complement factor H-related protein 2 precursor [Homo sapiens]

3078;3080 NP_002104;NP_005657

5 2 118442839;5031695

N-Term(iTRAQ4plex); K2(iTRAQ4plex); C17(Methylthio); K26(iTRAQ4plex)

1.256 45 5.6 0.921 45 9.7 1.15 45 9 1.246 45 6.2 1.293 45 9.4 1.373 45 8.7 1.138 45 4.4 64 4.62 0 2 783.87946 -2.6 39.35 1566.75163

YLDFVFAVK LAMP2 lysosome-associated membrane glycoprotein 2 isoform A precursor [Homo sapiens]

3920 NP_002285 2 3 4504957 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.204 40 14.3 0.968 40 12.3 1.114 40 11.7 1.154 40 11.6 1.247 40 16 1.283 40 12.4 1.131 40 8.2 59 5.21 0 2 901.94641 0.91 56.08 1802.88603

YLDGLTAER KRT2 keratin, type II cytoskeletal 2 epidermal [Homo sapiens]

3849 NP_000414 4 2 47132620 N-Term(iTRAQ4plex) 1.282 1 0.947 1 1.198 1 1.265 1 1.299 1 1.372 1 1.085 1 52 4.93 1 2 809.9176 -0.88 16.9 1618.82793

YLDKTEQWSTLPPETK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

2 6 178557739;67190748

N-Term(iTRAQ4plex); K4(iTRAQ4plex); K16(iTRAQ4plex)

2.08 12 10.7 0.848 12 22.5 1.874 12 23.6 2.225 12 14.4 2.015 12 17.6 2.592 12 24.6 1.158 12 15.7 51 10.41 0 5 1415.2802 2.22 59.64 4259.81123

YLDSTFTK F5 coagulation factor V precursor [Homo sapiens]

2153 NP_000121 2 1 105990535 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

0.521 3 30.6 0.8 3 29.1 1.079 3 3.5 0.884 3 1.5 0.112 3 21.3 0.14 3 52.8 0.101 3 53.6 43 8.14 0 4 1415.2802 2.22 59.64 4227.81313

YLDWIHGHIR PROC vitamin K-dependent protein C preproprotein [Homo sapiens]

5624 NP_000303 2 1 4506115 N-Term(iTRAQ4plex) 1.227 3 7.3 0.973 3 2.5 1.111 3 6.9 1.109 3 1.1 1.319 3 3.9 1.342 3 1.6 1.154 3 8 37 3.29 0 2 651.84381 -0.56 33.05 1302.68035

YLESAGAR GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 1 1 4503987 N-Term(iTRAQ4plex) 1.276 5 10.1 0.972 5 11.3 1.199 5 9.4 1.315 5 2.6 1.368 5 2.5 1.274 5 20.6 1.16 5 27.1 36 4.05 1 3 486.93292 1.38 15.81 1458.78421

YLFLNGNK LRG1 leucine-rich alpha-2-glycoprotein precursor [Homo sapiens]

116844 NP_443204 4 1 16418467 N-Term(iTRAQ4plex); K8(iTRAQ4plex)

1.025 1 1.013 1 0.013 1 0.012 1 7.47 0 8 911.2063 -12.76 39.9 7282.59945

YLGPQYVAGITNLK LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 4 2 312433998 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.219 4 17.2 0.943 4 2.5 2.117 4 14.1 2.07 4 17.3 2.373 4 17.6 2.321 4 20.2 1.113 4 4.5 109 6.31 0 2 859.45221 -1.11 34.06 1717.89702

YLGVTLSPR GP5 platelet glycoprotein V precursor [Homo sapiens]

2814 NP_004479 4 1 4758460 N-Term(iTRAQ4plex) 2.111 7 6.8 0.955 7 17.7 1.944 7 9.1 1.964 7 8.3 2.05 7 13.2 2.223 7 12.2 1.131 7 1.4 101 7.65 0 3 1102.108 2.36 51.75 2203.19968

Page 46: Supplementary Table 3...5104 NP_000615 2 1 194018472 N-Term(iTRAQ4plex) 1.309 1 0.943 1 1.225 1 1.299 1 1.319 1 1.399 1 1.077 1 3.83 0 3 946.49261 -14.25 46.17 2837.46329 AAAITSDILEALGR

YLLSLK MSH6 DNA mismatch repair protein Msh6 [Homo sapiens]

2956 NP_000170 1 1 4504191 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

2.659 3 8.5 1.005 3 19 2.536 3 9.2 2.432 3 3.8 2.358 3 9.9 2.805 3 2.4 0.93 3 0.7 100 8.68 0 3 926.47925 -0.16 59.76 2777.43033

YLPCSVLR SERPINA4 kallistatin precursor [Homo sapiens] 5267 NP_006206 3 1 21361302 N-Term(iTRAQ4plex); C4(Methylthio)

2.768 2 2.7 1.056 2 13.2 2.559 2 0.4 2.425 2 12.8 3.134 2 7.1 2.969 2 6 1.225 2 6.8 93 5.98 0 2 864.48163 8.19 35.16 1727.95598

YLQEIYNSNNQK FGG fibrinogen gamma chain isoform gamma-A precursor [Homo sapiens]

