Summary of Experience Research Institute for Fragrance ... · Research Institute for Fragrance...

Anne Marie Api, Ph.D.

W: +1-201-689-8089 ext. 103

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Summary of Experience

Research Institute for Fragrance Materials Inc. (RIFM) 1984-present

Woodcliff Lake, New Jersey USA Vice President, Human Health Sciences 2006-present

RIFM, the most comprehensive source worldwide for toxicology data, literature and information on the evaluation of fragrance materials is the international scientific authority for the safe use of fragrance materials.

Combining an advanced knowledge of fragrance ingredient safety, senior leadership experience, an excellent work ethic and exceptional communication skills, I have established a quality record of managing fragrance ingredient safety at RIFM. I am committed to investigating new scientific methodologies to keep RIFM at the cutting edge of advancements in toxicology. I am also committed to education and inspiring others on current and future goals.

Responsible for the human health scientific program. Continue to maintain and oversee implementation of the RIFM Safety Assessment program with respect to all human health endpoints as well as computational toxicology.

Investigate and initiate new research and testing projects, including those that would involve development of new testing methodologies. I continue to promote and initiate new research projects that evaluate and improve test methodologies and assessment procedures to address the emerging safety challenges.

Initiated and oversee the publication of the RIFM safety assessments on the Food and Chemical Toxicology Fragrance Material Safety Assessment Center (http://fragrancematerialsafetyresource.elsevier.com). This is a partnership between RIFM and Elsevier for an open access resource center.

Initiated and continue to update an aggregate exposure model for providing a realistic exposure assessment to fragrance ingredients. I coordinate the implementation of this project with an industry core team Creme Global (www.cremeglobal.com), a well-established partner to industry in modeling exposure for cosmetics and foods, and their methodology is accepted by regulators.

Prior to the evolution to the safety assessment process was initiated in 2012, I directed the RIFM group summary and fragrance material review program and oversight of completion of safety assessments [for publication and submissions to regulatory groups].

Plan and maintain an annual human health research and test program budget of $7 million.

Direct interaction with the RIFM Expert Panel, an international panel of experts. Act as RIFM liaison to the Panel. Responsible for development of agendas, minutes, invited guests, management of all data for review and ensuring research program is presented and thoroughly reviewed by the Expert Panel.

Supervise a total of six full-time employees and three toxicologists who work off-site.

http://www.cremeglobal.com/

Anne Marie Api, Ph.D. September 2015

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Manage RIFM representation to the fragrance industry scientific committees; providing safety evaluation data.

Act as liaison for RIFM human health and safety program with external expert committees.

Scientific Director 1999-2005 Key job responsibilities and accomplishments were:

Responsible for the scientific program, which includes conduct of human health and environmental toxicity studies. Completed 5-year strategic plan.

Direct the RIFM group summary and fragrance material review program.

Plan and maintain an annual research and test program budget of $1.4 million.

Direct interaction with the RIFM Expert Panel.

Developed procedures and implement the flavor/fragrance ingredient data sheets (MSDS) program.

Supervise a team of eight full-time employees, five toxicologists who work off-site and four part-time employees.

Developed procedures and implement the flavor/fragrance ingredient data sheets (MSDS) program.

Manage the extensive database for RIFM and the Flavor and Extract Manufacturers’ Association (FEMA). Developed procedures for database; implement maintenance and ensure integration of new references. Supervise computer consultant.

Manager, Human Health & Safety 1996 - 1999 Key job responsibilities and accomplishments were:

Managed the human health and safety program.

Plan and maintain an annual research and test program budget.

Directed the continued update and improvements of the database, which was made available to Members. Transferred the database to a personal computer-based database software system; helped develop a more user-friendly system.

Supervised four full time employees and up to four part-time employees and two professionals who work off-site.

From January to June, 1998, managed the RIFM office in the absence of a RIFM President.

Completed a doctoral degree, while working.

Toxicologist 1987 – 1996 Key job responsibilities and accomplishments were:

Coordinated and managed human health and safety studies of fragrance ingredients.

Interact with experts to achieve the functional excellence of the test program.

Organized data entry and maintenance of the database

Developed, refined and implemented the document retrieval system.

Planned the annual testing budget.

Supervised two full time employees and up to four part-time employees and two professionals who work off-site.

Scientific Assistant 1984 - 1987 Key job responsibilities and accomplishments were:


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Outsource studies with CRO’s and managed interactions.

Active role in developing the newly formed RIFM database.

Developed guidelines for data entry.

Lever Research Inc., Safety Assurance Section 1980-1984

Edgewater, New Jersey, USA

Senior Research Biologist 1982-1984 Key job responsibilities and accomplishments were:

Supervised animal sensitization and rabbit eye tests. Supervise activities of technician and graduate.

Prepared perfume safety clearance reports and developed labels for Industrial Products.

Metabolism work in rats. Used radiolabeled material to determine excretion pattern.

Responsible for initial screening and dissemination of toxicology work requisitions.

Created and established, an on-line system for storage and retrieval of all requisitions and formulations received.

Prepare and issue Standard Operating Procedures in accordance with GLP regulations.

Research Biologist 1980-1982 Key job responsibilities and accomplishments were:

Assisted in planning and monitoring human sensitization studies.

Prepared Material Safety Data Sheets for raw materials as well as finished products. Responsible for creating new MSDS forms. Devised and implemented retrieval system for raw material data files.

Performed clinical hematology tests in subacute studies. Assisted computer programmers in adopting software package to interface with hematology instrument.

Certified prosector for necropsy procedure.


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Education Ph.D., Aston University, Birmingham England, 1996. Graduate degrees were achieved while maintaining a full-time position. M.S. Toxicology, St. John's University, Jamaica, New York, USA 1983. Graduate degrees were achieved while maintaining a full-time position. B.S. Biochemistry, cum laude, Manhattan College, Riverdale, New York, USA, 1980.

Professional organizations American Academy of Dermatology

American Chemical Society,

American Contact Dermatitis Society,

American Management Association

American Society for Photobiology,

Dermal Clinical Evaluation Society (Board of Director 1991-1997),

European Society Contact Dermatitis

Society of Investigative Dermatology

Society of Toxicology

Dermal Toxicology Specialty Section Secretary/Treasurer 2006-2008

Society of Toxicology Mid-Atlantic Chapter,

Women in Flavor & Fragrance Commerce Board of Director (1997-2015; Treasurer 2008-present)

University Appointments

Adjunct Assistant Professor, University of Medicine and Dentistry of New Jersey, School of Health Related Professions, Departments of Clinical Laboratory Sciences, Newark, NJ (2004- 2008).

Peer Review Panels 1. Dr. Api has served on the independent scientific peer review panel organized by the

National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) in collaboration with the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) to review the validation status of several recent modifications to the Murine Local Lymph Node Assay (LLNA), March 4-7, 2008.

Continuing Education Courses 1. American Management Association seminar on October 19-21, 1998 - Managing

Technical Professionals (Meeting 02285-119); 1.8 CEUs awarded


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2. American Management Association seminar on June 18, 1999 - Handling People With Diplomacy and Tact (Meeting KBT9039); 0.6 CEUs awarded

3. American Management Association On-Site Seminar, May 7-8, 2003 - Effective Presentation Skills for Technical Professionals, 1.2 CEUs awarded

4. American Management Association Seminar, December 16-17, 2004 – Confronting the Tough Stuff: Turning Managerial Challenges into Positive Results, 1.2 CEUs awarded

5. American Management Association Seminar, July 11-13, 2005 – Fundamentals of Finance and Accounting for Nonfinancial Managers, 1.8 CEUs awarded

6. American Management Association Seminar, March 19-21, 2007 – The Essentials of Budgeting: From Creation through Application, 1.8 CEUs awarded

7. American Society Contact Dermatitis, July 2001 - 6th Contact Dermatitis State-of-the-Art

Conference, 0.9 CEUs awarded.

8. American Society Contact Dermatitis, July, 2003 - 7th Contact Dermatitis State-of-the-Art

Conference, 0.9 CEUs awarded.

9. American Society Contact Dermatitis, July 7-9, 2005 - 8th Contact Dermatitis State-of-the-

Art Conference, 0.9 CEUs awarded.

10. Society of Toxicology 30th Annual Meeting, Continuing Education Course #5 and # 12,

Risk Communication: Problems, Perceptions and Practice, February 25, 1991

11. Society of Toxicology 31st Annual Meeting, Continuing Education Course AM#2 or PM #7,

Case Studies in Risk Assessment: Emphasis on Exposure, February 23, 1992

12. Society of Toxicology 32nd

Annual Meeting, Continuing Education Course AM#4, Coping with Nongenotoxic Carcinogens: Mode of Action, Detection and Risk Assessment, March 14, 1993


Annual Meeting, Continuing Education Course PM#9, Immunology of Chemical Hypersensitivity, March 14, 1993

14. Society of Toxicology 33rd Annual Meeting, Continuing Education Course AM#4,

International Harmonization: Update on Scientific and Regulatory Issues, Part I: Foods, Drugs, Cosmetics, and Devices, March 13, 1994

15. Society of Toxicology 33rd Annual Meeting, Continuing Education Course PM#10,

International Harmonization: Update on Scientific and Regulatory Issues, Part II: Foods, Drugs, Cosmetics, and Devices, March 13, 1994

16. Society of Toxicology 35th Annual Meeting, Continuing Education Course AM#7, Aquatic

Toxicology and Human Health Risk Assessments: Shared Metabolic Pathways, Shared Mechanisms of Action, Plus Data at the Bottom of the Dose Response Curve, March 10, 1996

17. Society of Toxicology 35th Annual Meeting, Continuing Education Course PM#9,

Apoptosis: Recent Advances n Detection and Regulation, March 10, 1996

18. Society of Toxicology 36th Annual Meeting, Continuing Education Course AM#2,

Endocrine Control of Reproductive Development - Normal and Abnormal Aspects, March 9, 1997

19. Society of Toxicology 36th Annual Meeting, Continuing Education Course PM#11, Methods

for Assessing Chemical Interaction with Steroid Receptors, March 9, 1997

20. Society of Toxicology 37th Annual Meeting, Continuing Education Course PM#12, In Vitro

and In Vivo Assessment of Cutaneous Toxicity, March 1, 1998


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21. Society of Toxicology 38th Annual Meeting, Continuing Education Course AM#6, Chemical

Hypersensitivity, March 14, 1999

22. Society of Toxicology 38th Annual Meeting, Continuing Education Course PM#10, The

Practice of Structure Activity Relationships (SAR) in Toxicology, March 14, 1999

23. Society of Toxicology 39th Annual Meeting, Continuing Education Course AM#10, Tips for

Effective Risk Communication, March 19, 2000

24. Society of Toxicology 40th Annual Meeting, Continuing Education Course AM#7,

Nutraceuticals/Functional Foods-Safety and Regulatory Issues, March 25, 2001

25. Society of Toxicology 40th Annual Meeting, Continuing Education Course PM#12, Food

Allergy and Intolerance, March 25, 2001

26. Society of Toxicology 41st Annual Meeting, Continuing Education Course AM#8,

Incorporation of Pharmacokinetic and Pharmacodynamic Data into Risk Assessments, March 17, 2002

27. Society of Toxicology 41st Annual Meeting, Continuing Education Course PM#9,

Toxicology of Naturally Occurring Toxins-Don’t Mess with Mother Nature!, March 17, 2002


Annual Meeting, Continuing Education Course PM#9, Integrating Toxicologic Pathology into Compound Evaluation and Risk Assessment II, March 9, 2003

29. Society of Toxicology 43rd Annual Meeting, Continuing Education Course AM#6,

Understanding Lifespan Changes in Form and Function of the Female Reproductive System to Assess and Interpret Toxicity, March 21, 2004

30. Society of Toxicology 43rd Annual Meeting, Continuing Education Course PM#9, Skin

Sensitization and Allergic Contact Dermatitis, March 21, 2004


Phototoxicity: Current Concepts, Experimental Designs, and Regulatory Expectations, March 6, 2005


Reproductive Toxicity Testing: Study Designs, Evaluation, Interpretation and Risk Assessment, March 5, 2006


Toxicological Evaluation of Chemical and Drug Mixtures , March 25, 2007.


Nanotoxicology: The Science of Developing a Safe Technology, March 16, 2008.

Education Seminars

1. Seminar “Dermal Sensitization Quantitative Risk Assessment (QRA) For Fragrance Ingredients”, Fairleigh Dickinson University, October 10, 2014.

2. Seminar “Dermal Sensitization Quantitative Risk Assessment (QRA) For Fragrance Ingredients”,Fairleigh Dickinson University. December 11, 2012.

3. Seminar “Dermal Sensitization Quantitative Risk Assessment (QRA) For Fragrance Ingredients”,Fairleigh Dickinson University, October 28, 2010.


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4. Seminar “Safety Evaluations Of Fragrance Materials – Grouping Structurally Related Materials”, UMDNJ Toxicology Seminar, course number TOXC4380, March 15, 2004.

