STUDY PROGRAM 2017/2018 Subjects of the 7-8. semesters … · 2017-08-10 · Drugs acting on...

UP FP Pharmacy major – obligatory subjects of the 7-8. semester - Course descriptions – academic year of 2017/2018

1

University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2017/2018

Subjects of the 7-8. semesters

(obligatory subjects and criterion requirements)


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7th semester

OPG-GAI ________ Pharmaceutical Applied Immunology _________________________________________________________ 3

OPG-GH1 _______ Pharmacodynamics 1 ______________________________________________________________________ 5

OPG-GI2 ________ Pharmaceutical Practice and Management 1 ____________________________________________________ 8

OPG-GK3 _______ Pharmaceutical Chemistry 3 ________________________________________________________________ 11

OPG-GT3 ________ Pharmaceutical Technology 3 _______________________________________________________________ 14

OPO-GOP _______ Pharmaceutical Pathology __________________________________________________________________ 17

OPO-KE1 ________ Public Health 1 __________________________________________________________________________ 19

8th semester

OPG-GH2 _______ Pharmacodynamics 2 _____________________________________________________________________ 22

OPG-GI3 ________ Pharmaceutical Practice and Management 2 ___________________________________________________ 25

OPG-GK4 _______ Pharmaceutical Chemistry 4 ________________________________________________________________ 28

OPG-GT4 ________ Pharmaceutical Technology 4 _______________________________________________________________ 32

OPO-KE2 ________ Public Health 2 __________________________________________________________________________ 35

OPO-KL1 ________ Clinical Studies 1 ________________________________________________________________________ 38


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OPG-GAI PHARMACEUTICAL APPLIED IMMUNOLOGY

Course director: DR. JUDIT PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology

2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-IMM completed

Topic

Immunology from a pharmaceutical aspect.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Writing test

Making up for missed classes

According to the Code of Studies and Examinations.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

Lecture notes, learning materials of the lectures are available on MeetStreet

- Recommended literature

Lectures

1 Overview of the immunresponse mechanisms 1.

Dr. Pongrácz Judit

2 Overview of the immunresponse mechanisms 2.

Dr. Pongrácz Judit

3 Potentials for regulation of the immunresponse 1.

Dr. Pongrácz Judit

4 Potentials for regulation of the immunresponse 2.

Dr. Pongrácz Judit

5 Identification of therapeutic target molecules and processes 1.

Dr. Pongrácz Judit

6 Identification of therapeutic target molecules and processes 2.

Dr. Pongrácz Judit

7 Vaccination 1.

Dr. Kvell Krisztián

8 Vaccination 2.


9 Citokines


10 Interferons


11 MHC tetramer techniques


12 Herpes simplex virus in therapy


13 Complex lytic viruses in therapy


14 Modified viruses and their therapeutic applications 1.


15 Modified viruses and their therapeutic applications 2.



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16 Modified bacterial strains and their therapeutic applications


17 Recombinant virus therapies


18 Cell therapy 1.

Dr. Járomi Luca

19 Cell therapy 2.

Dr. Járomi Luca

20 Monoclonal therapies: Tumor therapies

Dr. Járomi Luca

21 Monoclonal therapies: Autoimmune therapies

Dr. Járomi Luca

22 Immunoassay methods and their application in pharmaceutical analysis

Dr. Járomi Luca

23 Application of IVIG treatment in autoimmune and infectious diseases and tumour treatment

Dr. Járomi Luca

24 Application of GvHD in tumour treatment

Dr. Járomi Luca

25 Application of the microbiome in treatment of autoimmune diseases

Dr. Pongrácz Judit

26 Application of familial microphlora transplantation in autoimmune diseases

Dr. Pongrácz Judit

27 Basic methods and recent advances

Dr. Pongrácz Judit

28 Individual presentations

Dr. Pongrácz Judit

Practices

Seminars

Exam topics/questions

MeetStreet

Participants


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OPG-GH1 PHARMACODYNAMICS 1

Course director: DR. BALÁZS FERENC NÉMETI, associate professor

Department of Pharmacology and Pharmacotherapy



Course headcount limitations (min.-max.): 1 – 100 Prerequisites: OPO-KTN completed

Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of

pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic

nervous system and the cardiovascular system. It must be emphasized that the knowledge of the physiological principles is absolutely

needed for the study of this subject.



Mid-term exams

Around the 11th week of the semester, a written test is the base of the judgement of performance. The test covers the subjects of seminar

classes of the first 10 weeks of the semester. Students are required to reach at least 60%. Should someone fail in reaching 60%, the

semester performance will not be accepted and the student cannot take the exam. On such occasion, students not reaching the required

60% on the first midterm test will have the possibility to improve their results one time by the end of the semester. On a final failure (that

is, after the improvement attempt), the student cannot take the exam.


There is no way to make up for missed lectures or seminars.

Reading material



- Notes


Rang, Dale, Ritter, Moore: Pharmacology, 8th edition, Elsevier Churchill Livingstone, 2015

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012

Lectures

1 Introduction to neuropharmacology. General characterization of the autonomic nervous system

Dr. Németi Balázs Ferenc

2 Cholinergic agonists


3 Cholinesterase inhibitors I


4 Cholinesterase inhibitors II


5 Muscarinic receptor antagonists I


6 Muscarinic receptor antagonists II


7 Neuromuscular blocking agents I

Dr. Pethő Gábor

8 Neuromuscular blocking agents II

Dr. Pethő Gábor

9 Agents acting on biosynthesis, storage, release and elimination of catecholamines I

Dr. Pethő Gábor

10 Agents acting on biosynthesis, storage, release and elimination of catecholamines II

Dr. Pethő Gábor


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11 Adrenergic receptor agonists I


12 Adrenergic receptor agonists II


13 Adrenergic receptor antagonists I


14 Adrenergic receptor antagonists II


15 Pharmacology of calcium channels I

Dr. Poór Miklós

16 Pharmacology of calcium channels II

Dr. Poór Miklós

17 Drugs acting on the renin-angiotensin-aldosterone system I

Dr. Poór Miklós

18 Drugs acting on the renin-angiotensin-aldosterone system II

Dr. Poór Miklós

19 Diuretics I

Dr. Pethő Gábor

20 Diuretics II

Dr. Pethő Gábor

21 Drugs used to treat congestive heart failure I

Dr. Barthó Loránd

22 Drugs used to treat congestive heart failure II

Dr. Barthó Loránd

23 Antianginal drugs I


24 Antianginal drugs II. Drugs that increase regional blood flow


25 Antihypertensive drugs I

Dr. Pethő Gábor

26 Antihypertensive drugs II

Dr. Pethő Gábor

27 Antiarrhythmic drugs I

Dr. Pethő Gábor

28 Antiarrhythmic drugs II

Dr. Pethő Gábor

Practices

Seminars

1 Introduction to pharmacodynamics I

2 Introduction to pharmacodynamics II

3 Basic mechanisms of drug actions

4 Characterization of agonist-receptor interaction I

5 Characterization of agonist-receptor interaction II

6 Characterization of agonist-receptor interaction III

7 Signal transduction mechanisms of drug receptors

8 Tachyphylaxis and tolerance to drugs

9 Mechanisms of drug antagonisms I

10 Mechanisms of drug antagonisms II

11 Transport of drugs across membranes

12 Absorption of drugs I

13 Absorption of drugs II. Binding of drugs to plasma proteins

14 Distribution of drugs

15 Biotransformation of drugs I

16 Biotransformation of drugs II

17 Biotransformation of drugs III

18 Excretion of drugs


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19 Pharmacokinetic parameters I

20 Pharmacokinetic parameters II

21 Local anesthetics I

22 Local anesthetics II

23 Discussion of the pharmacology of the neuromuscular junction

24 Drugs acting on autonomic ganglia

25 Discussion of the pharmacology of the parasympathetic nervous system I

26 Discussion of the pharmacology of the parasympathetic nervous system II

27 Discussion of the pharmacology of the sympathetic nervous system I

28 Discussion of the pharmacology of the sympathetic nervous system II


Reqirements: the exams are oral, the required topics are dealt with during the semester lectures and seminars.