2266 NP_000500 2 2 70906437 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

0.82 1 1.019 1 0.611 1 0.6 1 1.044 1 1.024 1 1.708 1 91 8.28 0 3 1041.4465 1.24 50.27 3122.32505

YLQGSSVQLR VASN vasorin precursor [Homo sapiens] 114990 NP_612449 2 1 88702793 N-Term(iTRAQ4plex) 0.824 2 7.9 1.069 2 26 0.78 2 13.4 0.729 2 12.3 0.929 2 28.2 0.869 2 2 1.191 2 14.3 89 7.74 0 3 1148.8068 4.57 58.52 3444.38156YLSDHSFLVSQGDR VWF von Willebrand factor preproprotein

[Homo sapiens]7450 NP_000543 5 1 89191868 N-Term(iTRAQ4plex) 1.772 2 45.7 0.857 2 21.9 1.577 2 31.2 1.841 2 55.8 1.721 2 37.6 2.009 2 63.3 1.091 2 6 88 4.04 0 2 788.86456 -1.01 31.28 1576.72185

YLTLNTESTR BCHE cholinesterase precursor [Homo sapiens]

590 NP_000046 4 1 4557351 N-Term(iTRAQ4plex) 1.876 2 8.6 0.954 2 25.1 1.736 2 8.4 1.82 2 16.5 1.931 2 32.5 2.024 2 7 1.112 2 23.7 86 8.69 0 3 1049.2263 5.77 47.88 3145.6644

YMDGMTVGVVR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 4 1 34734066 N-Term(iTRAQ4plex) 2.682 3 4.6 0.817 3 16 2.376 3 9.1 2.65 3 13.9 2.652 3 3.4 2.846 3 1.7 1.116 3 5.7 84 5.12 0 2 1112.6154 -0.59 64.82 2224.22344

YMDGMTVGVVR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 3 1 34734066 N-Term(iTRAQ4plex); M2(Oxidation)

2.735 5 1.1 1.045 5 5.9 2.547 5 9.6 2.407 5 10 2.936 5 9.5 2.7 5 8.3 1.109 5 4.2 80 5.23 0 2 858.92505 -6.48 38.53 1716.85491

YMDGMTVGVVR FBLN1 fibulin-1 isoform D precursor [Homo sapiens]

2192 NP_006477 1 1 34734066 N-Term(iTRAQ4plex); M2(Oxidation); M5(Oxidation)

2.183 3 34 1.037 3 0.5 2.09 3 36.6 2.016 3 23.9 2.356 3 32.3 2.272 3 18 1.127 3 4 75 3.71 0 2 744.31335 -15.12 16.95 1487.61943

YNALDLTNNGK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 17 1 105990532 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.978 1 1.27 1 2.045 1 1.61 1 2.446 1 1.926 1 1.196 1 73 5.36 0 3 664.60486 -10.54 25 1991.80002

YNEQHVPGSPFTAR FLNA filamin-A isoform 1 [Homo sapiens] 2316 NP_001447 2 2 116063573 N-Term(iTRAQ4plex) 2.247 2 14.6 0.788 2 4.1 1.862 2 15.6 2.362 2 11.4 2.156 2 17.1 2.735 2 13 1.158 2 1.5 72 6.85 0 3 1073.5848 4.12 21.55 2146.15409

YNHDIALLELDEPLVLNSYVTPICIADK

F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 22 1 4503649 N-Term(iTRAQ4plex); C24(Methylthio); K28(iTRAQ4plex)

2.103 1 1.527 1 2.843 1 1.863 1 2.469 1 1.618 1 0.868 1 71 3.63 0 3 510.29922 -6.97 17.8 1528.88312

YNILPEKEDSPFALK PZP pregnancy zone protein precursor [Homo sapiens]

5858 NP_002855 1 1 162809334 N-Term(iTRAQ4plex); K7(iTRAQ4plex); K15(iTRAQ4plex)

3.182 2 68.2 0.855 2 26.8 2.894 2 82.1 3.386 2 47.9 3.031 2 88.4 3.547 2 52.9 1.048 2 4.2 71 5.01 0 2 822.46802 0.97 50.46 1643.92876

YNILPEKEEFPFALGVQTLPQTCDEPK

A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 14 1 66932947 N-Term(iTRAQ4plex); K7(iTRAQ4plex); C23(Methylthio); K27(iTRAQ4plex)

1.171 5 2.3 0.782 5 11.3 1.045 5 5.7 1.377 5 2 1.094 5 9.7 1.297 5 1.6 1.027 5 13.2 71 7.09 0 3 778.67694 0.79 53.84 2334.01627

YNPIPSVQLMGNGFHFLAGEPR

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 6 1 169636415 N-Term(iTRAQ4plex) 2.716 4 7.7 0.924 4 11.1 2.298 4 16.1 2.547 4 7.5 2.747 4 23.7 2.928 4 13.3 1.137 4 0.9 70 6.8 0 3 908.07391 -2.96 35.44 1815.1428

YNPIPSVQLMGNGFHFLAGEPR

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 2 1 169636415 N-Term(iTRAQ4plex); M10(Oxidation)

