Suffering from Osteoporosis?-Mathematical modeling of bone

remodeling at cellular level

Yanan Wang31/10/2007

Osteoporosis

How does osteoporosis relate to my work (bone remodeling)?

Bone remodeling cycle at cellular level

Bone remodeling (Coupling)

Significance of bone remodeling

Serving to adjust bone architecture.

Helping to repair microdamage.

Maintaing plasma calcium homeostastis.

Logical structure of the model

Reasons for including PTH

PTH is currently involved in clinical trials.

PTH 1-34 was recently approved by the Food and Drug Administration of America (FDA).

Intermittent vs Continuous

Biomechanical control of bone remodeling

Effect of electromagnetic field on remodeling

Conclusion

The end

Thank you