SUBJECT INDEX ABSORPTION (1) ACIDOSIS...
Transcript of SUBJECT INDEX ABSORPTION (1) ACIDOSIS...
ABS -ADR
(7)ABSORPTION (1) ACIDOSIS
adrenocortical hormones 8453 central nervous system 8493
anionic agents 8495 C02 inhalation 8493
benzomethamine 8494 drug accumulation 8493
8495 drug penetration 8493
fasted rats 8494 hypercapnia 8493
gastrointestinal tract
omega-haloalkylamines
8454
8496
ACTH (8)
methadone-2-.C14 absorption 8453
intestinal loops 8494 ADRENAL MEDULLA (9)
8496 catecholamine release 8497
intraluminal environment 8495 CC14 hepatotoxicity 8497
male rats 8453 depot fat 84978496
methadone�-2-C14 8453
free fatty acid release
hepatic vasoconstriction
8497
8497
nitrofurantoin 8454 histamine pressor response 8458
organic cations 8495 sympathin release 8458
pH changes 8495 ADRENALECTOMY (10)
pituitary hormone 8453 cardiac phosphorylase
quaternary analogues 8496 activity 8468
small intestine 8494 CC14 hepatotoxicity 8497
8495 8496 cortisone maintenance 8453
unfasted rats 8494 histamine pressor response 8458
8495 methadone absorption 8453
urinary bladder 8454 potassium concentrations 8456
ACETANILID (2) protective action 8497deoxycholate 8449 renal tubular function 8456
liver damage 8449 sodium chloride maintenance 8453
metabolism 8449 sodium concentrations 8456
ACETAZOLAHIDE (3) stop-flow analysis 8456
carbonic anhydrase inhibition 8488 ADRENERGIC BLOCKADE (11)
noncompetitive mechanism
ACETAZOLAMIDE-S35 (4)
8488 cation exchanges
contracting muscle
8471
8471
brain levels 8493 dibenamine 8471
respiratory acidosis 8493 dibenzylene 8471
respiratory alkalosis 8493 phentolamine 8471
selected areas 8493 piperoxan 8471
ACETYLCHOLINE (5) work performance 8471
cerebroside sulfate 8450 ADRENERGIC BLOCKING AGENTS (12)
ganglionic transmission 8480 Cd4 hepatotoxicity 8497
lipid soluble complex 8450 ergotamine tartrate 8497
MAO inhibitors 8480 phenoxybenzamine 8497
stiniulatory action 8480 protective action 8497
ACETYLDIGITOXIN (6) ADRENOCORTICAL HOR1�NES (13)
anti-adrenergic action 8477 methadone absorption 8453
A-V refractory period 8477 methadone disposition 8453
epinephrine chronotropic ADRENOCORTICAL STEROIDS (14)
response 8476 biological potency 8491
heart rate 8476 congeners 8457
pacemaker reactivity 8476 dose-response curves 8457
postganglionic sympathetic 9 alpha-fluorocortisol
stimulation 8476 hemisuccinate 8457
1961
SUBJECT INDEX
S-l
ADR-ANP
hydrocortisone derivatives 8491 brain mitochondrial fractions 845014 alpha-hydroxy-S sodium cerebroside sulfate
succinate 8457 interactions 8450inotropic action 8457 guinea-pig ileum 8450
papillary muscles 8457 histamine response 8450
radioactivity excretion 8491 5-hydroxytryptamine 8450
spirolactone 8457 lipid soluble complexes 8450
structure action relationship 8457 norepinephrine 8450
tissue distribution
triamcinolone-H3
8491
8491
solubility reactions
AMINO ACIDS (22)
8450
AGE (15) L-.1-.ascites tumor cells 8473albino rats 8475 estradiol effect 8487
chemically-induced seizures 8475 glycine-2-C14 8473
potency ratios 8475 plasma levels 8487seizure patterns 8475 protein incorporation 8473
ALCOHOLS (16) rat uterus 8487
inhibitor activity 8469 reserpine effect 8473
liver homogenates 8469 AMINOPYRINE (23)
methanol oxidation 8469 deoxycholate 8449
ALKALOSIS (17) liver damage 8449
central nervous system 8493 metabolism 8449
drug accumulation 8493 8-ANINOTHEOPHYLLINE (24)
drug penetration 8493 blood pressure 8486
hyperventilation 8493 coronary blood flow 8486
hypocapnia 8493 diuretic effect 8486
ALKYLATING AGENTS (18) epinephrine pressor response 8486
anti-tumor effects 8473 hexamethonium pretreatment 8486
chlorambucil 8473 intraduodenal administration 8486
reserpine combination 8473 intravenous administration 8486
thio-TEPA 8473 oral administration 8486
tumor-bearing mice 8473 pharmacologic response 8486
ALVEOLAR AIR (19) sodium arsenate pretreatment 8486
chlorpromazine 8502 sodium salt 8486
controlled pCO� 8502 tolazoline 8486
human subjects 8502 toxicity 8486
meperidine 8502 3-’AMINO-l,2,4-TRIAZOLE (AT) (25)
respiratory effects 8502 blood methanol disappearance 8469
AMIDES, BENZILIC (20) hepatic catalase activity 8469
albino mice 8460 liver homogenates 8469
albino rats 8460 methanol metabolism in vitro 8469
anticonvulsant action 8460 AMIPHENAZOLE (26)
chemical assay 8460 grouped mice 8464
daily administration 8460 mortality 8464
N-substituted derivatives 8460 motor activity 8464
physiological disposition 8460 AMPHETAMINE (27)
structure action relationship 8460 denervated hind limb 8499
tissue concentrations 8460 deoxycholate 8449
toxicity 8460 grouped mice 8464
urinary excretion 8460 heart contractile force 8499
AMINES (21) liver damage 8449
acetylcholine 8450 metabolism 8449
SUBJECT INDEX
VOL. 131
S-2
(28)
(35)
(29)
(30)
metrazol seizure test
N-ethyl derivatives
pentylenetetrazol extensor
seizures
protective index
ANTIEMETIC AGENTS (36)
apomorphine-induced emesis
8502
8502
8501
8502
8502
8501
8501
8501
8502
8501
8504
8504
8504
8504
8504
8504
8504
8504
8504
8504
8504
8468
8468
8468
8468
8448
8474
8474
8460
8474
8460
8460
8460
8460
8474
8460
8466
8466
8466
8466
8459
8459
8453
8453
8453
8473
8473
8474
8474
8459
8459
8499
8499
8499
8499
8499
8499
8499
8499
8499
(37)
(38)
(39)
(40)
(41)
(42)
(31)
(32)
(33)
(34)
isoproterenol inhibition
methylphenidate
norepinephrine augmentation
rabbit aortic strips
tyramine suppression
ATROPINE (43)
8477 acetylcholine response 8481
8477 inhibitor activity 8481
isolated muscle preparations 8481
8448 nerve stimulation response 8481
8448 slow intravenous infusion 8481
8448 steady nerve block 8481
1961
SUBJECT INDEX
ANP-ATR
S -3
methylphenidate antagonism
mortality
motor activity
pressor effect
vasoconstrictor action
ANALGESIA
adrenocortical hormones
methadone absorption
ANALGESICS
alveolar pCO2 control
chiorpromazine interactions
dextroniorami de
human subjects
meperidine
morphine
placebo administration
relief measurement
respiratory depression
statistical analysis
ANAPHYLACTOID REACTIONS
2-brom-lysergic acid
diethylamide
chlorpromazine
edema formation
egg-white induced
Evans blue dye accumulation
phenelzine
polymyxin-Bprotective agents
pyrilamine pretreatment
rat tissues
re serpine
ANESTHESIA
cardiac phosphorylase
activity
ether
pentobarbital
sympathetic activity
ANIONIC AGENTS
butyric acid effect
intestinal absorption
intraluminal environment
pH changesphenolsul fonphthalein
ANTI -ADRENERGIC AGENTS
A-V refractory period
cardiac glycosides
ANTIBIOTICS
cell wall synthesis
E. coli
penicillin
8499 5. aureus
8464 ANTICONVULSANTS
8464 albino mice
8499 anti-reserpine effects
8499 benzilic amides
diphenylhydantoin
8453 electroshock threshold
8453 NES test
8495
8495
8495
84958495
fluphenazine
phenothi azines
relative potencies
ANTIHISTANINES
cyproheptadine
reference agents
ANTI -INFLANMATORY AGENTS
analgesia
corti sone
methadone absorption
ANTI -NEOPLASTIC AGENTS
reserpine
tumor-bearing mice
ANTI-RESERPINE ACTIONS
albino mice
centrally acting agents
ANTISEROTONINS
cyproheptadine
reference agents
AORTA, ISOLATED
amphe t amine
catechol influence
histamine
iproniazid influence
BAC -BLO
