Supplemental Digital Content Figure 1A

A Academic/Research Program

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95% CI) 60 mo Survival

Lobectomy 1778 616 (35%) 1162 (65%) NA (99.6, NA) 73.6% (71.4%, 75.6%)Segmental Resection 130 71 (55%) 59 (45%) 74.6 (58.9, 87.4) 58.8% (49.7%, 66.9%)Wedge Resection 718 393 (55%) 325 (45%) 71.2 (64, 77) 57.4% (53.6%, 61.0%)

Supplemental Digital Content Figure 1B

B Comprehensive Community Cancer Program

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95% CI) 60 mo Survival

Lobectomy 2639 1055 (40%) 1584 (60%) 97.1 (92, 104) 69.2% (67.3%, 71.0%)Segmental Resection 129 59 (46%) 70 (54%) 85.7 (61.3, NA) 60.1% (50.7%, 68.3%)Wedge Resection 987 559 (57%) 428 (43%) 66 (59.1, 70) 52.6% (49.4%, 55.8%)

Supplemental Digital Content Figure 1C

C Non-Comprehensive Community Cancer Program

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95% CI) 60 mo Survival

Lobectomy 440 176 (40%) 264 (60%) 81.8 (73.8, NA) 64.2% (59.1%, 68.8%)Segmental Resection 27 17 (63%) 10 (37%) 64.6 (46.3, NA) 61.3% (40.0%, 77.0%)Wedge Resection 186 92 (49%) 94 (51%) 66.9 (53.8, 75.2) 54.6% (46.3%, 62.1%)

Supplemental Digital Content Figure 2A

A Tumor ≤ 1 cm

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95% CI) 60 mo Survival

Lobectomy 722 219 (30%) 503 (70%) NA (104.6, NA) 76.7% (73.3%, 79.7%)Segmental Resection 51 21 (41%) 30 (59%) 94.9 (58.9, NA) 64.1% (48.7%, 75.9%)Wedge Resection 439 208 (47%) 231 (53%) 82.9 (75.4, 89.4) 61.2% (56.3%, 65.8%)

Supplemental Digital Content Figure 2B

B Tumor 1 – 2 cm

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95% CI) 60 mo Survival

Lobectomy 4135 1628 (39%) 2507 (61%) 96.9 (93.2, 99.7) 69.3% (67.8%, 70.7%)Segmental Resection 235 126 (54%) 109 (46%) 73.5 (64.6, 79.9) 58.7% (52.0%, 64.8%)Wedge Resection 1452 836 (58%) 616 (42%) 64.4 (59.9, 68.3) 52.7% (50.0%, 55.3%)

Supplemental Digital Content Figure 3A

A Regional Lymph Nodes Examined ≤ 7

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95%

CI) 60 mo SurvivalLobectomy 2881 1126 (39%) 1755 (61%) 98.5 (92.2, 108.2) 69.1% (67.3%, 70.8%)Segmental Resection 246 125 (51%) 121 (49%) 74 (65.7, 89.3) 60.3% (53.8%, 66.3%)Wedge Resection 1739 974 (56%) 765 (44%) 66.3 (62.2, 70.2) 53.8% (51.3%, 56.2%)

Supplemental Digital Content Figure 3B

B Regional Lymph Nodes Examined > 7

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95%

CI) 60 mo SurvivalLobectomy 1976 721 (36%) 1255 (64%) 100.6 (97.1, 110) 72.3% (70.2%, 74.3%)Segmental Resection 40 22 (55%) 18 (45%) 69.5 (49.8, NA) 54.8% (37.5%, 69.1%)Wedge Resection 152 70 (46%) 82 (54%) 79.6 (69.1, 97.7) 64.4% (55.9%, 71.8%)

Supplemental Digital Content Figure 4A

A Negative Surgical Margins

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95%

CI) 60 mo SurvivalLobectomy 4783 1810 (38%) 2973 (62%) 99.7 (96.9, 105.3) 70.5% (69.1%, 71.8%)Segmental Resection 280 144 (51%) 136 (49%) 74 (65.7, 87.4) 59.6% (53.4%, 65.2%)Wedge Resection 1797 983 (55%) 814 (45%) 68.8 (64.8, 72.2) 55.2% (52.8%, 57.6%)

Supplemental Digital Content Figure 4B

B Positive Surgical Margins

Extent of Lung Resection

No. of Subject Event Censored

Median Survival (95%

CI) 60 mo SurvivalLobectomy 74 37 (50%) 37 (50%) 85.4 (62.7, 100.8) 66.1% (53.8%, 75.9%)Segmental Resection 6 3 (50%) 3 (50%) 65.1 (18, NA) 60.0% (12.6%, 88.2%)Wedge Resection 94 61 (65%) 33 (35%) 43.1 (31.5, 63.9) 43.7% (33.3%, 53.6%)