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Transcript of STROKE SYNDROMES - uw.cloud-cme.com · PDF fileSTROKE SYNDROMES Andrew Huffer ... likelihood...
![Page 1: STROKE SYNDROMES - uw.cloud-cme.com · PDF fileSTROKE SYNDROMES Andrew Huffer ... likelihood of surviving with mRS≤4 if done within ... (Wallenberg) Syndrome •Vestibulocerebellar](https://reader030.fdocuments.in/reader030/viewer/2022020302/5aa237a47f8b9a07758cc1df/html5/thumbnails/1.jpg)
STROKE SYNDROMES
Andrew Huffer34th Annual Board Review Course in Physical Medicine & Rehabilitation
March 10, 2017
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Overview
• Cerebrovascular Anatomy• General Principles• Large Vessel Syndromes– Anterior Circulation– Posterior Circulation– Watershed Syndromes
• Lacunar Syndromes
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CEREBROVASCULAR ANATOMY
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Axial
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Coronal
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Sagittal
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GENERAL PRINCIPLES
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Stroke Type Typical Features Location Mechanism
Large Vessel Thromboembolic (50%)
• Stuttering or progressive hours-days• Perfusion dependent• Often during sleep
• Carotid bifurcation• ICA siphon• Proximal M1• Verterbral origin• Intracranial vertebral
• Atherosclerosis• Dissection• Radiation
Cardioembolic (25%)
• Sudden onset • Maximum at onset, improve quickly• Single or multiple vascular territories
Distal ICAM1/M2Gray/white junction
• Atrial fibrillation• Mechanical valve• Recent MI• Dilated cardiomyopathy
Lacunar (10%) • Sudden or gradual onset • Stuttering • Lack of cortical signs and symptoms
• Basal ganglia• Thalamus• Pons• Cerebellum
• Lipohyalinosis• HTN
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Stroke Type Typical Features Location Mechanism
Intraparenchymal Hemorrhage (10%)
• Progressive minutes-hours• Focal progressing to HA, N/V, somnolence, coma• Drugs, exertion, or other causes of HTN
• Basal ganglia• Thalamus• Pons• Cerebellum• Cortical
• HTN (Charcot-Bouchard aneurysm)• Cerebral amyloid angiopathy• AVM
Subarachnoid Hemorrhage (5%)
• Abrupt severe HA, neck pain, N/V, photophobia• focal neurological deficits less common• often have relevant family history
• Basal cisterns• Cerebral convexity
• Saccular aneurysm• CAA• AVM/DAVF
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LARGE VESSEL SYNDROMES
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Anterior Circulation Strokes
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Question
• A 78 year old develops painless vision loss in his right eye that he describes as a curtain coming down, lasting for 15 minutes. Which test is most likely to diagnose the cause of his symptoms?a. Brain MRIb. Carotid duplex ultrasoundc. Transthoracic echocardiogramd. 30 day cardiac rhythm monitor
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Question
• A 78 year old develops painless vision loss in his right eye that he describes as a curtain coming down, lasting for 15 minutes. Which test is most likely to diagnose the cause of his symptoms?a. Brain MRIb. Carotid duplex ultrasoundc. Transthoracic echocardiogramd. 30 day cardiac rhythm monitor
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Internal Carotid Artery
• Symptomatic stenosis– Hemodynamic: transient deficits with global
hypoperfusion or increased demand– Embolic: amaurosis fugax, other TIA or strokes– Progressive cognitive decline
• Dissection– Headache, carotidynia– Horner’s syndrome
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Anterior Choroidal Artery
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• Motor– Contralateral hemiparesis (posterior limb of
internal capsule)
• Sensory– Contralateral hemianesthesia (VPM of thalamus)
• Vision – Homonymous hemianopia (LGN of thalamus)
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Question
• A 76 year old with atrial fibrillation presents with reduced speech output, flat affect, and inability to walk. On exam she has minimal verbal output and cannot move either leg. What is the anatomic localization for her symptoms?a. Dominant inferior frontal lobe (Broca’s area)b. Dominant posterior superior temporal lobe
(Wernicke’s area)c. Bilateral medial frontal lobesd. Cervical spinal cord
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Question
• A 76 year old with atrial fibrillation presents with reduced speech output, flat affect, and inability to walk. On exam she has minimal verbal output and cannot move either leg. What is the anatomic localization for her symptoms?a. Dominant inferior frontal lobe (Broca’s area)b. Dominant posterior superior temporal lobe
(Wernicke’s area)c. Bilateral medial frontal lobesd. Cervical spinal cord
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Anterior Cerebral Artery
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• Motor– Contralateral leg weakness (distal>proximal)– may be bilateral • single A1• subfalcine herniation
• Sensory
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• Cognitive/affective– Gait apraxia– Akinetic mutism/abulia
• Collosal disconnection syndromes– Left hand ideomotor apraxia, agraphia, tactile
anomia– Left body part agnosia– Alien hand
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Question
• A 67 year old presents with fluent, nonsensical speech with frequent paraphasic errors, neologisms, and right superior quadrant-anopia. Which vascular territory is involved?a. Right MCA inferior divisionb. Left ACAc. Left MCA superior divisiond. Left MCA inferior division