5. Seminar “Safety Evaluations Of Fragrance Materials – Grouping Structurally Related Materials”, UMDNJ Toxicology Seminar, course number TOXC4380, February 24, 2003.

6. Seminar “RIFM Scientific Program Update”, UMDNJ Toxicology Seminar, course number TOXC4380, April 22, 2002.


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Publications 1. A.M. Api (2014). Research Institute for Fragrance Materials (RIFM). In: Wexler, P. (Ed.),

Encyclopedia of Toxicology, 3rd edition vol 4. Elsevier Inc., Academic Press, pp. 93–93.

2. A.M. Api (2008). The use of human data when conducting dermal sensitization quantitative risk assessments for fragrance ingredients. Regulatory Toxicology and Pharmacology, 50(2): 163-165.

3. A.M. Api (2006). Only Peru Balsam extracts or distillates are used in perfumery. Contact Dermatitis. 54(3):179.

4. A.M. Api (2005). Research Institute for Fragrance Materials (RIFM). In Encyclopedia of Toxicology (2

nd Edition). Edited by Philip Wexler, Elsevier, Oxford, pages 563-564

5. A.M. Api (2004). Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat. Food and Chemical Toxicology, 42(2):307-311.

6. A.M. Api (2002). Sensitization methodology and primary prevention of the Research Institute for Fragrance Materials. Dermatology, 205: 84-87.

7. A.M. Api (editor) (2002). Fragrance Allergy Workshop, EADV Congress Geneva October 12, 2000. Dermatology, 205:81-102.

8. A.M. Api (2001). Lack of effect of coumarin on the formation of micronuclei in an in vivo mouse micronucleus assay. Food and Chemical Toxicology, 39(8): 837-841.

9. A.M. Api (2001). Toxicological profile of diethyl phthalate: A vehicle for fragrance and cosmetic ingredients. Food and Chemical Toxicology, 39(2): 97-108.

10. A.M. Api, (1997). In vitro assessment of phototoxicity. In Vitro Toxicology, 10(3):339-350.

11. A.M. Api (1996). Development of Test Methodology for Risk Evaluation in Phototoxicity. Doctoral thesis.

12. A.M. Api, D.A. Basketter, P.A. Cadby, M.-F. Cano, G. Ellis, G.F. Gerberick, P. Greim, P.M. McNamee, C.A. Ryan, and R. Safford (2007). Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients. Regulatory Toxicology and Pharmacology, 52(1): 3-23.

13. Api, A.M., Basketter, D.A., Lalko, J.F. (2014). Correlation between experimental human and murine skin sensitization induction thresholds (2014). Cutaneous and Ocular Toxicology, DOI: 10.3109/15569527.2014.979425.

14. Api A.M., Belsito D., Bruze M., Cadby P., Calow P., Dagli M. L., Dekant W., Dent M., Ellis G., Fryer A. D., Fukayama M., Griem P., Hickey C., Kromidas L., Lalko J., Liebler D.C., Miyachi Y., Politano V.T., Renskers K., Ritacco G., Salvito D., Schultz T.W., Sipes I. G., Smith B., Vitale D., Wilcox D.K. (2015). Food and Chemical Toxicology, 82(Supplement): S1-S19. DOI information: 10.1016/j.fct.2014.11.014.

15. A.M. Api, D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, P.M. McNamee, A.E. Rogers, J.-H. Saurat, I.G. Sipes and H. Tagami (2010). Quantitative Risk Assessment of contact Sensitization: Clinical Data to assess utility of the model. Dermatitis, 21(4): 207-213.

16. A.M. Api, A. Bredbenner, M. McGowen, D. Niemiera, L. Parker, K. Renskers, S. Selim, R. Sgaramella, R. Signorelli, S. Tedrow and W. Troy, (2007). Skin contact transfer of three fragrance residues from candles to human hands. Regulatory Toxicology and Pharmacology, 48(3): 279-283.


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17. A.M. Api and R.A. Ford (2003). Evaluation of the dermal subchronic toxicity of diphenyl ether in the rat. Food and Chemical Toxicology, 41(2): 259-264.

18. A.M. Api and R.A. Ford (1999). Evaluation of the oral subchronic toxicity of HHCB

(1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta--2-benzopyran) in the rat. Toxicology Letters, 111(1-2):143-149.

19. A.M. Api, R.A. Ford and R.H.C. San (1995). An evaluation of musk xylene in a battery of genotoxicity tests. Food and Chemical Toxicology, 33(12): 1039-1045.

20. A.M. Api and R. Gudi (2000). An in vivo mouse micronucleus assay on musk ketone. Mutation Research, 464: 263-267.

21. A.M. Api and P.J. Hakkinen (2005). Fragrances and Perfumes. In Encyclopedia of Toxicology (2

nd Edition). Edited by Philip Wexler, Elsevier, Oxford, pages 382-384.

22. A.M. Api, A. Lapczynski, D.A. Isola and I.G.Sipes (2007). In vitro penetration and subchronic toxicity of alpha-methyl 1,3-benzodioxole-5-propionzaldehyde. Food and Chemical Toxicology, 45(5):702-707.

23. A.M. Api, E.M. Lewis, A.M. Hoberman, J.S. Christian and R.M. Diener (2006). Evaluation of the developmental toxicity of α-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde in rats International Journal of Toxicology, 25:127-132.

24. A.M.Api, G. Ritacco, and D.R. Hawkins (2013). The fate of dermally applied [(14)C]d-limonene in rats and humans. International Journal of Toxicology (formerly Journal of the American College of Toxicology), 32(2), 130-135.

25. A.M.Api, G. Ritacco, and I.G. Sipes (2013). Disposition and excretion of (14)C-AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl- 1,2,3,4-tetrahydronaphthalene) and (14)C-HHCB (1,3,4,6,7,8-hexahydro- 4,6,6,7,8,8-hexamethyl-cyclopenta- gamma-2-benzopyran) after intravenous administration to Sprague-Dawley rats and domestic pigs. International Journal of Toxicology (formerly Journal of the American College of Toxicology), 32(4), 288-295.

26. A.M. Api, E.A. Pfitzer and R.H.C. San (1996). An evaluation of genotoxicity tests with musk ketone. Food and Chemical Toxicology, 34(7):633-638.

27. A.M. Api, G. Ritacco, and D.R. Hawkins (2013). The fate of dermally applied [14C]d-limonene in rats and humans International. Journal of Toxicology, 32 (2): 130-135.

28. A.M. Api, G. Ritacco and I.G. Sipes (2013). Disposition and excretion of 14C-AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) and 14C-HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran) after intravenous administration to female Sprague Dawley rats and domestic pigs. International Journal of Toxicology, 32 (4): 288-295.

29. A.M. Api and R.H.C. San (1999). Genotoxicity tests with 6-acetyl-1,1,2,4,4,7-

hexamethyltetraline and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclo-penta--2-benzopyran. Mutation Research, 446: 667-681.

30. A.M. Api, R.L. Smith, S. Pipino, T.Marczylo and F. DeMatteis (2003). Evaluation of the oral subchronic toxicity of AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) in the rat. Food and Chemical Toxicology, 42, 791-801.

31. A.M. Api and M. Vey (2011). Regulatory and Safety Aspects of Natural Fragrance Ingredients. In Formulating, Packaging and Marketing of Natural Cosmetic Products. Edited by N Dayan and L Kromidas, John Wiley & Sons, Inc.


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32. A.M. Api and M. Vey (2010). A new IFRA Standard on the fragrance ingredient, hydroxyisohexyl 3-cyclohexene carboxaldehyde. Contact Dermatitis 62(4):254-5. doi: 10.1111/j.1600-0536.2010.01701.x.

33. A. M. Api and M. Vey (2008). Introduction, Special Issue on QRA. Regulatory Toxicology and Pharmacology, 52(1):1-2.

34. A. M. Api and M. Vey (2008). Implementation of the Dermal Sensitization QRA Method for Fragrance Ingredients. Regulatory Toxicology and Pharmacology, 52(1):53-61.

35. A.M. Api and M. Vey (2007). The Continued Implementation of the Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients. Perfumer & Flavorist

News, March 30, 2007. http://www.perfumerflavorist.com/news/6789072.html.

36. C.J. Betts, L. Beresford, R.J. Dearman, J. Lalko, A.M. Api and I. Kimber (2007). The use of ethanol:diethylphthalate as a vehicle for the local lymph node assay. Contact Dermatitis, 56: 70-75.

37. C.J. Betts, R.J. Dearman, I. Kimber, C.A. Ryan, G.F. Gerberick, J. Lalko and A.M. Api (2007). B220 analysis with the local lymph node assay: proposal for a more flexible prediction model. Journal Applied Toxicology, 27: 506-510.

38. S.P. Bhatia, V.T. Politano and A.M. Api (2013). Evaluation of genotoxicity of nitrile fragrance ingredients using in vitro and in vivo assays. Food and Chemical Toxicology, 59:784-792.

39. K.R. Brain, D.M. Green, J. Lalko and A.M. Api (2007). In-vitro human skin penetration of the fragrance material geranyl nitrile. Toxicology In Vitro, 21(1), 133-138.

40. S.L. Born, A.M. Api, R.A. Ford, F.R. Lefever and D.R. Hawkins (2003) Comparative metabolism and kinetics of coumarin in mice and rats. Food and Chemical Toxicology, 41(2): 247-258.

41. M.S. Christian, R.M. Parker, A.M. Hoberman, R.M. Diener and A.M. Api (1999). Developmental toxicity studies of four fragrances in rats. Toxicology Letters, 111(1-2): 169-174.

42. D. Comiskey, A.M. Api, C. Barratt, E.J. Daly, G. Ellis, C. McNamara, C. O'Mahony, S.H. Robison, B. Safford, B. Smith, S. Tozer (2015). Novel database for exposure to fragrance ingredients in cosmetics and personal care products. Regul Toxicol Pharmacol. 2015 Aug;72(3):660-72. doi: 10.1016/j.yrtph.2015.05.012. Epub 2015 May 19. PMID: 26003515

43. R.M. Diener, M.S. Christian, R.A. Ford, D.R. Hawkins, A. Palmer and A.M. Api (2008). Developmental toxicity safety assessment for 2-phenylethyl alcohol (PEA). In preparation.

44. R.A. Ford, A.M. Api and C.S. Letizia (1992). Monographs on fragrance raw materials. Special Issue VIII. Food and Chemical Toxicology, 30(Suppl.): 1S-137S.

45. R.A. Ford, A.M. Api and C.S. Letizia (1988). Monographs on fragrance raw materials. Special Issue VII. Food and Chemical Toxicology, 26(4): 273-415.

46. R.A. Ford, A.M. Api and P.M. Newberne (1990). 90-Day dermal toxicity study and neurotoxicity evaluation of nitromusks in the albino rat. Food and Chemical Toxicology, 28(1): 55-61.

47. R.A. Ford, A.M. Api and R.R. Suskind (1988). Allergic contact sensitization potential of hydroxycitronellal in humans. Food and Chemical Toxicology, 26(11/12): 921-926.

http://www.perfumerflavorist.com/news/6789072.html


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48. R.A. Ford, D.R. Hawkins, B.C. Mayo and A.M. Api (2001). The in vivo dermal absorption and metabolism of [4-

14C]coumarin by rats and by human volunteers under simulated

conditions of use in fragrances. Food and Chemical Toxicology, 39(2): 153-162.

49. R.A. Ford, D.R. Hawkins, R. Schwarzenbach and A.M. Api (1999). The systemic exposure to the polycyclic musks, AHTN and HHCB, under conditions of use as fragrance ingredients: evidence of lack of complete absorption from a skin reservoir. Toxicology Letters, 111 (1-2): 133-142.

50. J.M. Hanifin, A.M. Api and D.R. Bickers (2003). Considerations fro testing irritancy, allergy, and photoreactivity in fragrance safety evaluations. American Journal of Contact Dermatitis, 14 (2): 100-103.

51. D.R. Hawkins, L.F. Elsom, D. Kirkpatrick, R.A. Ford and A.M. Api (2002). Dermal absorption and disposition of musk ambrette, musk ketone and musk xylene in human subjects. Toxicology Letters, 131: 147-151.

52. R.A. Kemper, D.L. Nabb, S.A. Gannon, T.A. Snow and A.M. Api (2006). Comparative metabolism of geranyl nitrile and citronellyl nitrile in mouse, rat, and human hepatocytes. Drug Metabolism and Disposition, 34(6):1019-1029.

53. I. Kimber, R.J. Dearman, D.A. Basketter, C.A. Ryan, G.F. Gerberick, P.M. McNamee, J. Lalko, A.M. Api (2008). Dose metrics in the acquisition of skin sensitization: thresholds and importance of dose per unit area. Regulatory Toxicology and Pharmacology, 52(1):39-45.

54. J. Lalko and A.M. Api (2008). Citral: identifying a threshold for induction of dermal sensitization. Regulatory Toxicology and Pharmacology, 52(1):62-73.

55. J. Lalko and A.M. Api (2006). Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay. Food and Chemical Toxicology, 44: 739-746.