1.75 3 24.1 0.981 3 2.9 1.668 3 28.9 1.7 3 25.8 1.798 3 22.6 1.834 3 19.6 1.115 3 1 70 5.07 0 2 897.45758 -5.01 40.37 1793.90788

YNPVVIDFEMQPIHEVLR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 10 1 4557389 N-Term(iTRAQ4plex); M10(Oxidation)

2.385 1 0.719 1 1.927 1 2.679 1 2.173 1 3.021 1 1.128 1 68 5.95 0 3 926.47925 -0.16 59.76 2793.40976

YNPVVIDFEMQPIHEVLR C8A complement component C8 alpha chain precursor [Homo sapiens]

731 NP_000553 118 1 4557389 N-Term(iTRAQ4plex) 1.451 2 15.9 1.142 2 27.8 1.501 2 1.1 1.315 2 28.9 1.62 2 1.4 1.419 2 29.2 1.079 2 0.3 67 7.82 0 3 822.0918 -0.99 55.31 2464.2623

YNSQLLSFVR TFRC transferrin receptor protein 1 [Homo sapiens]

7037 NP_003225 2 1 189458817 N-Term(iTRAQ4plex) 2.157 3 10 0.9 3 1.7 2.029 3 1.2 2.127 3 9.8 2.185 3 10 2.29 3 18.8 1.142 3 8.8 67 4.64 0 2 827.88074 -0.02 52.24 1654.7542

YNSQNQSNNQFVLYR KNG1;KNG1 kininogen-1 isoform 2 precursor [Homo sapiens];kininogen-1 isoform 2 precursor [Homo sapiens]

3827;3827 NP_000884;NP_000884

24 3 4504893;156231037

N-Term(iTRAQ4plex) 2.422 2 32.7 1.1 2 17.2 2.513 2 36.8 2.284 2 56.7 2.564 2 10.4 2.33 2 28.1 1.02 2 25.7 66 9.04 0 4 1096.8718 4.02 44.67 3288.59047

YPIEHGIITNWDDMEK ACTG2 actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

72 NP_001606 3 4 4501889 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

2.469 3 3 0.837 3 6.8 2.203 3 1.7 2.514 3 3.1 2.398 3 1.9 2.772 3 0.8 1.103 3 2.3 66 5.12 0 2 884.4444 1.83 24.87 1767.88152

YPIEHGIITNWDDMEK ACTG2 actin, gamma-enteric smooth muscle isoform 1 precursor [Homo sapiens]

72 NP_001606 1 4 4501889 N-Term(iTRAQ4plex); M14(Oxidation); K16(iTRAQ4plex)

2.956 1 0.807 1 2.646 1 3.28 1 2.695 1 3.342 1 1.019 1 64 6.4 0 3 1102.108 2.36 51.75 2219.20035

YPLVVFSHGLGAFR PLA2G7 platelet-activating factor acetylhydrolase precursor [Homo sapiens]

7941 NP_005075 4 1 189095271 N-Term(iTRAQ4plex) 2.491 2 19.8 0.986 2 8.7 2.293 2 29.5 2.327 2 20.3 2.653 2 20 2.692 2 11.1 1.157 2 9.1 64 4.08 0 2 796.46216 -0.38 80.57 1591.91704

YPLYVLK CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 11 2 126273569 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.128 2 57.2 0.999 2 20.2 2.005 2 44 2.007 2 68.6 2.258 2 46.5 2.26 2 71.5 1.126 2 2.2 63 4.2 0 3 797.43213 -3.64 19.15 1593.85698

YPPPAVESDAADIVFLIDSSEGVRPDGFAHIR

COL6A3 collagen alpha-3(VI) chain isoform 1 precursor [Homo sapiens]

1293 NP_004360 1 3 55743098 N-Term(iTRAQ4plex) 1.308 5 14.9 0.943 5 3.6 1.25 4 5.2 1.311 4 17.5 1.23 5 11.5 1.296 5 18.6 0.995 4 10.1 62 7.79 1 3 905.50854 1.46 41.52 2714.51712

YPPTVSMVEGQGEK CFP properdin precursor [Homo sapiens] 5199 NP_001138724 10 1 223671861 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

2.657 1 1.007 1 2.495 1 2.476 1 2.84 1 2.818 1 1.138 1 62 7.3 0 3 687.67725 0.08 23.58 2061.01719

YPPTVSMVEGQGEK CFP properdin precursor [Homo sapiens] 5199 NP_001138724 1 1 223671861 N-Term(iTRAQ4plex); M7(Oxidation); K14(iTRAQ4plex)

2.823 3 20.2 0.869 3 11.1 2.447 3 28.5 2.975 3 2.8 2.654 3 19.3 3.289 3 2.6 1.125 3 3.4 62 3.34 0 2 610.91412 -0.91 64.34 1220.82097

YPSLSIHGIEGAFDEPGTK CNDP1 beta-Ala-His dipeptidase precursor [Homo sapiens]

84735 NP_116038 7 1 21071039 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

1.027 3 11.4 0.954 3 9.3 0.939 3 19.3 0.985 3 9.9 1.068 3 13.2 1.12 3 3.9 1.137 3 0.9 61 4.13 0 2 657.35309 1.4 38.65 1313.6989

