SupercriticalFluid

Extraction

100/200 Litres

25 Litres

5 LitresAdvanced Process

Robust TechnologycGMP Compliant

Spice Extracts, EssentialOils & Oleoresins

Natural Flavours &Fragrances

Herbal Medicines, Cosmetics& Nutraceuticals

Bioactive Compoundsfor Pharmaceuticals

CONCEPT TO COMMISSIONING

2

Comparison with other Conventional Extraction Technologies

Solvent Extraction

• Solvent traces present in final product

• Heavy metal content in final product based on application

• Inorganic salt content in final product

• Polar substances get dissolved with certain components of the final product thereby giving final product a different colour and flow characteristics, thereby making it not resemble the actual basic components to be extracted

• Product free of solvent traces

• Product free of heavy metal content

• Product free of inorganic salts

• Low operating temperatures and selective extraction of CO2 as a solvent ensures extracts resembling actual components

Steam Distillation

• Non-volatile Essential oils (in steam) cant be extracted

• Highly volatile oils are lost in distillation process

• Oxidation and hydrolysis possible

• Essential oils don’t resemble original components of natural product

• Complete essential oils get extracted

• Low temperature of process ensures zero loss of volatile oils

• No oxidation and hydrolysis possibility

• Product highly resemble original natural components in form, aroma and physical properties

Supercritical fluid extraction has gained prominence in the pharmaceutical, food and chemical sectors due to an increased preference for natural products over synthetic ones, stricter regulations related to toxicity levels and residual levels of solvents in consumer products, and increased concerns over quality and safety of food products.

SCF Extraction

SCF Extraction

Why use SCFE?

3

Benefits of SCFEover other solvents

Higher extraction efficiency

Food grade extraction due to non-existence of residual solvents, heavy metals, microbial contamination and polar substances in final product

No Hydrolysis, No decomposition, or destruction of temperature sensitive active ingredients

Better stability in the formulation, longer shelf life for end products

Cost efficient- as CO2 is a widely available & RECOVERABLE solvent

Higher concentration of active / desirable components in the extract

Lesser time of extraction process, LowerBatch Times

No pollution control related costs etc. There is practically no effluent generation in SCFE; hence the process is eco-friendly and pollution free

Environment friendly- As CO2 is recirculated and recycled the overall release of CO2 into the atmosphere is minimized.

Separation of various oil fractions like oleoresins, volatiles etc

Non-Flammable and non-toxic compared to other solvents like hexane and acetone

High boiling point components are extracted at relatively low temperatures

Selective extraction: Higher flexibility in controlling pressure/ temp of extraction for targeted extraction of certain components

Thermally labile compounds can be extracted with minimal damage

PTriple Point

TTriple Point TCritical

PCritical

Vapour

GaseousPhase

SupercriticalPhase

CompressibleLiquid

LiquidPhase

TriplePoint

Solid Phase

Triple Point and Critical Point

Pres

sure

Temprature

Supercritical carbon dioxide is a fluid state of carbon dioxide where it is held at or above its critical temperature and critical pressure.

Carbon dioxide behaves as a gas at ambient temperature and pressure conditions and behaves as a solid when frozen. If the temperature and pressure are increased from ambient conditions to be above the critical point for CO2, it adopts properties between that of a gas and liquid.

More specifically, it behaves as a supercritical fluid above its critical temperature 31.10 °C and critical pressure of 73.9 bar expanding to fill its container like a gas but with a density like that of a liquid.

In this state, carbon dioxide exhibits solvating properties of a liquid and the diffusivity of a gas. This makes it a powerful medium for extraction of natural oils from organic materials.

4

What isSupercritical CO2?

SFE: Supercritical Fluid Extraction of solids, is generally operated in batch mode on milled materials (or pellets, granulates), with food grade carbon dioxide as solvent. The equipment consists of two or more extractors operating above the CO2 critical pressure, and two separators where the extract and the CO2 are separated prior to the CO2 being recycled.