56. J.F. Lalko, R.J.Dearman, G.F.Gerberick, J.A.Troutman, A.M. Api, and I. Kimber (2013). Reactivity of chemical respiratory allergens in the peroxidase peptide reactivity assay. Toxicology In Vitro 27(2): 651-661.

57. J. Lalko, D. Isola and A.M. Api (2004). Ethanol and diethyl phthalate: vehicle effects in the local lymph node assay. International Journal of Toxicology, 23:171-177.

58. J.F. Lalko, I. Kimber, R.J. Dearman, A.M. Api and G.F. Gerberick (2013). The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions. Journal of Immunotoxicology 10(3): 292-301.

59. J.F. Lalko, I. Kimber, R.J. Dearman, G.F. Gerberick, K. Sarlo, A.M. Api (2011). Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens. Toxicology In Vitro 25: 433-445.

60. J.F. Lalko, I. Kimber, G.F. Gerberick, L.M. Foertsch, A.M. Api, and R.J. Dearman (2012). The direct peptide reactivity assay: selectivity of chemical respiratory allergens. Toxicological sciences: an official journal of the Society of Toxicology 129: 421-431.

61. A. Lapczynski, D.A. Isola, M.S. Christian, R.M. Diener and A.M. Api (2006). Evaluation of the developmental toxicity of acetyl cedrene. International Journal of Toxicology, 25(5), 423-428.

62. L.J. Loretz, A.M. Api, L. Babcock, L.M. Barraj, J. Burdick, K.C. Cater, G. Jarrett, S. Mann, Y.H. L. Pan, T.A. Re, K.J. Renskers, and C.G. Scrafford (2008). Exposure data for cosmetic products: facial cleanser, hair conditioner and eye shadow. Food and Chemical Toxicology, 46:1516-1524.


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63. L.J. Loretz, A.M. Api, L. Barraj, J. Burdick, D.A. Davis, W. Dressler, E. Gilberti, G. Jarret, S. Mann, Y.H.L. Pan, T. Re, K. Renskers, C. Scrafford and S. Vater (2006). Exposure data for personal care products: Hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant. Food and Chemical Toxicology, 44: 2008-2018.

64. L.J. Loretz, A.M. Api, L.M. Barraj, J. Burdick, W.E. Dressler, S.D. Gettings, H. Han Hsu, Y.H. L. Pan, T.A. Re, K.J. Renskers, A. Rothenstein and C. Sewall (2005). Exposure data for cosmetic products: lipstick, body lotion, and face cream. Food and Chemical Toxicology, 43:279-291.

65. S.E. Loveless, A.-M. Api, R.W.R. Crevel, E. Debruyne, A. Gamer, I.R. Jowsey, P. Kern, I. Kimber, L. Lea, P. Lloyd, Z. Mehmood, W. Steiling, G. Veenstra, M. Woolhiser and C. Hennes (2009). Potency Values from the Local Lymph Node Assay: Application to Classification, Labelling and Risk Assessment. Regulatory Toxicology and Pharmacology, accepted for publication Regulatory Toxicology and Pharmacology, 56(1):54-66.

66. P.M. McNamee, A.M. Api, D.A. Basketter, G.F. Gerberick, D.A. Gilpin, B.M. Hall, I. Jowsey and M.K. Robinson (2008). A review of critical factors in the conduct and interpretation of the human repeat insult patch test. Regulatory Toxicology and Pharmacology, 52(1):24-34.

67. M. Peiser, T. Tralau, J. Heidler, A. M. Api, J. H. E. Arts, D. A. Basketter, J. English, T. L. Diepgen, R. C. Fuhl, brigge, A. A. Gaspari, J. D. Johansen, A. T. Karlberg, I. Kimber, J. P. Lepoittevin, M. Liebsch, H. I. Maibach • S. F. Martin, H. F. Merk, T. Platzek, T. Rustemeyer, A. Schnuch, R. J. Vandebriel, I. R. White and A. Luch (2012). Allergic contact dermatitis: epidemiology, molecular mechanisms in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany. Cellular and Molecular Life Sciences, 69(5): 763-781.

68. S. Pipino, A.M. Api, N. Pons, R.L. Smith and F. DeMatteis (2003). Chromogenic derivatives of AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydro-naphthalene) react with amino acids and protein in vitro. Spectral characteristics of the color products. Food and Chemical Toxicology, 42, 785-790.

69. V.T. Politano and A.M. Api (2007). The Research Institute for Fragrance Materials’ Human Repeated Insult Patch Test Protocol. Regulatory Toxicology and Pharmacology, 52(1):35-38.

70. V. Politano, R. Diener, M. Christian, A. Hoberman, A. Palmer, G. Ritacco, T. Adams and A.M. Api (2013). Oral and dermal developmental toxicity studies of phenylethyl alcohol (PEA) in rats. International Journal of Toxicology, 32(1): 32-38.

71. V.Politano, R. Diener, M.Christian, G. Ritacco and A.M. Api (2013). The pharmacokinetics of phenylethyl alcohol (PEA): safety evaluation comparisons in rats, rabbits and humans. International Journal of Toxicology, 32 (1): 39-47.

72. V.Politano, R. Diener, M.Christian, G. Ritacco and A.M. Api (2013). The pharmacokinetics of phenylethyl alcohol (PEA): safety evaluation comparisons in rats, rabbits and humans. International Journal of Toxicology, 32 (1): 39-47.

73. V.T. Politano, D.A. Isola, J. Lalko and A.M. Api (2006). The effects of vehicles on the human dermal irritation potentials of allyl esters. International Journal of Toxicology, 25(3):183-193.

74. V.T. Politano, A.A. Lapczynski, G. Ritacco, A.M. Api (2012). Ninety-day toxicity study of alpha-iso-methylionone in rats. International journal of toxicology 31: 595-601.


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75. V.T. Politano, C.S. Letizia, M.S. Christian, R.M. Diener and A.M. Api (2009). Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl) ethanone (OTNE) in rats. International Journal of Toxicology, 28(3):213-218.

76. V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener and A.M. Api (2009). Evaluation of the developmental toxicity of dihydromyrcenol in rats. Int J Toxicol. 28(2):80-7. doi: 10.1177/109158180933389

77. V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener and A.M. Api (2008). Evaluation of the developmental toxicity of linalool in rats. International Journal of Toxicology, 27(2):183-188.

78. V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener and A.M. Api (2008). Evaluation of the developmental toxicity of methyl dihydrojasmonate (MDJ) in rats. International Journal of Toxicology, 27(3):295-300.

79. V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener and A.M. Api (2007). Evaluation of the developmental toxicity of α-iso-methylionone rats. International Journal of Toxicology, 26:271-276.

80. V.T. Politano, D. McGinty, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M Diener, and A.M. Api. (2013). Uterotrophic Assay of Percutaneous Lavender Oil in Immature Female Rats. International Journal of Toxicology, 32(2): 123-129.

81. V.T. Politano, D. McGinty, E.M. Lewis, A.M. Hoberman, R.M. Diener and A.M. Api (2012). Evaluation of the developmental toxicity of 4-tert-butylcyclohexyl acetate in Sprague-Dawley rats. International journal of toxicology 31: 477-482.

82. J. Potter, R.L. Smith and A.M. Api (2000). Urinary thiocyanate levels as a biomarker for the generation of inorganic cyanide from benzyl cyanide in the rat. Food and Chemical Toxicology, 39(2): 141-146.

83. J. Potter, R.L. Smith and A.M. Api (2000). An assessment of the release of inorganic cyanide from the fragrance materials, benzyl cyanide, geranyl nitrile and citronellyl nitrile applied dermally to the rat. Food and Chemical Toxicology, 39(2): 147-151.

84. D.W. Roberts, R.J. Safford, J. Lalko and A.M. Api (2015). Principles for identification of High Potency Chemicals for which the Dermal Sensitisation (DST) approach should not be applied. Regul Toxicol Pharmacol. 2015 Aug;72(3):683-93. doi: 10.1016/j.yrtph.2015.03.001. Epub 2015 Mar 9.PMID: 25765509

85. C. Rovida, N. Alépée, A.M. Api, D.A. Basketter, F.Y. Bois, F. Caloni, E. Corsini, M. Daneshian, C. Eskes, J. Ezendam, H. Fuchs, P. Hayden, C. Hegele-Hartung, S. Hoffmann, B. Hubesch, M.N. Jacobs, J. Jaworska, A. Kleensang, N. Kleinstreuer, J. Lalko, R. Landsiedel, F. Lebreux, T. Luechtefeld, M. Locatelli, A. Mehling, A. Natsch, J.W. Pitchford, D. Prater, P. Prieto, A. Schepky, G. Schüürmann, L. Smirnova, C. Toole, E. van Vliet, D. Weisensee, T. Hartung. Integrated Testing Strategies (ITS) for safety assessment (2015). ALTEX, 32(1):25-40. doi: http://dx.doi.org/10.14573/altex.1411011. Epub 2014 Nov 19.

86. B. Safford, A.M. Api, C. Barratt, E. Comiskey, E.J. Daly, G. Ellis, C. McNamara, C. O’Mahony, S.H. Robison, B. Smith, R. Thomas, and S. Tozer (2015). Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products. Regul Toxicol Pharmacol. 2015 Aug;72(3):673-82. doi: 10.1016/j.yrtph.2015.05.017. Epub 2015 Jun 10. PMID: 26071898

http://dx.doi.org/10.14573/altex.1411011.%20Epub%202014%20Nov%2019

http://dx.doi.org/10.14573/altex.1411011.%20Epub%202014%20Nov%2019


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87. R.J. Safford, D.W. Roberts, J.F. Lalko, A.M. Api (2015). Extension of the Dermal Sensitization Threshold (DST) approach to incorporate chemicals classified as reactive. Regul Toxicol Pharmacol. 2015 Aug;72(3):694-701. doi: 10.1016/j.yrtph.2015.04.020. Epub 2015 Apr 29. PMID: 25934255

88. L.W. Smith and A.M. Api (2003). Group summaries and fragrance material reviews. Food and Chemical Toxicology, 41(7): 917.

89. C. Svedman, M. Engfeldt, A.M. Api, V.T. Politano, D.V. Belsito, M. Isaksson and M. Bruze (2012). A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test. Contact Dermatitis, 66(3):137-139.

90. C. Svedman, M. Engfeldt, A.M. Api, V.T. Politano, D.V. Belsito, B. Gruvberger and M. Bruze (2012). Does the new standard for eugenol designed to protect against contact sensitization protect those sensitized from elicitation of the reaction? Dermatitis (Formerly American Journal Contact Dermatitis), 23(1): 32-38.


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RIFM Fragrance Ingredient Safety Assessments 1. A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L.

Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, J. Shen, T.W. Schultz, I.G. Sipes, B. Wall, D.K. Wilcox (2015).

RIFM fragrance ingredient safety assessment, 2-Methyl-3-buten-2-ol, CAS registry number 115-18-4. Food Chem Toxicol. pii: S0278-6915(15)00122-2. doi: 10.1016/j.fct.2015.04.013. [Epub ahead of print].

2. A.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, J. Shen, T.W. Schultz, I.G. Sipes, B. Wall, D.K. Wilcox (2015).

RIFM fragrance ingredient safety assessment, Isoborneol, CAS registry number 124-76-5. Food Chem Toxicol. pii: S0278-6915(15)00122-2. doi: 10.1016/j.fct.2015.04.013. [Epub ahead of print]


RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4. Food Chem Toxicol. 2015 Jul 21. pii: S0278-6915(15)30017-X. doi: 10.1016/j.fct.2015.07.009. [Epub ahead of print] PubMed PMID: 26206495.


RIFM fragrance ingredient safety assessment, Benzyl acetate, CAS registry number 140-11-4. Food Chem Toxicol. 2015 Jul 17. pii: S0278-6915(15)30018-1. doi:10.1016/j.fct.2015.07.010. [Epub ahead of print] PubMed PMID: 26192989.


RIFM fragrance ingredient safety assessment, (Z)-2-penten-1-ol, CAS Registry Number 1576-95-0. Food Chem Toxicol. 2015 Jul 2. pii: S0278-6915(15)00221-5. doi:10.1016/j.fct.2015.06.022. [Epub ahead of print] PubMed PMID: 26140953.


RIFM fragrance ingredient safety assessment, (2E,6Z)-Nona-2,6-dien-1-ol, CAS registry number 28069-72-9. Food Chem Toxicol. 2015 Jul 2. pii: S0278-6915(15)00222-7.doi: 10.1016/j.fct.2015.06.023. [Epub ahead of print] PubMed PMID: 26140952.


RIFM fragrance ingredient safety assessment, isophytol, CAS Registry Number 505-32-8. Food Chem Toxicol. 2015 Jun 25. pii: S0278-6915(15)00202-1. doi: 10.1016/j.fct.2015.06.014.[Epub ahead of print] PubMed PMID: 26116883.