BACTERIA (44) lactic acid content 8471
cell wall synthesis 8448 methanol concentrations 8469
E. coli 8448 methanol disappearance rate 8469
penicillin
S. aureus
8448
8448
sodium tungstate
triamcinolone-H3
8469
BENZONETHAMINE (45) concentration 8491
amino acids 8495 BLOOD FLOW (51)
bile 8495 bradykinin 8500
bile salts 8495 femoral artery 8500
calcium chloride 8495 kallidin 8500
chondroitin sulfate 8495 peripheral vascular bed 8500
dose-absorption curves 8494 BLOOD PRESSURE (52)
experimental procedures 8494 acetylcholine response 8481
fatty acid facilitation 8495 8-aminotheophylline 8486
hyaluronic acid 8495 amphetamine 8499
intestinal absorption 8494 anesthetized cats 8458
8495 anesthetized dogs 8481
intraluminal environment 8495 8486
protamine 8495 anesthetized rats 8500
quaternary ammonium compound 8494 angiotensin response 8498
sodium metaphosphate 8495 atropine infusion 8481
sorbitol 8495 atropine pretreatment 8498
3 -BENZOYL-4-HYDROXY-6-METHOXY- bradykinin 8500
BENZENESULFONIC ACID (BsA)(46) central sciatic stimulation 8498
albino rats 8503 central vagal stimulation 8498
8-methoxypsoralen injection 8503 C-O pressor response 8498
protective effects 8503 cyproheptadine influence 8459
topical application 8503 depressor effect 8486
ultraviolet irradiation 8503 3 ,4dihydroxyphenylpyruvate 8492
BENZTHIAZIDE (47) dopa 8492
carbonic anhydrase inhibition 8488 dopamine 8492
1 -BENZYL-2-ETHYL-5-METHOXY- drug modification 8458
TRYPTAMINE (BAS) (48) epinephrine 8459
cyproheptadine comparison 8459 ganglionic blockade 8459
inhibitor activity 8459 guanethidine intravenously 8498
rat uterus 8459 HCS inhibitor effect 8492
serotonin pressor response 8459 histamine 8458
serotonin-induced contraction 8459 rn-hydroxyphenylpyruvate 8492
BLADDER (49) kallidin 8500
anesthetized dog 8481 methylphenidate 8499
atropine blocking action 8481 nerve stimulation response 8481
pelvic nerve stimulation 8481 norepinephrine 8459
BLOOD (50) norepinephrine i.v. infusion 8498
adrenergic blockade 8471 norepinephrine response 8498
3-amino-l,2,4-triazole 8469 phentolamine pretreatment 8498
ammonia levels 8470 pilocarpine 8458
contracting skeletal muscle 8471 pressor response 8458
ethanol 8469 8459 8498
glutamylhydrazine effect 8470 pyridoxine deficiency 8492
hydrazine effect 8470 reserpine pretreatment 8498
intravenous injection 8491 secondary rise 8458
SUBJECT INDEX
VOL. 131
S -4
8459
8458
8498
8498
8498
84928498
8464
8464
8464
8464
8500
8500
8504
8504
8493
8493
8493
8493
8493
8493
8493
(61)
(62)
(53)
(54)
(55)
meperidine
respiratory effects
(64) 8488
8488
84888488
8488
8488
(65)
8499
8498
8498
8499
8499
8498
8499
8499
1961
SUBJECT INDEX
BLO-CAS
S -5
serotonin
spinal cats
spinal cord section
TEA pretreatment
tyramine response
rn-tyramine
vagotomy
BODY TEMPERATURE
CNS stimulants
grouped mice
lethal effects
motor activity
BRADYKININ
assay procedures
kallidin comparison
BRAIN
amine interactions
cerebroside sulfate
guinea-pig ileum
lipid extracts
mitochondrial fractions
potassium-K42 binding
BRETYLIUM �-TOLUENESULFONATE(56)
cardiac phosphorylase
activity
isolated perfused rat heart
postganglionic sympathetic
blockade 8468
BRUCINE (57)
albino rats
convulsant effects
maturation influence
toxic effects
CAFFEINE (58)
anticonvul sant s
CNS stimulants
grouped mice
MAO inhibitors
mortality
motor activity
reserpine-.induced seizure
facilitation
tonic extensor seizures
CALCIUM (59)
kidney uptake
pilocarpine effect
submaxillary gland uptake
CAPILLARIES (60)
Evans blue dye accumulation 8504
permeability changes
tissue plasma volume
CARBON DIOXIDE
blood pH
central nervous system
drug accumulation
drug penetration
radioactivity measurements
respiratory acidosis
respiratory alkalosis
CARBON DIOXIDE TENSION
alveolar air
chlorpromazine
controlled pCO2
8502
8502
8502
8502
8502
8450 simultaneous administration 8502
8450 CARBON TETRACHLORIDE (63)
8450 adrenalectomy 8497
8450 adrenergic blocking agents 8497
8450 BSP retention 8490
8450 female rats 8497
hepatotoxicity 8497
hexobarbital sleeping time 8490
8468 liver function 8490
8468 liver hemodynamics 8497
microsomal enzyme activity 8490
microsomal-depressing agent 8490
phenobarbital-induced changes 849t)
8475 spinal transection 8497
8475 urethan-induced changes 8490
8475 CARBONIC ANHYDRASE INHIBITION
8475 acetazolamidebenzthiazide
catalyzed CO2 hydration
equilibration rates
8474 pH-stat
8474 reversibility
8464 CARDIOVASCULAR SYSTEM
8474 arterial tissue
8464 blood pressure
8464 8499guanethidine
8474 heart
8474 methylphenidate
peripheral effects
8485 peripheral vascular
8485 resistance
8485 vasoconstrictor responses
CASEIN (66)
hydrazine inhibition 8470
VOL. 131
(68)
(69)
8495
8495
8495
8448
8448
8448
8448
8448
8448
8464
8461
8474
8475
8461
8461
8463
8461
8464
8493
8463
8464
8464
8465
8465
8474
8462
8493
8461
8461
8463
8462
8493
8461
8462
8465
8475
8464
8465
8493
8461
8465
8493
8450
8450
8450
8450
8455
8455
8459
8459
8459
8459
8465
8493
8462
8464
8493
8493
8493
8493
8493
8475
8493
8474
8493
8463
8493
8493
8465
8474
8464
8462
8463
8493
8464
(71)
(72)
(73)
SUBJECT INDEX
S -6
CAS -CHL
methylhydrazine inhibition
peptic hydrolysis
CATIONS (67)
adrenergic blocking agents
contracting muscle in situplasma electrolytes
transfer movements
CATIONS, ORGANIC
benzomethamine
intestinal absorption
intraluminal environment
CELLS, BACTERIAL
basal structure synthesis
E. coli
isotopic precursor
incorporation
nucleic acidpenicillin influence
protein
S. aureus
special structure synthesis
wall structure
CENTRAL NERVOUS SYSTEM (70)
albino mice
albino rats
8475anti-reserpine effects
aspirin
autoradiograms
behavior responses
8465
body temperature
brain levels
brain regions
carbon dioxide effect
cat brain
cerebral blood flow
convul sant s
C.S.F. levels
d-desoxyephedrine
differential accumulation
discriminative behavior
drug distribution
drug penetration
escape performance
excitantsgrouped mice
5 -hydroxytryptophan
inappropriate responses
intravenous injections
isolated mice
8470 lethal toxicity
8470 levallorphan antagonism
lysergic acid diethylamide
8471 maturation influence
8471 medullary respiratory centers
8471 meperidine effect
8471 monkeys
morphine
8465
motor activity
myelination
nitrous oxygen: oxygen
8448 oral administration
8448 overt behavioral activity
pain tolerance
pentobarbital
pentylenetetrazol extensor
seizures
pigeon pecking-performance
plasma ratios
pontile apneustic center
8448 pontile pneumotaxic center
psychological tests
8474 quantitative measurement
8465 respiratory alkalosis
respiratory mechanism
8474 response rate
salicylates
seizure patternsstimulants
timing behavior
tissue binding
vagal reflexes
variable interval performance
vascularity
CEREBROSIDE SULFATE
amine interactions
at ropine
brain mitochondrial
fractions
guinea-pig ileum
CHLORIDE
renal excretion
serotoninCHLORPHENIRANINE
cyproheptadine comparison
egg-white induced edema
histamine-induced
bronchospasm
histamine-induced
vasodepres sion
inhibitor activity 8459 antiserotonin activity 8459
serotonin-induced edema 8459 epinephrine pressor response 8459
CHLORPROMAZINE (74) ganglionic blockade 8459
