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CURRICULUM VITAE

STEVEN J. FLIESLER, PhD, FARVO

(revised May, 2019)

CURRENT ACADEMIC TITLE: SUNY Distinguished Professor UB Distinguished Professor Meyer H. Riwchun Endowed Chair Professor of Ophthalmology Vice-Chairman, Department of Ophthalmology Director of Research, Ira G. Ross Eye Institute Vision Research Center University at Buffalo, The State University of New York (S.U.N.Y.) Work Address: Buffalo VA Medical Center VA Western New York Healthcare System (VAWNYHS) 3495 Bailey Avenue- Mail Stop 151 Bldg. 20 (Research Service), Rm 202 Buffalo, NY 14215-1129 PH: 716-862-6538; FAX: 716-862-6526 Email: fliesler@buffalo.edu or steven.fliesler@va.gov Home Address: 204 Ashland Avenue Buffalo, NY 14222-1904 PH: 716-392-1126 (cell) Email: sj_fliesler@yahoo.com Citizenship: U.S.A. Web page: http://medicine.buffalo.edu/faculty/profile.html?ubit=fliesler Wikipedia: https://en.wikipedia.org/wiki/Steven_J._Fliesler EDUCATION: 1. Degrees conferred: Ph.D., Biochemistry (May, 1980), Rice University; Houston, TX B.A., Biochemistry (Dec., 1973), University of California, Berkeley; Berkeley, CA 2. Other professional training:

N.R.S.A. Postdoctoral research fellowship, Retinal biochemistry, Cullen Eye Institute,

Department of Ophthalmology, Baylor College of Medicine, Houston, TX (1979-1982)

Undergraduate studies, Chemistry & Biochemistry, University of California, San Diego; San Diego, CA (1971-1972)

Undergraduate studies (general), College of San Mateo; San Mateo, CA (1969-1971) BOARD CERTIFICATION AND LICENSURE: N/A PROFESSIONAL APPOINTMENTS: A. Current appointments: 2008 – present: Meyer H. Riwchun Endowed Chair Professor of Ophthalmology, and Vice-

Chairman/Director of Research, Department of Ophthalmology (Ross Eye Institute), University at Buffalo (S.U.N.Y.), Buffalo, NY [tenured: 04/2010]

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2008 – present: Professor (secondary appointment), Department of Biochemistry, University at Buffalo (S.U.N.Y.), Buffalo, NY

2008 – present: Member, Neuroscience Graduate Program Faculty, University at Buffalo (S.U.N.Y.), Buffalo, NY

2016 – present Research Career Scientist (GS-15), VAWNYHS, Buffalo, NY 2018 – present SUNY Distinguished Professor, University at Buffalo (S.U.N.Y.) B. Prior appointments: 2014 – 2018 UB Distinguished Professor, University at Buffalo (S.U.N.Y.), Buffalo, NY 2015 – 2016 Research Health Scientist (GS-15), VAWNYHS, Buffalo, NY 2011 – 2015: Research Health Scientist (GS-13), VAWNYHS, Buffalo, NY 2008 – 2010: Health Systems Specialist (GS-12), Veterans Administration Western New

York Healthcare System (VAWNYHS), Buffalo, NY (07/01/09-03/25/10; and 12/30/13 – 06/20/14) Acting Associate Chief of

Staff for Research & Development (ACOS/R&D) 2007 – 2008: Member, Neuroscience Center of Excellence, Saint Louis University

School of Medicine 2001 – 2008: Director of Research, Department of Ophthalmology (Saint Louis

University Eye Institute), Saint Louis University School of Medicine, St. Louis, MO

2000– 2008: Professor (secondary appointment), Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine

1998 - 2008: Member, CORE Graduate Program in Biomedical Sciences, Saint Louis University School of Medicine

1994 – 2008: Professor (primary appointment), Department of Ophthalmology, Saint Louis University Eye Institute, Saint Louis University School of Medicine

1991 – 2008: Member, M.D./Ph.D. Training Program, Saint Louis University School of Medicine

1990 (July) Tenure awarded, Saint Louis University School of Medicine 1988 – 1994: Associate Professor (primary appointment), Department of Ophthalmology,

Saint Louis University School of Medicine 1988 - 1992 Associate Professor (secondary appointment), E.A. Doisy Department of

Biochemistry and Molecular Biology, Saint Louis University School of Medicine

1988 – 2000: Member, Cell and Molecular Biology (CMB) Graduate Training Program, Saint Louis University School of Medicine; Assistant Director (1999) 1988 – 2008: Member, Graduate Faculty, Saint Louis University 1987 - 1988 Assistant Professor, Program in Neuroscience, University of Miami School

of Medicine, Miami, FL 1985 - 1988 Assistant Professor (primary appointment), Department of Ophthalmology /

Bascom Palmer Eye Institute, University of Miami School of Medicine 1985 – 1988: Assistant Professor (secondary appointment), Department of Biochemistry

and Molecular Biology, University of Miami School of Medicine 1983 – 1984: Research Assistant Professor, Department of Ophthalmology, Cullen Eye

Institute, Baylor College of Medicine, Houston, TX 1982- 1983: Research Instructor, Department of Ophthalmology / Cullen Eye Institute,

Baylor College of Medicine (Laboratory of Prof. Joe G. Hollyfield) 1979 - 1982 N.R.S.A. Postdoctoral Research Fellow, Department of Ophthalmology /

Cullen Eye Institute, Baylor College of Medicine (Laboratory of Prof. Robert E. Anderson)

1974 – 1979: Graduate Research Fellow, Department of Biochemistry, Rice University, Houston, TX (Laboratory of Prof. George J. Schroepfer, Jr.)