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RIFM fragrance ingredient safety assessment, Linalyl hexanoate, CAS Registry Number 7779-23-9. Food Chem Toxicol. 2015 Aug;82 Suppl:S49-58. doi: 10.1016/j.fct.2015.01.009. Epub 2015 Jan 28. PMID: 25636724


RIFM fragrance ingredient safety assessment, Linalyl acetate, CAS Registry Number 115-95-7. Food Chem Toxicol. 2015 Aug;82 Suppl:S39-48. doi: 10.1016/j.fct.2015.01.010. Epub 2015 Jan 28. PMID: 25636725

10. Similar articlesA.M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M.L. Dagli, W. Dekant, A.D. Fryer, L. Kromidas, S. La Cava, J.F. Lalko, A. Lapczynski, D.C. Liebler, Y. Miyachi, V.T. Politano, G. Ritacco, D. Salvito, J. Shen, T.W. Schultz, I.G. Sipes, B. Wall, D.K.

Wilcox (2015). RIFM fragrance ingredient safety assessment, α-amylcinnamaldehyde, CAS registry number 122-40-7. Food Chem Toxicol. 2015 Aug;82 Suppl:S20-8. doi: 10.1016/j.fct.2015.01.008. Epub 2015 Jan 28. PMID: 25636726


RIFM fragrance ingredient safety assessment, methyl dihydrojasmonate, CAS registry number 24851-98-7. (2015) Food Chem Toxicol. 2015 Aug;82 Suppl:S114-21. doi: 10.1016/j.fct.2015.01.006. Epub 2015 Jan 28. PMID: 25636727


RIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6. Food Chem Toxicol. 2015 Aug;82 Suppl:S29-38. doi: 10.1016/j.fct.2015.01.005. Epub 2015 Jan 28.PMID: 25637759


RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9. Food Chem Toxicol. 2015 Aug;82 Suppl:S89-96. doi: 10.1016/j.fct.2015.01.007. Epub 2015 Jan 28.PMID: 25637761


RIFM fragrance ingredient safety assessment, α-Irone, CAS registry number 79-69-6. Food Chem Toxicol. 2015 Aug;82 Suppl:S105-13. doi: 10.1016/j.fct.2015.03.019. Epub 2015 Mar 27. PMID: 25817021


RIFM fragrance ingredient safety assessment, allyl (cyclohexyloxy)acetate, CAS registry number 68901-15-5. Food Chem Toxicol. 2015 Aug;82 Suppl:S59-65. doi: 10.1016/j.fct.2015.03.016. Epub 2015 Mar 27. PMID: 25817022


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RIFM fragrance ingredient safety assessment, ethyl anthranilate, CAS registry number 87-25-2. Food Chem Toxicol. 2015 Aug;82 Suppl:S97-S104. doi: 10.1016/j.fct.2015.03.017. Epub 2015 Mar 25. PMID: 25818467


RIFM fragrance ingredient safety assessment, l-Borneol, CAS registry number 464-45-9. Food Chem Toxicol. 2015 Aug;82 Suppl:S74-80. doi: 10.1016/j.fct.2015.04.013. Epub 2015 Apr 16.


RIFM fragrance ingredient safety assessment, borneol, CAS registry number 507-70-0. Food Chem Toxicol. 2015 Aug;82 Suppl:S81-8. doi: 10.1016/j.fct.2015.04.012. Epub 2015 Apr 15. PMID: 25890088


RIFM fragrance ingredient safety assessment, allyl phenylacetate, CAS registry number 1797-74-6. Food Chem Toxicol. 2015 Aug;82 Suppl:S66-73. doi: 10.1016/j.fct.2015.03.018. Epub 2015 Mar 25. PMID: 25818469


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Fragrance Material Reviews 1. S.P. Bhatia, J. Cocchiara, G.A. Wellington, J.Lalko, C.S. Letizia, A.M. Api (2011).

Fragrance material review on 3-phenylpropyl cinnamate. Food and Chemical Toxicology, 49, Supplement 2: S252-S255.

2. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J.Lalko, C.S. Letizia, A.M. Api (2011). Fragrance material review on 3-phenyl-1-propanol. Food and Chemical Toxicology, 49, Supplement 2: S246-S251.

3. S.P. Bhatia, J. Cocchiara, G.A. Wellington, J.Lalko, C.S. Letizia, A.M. Api (2011). Fragrance material review on 3-phenylpropyl isobutyrate. Food and Chemical Toxicology, 49, Supplement 2: S242-S245.

4. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on Abietyl acetate. Food and Chemical Toxicology, 46(12S1):S28-S29

5. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008).Fragrance Materials Review on Amylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S30-S33

6. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on 3-tert-Butylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1): S34-S35

7. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 4-tert-Butylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S36-S41

8. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on cis-2-tert-Butylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S42-S43

9. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 2-tert-Butylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1): S44-47

10. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on d-Cyclocitronellene acetate. Food and Chemical Toxicology, 46(12S1):S48-S51

11. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Cyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S52-55

12. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on Cyclohexyl cyclopent-2-ene-1-acetate. Food and Chemical Toxicology, 46(12S1):S56-57

13. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008).Fragrance Material Review on Decahydro-β-naphthyl acetate. Food and Chemical Toxicology, 46(12S1):S58-S60

14. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008).Fragrance Material Review on 1-Ethynylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S61-S63

15. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on (3aα,4α,6α,7α,7aα)-3a,4,5,6,7,7a-Hexahydro-3-methyl-5-methylene-4,7-methano-1H-inden-6-yl acetate. Food and Chemical Toxicology, 46(12S1):S64-S67

16. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 4-(Isopropyl)-1-methylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S68-S70

17. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on alpha-Methylcyclohexylmethyl acetate. Food and Chemical Toxicology, 46(12S1):S71-73

18. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 4-Methyl-8 methylenetricyclo[3.3.1.(3,7)] decan-2-yl acetate. Food and Chemical Toxicology, 46(12S1):S74-S78


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19. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on 1-Methyl-2-(1-methylpropyl)cyclohexyl acetate . Food and Chemical Toxicology, 46(12S1):S79-S80

20. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on 1-Methyl-4-(1-methylvinyl)cyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S81-82

21. S.P. Bhatia, C.S. Letizia, A.M. Api,(2008). Fragrance Material Review on 2-(1-Methylpropyl)-1-vinylcyclohexyl acetate. Food and Chemical Toxicology, 46(12S1):S83-S86

22. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Myraldyl acetate. Food and Chemical Toxicology, 46(12S1):S87-S89

23. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on Octahydro-4,7-Methano-1H-indenemethyl acetate. Food and Chemical Toxicology, 46(12S1):S90-S92

24. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Tricyclodecenyl Acetate. Food and Chemical Toxicology, 46(12S1):S93-S96

25. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on Tricyclodecanyl Acetate. Food and Chemical Toxicology, 46(12S1):S97-S99

26. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Materials Review on Tricyclo[5.2.1.02,6]dec-4-en-8-yl acetate. Food and Chemical Toxicology, 46(12S1):S100-S101

27. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 1,7,7-Trimethylbicyclo[4.4.0]dec-3-yl acetate. Food and Chemical Toxicology, 46(12S1):S102-S105

28. S.P. Bhatia, L. Jones, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 1,3,3-Trimethyl-2-norbornanyl acetate. Food and Chemical Toxicology, 46(12S1):S106-S108

29. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on alpha-Bisabolol. Food and Chemical Toxicology, 46(11S):S72-S76.

30. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Borneol. Food and Chemical Toxicology, 46(11S):S77-S80.

31. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on l-Borneol. Food and Chemical Toxicology, 46(11S):S81-S84.

32. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Carveol Food and Chemical Toxicology, 46(11S):S85-S87.

33. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M.Api (2008). Fragrance Material Review on l-Carveol. Food and Chemical Toxicology, 46(11S):S88-S90.

34. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 4-Carvomenthenol. Food and Chemical Toxicology, 46(11S):S91-S94.

35. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M.Api (2008). Fragrance Material Review on beta-Caryophyllene alcohol. Food and Chemical Toxicology, 46(11S):S95-S96.

36. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Cedrenol. Food and Chemical Toxicology, 46(11S):S97-S99.

37. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Cedrol. Food and Chemical Toxicology, 46(11S):S100-S102.

http://www.rifm.org/data/materialEntry.cfm?CASNumber=24238-95-7

http://www.rifm.org/data/materialEntry.cfm?CASNumber=24238-95-7


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38. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Dihydrocarveol (R,R,R). Food and Chemical Toxicology, 46(11S):S121-S122.

39. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Dihydrocarveol (isomer unspecified). Food and Chemical Toxicology, 46(11S):S123-S125.

40. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Dihydro-alpha-terpineol. Food and Chemical Toxicology, 46(11S):S128-S130.

41. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Elemol. Food and Chemical Toxicology, 46(11S):S147-S148.

42. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Fenchyl alcohol. Food and Chemical Toxicology, 46(11S):S157-S159.

43. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Geranodyle. Food and Chemical Toxicology, 46(11S):S171-S175.

44. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M .Api (2008). Fragrance Material Review on Isoborneol. Food and Chemical Toxicology, 46(11S):S182-S184.

45. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Isopulegol. Food and Chemical Toxicology, 46(11S):S185-S189.

46. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on p-Mentha-1,8-dien-7-ol. Food and Chemical Toxicology, 46(11S):S197-S200.

47. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on cis-p-Menthan-7-ol. Food and Chemical Toxicology, 46(11S):S201-S203.

48. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on p-Menth-1-en-8-ol (S). Food and Chemical Toxicology, 46(11S):S204-205.

49. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on p-Menth-8-en-1-ol. Food and Chemical Toxicology, 46(11S):S206-S208.

50. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Menthol. Food and Chemical Toxicology, 46(11S):S209-S214.

51. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on d-Menthol. Food and Chemical Toxicology, 46(11S):S215-S217.

52. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on l-Menthol. Food and Chemical Toxicology, 46(11S):S218-S223.

53. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on d,l-Menthol (isomer unspecified). Food and Chemical Toxicology, 46(11S):S224-S227.

54. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Menthol racemic. Food and Chemical Toxicology, 46(11S):S228-S233.


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55. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M.Api (2008). Fragrance Material Review on Myrtenol. Food and Chemical Toxicology, 46(11S):S237-S240.

56. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Octahydro-7,7,8,8-tetramethyl-2,3b-methano-3bH-cyclopenta(1,3) cyclopropa(1,2) benzene-4-methanol. Food and Chemical Toxicology, 46(11S):S253-S254.

57. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Patchouli alcohol. Food and Chemical Toxicology, 46(11S):S255-S256.

58. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 2(10)-Pinen-3-ol. Food and Chemical Toxicology, 46(11S):S257-S258.

59. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Santalol. Food and Chemical Toxicology, 46(11S):S263-S266.

60. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on alpha-Santalol. Food and Chemical Toxicology, 46(11S):S267-S269.

61. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Sclareol. Food and Chemical Toxicology, 46(11S):S270-S274.

62. S.P. Bhatia, D. McGinty, Foxenberg, R.J., C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Terpineol. Food and Chemical Toxicology, 46(11S):S275-S279.

63. S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on alpha-Terpineol. Food and Chemical Toxicology, 46(11S):S280-S285.

64. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on 4-Thujanol. Food and Chemical Toxicology, 46(11S):S295-S296.

65. S.P. Bhatia, D. McGinty, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Vetiverol. Food and Chemical Toxicology, 46(11S):S297-S301.

66. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on allyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S24-S28.

67. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-amylcinnamyl alcohol. Food and Chemical Toxicology, 45(Supplement 1):S32-S39.

68. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on benzyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S40-S48.

69. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on butyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S49-S52.

70. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl acetate. Food and Chemical Toxicology, 45(Supplement 1):S53-S57.


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71. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl benzoate. Food and Chemical Toxicology, 45(Supplement 1):S58-S61.

72. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl butyrate. Food and Chemical Toxicology, 45(Supplement 1):S62-S65.

73. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S66-S69.

74. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl formate. Food and Chemical Toxicology, 45(Supplement 1):S70-S73.

75. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl isobutyrate. Food and Chemical Toxicology, 45(Supplement 1):S74-S77.

76. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl isovalerate. Food and Chemical Toxicology 45(Supplement 1):S78-S81.

77. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl propionate. Food and Chemical Toxicology, 45(Supplement 1):S82-S85.

78. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cinnamyl tiglate. Food and Chemical Toxicology, 45(Supplement 1):S86-S89.

79. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on ethyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S90-S94.

80. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on cis-3-hexenyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S95-S97.

81. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on isoamyl cinnamate. . Food and Chemical Toxicology, 45(Supplement 1):S98-S101.

82. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on isobutyl cinnamate Food and Chemical Toxicology, 45(Supplement 1):S102-S105.

83. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on isopropyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S106-S109.

84. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Addendum to the fragrance material review on linalyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S110-S112.

85. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on methyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S113-S119.


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86. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-methylcinnamic alcohol. Food and Chemical Toxicology, 45(Supplement 1):S120-S124.

87. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on pentyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S29-S31.

88. S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia and A.M. Api (2007). Fragrance material review on phenethyl cinnamate. Food and Chemical Toxicology, 45(Supplement 1):S125-S129.

89. J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on allyl alpha-ionone. Food and Chemical Toxicology, 45(Supplement 1):S168-S171.