antiemetic activity 8466 norepinephrine pressor
controlled alveolar pCO2 8502 response 8459
cyproheptadine comparison 8459 reference agents 8459
deoxycholate 8449 SY-2l comparison 8459egg-white induced edema 8459 CYSTEINE (82)
fluphenazine comparison 8466 mercaptomerin pretreatment 8484
human subjects 8502 renal hemoglobin distribution 8484
inhibitor activity 8459
liver damage 8449
meperidine interaction 8502 N-DEMETHYLATION (83)
metabolism 8449 buffer concentration 8489
respiratory effects 8502 glucose 1-phosphate addition 8489
serotonin pressor response 8459 glucose 6-phosphate addition 8489
serotonin-induced edema 8459 isocitrate addition 8489
COCAINE (75) liver microsomes 8489
action mechanism 8483 meperidine 8489
dose-response curves 8483 starved rats 8489
nerve conduction block 8483 substrate concentration 8489
sodium concentration 8483 DEOXYCHOLATE, SODIUM (84)
CODEINE (76) drug metabolism 8449
deoxycholate 8449 inhibitor effect 8449
liver damage 8449 liver enzyme activities 8449
metabolism 8449 DESOXYCORTICOSTERONE (85)
CONTRACTION (77) inotropic action 8457
adrenergic blockade 8471 papillary muscle 8457
cation changes 8471 potassium concentrations 8456
skeletal muscle in situ 8471 renal tubular function 8456
CONTRACTION, HEART (78) sodium concentrations 8456
heart-lung preparation 8478 stop-flow analysis 8456
reserpine pretreatment 8478 DEXTROMORAMIDE (86)
sympathetic nerve stimulation 8478 chronic pain relief 8501
ventricular function curves 8478 morphine comparison 8501
CONVULSIONS (79) placebo administration 8501
albino rats 8475 side effects 8501
blood-CNS barrier 8475 statistical analysis 8501
brain amino acids 8475 H3-DIAMINOPIMELIC ACID (DAP)(87)
carbonic anhydrase activity 8475 E. coli incorporation 8448
chemically induced 8475 penicillin 8448
maturation effect 8475 DIGITALIS (88)
potency ratios 8475 extravagal factor 8477
CORTISONE (80) heart rate 8477
inotropic action 8457 peripheral inhibitor activity 8477
methadone metabolism
methadone-2-’C14 absorption
8453
8453
sympathetic nervous system
DICITOXIN (89)
8477
mineralocorticoid activity 8457 anti-adrenergic action 8477
papillary muscle 8457 A-V refractory period 8477
CYPROHEPTADINE (81) epinephrine chronotropic
antihistaminic activity 8459 response 8476
1961
SUBJECT INDEX
CHL-DIG
S -7
DIG-EPI
heart rate
pacemaker reactivity
postganglionic sympathetic
stimulation
3 , 4-DIHYDROXYPHENYLA.LANINE
(DOPA)
8476 nicotine
8476 nitrogen mustard
perphenazine effect
(90)
8476 veratrum viride
ENZYME INDUCTION (100)
hexobarbital sleeping time
phenobarbital
urethan
ENZYMES (101)
dopa decarboxylase in vivo 8492
HCS pretreatment 8492
pressor effect 8492
3 , 4-DIHYDROXYPHENYLPYRUVIC
ACID (3,4-DHPP) (91)
HCS pretreatment 8492
metabolism Ia !i:.Y.2 8492
pressor effect 8492
DIMERCAPROL (92)
mercaptomerin pretreatment 8484
renal hemoglobin distribution 8484
DIPHENHYDRAMINE (93)
cyproheptadine comparison 8459
histamine-induced
acetazolamine inhibition
AT inhibitor activity
benzthiazide inhibition
carbonic anhydrase
cardiac phosphorylase
activitycatalase activity
Cd4 hepatotoxicity
N-demethylating system
demethylation inhibitor
deoxycholate inhibition
8459 determination procedure
8459 drug metabolism
glutamic dehydrogenase
activity
magnesium ATP-ase activation
methanol metabolism
monoamine oxidase inhibition
obstructive jaundice
oxidative phosphorylation
perfused rat hearts
fasted hydrated rats
(94)
(95)
(96)
(97)
(98)
(99)
rat heart
serotonin metabolism in vivosuccinoxidase activity
sympathetic activity
tryptamine metabolism in vivo
tungstate inhibitor activity
xanthine oxidase activity
EPINEPHRINE (102)
dose-response curves
intravenous infusion
methylphenidate potentiation
SUBJECT INDEX
VOL. 131
S -8
bronchospasm
inhibitor activity
D lURE S IS
anesthetized rats
bradykinin
kallidin
urine flow
DIURESIS , MERCURIAL
hemoglobin concentration
rat kidney
renal cortex
renal medulla
DIURETICS, XANTHINE
comparative effects
etherized dogs
fasted dehydrated rats
EDEMA , ANAPHYLACTOID
cyproheptadine antagonism
egg white induced
serotonin induced
ELECTROLYTES
renal excretion
serotonin
tubular reabsorption
EMESIS, DRUG INDUCED
apomorphi ne
fluphenazine effect
lanatoside-C
8500
8500
8500
8500
8484
8484
8484
8484
8486
8486
8486
8486
8459
8459
8459
8455
8455
8455
8466
8466
8466
liver damage
liver function
liver microsomes
8489
phosphorylase activity
rat liver homogenates
acetyldigitoxin effect
A-V nodal reactivity
basal cardiac frequency
digitoxin effect
8466
8466
8466
8466
8490
8490
8490
8488
8469
8488
8488
8468
8469
8497
8489
8489
8449
8467
8449
8497
8449
8497
8449
8497
8469
8452
8449
8497
8467
8467
8469
8468
8452
8497
8468
8452
8469
8469
8476
8476
8476
8476
8476
8476
8499
positive chronotropic effect 8476
(103)
(104)
(105)
EPI-GLY
8495
8495
8495
8495
(112)
8466
8466
8466
8466
8468
8459
8458
(114)
(115)
(116)
(117)
(118)
8460
8460
8460
8460
8460
8460
8460
8460
8460
8504
85048504
8504
8504
8504
8504
8504
8504
8472
8472
8472
8472
8454
8454
8448
84488448
8448
8448
8470
8470
8470
8470
8470
8470
8470
8470
8476
84778495 anti-adrenergic action
SUBJECT INDEX
S -9
1961
positive inotropic action
S-A nodal reactivity
ERGOTAMINE TARTRATE
CC14 hepatotoxicity
protective action
ESCHERICHIA COLI
cell wall synthesis
penicillin
ESTRADIOL
free amino acids
rat uterus
ESTROGENS (106)
benzomethamine absorption
8499 butyric acid
8476 propionic acid
small intestine
8497 FLUPHENAZINE (PROLIXIN)8497 antiemetic activity
drug-induced emesis
8448 pentobarbital-induced
8448 depression
phenothiazine comparisons
8487
8487
free amino acids 8487
rat uterus 8487
ETHANOL (107)blood methanol disappearance 8469
inhibitor activity 8469
methanol metabolism in vitro 8469
ETHIONINE (108)
administration routes 8490
BSP retention 8490
hexobarbital sleeping time 8490
liver function 8490
microsomal depressing agent 8490
microsomal enzyme activity 8490
phenobarbital-induced changes 8490
urethan-induced changes 8490
N-ETHYL-BENZILIC-A.MIDE (109)
anticonvulsant activity
metabolic biotransformation
N-dealkylation
neurological deficit
physiological disposition
protective index
stimulant component
tolerance
toxicity
EVANS BLUE (110)
experimental inflammation
phenel zine
quantitative measurement
recovery experiments
serotonin antagonists
tissue concentrations
tissue plasma volume
tissue space
total plasma volume
FATTY ACIDS (111)
acetic acid
GANGLIONIC BLOCKADE (113)
cardiac phosphorylase
activity
cryptoheptadine effect
hexamet honi um
8468
histamine pressor response 8458
pilocarpine pressor response 8458
serotonin pressor responses 8459
8458tetramethylarnmonium
GANGRENE
mouse tail
reserpine effect
subcutaneous injection
thiopental induced
GASTROINTESTINAL SYSTEM
isolated segments
nitrofurantoin absorption
GENTIAN VIOLET
cell wall synthesis
E. coli
S. aureus
GLUCOSE -C14
E. coli incorporation
penicillin
L-Gamma -GLUTAMYLHYDRAZINE
blood ammonia levels
enzymatic synthesis
fatty liver production
gamma-glutamyl transferase
activity
hydrazine metabolism
hydrolysis rate
spinal fluid ammonia
urinary hydrazino compounds
GLYCOSIDES, CARDIAC (119)
adrenergic cardiac
acceleration
GLY-HEMSUBJECT INDEX
