Supplementary S1
4
Supplementary S1 A B C PSD-95 (r.u) PSD-95 (r.u) PSD-95 (r.u) PSD-95 tubulin tubul in PSD-95 tubul in A oligomers Nicotine -Btx - - - + - - + + - + + + - + - - - + - - + - + - A oligomers Nicotine - - - + - - + + - + + + + - Wortmannin BSD + A oligomers Nicotine - - - - + - + + - + - + + DHE - - - + 1.5 1.0 0.5 0 2.0 1.0 0 1.0 0.5 0 PSD-95
description
A. PSD-95. tubulin. 1.5. 1.0. PSD-95 (r.u). 0.5. 0. -. -. -. +. +. +. A b oligomers. -. -. -. +. +. +. Nicotine. -. -. -. -. +. +. a -Btx. B. PSD-95. tubulin. 2.0. PSD-95 (r.u). 1.0. 0. -. +. +. +. +. A b oligomers. -. -. +. +. +. Nicotine. -. -. - PowerPoint PPT Presentation
Transcript of Supplementary S1
Supplementary S1
A
B
C
PS
D-9
5 (
r.u
)P
SD
-95
(r.
u)
PS
D-9
5 (
r.u
)
PSD-95
tubulin
tubulin
PSD-95
tubulin
A oligomers
Nicotine
-Btx
---
+--
++-
+++
-+-
--+
- -
+
- +-
A oligomers
Nicotine---
+--
++-
+++
+-Wortmannin
BSD
+A oligomers
Nicotine---
-+-
++-
+-
++
DHE
-
--+
1.5
1.0
0.5
0
2.0
1.0
0
1.0
0.5
0
PSD-95
Supplementary S2
BA
NicotineWild typeNicotine
Wild type
ControlWild type
ControlWild type
Afibrils A+Nicotine (100 M; 24h)
b
B
Supplementary S3
A a
Supplementary S4
A
C
B
*
*
