SUPPLEMENTARY FIGURES
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SUPPLEMENTARY FIGURES
TGF-RI
TGF-RII
GAPDH
KLE Hec-1-A Hela
C.HIESC
Supp. 1
Par-4
-actin
Par-4
-actin
A.
B.SKOV-3
TGF-3TGF-2TGF-1
---
--+
-+-
+--
MCF7
TGF-3TGF-2TGF-1
---
--+
-+-
+--
SKOV-3TGF-3TGF-2TGF-1
---
--+
-+-
+--
MCF7
TGF-3TGF-2TGF-1
---
--+
-+-
+--
*** ***
*
* ***
SKOV-3 MCF7
Par-4
P-Smad2
GAPDH
Alk5 inh. - +
A
B Hiesc
E-cadherin
N-cadherin
Snail
β-actin
KLE
E-cadherin
N-cadherin
Snail
β-actin
Hec-1-A
C
Days 0 3 6
GAPDH
Snail
N-Cadherin
Vimentin
Days 0 3 6
TGF-3
Par
-4/G
AP
DH
GAPDH
Par-4
543210
D
Supp. 2
E
SKOV-3
E-cadherin
N-cadherin
Snail
β-actin
MCF7TGF-3TGF-2TGF-1
---
--+
-+-
+--
TGF-3TGF-2TGF-1
---
--+
-+-
+--
TGF-3TGF-2TGF-1
---
--+
-+-
+--
TGF-3TGF-2TGF-1
---
--+
-+-
+--
Claudin-1
β-actin
KLE SKOV-3
TG
F-
3C
ontr
ol
C N C N C N C N
Par-4
p-Smad2
Control TGF-1 TGF-2 TGF-3
GAPDH
PARP
Supp. 3
Par-4 Hoechst Merge
Cont
rol
TGF-
1TG
F-2
TGF-
3B.
C.A Empty
Par-4
E-cadherin
Myc-Par-4
Vimentin
Snail
β-actin
-+
+- Empty
Par-4
Myc-Par-4
Claudin-1
β-actin
-+
+-
SKOV-3 MCF7
TGFβTGFβ
NucleusNucleus
p110p110
p85p85
PIP3PIP3
PP
PPPTENPTEN
AktAkt
PDK1PDK1
PP
PP
Ser473Ser473
Thr308Thr308
PI3K
PI3K
PIP2PIP2
MitochondriaMitochondria
Cytochrome CCytochrome C
Apaf-1Apaf-1
BakBak BaxBax
BadBadPP BadBad
Bcl-2Bcl-2
Par-4Par-4
ApoptosisApoptosis
UbUb
Smad2/3Smad2/3
TGFR
TGFR
TGFR
TGFR
Par-4Par-4
Smad2/3Smad2/3
EMTEMT
IKKIKK
p50
p50
p65
p65
IkBIkB
p50
p50
p65
p65
IkBIkB
PP
C9C9 XIAPXIAP
C3C3
TGFβTGFβ
TGFRTGFRTGFR
TGFR
cleavagecleavage
Par-4Par-4
XIAPXIAP
Smad4Smad4
PP
PP
XIAPXIAP
Supp. 4