VOL. 131
S-lO
A-V refractory period
direct effect
inhibitor activity
vagal action
GUANETHIDINE (120)
action mechanism
anesthetized dogs
blood pressure
cardiovascular effects
catecholamine release
chronic oral administration
intravenous administration
peripheral vascular
resi stance
reserpine-like effects
sympathetic blocking activity
vascular sympathetic
effectors
Ome�a-HAL0ALKYLANINES (121)
cyclization rates
intestinal absorption
male rats
nictitating membrane
quaternary analogues
unanesthetized dog
urinary excretion
HARNINE (122)
ganglionic blocking action 8480
reversible activity 8480
HEART (123)
accelerator nerve stimulation
acetyldi gi toxin
adrenal ligation
amphetamine response
A-V refractory period
bretylium
cardiac rate
contractile force
8499denervation
epinephrine infusion
epinephrine response
hexamethoni um
intact rat heart
methylphenidate influence
norepinephrine response
open-chest dogs
8499
8477 perfused isolated rat heart 8468
8477 phosphorylase a activity 8468
8476 rate changes 8477
8477 sympathetic activity 8468
thoracic sympathectomy 8477
8498 vagotomy 8477
8498 8499
8498 HEART AURICLES (124)
8498 isolated rabbit atria 8479
8498 microelectrode technique 8479
8498 quinidine effect 8479
8498 single cell records 8479
sodium lactate reversal 8479
8498 HEART, ISOLATED (125)
8498 AMP content 8467
8498 1-epinephrine 8467
freezing procedure 8467
8498 isometric systolic tension 8467
perfused rat heart 8467
phosphate determinations 8467
phosphorylase a activity 8467
resin treatment 8467
8496 tissue extracts 8467
8496 total phosphorylase activity 8467
8496 HEART MUSCLE (126)
8496 heart-lung preparation 8478
8496 myocardial contractility 8478
8496 pentobarbitalized dogs 8478
8496 reserpine pretreatment 8478
sympathetic nerve stimulation 8478
ventricular function curves 8478
HEART MUSCLE, ISOLATED (127)
adrenocortical steroids 8457
8477 cat papillary muscle 8457
8477 inotropic effect 8457
8477 structure action relationship 8457
8499 HEART RATE (128)
8477 anesthetized dogs 8476
8468 basal frequency 8476
8468 cardiac glycosides 8476
8468 denervated preparation 8476
epinephrine-induced
8477 acceleration 8476
8477 pacemaker reactivity 8476
8499 sympathetic nerve stimulation 8476
8468 HEMOGLOBIN (129)
8468 chlorothiazide 8484
8499 �-hydroxymercuribenzoate 8484
8499 kidney distribution 8484
8477 mercurial diuretics 8484
water diuresis 8484
HEXAJIETHONIUN
cardiac phosphorylase
activity
ganglionic blockade
isolated perfused rat heart
HEXOBARBITAL (131)
adult rabbits
deoxycholate
liver damage
obstructive jaundice
sleeping time
HEXOBARBITAL HYPNOSIS (132)
action modificationalbino mice
biotransformation rate
CC14 influence
ethionine influence
liver microsomal enzymes
phenobarbital -induced
shortening
sleeping time
urethan-induced shortening
HISTAMINE (133)
adrenalectotny
anesthetized cats
cerebroside sulfate
chlorpheniramine antagonism
cyproheptadine antagonism
ganglionic receptors
ganglionic stimulant action
hexamethonium pretreatment
lipid soluble complex
methadone
morphine
nicotine
pressor response
reserpine pretreatment
spinal catsTEA
TMA
tyramine comparison
vasodepressor effect
HISTAMINE LIBERATION (134)
compound 48/80
methadone absorption
HYDRAZINE
blood ammonia values
fatty liver production
glutamylhydrazine injection
peptic hydrolysis inhibition
urinary excretion
8470
8470
8470
8470
8470
8504
8504
8504
1961
SUBJECT INDEX
HEX-INF
5-11
(130) HYDROCORTISONE-4-C14 (136)
hydrocortisone derivatives 8491
8468 intravenous injection 8491
8468 metabolism in vitro 8491
8468 plasma half-lives 8491
tissue distribution 8491
8449 urinary excretion 8491
8449 HYDROXINDASOL (137)
8449 cyproheptadine comparison 8459
8449 egg-white induced edema 8459
8449 inhibitor activity 8459
rat uterus 8459
8490 serotonin pressor response 8459
8490 serotonin-induced contraction 8459
8490 serotonin-induced edema 8459
8490 5 -(3 -HYDROXYCINNAMOYL)
8490 SALICYLIC ACID (HCS) (138)
8490 blood pressure 8492
dopa decarboxylase inhibitor 8492
8490 hydroxyphenylpyruvic acid
8490 .&.a� 8492
8490 3-HYDROXYPHENYLPYRUVIC ACID
(3-HPP) (139)
8458 HCS pretreatment 8492
8458 metabolism in vivo 8492
8450 pressor effect 8492
8459 5-HYDROXYTRYPTAMINE (140)
8459 antagonists 8504
8458 cerebroside sulfate 8450
8458 electrolyte excretion 8455
8458 Evans blue dye accumulation 8504
8450 experimental inflammation 8504
8458 female dogs 8455
8458 lipid soluble complex 8450
8458 rat tissues 8504
8458 renal hemodynamics 8455
8458 water excretion 8455
8458 5-HYDROXYTRYPTOPHAN (141)
8458 behavioral effects 8462
8458 central nervous system 8462
8458 dose-response curves 8462
8459 intramuscular injections 8462
neurochemical correlates 8462
8453 pigeons 8462
8453 serotonin precursor 8462
(135)
INFLAMMATION , EXPERIMENTAL (142)
Evans blue dye accumulation
phenel zine
serotonin antagonists
8504 blood flow
(143) Ca45 uptake
male rats
mercurial diuretics
pilocarpine effect
renal hemodynamics
(144)
(145)
(146)
8495
8494
8495
8494
8494
8495
8495
8494
8494
8494
8495
8495
8494
8494
8495
8474
8480
8452
8485
8485
8484
8455
8485
8484
8484
8485
8484
8484
8485
8455
8455
8484
8484
8455
8456
8456
8456
8456
8456
8456
8456
8456
8456
8456
8456
8456
(151)
(152)
glutamylhydrazine injection
(148) hydrazine administration
84498449
8449
8449
8449
8500
8500
(154)
8461
mechanism 8461
8461
8461
(153)
8470
8470
8470
8449
8497
8497
8497
8449
8449
8497
8497
8497
8497
(149)
(150)
SUBJECT INDEX
VOL. 131
S-l2
INF-LIV
tissue plasma volume
INOTROPISM
adrenocortical steroids
papillary muscles
INTESTINE, ISOLATED
amine interactions
brain-lipid fractions
guinea-pig ileum
INTESTINE, SMALL
absorption .�:.!! :Y.tY.2
added intestinal mucus
anionic agents
benzmethamine absorption
dose effects
intestinal loops
intraluminal environment
loop preparations in vivolumen perfusion
mechanical manipulation
organic cations
pH changes
segment locations
unanesthetized rats
unfasted rats
IPRONIAZID
anti-reserpine effect
ganglionic blocking action
MAO inhibitor activity
pentylenetetrazol extensor
seizure
reserpine-induced ptosis
reserpine-induced seizure
facilitation
serotonin metabolism in vivotryptamine metabolism in vivo
ISONIAZID (147)
ganglionic transmission
JAUNDICE , OBSTRUCTIVE
adult rabbits
drug metabolism in vitro
hexobarbital sleeping time
liver damage
liver homogenates
KALLIDIN
assay procedures
bradykinin comparison
KIDNEY
acidifying salts
alkalinizing salts
8457 chlorothiazide
8457 electrolyte excretion
fractional distribution
8450 hemoglobin distribution
8450 �-hydroxymercuribenzoate
8450 K42 uptake
8474
8474
serotonin
urine flow
water diuresis
water excretion
KIDNEY TUBULAR FUNCTION
adrenalectomy
desoxycorticosterone
distal reabsorption
inulin concentrations
male rats
PAR concentrations
potassium concentrations
proximal reabsorption
sodium concentrations
stop-flow analysis
ureteral catheterization
urine flow
LEVALLORPHAN
8474 antagonist activity
8452 central respiratory
8452 meperidine effect
morphine effect
8480 LIVER
lipid content
LIVER DAMAGE
adult rabbits
biochemical events
carbon-tetrachloride induced
centrilobular necrosis
drug enzyme systems