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Question
• A 67 year old presents with fluent, nonsensical speech with frequent paraphasic errors, neologisms, and right superior quadrant-anopia. Which vascular territory is involved?a. Right MCA inferior divisionb. Left ACAc. Left MCA superior divisiond. Left MCA inferior division
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Middle Cerebral Artery
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Superior Division Inferior Division
Motor Contralateral face, arm>leg(Primary, secondary motor cortex)
Sensory Contralateral face, arm>leg(Somatosensory cortex)
Vision Homonymous hemianopia or quadrantanopia(Optic radiations)
Language Expressive aphasia (dominant hemisphere, Broca’s area)
Receptive aphasia (dominant hemisphere, Wernicke’s area)
Prosody Prosodic apraxia (non-dominant hemisphere)
Prosodic agnosia (non-dominant hemisphere)
Other Hemineglect (non-dominant hemisphere)
Constructional apraxia (non-dominant hemisphere)
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• Malignant MCA Stroke– Terminal ICA or M1 occlusion– Massive edema within 2-5 days leading to midline
shift and uncal herniation– Early signs:• Decreased level of consciousness• Ipsilateral pupillary dilation• Ipsilateral hemiparesis
– Decompressive hemicraniectomy increases likelihood of surviving with mRS≤4 if done within 48 hours
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Posterior Circulation Strokes
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Question
• A 73 year old presents with left sided facial numbness, right sided body numbness, ataxia on left finger to nose, and dysphagia. What additional finding is likely on exam?a. Left sided facial droopb. Right arm and leg weaknessc. Left eye ptosis and miosisd. Inability to adduct right eye with left lateral gaze
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Question
• A 73 year old presents with left sided facial numbness, right sided body numbness, ataxia on left finger to nose, and dysphagia. What additional finding is likely on exam?a. Left sided facial droopb. Right arm and leg weaknessc. Left eye ptosis and miosisd. Inability to adduct right eye with left lateral gaze
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Lateral Medullary (Wallenberg) Syndrome
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• Vestibulocerebellar– Vertigo (inferior vestibular nucleus)– Ipsilateral ataxia and hypotonia (inferior
cerebellar peduncle)– Nystagmus, diplopia, ocular torsion
• Crossed sensory loss to pain and temperature – Ipsilateral face (descending spinal nucleus)– Contralateral body (spinothalamic tract)
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• Bulbar muscle weakness– Ipsilateral palate, pharynx, larynx weakness →
dysphonia, dysphagia, hiccups (nucleus ambiguus)
• Autonomic dysfunction– Ipsilateral Horner’s syndrome (descending
sympathetics)
• Respiratory dysfunction– Failure of automatic respiration during sleep
(Ondine’s curse, medullary reticular formation)
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Question
• A 45 year old presents to the hospital with 3 days of neck pain, right hand incoordination after being involved in a motor vehicle accident. Overnight, she complains of a headache and nausea before becoming progressively more somnolent. What treatment is most likely to prevent further neurological worsening?a. Aspirin 325 mgb. Aggressive blood pressure reductionc. Decompressive hemicraniectomyd. Decompressive suboccipital craniectomy
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Question
• A 45 year old presents to the hospital with 3 days of neck pain, right hand incoordination after being involved in a motor vehicle accident. Overnight, she complains of a headache and nausea before becoming progressively more somnolent. What treatment is most likely to prevent further neurological worsening?a. Aspirin 325 mgb. Aggressive blood pressure reductionc. Decompressive hemicraniectomyd. Decompressive suboccipital craniectomy
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PICA Infarct
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• May involve vermis, medial, or lateral inferior cerebellum
• 20% involve dorsolateral medulla• Symptoms– Vertigo, dizziness, nystagmus– Nausea/vomiting, headache– Ipsilateral ataxia, truncal ataxia, truncal
lateropulsion
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• Pseudotumoral cerebellar infarction– Seen in first 2-5 days after full territory PICA
infarction– Headache, vomiting, somnolence → stupor and
coma due to hydrocephalus, downward tonsillar, and upward central herniation
– Early signs: vertical gaze palsy, bilateral Babinski– Requires suboccipital decompressive craniectomy
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Medial Medullary (Dejerine) Syndrome
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• Contralateral hemiparesis (pyramidal tract)• Contralateral loss of light touch, vibration,
proprioception (medial lemniscus)• Ipsilateral tongue weakness (hypoglossal
fibers)
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Question
• A 56 year old with refractory HTN presents with diplopia and left facial droop. On exam he is unable to abduct his left eye and has upper and lower left facial weakness. What is the most likely location of his stroke?a. Left dorsomedial ponsb. Left lateral ponsc. Left ventral ponsd. Right ventral pons
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Question
