Structure for Tissue Engineering Research while Writing a Detailed Research Proposal- Tutors India
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Copyright © 2020 TutorsIndia. All rights reserved 1
Structure for Tissue Engineering Research While Writing a Detailed
Research Proposal
Dr. Nancy Agens, Head,
Technical Operations, Tutorsindia
info@ tutorsindia.com
In Brief
Writing a research proposal is the
foremost task towards accomplishing the
completion of a research project. Though
the format of research proposals for
different domains is similar but there is a
huge variation in the content and its style
Considering writing a research proposal
for tissue engineering or medical domain
it is imperative to mention the key
constructs such as benefits,
advancements etc.
I. INTRODUCTION
As defined earlier a research proposal
holds paramount significance for
successful completion of a research
project. However, it is not merely a
proposal but also a source of funding. In
this case it is necessary that the proposal
follows certain word length, a well-defined
structure and layout. A general layout for a
research proposal is as follows:
Title
Introduction
Aims and objectives
Literature review
While the aforementioned format is
suitable for most of the research works of
different domains it is also adjustable for
medical domain but there have to be
included certain content that justifies the
work. For example, if the research project
is related to advancement in surgery
techniques then it becomes inevitable to
describe in brief the difference between
classical techniques and contemporary
approaches. In addition it also noteworthy
that the individual should have a clear
vision of the approach being implemented
or discussed in his project so as to avoid
any confusion. Since here the plan for a
research proposal for tissue engineering
domain is being discussed hence a snippet
of the key constructs required for writing a
proposal are discussed.
While writing a research proposal
for tissue engineering an individual should
begin with describing the role of tissue
engineering, its significance and its
superiority over classical techniques that
are being followed. An individual can
begin with description of tissue
engineering. For example, tissue
engineering can be defined as a process in
which a biological alternative is focused
on for conserving the structure and
function of tissue. The field of tissue
engineering can be called as
interdisciplinary since it integrates both
engineering as well as life sciences. In the
initial stage the tissue engineering practice
was adopted near 1980 when skin
regeneration was enabled by using the
cells in collagen gels. With the passage of
time and advancements in research the
tissue engineering approach developed.
The author explored the application of
tissue engineering for regenerating the
mandible and showed optimal results. In
some prominent works the researchers
have given a brief idea of the different
components of tissue engineering and their
significance.
It has been asserted through
different works that tissue engineering
refers to creating tissues by integrating
scaffolds, cells or bioactive molecules.
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In the introduction part of the
research proposal some key points should
be mandatorily included. For example in
case of tissue engineering it should be
mentioned that the tem was put forward to
the scientific community by Langer and
Vacanti. Similarly the key works
performed towards the proposed research
work should be mentioned and also the
drawbacks of the approaches followed in
those works should be discussed clearly.
Finally presenting a brief
evaluation of the different research works,
the proposed approach should be
mentioned. It should clearly define its
efficacy over other approaches performed.
In the further sections of the research
proposal a snippet of the technique being
implemented should be provided so that
the reviewer can understand the purpose of
research and its significance towards the
society. In addition it will also help
reviewer to gain confidence about the
funding of project. As mentioned
previously there are some key questions
that need to be addressed while writing a
research proposal for tissue engineering. A
snippet of these is given as follows.
II. NEED OF TISSUE ENGINEERING
Tissue engineering (TE) has
revolutionised the field of medicine with
its high efficacy and aid towards repairing
and developing tissues that have been
damaged due to any accident or illness. In
the present scenario transplantation, use of
mechanical devices is being widely
employed which undeniably cause certain
issues. TE aims to alleviate these issues
and ensure smooth functioning. Though
these approaches have been a boon for
numerous individuals but they have been
imposing certain problems such as lack of
suitable donor during transplantation,
higher risk of organ failure during
transplantation etc. Similarly, issues
associated with surgeries have also been
found to be impacting health of
individuals. Thus TE serves as a promising
solution towards resolving these problems.
III. SUCCESS OF TISSUE
ENGINEERING
Since TE is a multidisciplinary
approach involving engineering as well as
biological techniques towards betterment
of society. The skin TE approach is being
practiced since long and has been
exhibiting success. Considering the
success it is now being explored to a
greater extent by the practitioners with the
motive of benefitting the society.
The damage of tissues is a common
problem but the regeneration of these
tissues is possible only up to a certain age.
Beyond this age the regeneration process
either slows down or stops completely
causing severe pains and other allied
issues. It is then that TE can be applied.
IV. PROCESS OF TISSUE
ENGINEERING
The process of TE can be explained
through the graphical illustration shown
below. It can be observed from the
illustration that initially the cells are
separated from a source followed by
expansion in a cell culture system. They
are then embedded onto a carrier which in
addition to a proper medium imparts
structural support. In this phase the cells
move to the carrier and substitute the old
tissues with the new tissues forming.
Besides these points it is necessary
to mention the sample size and technique
being used followed by conclusion. A
research proposal planned and designed in
such a way would ensure success in unison
with timely completion of the project.
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Copyright © 2020 TutorsIndia. All rights reserved 2
V. CONCLUSION
Writing a research proposal for
tissue engineering is a critical task as it
involves sharing different aspects related
to the research that is being planned by an
individual. However, a proper planning
and design of the research can assure
success. Also it is imperative that while
preparing a research proposal one should
include all the key points that would be
helpful for the reviewer to understand the
research. The researcher should also
provide a conclusion which discusses the
future scope of the approach applied in
addition to its benefits and application in
present situation.
REFERENCES
1. Hernandez F,Ruiz-Magnaz V,Guijarro-Martinez R.
Mandible reconstruction with tissue engineering in
Multiple Recurrent Ameloblastom Int J Periodontics
and Restorative Dent 2012
2. Waranke PH ,Springer IN, Wiltfang J et. Al.
Growth and transplantation of a custom vascularized
bone graft in man The Lancet,2004;364:766-770
3. Ghosh, Bikramaditya & Pal, Imon. (2016). Basic
Ideas and Concepts about Tissue engineering: A
Review. International Journal of Scientific and
Engineering Research. 7.
4. Castells-Sala C, Alemany-Ribes M, Fernandez-
Muiños T, RechaSancho L, Lopez-Chicon P et al.
(2013) Current Applications of Tissue Engineering
in Biomedicine. J Biochip Tissue chip S2: 004.
5. Langer R, Vacanti J P (1993) Tissue Engineering.
Science 260: 920-926.
6. Thomas, David & Hodges, Ian. (2010). Chapter 13
Writing a Research Report: Organisation and
presentation.
7. Johnstone, Brian, Mauro Alini, Magali Cucchiarini,
George R. Dodge, David Eglin, Farshid Guilak,
Henning Madry et al. “Tissue engineering for
articular cartilage repair-the state of the art.”-
European Cell & Materials-25 (2013): 248-267.