Exam questions:

1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated

by physicochemical interactions)

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs, oral bioavailability and presystemic elimination

7. Plasma protein binding and tissue distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses

11. Cholinergic agonists and cholinesterase inhibitors

12. Muscarinic receptor antagonists

13. Neuromuscular blocking agents. Drugs acting on autonomic ganglia

14. Agents acting on the biosynthesis, storage, release and elimination of catecholamines

15. Adrenergic receptor agonists

16. Adrenergic receptor antagonists

17. Local anaesthetics

18. Calcium channel blockers

19. Drugs acting on the renin-angiotensin-aldosterone system

20. Diuretic drugs

21. Positive inotropic and other drugs used to treat congestive heart failure

22. Antianginal drugs. Drugs that increase regional blood flow

23. Antihypertensive drugs

24. Antiarrhythmic drugs

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the

student.

Participants

Bálint Mónika Enikő (E4CS9B), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Poór Miklós (POMNAAO.PTE)


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OPG-GI2 PHARMACEUTICAL PRACTICE AND MANAGEMENT 1

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy



Course headcount limitations (min.-max.): 5 – 50

Prerequisites: OPG-GI1 completed + OPG-GK1 completed + OPG-GT1 completed

Topic

The undergraduates acquire knowledge of the innovation of a new drug from a drug candidate, the formation of the legal validity of

official indications, as well as grouping and professional explanation of unwanted effects. The topics of the semester introduce the basic

functioning of medical market, the fundamentals and specifications of economic relations. Methods of comprehensive analysis,

evaluation and development of drug therapy, healthcare systems, the framework and regulation of pharmaceutical supply will be covered

throughout the semester. Interactive discussions will cover essential topics regarding self-medication and over the counter products used

in minor diseases. Students will improve their communicational skills in order to counsel patients more efficiently and improve adherence

to medications. Basic knowledge of earlier theoretical studies is beneficial.

Aims of lectures in pharmaceutical studies: Basic aim of these studies is to solidify pharmacy practice and related economic,

communicational, drug development and authorization knowledge in order to understand pharmacoeconomics, drug allocation,

pharmaceutical management, health economics, evidence based medicine and in general pharmaceutics. This knowledge will support

later studies in these fields. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional

studies. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills. Topics

discussed during the lectures, but not included in the notes/books will also be included in the exams. Students can access the slides of

the lectures and further reading material on a designated web based interface (Neptun Meet Street).


- Regular attendance of classes/lectures (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- The mid-term and end-of-the-term test(s) should be passed (60,1%, minimum grade 2).

Mid-term exams

End-of-semester grade is given by end-of-the-term test’s result, any tests written throughout the semester and student performance during

the semester.

Examination and granting of grades: for Pharmaceutical Practice and Management 1 and 2 the end-of-the term test’s grade may be

accepted as an examination grade if passed.

Retake opportunity is possible following personal discussion.



Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun MeetStreet.

- Notes


J.L. Bootman, R. J. Townsend, W. F. McGhan (eds.): Principles of Pharmacoeconomics, Harvey Whitney Book Company, 2002.

Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, 6th edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012.

Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 17th edition, American Pharmacists Association,

2012.

John P. Griffin, John Posner, Geoffrey R. Barker: The Textbook of Pharmaceutical Medicine, 7th Edition, 2013.

Lectures

1 Drug authorization process, Patent of drugs 1

Dr. Miseta Ildikó

2 Drug authorization process, Patent of drugs 2

Dr. Miseta Ildikó


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3 Variations of authorization processes (orphan drugs, generic, etc.)

Dr. Miseta Ildikó

4 Drug Research and Development 1

Dr. Vida Róbert György

5 Drug Research and Development 2


6 Nonclinical studies, preclinical development, Design and methodology in clinical trials


7 Simulation of a small, pilot clinical study

Dr. Miseta Ildikó

8 Clinical trials 1


9 Clinical trials 2


10 Clinical trials 3


11 Monitoring clinical trials

Dr. Miseta Ildikó

12 Equivalencies of drugs 1

Dr. Miseta Ildikó

13 Equivalencies of drugs 2

Dr. Miseta Ildikó

14 Pharmacovigilance 1

Dr. Fittler András Tamás

15 Pharmacovigilance 2


16 Organisation of Hungarian health system


17 Principles and basic terms of economics


18 The drug supply chain, participants of the drug market


19 Market mechanisms


20 Social insurance systems


21 Economic actors, sectors of economy


22 Social insurance in Hungary


23 Money, incomes, investments, taxation, redistribution


24 Requirements of opening and operation of pharmacies. Regulation of public drug supply


25 Inflation, national production, GDP


26 Regulation regarding prescribing and dispensing of medicines in Hungary. Limitation of distribution of medicines in the EU


27 The imperfect market of healthcare


28 Test

Dr. Botz Lajos

Practices

Seminars

1 Basics of communication 1

2 Basics of communication 2


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3 Communication skills in pharmacy practice 1

4 Communication skills in pharmacy practice 2

5 Medication safety and communication

6 Introduction - self-care, legal issues

7 Introduction - patient assessment and consultation

8 Sample presentation, PowerPoint presentation scheme

9 Nutrition, mineral replacement and vitamins

10 Dry skin, atopic dermatitis

11 Acne, prevention of sunburn, skin hyperpigmentation

12 Minor burns, wounds

13 Smoking cessation

14 Test


Based on the topics of the lectures and seminars.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Miseta Ildikó (MIIOAA-O.PTE), Dr. Végh Anna

(VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


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OPG-GK3 PHARMACEUTICAL CHEMISTRY 3

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry



Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GK2 completed

Topic

Introduction to the most important instrumental analytical methods and their applications to pharmacopoeal qualification of active

pharmaceutical ingredients and experiments. Introduction to molecular aspect and structure-activity relationship of selected group of

active pharmaceutical ingredients.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written

during the semester on the 7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after

both tests. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical

work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum

requirement of acknowledgement of the semester.

Mid-term exams


There is no opportunity to make up missed classes.

Reading material


D.A. Williams, T.L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins,

Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic

educational material, PTE 2014

- Notes

Pharmaceutical Chemistry Practice 1, laboratory manual, University of Pécs, 2015


European Pharmacopoeia, EDQM Publication

Lecture notes

Lectures

1 Application of CD and ORD spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

2 Application of UV-Vis spectroscopy in pharmaceutical analysis

Dr. Perjési Pál

3 Application of UV-Vis spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

4 Application of thermoanalytic methods in pharmaceutical analysis.

Kulcsár Győző

5 Application of fluorimetry in pharmaceutical analysis.

Dr. Perjési Pál

6 Application of fluorimetry in pharmaceutical analysis.

Dr. Perjési Pál

7 Application of atomic absorption spectrometry and flame photometry in pharmaceutical analysis.

Kulcsár Győző

8 Application of IR spectroscopy in pharmaceutical analysis.

Dr. Lóránd Tamás

9 Application of IR spectroscopy in pharmaceutical analysis.

Dr. Lóránd Tamás


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10 Non-steroid analgesics and antipyretics.