YPVAHFIDQTLK SERPING1 plasma protease C1 inhibitor precursor [Homo sapiens]

710 NP_000053 17 1 73858568 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

1.093 4 8.5 0.971 4 3.2 1.036 4 6.3 1.059 4 5.2 1.142 4 9.4 1.149 4 8.1 1.125 4 4.1 60 5.35 0 2 776.41583 -1.43 49.5 1551.82439

YPVYGVQWHPEK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 2 1 4503987 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.429 3 7.5 0.995 3 16 2.382 3 1.5 2.358 3 3.7 2.531 3 2.3 2.71 3 4.2 1.121 3 7.9 60 4.73 0 2 726.91003 -4.18 34.93 1452.81096

YQAEFPMSPVTSAHAGTYR LOC100653070

PREDICTED: leukocyte immunoglobulin-like receptor subfamily A member 3-like, partial [Homo sapiens]

100653070 XP_003403896 2 9 341914912 N-Term(iTRAQ4plex) 2.432 5 16 1.032 5 25.3 2.187 5 14.9 2.276 5 15.8 2.443 5 9.2 2.454 5 20 1.117 5 5.3 59 4.17 0 2 717.91339 -2.8 49.36 1434.81999

YQCYCYGR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

7 6 47132549;16933542

N-Term(iTRAQ4plex); C3(Methylthio); C5(Methylthio)

1.661 3 1 1.043 3 2.1 1.592 3 14.9 1.618 3 10.8 1.826 3 12.6 1.885 3 13.1 1.147 3 2.3 57 4.37 1 2 842.44873 -4.57 23.15 1683.89018

YQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDK

HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 40 2 4826762 N-Term(iTRAQ4plex); C6(Methylthio); K34(iTRAQ4plex)

1.066 2 1.9 0.987 2 13.7 0.997 2 11.2 1.01 2 2.4 1.123 2 6.5 1.137 2 7.2 1.126 2 4.8 56 4.32 0 2 677.35126 -6.6 25.34 1353.69951

YQIWTTVVDWIHPDLK CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 89 1 119392081 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.445 2 120.1 1.173 2 35.7 1.314 2 57.5 1.12 2 108.3 1.824 2 115.2 1.554 2 199 1.388 2 39.9 56 5.8 0 4 941.11047 -3.4 72.33 3761.42006

YQIWTTVVDWIHPDLKR CFI complement factor I preproprotein [Homo sapiens]

3426 NP_000195 10 1 119392081 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.87 2 39.8 0.849 2 6.7 1.556 2 41.3 1.833 2 33.9 1.902 2 44.9 2.24 2 37.4 1.222 2 3.2 55 5.71 0 3 509.29266 -0.48 34.78 1525.86344

YQLAVTQR AOC3 membrane primary amine oxidase [Homo sapiens]

8639 NP_003725 1 1 4502119 N-Term(iTRAQ4plex) 1.456 1 1.078 1 1.447 1 1.342 1 1.58 1 1.465 1 1.092 1 53 3.55 0 2 801.42395 -3.14 45.22 1601.84062

YQYNTDVVFDSQGK VNN1 pantetheinase precursor [Homo sapiens]

8876 NP_004657 6 1 223633991 N-Term(iTRAQ4plex); K14(iTRAQ4plex)

0.992 1 0.839 1 0.829 1 0.987 1 0.996 1 1.187 1 1.202 1 50 7.02 0 3 713.0611 0.4 32.15 2137.16874

YRGDQDATMSILDISMMTGFAPDTDDLK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 3 1 115298678 N-Term(iTRAQ4plex); M9(Oxidation); K28(iTRAQ4plex)

2.474 2 18.4 0.83 2 16.9 2.072 2 28 2.496 2 10.7 2.462 2 24.8 2.967 2 7.7 1.188 2 3 50 3.78 0 2 659.38635 0.5 31.64 1317.76543

YRGDQDATMSILDISMMTGFAPDTDDLK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 9 1 115298678 N-Term(iTRAQ4plex); K28(iTRAQ4plex)

2.049 3 15 0.986 3 9.5 1.702 3 1.2 2.091 3 5 1.96 3 3.1 2.331 3 11.2 1.128 3 1.8 49 3.12 0 2 641.35004 -0.09 13.69 1281.6928

YSAWAESVTNLPQVIK C7 complement component C7 precursor [Homo sapiens]

730 NP_000578 22 1 45580688 N-Term(iTRAQ4plex); K16(iTRAQ4plex)

1.436 2 0.3 1.054 2 9 1.393 2 4.2 1.322 2 4.8 1.557 2 5.6 1.477 2 3.4 1.117 2 1.4 48 4.3 0 2 882.96802 2.18 36.61 1764.92876

YSDASDCHGEDSQAFCEK A2M alpha-2-macroglobulin precursor [Homo sapiens]

2 NP_000005 6 1 66932947 N-Term(iTRAQ4plex); C7(Methylthio); C16(Methylthio); K18(iTRAQ4plex)

2.389 1 0.936 1 2.266 1 2.423 1 2.359 1 2.521 1 1.041 1 48 4.53 0 2 774.88086 8.6 16.37 1548.75444