1973 – 1973: Research Assistant, Department of Biochemistry, University of California, Berkeley, CA (Laboratory of Prof. Bruce N. Ames)

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1972 – 1973: Research Assistant, Geological Research Division, Scripps Institution of Oceanography, La Jolla, CA (Laboratory of Prof. Gustaf Arrhenius)

HONORS, AWARDS, and ELECTED HONORARY SOCIETY MEMBERSHIPS 1971 Bank of America Science and Engineering Scholarship and Academic

Achievement Award, California Junior Colleges State Honor Society College of San Mateo Special Service Award

1972 University Research Foundation Fellowship, Univ. of California, San Diego 1973 University Research Foundation Fellowship, Univ. of California, San Diego 1974-75 Advanced Studies Fellowship, Rice University 1976 Phi Lambda Upsilon (National Chemistry Honor Society, Life Member) 1977-79 Robert A. Welch Foundation Predoctoral Fellowship, Rice University 1979-82 NIH N.R.S.A. Postdoctoral Fellowship (F32 Award)

1987 Visiting Research Professor, Bethesda Eye Institute, Saint Louis University School of Medicine

1992 Marquis Who's Who in Science and Engineering (First Edition) 1992 James S. Adams Scholar, Research to Prevent Blindness, Inc. 1993 - 2008 Sigma Xi- The National Research Honor Society (Saint Louis University

Chapter): Member (1993 – 2008); President-Elect (1994-95 and 2000-01); President (1995-97 and 2001-03); Immediate Past President (1997-98 and 2003-04); Member, Executive Committee (1995–2004); Member, Admissions Committee (1998-2001)

1999 Scientist of the Year, Sigma Xi- Saint Louis University Chapter 2002 2002 Chancellor’s Award in Neuroscience Lecturer, LSU School of Medicine

2007 Senior Scientific Investigator Award, Research to Prevent Blindness 2007, 2010 Nominated for the 2008 Schroepfer Medal (American Oil Chemists’ Soc.) 2008- present Meyer H. Riwchun Endowed Chair Professorship, Department of

Ophthalmology, University at Buffalo/SUNY 2009 Silver Tier Fellow of the Association for Research in Vision and

Ophthalmology (FARVO) 2010 Special Contributions Award, Department of Veteran Affairs, VAWNYHS 2011, 2012 Finalist, Alcon Research Institute Awards 2014 Gold Tier Fellow of the Association for Research in Vision and

Ophthalmology (FARVO) 2014-19 Member (elected), ARVO Board of Trustees (Retinal Cell Biology (RC)

Section Trustee) 2014 (May) SUNY Chancellor’s Award for Excellence in Scholarship and Creative

Activities, University at Buffalo (UB)- State University of New York (SUNY) 2014 (July) UB Distinguished Professor, University at Buffalo- SUNY 2015 ProRetina Conference Keynote Lecturer, Potsdam, Germany 2015 (May) Dowling Society Member, ARVO Foundation 2016-2021 Research Career Scientist Award (RCSA), Dept of Veterans Affairs (GS-15) 2016 Special Recognition Award, International Society for Eye Research (ISER) 2017-20 ARVO President-elect (May 2017-18); President (May 2018-19); Immediate

Past-President (May 2019-20) 2017 Dean’s Award in Ophthalmology and Neuroscience, LSU School of Medicine 2018 (March) SUNY Distinguished Professor, University at Buffalo- SUNY 2018 (Aug.) Roski Eye Institute Distinguished Lecturer, University of Southern California 2018 (Aug.) Jules and Doris Stein Distinguished Lecturer, University of California, Los

Angeles 2019 (March) Distinguished Visiting Lecturer, Gavin Herbert Eye Institute, Dept. of

Ophthalmology, Center for Translational Vision Research, U.C. Irvine. 2019 (April) Distinguished Lecturer, Grand Rounds, Dept. of Ophthalmology, U.C. San

Franciso

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2019 (April) The Nanqiang Memorial Lecture, Department of Ophthalmology & Visual Sciences, Xiamen University, School of Medicine, Xiamen, China.

2019 (May) The Sydney Futterman Memorial Lecture, Department of Ophthalmology, University of Washington, UW Medicine, Seattle, WA.

GOOGLE SCHOLAR web page: https://scholar.google.com/citations?hl=en&pli=1&user=VtQOfIwAAAAJ WEB OF SCIENCE page: http://apps.webofknowledge.com/Search.do?product=WOS&SID=2DvrJ4ZVdMLRWLQjoeP&search_mode=GeneralSearch&prID=7f718120-9089-4bc8-8810-8dc52f074548 PUBLICATIONS:

1. Peer-Reviewed Original Journal Articles (published & in press) http://www.ncbi.nlm.nih.gov/pubmed/?term=Fliesler+SJ

1. Vaughan WJ and Fliesler SJ (1974) Electrophoretic resolution and comparison of brain proteins. J. Neurochem. 23, 279-282. [PMID: 4851825]

2. Fliesler SJ and Schroepfer GJ, Jr (1982) Sterol composition of bovine retinal rod outer segment membranes and whole retina. Biochim. Biophys. Acta 711, 138-148. [PMID: 7066367]

3. Fliesler SJ and Anderson RE (1983) Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res. 22, 79-131. [Invited Review, peer-reviewed] [PMID: 6348799]

4. Fliesler SJ and Schroepfer GJ, Jr (1983) Metabolism of mevalonic acid in cell-free homogenates of bovine retinas: formation of novel isoprenoid acids. J. Biol. Chem. 258, 15062-15070. [PMID: 6654904]

5. Fliesler SJ, Maude MB, and Anderson RE (1983) Lipid composition of photoreceptor membranes from goldfish retina. Biochim. Biophys. Acta- Biomembranes 734(2), 144-152. [No PMID/PMCID available]

6. Fliesler SJ, Tabor GA, and Hollyfield JG (1984) Glycoprotein synthesis in the human retina: localization of the lipid-intermediate pathway. Exp. Eye Res. 39, 153-173. [PMID: 6489469]

7. Fliesler SJ, Rapp LM, and Hollyfield JG (1984) Photoreceptor-specific degeneration caused by tunicamycin. Nature (London) 311, 575-577. [PMID: 6332991]

8. Matheke ML, Fliesler SJ, Basinger SF, and Holtzman E (1984) Effects of monensin on membrane assembly and transport in the frog retinal photoreceptor. I. Light microscopic autoradiography and biochemical analysis. J. Neuroscience 4, 1086-1092. [PMID: 6609224]

9. Ulshafer RJ, Fliesler SJ, and Hollyfield JG (1984) Differential sensitivity of protein synthesis in human retina to a phosphodiesterase inhibitor and cyclic nucleotides. Curr. Eye Res. 3, 383-392. [PMID: 6200271]

10. Fliesler SJ, Kelleher PA, and Anderson RE (1985) Catabolism of myo-inositol to precursors utilized for de novo glycerolipid biosynthesis. J. Neurochem. 44, 171-174. [PMID: 3971119]

11. Hollyfield JG, Fliesler SJ, Rayborn, M.E., Fong SL, Landers RA, and Bridges CD (1985) Rod photoreceptors in the human retina synthesize and secrete interstitial retinol-binding protein. Invest. Ophthalmol. Vis. Sci., 26, 58-67. [PMID: 4048219]

12. Fliesler SJ and Basinger SF (1985) Tunicamycin blocks the incorporation of opsin into retinal rod outer segment membranes. Proc. Natl. Acad. Sci. U.S.A., 82, 1116-1120. [PMCID: PMC397205]