Dr. Perjési Pál

11 Application of NMR spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

12 Application of NMR spectroscopy in pharmaceutical analysis.

Dr. Perjési Pál

13 Non-steroid anti-inflammatory agents I.

Dr. Perjési Pál

14 Application of mass spectrometry in pharmaceutical analysis.

Kulcsár Győző

15 Application of mass spectrometry in pharmaceutical analysis.

Kulcsár Győző

16 Non-steroid anti-inflammatory agents II.

Dr. Perjési Pál

17 Application of electroanalytical methods in pharmaceutical analysis.

Dr. Perjési Pál

18 Application of electroanalytical methods in pharmaceutical analysis.

Dr. Perjési Pál

19 Antiallegic antihistamines. Drugs for rheumatic gout I.

Dr. Almási Attila

20 Agents of cardiac failure.

Dr. Perjési Pál

21 Agents of cardiac failure.

Dr. Perjési Pál

22 Antiallegic antihistamines. Drugs for rheumatic gout II.

Dr. Almási Attila

23 Agents of antiarythmic agents.

Dr. Almási Attila

24 Agents of antiarythmic agents.

Dr. Almási Attila

25 Antianginal drugs.

Dr. Perjési Pál

26 Antihipertensive agents.

Dr. Almási Attila

27 Antihipertensive agents.

Dr. Almási Attila

28 Antithrombotics, Thrombolytics, Coagulants.

Dr. Perjési Pál

29 Antihiperlidemic agents.

Dr. Huber Imre

30 Antihiperlidemic agents.

Dr. Huber Imre

31 Antithrombotics, Thrombolytics, Coagulants.

Dr. Perjési Pál

32 Diuretics.

Dr. Huber Imre

33 Diuretics.

Dr. Huber Imre

34 Drugs affecting thyroid functions.

Dr. Perjési Pál

35 Drugs affecting calcium homeostatis.

Dr. Kuzma Mónika

36 Drugs affecting calcium homeostatis.

Dr. Kuzma Mónika

37 Biological drugs.

Dr. Huber Imre


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38 Insulin and oral hypoglycemic drugs.

Dr. Kuzma Mónika

39 Insulin and oral hypoglycemic drugs.

Dr. Kuzma Mónika

40 Adrenocorticoids.

Dr. Perjési Pál

41 Estrogens, Androgens, Progestins.

Dr. Perjési Pál

42 Estrogens, Androgens, Progestins.

Dr. Perjési Pál

Practices

1 Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I.

Identification of 10 inorganic and organic substances I.

2 Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I.

Identification of 10 inorganic and organic substances I.

5 Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic

substances II.

9 Principles of validation of analytical methods I-II. (Seminars)

13 Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according

to the Ph. Hg. VII. and the Ph. Hg. VIII.

17 Spectrophotometry I. The Lambert-Beer’s law. Determination of specific absorbance. Spectrophotometric determination of

coffein, aminophenazone and paracetamol in powder mixtures.

21 Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric

methods.

25 1st Midterm Test. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra

of selected drug substances. (Seminar)

29 Principles of drug stabilty studies. Decompositions in liquid and solid states. (Seminars)

33 Basics of reaction kinetics. The dependence of drug degradation rate on temperature and pH. Analysis of degradation of

acetylsalicylic acid.

37 Application of electroanalytical methods in pharmaceutical analysis. (Seminar)

41 Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a

weak acid in mixtures.

45 Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by

direct potentiometric titration.

49 2nd Midterm Test. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.

53 Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR

spectra of selected drug substances. (Seminar)

Seminars


Written test covering the topics of the lectures and the laboratory practices. The result of the written test must be above 60%. The final

grade is based on results of the midterm tests and the written test. Maximum contribution of the results of the midterm tests to to the

total score of the written test can be 25%. Participation on the first exam is compulsory.

Participants

Nyúl Eszter (NYESAAO.PTE)


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OPG-GT3 PHARMACEUTICAL TECHNOLOGY 3

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy




Prerequisites: OPG-GK2 completed + OPG-GT2 completed + OPG-GH1 parallel

Topic

Mainly semisolid dosage forms are prepared in this semester: suppositories and vaginal suppositories. Powders and capsules as solid

dosage forms are also prepared and discussed.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade. In case of

fulfilled 1-3 sections, the requirement of the accepted semester is to reach at least satisfactory grade.

Mid-term exams


Students must fulfil requirements determined by the Code of Studies and Examinations.

All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu

www.sciencedirect.com

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

1 Cristallisation, polymorphism, and their technological aspects

Dr. Pál Szilárd

2 Cristallisation, polymorphism, and their technological aspects

Dr. Pál Szilárd

3 Drying, freeze-drying

Dr. Pál Szilárd

4 Drying, freeze-drying

Dr. Pál Szilárd

5 Grinding and shieving

Dr. Pál Szilárd

6 Grinding and shieving

Dr. Pál Szilárd

http://www.gytk.pte.hu/

http://www.sciencedirect.com/


15

7 Preparation of granules I

Dr. Pál Szilárd

8 Preparation of granules I

Dr. Pál Szilárd

9 Preparation of granules II

Dr. Pál Szilárd

10 Written test

Dr. Pál Szilárd

11 Fluidization and its application

Dr. Pál Szilárd

12 Fluidization and its application

Dr. Pál Szilárd

13 Pharmaceutical excipients of granules

Dr. Pál Szilárd

14 Pharmaceutical excipients of granules

Dr. Pál Szilárd

15 Tabletting I

Dr. Pál Szilárd

16 Tabletting I

Dr. Pál Szilárd

17 Tabletting II (excipients, examinations)

Dr. Pál Szilárd

18 Tabletting II (excipients, examinations)

Dr. Pál Szilárd

19 Excipients for the preparation of tablets and granules

Dr. Pál Szilárd

20 Written test

Dr. Pál Szilárd

21 Coating of preparations

Dr. Pál Szilárd

22 Coating of preparations

Dr. Pál Szilárd

23 Pharmaceutical capsules

Dr. Pál Szilárd

24 Pharmaceutical capsules

Dr. Pál Szilárd

25 Written test

Dr. Pál Szilárd

26 Written test

Dr. Pál Szilárd

27 Inhaled drug delivery systems

Dr. Pál Szilárd

28 Inhaled drug delivery systems

Dr. Pál Szilárd

Practices

Sugar and film coating process

End semester assessment

.

General instructions, rules and regulations on practices, introduction to solid forms

Undivided (bulk) powders, dusting powders, species I

Undivided (bulk) powders, dusting powders, species II

Divided powders I

Divided powders II

Dusting powders

Pills, hard gelatin capsules

Assessment

Preparation of garnules I, drying

Preparation of garnules II, examinations


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Tabletting I., Machines

Tabletting II., Direct compression

Seminars


The end-semester exam will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semesters, students take oral exam. The criterion of starting the oral exam is to pass a written „Minimum Test” (MT). To

write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in

MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to

unsatisfactory grade.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Nagy Sándor (NASMAAO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita

Judit (BORPAAO.PTE)


17

OPO-GOP PHARMACEUTICAL PATHOLOGY

Course director: DR. ZSOLT KOZMA, assistant professor

Department of Forensic Medicine

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 7


Course headcount limitations (min.-max.): 1 – 100 Prerequisites: OPO-A2S completed + OPO-EN2 completed

Topic

The subjects teaches the basics of pathology, and and pathology of organs for pharmacy students.