YSFCTDHTVLVQTR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

71 6 47132549;16933542

N-Term(iTRAQ4plex); C4(Methylthio)

1.025 2 8 0.92 2 1.8 0.902 2 3.9 0.98 2 5.7 1.066 2 9.8 1.159 2 11.6 1.182 2 5.8 47 6.87 0 3 726.35443 -0.88 54.62 2177.04874

YSFTIELR CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 7 1 126273569 N-Term(iTRAQ4plex) 2.94 1 1.328 1 3.26 1 2.456 1 3.583 1 2.699 1 1.099 1 45 3.43 0 2 591.80322 -0.15 12.66 1182.59917

YSHYNERDEIPHNDIALLK HABP2 hyaluronan-binding protein 2 isoform 2 [Homo sapiens]

3026 NP_001171131 1 2 295054188 N-Term(iTRAQ4plex); K19(iTRAQ4plex)

2.422 1 1.008 1 2.248 1 2.231 1 2.614 1 2.593 1 1.163 1 45 3.57 0 2 578.76361 -0.69 13.37 1156.51995

YSLTYIYTGLSK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 53 1 4502337 N-Term(iTRAQ4plex); K12(iTRAQ4plex)

2.123 1 0.82 1 1.798 1 2.194 1 2.065 1 2.52 1 1.149 1 45 2.79 0 2 506.25732 -13.06 14.56 1011.50737

YSLWFK PROZ vitamin K-dependent protein Z isoform 2 precursor [Homo sapiens]

8858 NP_003882 4 2 4506121 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.558 1 1.287 1 1.729 1 1.344 1 1.833 1 1.425 1 1.06 1 44 4.67 0 3 521.92053 -4.35 19.37 1563.74704

YSPGGTPTAIK KLKB1 plasma kallikrein preproprotein [Homo sapiens]

3818 NP_000883 4 1 78191798 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.557 2 51.7 0.947 2 3 1.451 2 50.9 1.532 2 47.4 1.581 2 55.8 1.669 2 52.1 1.089 2 4 43 4.19 0 2 662.83716 -1.34 24.56 1324.66704

YSQFINFPIYVWSSK HSP90B1 endoplasmin precursor [Homo sapiens]

7184 NP_003290 2 1 4507677 N-Term(iTRAQ4plex); K15(iTRAQ4plex)

2.157 1 0.925 1 1.957 1 2.117 1 2.194 1 2.373 1 1.121 1 42 3.27 0 2 545.3125 0.34 25.77 1089.61772

YSQPEDSLIPFFEITVPESQLTVSQFTLPK

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K30(iTRAQ4plex)

0.691 3 29.2 1.076 3 8.2 0.697 3 35.5 0.648 3 22.4 0.737 3 37 0.685 3 23.8 1.066 3 1.4 41 0 2 593.77222 3.39 26.25 1186.53716

YSSDYFQAPSDYR LGALS3BP galectin-3-binding protein precursor [Homo sapiens]

3959 NP_005558 2 1 5031863 N-Term(iTRAQ4plex) 2.212 4 4.3 0.847 4 8.8 1.889 4 6.8 2.26 4 5 2.196 4 6.8 2.628 4 4 1.163 4 1 41 3.47 0 2 623.82043 -0.86 26.96 1246.63591

YSTLLESEK CECR1 adenosine deaminase CECR1 isoform a precursor [Homo sapiens]

51816 NP_059120 2 2 29029550 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.603 1 0.942 1 1.479 1 1.57 1 1.635 1 1.735 1 1.105 1 40 3.62 0 2 678.30658 -0.16 31.79 1355.60588

YTACETAR F2 prothrombin preproprotein [Homo sapiens]

2147 NP_000497 15 1 4503635 N-Term(iTRAQ4plex); C4(Methylthio)

1.042 1 0.731 1 0.855 1 1.17 1 0.949 1 1.298 1 1.109 1 40 6.48 0 3 853.47418 0.78 42.88 2558.40799

YTCLPGYVR C4BPA C4b-binding protein alpha chain precursor [Homo sapiens]

722 NP_000706 8 1 4502503 N-Term(iTRAQ4plex); C3(Methylthio)

1.516 2 27.5 0.734 2 6.1 1.23 2 37.1 1.677 2 30.5 1.396 2 24.3 1.904 2 18 1.135 2 12 39 4.65 1 3 741.0484 1.43 14.19 2221.13065

YTCQGNSWTPPISNSLTCEK

C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 4 1 169636415 N-Term(iTRAQ4plex); C3(Methylthio); C18(Methylthio); K20(iTRAQ4plex)

2.029 2 2.3 0.935 2 4.3 1.852 2 4.3 1.98 2 0 2.075 2 4.5 2.218 2 0.2 1.12 2 0.2 39 3.45 0 3 628.36572 0.19 13.34 1255.72501

YTFELSR GC vitamin D-binding protein isoform 1 precursor [Homo sapiens]

2638 NP_000574 7 2 32483410 N-Term(iTRAQ4plex) 1.922 2 8.1 0.978 2 10.7 1.777 2 11.7 1.817 2 1 2.027 2 14.9 2.072 2 4.1 1.141 2 3.1 37 2.99 0 2 595.80975 -1.71 24.36 1190.61272