13. Fliesler SJ, Rayborn ME, and Hollyfield JG (1985) Membrane morphogenesis in retinal rod outer segments: inhibition by tunicamycin. J. Cell Biol., 100, 574-587. [PMID: 3155750]

14. Fliesler SJ and Schroepfer GJ, Jr (1986) In vitro metabolism of mevalonic acid in the

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bovine retina. J. Neurochem., 46, 448-460. [PMID: 3941316] 15. Fliesler SJ and Anderson RE (1986) In vivo incorporation of [2-3H]-myo-inositol into frog

opsin. Biochem. Biophys. Res. Commun., 136, 815-821. [PMID: 2939835] 16. Lucas JJ, Makunike C, Basinger SF, and Fliesler SJ (1986) Localization of the lipid

intermediate pathway of protein glycosylation in oviduct cell types. Tissue and Cell, 18, 241-249. [PMID: 3705057]

17. Fliesler SJ, Rayborn ME, and Hollyfield JG (1986) Inhibition of oligosaccharide processing and membrane morphogenesis in retinal rod photoreceptor cells. Proc. Natl. Acad. Sci. U.S.A., 83, 6435-6439. [PMCID: PMC386518]

18. Ulshafer RJ, Allen CB, and Fliesler SJ (1986) Tunicamycin-induced dysgenesis in retinal rod outer segment membranes: I. A scanning electron microscopy study. Invest. Ophthalmol. Vis. Sci., 27, 1587-1594. [PMID: 371139]

19. Defoe DM, Besharse JC, and Fliesler SJ (1986) Tunicamycin-induced dysgenesis in retinal rod outer segment membranes: II. Quantitative freeze-fracture analysis. Invest. Ophthalmol. Vis. Sci., 27, 1595-1601. [PMID: 3771140]

20. Pflugfelder SC, Hernandez E, Fliesler SJ, Alvarez J, Pflugfelder ME, and Forster RK (1987) Intravitreal vancomycin: retinal toxicity, clearance, and interaction with gentamicin. Arch. Ophthalmol., 105, 831-837. [PMID: 3495255]

21. Fliesler SJ and Basinger SF (1987) Monensin stimulates glycerolipid incorporation into outer segment membranes. J. Biol. Chem., 262, 17516-17523. [PMID: 3500951]

22. Keller RK, Fliesler SJ, and Nellis SW (1988) Isoprenoid biosynthesis in the retina: Quantitation of the sterol and dolichol biosynthetic pathways. J. Biol. Chem., 263, 2250-2254. [PMID: 3257490]

23. Rodriguez IR and Fliesler SJ (1988) A 42,000-Da protein in rabbit tissues and in a glycogen synthase preparation cross-reacts with antibodies to glycogenin. Arch. Biochem. Biophys., 260, 628-637. [PMID: 3124759]

24. Anderson DH, William DS, Nietz J, Farris RN, and Fliesler SJ (1988) Tunicamycin-induced degeneration in cone photoreceptors. Visual Neurosci., 1, 153-158. [PMID: 3154792]

25. Cole GJ, Schachner M, and Fliesler SJ (1988) N-linked oligosaccharides are not required for neuron-neuron interactions mediated by neural cell adhesion molecule. Neurosci. Lett., 93, 170-175. [PMID: 3241640]

26. Lingua RW, Parel J-M, Fliesler SJ, FitzGerald PG, Rodriguez IR, and Hernandez E (1988) Preclinical evaluation of photodynamic therapy to inhibit lens epithelial cell proliferation. Lasers and Light in Ophthalmol., 2, 103-113. [No PMID/PMCID available]

27. Olsen KR, Parel J-M, Fliesler SJ, Lee W, and Hernandez E (1989) Biodegradable mechanical retinal fixation: a pilot study. Arch. Ophthalmol., 107, 735-741. [PMID: 2719583]

28. Fliesler SJ, Cole GJ, and Adler AJ (1990) Neural cell adhesion molecule (NCAM) in adult vertebrate retinas: tissue localization and evidence against its role in retina - pigment epithelium adhesion. Exp. Eye Res., 50, 475-482. [PMID: 2373151]

29. Rodriguez IR and Fliesler SJ (1990) Glycogenesis in the amphibian retina: in vitro conversion of [2-3H]mannose to [3H]glucose and subsequent incorporation into glycogen. Exp. Eye Res., 51, 71-78. [PMID: 2373183]

30. Boesze-Battaglia K, Fliesler SJ, and Albert AD (1990) Relationship of cholesterol content to spatial distribution and age of disc membranes in retinal rod outer segments. J. Biol. Chem., 265, 18867-18870. [PMID: 2229047]

31. Keller RK and Fliesler SJ (1990) Incorporation of squalene into rod outer segments. J. Biol. Chem., 265, 13709-13712. [PMID: 2380183]

32. Hall MO, Burgess BL, Arakawa H, and Fliesler SJ (1990) The effect of inhibitors of glycoprotein synthesis and processing on the phagocytosis of rod outer segments by cultured retinal pigment epithelial cells. Glycobiology, 1, 51-61. [PMID: 2136381]

33. Pittler SJ, Fliesler SJ, and Rapp LM (1992) Novel morphological changes in rat retina induced by intravitreal injection of lovastatin. Exp. Eye Res., 54, 149-152. [PMID:

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1541334] 34. Barrong SD, Chaitin MH, Fliesler SJ, Possin DE, Jacobson SG, and Milam AH (1992)

Ultrastructure of connecting cilia in different genetic forms of retinitis pigmentosa. Arch. Ophthalmol., 110, 706-710. [PMID: 1580851]

35. Boesze-Battaglia K, Fliesler SJ, Li J, Young JE, and Yeagle PL (1992) Retinal and retinol promote membrane fusion. Biochim. Biophys. Acta, 1111, 256-262. [PMID: 1420260]

36. Pittler SJ, Fliesler SJ, and Baehr W (1992) Primary structure of frog rhodopsin. FEBS Lett., 313, 103-108. *Featured on journal cover. [PMID: 1426275]

37. Duffin KL, Lange GW, Welply JK, Florman RJ, O'Brien PJ, Dell A, Reason AJ, Morris HR, and Fliesler SJ (1993) Identification and oligosaccharide structure analysis of rhodopsin glycoforms containing galactose and sialic acid. Glycobiology, 3, 365-380 [PMID: 8400551]

38. Fliesler SJ, Florman R, Rapp LM, Pittler SJ, and Keller RK (1993) In vivo biosynthesis of cholesterol in the rat retina. FEBS Letters, 335, 234-238. [PMID: 8253203]