Mid-term exams

Oral exam.


Not possible.

Reading material



upload to Neptun

- Notes


Lectures

1 Introduction

Dr. Kozma Zsolt

2 Rules of Autopsy

Dr. Kozma Zsolt

3 Criteries of Death. Post-mortem changes.

Dr. Simon Gábor

4 Apoptosis. Necrosis.

Dr. Simon Gábor

5 Degeneration. Lipid and protein accumulation. Amyloidosis.

Dr. Simon Gábor

6 Atrophia, hyperplasia, hypertrophia.

Dr. Simon Gábor

7 Oedema, hyperaemia. Congestio. Bleeding.

Dr. Simon Gábor

8 Haemorrhagic diatheses, thrombosis, embolisation. DIC, Shock.

Dr. Simon Gábor

9 INjuries. Healing of the Wounnds

Dr. Simon Gábor

10 Vital signs and reactions

Dr. Simon Gábor

11 Acute and chronic inflammation

Dr. Kozma Zsolt

12 Foreign Body Reaction

Dr. Kozma Zsolt

13 Pathology of the cardiovascular system.

Dr. Simon Gábor

14 Atherosclerosis. hypertonia

Dr. Simon Gábor

15 Pathology of respiratory sytem

Dr. Kozma Zsolt


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16 Pathology of Intestinal tract. Pathology of urinary tract.

Dr. Kozma Zsolt

17 Pathology and Injuries of the central nervous system.

Dr. Kozma Zsolt

18 Pathology and Injuries of the central nervous system.

Dr. Kozma Zsolt

19 Pathology of Infectious Diseases

Dr. Kozma Zsolt

20 Envirormental Hazards

Dr. Kozma Zsolt

21 Benign and Malignant Tumors

Dr. Simon Gábor

22 Benign and Malignant Tumors

Dr. Simon Gábor

23 Posonngs.

Dr. Mayer Mátyás

24 Effects of alcohol.

Dr. Mayer Mátyás

25 Drug overdose

Dr. Simon Gábor

26 Drug Overdose

Dr. Simon Gábor

27 Pathology of poisonings

Dr. Simon Gábor

28 Forensic histopathology

Dr. Simon Gábor

Practices

Seminars


1. Post-mortem changes.

2. Apoptosis. Necrosis.

3. Atrophia, hyperplasia, hypertrophia.

4. Oedema, hyperaemia. Congestio. Bleeding.

5. Haemorrhagic diatheses, thrombosis, embolisation. DIC.

6. Shock.

7. Injuries. Healing of the wounds.

8. Vital signs and reactions. SG

9. Acute and chronic inflamamtion.

10. Pathology of the cardiovascular system.

11. Pathology of the respiratory system.

12. Pathology of the intestinal tract.

13. Pathology of the urinary tract.

14. Pathology and injuries to the central nervous system.

15. Benign and malingant tumors.

16. Drug overdose. Detection methods.

17. Forensic histopathology.

Participants


19

OPO-KE1 PUBLIC HEALTH 1

Course director: DR. ISTVÁN KISS, professor

Department of Public Health Medicine

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 7


Course headcount limitations (min.-max.): 1 – 200 Prerequisites: OPO-EN2 completed + OPO-MA2 completed

Topic

Public Health represents the preventive side of medicine. The subject deals with primary, secondary and tertiary prevention of the most

challenging diseases of public health.

The aims are to exam the process of disease development and demonstrate the possibilities of prevention on individual and community

levels.


-

Mid-term exams


-

Reading material


Edit Paulik: Public Health and Preventive Medicine, Medicina Publishing House, Budapest 2013.


Educational material uploaded on Neptun.

- Notes


Lectures

0 Global overview of health status. Definition of health and disease. Health determinants.

Dr. Kiss István

0 Global overview of health status. Definition of health and disease. Health determinants.

Dr. Kiss István

0 History of public health. Scope of preventive medicine. Basics of disease prevention. Levels of prevention.

Dr. Kiss István

0 History of public health. Scope of preventive medicine. Basics of disease prevention. Levels of prevention.

Dr. Kiss István

0 Demography.

Dr. Horváth-Sarródi Andrea

0 Demography.

Dr. Horváth-Sarródi Andrea

0 Basics of epidemiology, epidemiological indicators. Main types of epidemiological studies.

Dr. Szabó István

0 Basics of epidemiology, epidemiological indicators. Main types of epidemiological studies.

Dr. Szabó István

0 Observational and experimental epidemiological studies.

Dr. Szabó István

0 Observational and experimental epidemiological studies.

Dr. Szabó István

0 Nutritional epidemiology 1.: Basics of nutrition. Healthy nutrition, dietary recommendations. Nutrition related diseases.

Dr. Szabó István

0 Nutritional epidemiology 1.: Basics of nutrition. Healthy nutrition, dietary recommendations. Nutrition related diseases.

Dr. Szabó István


20

0 Nutritional epidemiology 2.: Nutritional habits, fad diets.

Dr. Kiss István

0 Nutritional epidemiology 2.: Nutritional habits, fad diets.

Dr. Kiss István

0 Nutritional epidemiology 3. Role of diet in the development of major chronic non infectious diseases.

Dr. Kiss István

0 Nutritional epidemiology 3. Role of diet in the development of major chronic non infectious diseases.

Dr. Kiss István

0 Screening.

Dr. Szabó István

0 Screening.

Dr. Szabó István

0 Epidemiology of cardiovascular diseases.

Dr. Kiss István

0 Epidemiology of cardiovascular diseases.

Dr. Kiss István

0 Cancer epidemiology.

Dr. Kiss Zsuzsanna

0 Cancer epidemiology.

Dr. Kiss Zsuzsanna

0 Epidemiology of diabetes and obesity.

Epidemiology of osteoporosis.

Dr. Kiss István

0 Epidemiology of diabetes and obesity.

Epidemiology of osteoporosis.

Dr. Kiss István

0 Epidemiology of respiratory and gastrointestinal diseases.

Dr. Németh Katalin

0 Epidemiology of respiratory and gastrointestinal diseases.

Dr. Németh Katalin

0 Epidemiology of suicide, epidemiology of mental disorders.

Dr. Kiss István

0 Epidemiology of suicide, epidemiology of mental disorders.

Dr. Kiss István

Practices

Seminars


Questions of choice Public Health 1.