drug metabolism
enzyme activity
fatty infiltration
8484 female rats
8484 histopathologic findings
8-methoxypsoralen injection 8503
obstructive jaundice
protective treatment
deoxycholate inhibition
8449 dopa decarboxylase inhibitors
8497 dopa formation
tissue homogenates
ultraviolet irradiation
LIVER MICROSOMES (155)
N-demethylating system
demethylation inhibitor
separated microsomes
starved rats
supernatant fraction
supplementation effect
tissue homogenates
LYSERGIC ACID DIETHYLAMIDE (156)
8449 dopamine formation
8503 enzymatic degradation
enzymatic N-demethylation
enzyme activity8489
8489
8489
8489
84898489
8489
8449
8492
8492
8492
8454
8489
8469
8470
8492
8449
j:�_gaflZfl��glut amylhydrazine
HCS pretreatment
hexobarbital sleeping time
8490
8470
8491
hydrazine
hydrocortisone derivatives
hydroxyphenylpyruvic acid
in vivo
liver damage
liver enzyme activities
liver homogenates
8469
cyproheptadine comparison 8459 8492
egg-white induced edema 8459 8449
inhibitor activity 8459 8449
rat uterus 8459 8449
serotonin pressor response 8459
serotonin-induced liver microsomal enzymes 8490
contractions 8459 liver microsomes 8489
serotonin-induced edema 8459 MAO inhibitors 8452
LYSINE-C14 (157) meperidine 8489
gentian violet 8448 methadone-2-C14 8453
penicillin
S. aureus incorporation
8448
8448
methanol
methocarbamol-C14
microsomal-depressing agents
8469
8451
8490
MEPERIDINE (158) microsomal-stimulating agents 8490
central respiratory mechanism 8461 nitrofurantoin 8454
chlorpromazine interaction 8502 obstructive jaundice 8449
controlled alveolar pCO2 8502 pithed cats 8492
N-demethylation 8489 pithed rats 8492
human subjects 8502 pituitary hormone 8453
levallorphan antagonism 8461 plasma half-lives 8491
liver microsomes 8489 pyridoxine deficiency 8492
respiratory effects 8502 serotonin 8452
starved rats 8489 starved rats 8489
MERCAPTOMERIN (159) studies in vivo 8452
cysteine 8484 tissue slices 8454
dimercaprol 8484 transamination reaction 8492
kidney weight 8484 triamcinolone 8491
renal cortical hemoglobin 8484 tryptamine 8452
renal medullary hemoglobin 8484 rn-tyramine formation 8492
METABOLISM, DRUG rn-tyrosine formation 8492
adrenocortical hormones 8453 urinary excretion 8451
adult rabbits 8449 8491
anesthetized dogs 8451 urine pH 8451
blood pressure responses 8492 urine volume 8451
cl4 recovery 8451 whole mouse 8452
chromogenous compounds 8451 METHADONE (161)
decarboxylation 8492 absorption 8453
(160)
1961
SUBJECT INDEX
LIV-MET
5-13
8453
8453
8453
8453
8453
8453
8464
8499
8499
(162)
(163)
8469
8469
8469
8469
8469
8469
8469
8469
8469
8469
8451
8451
8451
8451
8451
8451
8451
8451
8503
8503
8503
8503
8503
8503
8503
8503
8503
8503
8503
8503
8503
84998499
8499
8499
8464
8464
8471
8471
8471
8471
8471
8471
8471
8471
8471
8471
8471
8471
8471
8471
8459
8500
8500
8459
8459
8500
8500
(171)
MET-MUS
SUBJECT INDEX
VOL. 131
5-14
adrenocortical hormones
�14 labeled
metabolism
pituitary hormone
tissue distribution
urinary metabolites
METH.ANPHETAMINE
grouped mice
mortality
motor activity
METHANOL
alcohols
3-amino-l,2,4-triazole (AT)
blood concentration
catalase activity
competitive antagonists
ethanol antagonism
liver homogenates
peroxidative metabolism
sodium tungstate
xanthine oxidase activity
METHOCARBA�L (164)
C14 labeled
chromogenous metabolites
excretion
gastrointestinal absorption
human subjects
metabolism
placental transfer
tissue distribution
8 -METHOXYPSORALEN (165)
adrenalectomy
albino mice
albino rats
BSA pretreatment
experimental poisoning
hypophysectomy
liver damage
ovari ectomy
pathological changes
photosensitizing properties
pregnancy
toxicity
ultraviolet irradiation
METHYLPHENIDATE (166)
amine interactions
amphetamine antagonist
arterial tissue
cardiovascular system
grouped mice
mortality
motor activity
nictitating membrane
receptor mechanism
MONOAMINE OXIDASE (167)
inhibition 8452
serotonin metabolism in vivo 8452
tryptamine metabolism in vivo 8452
8464 MONOAMINE OXIDASE INHIBITORS
8464 albino mice (168) 8474
8464 anesthetized cat 8480
anti-reserpine effects 8474
ganglionic transmission 8480
iproniazid 8474
i sopropylhydrazine 8474
pentylenetetrazol extensor
seizures 8474
beta-phenylisopropylhydrazine 8474
MORPHINE (169)
central respiratory mechanism 8461
chronic pain relief 8501
dextromoramide comparison 8501
levallorphan antagonism 8461
placebo administration 8501
side effects 8501
statistical analysis 8501
MUSCLE, SKELETAL (170)
adrenergic blocking agents
blood lactic acid
cation changes
contraction amplitude
direct stimulation
indirect stimulation
intracellular potassium
content
intracellular sodium content
intracellular water content
plasma electrolytesrat gastrocnemius in siturat phrenic-nerve diaphragm
in vitro
stimulus duration
stimulus frequency
MUSCLE, SMOOTH
ACh-induced contractions
bradykinin
chicken rectal-cecumcyproheptadine antagonism
guinea pigs
guinea-pig ileum
histamine comparison
MUS -NOR
(178)
C1 72)
(173)
histamine-induced
bronchoconstriction
hydroxindasol antagonism
isolated intestine
kallidin
LSD antagonism
rabbit ileum
rat uterus
8500
reference agents
serotonin-inducedcontractions
MUSCLE SPINDLES
anesthetized cats
discharge frequency
ryanodine pretreatment
sensory endings
succinylcholine response
NARCOTICS
analgesic potency
chlorpromazine interactions
human subjects
meper i dine
respiratory depression
NERVE BLOCK (174)
action mechanism
action potentials
cocaine concentration
competitive antagonism
desheathed nerve trunk
frog sciatic-peroneal nerve
sodium concentration
NERVES (175)
acetylcholine response
atropine blocking action
intramuscular parasympathetic
endings
nerve-bladder strip
rabbit atria
rabbit ileum
sphincter pupillae
steady block
stimulation response
NEUROMUSCULAR JUNCTION (176)
adrenergic blocking agents
cationic exchanges
contracting skeletal muscle
in situ
NIALAMIDE (177)
ganglionic blocking action
(181)
8481
8481
8481
84818481
8481
8481
8471
8471
8463
8463
8463
8463
8463
8463
8463
8463
8463
8499
8499
8450
8499
8499
1961
SUBJECT INDEX
5-15
NICOTINE
8459 competitive phase 8458
8459 depolarization phase 8458
8500 ganglion cells 8458
8500 histamine pressor response 8458
8459 pilocarpine pressor response 8458
8500 NICTITATING MEMBRANE (179)
8459 acetylcholine perfusion 8480
amphetamine 8499
8459 contraction response 8480
dose-response curves 8499
8459 epinephrine response 8499
ganglionic ACh output 8480
8482 omega-haloalkylamines 8496
8482 MAO inhibitors 8480
8482 methylphenidate influence 8499
8482 norepinephrine response 8499
8482 phentolamine blocking action 8499
postganglionic stimulation 8480
preganglionic stimulation 8480
8502 relaxing effect 8496
8502 smooth muscle 8499
8502 tyramine response 8499
8502 unanesthetized animals 8496
8502 NITROFURANTOIN (180)
absorption 8454
8483 distribution 8454
8483 gastrointestinal tract 8454
8483 hepatectomy 8454
8483 metabolism in vitro 8454
8483 nephrectomy 8454
8483 plasma concentration 8454
8483 saliva concentration 8454
uretral ligation 8454
8481 urinary excretion 8454
8481 NITROUS OXIDE
accuracy
delayed response test
efficiency decrement
head movements
monkeysperseverative errors