39. Prasad VVTS and Fliesler SJ (1994) Identification of β-Galactosidase activity in purified bovine retinal rod outer segments. Curr. Eye Res., 13, 377-384. [PMID: 8055701]

40. Fliesler SJ, Florman R, and Keller RK (1995) Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. Exp. Eye Res., 60, 57-69. [PMID: 7720806]

41. Pittler SJ, Fliesler SJ, Fisher P, Keller RK, and Rapp LM (1995) In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. J. Cell Biol., 130 (2), 431-439. [PMCID: PMC2199930]

42. Fliesler SJ and Keller RK (1995) Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. Biochem. Biophys. Res. Commun., 210, 695-702. [PMID: 7763243]

43. Fliesler SJ, Boesze-Battaglia K, Paw Z, Keller RK, and Albert AD (1997) Squalene is localized to the plasma membrane in bovine retinal rod outer segments. Exp. Eye Res. 64, 279-282. [PMID: 9176062]

44. Fliesler SJ, Richards MJ, McKay S, and Winkler BS (1997) In vitro metabolic competence of the frog retina: effects of glucose and oxygen deprivation. Exp. Eye Res. 64, 683-692. [PMID: 9245897]

45. Fliesler SJ and Keller RK (1997) Isoprenoid metabolism in the vertebrate retina. Int. J. Biochem. Cell Biol. 29(6), 877-894. [Invited Review, peer-reviewed] [PMID: 9304803]

46. Fliesler SJ, Richards MJ, Miller C-Y, and Peachey NS (1999) Marked alteration of sterol metabolism and composition without compromising retinal development or function. Invest. Ophthalmol. Vis. Sci. 40, 1792-1801. [PMID: 10393050]

47. Keller RK and Fliesler SJ (1999) Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. Biochem. Biophys. Res. Commun. 266(2), 560-563. [PMID: 10600541]

48. Fliesler SJ, Richards MJ, Miller C-Y, and Cenedella RJ (2000) Cholesterol synthesis in the retina: Effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition. Lipids 35, 289-296 [PMID: 10783006]

49. Fliesler SJ, Richards MJ, Miller C-Y, Peachey NS, and Cenedella RJ (2000) Retinal structure and function in an animal model that replicates the biochemical hallmarks of desmosterolosis. Neurochem. Res. 25, 685-694. [PMID: 10905631]

50. Tan E, Wang Q, Quiambao AB, Xu X, Qtaishat NM, Peachey NS, Lem J, Fliesler SJ, Pepperberg DR, Naash MI, and Al-Ubaidi MR (2001) The relationship between opsin over-expression and photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 42, 589-600 [PMID: 11222515]

51. Serfis AB, Brancato S, and Fliesler SJ (2001) Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films. Biochim. Biophys. Acta- Biomembranes 1511, 341-348. [PMID: 11286977]

52. Vaughan DK, Nemke JL, Fliesler SJ, Darrow RM, and Organisciak DT (2002) Evidence for a circadian rhythm of susceptibility to retinal light damage. Photochem. Photobiol.

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75(5), 547-553. [PMID: 12017483] 53. Bicknell IR, Darrow R, Barsalou L, Fliesler SJ, and Organisciak DT (2002) Alterations in

retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats. Mol. Vis. 8, 333-340. (http://www.molvis.org/molvis/v8/a40/) [PMID: 12355060]

54. Elliott MH, Fliesler SJ, and Ghalayini AJ (2003) Cholesterol-dependent Association of Caveolin-1 with Transducin Alpha Subunit in Bovine Photoreceptor Rod Outer Segments:

Disruption by Cyclodextrin and GTPS. Biochemistry 42, 7892-7903. [PMID: 12834341] 55. Kovacs, WJ, Shackelford JE, Tape K, Faust PL, Fliesler SJ, Richards MJ, and Krisans SK

(2004) Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 mouse model. Molec. Cell. Biol. 24, 1-13. [PMID: 14673138]

56. Keller RK, Arnold T, and Fliesler SJ (2004) Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz Syndrome J. Lipid Res. 45, 347-355. [Epub. Nov. 1, 2003] [PMCID: PMC2851617]

57. Fliesler SJ, Peachey NS, Richards MJ, Nagel BA, and Vaughan DK (2004) Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: Electrophysiological, biochemical, and morphological features. Arch. Ophthalmol. 122, 1190-1200. [PMCID: PMC2865831]

58. Nour M, Ding X-Q, Stricker H, Fliesler SJ, and Naash MI (2004) Modulating expression of peripherin/rds in transgenic mice: Critical levels and the effect of over-expression. Invest. Ophthalmol. Vis. Sci. 45, 2514-2521. [PMCID: PMC2937570]

59. Keller RK, Small M, and Fliesler SJ (2004) Enzyme blockade: A nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain. J. Lipid Res. 45, 1952-1957. [Epub 2004 Jul 16.] [PMID: 1528193]

60. Naash MI, Wu T-H, Chakraborty D, Fliesler SJ, Ding X-Q, Nour M, Peachey NS, Lem J., Qtaishat N, Al-Ubaidi MR, and Ripps H (2004) Retinal abnormalities associated with the G90D mutation in opsin. J. Comparative Neurology. 478, 149-163. [PMID: 15349976]

61. Ding X-Q, Nour M, Ritter LM, Goldberg AF, Fliesler SJ, and Naash MI (2004) The R172W Mutation in Peripherin/rds Causes Cone-Rod Dystrophy in Transgenic Mice. Hum. Mol. Genet. 13, 2075-2087. [Epub 2004 Jul 14.] [PMID: 15254014]

62. Stricker H, Ding X-Q, Fliesler SJ, and Naash MI. (2005) The C214S mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Biochem. J. [Jan 19; Epub ahead of print] 388(Pt 2):605-613. [PMCID: PMC1138968]

63. Martin RE, Fliesler SJ, Brush RS, Richards MJ, Hopkins SA, and Anderson RE (2005) Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations. Molec. Vis. 11, 338-346. [PMID: 15928607]

64. Berring EE, Borrenpohl K, Fliesler SJ, and Serfis AB (2005) A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: A fluorescence microscopy study. Chem. Phys. Lipids 136(1), 1-12. [PMID: 15904906]

65. Vaughan DK, Peachey NS, Richards MJ, Buchan B, and Fliesler SJ (2006) Light-induced exacerbation of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Exp. Eye Res. 82, 496-504. [2005 Dec 14; Epub ahead of print] [PMCID: PMC2844790]