1. Global overview of health status.

2. Definition of health and disease. Health determinants.

3. History of public health. Scope of preventive medicine.

4. Basics of disease prevention. Levels of prevention.

5. Demography. Descriptive epidemiology.

6. Basics of epidemiology, epidemiological indicators.

7. Main types of epidemiological studies.

8. Observational epidemiological studies.

9. Experimental epidemiological studies.

10. Basics of nutrition. Nutritional habits.

11. Nutrition related diseases.

12. Healthy nutrition, dietary recommendations.

13. Role of diet in the development of major chronic non infectious diseases.

14. Screening.

15. Epidemiology of cardiovascular diseases.

16. Cancer epidemiology.

17. Epidemiology of diabetes.

18. Epidemiology of obesity.

19. Epidemiology of osteoporosis.


21

20. Epidemiology of respiratory diseases.

21. Epidemiology of gastrointestinal diseases.

22. Epidemiology of suicide, epidemiology of mental disorders.

Participants


22

OPG-GH2 PHARMACODYNAMICS 2

Course director: DR. BALÁZS FERENC NÉMETI, associate professor


4 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8


Course headcount limitations (min.-max.): 1 – 100 Prerequisites: OPG-GH1 completed

Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the pharmacy.

Important topics are pharmacology of the blood, pharmacology of histamine, serotonin and eicosanoids, pharmacology of the respiratory

tract and the gastrointestinal tract, pharmacology of the central nervous system. Drug abuse and dependence as well as non-steroidal anti-

inflammatory drugs will also be discussed.



Mid-term exams

Around the 11th week of the semester, a written test is the base of the judgement of performance. The test covers the subjects of seminar

classes of the first 10 weeks of the semester. Students are required to reach at least 60%. Should someone fail in reaching 60%, the

semester performance will not be accepted and the student cannot take the exam. On such occasion, students not reaching the required

60% on the first midterm test will have the possibility to improve their results one time by the end of the semester. On a final failure (that

is, after the improvement attempt), the student cannot take the exam.


There is no way to make up for missed lectures or seminars.

Reading material



- Notes


Rang, Dale, Ritter, Moore: Pharmacology, 8th edition, Elsevier Churchill Livingstone, 2015

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012

Lectures

1 Drugs used to treat hyperlipoproteinaemias I

Dr. Poór Miklós

2 Drugs used to treat hyperlipoproteinaemias II

Dr. Poór Miklós

3 Drugs affecting haemostasis I

Dr. Poór Miklós

4 Drugs affecting haemostasis II

Dr. Poór Miklós

5 Drugs affecting haemostasis III

Dr. Poór Miklós

6 Drugs affecting haemostasis IV

Dr. Poór Miklós

7 Drugs affecting haematopoiesis I

Dr. Poór Miklós

8 Drugs affecting haematopoiesis II

Dr. Poór Miklós

9 Introduction into the pharmacology of the central nervous system I

Dr. Barthó Loránd

10 Introduction into the pharmacology of the central nervous system II

Dr. Barthó Loránd


23

11 Antianxiety and hypnotic drugs I

Dr. Poór Miklós

12 Antianxiety and hypnotic drugs II

Dr. Poór Miklós

13 Pharmacology of alcohols I


14 Pharmacology of alcohols II


15 Antipsychotic drugs I


16 Antipsychotic drugs II


17 Antidepressants I

Sánticsné Dr. Pintér Erika

18 Antidepressants II

Sánticsné Dr. Pintér Erika

19 Antiepileptic drugs I

Dr. Pethő Gábor

20 Antiepileptic drugs II. Centrally-acting muscle relaxants

Dr. Pethő Gábor

21 Opioid analgesic drugs I


22 Opioid analgesic drugs II


23 Opioid analgesic drugs III


24 Opioid analgesic drugs IV


25 Non-steroidal antiinflammatory drugs I

Dr. Pethő Gábor

26 Non-steroidal antiinflammatory drugs II

Dr. Pethő Gábor

27 Non-steroidal antiinflammatory drugs III

Dr. Pethő Gábor

28 Adjuvant analgesics. Drugs used to treat gout

Dr. Pethő Gábor

Practices

Seminars

1 Histamine, H1 receptor antagonists

2 H2 receptor antagonists

3 Serotonin, serotonin receptor agonists

4 Serotonin receptor antagonists

5 Pharmacology of eicosanoids

6 Drugs acting on the smooth muscle including uterine muscle

7 Pharmacology of the respiratory tract I

8 Pharmacology of the respiratory tract II

9 Pharmacology of the respiratory tract III

10 Pharmacology of the respiratory tract IV

11 Pharmacology of the gastrointestinal tract I

12 Pharmacology of the gastrointestinal tract II

13 Pharmacology of the gastrointestinal tract III

14 Pharmacology of the gastrointestinal tract IV

15 Pharmacology of the gastrointestinal tract V

16 Pharmacology of the gastrointestinal tract VI

17 General anaesthetics I

18 General anaesthetics II


24

19 Drug treatment of neurodegenerative disorders I

20 Drug treatment of neurodegenerative disorders II

21 Central nervous system stimulants I

22 Central nervous system stimulants II. Nootropic drugs

23 Drug abuse I

24 Drug abuse II

25 Drug abuse III

26 Drug abuse IV

27 Harmful effects of drugs and their mechanisms I

28 Harmful effects of drugs and their mechanisms II


Reqirements: the exams are oral, the required topics are dealt with during the semester lectures and seminars.

Exam questions:

1. Antianxiety and hypnotic drugs

2. Alcohols: pharmacology, toxicology

3. Antipsychotic drugs

4. Antidepressants

5. Central nervous system stimulants. Nootropic drugs

6. Drug treatment of neurodegenerative disorders

7. General anaesthetics

8. Antiepileptic drugs

9. Opioid analgesic drugs: morphine and codeine

10. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists

11. Non-steroidal antiinflammatory drugs: aspirin, paracetamol

12. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol

13. Adjuvant analgesics. Drugs used for treating gout. Centrally-acting muscle relaxants

14. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants

15. Drugs used for treating hyperlipoproteinaemias

16. Drugs affecting haemostasis

17. Drugs affecting haematopoiesis

18. Histamine, H1 and H2 receptor antagonists

19. Serotonin, serotonin receptor agonists and antagonists

20. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine muscle

21. Drugs used in bronchial asthma

22. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents

23. Drugs used in the treatment of peptic ulcer

24. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis

25. Laxatives, antidiarrheal agents, drug treatment of inflammatory bowel diseases

26. Harmful effects of drugs and their mechanisms

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the

student.

Participants

Bálint Mónika Enikő (E4CS9B), Dr. Poór Miklós (POMNAAO.PTE), Sánticsné Dr. Pintér Erika (PIEMAAO.PTE)


25

OPG-GI3 PHARMACEUTICAL PRACTICE AND MANAGEMENT 2

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy

5 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8



Prerequisites: OPG-GI2 completed + OPG-GH1 completed + OPG-GT3 completed

Topic

The topic of the semester primarily is to introduce the basic function of the health care system and pharmaceutical supply chain; in respect

of general legal, pharmaceutical, economical, marketing relations and specialties. Fundamentals of health economics and

pharmaeconomics essential for pharmacists are core elements of the semester. Basic and specific concepts of pharmaceutical care are

discussed in detail. Introduction to the basic tasks and services in hospital and clinical pharmacy are covered to support pharmacists;

clinical knowledge. Development of legal norms, hierarchy of norms, patients’ rights, claim for damages and other legislative aspects of

pharmacy practice are introduced in this semester. Lectures will cover basic knowledge regarding marketing and specific issues in

marketing for pharmacists. Interactive discussions will cover further topics regarding self-medication and over the counter medications

used in minor diseases. Students will improve pharmaceutical communication skills in order to counsel patients more efficiently,

collaborate with healthcare professionals and improve medication adherence.