YTFVVPEDTR CDH5 cadherin-5 preproprotein [Homo sapiens]

1003 NP_001786 4 1 166362713 N-Term(iTRAQ4plex) 2.551 2 3.2 1.025 2 0.9 2.472 2 3.9 2.41 2 3 2.696 2 3.4 2.629 2 2.5 1.091 2 0.4 36 3.42 0 2 621.30988 -1.19 47.24 1241.61516

YTGNASALFILPDQDKMEEVEAMLLPETLK

SERPINA3 alpha-1-antichymotrypsin precursor [Homo sapiens]

12 NP_001076 1 1 50659080 N-Term(iTRAQ4plex); K16(iTRAQ4plex); K30(iTRAQ4plex)

2.436 1 0.932 1 2.194 1 2.356 1 2.512 1 2.696 1 1.145 1 35 3.97 0 2 727.86023 1.58 54.3 1454.71318

YTGNTYR FN1;FN1 fibronectin isoform 6 preproprotein [Homo sapiens];fibronectin isoform 6 preproprotein [Homo sapiens]

2335;2335 NP_997639;NP_997639

1 6 47132549;16933542

N-Term(iTRAQ4plex) 1.678 1 0.981 1 1.42 1 1.447 1 1.905 1 1.942 1 1.342 1 33 4.5 0 3 631.93439 0.69 36.74 1893.78861

YTHGHGSETLYLAPGGGDDWIYDLGIK

CPB2 carboxypeptidase B2 isoform a preproprotein [Homo sapiens]

1361 NP_001863 6 2 126273569 N-Term(iTRAQ4plex); K27(iTRAQ4plex)

2.066 1 1.056 1 2.116 1 2.004 1 2.131 1 2.017 1 1.007 1 33 0 2 566.72015 -4.05 18.41 1132.43303

YTIAALLSPYSYSTTAVVTNPK

TTR transthyretin precursor [Homo sapiens]

7276 NP_000362 4 1 4507725 N-Term(iTRAQ4plex); K22(iTRAQ4plex)

2.818 1 0.91 1 2.397 1 2.634 1 2.985 1 3.28 1 1.245 1 33 5.57 0 3 687.67725 0.08 23.58 2077.00302

YTLFQIFSK VWF von Willebrand factor preproprotein [Homo sapiens]

7450 NP_000543 10 1 89191868 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.609 2 12.1 0.968 2 3.6 1.52 2 6.3 1.57 2 10 1.646 2 14 1.7 2 17.7 1.083 2 7.6 33 3.25 0 2 592.8421 1.12 34.51 1184.67693

YTPEQVAMATVTALHR ALDOB fructose-bisphosphate aldolase B [Homo sapiens]

229 NP_000026 2 1 40354205 N-Term(iTRAQ4plex) 2.192 1 0.945 1 1.988 1 2.104 1 2.276 1 2.408 1 1.145 1 32 3.92 0 2 688.27905 -1.42 21.91 1375.55083

YTTEIIK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

4 1 66347875 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

2.5 1 1.036 1 2.308 1 2.227 1 2.783 1 2.686 1 1.206 1 32 3.4 0 2 608.77057 8 25.67 1216.53386

YTTTMGVNTYK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

10 1 66347875 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

2.781 2 20.4 0.666 2 49 1.201 2 269.2 1.803 2 128.7 3.022 2 6.5 4.536 2 56.9 2.516 2 300.2 32 6.51 0 4 918.08521 0.87 64.05 3669.31899

YTTTMGVNTYK C1R complement C1r subcomponent precursor [Homo sapiens]

715 NP_001724 XP_930935 XP_935774

1 1 66347875 N-Term(iTRAQ4plex); M5(Oxidation); K11(iTRAQ4plex)

1.891 1 0.928 1 1.737 1 1.871 1 1.909 1 2.057 1 1.099 1 29 0 2 621.30988 -1.19 47.24 1257.60954

YTVNQCR CP ceruloplasmin precursor [Homo sapiens]

1356 NP_000087 4 1 4557485 N-Term(iTRAQ4plex); C6(Methylthio)

1.183 1 1.19 1 1.229 1 1.033 1 1.362 1 1.145 1 1.109 1 27 3.49 0 3 643.27277 -1.89 33.33 1927.80375

YTYNYEAESSSGVPGTADSR

APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 22 1 105990532 N-Term(iTRAQ4plex) 1.056 1 0.937 1 1.071 1 1.143 1 0.975 1 1.041 1 0.911 1 24 3.36 0 2 605.20831 -3.34 43.94 1209.40935

YVGGQEHFAHLLILR ORM1 alpha-1-acid glycoprotein 1 precursor [Homo sapiens]

5004 NP_000598 6 1 167857790 N-Term(iTRAQ4plex) 2.491 1 0.925 1 2.212 1 2.391 1 2.584 1 2.793 1 1.168 1 4.95 1 3 521.97424 -1 16.7 1563.90818

YVGNMHGNEALGR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 14 1 4503011 N-Term(iTRAQ4plex) 1.961 1 0.974 1 1.785 1 1.833 1 2.085 1 2.141 1 1.168 1 3.16 0 2 495.29944 5.61 24.91 989.5916