66. Richards MJ, Nagel BA, and Fliesler SJ (2006) Lipid hydroperoxide formation in the retina: Correlation with retinal degeneration and light damage in a rat model of Smith-Lemli-Opitz syndrome. Exp. Eye Res. 82, 538-541. [2005 Sep 28; Epub] [PMCID: PMC2844950]

67. Farjo R, Skaggs JS, Nagel BA, Quiambao AB, Nash ZA, Fliesler SJ, and Naash MI (2006) Retention of function without normal disc morphogenesis occurs in cone, but not rod, photoreceptors. J. Cell Biol. 173(1):59-68. *Featured on journal cover. [PMCID: PMC2063789]

68. Correa-Cerro LS, Wassif CA, Kratz L, Miller GF, Munasinghe JP, Grinberg A, Fliesler SJ, and Porter FD. (2006) Development and characterization of a hypomorphic Smith-Lemli-Opitz mouse model and efficacy of simvastatin therapy. Hum. Molec. Genet. 15(6):839-851. [Epub 2006 Jan 30.] [PMID:16446309]

69. Tserentsoodol N, Sztein J, Campos M, Gordiyenko N, Fariss RN, Lee J-W, Fliesler SJ,

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and Rodriguez IR. (2006) Uptake of cholesterol by the retina occurs occurs primarily via an LDL-receptor mediated process. Molec. Vis. 12:1306-1318 [PMID: 17110914] http://www.molvis.org/molvis/v12/a148/

70. Tserentsoodol N, Gordiyenko N, Pasual I, Lee J-W, Fliesler SJ, and Rodriguez IR. (2006) Internal lipid transport in the retina is dependent on HDL-like particles and class B scavenger receptors. Molec. Vis. 12:1319-1333 http://www.molvis.org/molvis/v12/a149/

[PMID: 17110915] 71. Fliesler SJ, Vaughan DK, Jenewein EC, Richards MJ, Nagel BA, Peachey NS. (2007)

Partial rescue of retinal function and sterol steady-state in a rat model of Smith-Lemli-Opitz syndrome. Pediatr. Res. 61(3):273-278. [PMCID: PMC2072818]

72. Chen C-L, Liu I-H, Fliesler SJ, Han X, Huang SS, and Huang JS (2007) Cholesterol attenuates TGF-beta responsiveness: Implications in atherogenesis. J. Cell Sci. 120(Pt 20): 3509-3521. [PMCID: PMC2045688]

73. Farjo R, Fliesler SJ, and Naash MI. (2007) The effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression and outer limiting membrane integrity. J. Comp. Neurol. 504: 619-630. [PMCID: PMC2072815]

74. Conley S, Nour M, Fliesler SJ, and Naash MI. (2007) Late-onset cone photoreceptor degeneration induced by the R172W mutation in Rds and partial rescue by gene supplementation. Invest. Ophthalmol. Vis. Sci. 48(12):5397-5407. [PMCID: PMC2263142]

75. Elliott MH, Nash ZA, Takemori N, Fliesler SJ, McClellan ME, and Naash MI (2008). Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks. J. Neurochem. 104(2):336-352. [Epub ahead of print Oct 18, 2007] [PMCID: PMC2823591]

76. Chakraborty D, Ding X-Q, Fliesler SJ, and Naash MI. (2008) Oligomerization of Rds takes place in the photoreceptor outer segment: Evidence from multiple genetically modified

mouse models and subcellular fractionation. Biochemistry 47:1144-1156. [PMCID:

PMC2788309] 77. Ford DA, Richards MJ, Brush RS, Anderson RE, and Fliesler SJ (2008) Lipidomic

analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: Alterations in docosahexaenoic acid content of phospholipid molecular species. J. Neurochem. 105: 1032-1047. [PMCID: PMC2721972]

78. Nour M, Fliesler SJ, and Naash MI. (2008) Genetic supplementation of rds alleviates a loss-of-function phenotype in the C214S model of retinitis pigmentosa. Adv Exp Med Biol. 613:129-138. [PMCID: PMC2789457]

79. Boesze-Battaglia K, Damek-Poprawa M, Mitchell DC, Greeley L, Brush RS, Anderson RE, Richards MJ, and Fliesler SJ (2008) Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome. J. Lipid Res. 49: 1488-1499. [PMCID: PMC2431111]

80. Chakraborty D, Ding X-Q, Conley SM, Fliesler SJ, Naash MI (2009) Differential requirements for Rds disulfide-linked oligomerization in rods versus cones. Hum. Mol. Genet. 18(5), 797-808. [PMCID: PMC2640204]

81. Kovacs WJ, Tape KN, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK (2009) Peroxisome deficiency causes a complex phenotype due to hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. J. Biol. Chem. 284(11), 7232-7245. [E-pub Dec. 24, 2008] [PMCID: PMC2652311]

82. Rodriguez IR, Fliesler SJ. (2009) Photo-damage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism. Photochem. Photobiol. 85(5):1116-1125 [PMCID: PMC2793098]

83. Cai X, Nash Z, Conley SM, Fliesler SJ, Cooper MJ, Naash MI. (2009) A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles. PLoS One 4(4):e5290. [Epub 2009 Apr 24.] [PMCID: PMC2669177]

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84. Lintker BK, Kpere-Daibo P, Fliesler SJ, Serfis AB. (2009) A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films. Chem. Phys. Lipids 161: 22-31. [PMCID: PMC2748277]

85. Murray AR, Fliesler SJ, Al-Ubaidi MR (2009) Rhodopsin: the functional significance of Asn-linked glycosylation and other post-translational modifications. Ophthal. Genet. 30(3): 109-120. [PMCID: PMC2881540]

86. Ding X-Q, Harry CS, Umino Y, Matveev AV, Fliesler SJ, Barlow RB (2009) Impaired cone function and cone degeneration resulting from CNGB3 deficiency: Down-regulation of CNGA3 biosynthesis as a potential mechanism. Hum Molec Genet 18: 4770-4780. [PMCID: PMC2778372]

87. Cai X, Conley SM, Nash Z, Fliesler SJ, Cooper MJ, Naash MI. (2010) Gene Delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a muse model of retinitis pigmentosa. FASEB J. 24(4): 1178-91. [PMCID: PMC2845431]

88. Sherry DM, Murray AR, Kanan Y, Arbogast KL, Fliesler SJ, Burns ME, Moore KL, Al-Ubaidi MR (2010) Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogensis, retinal function and retinal anatomy. Eur. J. Neurosci. 32(9):1461-1472 [PMCID: PMC3058723]

89. Fliesler SJ, Bretillon L. (2010) The ins and outs of cholesterol in the vertebrate retina. J. Lipid Res. 51(12):3399-3413 (Review; peer-reviewed) [PMCID: PMC2975712]

