Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with...
-
Upload
reynard-blankenship -
Category
Documents
-
view
219 -
download
0
Transcript of Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with...
![Page 1: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/1.jpg)
Study Aids
• Anki Flash cards– Content that you need to know for the tests.
• MS Excel sheet with Calculations
![Page 2: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/2.jpg)
PHARMACOKINETIC BASICSLecture #2
![Page 3: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/3.jpg)
![Page 4: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/4.jpg)
Factors in Measuring Systemic Exposure
• Sites of Measurement (Where?)• Unbound [Drug]• Exposure-Time Profile• Observation Period
![Page 5: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/5.jpg)
Exposure-Time Profile
In addition to the concentration, what other factor should we consider with exposure?
![Page 6: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/6.jpg)
Sites of Measurement
• Invasive– Whole Blood, Plasma and Serum• Unbound Drug Concentration and Fraction Unbound
• Non-invasive– Breath– Milk– Saliva– Feces– Urine
![Page 7: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/7.jpg)
Chemical Purity/Enantiomers
anticoagulant
stimulant
Decreases Rapidly
[drug] very low
![Page 8: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/8.jpg)
Active Metabolites and Prodrugs
![Page 9: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/9.jpg)
Sites of Administration• Intravascular Systemic Circulation
– Intravenous (IV)– Intra-arterially (IA)
• Extravascular Absorption Systemic Circulation– Buccal (Between Cheek and Gum)– Intradermal (ID)– Intramuscular (IM)– Oral – Pulmonary (Inhalation)– Subcutaneous (Subcut, Fat under Skin)– Rectal– Sublingual (SL, under the tongue)
![Page 10: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/10.jpg)
Typical Exposure-Time Profiles
0 2 4 6 8 10 120
2
4
6
8
10
12
time (hr)
[Dru
g]pl
asm
a
Intravascular Extravascular
Lag due to absorption
[Dru
g]pl
asm
a
![Page 11: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/11.jpg)
Parenteral Administration
• Restricted to Injected– Intravascular– Intramuscular– Subcutaneous
![Page 12: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/12.jpg)
![Page 13: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/13.jpg)
How a drug ends up- Drug Disposition
(i.e. Amount Absorbed)
ExcretedMetabolite
![Page 14: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/14.jpg)
Terms
• Elimination– Drug Metabolism– Amount/time (mg/hr)
• Excretion– Drug Removal from the Body– Amount/time (mg/hr)
• Clearance– Volume/time (L/hr)
![Page 15: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/15.jpg)
D[Drug] = [Drug]in –[Drug]out
DDrugDrug In
Drug Out
![Page 16: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/16.jpg)
![Page 17: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/17.jpg)
Representing PK
• Equations• Physiologic Models• Compartment Models
![Page 18: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/18.jpg)
Equations
Why?
![Page 19: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/19.jpg)
Physiologic Models
![Page 20: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/20.jpg)
Compartmental Models
![Page 21: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/21.jpg)
ADME
![Page 22: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/22.jpg)
Systematic Absorption
First Pass Loss
Systemic Circulation
Bioavailability (F)
![Page 23: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/23.jpg)
Enterohepatic Cycle: Drugs Recycled
![Page 24: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/24.jpg)
PK Terms
• Maximum Concentration (Cmax)
• Maximum Time (tmax)• Area Under the Curve (AUC)
![Page 25: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/25.jpg)
Cmax and tmax
Cmax
tmax
![Page 26: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/26.jpg)
What factors determine how much exposure that you have to a “poison”?
• systemic exposure = How long * How much[D
rug]
plas
ma
time
Systemic Exposure
How longHow
much
![Page 27: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/27.jpg)
What factors determine how much exposure that you have to a drug?
• AUC = How long * How much[D
rug]
plas
ma
time
Area Under the Curve (AUC)
How longHow
much
![Page 28: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/28.jpg)
Area Under the Curve (AUC)
tmax
AUC(µg/L)*hr
![Page 29: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/29.jpg)
Area Under the Curve
![Page 30: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/30.jpg)
Drug Plasma After Intravenous (IV) Bolus Dose
0 2 4 6 8 10 120
2
4
6
8
10
12
time (hr)
[Dru
g]pl
asm
a
C(0)
k=rate (/hr)
![Page 31: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/31.jpg)
Drug Plasma After Intravenous (IV) Bolus Dose
0 2 4 6 8 10 120
2
4
6
8
10
12
time (hr)
[Dru
g]pl
asm
a
C(0)
AUC
Cmax and tmax?
![Page 32: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/32.jpg)
Trapezoid Area
a b
c
![Page 33: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/33.jpg)
Trapezoid AreaCi
tfti
Cf
time
[Dru
g]
![Page 34: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/34.jpg)
Drug Plasma After Intravenous (IV) Bolus Dose
0 2 4 6 8 10 120
2
4
6
8
10
12
time (hr)
[Dru
g]pl
asm
a
C(0)
![Page 35: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/35.jpg)
Drug Plasma After Intravenous (IV) Bolus Dose
0 2 4 6 8 10 120
2
4
6
8
10
12
time (hr)
[Dru
g]pl
asm
a
C(0)
Ct
![Page 36: Study Aids Anki Flash cards Content that you need to know for the tests. MS Excel sheet with Calculations.](https://reader034.fdocuments.in/reader034/viewer/2022051305/5a4d1b817f8b9ab0599bb21d/html5/thumbnails/36.jpg)
Drug Plasma After Intravenous (IV) Bolus Dose Only
0 2 4 6 8 10 120
2
4
6
8
10
12
time (hr)
[Dru
g]pl
asm
a
C(0)
Only works when the curve is shaped like this.