8/17/2019 STRUCTURAL MOTIFS OF TRANSCRIPTIONAL REGULATORS

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Gclsjlr Aleau`y

_c.I., D.V.^n., G.V.^n. & L.C.

^YW]NY]WL@ DKYB^

K YWL!^NWB_YBK!L@W"A]@LYKW^

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 Ycm IEL-gbeibea ikdlbes kf mujlryktbn

lntbvltkrs lei rmprmsskrs nketlbe lvlrbmty kf strunturl` dktbfs tclt gbei

spmnbn IEL smqumenms. Ycm lgb`bty kf

IEL-gbeibea prktmbes tk gbei tk spmnbnIEL smqumenms nkddke`y rmsu`ts frkdeke-nkvl`met betmrlntbkes gmtwmme ltkds

be le cm`b! be tcm IEL-gbeibea ikdlbelei ltkds ke tcm miams kf tcm glsmswbtcbe l dl"kr arkkvm be tcm IEL.

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C#`$%'urec#`$% D('$) 

• #ley glntmrbl` rmprmsskrs lrm ibdmrbn

prktmbes be wcbnc le cm`b! frkd mlncdkekdmr besmrts betk l dl"kr arkkvm betcm IEL cm`b!$ tcm ldbek lnbi sbim nclbestclt nketlnt IEL m!tmei frkd tcbs cm`b!.

•  Ycbs cm`b! bs rmfmrrmi tk ls tcmrmnkaebtbke cm`b! kr smqumenm-rmlibeacm`b!.

•  Ycm rmnkaebtbke cm`b! bs usul``y suppkrtmibe tcm prktmbe strunturm be plrt gycyirkpckgbn betmrlntbkes wbtc l smnkei

cm`b! "ust E-tmrdbel` tk bt.

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*$en$ea#r _r('#$es

• L eudgmr kf ib%mrmet mujlryktbnprktmbes clvm rmabkes tclt fk`i lrkuei l

nmetrl` &e'( bke) prkiunbea l nkdplntikdlbe frkd l rm`ltbvm`y sckrt `meatc kftcm pk`ypmptbim nclbe.

•  Ywk n`lssms kf &e *beamr prktmbes m!bst)ekt l`` lrm trlesnrbptbkel` rmau`ltkrs.

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&ben-*beamr +rktmbes,

•  Ywk n`lssms

 „ Ycm '/' ?ben eamr bs tcm dkst nkddke IEL-gbeibea dktbf menkimi be tcm amekdms kf dkstktcmr du`tbnm``u`lr lebdl`s. Ycbs dktbf cls l'gmnlusm bt clsfkur nkesmrvmi nystmbems be nketlnt wbtc tcm&e'(9) bs fkuei be 613 cudle trlesnrbptbkeflntkrs$ ekw nkddke`y nl``mi eun`mlr

rmnmptkrs.

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@#un$e#*$++#r _r('#$es

•  Ycm IEL-gbeibea ikdlbes kf l `lram n`lss kf

trlesnrbptbke flntkrs nketlbes tcm cyirkpckgbnldbek lnbi `munbem lt mvmry smvmetc pksbtbke betcm smqumenm. Ycmsm prktmbes gbei tk IEL lsibdmrs) lei dutlamemsbs kf tcm `munbems

sckwmi tclt tcmy wmrm rmqubrmi fkribdmrb?ltbke.

•  Ycm ibdmrbn prktmbe nketlbes twk m!tmeimicm`bnms tclt 2arbp8 tcm IEL dk`mnu`m) dunc `bjm

l plbr kf snbsskrs) lt twk li"lnmet dl"kr arkkvmssmplrltmi gy lgkut cl`f l ture kf tcm ikug`mcm`b!. Ycm pkrtbkes kf tcm cm`bnms nketlntbea tcmIEL ben`uim glsbn rmsbiums tclt betmrlnt wbtc

pckspcltms be tcm IEL glnjgkem.

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C#`$%@((+C#`$% _r('#$es

•  Ycm IEL-gbeibea ikdlbe kf lektcmr

n`lss kf ibdmrbn trlesnrbptbke flntkrs

nketlbes l strunturl` dktbf vmry sbdb`lrtk tcm `munbem ?bppmr dktbf m!nmpt tclt leke-cm`bnl` `kkp kf tcm pk`ypmptbim

nclbe smplrltms twk -cm`bnl` rmabkes bemlnc dkekdmr.

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YCL! -K]