• A 56 year old with refractory HTN presents with diplopia and left facial droop. On exam he is unable to abduct his left eye and has upper and lower left facial weakness. What is the most likely location of his stroke?a. Left dorsomedial ponsb. Left lateral ponsc. Left ventral ponsd. Right ventral pons
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Basilar Artery Syndromes
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• Pontine Syndromes– Inferior medial pontine syndrome (Foville)– Ventral pontine syndrome (Millard-Gubler,
Raymond)– Lateral pontine syndrome (Marie-Foix)– Locked-in syndrome
• Midbrain Syndromes– Weber syndrome– Benedikt syndrome
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• General rules:– Paramedian base contains descending motor
tracts and crossing cerebellar tracts– Paramedian tegmentum contains oculomotor
pathways– Lateral pons contains sensory and vestibular
nuclei and tracts (relatively spared)
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• Motor– Contralateral hemiparesis– Mild ipsilateral weakness, hyperreflexia, adventitial
movements
• Bulbar– Facial weakness, dyasarthria, dysphagia, dysphonia– Often bilateral– Palatal myoclonus– Pseudobulbar affect
• Severe bilateral corticospinal and corticobulbar involvement results in “locked-in” syndrome
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• Oculomotor– Horizontal gaze palsies (Lateral, INO, one-and-a-
half syndrome)– Skew deviation, ocular bobbing– Pinpoint pupils
• Sensory– Not common, but may involve contralateral loss
of light touch, vibration, and proprioception (medial lemniscus)
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Top of the Basilar
• Embolic occlusion of rostral basilar artery causing ischemia of midbrain, thalami, temporal, and occipital lobes
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• Oculomotor/Pupillary (Parinaud syndrome)– Vertical gaze palsy, setting sun sign– Convergence-retraction nystagmus– Mid position fixed pupils
• Altered mentation– Hypersomnolence, abulia– Peduncular hallucinations– Anterograde or retrograde amnesia
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Question
• A 65 year old presents with vision difficulty and numbness in his left arm and leg. Exam shows a left homonymous hemianopia. Which additional finding might be expected on exam?a. Left hemiparesisb. Difficulty recognizing familiar facesc. Inability to read with preserved writingd. Difficulty with calculations
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Question
• A 65 year old presents with vision difficulty and numbness in his left arm and leg. Exam shows a left homonymous hemianopia. Which additional finding might be expected on exam?a. Left hemiparesisb. Difficulty recognizing familiar facesc. Inability to read with preserved writingd. Difficulty with calculations
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PCA Infarct
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• Vision loss– Contralateral hemianopia– Macular sparing
• Sensory– Contralateral paresthesias, anesthesia– Delayed neuropathic pain (Dejerine-Roussy)
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• Left PCA Stroke– Alexia without agraphia (left occipital lobe +
splenium of corpus collosum)– Gerstmann syndrome (acalculia, agraphia, finger
agnosia, right-left confusion)
• Right PCA Stroke– Prosopagnosia– Visual neglect– Visuospatial disorientation
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• Bilateral PCA strokes– Balint syndrome (optic ataxia, ocular apraxia,
asimultagnosia)– Anton syndrome (denial of cortical blindness,
visual hallucinations)
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Bonus
• Artery of Percheron– Single thalamic
perforator arising from one PCA
– Occlusion results in bilateral thalamic infarcts
– Hypersomnolence, language, and memory disturbance
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Watershed Syndromes
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• Inadequate perfusion of areas at the border between two vascular territories– ACA-MCA, PCA-MCA– Symmetric or asymmetric– Cortical and subcortical regions
• Low cardiac output states: shock, heart failure, arrhythmia
• Large vessel stenosis: atherosclerosis, dissection, vasospasm
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• Bilateral visual loss (optic radiations)• Stupor• Proximal arm and leg weakness sparing the
face hands and feet (man-in-a-barrel)
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LACUNAR SYNDROMES
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• Lipohyalinosis of small, penetrating vessels– Artery of Heubner– Lenticulostriate– Thalamoperforant– Basilar perforators
• Progressive or stuttering course over hours to days
• Lack of cortical signs (aphasia, agnosia, apraxia, anopia, neglect)
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• Pure motor hemiparesis (~50%)– Weakness of face, arm, and leg– Capsular warning syndrome– Internal capsule, corona radiata, pons
• Sensorimotor (15-20%)– Weakness and numbness of face, arm, and leg– Posterolateral thalamus and internal capsule
• Pure sensory (~15%)– Numbness of face, arm, and leg – Thalamus, corona radiata
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• Ataxic hemiparesis (~10%)– Ipsilateral weakness and ataxia– May have dysarthria, nystagmus, gait deviation– Internal capsule or pons
• Clumsy hand-dysarthria (~5%)– Facial weakness, dysarthria, dysphagia, slight
weakness and clumsiness of one hand– Pons
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• Questions?