YVGNMHGNEALGR CPN1 carboxypeptidase N catalytic chain precursor [Homo sapiens]

1369 NP_001299 3 1 4503011 N-Term(iTRAQ4plex); M5(Oxidation)

1.04 1 1.08 1 1.018 1 0.943 1 1.144 1 1.059 1 1.124 1 2.9 0 2 580.35077 -1.15 40.21 1159.69426

YVLPNFEVK C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

116 6 178557739;67190748

N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.428 1 0.972 1 1.336 1 1.374 1 1.481 1 1.523 1 1.109 1 3.73 2 3 798.73419 4.72 52.32 2394.18802

YVLSPYK C5 complement C5 preproprotein [Homo sapiens]

727 NP_001726 3 2 38016947 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.474 1 0.88 1 1.268 1 1.441 1 1.504 1 1.709 1 1.186 1 2.93 2 2 1064.6068 -3.14 36.3 2128.20635

YVMLPVADQDQCIR HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 10 2 4826762 N-Term(iTRAQ4plex); M3(Oxidation); C12(Methylthio)

1.615 1 0.997 1 1.536 1 1.54 1 1.69 1 1.694 1 1.1 1 3.49 1 3 941.83307 -8.69 43.25 2823.48465

YVMLPVADQDQCIR HP haptoglobin isoform 1 preproprotein [Homo sapiens]

3240 NP_005134 14 2 4826762 N-Term(iTRAQ4plex); C12(Methylthio)

1.001 2 1.9 0.856 2 8.1 0.867 2 8.4 1.013 2 0.3 0.992 2 3.2 1.159 2 4.9 1.144 2 5.2 74 7.64 0 3 782.33826 1.19 45.64 2345.00022

YVNWIK F9 coagulation factor IX preproprotein [Homo sapiens]

2158 NP_000124 1 1 4503649 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

1.228 1 0.84 1 1.015 1 1.209 1 1.244 1 1.481 1 1.225 1 66 3.65 0 2 676.40332 -6.05 30.06 1351.79936

YVPQLLK ART3 ecto-ADP-ribosyltransferase 3 isoform c precursor [Homo sapiens]

419 NP_001123489 1 3 194097382 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

0.964 1 1.015 1 0.914 1 0.901 1 1.028 1 1.013 1 1.124 1 66 3.12 0 2 916.50867 0.14 49.4 1832.01006

YVRPGGGFVPNFQLFEK GPX3 glutathione peroxidase 3 precursor [Homo sapiens]

2878 NP_002075 8 1 6006001 N-Term(iTRAQ4plex); K17(iTRAQ4plex)

1.342 1 0.816 1 1.099 1 1.348 1 1.337 1 1.639 1 1.216 1 61 6.24 0 3 597.32153 -0.35 47.37 1789.95005

YVSELHLTR KIT mast/stem cell growth factor receptor Kit isoform 2 precursor [Homo sapiens]

3815 NP_001087241 1 2 148005039 N-Term(iTRAQ4plex) 1.147 3 4.7 1.101 3 6.4 0.904 3 0.1 0.787 3 35 1.571 3 0.9 1.526 3 17.3 1.737 3 0.8 46 5.46 0 4 924.2088 2 69 3693.8163

YVSHFETEGPHVLLYFDSVPTSR

C4B;C4A complement C4-B preproprotein [Homo sapiens];complement C4-A isoform 1 preproprotein [Homo sapiens]

721;720 NP_001002029 NP_000583 XP_001722858;NP_009224 XP 003403837

139 6 178557739;67190748

N-Term(iTRAQ4plex) 1.168 1 1.034 1 1.09 1 1.054 1 1.286 1 1.243 1 1.18 1 45 4.61 0 3 546.28613 -0.82 44.21 1636.84385

YVYIAELLAHK PON1 serum paraoxonase/arylesterase 1 precursor [Homo sapiens]

5444 NP_000437 8 1 19923106 N-Term(iTRAQ4plex); K11(iTRAQ4plex)

1.118 2 16.3 0.964 2 10.6 1.03 2 21.5 1.069 2 10.8 1.167 2 21.7 1.211 2 10.9 1.133 2 0.2 44 3.31 0 2 611.83966 -1.97 36.67 1222.66631

YVYVADVAAK PON3 serum paraoxonase/lactonase 3 [Homo sapiens]

5446 NP_000931 2 1 29788996 N-Term(iTRAQ4plex); K10(iTRAQ4plex)

1.025 4 6.3 0.887 4 6.1 0.917 4 7.6 0.984 4 8.2 1.002 4 11.6 1.1 4 7.5 1.12 4 3.4 4.88 0 3 851.4458 -1.84 61.46 2552.32285

YWNDCEPPDSR HRG histidine-rich glycoprotein precursor [Homo sapiens]

3273 NP_000403 13 1 4504489 N-Term(iTRAQ4plex); C5(Methylthio)

1.469 1 1.686 1 1.85 1 1.097 1 2.096 1 1.243 1 1.133 1 3.8 1 4 384.98291 7.75 20.84 1536.90981

YYCFQGNQFLR HPX hemopexin precursor [Homo sapiens]