90. Fliesler SJ (2010) Retinal degeneration in a rat model of Smith-Lemli-Opitz Syndrome: Thinking beyond cholesterol deficiency. Adv Exp Med Biol. 664:481-489. [PMCID: PMC3071641]

91. Chakraborty D, Conley SM, Fliesler SJ, and Naash MI (2010) The function of oligomerization-incompetent RDS in rods. Adv Exp Med Biol. 664:39-46. [PMCID: PMC3161506]

92. Xu J, Morris L, Fliesler SJ, Sherry DM, Ding XQ. (2011) Early onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency. Invest. Ophthalmol. Vis. Sci. 52(6): 3557-3566. [PMCID: PMC3109041]

93. Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RVS. (2011) Deletion of

the p85 regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 52(6): 3775-3783. [PMCID: PMC3109053]

94. Kolesnikov AV, Rikimaru L, Hennig AK, Lukasiewicz PD, Fliesler SJ, Govardovksii VI,

Kefalov VJ, Kisselev OG. (2011) G-protein β-complex is crucial for efficient signal amplification in vision. J. Neurosci. 31(22): 8067-8077. [PMCID: PMC3118088]

95. Carvalho LS, Xu J, Pearson RA, Smith AJ, Bainbridge JW, Morris LM, Fliesler SJ, Ding X-Q, Ali RR. (2011) Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy. Hum Molec Genet 20(16): 3161-3175. [PMCID: PMC3140821]

96. Xu L, Liu W, Sheflin LG, Fliesler SJ, Porter NA (2011) Novel oxysterols observed in tissues and fluids of AY9944-treated rats – a model for Smith-Lemli-Opitz Syndrome. J Lipid Res 52(10): 1810-1820. [PMCID: PMC3173002]

97. Xu J, Morris L, Michalakis S, Biel M, Fliesler SJ, Sherry DM, Ding X-Q (2012) CNGA3 deficiency impairs cone synaptic terminal function and maintenance and leads to secondary rod degeneration and loss of rod terminal integrity. Invest Ophthamol Vis Sci 53(3):1117-1129. [PMCID: PMC3339899]

98. Kovacs WJ, Charles KN, Walter KM, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL (2012) Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in liver of newborn PEX2 knock-out mice. Biochim. Biophys. Acta- Molec Cell Biol Lipids 1821:895-907 [Epub ahead of print Mar 13, 2012] [PMCID: PMC3366256]

99. Xu L, Sheflin LG, Porter NA, Fliesler SJ. (2012) 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz Syndrome.

10

Biochim. Biophys. Acta- Molec Cell Biol Lipids 1821:877-883.[Epub ahead of print Mar 9, 2012] [PMCID: PMC3340457]

100. Li X, McClellan ME, Tanito M, Gartesier P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH (2012) Loss of caveolin-1 impairs retinal function due to a disturbance of the subretinal microenvironment. J. Biol. Chem. 287(20):16424-16434. [PMCID: PMC3351350]

101. Sherry DM, Kanan Y, Hamilton R, Hoffhines A, Arbogast K, Fliesler SJ, Naash MI, Moore K, Al-Ubadi M (2012) Differential developmental deficits in retinal function in the absence of either protein:tyrosine sulfotransferase-1 or -2. PLoS One 7(6):e39702. [PMCID: PMC3382163]

102. Keller RK, Mitchell DA, Goulah CC, Fliesler SJ (2013) Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz syndrome. Lipids 48(3):219-29. [PMCID: PMC3595616]

103. Wu F, Renzhong L, Umino Y, Kaczynski T, Sapkota D, Shengguo L, Xiang M, Fliesler SJ, Sherry DM, Gannon M, Solessio E, Mu X (2013) Onecut1 is essential for horizontal cell genesis and retinal integrity. J. Neurosci. 33(32): 13053-13065. [PMCID: PMC3735885]

104. Tu C, Li J, Jiang X, Sheflin LG, Pfeffer BA, Behringer M, Fliesler SJ*, Qu J* (2013) Ion current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome. Mol. Cell. Proteomics 12(12):3583-3598 *co-corresponding authors. [PMCID: PMC3861709]

105. Fliesler SJ (2013) Antioxidants: The missing key to improved therapeutic intervention in Smith- Lemli-Opitz syndrome? Hereditary Genet 2(2):119. doi:10.4172/2161-1041.1000119 [Review; peer-reviewed] [PMCID: PMC3925008]

106. Gu X, Fliesler SJ, Zhao Y-Y, Stallcup WB, Elliott MH. (2014) Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement and mural cell alteration. Am. J. Pathol. 184(2): 541-555. [PMCID: PMC3906491]

107. Rowan S, Weikel KA, Chang M-L, Nagel BA, Thinschmidt J, Carey AN, Grant MB, Fliesler SJ, Smith DS, Taylor A. (2014) Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. Invest Ophthalmol Vis Sci. 55(1): 492-501. [PMCID: PMC3901416]

108. Conley SM, Stuck MW, Burnett J, Chakraborty D, Azadi S, Fliesler SJ, Naash MI. (2014) Insights into the mechanisms of macular degeneration associated with the R172W mutation in RDS. Am J Hum Genet. 23(12): 3102-3114. [PMCID: PMC4030767]

109. Zhang SX, Sanders E, Fliesler SJ, Wang JJ (2014) Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration. Exp Eye Res. 125: 30-40. [PMCID: PMC4122592]

110. Sapkota D, Chintala H, Wu F, Fliesler SJ, Hu Z, Mu Z. (2014) Onecut 1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc. Natl. Acad. Sci. U.S.A. Sep 30;111(39):E4086-95. [PMCID: PMC4191802]

111. Zhang SX, Ma JH, Bhatta M, Fliesler SJ, Wang JJ. (2015) The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding. Prog Ret Eye Res. 45C: 111-131 [PMCID: PMC4339403]

113. Murray AR, Vuong L, Brobst D, Fliesler SJ, Peachey NS, Gorbatyuk MS, Naash MI, Al-Ubaidi MR. (2015) Glycosylation of rhodopsin is necessary for its stability and incorporation into photoreceptor outer segment discs. Hum. Mol. Genet. 24(10):2709-23. [PMCID: PMC4406288]

114. Pfeffer BA, Xu X, Porter NA, Ramachandra Rao R, Fliesler SJ. (2016) Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density. Exp. Eye Res. 145: 297-316. [PMCID: PMC5024725]

115. Aslebagh R, Pfeffer BA, Fliesler SJ, Darie CC. (2016) Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins. Electrophoresis 37(20): 2615-2623. [PMCID: PMC5215750]

