Structural and Computational Biophysics Training Program

Program Retreat for T32-GM095440April 24, 2015

Wake Forest Biotech PlaceRoom 155

External AdvisoryCommittee

LeCompte Estes

Program Administration

Co-DirectorsPoole Lyles

Executive CommitteePoole Lyles Salsbury King

TrainingFaculty

StudentTrainees

Advanced Courses in Structural and Computational Biophysics

Discipline-Specific Coursework

Program CurriculumMolecular and Cellular

Biosciences

MolecularMedicine

Biochemistry MolecularGenetics

Chemistry Physics

MCB 711Biological Systems

and Structures

PHY 607Biophysics

Center for Structural BiologySeminar Series

Structural and ComputationalBiophysics Discussion Group

Training in Responsible Conduct of Research

Training for a Diversity of Careers

• Career workshops• SCB-sponsored workshops• Shared workshops with Graduate School and other T32

training programs

• Courses• Principles and Practice of Teaching Biochemistry (BICM 717,

718)• Drug Discovery, Design, and Development - Molecules to

Medicines (CHM 740, also listed as BICM 740)

Training for a Diversity of Careers (cont.)

• Internships• Biotechnology (Targacept, Keranetics)• Pharma (GSK)• Tech Transfer (Wake Forest Innovations)• Intellectual Property (Kilpatrick Townsend & Stockton, LLP)

• Combined Degrees• Ph.D.-M.B.A.• M.D.-Ph.D.

Recruitment of Trainees

• Web-based recruiting and application

• Career Day at Wake Forest

• Campus visits

• Masters degree program• Mathematics, Computer Science, Physics, Chemistry,

Biomedical Science• Certificate Program in Structural and Computational

Biophysics

Recruitment of Members of Minority Groups Under-represented in Science

• Attendance at national meetings (NIGMS TWD, ABRCMS)

• Partnership with North Carolina A&T State University• Participation in MARC Program (T34-GM083980, Mary Smith,

PI)• Participation in BUILD grant application• Attendance at annual MORE-STEM fair• Research collaborations

• Participation in PREP Program (R25-GM064249, Debra Diz, PI)

Program Evaluation

• Student evaluations at annual committee meetings according to their Individual Development Plans

• Course evaluations by student surveys and by coordination with course directors

• Individual training program evaluations by anonymous exit interviews with the Dean of the Graduate School.

• External program reviews

Student Discussion Groups

Student GroupMacnamara 1Lawson 1Nilsson 1Mukherjee 1Godwin 1Mauney 2Wang 2Yang 2Xiao 2Dushime 2Davis 3Zahid 3Black 3Belanger 3Lucas 4Davidson 4Su 4Melvin 4

Student GroupLawson 1Mauney 1Dushime 1Belanger 1Melvin 1Macnamara 2Godwin 2Xiao 2Black 2Su 2Mukherjee 3Yang 3Zahid 3Davidson 3Nilsson 4Wang 4Davis 4Lucas 4

Session 1 Session

Recommendations of External Advisory Committee

• Inter-campus communication: course listing, transportation, internet access

• Training faculty size and composition

• Program cohesiveness and intellectual focus

• Curriculum and outcome evaluation

• Certificate Program and internships not widely understood

• Communication and interaction among students and faculty

• Value added

T32 GM095440: Structural and Computational Biophysics Training Program

Goal: To bridge the gap between biomedical sciences and more basic quantitative sciences

Interdisciplinary Research at WFU

COBCAPconsortium of biological chemistry and physics

(2002 retreat, 34 faculty across campuses)

• Translational Science Center• Center for Molecular

Communication and Signaling

applying chemical and physical theory and techniques to biological problems

• shared resources • combined seminars• cross-departmental teaching• cross-departmental research

opportunities

Dany Kim-Shapiro (Biophysics)

Interdisciplinary Research at WFU

COBCAPconsortium of biological chemistry and physics

(2002 retreat, 34 faculty across campuses)

Recruitment of Reynolds Professorin Computational Biophysics:

Jacquelyn Fetrow (Physics & CompSci)

Dany Kim-Shapiro (Biophysics)

Interdisciplinary Research at WFU

•Center for Structural Biology move to BGTC, near WFU

2003

2004

2006

20082011

2012

Bowman Gray Technical Center

Interdisciplinary Research at WFU

•Center for Structural Biology•GAANN grant application (Fetrow)•Structural and Computational Biophysics Journal Club