90. J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material Review on beta-Ionone. Food and Chemical Toxicology, 45(Supplement 1):S241-S247.

91. J. Lalko, A. Lapczynski, V.T. Politano, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-ionone. Food and Chemical Toxicology, 45(Supplement 1):S235-S240.

92. J. Lalko, A.Lapczynski, C.S. Letizia and A.M. Api (2007). Fragrance material review on cis-beta-damascone. Food and Chemical Toxicology 45(Supplement 1):S192-S198.

93. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on delta-damascone. Food and Chemical Toxicology, 45(Supplement 1):S205-S210.

94. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on gamma-damascone. Food and Chemical Toxicology, 45(Supplement 1):S216-S220.

95. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on dihydro-alpha-ionone. Food and Chemical Toxicology, 45(Supplement 1):S221-S224.

96. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on dihydro-beta-ionone. Food and Chemical Toxicology, 45(Supplement 1):S225-S228.

97. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on dihydro-gamma-ionone. Food and Chemical Toxicology, 45(Supplement 1):S229-S231.

98. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on 4-(1,2-epoxy-2,6,6-trimethylcyclohexyl)-3-buten-2-one. Food and Chemical Toxicology, 45(Supplement 1):S232-S234.

99. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on trans-beta-ionone. Food and Chemical Toxicology, 45(Supplement 1):S248-S250.

100. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on ionone. Food and Chemical Toxicology, 45(Supplement 1):S251-S257.


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101. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-irone. Food and Chemical Toxicology, 45(Supplement 1):S272-S275.

102. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on isodamascone. Food and Chemical Toxicology, 45(Supplement 1):S258-S262.

103. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on isodamascone (isomer unspecified). Food and Chemical Toxicology, 45(Supplement 1):S263-S266.

104. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on 6-methyl-beta-ionone. Food and Chemical Toxicology, 45(Supplement 1):S294-S296.

105. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on iso-methyl-beta-ionone. Food and Chemical Toxicology, 45(Supplement 1):S297-S299.

106. J. Lalko, A.Lapczynski, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on methyl ionone (mixture of isomers). Food and Chemical Toxicology, 45(Supplement 1):S300-S307.A. Lapczynski, D. McGinty, L. Jones, C.S. Letizia, and A.M. Api (2007). Fragrance material review on p-cresyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S385-S388.

107. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api 2008. Fragrance Material Review on dl-Citronellol. Food and Chemical Toxicology, 46(11S):S103-S109.

108. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on l-Citronellol. Food and Chemical Toxicology, 46(11S):S110-S113.

109. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on (+)-(R) Citronellol. Food and Chemical Toxicology, 46(11S):S114-S126.

110. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api 2008). Fragrance Material Review on Dehydrolinalool. Food and Chemical Toxicology, 46(11S):S117-S120.

111. A. Lapczynski, Letizia, C.S., A.M. Api (2008). Fragrance Material Review on 3,7, Dimethyloct-1-en-3-ol. Food and Chemical Toxicology, 46(11S):S126-S127.

112. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on (3E,5Z)-2,6-Dimethylocta-3,5-dien-2-ol. Food and Chemical Toxicology, 46(11S):S131-S132.

113. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on (3E,5E)-2,6-Dimethylocta-3,5-dien-2-ol. Food and Chemical Toxicology, 46(11S):S133-S134.

114. A. Lapczynski, Letizia, C.S., A.M. Api (2008). Fragrance Material Review on trans-3,7-Dimethyl-1,6-octadien-3-ol. Food and Chemical Toxicology, 46(11S):S135-S136.

115. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on 3,7-Dimethyl-4,6-octadien-3-ol. Food and Chemical Toxicology, 46(11S):S137-S138.


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116. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on 3,7-Dimethyl-1-octanol. Food and Chemical Toxicology, 46(11S):S139-S141.

117. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on 3,7-Dimethyloct-6-en-3-ol. Food and Chemical Toxicology, 46(11S):S142-S143.

118. A. Lapczynski, Bhatia, S.P., Letizia, C.S., A.M. Api (2008). Fragrance Material Review on 3,7-Dimethyloct-7-en-1-ol. Food and Chemical Toxicology, 46(11S):S144-S146.

119. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Farnesol. Food and Chemical Toxicology, 46(11S):S149-S156.

120. A. Lapczynski, S.P. Bhatia, R.J. Foxenberg, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Geraniol. Food and Chemical Toxicology, 46(11S):S160-S170.

121. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Geranyl linalool. Food and Chemical Toxicology, 46(11S):S176-S178.

122. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Hydroxycitronellol. Food and Chemical Toxicology, 46(11S):S179-S181.

123. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Addendum to the Fragrance Material Review on Linalool. Food and Chemical Toxicology, 46(11S):S190-S192.

124. A. Lapczynski, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on d-Linalool. Food and Chemical Toxicology, 46(11S):S193-S194.

125. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on l-Linalool. Food and Chemical Toxicology, 46(11S):S195-S196.

126. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Myrcenol. Food and Chemical Toxicology, 46(11S):S234-S236.

127. A. Lapczynski, R.J. Foxenberg, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Nerol. Food and Chemical Toxicology, 46(11S):S241-S244.

128. A. Lapczynski, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on cis-Nerolidol. Food and Chemical Toxicology, 46(11S):S245-S246.

129. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Nerolidol (isomer unspecified). Food and Chemical Toxicology, 46(11S):S247-S250.

130. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Ocimenol. Food and Chemical Toxicology, 46(11S):S251-S252.

131. A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Rhodinol. Food and Chemical Toxicology, 46(11S):S259-S262.

132. A. Lapczynski, R.J. Foxenberg, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Tetrahydrolinalool. Food and Chemical Toxicology, 46(11S):S286-S288.


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133. A. Lapczynski, R.J. Foxenberg, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Tetrahydromuguol. Food and Chemical Toxicology, 46(11S):S289-S291.

134. A. Lapczynski, R.J. Foxenberg, S.P. Bhatia, C.S. Letizia, A.M. Api (2008). Fragrance Material Review on Tetrahydromyrcenol. Food and Chemical Toxicology, 46(11S):S292-S294.

135. A. Lapczynski, D. McGinty, L. Jones, C.S. Letizia, and A.M. Api (2007). Fragrance material review on ethyl hexyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S393-S396.

136. A. Lapczynski, D. McGinty, L. Jones, C.S. Letizia, and A.M. Api (2007). Fragrance material review on cis-3-hexenyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S402-S405.

137. A. Lapczynski, D. McGinty, L. Jones, C.S. Letizia, and A.M. Api (2007). Fragrance material review on trans-2-hexenyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S406-S409.

138. A. Lapczynski, D. Mcginty, L. Jones, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on benzyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S362-S380.

139. A. Lapczynski, D. Mcginty, L. Jones, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on ethyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S397-S401.

140. A. Lapczynski, D. McGinty, L. Jones, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on pentyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S460-S466.

141. A. Lapczynski, D. McGinty, L. Jones, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on phenethyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S467-S471.

142. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on damascenone. Food and Chemical Toxicology, 45(Supplement 1):S172-S178.

143. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-damascone. Food and Chemical Toxicology, 45(Supplement 1):S179-S187.

144. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on cis-alpha-damascone. Food and Chemical Toxicology 45(Supplement 1):S188-S191.

145. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on fragrance material review on trans-beta-damascone. Food and Chemical Toxicology, 45(Supplement 1):S199-S204.

146. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on trans, trans-delta-damascone. Food and Chemical Toxicology, 45(Supplement 1):S211-S215.

147. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-isodamascone. Food and Chemical Toxicology, 45(Supplement 1):S267-S271.


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148. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on methyl-alpha-ionone. Food and Chemical Toxicology, 45(Supplement 1):S276-S279.

149. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on methyl-beta-ionone. Food and Chemical Toxicology, 45(Supplement 1):S290-S293.

150. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on 3-methyl-4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-3-buten-2-one. Food and Chemical Toxicology, 45(Supplement 1):S308-S310.

151. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on 4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-3-buten-2-one. Food and Chemical Toxicology, 45(Supplement 1):S311-S314.

152. A. Lapczynski, J. Lalko, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on 4-(3,5,6-trimethyl-3-cyclohexen-1-yl)-3-buten-2-one. Food and Chemical Toxicology, 45(Supplement 1):S315-S317.

153. A. Lapczynski, J. Lalko, V.T. Politano, D. McGinty, S. Bhatia, C.S. Letizia and A.M. Api (2007). Fragrance material review on alpha-iso-methylionone. Food and Chemical Toxicology, 45(Supplement 1):S280-S289.

154. A. Lapczynski, L. Jones, D. McGinty, C.S. Letizia, and A.M. Api (2007). Fragrance material review on phenyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S472-S476.

155. A. Lapczynski, L. Jones, D. McGinty, C.S. Letizia, And A.M. Api (2007). Fragrance material review on 3-methyl-2-butenyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S453-S456.

156. A. Lapczynski, L. Jones, D. Mcginty, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on butyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S381-S384.

157. A. Lapczynski, L. Jones, D. Mcginty, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on hexyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S410-S417.

158. A. Lapczynski, L. Jones, D. Mcginty, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on isoamyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S418-S423.

159. A. Lapczynski, L. Jones, D. Mcginty, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on isobutyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S424-S427.

160. A. Lapczynski, L. Jones, D. McGinty, S.P. Bhatia, C.S. Letizia, and A.M. Api (2007). Fragrance material review on methyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S428-S452.

161. C.S. Letizia, J. Cocchiara, G.A. Wellington, C. Funk and A.M. Api (2000). Monographs on fragrance raw materials, Special Issue IX. Food and Chemical Toxicology, 38(Supplement 3):S1-S236.

162. C.S. Letizia, J. Cocchiara, J. Lalko, A. Lapczynski and A.M. Api (2004). Fragrance material review on cinnamaldehyde. Submitted to Food and Chemical Toxicology.


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163. C.S. Letizia, J. Cocchiara, J. Lalko, A. Lapczynski and A.M. Api (2004). Fragrance material review on cinnamic acid. Submitted to Food and Chemical Toxicology.

164. C.S. Letizia, J. Cocchiara, J. Lalko, A. Lapczynski and A.M. Api (2004). Fragrance material review on cinnamyl alcohol. Submitted to Food and Chemical Toxicology.

165. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalool. Food and Chemical Toxicology, 41(7): 943-964.

166. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl acetate. Food and Chemical Toxicology, 41(7): 965-976.

167. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl benzoate. Food and Chemical Toxicology, 41(7): 977-981.

168. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl butyrate. Food and Chemical Toxicology, 41(7): 983-987.

169. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl cinnamate. Food and Chemical Toxicology, 41(7): 989-993.

170. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl formate. Food and Chemical Toxicology, 41(7): 995-999.

171. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl hexanoate. Food and Chemical Toxicology, 41(7): 1001-1004.

172. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl isogutyrate. Food and Chemical Toxicology, 41(7): 1005-1010.

173. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl isovalerate. Food and Chemical Toxicology, 41(7): 1011-1015.

174. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl phenylacetate. Food and Chemical Toxicology, 41(7): 1017-1021.

175. C.S. Letizia, J. Cocchiara, J. Lalko and A.M. Api (2003). Fragrance material review on linalyl propionate. Food and Chemical Toxicology, 41(7): 1023-1027.

176. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,3-dimethyl-3-phenylbutyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S314-S318

177. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1-phenyl-3-methyl-3-pentyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S319-S322

178. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,1-dimethyl-2-phenylethyl prop50,ionate. Food and Chemical Toxicology, 50, Supplement 2:S323-S326

179. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,2-ethanediol, 1-phenyl-, 1,2-diacetate. Food and Chemical Toxicology, 50, Supplement 2:S327-S329

180. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,3-benzodioxole-5-propanol, α-methyl-,5-acetate -. Food and Chemical Toxicology, 50, Supplement 2:S330-S332

181. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl 2- hydroxypropionate. Food and Chemical Toxicology, 50, Supplement 2:S333-S336

182. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on anisyl propionate. Food and Chemical Toxicology, 50, Supplement 2:S337-S340


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183. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on (4-methoxyphenyl)methyl isobutyrate. Food and Chemical Toxicology, 50, Supplement 2:S341-S343

184. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,1-dimethyl-2-phenylethyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S344-S349

185. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,1-dimethyl-2-phenylethyl isobutyrate. Food and Chemical Toxicology, 50, Supplement 2:S350-S352

186. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,1-dimethyl-2-phenylethyl formate. Food and Chemical Toxicology, 50, Supplement 2:S353-S357

187. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on piperonyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S358-S362

188. D. McGinty, D. Vitale, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S363-S384

189. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on α-methylbenzyl isobutyrate. Food and Chemical Toxicology, 50, Supplement 2:S385-S387

190. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on α-methylbenzyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S388-S393

191. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on p-isopropylbenzyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S394-S397

192. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on phenethyl butyrate. Food and Chemical Toxicology, 50, Supplement 2:S398-S401

193. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl formate. Food and Chemical Toxicology, 50, Supplement 2:S402-S406

194. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl butyrate. Food and Chemical Toxicology, 50, Supplement 2:S407-S411

195. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on α-methylbenzyl propionate. Food and Chemical Toxicology, 50, Supplement 2:S412-S415

196. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on phenethyl isobutyrate. Food and Chemical Toxicology, 50, Supplement 2:S416-S419

197. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl isobutyrate. Food and Chemical Toxicology, 50, Supplement 2:S420-S424

198. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on phenethyl formate. Food and Chemical Toxicology, 50, Supplement 2:S425-S429

199. D. McGinty, D. Vitale, C.S. Letizia, A.M. Api (2012). Fragrance material review on phenethyl propionate. Food and Chemical Toxicology, 50, Supplement 2:S430-S434

200. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-methyl-4-phenyl-2-butyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S435-S438

201. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1,1-dimethyl-2-phenylethyl butyrate. Food and Chemical Toxicology, 50, Supplement 2:S439-S442

202. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2,4-dimethylbenzyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S443-S447

203. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-hydroxy-2-phenylethyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S448-S450


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204. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-phenoxyethyl isobutyrate. Food and Chemical Toxicology, 50, Supplement 2:S451-S456

205. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-phenylpropyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S457-S461

206. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-phenyl-3-buten-1-yl acetate. Food and Chemical Toxicology, 50, Supplement 2:S462-S466

207. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on anisyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S467-S470

208. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on anisyl formate. Food and Chemical Toxicology, 50, Supplement 2:S471-S474

209. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 4-methylbenzyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S475-S478

210. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on carbonic acid, methyl phenylmethyl ester. Food and Chemical Toxicology, 50, Supplement 2:S479-S482

211. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-(p-tolyoxy)ethyl formate. Food and Chemical Toxicology, 50, Supplement 2:S483-S485

212. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl propionate. Food and Chemical Toxicology, 50, Supplement 2:S486-S490

213. D. McGinty, D. Vitale, C.S. Letizia, A.M. Api (2012). Fragrance material review on phenethyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S491-S497

214. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-phenoxyethyl propionate. Food and Chemical Toxicology, 50, Supplement 2:S498-S501

215. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on p-anisyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S502-S506

216. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-phenylpropyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S507-S511

217. D. McGinty, C.S. Letizia, A.M. Api (2012). Fragrance material review on ethyl phenyl carbinyl acetate. Food and Chemical Toxicology, 50, Supplement 2:S512-S515

218. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on 16-hydroxy-7-hexadecenoic acid lactone. Food and Chemical Toxicology, 49, Supplement 2:S149-S151.

219. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on E- and Z-oxacyclohexadec-12(+13)-en-2-one. Food and Chemical Toxicology, 49, Supplement 2:S152-S157

220. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on 10-oxahexadecanolide. Food and Chemical Toxicology, 49, Supplement 2:S158-S162.



223. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on ethylene brassylate. Food and Chemical Toxicology, 49, Supplement 2:S174-S182.


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224. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on hexadecanolide. Food and Chemical Toxicology, 49, Supplement 2:S183-S188.

225. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on oxacycloheptadec-10-ene-2-one. Food and Chemical Toxicology, 49, Supplement 2:S189-S192.

226. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on ω-pentadecalactone. Food and Chemical Toxicology, 49, Supplement 2:S193-S201.

227. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on oxacyclohexadecane-2,13-dione. Food and Chemical Toxicology, 49, Supplement 2:S202-S206.

228. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on ω-6-hexadecenlactone. Food and Chemical Toxicology, 49, Supplement 2:S207-S211.

229. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on ethylene dodecanedioate. Food and Chemical Toxicology, 49, Supplement 2:S212-S218.

230. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on 3-methylcyclopentadecenone (mixed isomers). Food and Chemical Toxicology, 49, Supplement 2: S85-S92.

231. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on cycloheptadeca-9-en-1-one. Food and Chemical Toxicology, 49, Supplement 2: S93-S97.

232. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on 5-cyclohexadecen-1-one. Food and Chemical Toxicology, 49, Supplement 2: S98-S103.

233. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on cyclohexadecanone. Food and Chemical Toxicology, 49, Supplement 2: S104-S108.

234. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on cyclohexadec-8-en-1-one (mixture of cis and trans isomers). Food and Chemical Toxicology, 49, Supplement 2: S109-S111.

235. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on 4-cyclopentadecen-1-one, (Z)-,. Food and Chemical Toxicology, 49, Supplement 2: S112-S116.

236. D. McGinty, C.S. Letizia, A.M. Api (2011) Fragrance material review on 4-cyclopentadecen-1-one. Food and Chemical Toxicology, 49, Supplement 2: S117-S119.

237. D. McGinty, C.S. Letizia, A.M. Api (2011). Fragrance material review on 3-methyl-1-cyclopentadecanone. Food and Chemical Toxicology, 49, Supplement 2: S120-S125.

238. D. McGinty, C.s. Letizia, A.M. Api (2011). Fragrance material review on cyclopentadecanone. Food and Chemical Toxicology, 49, Supplement 2: S142-S148.

239. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 3,5,5-trimethyl-1-hexanol. Food and Chemical Toxicology, 48, Supplement 4: S47-S50.

240. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 3,7-dimethyl-7-methoxyoctan-2-ol. Food and Chemical Toxicology, 48, Supplement 4: S51-S54.

241. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 4-methyl-2-pentanol. Food and Chemical Toxicology, 48, Supplement 4: S55-S59.

242. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2-methylundecanol. Food and Chemical Toxicology, 48, Supplement 4: S60-S62.


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243. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 3,4,5,6,6-pentamethylheptan-2-ol. Food and Chemical Toxicology, 48, Supplement 4: S63-S66.

244. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on isodecyl alcohol. Food and Chemical Toxicology, 48, Supplement 4: S67-S69.

245. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on isooctan-1-ol. Food and Chemical Toxicology, 48, Supplement 4: S70-S72.

246. D. McGinty, S.P. Bhatia, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on isotridecan-1-ol (isomeric mixture). Food and Chemical Toxicology, 48, Supplement 4: S73-S78.

247. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on isononyl alcohol. Food and Chemical Toxicology, 48, Supplement 4: S79-S81.

248. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api ( 2010). Fragrance material review on 6,8-dimethylnonan-2-ol. Food and Chemical Toxicology, 48, Supplement 4: S82-S84.

249. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2-ethyl-1-butanol. Food and Chemical Toxicology, 48, Supplement 4: S85-S88.

250. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2,6-dimethyl-4-heptanol. Food and Chemical Toxicology, 48, Supplement 4: S89-S92.

251. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 3-methyl-1-pentanol. Food and Chemical Toxicology, 48, Supplement 4: S93-S96.

252. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2-methylbutanol. Food and Chemical Toxicology, 48, Supplement 4: S97-S101.

253. D. McGinty, A. Lapczynski, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance materials review on isoamyl alcohol. Food and Chemical Toxicology, 48, Supplement 4: S102-S109.

254. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2,6-dimethyl-2-heptanol. Food and Chemical Toxicology, 48, Supplement 4: S110-S114.

255. D. McGinty, J. Scognamiglio, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2-ethyl-1-hexanol. Food and Chemical Toxicology, 48, Supplement 4: S115-S129.

256. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on 3,5,6,6-tetramethyl-4-methyleneheptan-2-ol. Food and Chemical Toxicology, 48, Supplement 3: S89-S90.

257. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on (2E,6Z)-nona-2,6-dien-1-ol. Food and Chemical Toxicology, 48, Supplement 3: S91-S92.

258. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2,6,10-trimethylundeca-5,9-dienol. Food and Chemical Toxicology, 48, Supplement 3: S87-S88.

259. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance Material Review on 6-ethyl-3-methyloct-6-en-1-ol. Food and Chemical Toxicology, 48, Supplement 3: S108-S110.

260. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2-hexadecen-1-ol, 3,7,11,15-tetramethyl. Food and Chemical Toxicology, 48, Supplement 3: S101-S102.

261. D. McGinty, C.S. Letizia, A.M. Api (2010). Addendum to Fragrance material review on Nerolidol (isomer unspecified). Food and Chemical Toxicology, 48, Supplement 3: S43-S45


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262. D. McGinty, L. Jones, C.S. Letizia, A.M. Api (2010). Fragrance material review on 3-methyl-2-buten-1-ol. Food and Chemical Toxicology, 48, Supplement 3: S64-S69.

263. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on methylheptenol, Food and Chemical Toxicology S56-S58

264. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on isophytol, Food and Chemical Toxicology. Food and Chemical Toxicology, 48, Supplement 3: S76-S81

265. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on 2-methyl-2-hepten-6-ol. Food and Chemical Toxicology, 48, Supplement 3: S82-S83

266. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on dihydromyrcenol. Food and Chemical Toxicology, 48, Supplement 3: S70-S75

267. D. McGinty, A. Lapczynski, S.P. Bhatia, C.S. Letizia, A.M. Api (2010). Fragrance material review on 7-octen-2-ol, 2-methyl-6-methylene-, dihydro derivative. Food and Chemical Toxicology, 48, Supplement 3: S46-S51

268. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on (Z)-2-penten-1-ol. Food and Chemical Toxicology, 48, Supplement 3: S84-S86

269. D. McGinty, L. Jones, C.S. Letizia, A.M. Api (2010). Fragrance material review on 7-nonen-2-ol, 4,8-dimethyl-. Food and Chemical Toxicology, 48, Supplement 3: S103-S107

270. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on phytol. Food and Chemical Toxicology, 48, Supplement 3: S59-S63

271. D. McGinty, C.S. Letizia, A.M. Api, Fragrance material review on 2-methyl-3-buten-2-ol. Food and Chemical Toxicology, 48, Supplement 3: S97-S100

272. D. McGinty, C.S. Letizia, A.M. Api, Fragrance material review on 3,7-dimethyl-1,6-nonadien-3-ol. Food and Chemical Toxicology, 48, Supplement 3: S52-S55

273. D. McGinty, C.S. Letizia, A.M. Api (2010). Fragrance material review on 4-methyl-3-decen-5-ol. Food and Chemical Toxicology, 48, Supplement 3: S93-S96

274. D. McGinty, C.S. Letizia, and A.M. Api (2007). Fragrance material review on 1,3-dimethyl-3-butenyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S389-S392.

275. D. McGinty, C.S. Letizia, and A.M. Api (2007). Fragrance material review on methyl-4-methyl salicylate. Food and Chemical Toxicology, 45(Supplement 1):S457-S459.

276. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one. Food and Chemical Toxicology, 62,Supplement 1:S45-S50

277. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 2-cyclohexyl-1,6-heptadien-3-one. Food and Chemical Toxicology, 62,Supplement 1:S51-S55

278. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(3,3-dimethylcyclohexyl)ethan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S56-S60

279. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on on 1-[5 (or 6)-methyl-7 (or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S61-S66

280. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on methyl-2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone. Food and Chemical Toxicology, 62,Supplement 1:S67-S73


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281. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(5,5-dimethylcyclohexen-1-yl)pent-4-en-1-one. Food and Chemical Toxicology, 62,Supplement 1:S74-S82

282. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one. Food and Chemical Toxicology, 62,Supplement 1:S83-S89

283. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one. Food and Chemical Toxicology, 62,Supplement 1:S90-S94

284. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(2,4-dimethyl-3-cyclohexenyl)-2,2-dimethyl-propan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S95-S99

285. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S100-S105

286. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(3,5,6-trimethyl-3-cyclohexen1-yl)ethan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S106-S109

287. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(3,5,6-trimethyl-3-cyclohexen1-yl)ethan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S110-S114

288. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one. Food and Chemical Toxicology, 62,Supplement 1:S115-S119

289. J. Scognamiglio, C.S. Letizia, V.T. Politano, A.M. Api (2013). Fragrance material review on 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE). Food and Chemical Toxicology, 62,Supplement 1:S120-S132

290. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(para-menthen-6-yl)-1-propanone. Food and Chemical Toxicology, 62,Supplement 1:S133-S137

291. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on cyclohexyl methyl pentanone. Food and Chemical Toxicology, 62,Supplement 1:S138-S143

292. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on 1-(2,5,5-trimethylcycloheptyl)ethan-1-one. Food and Chemical Toxicology, 62,Supplement 1:S144-S147

293. J. Scognamiglio, C.S. Letizia, A.M. Api (2013). Fragrance material review on acetyl carene. Food and Chemical Toxicology, 62,Supplement 1:S148-S151

294. J. Scognamiglio, C.S. Letizia, V.T. Politano, A.M. Api (2013). Fragrance material review on acetyl cedrene. Food and Chemical Toxicology, 62,Supplement 1:S152-S166.

295. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-methyl-2-(pentyloxy)-2-cyclopenten-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S557-S561

296. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on methyl dihydrojasmonate. Food and Chemical Toxicology, Volume 50, Supplement 3:S562-S571


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297. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on methyl jasmonate. Food and Chemical Toxicology, Volume 50, Supplement 3:S572-S576

298. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-heptylidenecyclopentan-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S577-S581

299. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on methyl hexyl oxo cyclopentanone carboxylate. Food and Chemical Toxicology, Volume 50, Supplement 3:S582-S585

300. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on isojasmone. Food and Chemical Toxicology, Volume 50, Supplement 3:S586-S591

301. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on cyclotene propionate. Food and Chemical Toxicology, Volume 50, Supplement 3:S592-S595

302. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on methyl 3-oxo-2-(pent-2-enyl)cyclopentane acetate. Food and Chemical Toxicology, Volume 50, Supplement 3:S596-S599

303. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on dihydroisojasmone. Food and Chemical Toxicology, Volume 50, Supplement 3:S600-S603

304. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on hexenylcyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S604-S607

305. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on cyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S608-S612

306. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on cis-jasmone. Food and Chemical Toxicology, Volume 50, Supplement 3:S613-S618

307. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-heptylcyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S619-S624

308. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-hexylcyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S625-S630

309. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-hexylidene cyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S631-S640

310. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-pentylcyclopentan-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S641-S645

311. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-ethyl-2-hydroxy-2-cyclopenten-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S646-S649

312. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-methyl-2-(2-pentenyl)-2-cyclopenten-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S650-S652


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313. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-methyl-2-(n-pentanyl)-2-cyclopenten-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S653-S657

314. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-methyl-2-pentylcyclopentan -1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S658-S660

315. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-cyclopentylcyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S661-S663

316. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-hydroxy-3,4-dimethyl2-cyclopenten-1-one. Food and Chemical Toxicology, Volume 50, Supplement 3:S664-S667

317. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2,2,5-trimethyl-5-pentylcyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S668-S672

318. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-(p-menth-1-ene-10-yl) cyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S673-S677

319. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-(3,7-dimethyl-2,6-octadienyl)cyclopentanone. Food and Chemical Toxicology, Volume 50, Supplement 3:S678-S681.

320. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-methyl-5-phenylpentanol. Food and Chemical Toxicology, 50, Supplement 2: S100-S104

321. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 3-methyl-1-phenylbutan-2-ol. Food and Chemical Toxicology, 50, Supplement 2: S105-S107

322. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on p-tolyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S108-S112

323. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on p-α, α-trimethylbenzyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S113-S116

324. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on anisyl alcohol (o-m-p-). Food and Chemical Toxicology, 50, Supplement 2: S117-S119

325. J. Scognamiglio, C.S. Letizia, A.M. Api (2012). Fragrance material review on 4-phenyl-3-buten-2-ol. Food and Chemical Toxicology, 50, Supplement 2: S120-S123

326. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on α-methylbenzyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S124-S129

327. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-phenyl-2-propanol. Food and Chemical Toxicology, 50, Supplement 2: S130-S133

328. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on anisyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S134-S139

329. J. Scognamiglio, L. Jones, D. Vitale, C.S. Letizia, A.M. Api (2012). Fragrance material review on benzyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S140-S160


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330. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on p-isopropylbenzyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S161-S164

331. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on p-isopropylbenzyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S165-S167

332. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 1-phenyl- 3-methyl-3-pentanol. Food and Chemical Toxicology, 50, Supplement 2: S168-S172

333. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-(3-methylphenyl) ethanol. Food and Chemical Toxicology, 50, Supplement 2: S173-S175

334. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-(4-methylphenoxy) ethanol. Food and Chemical Toxicology, 50, Supplement 2: S176-S179

335. J. Scognamiglio, C.S. Letizia, A.M. Api (2012). Fragrance material review on β-methoxy-benzeneethanol. Food and Chemical Toxicology, 50, Supplement 2: S180-S183

336. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-methyl-4-phenyl-2-butanol. Food and Chemical Toxicology, 50, Supplement 2: S184-S188

337. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on α, α-dimethylphenethyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S189-S194

338. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on α-isobutylphenethyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S195-S198

339. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on β-methylphenethyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S199-S203

340. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2,2-dimethyl-3-phenylpropanol. Food and Chemical Toxicology, 50, Supplement 2: S204-S208



343. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on α-propylphenethyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S220-S223

344. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on phenylethyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S224-S239

345. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on o-tolylethanol. Food and Chemical Toxicology, 50, Supplement 2: S240-S243

346. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-phenoxyethanol. Food and Chemical Toxicology, 50, Supplement 2: S244-S255

347. J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api (2012). Fragrance material review on 2-benzylheptanol. Food and Chemical Toxicology, 50, Supplement 2: S256-S258

348. J. Scognamiglio, C.S. Letizia, A.M. Api (2012). Fragrance material review on α,α,4-trimethylphenethyl alcohol. Food and Chemical Toxicology, 50, Supplement 2: S259-S262


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349. J. Scognamiglio, C.S. Letizia, A.M. Api (2012). Fragrance material review on β,β,3-trimethyl-benzenepropanol. Food and Chemical Toxicology, 50, Supplement 2: S263-S268.


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Monographs 1. R.A. Ford, A.M. Api and C.S. Letizia (1992). Monographs on fragrance raw materials. Food

Chem Toxicol. 30 Suppl:1S-138S.

2. R.A. Ford, A.M. Api and C.S. Letizia (1988). Monographs on fragrance raw materials. Food Chem Toxicol. 26(4):273-415.


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Posters 1. A.M. Api, S. Bhatia, C. Letizia, D. McGinty, J. Scognamiglio and L.W. Smith (2011). A

Group Approach For Human Health Safety Assessment Of Fragrance Ingredients. Society of Toxicology 50th Annual Meeting, March 6-10, 2011, Washington, D.C., USA. The Toxicologist, 120(Suppl. 2), 105.

2. A.M. Api, J. Lalko, V.T. Politano (2009). The Use of Human Data When Conducting Dermal Sensitization Quantitative Risk Assessments for Fragrance Ingredients; How well does the LLNA predict Human NOELs? Society of Toxicology 48th Annual Meeting, March 15-19, 2009, Baltimore, Maryland, USA. The Toxicologist, 108(1), 26-27.

3. A.M. Api, D.A. Basketter, P.A. Cadby, M-F. Cano, G. Ellis, G.F. Gerberick, P. Griem, P.M. McNamee, C.A. Ryan and B. Safford (2006). Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients. FDA Science Forum, 18-20, April 2006, Washington, D.C., USA.

4. A.M. Api, D.A. Basketter, P.A. Cadby, M-F. Cano, G. Ellis, G.F. Gerberick, P. Griem, P.M. McNamee, C.A. Ryan and B. Safford (2006). Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. The Toxicologist, 90(1):465.

5. A.M. Api and L.W. Smith (2003). Safety evaluations in the fragrance industry. The China International Conference Center for Science and Technology 5

th Congress of Toxicology

in Developing Countries, November 10-13, 2003.

6. A.M. Api and J. Cocchiara (2003). A dermal safety evaluation of cinnamic alcohol. The Toxicologist, 72(S-1), 301-302.

7. A.M. Api and D.A. Isola (2002). In vitro human skin penetration of the radiolabelled fragrance materials, AHTN and HHCB. The Toxicologist, 66(1-S), 164-165.

8. A.M. Api and C.S. Letizia (2001). Evaluation of the sensitization potential of hydroxycitronellal in an extended product use test. The Toxicologist, 60(1), 61.

9. A.M. Api (2000). Quenching of citral, cinnamaldehyde and phenylacetaldehyde sensitization in human repeated insult patch tests. Contact Dermatitis 42(2 Supplement), 40.

10. A.M. Api and D.A. Isola (2000). Quenching of citral sensitization demonstrated in a human repeated insult patch test. The Toxicologist 726, Toxicological Sciences, Supplement, 54(1):154.

11. A.M. Api and R.A. Ford (1999). Evaluation of the oral subchronic toxicity of AHTN and HHCB in the rat. The Toxicologist, 48(1S):322.

12. A.M. Api, E.A. Pfitzer and R.H.C. San (1996). Genotoxicity tests with 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (AHTN). The Toxicologist, 232. Fundamental Applied Toxicology, 30(1 part 2), Suppl.

13. A.M. Api (1995). In vitro assessment of phototoxicity. Research Institute for Fragrance Materials, Inc. Proceedings of the Seventh International Information Exchange, November 16-17, 1995, Lanaken, Belgium.

14. A.M. Api (1995). Genotoxicity studies with nitromusks. Research Institute for Fragrance Materials, Inc. Proceedings of the Seventh International Information Exchange, November 16-17, 1995, Lanaken, Belgium.

15. A.M. Api, R.A. Ford and R.H.C. San (1995). An evaluation of musk ketone in a battery of short-term genotoxicity tests. The Toxicologist, 15(1): 82.


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16. A.M. Api and R.A. Ford (1993). Safety investigation of 2-phenoxyethyl isobutyrate by dermal exposure. The Toxicologist, 13(1): 54.

17. A.M. Api (1992). Fragrances and the skin: Animal alternatives. Research Institute for Fragrance Materials, Inc. Proceedings of the Sixth International Information Exchange, November 19-20, 1992, Princeton, New Jersey, USA, pp 127-137.

18. A.M. Api and R.A. Ford (1992). The use of guinea pig and human sensitization testing to determine the potential for allergic contact sensitization of methyl 2-nonynoate. Journal Dermal Clinical Evaluation Society, 3(1): 57.

19. T.Atobe, M.Hirota, T.Ashikaga, A.M. Api and J.F.Lalko (2015). Verification of a skin sensitization assessment neural network model by fragrance materials. Society of Toxicology 54th Annual Meeting, March 22-26, 2015, San Diego, CA, USA. The Toxicologist, 144(1), 282.

20. S.P. Bhatia, V.T. Politano, and A.M. Api (2010). Genotoxicity tests conducted on a group of structurally related aldehydes. Society of Toxicology 49th Annual Meeting, March 7-11, 2010, Salt lake City, Utah, USA.

21. S.P. Bhatia, V.T. Politano and A.M. Api (2009). Battery of Genotoxicity Studies Conducted on Structurally Related Nitriles. Society of Toxicology 48th Annual Meeting, March 15-19, 2009, Baltimore, Maryland, USA. The Toxicologist, 108(1), 222.

22. S Bhatia, J Lalko, K.R. Brain, D.M. Green, and A.M. Api (2009). In-vitro human skin penetration of the fragrance material dimyrcetol. International Journal of Toxicology (formerly Journal of the American College of Toxicology), 28 (1), 44.

23. S.P.Bhatia, V.T.Politano, E.M.Lewis, A.M.Hoberman, M.S.Christian, R.M.Diener and A.M. Api (2008). Developmental toxicity of methyl dihydrojasmonate (MDJ) in rats.The Toxicologist, 102(1), 313.

24. S Bhatia, J Lalko, K.R. Brain, D.M. Green, and A.M. Api (2007). In-vitro human skin penetration of the fragrance material HMPCC. The Toxicologist, 96(1), 432.

25. S Bhatia, J Lalko, K.R. Brain, D.M. Green, and A.M. Api (2006). In-vitro human skin penetration of the fragrance material geranyl nitrile. The Toxicologist, 90(1):165.

26. J. Cocchiara, A.M. Api and D. Jacobson-Kram (2001). In vitro and in vivo evaluation of the genotoxic potential of three aldehydes used as fragrance ingredients. The Toxicologist, 60(1), 101-102.

27. J. Cocchiara and A.M. Api (2003). A dermal safety evaluation of para-(tert-butyl)-alpha methylhydrocinnamic aldehyde (BMHCA). The Toxicologist, 72(S-1), 301.

28. J. Cocchiara, D.A. Isola and A.M. Api (2002). Investigation of the sensitization potential of musk ketone using the guinea pig maximization test (GPMT). The Toxicologist, 66(1-S), 165.

29. R.J. Dearman, I. Kimber, A.M. Api and J. Lalko (2011). Changes in the level of expression and frequency of B220 positive lymphocytes may discriminate more accurately between contact allergen and skin irritants. British Toxicology Society.

30. R.A. Ford and A.M. Api (1990). An investigation of the potential for allergic contact sensitization of several oakmoss preparations. Contact Dermatitis, 23(4): 249.

31. R.A. Ford and A.M. Api (1993). Safety investigation of diphenyl ether by dermal exposure. The Toxicologist, 13(1): 55.


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32. R.A. Ford, A.M. Api and D.R. Hawkins (1987). Absorption, distribution and excretion of topical doses of 14C-phenylethyl alcohol (PEA). The Toxicologist, 7(1): 237.

33. R.A. Ford, A.M. Api and A.K. Palmer (1987). The effect of phenylethyl alcohol applied dermally to pregnant rats. The Toxicologist, 7(1): 175.

34. R.A. Ford, D.R. Hawkins, R. Schwarzenbach and A.M. Api (1999). Human Systemic exposure after dermal absorption of AHTN and HHCB as used in fragrances-evidence for lack of absorption from a skin reservoir. The Toxicologist 48 (1S):73.

35. D.A. Isola and A.M. Api (2001). The effects of vehicles and concentration on the dermal irritation potential of five allyl esters. The Toxicologist, 60(1), 61.