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116. Pfeffer BA, Fliesler SJ (2017) Streamlined duplex live-dead microplate assay for cultured cells. Exp Eye Res 161:17-29 [E-pub ahead of print, May 29, 2017 doi: 10.1016/j.exer.2017.05.011] [PMCID: PMC5697708] See also highlight in:

http://biomedical-advances.org/newtech-20181-4/, in the New Technology section. 117. Fliesler SJ, Peachey NS, Herron J, Hines KM, Weinstock NI, Ramachandra Rao S, Xu

L. (2018) Prevention of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Sci Rep. 8(1):1286. [PMCID: PMC5775248] Erratum: Sci Rep. 8(1):4289 [PMCID: PMC5840346]

118. Gomez NM, Lu W, Lim JC, Kiselyov K, Grishchuk Y, Slaugenhaupt SA, Pfeffer BA, Fliesler SJ, Mitchell CH. (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lipofuscin accumulation. (2018) FASEB J. 32(2):782-94 [online Epub: 10/13/17)] [PMID: 29030399]

119. Allen RS, Motz CT, Feola A, Chesler K, Haider R, Ramachandra Rao S, Skelton LA, Fliesler SJ, Pardue MT. (2018) Long-term functional and structural consequences of

primary blast injury to the eye. J Neurotrauma 35(17): 2104-2116. [PMCID:

PMC6098409]

120. Ramachandra Rao S, Pfeffer BA, Mas Gomez N, Skelton LA, Keiko U, Sparrow JR,

Rowsam AM, Mitchell CH, Fliesler SJ. (2018) Compromised phagosome maturation underlies RPE pathology in whole animal and cell culture models of Smith-Lemli-Opitz

Syndrome. Autophagy 14(10):1796-1817. [PMID: 29979914]

121. Kapphahn RJ, Richards MJ, Ferrington DA, Fliesler SJ. (2018) Lipid-derived and other

oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz

syndrome. Exp Eye Res. 2018 Aug 14. pii: S0014-4835(18)30524-4. doi:

10.1016/j.exer.2018.08.006. [Epub ahead of print] [PMID: 30114413]

122. Fliesler SJ, Xu L. (2018) Oxysterols and retinal degeneration in a rat model of Smith-

Lemli-Opitz syndrome: Implications for an improved therapeutic intervention. Molecules

23(10): 2720. [PMID: 30360379] https://doi.org/10.3390/molecules23102720

2. Peer-Reviewed Journal Articles (submitted/pending): 1.

3. Thesis, Books/Chapters, Special Issues: 1. Fliesler SJ (1979) "Studies on the distribution and metabolism of sterols and other

isoprenoids in the bovine retina (Vol. I & II)." Ph.D. Thesis, Rice University, Houston, Texas (University Microfilms, Ann Arbor, Michigan).

2. Fliesler SJ, Rapp LM, Rayborn ME, Hollyfield JG (1985) Defects in retinal glycoprotein metabolism: putative role in photoreceptor degenerations. In "Retinal Degeneration: Contemporary Experimental and Clinical Studies." (LaVail MM, Hollyfield JG, and Anderson RE, eds.), Alan R. Liss, Inc., New York, pp. 349-371.

3. Hollyfield JG, Rayborn ME, Ulshafer RJ, Fliesler SJ (1985) Simulation of an inherited disease in the normal retina: involvement of cyclic nucleotides. In "Retinal Degeneration: Contemporary Experimental and Clinical Studies." (LaVail MM Hollyfield JG, and Anderson RE, eds.), Alan R. Liss, Inc., New York, pp. 341-348.

4. Hollyfield JG, Fliesler SJ, Rayborn ME, Bridges CD (1985) Rod photoreceptors in the human retina synthesize and secrete interstitial retinol-binding protein. In "The Interphotoreceptor Matrix in Health and Disease." (Bridges CD and Adler A, eds.), Alan R. Liss, Inc., New York, pp. 141-149.

5. Fliesler SJ, Rayborn ME, Hollyfield JG (1986) Protein-bound carbohydrate involvement in plasma membrane assembly: the retinal rod photoreceptor cell as a model. In: "Protein-Carbohydrate Interactions in Biological Systems." (Lark DL, ed.), Academic Press, London, 191-205.

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6. Fliesler SJ, Alvarez J, Hernandez E, Hamasaki D, Navarro O, Warman R (1987) Effects of tunicamycin during early postnatal mammalian ocular development. In "Degenerative Retinal Disorders: Clinical and Laboratory Investigations." (Hollyfield JG, LaVail MM, and Anderson RE, eds.), Alan R. Liss, Inc., New York, pp. 551-569.

7. Fliesler SJ (1988) Retinal rod outer segment membrane assembly: studies with inhibitors of N-linked oligosaccharide biosynthesis and processing. In "Glycoconjugates in Medicine." (Ohyama M, Muramatsu T, and Furuta S, eds.), Professional Postgraduate Services, K.K., Tokyo, pp. 316-323.

8. Milam AH, Fliesler SJ, Chaitin MH, Jacobson SG (1991) Histopathology and immunocytochemistry of human retinal dystrophies. In "Retinal Degenerations." (Anderson RE, Hollyfield JG, and LaVail MM, eds.), CRC Press, Boca Raton, FL, pp. 361-368.

9. Fliesler SJ (1993) In Vitro biosynthetic studies with isolated vertebrate retinas. In: "Photoreceptors" (Hargrave PA, ed.), Vol. 15, Methods in Neurosciences, Academic Press, NY, Chapter 5, pp. 86-107. [Invited Review]

10. Fliesler SJ, Volume Editor (2002) Sterols and Oxysterol: Chemistry, Biology and Pathobiology, “Recent Research Developments in Biochemistry” series, Research Signpost, Kerala, India.

11. Fliesler SJ (2002) “Effects of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” In Sterols and Oxysterols: Chemistry, Biology and Pathobiology (Fliesler SJ, ed.), “Recent Research Developments in Biochemistry” series, Research Signpost, Kerala, India, pp. 77-109.

12. Fliesler SJ, Kisselev OG, Volume Eds. (2007) Signal Transduction in the Retina, CRC Press-Taylor and Francis Group, LLC, Boca Raton, FL.

13. Nour M, Fliesler SJ, Naash MI. (2008) Genetic supplementation of rds alleviates a loss-of-function phenotype in the C214S model of retinitis pigmentosa. In: Recent Advances in Retinal Degeneration Research (Anderson RE, LaVail MM, and Hollyfield JG, eds.), Springer, New York, pp. 129-138.