premature responses
total responses
visual discrimination test
NOREPINEPHRINE (182)
blood pressure
catechol
8471 cerebroside sulfate
denervated hind limb
8480 iproniazid
PAIN (185)
(186)
VOL. 131
lipid soluble complex 8450 vagal effects 8481
methylphenidate 8499 PENICILLIN (189)
phentolamine blockade 8499 cell wall synthesis 8448
positive inotropic action 8499 E. coli 8448
S. aureus 8448
PENTYLENETETRAZOL (190)
OUABAIN (183) albino mice 8474
anti-adrenergic action 8477 anticonvulsants 8474
A-V refractory period 8477 CNS excitants 8474
inotropic action 8457 dopa influence 8474
papillary muscle 8457 dopamine influence 8474
OXYGEN CONSUMPTION (184) 5-NT influence 8474
reserpinized mice 8473 5-HTP influence 8474
tissue homogenates 8473 iproniazid pretreatment 8474
tissue slices 8473 isopropylhydrazine
DL-triiodothyronine 8473 pretreatment 8474
reserpine effect 8474
tonic extensor seizures 8474
albino rats 8465 PERIPHERAL RESISTANCE, VASCULAR
aspirin 8465 amphetamine (191)8499
behavioral technique 8465 8498
morphine 8465 8498
pentobarbital 8465 8498
salicylates 8465 8498
tolerance changes 8465
PAIN, CHRONIC
vasoconstriction 8499blood pressure 8501
dextromoramide 8501 femoral vascular bed 8499
dose response 8501 guanethidine intravenously 8498
experimental design 8501 intraarterial injections 8499
heart rate 8501 intravenous tyramine infusion 8498
hospital patients 8501 i.v. norepinephrine infusion 8498
morphine . 8501 methylphenidate 8499
placebo administration 8501 norepinephrine perfusion 8498
potency ratio 8501 norepinephrine-induced
pupil size 8501 vasoconstriction 8499
relief measurement 8501 perfusion pressure 8498
respiratory rate 8501 phentolamine blockade 8499
statistical analysis 8501 phentolamine perfusion 8498
PAPILLARY MUSCLES (187) reserpine pretreatment 8498
adrenocortical steroids 8457 serotonin perfusion 8498
inotropic effects 8457 sympathetic electrical
PARASYMPATHETIC NERVOUS SYSTEM stimulation 8498
ACh stimulatory response (188)8481 systemic pressure 8498
atropine blocking action 8481 tyramine perfusion 8498
bladder contractions 8481 vasoconstrictor responses 8498
blood pressure 8481 PERPHENAZINE (192)
isolated muscle preparations 8481 antiemetic activity 8466
nerve stimulation response 8481 fluphenazine comparison 8466
sensitivity threshold 8481 PHENALIDINE (193)
stomach contractions 8481 cyproheptadine comparison 8459
angiotensin perfusion
atropine
cholinergic receptors
denervated hindlimb
8499
epinephrine-induced
NOR-PHE
SUBJECT INDEX
S-16
8458
8458
8485
8485
8458
8458
8458
8458
8485
8458
8458
8485
flow 8485
8458
8458
8458
8458
egg-white induced edema
hi stamine -induced
bronchospasm 8459
inhibitor activity 8459
serotonin-induced edema 8459
PHENELZINE (194)
Evans blue dye accumulation 8504
experimental inflammation 8504
Beta-PHENETHYL HYDRAZINE
(PHENELZINE) (195)
ganglionic blocking action 8480
PHENOBARBITAL (196)
Cd4 modification 8490
enzyme induction 8490
ethionine modification 8490
hexobarbital sleeping time 8490
microsomal-stimulating agent 8490
PHENOBARBITAL-C14 (197)
brain levels 8493
respiratory acidosis 8493
respiratory alkalosis 8493
selected areas 8493
PHENOLSULFONPHTHALEIN (198)
butyric acid facilitation 8495
intestinal absorption 8495
intraluminal environment 8495
PHENOXYBENZAMINE (199)
cation exchanges 8471
Cd4 hepatotoxicity 8497
indirect stimulation 8471
muscle contractility 8471
protective action 8497
skeletal muscle in situ 8471
Beta-PHENYLISOPROPYLHYDRAZINE
(PIH) (200)
ganglionic blocking action
(204)
8471
8471
8471
8471
8471
8464
8464
8464
8453
8453
(205)
(206)
(207)
8471
(201)
(202)
(208)
8471
8454
8487
8487
8454
8471
8471
8491
8504
8504
8504
8504
8500
8500
8500
8458
8485
8458
(209)
1961
SUBJECT INDEX
PHE-POL
S -17
grouped mice
mortality
motor activity
PHOSPHATE-P32 INORGANIC
gentian violet
penicillin
S. aureus incorporation
PICROTOXINgrouped mice
mortality
motor activity
PILOCARPINE
anesthetized cats
Ca45 uptake
ganglionic receptors
8459 ganglionic stimulant action
hexamethonium pretreatment
K42 uptake
kidney
methadone
morphine
nicotine
pressor response
renal blood flow
reserpine pretreatment
spinal cats
submaxillary gland
submaxillary gland blood
TEA
TM 10
TMA
tyramine comparison
PIPEROXAN
cation exchanges
contraction amplitude
direct stimulation
indirect stimulation
rat phrenic-nerve diaphragm
in vitro
PIPRADOL
grouped mice
mortality
motor activity
PITUITARY HORMONES
methadone absorption
methadone dispositiop.
PLASMA
adr�riergic blockade
contracting skeletal muscle
in situ
8480 disappearance rate
8464 estrogen treatment
8464 free amino acid levels
8464 nitrofurantoin levels
potassium levels
8448 sodium levels
8448 triamcinolone-H3 half-life
8448 PLASMA VOLUME
capillary permeability
8464 Evans blue space
8464 experimental inflammation
8464 rat tissues
(203) POLYPEPTIDES
bradykinin
chromatography
discrimination indices
POL-RES VOL. 131
electrophoresis 8500 methadone absorption 8453
kallidin 8500 serotonin-induced edema 8459
urine flow 8500
POTASSIUM (210)
adrenalectomy 8456 QUATERNARY ANMONIUN COMPOUNDS
desoxycorticosterone 8456 benzomethaniine (218)8494
renal excretion 8455 8495
renal tubular function 8456 experimental procedures 8494
serotonin 8455 intestinal absorption 8494
stop-flow analysis 8456 8495
tubular reabsorption
POTASSIUN’�2 (211)
8455 intraluminal environment 8495
loop-preparations � vivo 8494
kidney uptake 8485 QUINIDINE (219)
pilocarpine effect 8485 action potentials 8479
submaxillary gland uptake 8485 cardiac excitability 8479
PREDNISONE (212) conduction time 8479
inotropic action 8457 depolarization time 8479
mineralocorticoid activity 8457 effective refractory period 8479
papillary muscle 8457 isolated rabbit atria 8479
PROMETHAZINE (213) lactate ion 8479
cyproheptadine comparison 8459 osmolarity 8479
egg-white induced edema 8459 repolarization 8479
inhibitor activity 8459 resting potential 8479
serotonin pressor response 8459 sodium gradient 8479
serotonin-induced edema 8459 sodium lactate reversal 8479
PSYCHOLOGICAL TESTS (214) sodium salt reversal 8479
delayed response 8463 stimulation rate 8479
efficiency decrement 8463 sucrose reversal 8479
nitrous oxide:oxygen 8463
visual discrimination 8463
PTOSIS , PALPEBRAL (215) RECEPTORS , STRETCH (220)
CNS excitants 8474 muscle spindle discharge 8482
dopa influence 8474 ryanodine pretreatment 8482
dopamine influence 8474 succinylcholine effect 8482
5-HT influence 8474 REFRACTORY PERIOD (221)
5-HTP influence 8474 anti-adrenergic effect 8477
iproniazid pretreatment 8474 A-V transmission 8477
isopropyl hydrazine cardiac glycosides 8477
pretreatment 8474 RENAL FUNCTION (222)
reserpine induced 8474 electrolyte excretion 8455
PYRIDOXINE (216) glomerular filtration rate 8455
blood pressure responses 8492 renal plasma flow 8455
deficiency effects 8492 serotonin 8455
hydroxyphenylpyruvic acid tubular loads 8455
in vivo 8492 urine flow 8455
PYRILAMINE (217) R.ESERPINE (223)
cyproheptadine comparison 8459 albino mice 8472
egg-white induced edema 8459 8474
histamine-induced alkylating agents 8473
bronchospasm 8459 anticonvulsants 8474