36. L. Jones, R. Foxenberg, J. Lalko, C.S. Letizia, and A.M. Api (2008). Sensitization Potential of Vetiveryl Acetate Evaluated Using the Local Lymph Node Assay. The Toxicologist, 102(1), 298.

37. R.A. Kemper, D.L. Nabb, S.A. Gannon, T.A. Snow and A.M. Api (2005). Metabolism of geranyl nitrile and citronellyl nitrile by primary hepatocytes from mice, rats and humans. The Toxicologist, 84(S-1), 322.

38. S.Khan, I. Kimber, R.J. Dearman, J.F. Lalko and A.M. Api (2011). Allergen Exposure Results in Changes in the Level of Expression and Frequency of B220+ Lymphocytes. The Toxicologist, 120(Suppl. 2): 18-19.

39. J. Lalko, R.J. Safford, D.W. Roberts, A.M. Api, (2015). The Dermal Sensitization Threshold (DST) for Chemicals Classified as Protein Reactive. Society of Toxicology 54th Annual Meeting, March 22-26, 2015, San Diego, CA, USA. The Toxicologist, 144(1), 272.

40. J.F.Lalko, A.M. Api, (2014). In vitro skin sensitization methods: Evaluating the available datasets. 9th World Congress on Alternatives to Animal Testing in the Life Sciences. August 24-28, 2014, Prague, CZ

41. J.F.Lalko, A.M. Api, (2014). Vetiveryl Acetate Evaluated for Potential Phototoxicity Utilizing a Human Epidermal Model and Patch Testing. Society of Toxicology 53rd Annual Meeting, March 23-27, 2014, Phoenix, AZ, USA. The Toxicologist, 138(1), 567.

42. J. Lalko, I. Kimber, R.J. Dearman, F. Gerberick, A.M. Api and L.W.Smith (2011). Preferential Reactivity of Contact and Respiratory Low Molecular Weight Chemical Allergens under Competitive Conditions. The Toxicologist, 120(Suppl. 2): 18.

43. J. Lalko and A.M. Api (2010). Peptide reactivity profiles of reference contact and respiratory low molecular weight chemical allergens. Society of Toxicology 49th Annual Meeting, March 7-11, 2010, Salt lake City, Utah, USA. The Toxicologist, 114(1), 67.

44. J. Lalko, I. Kimber, R.J. Dearman, G.F. Gerberick, and A.M. Api (2009). Examination of Potential Chemical Interactions in Skin Sensitization: Activity of Clove Bud Oil Admixed with Oxazolone in the Local Lymph Node Assay. Society of Toxicology 48th Annual Meeting, March 15-19, 2009, Baltimore, Maryland, USA. The Toxicologist, 108(1), 314.

45. J. Lalko, K.R. Brain, D.M. Green and A.M Api (2008). In-Vitro Human Skin Penetration of the Fragrance Material Linalool. The Toxicologist, 102(1), 319.

46. J. Lalko, K.R. Brain, D.M. Green and A.M Api. Skin Penetration of the Fragrance Material Linalool. International Journal of Toxicology, 26(6):608.

47. J. Lalko, R. J. Dearman, L. Beresford, C. J. Betts, A. M. Api and I. Kimber (2006). Experience with EtOH:DEP as an alternative vehicle for the Local Lymph Node Assay The 27th Annual Meeting of the American College of Toxicology – November 5-8, 2006.


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48. J. Lalko and A. M. Api (2006). Investigation of the relationship between induction and elicitation thresholds for contact allergy. The Toxicologist, 90(1):464-465.

49. J. Lalko, R. J. Dearman, L. Beresford, C. J. Betts, A. M. Api and I. Kimber (2006). Experience with EtOH:DEP as an Alternative Vehicle for the Local Lymph Node Assay The 27th Annual Meeting of the American College of Toxicology – November 5-8, 2006

50. J. Lalko and A. M. Api (2005). Potency estimations for several fragrance materials in the local lymph node assay and their correlation to human studies. The Toxicologist, 84(S-1), 86.

51. A. Lapcynski, D A Isola and A M Api (2005). Subchronic toxicity of α-methyl-1,3-benzodioxole-5-propionaldehyde in rats. The Toxicologist, 84(S-1), 93.

52. C.S. Letizia, V.T. Politano, and A.M. Api (2010). An in vivo mouse micronucleus test with gamma-nonalactone. Society of Toxicology 49th Annual Meeting, March 7-11, 2010, Salt lake City, Utah, USA. The Toxicologist, 114(1), 237.

53. C.S. Letizia, V.T. Politano, and A.M. Api (2009). Subchronic Toxicity of Citronellyl Nitrile in Rats. Society of Toxicology 48th Annual Meeting, March 15-19, 2009, Baltimore, Maryland, USA. The Toxicologist, 108(1), 105.

54. C.S. Letizia, A.M. Api, and V.T. Politano (2008). Subchronic Toxicity of Dimyrcetol in Rats. The Toxicologist, 102(1), 104.

55. C.Letizia, A.M.Api, V.T.Politano, E.M.Lewis, A.M.Hoberman, M.S.Christian and R.M.Diener (2007). Evaluation of the developmental toxicity of linalool in rats. The Toxicologist, 96(1), 92.

56. C. S. Letizia, A. M. Api, E. M .Lewis, A. M. Hoberman, M. S. Christian and R. M. Diener (2006). Evaluation of the developmental toxicity of alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde in rats. The Toxicologist, 90(1):190.

57. C S Letizia, D A Isola and A M Api (2005). Subchronic toxicity of acetyl cedrene in rats. The Toxicologist, 84(S-1), 94.

58. C.S.Letizia, J.Cocchiara, D.A.Isola and A.M.Api (2004). Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone. The Toxicologist, 78(S-1), 37.

59. C.S. Letizia and A.M. Api (2003). Evaluation of the phototoxic and photoallergenic potential of methyl n-methyl anthranilate. The Toxicologist, 72(S1), 378-379.

60. C.S. Letizia and A.M. Api (2002). alpha-Amylcinnamaldehyde (alpha-ACA) and alpha-hexylcinnamaldehyde (alpha-HCA) do not produce dermal sensitization or cross-sensitization in humans. The Toxicologist, 66(1-S), 163-164.

61. C.S. Letizia and A.M. Api (2001). Update on the dermal sensitization potential of hydroxycitronellal used in fragrances. The Toxicologist, 60(1), 61.

62. C.S. Letizia and A.M. Api (2000). A dermal safety evaluation of extracts from Tagetes plants used in fragrances. The Toxicologist 1863, Toxicological Sciences, Supplement, 54(1):397.

63. D. McGinty, V.T. Politano, and A.M. Api (2010). Evaluation of isoamyl alcohol in an in vivo mouse micronucleus test. Society of Toxicology 49th Annual Meeting, March 7-11, 2010, Salt lake City, Utah, USA. The Toxicologist, 114(1), 237.


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64. D. McGinty, V. T. Politano, A.M. Api (2009). The Photoclastogenicity of Furocoumarins: Bergamottin and Isopimpinellin. Society of Toxicology 48th Annual Meeting, March 15-19, 2009, Baltimore, Maryland, USA. The Toxicologist, 108(1), 224.

65. D. McGinty, V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener, and A.M. Api (2008). Oral (Gavage) Developmental Toxicity of 4-Tertbutylcyclohexyl Acetate (4-tBCHA) in Rats. The Toxicologist, 102(1), 314.

66. D. McGinty, A.M. Api and V.T. Politano (2007). Evaluation of alpha-ionone in an in vivo mouse micronucleus test. The Toxicologist, 96(1), 347.

67. E.A. Pfitzer, A.M. Api, and R.H.C. San (1996). Genotoxicity tests with 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-?-2-benzopyran (HHCB). The Toxicologist, 233. Fundamental Applied Toxicology, 30(1 part 2, Suppl.).

68. V.T. Politano, E.M. Lewis, A.M. Hoberman, R.M. Diener, and A.M. Api (2015). Evaluation of the developmental toxicity of methyl anthranilate. Society of Toxicology 54th Annual Meeting, March 22-26, 2015, San Diego, CA, USA. The Toxicologist, 144(1), 367.

69. V.T. Politano and A. M. Api (2014). Evaluation of the Subchronic Toxicity of Acetoxydihydrodicyclopentadiene. Society of Toxicology 53rd Annual Meeting, March 23-27, 2014, Phoenix, AZ, USA. The Toxicologist, 138(1), 417.

70. V.T.Politano, E.M.Lewis, A.M.Hoberman, R.M.Diener and A.M. Api (2013). One-generation reproduction study of isobornyl acetate in rats, with an evaluation through sexual maturity in the F1 generation. Society of Toxicology 52st Annual Meeting, March 10-14, 2013, San Antonio, TX, USA. The Toxicologist, 132(1), 449.

71. V.T. Politano, E.M. Lewis, A.M. Hoberman, R.M. Diener and A.M. Api (2012). Evaluation of the reproductive toxicity of alpha-hexyl cinnamic aldehyde. Society of Toxicology 51st Annual Meeting, March 11-15, 2012, San Francisco, CA, USA. The Toxicologist, 126(1), 516.

72. V.T. Politano, E.M. Lewis, A.M. Hoberman, R.M. Diener and A.M. Api (2011). Evaluation of A Combined Dermal Developmental And Perinatal/Postnatal Reproduction Toxicity Study Of PEA (Phenethyl Alcohol) In Rats - Including An Examination Skeletal Variants Postnatally. The Toxicologist, 120(Suppl. 2): 221.

73. V.T. Politano and A.M. Api (2010). Treatment of lactating dams with HMPCC causes reversible skin peeling in rat offspring. The Toxicologist, 114(1), 87.

74. V.T.Politano, J.Scognamiglio, E.M.Lewis, A.M.Hoberman, M.S.Christian, R.M.Diener and A.M.Api (2009). Percutaneous uterotrophic assay of lavender oil in immature female rats. The Toxicologist, 108(1), 301.

75. V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener, and A.M. Api (2008). Developmental Toxicity of Dimyrcetol in Rats. The Toxicologist, 102(1), 313.

76. V.T.Politano and A.M.Api (2007). Evaluation of 4-(4-hydroxy-4-methypentyl)-3-cyclohexen-1-carboxaldehyde (HMPCC) in a 28 day oral subchronic toxicity study. The Toxicologist, 96(1), 313.

77. V.T. Politano, E.M. Lewis, A.M. Hoberman, M.S. Christian, R.M. Diener and A.M. Api (2006). Evaluation of the developmental toxicity of alpha-iso-methylionone in rats. The Toxicologist, 90(1):191.

78. J. Potter, R.L. Smith and A.M. Api (2000). An assessment of the release of inorganic cyanide from the fragrance materials, benzyl cyanide, geranyl nitrile and citronellyl nitrile applied dermally to the rat. Toxicology Letters, 116(Suppl. 1):23.


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79. J. Potter, R.L. Smith and A.M. Api (2000). Urinary thiocyanate levels as biomarker for the generation of inorganic cyanide from benzyl cyanide in the rat. Toxicology Letters, 116(Suppl. 1):75.

80. D.L. Putman, R.A. Ford, A.M. Api, C.A. Bigger, R.H.C. San and D. Jacobson-Kram (1993). An evaluation of musk xylene in a battery of short-term genotoxicity tests. The Toxicologist, 13(1): 222.

81. G. Ritacco, V.T. Politano, J. Lalko, and A.M. Api (2015). Phototoxicity of ethyl maltol in hairless mice. Society of Toxicology 54th Annual Meeting, March 22-26, 2015, San Diego, CA, USA. The Toxicologist, 144(1), 269.

82. G. Ritacco, V.T. Politano, and A.M. Api (2014). Lauric aldehyde: ninety-day repeated-dose oral (dietary) toxicity in rats. Society of Toxicology 53rd Annual Meeting, March 23-27, 2014, Phoenix, AZ, USA. The Toxicologist, 138(1), 418.

83. J. Scognamiglio, V. Politano, and A.M. Api (2013). Evaluation of the results of several genotoxicity tests in carvacrol and thymol. Society of Toxicology 52st Annual Meeting, March 10-14, 2013, San Antonio, TX, USA. The Toxicologist, 132(1), 319.

84. J. Scognamiglio, D. McGinty, V.T. Politano, and A.M. Api (2011). Oral (Gavage) One-Generation Reproduction Study of Citronellyl Nitrile in Rats, With An Evaluation Through Sexual Maturity in the F1 Generation. The Toxicologist, 120(Suppl. 2): 335.

85. J. Scognamiglio, V.T. Politano, and A.M. Api (2010). Evaluation of l-menthone in an in vivo mouse micronucleus test. Society of Toxicology 49th Annual Meeting, March 7-11, 2010, Salt lake City, Utah, USA. The Toxicologist, 114(1), 237.

86. B. A. Wall, V. T. Politano and A.M. Api (2015). An in vivo mouse micronucleus test with o-methoxy cinnamaldehyde. Society of Toxicology 54th Annual Meeting, March 22-26, 2015, San Diego, CA, USA. The Toxicologist, 144(1), 225.

Summary of Experience Research Institute for Fragrance ... · Research Institute for Fragrance...

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