Methods of comprehensive analysis, evaluation and development of drug therapy, the framework and regulation of pharmaceutical supply

system will be covered throughout the semester. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures are to

consolidate students; legal, marketing and pharmacoeconomical knowledge (pharmaceutical management, health economy,

pharmaceutical supply, pharmacoeconomy, evidence based medicine and pharmaceutics), and to lay the foundations of practical

pharmaceutical work and further professional development. Interactive group work during the seminars will encourage problem solving

skills and creative thinking.

Aims of lectures in pharmaceutical studies: Basic aim of these studies is to solidify pharmacy practice and related economic, clinical,

pharmaceutical care, communicational, marketing knowledge in order to understand pharmacoeconomics, drug allocation,

pharmaceutical management, health economics, evidence based medicine and in general pharmaceutics. This knowledge will support

later studies in these fields. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional

studies. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills. Topics

discussed during the lectures, but not included in the notes/books will also be included in the exams. Students can access the slides of

the lectures and further reading material on a designated web based interface (Neptun Meet Street).


- Regular attendance of classes/lectures (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- The mid-term and end-of-the-term test(s) should be passed (60,1%, minimum grade 2).

Mid-term exams

End-of-semester grade is given by end-of-the-term test’s result, any tests written throughout the semester and student performance during

the semester.

Examination and granting of grades: for Pharmaceutical Practice and Management 1 and 2 the end-of-the term test’s grade may be

accepted as an examination grade if passed.




Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun MeetStreet.

- Notes


Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, 6th edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012.

Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, 17th edition, American Pharmacists Association,

2012.

Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

John P. Griffin, John Posner, Geoffrey R. Barker: The Textbook of Pharmaceutical Medicine, 7th Edition, 2013.


26

Lectures

1 Communication: Strategies to meet specific needs 1


2 Communication: Strategies to meet specific needs 2


3 Introduction to the hospital and clinical pharmacy 1


4 Introduction to the hospital and clinical pharmacy 2


5 Communication skills in hospital practice


6 Electronic communication is healthcare, pharmacists in the social media


7 Hospital pharmacy services 1


8 Hospital pharmacy services 2


9 Helping patients manage therapeutic regimens. Supporting behaviour change


10 Ethical behaviour and assertiveness in communication


11 Adherence 1


12 Adherence 2


13 Interactive discussion and comparative evaluation of different Health Care Systems 1.


14 Interactive discussion and comparative evaluation of different Health Care Systems 2.


15 International Health Organizations


16 Hungarian and International Pharmaceutical Organizations


17 Fundamentals of Health Economics, Health Policy


18 Fundamentals and legal basic terms

Dr. Mohay Ágoston Csanád

19 Constitution, Acts, Laws, Regulations, Directives


20 Patient rights, obligations


21 Health care professional rights and obligations


22 Claim for damages


23 European Union


24 Impact of regulation of Community Pharmacies on efficiency, access and equity


25 The Costs of Health Care, the Benefits of Health Care


26 Health Expenditures, Prices of Drugs/Health Care Services, Cost Control Techniques


27 Placebo


28 Test

Dr. Botz Lajos


27

Practices

1 Pharmaceutical Care: evolution, principles

2 Pharmaceutical Care: feasibility and technique, legal framework, levels

3 Pharmaceutical Care: Special populations

4 Pharmaceutical Care: Asthma. Allergic rhinitis, COPD 1

5 Pharmaceutical Care: Asthma. Allergic rhinitis, COPD 2

6 Definition and history of marketing

7 The pharmaceutical and healthcare market

8 Decision Analysis

9 Decision Tree

10 Drug Utilization Studies

11 Quality of Life

12 Marketing mix, Motivation of the customer

13 Trademarks, brand building

14 Life cycle management, Product strategies

15 Price strategies, Distribution

16 Advertising medicines

17 Placebo 2

18 Test

Seminars

1 Insect bites, stings, Tics, Scabies, Pediculosis

2 Oral pain and discomfort, herpes labialis, aphthous stomatitis

3 Ophthalmic disorders, contact lenses

4 Optic disorders, vertigo

5 Prevention of pregnancy, pregnancy tests and STD-s

6 Vitamins, nutrition and drug therapy during pregnancy

7 Diaper dermatitis

8 Musculoskeletal injuries and disorders

9 Menstruation, biliary and urinary stones

10 Drowsiness and fatigue

11 Benign Prostatic Hyperplasia

12 Scaly dermatosis, dandruff

13 Pharmaceutical Care: Metabolic syndrome

14 Pharmaceutical Care: Hypertension

15 Pharmaceutical Care: Diabetes mellitus

16 Pharmaceutical Care: Dyslipidemia

17 Pharmaceutical Care: Devices

18 Main Pharmacoeconomic Evaluations 1. Theoretical

19 Main Pharmacoeconomic Evaluations 2. Practical

20 Decision Tree. Practical

21 Quality of Life. Practical

22 SOJA

23 SWOT analysis, BCG matrix

24 Test


Based on the topics of the lectures and seminars.

Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Télessy István (TEIQAAP.PTE), Dr. Végh Anna

(VEAOABO.PTE), Dr. Vida Róbert György (VIRNAAO.PTE)


28

OPG-GK4 PHARMACEUTICAL CHEMISTRY 4

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry

6 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8


Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GK3 completed

Topic

Introduction to quality control of complex preparations. Application of instrumental methods in pharmacopoeal quality control of

pharmaceutical preparations. Introduction of molecular aspects and structure activity relationship of selected groups of active

pharmaceutical ingredients.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written

during the semester on the 7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after

both tests. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical

work (results of the written tests and the experimental work) is evaluated by a practice grade. Satisfactory (2) evaluation is the minimum

requirement of acknowledgement of the semester.

Mid-term exams


There is no opportunity to make up missed classes.

Reading material


D.A. Williams, T.L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins,

Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic

educational material, PTE 2014

- Notes

Pharmaceutical Chemistry Practice 1, Laboratory manual, University of Pécs, 2015


European Pharmacopoeia. EDQM Publication

Lecture notes

Lectures

1 Introduction to separation techniques.

Dr. Perjési Pál

2 Introduction to separation techniques.

Dr. Perjési Pál

3 Application of GC in pharmaceutical analysis.

Dr. Kuzma Mónika

4 Application of GC in pharmaceutical analysis.

Dr. Kuzma Mónika

5 Application of TLC in pharmaceutical analysis.

Kulcsár Győző

6 Application of TLC in pharmaceutical analysis.

Kulcsár Győző

7 Application of HPLC in pharmaceutical analysis.

Dr. Kuzma Mónika

8 Application of HPLC in pharmaceutical analysis.

Dr. Kuzma Mónika

9 Application of gel chromatography in pharmaceutical analysis.

Dr. Almási Attila


29

10 Application of affinity chromatography in pharmaceutical analysis.

Dr. Almási Attila

11 Vitamins I.

Dr. Almási Attila

12 Vitamins I.

Dr. Almási Attila

13 Vitamins II.

Dr. Almási Attila

14 Vitamins II.

Dr. Almási Attila

15 Antifungal drugs.

Dr. Lóránd Tamás

16 Antifungal drugs.

Dr. Lóránd Tamás

17 Antiparasitic agents.

Dr. Lóránd Tamás

18 Antiparasitic agents.

Dr. Lóránd Tamás

19 Antimicrobial agents.

Dr. Lóránd Tamás

20 Antimicrobial agents.

Dr. Lóránd Tamás

21 Antibiotics I.

Dr. Lóránd Tamás

22 Antibiotics I.

Dr. Lóránd Tamás

23 Antibiotics II.

Dr. Lóránd Tamás

24 Antibiotics II.

Dr. Lóránd Tamás

25 Anticancer agents.

Dr. Perjési Pál

26 Anticancer agents.

Dr. Perjési Pál

27 Antiviral agents.

Dr. Perjési Pál

28 Antiviral agents.

Dr. Perjési Pál

Practices

1 Stereochemistry. The structure, the configuration and the conformation of molecules. (Hyperchem 4.0)




5 Application of mass spectrometry in pharmaceutical analysis. Principles of evaluation of mass spectra. Evaluation of mass spectra








9 Bases of chromatographic separations. Application of gas chromatography. Detection of methanol in ethanol by TLC and GC

methods.


methods.


methods.


methods.