2003

2004

2006

20082011

2012

Interdisciplinary Research at WFU

2003

2004

2006

20082011

2012

•Center for Structural Biology•GAANN grant application (Fetrow)•Structural and Computational Biophysics Journal Club•DMS-NSF/NIGMS Mathematical Biology Initiative (Funded), 2005-2009 (redox biology/proteomics with mathematical modeling)•Certificate Program: Interdisciplinary Graduate Track in Structural and Computational Biophysics at Wake Forest University•Interdisciplinary Drug Discovery course (Hantgan)•Molecular and Cellular Biology unified curriculum for incoming Ph.D. stud•Predoctoral Training Program (T32) in Structural and Computational Biophysics (Lyles & Poole PIs, Salsbury & Fetrow, executive board)•CSB & Biochem, with Immunol/Microbiol, Phys/Pharm, Bioengineering, move to Biotechnology Place

Training Grant Award, 2011-2016

July 1, 2011, Start of Predoctoral T32 Training Grant (2 slots, then 4 slots/year)

Continued SCB Discussion Group, monthly at Foothills Brewery

August 25, 2014, External review of T32-GM095440 Juliette Lecomte, Johns HopkinsMary Estes, Baylor

April 24, 2015, SCB Retreat

May 25, 2015, Deadline to submit competitive renewal

Sept-Oct 2015, expected site visit before Nov. study section meeting

Training Grant Award, 2011-2016

2011-2012: Laura Dillon (Wang, Biochemistry, yr 5)Andrea Belanger (Kim-Shapiro, Physics, yr 2)

2012-2013: Andrea Belanger (Kim-Shapiro, Physics, yr 3)Chris Mauney (Hollis, Biochemistry, yr 2)Thomas Poole (King, Chemistry, yr 2)Amanda Smelser (Macosko, yr 2) ** NSF fellowship

2013-2014: Chris Mauney (Hollis, Biochemistry, yr 3)Thomas Poole (King, Chemistry, yr 3) ** GSK internshipJanelle Leuthaeuser (Fetrow, yr 4)Jade Mims (Furdui, yr 2)

2014-2015: Janelle Leuthaeuser (Fetrow, yr 5)Jade Mims (Furdui, yr 3)Reed Lawson (Lowther, yr 2)Ryan Godwin (Salsbury, yr 2)

Faculty in SCB Training ProgramDepartmental Affiliations

Internal MedicineSection on Molecular Medicine

Cristina Furdui

ToddLowther

DougLyles

Biochemistry

LesliePoole

FredPerrino

TomHollis

UliBierbach

BruceKing

Chemistry

DanyKim-

Shapiro

MartinGuthold

FredSalsbury

Jed Macosko

JacqueFetrow

Physics

Suzy TortiDave Horita

Yuh-Hwa Wang

Faculty in SCB Training Program

SCB Related Facilities

Cristina Furdui

ToddLowther

DougLyles

LesliePoole

FredPerrino

TomHollis

UliBierbach

BruceKing

DanyKim-

Shapiro

MartinGuthold

FredSalsbury

Jed Macosko

JacqueFetrow

Mass Spectrometry Triple Quad, Q-ToF, LTQ-Oribtrap (Velos & XE), MALDI-ToF

Xray diffractometersCSB: 1 generator,

2 detectors

Protein analysisAnalytical

Ultracentrifuge, SPR, DLS, Typhoon

scanner

SpectroscopyUV-Vis & Fluor, Stopped-flow

fluorimeter, time-resolved

fluorimeter, CD, EPR

Scanning Tunneling & Atomic Force

Microscopes, TEM, SEM, LSCM

Computational Resources

CSB Linux cluster and graphics facility, DEAC

cluster

Nanotechnology: NextGenSequencing

NMRBruker 300,

500 & 600 MHz

Interdisciplinary Research at WFU

COBCAP

Interdisciplinary Science CentersMedical Center:

Comprehensive Cancer CenterTranslational Science Institute (MMTS & MGG)

Reynolda Campus: Translational Science Center (to promote and maintain functional health in aging)Center for Molecular Communication and Signaling

•Center for Structural Biology (2003), new site at BGTC•GAANN grant application (Fall 2003)•Structural and Computational Biophysics Journal Club (Spring 2004)•DMS-NSF/NIGMS Mathematical Biology Initiative, (Fall 2004): 2005-2009 (redox biology and proteomics with mathematical modeling using computational algebra and Bayesian tools)•Curriculum changes to add advanced training in structural biology (2005), unified

basic curriculum for molecularly-oriented biomedical Ph.D. students (2006), Interdisciplinary Drug Discovery course (2008)•Certificate Program (2006): Interdisciplinary Graduate Track in Structural and Computational Biophysics at Wake Forest University•Predoctoral Training Program (T32) in Structural and Computational Biophysics (Lyles & Poole PIs, Salsbury & Fetrow, executive board)