inhibitor activity 8459 anti-tumor effect 8473
SUBJECT INDEX
5-18
8468
8468
8474
8473
84788478
8474
8474
8478
(225)
(226)
(227)
(228)
(229)
8461
8461
8502
8461
8502
8461
8482
8482
8482
8465
8465
8465
8465
8465
8493
8493
8493
8493
8452
8459
8459
8452
8459
8452
8452
8459
8452
8459
8459
8459
8452
8483
8456
84838483
8456
8483
8483
8483
8455
8456
8455
8456
(224)
8474
8478
8472
8473
84738473
8473
8473
8478
8473
8502
8502
8461
8461
8502
8461
8502
8502
8461
8502
8461
8461
8461
8502
8461
8461
1961SUBJECT INDEX
RES -SOD
S -19
body weight
caffeine tonic extensor
seizures
cardiac phosphorylase
activity
circulating catecholamines
CNS excitants
food intake
graded dose-responses
heart-lung preparation
iproniazid influence
isopropylhydrazine influence
myocardial contractility
oxygen consumption
palpebral ptosispentylenetetrazol tonic
extensor seizures
beta-phenyli sopropylhydrazine
antagonismprotective effect
protein amino-acidincorporat ion
reserpine derivatives
seizure facilitation
sympathetic nerve stimulation
thiopental-induced gangrene
DL-triiodothyronine
combinat ion
tumor growth
tumor protein synthesis
tumor volume
tumor-bearing mice
ventricular function curves
water intake
RESPIRATION
action duration
action mechanism
amplitude
central vagal stimulation
chlorpromazine
CO2 tension
controlled alveolar pCO2
depressant effects
H-ion concentration
human subjects
levallorphan antagonism
meperidine effect
8502
midcollicular decerebration
minute volume
morphine effect
neuronal excitability
8473 rate 8461
85028474 reflex mechanisms
rhythm changes
simultaneous administration
stimulus threshold
tidal volume
vagotomized cats
RYA.NODINE
anesthetized cats
muscle spindle discharge
succinylchol me
8473
8474 SALICYLATE
albino rats
8474 behavior responses
central nervous system
8474 pain tolerance
8472 tolerated shock level
SALICYLIC ACID-C14
8473 brain levels
8473 respiratory acidosis
respiratory alkalosis
selected areas
SEROTONIN
c14 labeled
cyproheptadine antagonism
“ganglion-blocked” dog
5HIAA formation
local edema
MAO inhibitors
metabolism in vivo
pressor responses
radioactive metabolites
rat uterus
reference agents
spasmogenic effect
urinary metabolites
SODIUM
action mechanism
adrenal ec tomy
cocaine antagonism
cocaine concentration
desoxycorticosterone
ion concentration
nerve conduction block
neural function
renal excretion
renal tubular function
5 e rot onin
stop-flow analysis
(230)
8479
8479
8479
8497
8497
8497
8448
8448
heart rate
heart-lung preparation
myocardial contractility
peripheral anti-adrenergic
effect
postganglionic stimulation
8478
reserpine pretreatment
sympathetic discharge
SYMPATHETIC NERVOUS SYSTEM,
8481 GANGLION (239)
8481 ganglionic blocking agents
8481 histamine pressor response
8481 pilocarpine pressor response
sympathin release
SYMPATHETIC NERVOUS SYSTEM,
PERIPHERAL (240)
8458
8458
8458
8458
SOD-THE
tubular loads 8455 digitalis inhibitor activity 8477
tubular reabsorption 8455 digitoxin effect 8476
SODIUM LACTATE epinephrine infusion 8476
isolated rabbit atria functional state 8468
quinidine effect 8477
reversing action 8478
SPINAL CORD (231) 8478
C6 transection
CC14 hepatotoxicity 8477
protective action 8476
STAPHYLOCOCCUS AUREUS (232)cell wall synthesis 8478
penicillin 8497
STOMACH (233)
anesthetized dog
atropine inhibitor activity
contraction response
vagal stimulation
STRYCHNINE (234)
albino rats 8475
convulsant effects 8475
maturation influence 8475 blood pressure 8498
toxic effects 8475 guanethidine blocking action 8498
SUBMAXILLARY GLAND (235) vascular effectors 8498
blood flow 8485 SYMPATHIN (241)
Ca45 uptake 8485 adrenalectomy 8458
fractional distribution
K42 uptake
8485
8485
adrenergic postganglionic
terminals 8458
pilocarpine effect 8485 histamine-induced liberation 8458
SUCCINYLCHOLINE (236) methadone 8458
action potentials 8482 morphine 8458
anesthetized cats 8482 pilocarpine-induced
fusimotor stimulation 8482 liberation 8458
intrafusal fiber response 8482 TM-lO 8458
mammalian muscle spindles 8482 SYNPATHOMIMETIC ANINES (242)
muscle contracture 8482 1-epinephrine 8467
muscle stimulation 8482 isolated perfused rat heart 8467
ryanodine pretreatment 8482 myocardial phosphorylase a
spindle discharge frequency 8482 activity 8467
stretch receptors 8482 positive inotropic action 8467
SYMPATHETIC BLOCKADE,
POSTGANGLIONIC (237)
bretylium 8468 THENA.LIDINE (243)
cardiac phosphorylase cyproheptadine comparison 8459
activity 8468 egg-white induced edema 8459
SYMPATHETIC NERVOUS SYSTEM (238) histamine-induced
acetyldigitoxin effect 8476 bronchospasm 8459
auricular fibrillation 8477 inhibitor activity 8459
auricular flutter 8477 serotonin pressor response 8459
cardiac acceleration 8476 serotonin-induced edema 8459
cardiac phosphorylase TH.EOPHYLLINE (244)
activity 8468 aminotheophylline comparison 8486
CC14 hepatotoxicity 8497 diuretic effect 8486
SUBJECT INDEX
VOL. 131
5-20
THIOPENTAL (245)gangrene production
injection site
reserpine effect
subcutaneous injection
ulcer production
TISSUE (246)
Evans blue dye concentration
experimental inflammation
histamine inhibitors
histamine liberators
histamine pretreatment
plasma volumes
quantitative measurement
serotonin
serotonin inhibitors
serotonin liberators
TISSUE, TUMOR (247)
amino-acid incorporation
reserpine effect
starvation diet
tumor-bearing mice
TRANSMISSION, A-V (248)
anti-adrenergic effect
metabolism in vivo
TIJNGSTATE, SODIUM (255)blood methanol disappearance
liver homogenates
methanol metabolism in vitro
sodium molybdate
xanthine oxidase activity
TYRAMINE (256)
histamine comparison
pilocarpine comparison
pressor response
rn-TYROSINE (257)
decarboxylationHCS blocking effect
pressor effect
rn-tyramine formation
8477 brain levels
8503injection 8503
8503
selected areas
URETHAN (260)CC14 modificationenzyme induction
ethionine modificationhexobarbital sleeping time
microsomal-stimulating agent
UTERUS (261)
estradiol effect
free amino acids
ovariectomized rats
cardiac glycosides 8477
functional refractory period 8477
TRANSMISSION, GANGLIONIC (249)
ACh stimulatory action 8480
monoamine oxidase inhibitors 8480
nictitating membrane response 8480
pentobarbitalized cats 8480
perfused cervical ganglion 8480
preganglionic stimulation 8480
TRANS -2-PHENYLCYCLOPROPYL-
AMINE (PCA) (250)
ganglionic blocking action 8480
TRIA}�INOLONE-H3 (251)
blood concentration
plasma half-life
radioactivity excretion
tissue distribution
TRIFLUPROMAZINE (252)
antiemetic activity
fluphenazine comparison
TRIMEPRAZINE (253)
cyproheptadine compari son
egg-white induced edema
inhibitor activity
serotonin pressor response
serotonin-induced edema
TRYPTAMINE (254)
IA�A formation
MAO inhibitors
E. coli incorporation
8466 penicillin
8466 VASOCONSTRICTORS
amphetamine
(262)
(263)
(264)
(265)
pharmacologic response
1961
SUBJECT INDEX
S -21
8472
8472
8472
8472
8472
8504
8504
8504
8504
8504
8504
8504
8504
8504
8504
8473
8473
8473
8473
8491
8491
8491
8491
8459
84598459
8459
8459
8452
8452
ULTRAVIOLET LIGHT
animal exposure
8 -methoxypsoralen
toxicity studies
UREA-C14
respiratory acidosis
respiratory alkalosis
taurine levels
weight changes
VALINE -C14