30

13 Gas chromatographic derivatization reactions. Analytics of steroid hormones. TLC identification of steroid hormones.

Determination of hydrocortisone using GC and UV-Vis methods.







17 Determination methods of partition coefficients. Determination of logP of MBB by thin-layer chromatographic technique.




21 Identification of multi-component drug mixtures I. General principles. Sample preparation. Determination of bases in drug

mixtures I. Pulvis antispasticus.







25 Identification of multi-component drug mixtures II. Determination of bases in drug mixtures II. Pulvis antidoloricus. Pulvis

astmaliticus. Pulvis codacetini. Application of HPLC.







29 1st Midterm Test. Identification of multi-component drug mixtures III. Determination of bases in drug mixtures III. Pulvis

cholagogus, Unguentum haemorrhoidale, Suppositorium analgeticum.







33 Identification of multi-component drug mixtures IV. Determination of acids in drug mixtures I. Spiritus iodosalicylatus, Spiritus

salicylatus cum resorcino.







37 Identification of multi-component drug mixtures V. Determination of acids in drug mixtures II. Pulvis chinacisalis c. vitamino

C, Pulvis somniferens.







41 Vitamines. Detremination of cyanocobalaminum by UV-Vis and HPLC methods.




45 Drug metabolism I-II. (Seminar)





31

49 2nd Midterm Test. In vivo and in vitro methods of drug metabolism studies I. In vitro study on metabolism of acetylsalicylic

acid.


acid.


acid.


acid.

53 In vivo and in vitro methods of drug metabolism studies II. Determination of glucuronide and sulfate conjugates of 4-nitrophenol

by HPLC.


by HPLC.


by HPLC.


by HPLC.

Seminars


Oral exam covering the topics of Pharmaceutical Chemistry I-IV. Before the exam each student should have a Minimum Requirement

Test of which result should be at least 80%.

Further details: www.gytsz.pte.hu

Participants

Nyúl Eszter (NYESAAO.PTE)

http://www.gytsz.pte.hu/


32

OPG-GT4 PHARMACEUTICAL TECHNOLOGY 4

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy

6 credit ▪ final exam ▪ Pharm. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8


Course headcount limitations (min.-max.): 1 – 80 Prerequisites: OPG-GT3 completed

Topic

In this semester solid dosage forms, theoretical introduction of granulation, tabletting and tablet coating is discussed. Quality control of

prepared dosage forms are also carried out such as disintegration, dissolution, tablet hardness test, etc. Aspects and work in industrial

pharmacy is also presented during this semester.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade. In case of

fulfilled 1-3 sections, the requirement of the accepted semester is to reach at least satisfactory grade.

Mid-term exams


Students must fulfil requirements determined by the Code of Studies and Examinations.

All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu

www.sciencedirect.com

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

1 Drug Delivery Systems 1

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

http://www.gytk.pte.hu/

http://www.sciencedirect.com/


33


Dr. Pál Szilárd


Dr. Pál Szilárd

9 Written test

Dr. Pál Szilárd

10 Written test

Dr. Pál Szilárd

11 Multiparticulate systems 1 (microcapsules, micropellets)

Dr. Pál Szilárd

12 Multiparticulate systems 1 (microcapsules, micropellets)

Dr. Pál Szilárd

13 Multiparticulate systems 2 (molecular dispersion, liposomes, dendrimers, kohleats, kvantum dots, nanotubes)

Dr. Pál Szilárd

14 Multiparticulate systems 2 (molecular dispersion, liposomes, dendrimers, kohleats, kvantum dots, nanotubes)

Dr. Pál Szilárd

15 Development of pharmaceutical dosage forms 1

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

19 Written test

Dr. Pál Szilárd

20 Written test

Dr. Pál Szilárd

21 Stability of preparations

Dr. Pál Szilárd

22 Stability of preparations

Dr. Pál Szilárd

23 Wrapping of pharmaceutical preparations

Dr. Pál Szilárd

24 Wrapping of pharmaceutical preparations

Dr. Pál Szilárd

25 Quality Assurance, GMP

Dr. Pál Szilárd

26 Quality Assurance, GMP

Dr. Pál Szilárd

27 Official approval, validation, reproducibility, process control

Dr. Pál Szilárd

28 Written test

Dr. Pál Szilárd

Practices

General instructions, rules and regulations on practices, solutions, nasal drops, ear drops

Emulsions, suspensions

Eye oinments, eyes drops, tea mixtures, decoctum, infusum

Ointments/creams/pastes/gels

Vaginal, rectal suppositories

Powders, pills, hard gelatin capsules

Personal assessment 1-7

End-semester assessment of practice


34

Seminars


After the semester the exam is a complex exam from all Pharmaceutical Technology 1-2-3-4 courses evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.The end-semester exam

will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semester, students take oral exam. Chance „B” and „C” are also oral exams, which is preceded by the „Minimum Test”

(MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less

than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to

unsatisfactory grade.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.

Participants

Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Rezesné dr. Börzsei Rita Judit (BORPAAO.PTE)


35

OPO-KE2 PUBLIC HEALTH 2

Course director: DR. ISTVÁN KISS, professor

Department of Public Health Medicine

3 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8


Course headcount limitations (min.-max.): 1 – 200 Prerequisites: OPO-KE1 completed

Topic

Public Health represents the preventive side of medicine. The subject deals with primary, secondary and tertiary prevention of the most

challenging diseases of public health.

The aims are to exam the process of disease development and demonstrate the possibilities of prevention on individual and community

levels.


Participation in practicals is obligatory which is registered.

Absences should not exceed 2x45 min. Otherwise signature of grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material


Edit Paulik: Public Health and Preventive Medicine, Medicina Publishing House, Budapest 2013.


Educational material uploaded on Neptun.