3263 NP_000604 191 1 11321561 N-Term(iTRAQ4plex); C3(Methylthio)

1.835 1 0.749 1 1.836 1 2.453 1 1.373 1 1.834 1 0.748 1 4.7 1 4 673.58417 -5.76 26.54 2691.31484

YYELEEK APOB apolipoprotein B-100 precursor [Homo sapiens]

338 NP_000375 4 1 105990532 N-Term(iTRAQ4plex); K7(iTRAQ4plex)

1.113 1 1.036 1 1.056 1 1.02 1 1.209 1 1.168 1 1.145 1 2.76 0 2 482.7804 -1.91 10.13 964.55351

YYGGGYGSTQATFMVFQALAQYQK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 207 1 115298678 N-Term(iTRAQ4plex); K24(iTRAQ4plex)

1.254 5 6.2 1.052 5 8.4 1.205 5 8.1 1.089 5 4.9 1.368 5 7 1.263 5 2.7 1.138 5 3.1 3.04 0 2 680.87744 -14.62 14.56 1360.74761

YYGGGYGSTQATFMVFQALAQYQK

C3 complement C3 precursor [Homo sapiens]

718 NP_000055 28 1 115298678 N-Term(iTRAQ4plex); M14(Oxidation); K24(iTRAQ4plex)

0.924 1 0.869 1 0.97 1 1.116 1 0.757 1 0.871 1 0.781 1 65 5.54 0 3 893.13916 2.11 60.27 2677.40293

YYGYTGAFR LTF lactotransferrin isoform 2 [Homo sapiens]

4057 NP_001186078 5 2 312433998 N-Term(iTRAQ4plex) 0.814 1 0.887 1 0.709 1 0.799 1 0.827 1 0.933 1 1.168 1 64 4.22 0 2 774.9295 0.93 35.96 1548.85173

YYIAASYVK GGH gamma-glutamyl hydrolase precursor [Homo sapiens]

8836 NP_003869 4 1 4503987 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.031 1 0.964 1 0.931 1 0.965 1 1.094 1 1.136 1 1.176 1 41 5.09 0 3 564.31122 -3.2 30.26 1690.9191

YYILRPEVMETYMYMWR MAN1A1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens]

4121 NP_005898 2 1 24497519 N-Term(iTRAQ4plex) 1.36 1 0.914 1 1.117 1 1.222 1 1.487 1 1.626 1 1.331 1 40 3.58 0 3 621.7005 -3.93 52.8 1863.08695

YYPLGEVFYPGPECER FCGBP IgGFc-binding protein precursor [Homo sapiens]

8857 NP_003881 XP_945749

2 1 154146262 N-Term(iTRAQ4plex); C14(Methylthio)

0.435 3 31.1 0.995 3 8.6 0.412 3 40 0.391 3 12.1 0.482 3 50.4 0.457 3 21.4 1.168 3 9.1 28 2.81 0 2 840.89709 -11.84 21.45 1680.79814

YYQENFCEQICSK C6 complement component C6 precursor [Homo sapiens]

729 NP_000056 21 1 169636415 N-Term(iTRAQ4plex); C7(Methylthio); C11(Methylthio); K13(iTRAQ4plex)

1.141 1 0.819 1 0.85 1 1.037 1 1.226 1 1.496 1 1.443 1 3.49 2 3 881.78943 -8.44 76.64 2643.35373

YYTAINFVATPDEQNR ATRN attractin isoform 2 preproprotein [Homo sapiens]

8455 NP_647538 2 3 21450863 N-Term(iTRAQ4plex) 1.175 1 0.915 1 1.072 1 1.171 1 1.179 1 1.288 1 1.1 1 36 5.87 0 4 451.996 2.56 27.24 1804.96218

YYTYLIMNK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 17 1 115298678 N-Term(iTRAQ4plex); K9(iTRAQ4plex)

1.184 1 0.846 1 1.102 1 1.302 1 1.083 1 1.28 1 0.983 1 32 4.74 0 3 492.33926 -3.61 33.02 1475.00324

YYTYLIMNK C3 complement C3 precursor [Homo sapiens]

718 NP_000055 1 1 115298678 N-Term(iTRAQ4plex); M7(Oxidation); K9(iTRAQ4plex)

1.335 1 1.74 1 1.576 1 0.906 1 2.082 1 1.196 1 1.321 1 3.79 2 4 873.94519 1.98 47.27 3492.75893

YYYDGK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 1 1 4502337 N-Term(iTRAQ4plex); K6(iTRAQ4plex)

46 4.63 0 3 524.59967 -12.89 17.25 1571.78446

YYYDGKDYIEFNK AZGP1 zinc-alpha-2-glycoprotein precursor [Homo sapiens]

563 NP_001176 7 1 4502337 N-Term(iTRAQ4plex); K6(iTRAQ4plex); K13(iTRAQ4plex)

46 4.04 0 3 477.93582 4.45 36.37 1431.79291

YYYVCQYCPAGNWANR CRISP3 cysteine-rich secretory protein 3 isoform 1 precursor [Homo sapiens]

10321 NP_006052 4 2 300244560 N-Term(iTRAQ4plex); C5(Methylthio); C8(Methylthio)

5.63 0 3 688.36884 2.63 61.58 2063.09195