femoral vascular bed
methylphenidateVASOPRESSIN
methadone absorption
XANTHINES
diuretic effect
THI-XAN
(258)
(259)
8452
8469
8469
8469
8469
8469
8458
8458
8458
84928492
8492
8492
8493
8493
8493
8493
8490
8490
84908490
8490
8487
8487
8487
8487
8487
8448
8448
8499
8499
8499
8453
8486
8486
84628491
8449
85018503
8471
8490
Inesi C 8467
1961AUTHOR INDEX
VOL. 131
A-i
Aceves J
8477
Adair E J
Adler M W
Albert J R
Alford D
Angell E A
Aprison N H
8476 Ferster C B
Florini J R
8470 Fouts J R
8463 Free S M Jr
8460 Freeman R G
8488 Friedman S M
8455 Fujimoto J M
8462
Baird G M
Barlow C F
Bauer R 0Beach V L
Blinks J RBohner B
Boudet R A
Bowen E H Jr
Boxill G CBrody T M
Brooks WBukovsky J
Burgison R M
Burke J C
Burn J H
Buyske D A
Buzard J A
Cafruny E J
Calvert D N
Campbell A D
Chen G
Clark W C
Coles F K
Condouris C A
Conklin J D
Cox A R
Craver B N
Daniel A I
Day M
Dreisbach R H
Drell W
Eldred E
Elison C
Elliott H W
Eubank L L
8473
8493
85018504
8478
8474
8488
8501
84608497
8455
84898486
8466
8472
8491
8454
8484
8497
8451
8474
8492
8451
8483
8454
8479
8466
8499
8450
8485
8492
8482
8453
8453
8451
Gertner S B
Goldberg M A
Green J P
Creenblatt E N
Griffin A C
Hakim R EHaugaard N
8468Hensala J C
Hess M E
8468
Holland R
Huf E C
}Iuffman W
Jarvik M E
Kalman S N
Kaneko Y
Kerby C F
Knox J N
Krantz J C Jr
Kukovetz W R
Laffan R J
Lambertsen C J
Laties V C
Leibman K C
Levine R R
8495 8496Little J N
Lombrozo N E
Longenhagen J B
Lovenberg W
Ludden C T
8480
8493
8450
8464
8503
8503
8467
8486
8467
8499
8451
8455
8463
8487
8498
8457
8503
8486
8467
8466
8502
8465
8488
8494
8455
8487
85028452
8459
8498
8472
8470
8496
8449
8469
8499
8476
8467
8456
8456
84828471
8459
8504
8473
84598448
8499
84578469
8458
O’Keefe E
Osterberg A C
Van Arman C C 8500
Yard A S
Zirkle C S 8496
1961AUTHOR INDEX
VOL. 131
A-2
McCubbin J W
McDougal D B Jr
McKennis H Jr
McLean R
McLuen E FMannering C J
Maxwell R A
Mendez C
8477
Mendez R
8477
Miller L N
Nathenson S G
Ngai S H
Page I H
Palmer J F
Papandrianos D P
Parks R E Jr
Paul N F
Peets E A
Pelikan E W
Plaa C L
Pogrund R S
Pradhan S N
Pylkko 0 0
Redfield B G
Robinson J D Jr
Ross C A
Roth J S
Roth L J
Schneider A F
Schneider F
Shanfeld J
8468
Shideman F E
Skulan T W
Smith C N
Sreter F A
Stavorski J N
Steinetz B C
Steward J D
8476 Stone C A
Strominger J L
8500 Sylwestrowicz H D
8448 Tanz R D
8461 Tephly T R
Trendelenburg U
8454
8464
8498
8484
8466
8469
8454
8491
8494
8490
8492
8473
8475
8452
84508459
8489
8493
8497
8499
Udenfriend S
Ursillo R C
Waud D R
Weatherby J H
Weikel J H Jr
Weinstock J
Weiss B
Weissbach H
Wendel H
Wenger H C
West T C
West W L
Williamson H E
Woodbury D N
8452
8481
8478
84708460
8496
8465
8452
8502
8459
8479
8473
8456
8475
8470
JANUARY
Entry
8448 1
8449 78450 12
8451 18
8452 26
8453 31
8454 38
8455 44
8456 498457 56
8458 65
8459 73
8460 85
8461 91
8462 100
8463 108
8464 115
8465 120
8466 130
Auxiliary Index-Part I
Index to Pages
VOLUME 131, 1961
FEBRUARY
Entry
8467 137
8468 1438469 147
8470 152
8471 158
8472 167
8473 171
8474 179
8475 185
8476 191
8477 199
8478 205
8479 212
8480 223
8481 231
8482 237
8483 243
8484 250
8485 257
8486 261
8487 265
MARCH
Entry
8488
8489
8490
8491
84928493
84948495
84968497
84988499
8500
8501
8502
8503
8504
271
275282287
294
308
319
328
334341
346
355
366
373
381
394
400
Al-i
1961 NOTICE VOL. 131
to Subscribers and Readers
Because of the comprehensive nature of the Journal index, the following
explanatory comment, with special reference to subject analysis, seems ap-
propriate at this time.
Subject Content: This is available to the reader through simple, coordin-
ate search of the Subject Index. Coincident display of pertinent headings
and subheadings, arranged alphabetically, assures the searcher that signif-
icant information will not be missed. The information thus acquired may
be divided into three categories:
First: The Number of Articles Cited on Each Subject.
Rapid survey of the entry numbers listed opposite the subheadings will
indicate the scope and variety of topic coverage. The subheadings describe
the subject content in unit terms, with separate access afforded for each
idea. For the convenience of direct page reference, AUXILIARY INDEX-PART I
presents a table of Index to Pages.
Second: The Number of Subjects Covered in Each Article.
The Subject Index admits topic headings according to the relative impor-
tance of the competing information in each article, and by careful selec-
tion, the duplication of subject headings is minimized, without sacrificing
essential flexibility. By the liberal use of such heading�, numbered ser-
ially in parenthesis, complete cross-reference is simple and productive,
free from the accumulation of cumbersome “see” and “see also” listings in
common use.
For the purpose of cross-reference the short index of alternative headings
represented in AUXILIARY INDEX-PART II is recommended. The appropriate head-
!.a& numbers are arranged below the underscored entry numbers, and can bequickly located by first consulting the parenthetic numbers in the Subject
Index.Third: The Associations of Ideas Related to the Subject of Search.
Ready comparison of ideas described under one heading with those listed
under the alternative headings will often lead to a fund of relevant facts.
In this manner, tracing ideas through the total system should open the way
to useful material that is beyond the limits of restricted fields of inquiry.
1961 Auxiliary Index-Part II VOL. 131
Index to Subject Headings
8448 8453 8458 8463 8469 8474 8480 8487 8493 8499
34 1 10 70 25 223 200 207 197 102
44 8 52 181 50 249 261 227 123
69 10 113 214 101 8475 250 259 166
87 13 133 107 15 8488 179
104 28 178 160 57 8481 3 8494 182116 38 203 8464 163 70 43 47 1 191
117 80 239 26 255 79 49 64 45 263
157 134 241 27 234 52 101 145
189 160 256 53 8470 175 218 8500
201 161 58 50 � 188 �! 51
232 206 8459 70 66 6 233 83 8495 52262 217 37 162 118 89 101 1 54
264 41 166 135 102 8482 155 32 94
� 48 200 153 119 172 158 45 149
2 � 52 202 160 128 220 160 68 171
23 1 73 205 238 225 111 209
27 115 74 8471 236 8490 145
74 160 81 � 11 �2�Z 63 198 8501
76 180 93 70 50 6 8483 100 218 29
84 207 97 185 67 33 75 108 86
101 113 226 77 88 174 132 8496 169
131 � 133 170 89 229 160 1 186
148 72 137 8466 176 119 196 121
154 98 156 36 199 123 8484 260 179
160 140 171 74 204 183 82 8502
150 193 99 207 221 92 8491 8497 19
� 210 213 112 238 95 14 9 29
5 222 217 192 8472 248 129 50 10 62
21 229 228 252 114 150 136 12 74
55 243 223 8478 159 160 63 158
71 � 253 � 245 78 207 101 173
133 10 101 126 8485 251 103 224
140 85 � 125 8473 223 59 154
144 151 20 242 18 238 150 8492 199
182 210 35 22 203 52 231 8503
229 109 8468 39 8479 211 90 238 46
�_4a 10 184 124 235 91 154160 � � 31 223 219 138 8498 165164 14 70 56 247 230 8486 139 52 258
80 152 101 24 160 65
85 158 113 8474 8480 52 216 120 8504127 169 123 35 5 96 257 191 30
� 143 224 130 40 122 244 240 60101 183 223 58 146 265 8493 110
146 187 237 70 147 4 8499 140
160 212 238 146 168 8487 7 27 142
167 8462 168 177 22 17 42 194
228 � 70 8469 190 179 105 61 52 208
254 9 141 16 215 195 106 70 65 246
AI-2