Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants
description
Transcript of Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants
![Page 1: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/1.jpg)
Sugar FurrAcc 142056
Enzootic Nasal
Adenocarcinoma of
Small Ruminants
Trisha OuraFebruary 28, 2011
![Page 2: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/2.jpg)
Sugar Furr
• < 2yo F Suffolk Sheep• Unilateral nasal
discharge• Swelling on head (left
dorsal)– Fluctuant, “reducible”
![Page 3: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/3.jpg)
Radiographs
![Page 4: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/4.jpg)
• Left nasal mass with frontal sinus obstruction or extension
• DDX: cyst, hematoma, abscess, granuloma, neoplasia
Echogenic fluid (aspirated)
Minimally vascular, echogenic mass
Ultrasound
![Page 5: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/5.jpg)
Neoplasia
• Enzootic Nasal Adenocarcinoma of Small Ruminants– Rare (few case reports/case series in literature)– Sheep > goats– Young (e.g. 2-4yo), M=F– Upper respiratory signs (stridor, mouth breath), nasal discharge,
head shaking, sneezing– Facial asymmetry, exophthalmos– Occasionally with concurrent inflammatory polyps in nasal cavity– Can have concurrent pneumonia– DDX: Oestrus ovis myiasis
![Page 6: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/6.jpg)
Enzootic Nasal Adenocarcinoma (ENA)aka: infectious adenopapillomatosis, infectious adenopapilloma, infectious adenocarcinoma
• Bilateral or unilateral• Can invade sinuses/adjacent bony
structures– Usually arises from ethmoid mucosa
• Rarely metastasize• Death due to anorexia, weight loss• Retroviral etiology
– Similar to Jaagsiekte virus• ovine pulmonary carcinoma
– Both are contagious tumors of respiratory epithelium, low grade malignancy
![Page 7: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/7.jpg)
ENA
• Transmission:– Experimental intranasal innoculation
• Prevalence:– US, Canada, Europe (Spain, Italy), Japan, China, India,
Africa– No breed predisposition– Cases can be clustered in certain flocks/herds
• FYI: other ovine/caprine retroviruses:– Maedi-Visna (ovine progressive pneumonia), caprine
arthritis encephalitis
![Page 8: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/8.jpg)
Gross Lesions
![Page 9: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/9.jpg)
Further Diagnostics
• PCR• Immunohistochemistry
• Electron microscopy
Sugar Not Sugar
![Page 10: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/10.jpg)
Treatment
• Surgical removal– Can be very bloody! Prepare for transfusion
• Many die within 3 months after diagnosis
![Page 11: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/11.jpg)
Sugar
• IHC positive on biopsy and aspirated fluid• EM was less rewarding – hard to differentiate from cilia
• PCR is pending…
![Page 12: Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants](https://reader033.fdocuments.in/reader033/viewer/2022061612/5681668c550346895dda55bb/html5/thumbnails/12.jpg)
References• De Las Heras M, et al. Pathology of enzootic intranasal tumor in thirty-
eight goats. Vet Pathol. 1991;28:474-481.• McKinnon AO, et al. Enzootic nasal adenocarcinoma of sheep in Canada.
Can Vet J. 1982;23:88-94.• Martini JC, DF York. Retrovirus-associated neoplasms of the respiratory
system of sheep and goats. Vet Clin North Am Food Anim Pract. 1997;13:55-70.
• Pugh DG. Upper Respiratory Diseases in Sheep and goat medicine. 2002. Elsevier.
• Svara T, et al. Enzootic nasal adenocarcinoma of sheep in Slovenia. J Vet Med. 2006;53:26-29.
• Yi G, et al. Descriptive study of enzootic nasal adenocarcinoma in goats in southwestern China. Trans Emerg Diseases. 2010;57:197-200.