- Notes


Lectures

0 Health effects of alcohol consumption and smoking I.

Dr. Berényi Károly

0 Health effects of alcohol consumption and smoking II.

Dr. Berényi Károly

0 Global drug trends. Drug trends in Hungary I.

Dr. Szabó István

0 Global drug trends. Drug trends in Hungary II.

Dr. Szabó István

0 Basics of toxicology.

Dr. Szabó István

0 Epidemiology of poisoning; global trends.

Dr. Szabó István

0 Basics of occupational health.

!Dr. Tibold Antal

0 Health effects of mechanical, ergonomic and psychological factors.

!Dr. Tibold Antal

0 Occupational carcinogens I.

Dr. Kiss István

0 Occupational carcinogens II.

Dr. Kiss István

0 Basics of environmental health.

Dr. Varga Csaba

0 Environmental health; global trends.

Dr. Varga Csaba

0 Air pollution.

Dr. Szabó István


36

0 Health effects of dust exposure.

Dr. Szabó István

0 Water hygiene, soil pollution I.

Dr. Varga Csaba

0 Water hygiene, soil pollution II.

Dr. Varga Csaba

0 Basics of infectious diseases.

Dr. Németh Katalin

0 Epidemiology of infectious diseases: global situation.

Dr. Németh Katalin

0 Epidemiology of airborne diseases I.

Dr. Németh Katalin

0 Epidemiology of airborne diseases II.

Dr. Németh Katalin

0 Epidemiology of infectious diseases transmitted by food and water I.

Dr. Németh Katalin

0 Epidemiology of infectious diseases transmitted by food and water II.

Dr. Németh Katalin

0 Epidemiology of sexually transmitted diseases.

Marek Erika

0 Hepatitis

Marek Erika

0 Haematogenic and lymphogenic infections. Epidemiology of infections transmitted through the skin.

Dr. Németh Katalin

0 Epidemiology of zoonoses.

Dr. Németh Katalin

0 Prion diseases. New infectious diseases.

Dr. Varga Csaba

0 Public health methods in disasters. Chemical and biological weapons, (bio)terrorism.

Dr. Szabó István

Practices

0 Nosocomial infections; Disinfection and sterilization II.

0 Physical exposures I.

0 Physical exposures II.

0 General epidemiology; meta-analysis, systematic review, databases I.

0 General epidemiology; meta-analysis, systematic review, databases II.

0 Chemical and microbiological qualification of drinking water I.

0 Chemical and microbiological qualification of drinking water II.

0 Genotoxicity laboratory practical I.

0 Genotoxicity laboratory practical II.

0 Chemical safety, risk assessment I.

0 Chemical safety, risk assessment II.

0 Vaccination, vaccination schedule I.

0 Vaccination, vaccination schedule II.

0 Nosocomial infections; Disinfection and sterilization I.

Seminars


1. Primary and secondary factors of epidemic process (virulence, source of infection, means of transmission, susceptible host)

2. Nosocomial infections. Sterilization, disinfection

3. Infectious diseases worldwide

4. Prevention of infectious diseases: vaccination, chemoprophylaxis

5. Epidemiology and prevention of vaccine-preventable diseases, mandatory immunisation for children

6. Epidemiology and prevention of airborne bacterial infections

7. Epidemiology and prevention of airborne viral infections

8. Characteristics, types, occurrence and prevention of enteric infections

9. Epidemiology and prevention of enteric bacterial infections

10. Epidemiology and prevention of enteric viral infections


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11. Epidemiology and prevention of enteric helminth and protozoon infections

12. Epidemiology and prevention of viral hepatitides

13. Epidemiology and prevention of haematogenic and lymphogenic infections

14. Epidemiology and prevention of infections transmitted through the skin

15. Epidemiology and prevention of zoonotic helminth and bacterial infections

16. Epidemiology and prevention of zoonotic protozoon and viral infections

17. Epidemiology and prevention of sexually transmitted diseases (excluding AIDS)

18. Epidemiology and prevention of AIDS

19. Epidemiology and prevention of prion diseases

20. New infectious diseases. Bioterrorism

21. Epidemiology and prevention of addictions

22. Criteria of the meta-analyses and the systematic review

23. Basic principles of ecology. Human environment, human ecology.

24. Settlement health, transportation and health, Health effects of interiors, health and the built environment

25. Environmental monitoring and protection. Health effects of global environmental issues

26. Air pollutants and their health effects

27. Health effects of microbiological and chemical water pollutants, water quality testing

28. Health effects of soil contamination. Health effects and management of waste water, wastes and hazardous wastes

29. History of occupational health. Organization and levels of occupational health services. Work safety

30. Risk assessment, management and communication

31. Occupational toxicology: chemical safety

32. Occupational cancers

33. Physical hazards: health effects of low and high temperature

34. Physical hazards: disorders caused by noise and vibration and their prevention

35. Chemical hazards: Industrial and agricultural toxicology of organic compounds

36. Chemical hazards: Industrial and agricultural toxicology of inorganic compounds

37. Psychosocial and biological hazards. Ergonomic factors.

38. Health effects of ionizing and non-ionizing radiations

39. Health effects of inorganic and organic dusts and their prevention

40. New and emerging risks in occupational medicine

41. Occupational diseases of health care workers and prevention. Occupational accidents.

42. Migration and catastrophes, medical and occupational health considerations

Participants

Dr. Gyöngyi Zoltán (GYZMAAO.PTE), Dr. Szabó István (SZIGABO.PTE), Dr. Szendi Katalin (SZKFAPO.PTE), Dr. Varga Csaba

(VACMAAO.PTE)


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OPO-KL1 CLINICAL STUDIES 1

Course director: DR. ERIKA SÁNTICS-PINTÉR, professor


2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ spring semester ▪ recommended semester: 8


Course headcount limitations (min.-max.): 2 – 40 Prerequisites: OPA-GA2 completed + OPO-EN2 completed

Topic

The task of the subject is the transmission of the most fundamental knowledge of the clinical studies for the pharmacy students. The

curriculum covers the most important diseases focusing on their pharmacotherapy. The task of this subject to promote the accurate

knowledge pharmacotherapy in the clinical practise.



Mid-term exams


None

Reading material



Lecture notes

- Notes


Lectures

1 Basic principles of medication of internal diseases

Dr. Cziráki Attila

2 Basic principles of medication of internal diseases

Dr. Cziráki Attila

3 Cardiology

Dr. Magyar Klára

4 Cardiology

Dr. Magyar Klára

5 Gastroenterology

Dr. Fábián György

6 Gastroenterology

Dr. Fábián György

7 Hepatology

Dr. Pár Alajos

8 Hepatology

Dr. Pár Alajos

9 Nephrology

Dr. Nagy Judit

10 Nephrology

Dr. Nagy Judit

11 Metabolism - Diabetology

Dr. Wittmann István

12 Hypertension

Dr. Kovács Tibor József

13 Hematology

Dr. Kosztolányi Szabolcs

14 Hematology

Dr. Kosztolányi Szabolcs


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15 Pulmonology

Dr. Illés Miklós Balázs

16 Pulmonology

Dr. Illés Miklós Balázs

17 Survey of the endocronological diseases

Dr. Nemes Orsolya

18 Survey of the endocronological diseases

Dr. Nemes Orsolya

19 Infectology

Dr. Péterfi Zoltán

20 Infectology

Dr. Péterfi Zoltán

21 Surgery of the esophagus and the stomach

Dr. Papp András

22 Surgery of the esophagus and the stomach

Dr. Papp András

23 Transplantation

Dr. Szakály Péter

24 Transplantation

Dr. Szakály Péter

25 Thoracic surgery

Dr. Szántó Zalán János

26 Coloproctological surgery

Dr. Baracs József

27 Surgery of the pancreas

Dr. Kelemen Dezső Tamás

28 Surgery of the liver

Dr. Papp András

Practices

Seminars


Written exam based on the lectures.

Participants

STUDY PROGRAM 2017/2018 Subjects of the 7-8. semesters … · 2017-08-10 · Drugs acting on...

Documents

Transcript of STUDY PROGRAM 2017/2018 Subjects of the 7-8. semesters … · 2017-08-10 · Drugs acting on...