The supercritical CO2 extraction process consists of first raising the temperature and pressure of the carbon dioxide gas till it reaches super critical state. This is done using a high pressure pump and a heater. The organic raw material is loaded into the extractors through which the super critical CO2 passes. Based on

the components present in the raw materials, and the pressure-temperature settings, the supercritical CO2 extracts the oils from the raw materials and passes through a series of pressure regulator valves to enter the separators. The two separator pressures are controlled individually to separate the different components of the extract. Once the extracted oil is separated from the CO2 which escapes in the form of a gas, the oil is collected in collection vessels while the extract free Carbon dioxide is recycled by condensing and storing in the CO2 tank in the liquid form. This CO2 is then reused and the entire cycle is repeated for the duration of the batch.

5

ProcessDescription

CO2

Tank

Super Heater CO2 Pump

SuperChiller

CondenserBack Pressure

Regulator

Extr

acto

r 1

Extr

acto

r 2

Extr

acto

r 3

Sepa

rato

r 1

Sepa

rato

r 2

System Highlights

• Quick closures for extractors and separators not requiring any tools

• Proprietary design for application specific CO2 plunger pump

• Active back pressure regulation using servo actuated pin valves

• Extractors manufactured as per ASME guidelines, Section VIII with option of U-Stamp certification

• Complete automatic operation for production level plants and semi-automatic operation for pilot scale plant

• Hygienic design and customized layout to conform to cGMP standards for food safety

• Easy to use and easy to clean with standard CIP systems

Safety

• Coded sensors for all vessel caps to ensure fool proof closure

• Redundant sensors for monitoring system operation

• Burst discs for mechanical overload safety

Service and Support

• Dedicated service and after-sales team

• More than 28 years of experience in supporting customers across the world in wide range of process and automation equipment

Cybernetik AdvantageCybernetik has a pilot plant available for complete product trials

6

77

Food and Agro Products

• Spice Extracts: True essence of the Spices, essential oils and oleoresins

• Decaffeination of coffee and tea, Extraction of Green coffee Extracts

• Extraction of Natural Food colours from Paprika, Turmeric, Hibiscus, Annato etc

• Beer and Alcohol: Hops extraction and flavour extraction for Beer industry

• Extraction of pepper, red chillies, Turmeric, ginger etc

• Nicotine controlled Tobacco extraction for premium usage, Light Cigarettes

• Cannabis extraction for CBD/THC extraction for medical and recreational marijuana industry

• Natural Insecticides and Pesticides eg. Azadirachtin rich Neem Extract, Karanj, Nepetalactone from Catnip extract etc.

Pharmaceutical and Nutraceutical

• Products with High Bioactivity, properties in synergy with fresh Raw Material

• Obtaining Natural Antioxidants, Food Preservatives like Lutein, Beta-Carotene, Astaxanthin

• Purest ingredients for Herbal Medicines, Ayurveda

• Extraction of Bioactive compounds with minimum degradation for drug discovery

Flavours and Fragrances

• Natural flavours and fragrances for perfumes and other cosmetic industries

ApplicationAreas

Extractor Usable Volume (Litre)

Number of Extractors (Nos)

Use of Extractors (Series/Individual)

Number of Separators (Nos)

Number of BPRV (Nos)/ Type (Auto/Manual)

Max Pressure (Bar)/ Temperature (deg C)

Pump Type

CO2 Flowrate (Litre/hr)

Material Loading

Process valves (Auto/Manual)

5 Litre

5

1 or 2

Individual or Series

3

2/Auto

400 Bar/ 600 Bar/70 degC 110 degC

Plunger or Diaphragm

36

Top Loading

Manual

25 Litre

25

1 or 2 or 3

Individual or Series

3

2/Auto

400 Bar/70 degC

Plunger or Diaphragm

150

Top Loading

Auto

100 Litre

100

1 or 2 or 3

Individual or Series

3

2/Auto

400 Bar/70 degC

Plunger or Diaphragm

600

Top Loading

Auto

200 Litre

200

1 or 2 or 3

Individual or Series

3

2/Auto

400 Bar/70 degC

Plunger or Diaphragm

1200

Top Loading

Auto

Models:Sizes & Features

Additonal Options• Grinding mill • CO2 scrubber • Co-solvent pump • Automatic CIP skid

Corporate Office & Manufacturing Plant:

Gat No. 365, Urawade, Mutha Road,

Opposite Indo-German Technology Park

Pune, India - 412108

sales.automation@cybernetik.com

+91 20 6790 9600

automation.cybernetik.com