14. Fliesler SJ (2014) Retinal degeneration and cholesterol deficiency. Chapt. 29, pp. 287-297. In: Handbook of Nutrition, Diet and the Eye (Preedy VR, Ed.), 1st Edn., Elsevier, London.

15. Fliesler SJ, Ferrington DA (2019) Guest Editors: Experimental Eye Research, Special Issue: Role of Lipid and Protein Oxidation in Retinal Degenerations. https://www.sciencedirect.com/journal/experimental-eye-research/special-issue/107T1337ZBV

16. Pittler SJ, Fliesler SJ (2019) Guest Editors: The Molecular and Cellular Basis of Retinal Diseases. Cells (ISSN 2073-4409). https://www.mdpi.com/journal/cells/special_issues/basis_retinal_diseases

4. Published Abstracts: 1. Fliesler, S.J. and Schroepfer, G.J., Jr. (1977) Sterol content of bovine rod outer

segment membranes. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.), 166. 2. Fliesler, S.J. (1980) In vitro metabolism of mevalonic acid by the bovine retina. Fed.

Proc. 39, 1905. 3. Fliesler, S.J., Anderson, R.E. and Lam, D.M.-K. (1980) Isolation of metabolically active

truncated photoreceptors. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.), 178. 4. Fliesler, S.J. (1981) In vitro polyisoprenoid metabolism in the bovine retina. Invest.

Ophthalmol.Vis. Sci. (ARVO Suppl.) 21, 4. 5. Fliesler, S.J., Ulshafer, R.J. and Hollyfield, J.G. (1982) Effects of isobutylmethylxanthine

(IBMX) on protein synthesis in vitro in human retina. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 22, 184.

6. Tabor, G.A., Fliesler, S.J. and Hollyfield, J.G. (1982) Effects of tunicamycin (TM) on glycoprotein synthesis in human retina in vitro. Invest. Ophthalmol. Vis. Sci. (ARVO

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Suppl.) 22, 204. 7. Hollyfield, J.G., Fliesler, S.J. and Ulshafer, R.J. (1982) Simulation of inherited retinal

diseases in the normal retina. Proc. Int. Soc. Eye Res. 8. Fliesler, S.J., Rayborn, M.E. and Hollyfield, J.G. (1983) Effects of tunicamycin on rod

photoreceptor membrane biogenesis. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 24, 279.

9. Matheke, M.L., Fliesler, S.J., Basinger, S.F. and Holtzman, E. (1983) Monensin inhibits the incorporation of opsin into ROS membranes. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 24, 279.

10. Fliesler, S.J., Kelleher, P.A. and Anderson, R.E. (1983) Incorporation of 3H-inositol into retinal rod outer segment membrane phospholipids and protein in vivo. Fed. Proc. 42, 2126.

11. Fliesler, S.J., Rayborn, M.E. and Hollyfield, J.G. (1983) Tunicamycin disrupts the normal assembly of rod outer segment membranes. J. Cell Biol. 97, 413a.

12. Fliesler, S.J., Rapp, L.M. and Hollyfield, J.G. (1984) Intraocular injection of tunicamycin causes a novel photoreceptor-specific retinal degeneration. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 25,17.

13. Hollyfield, J.G., Fliesler, S.J., Rayborn, M.E., Fong, S.-L., Landers, R.A. and Bridges, C.D. (1984) Rod photoreceptors synthesize and secrete interstitial retinol-binding protein in the human retina. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 25, 275.

14. Fliesler, S.J. (1984) Defects in retinal glycoprotein metabolism: putative role in photoreceptor degenerations. Proc. Int. Soc. Eye Res.

15. Hollyfield, J.G., Fliesler, S.J., Rayborn, M.E., Fong, S.-L., Landers, R.A. and Bridges, C.D. (1984) Rod photoreceptors in the human retina synthesize and secrete interstitial retinol-binding protein. Proc. Int. Soc. Eye Res.

16. Fliesler, S.J. and Anderson, R.E. (1985) Catabolism of myo-inositol to precursors of glycerolipid biosynthesis. In "Inositol and Phosphoinositides" (J.E. Bleasdale, J. Eichberg and George Hauser, eds.), Human Press, Clifton, New Jersey, p. 666.

17. Fliesler, S.J., Rayborn, M.E. and Hollyfield, J.G. (1985) Inhibition of opsin oligosaccharide processing blocks normal disc membrane morphogenesis. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 26, 44.

18. Garcia, C.A., Chu, H.H., Matheny, J.L., Chu, L., Zhuang, S., Venger, C. and Fliesler, S.J. (1985) Tunicamycin-induced retinal degeneration in rabbit and primate retinas. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 26, 34.

19. Allen, C.B., Ulshafer, R.J. and Fliesler, S.J. (1985) SEM observations on tunicamycin-induced dysgenesis of rod outer segment discs in Xenopus retina. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 26, 247.

20. Basinger, S.F., Fliesler, S.J., Hoffman, R.T. and Blanchard, V.A. (1985) Monensin stimulates the incorporation of glycerophospholipids into rod outer segment membranes. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 26, 292.

21. Fliesler, S.J., Rayborn, M.E. and Hollyfield, J.G. (1985) Castanospermine effects on opsin glycosylation and rod outer segment disc morphogenesis. J. Cell Biol. (ASCB Abstr.) 100, 186a.

22. Ulshafer, R.J., Allen, C.B. and Fliesler, S.J. (1986) Ultrastructural observations on tunicamycin-induced dysgenesis of rod outer segment discs in Xenopus retinas. Florida Society for Electron Microscopy (Tampa, Florida), February 24-25, 1986.

23. Defoe, D.M., Besharse, J.C. and Fliesler, S.J. (1986) Quantitative freeze-fracture analysis of rod cell membranes in tunicamycin-treated retinas. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 27, 297.

24. Anderson, D.H., Williams, D.S., Neitz, J., Fariss, R.N. and Fliesler, S.J. (1986) Effect of tunicamycin on cone photoreceptors. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 27, 297.

25. Pflugfelder, S.C., Pflugfelder, M.E., Fliesler, S.J., Hernandez, E. and Forster, R.K. (1986) Intravitreal vancomycin: retinal toxicity, clearance, and interaction with

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gentamicin. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 27, 88. 26. Fliesler, S.J. (1986) Evidence for differential requirements of N-linked oligosaccharides

in the mechanisms of outer segment assembly, RPE-photoreceptor adhesion, and phagocytosis. Proc. Int. Soc. Eye Res., 4, 159.

27. Kay, M.J., Kirkman, B.R., Lomako, J., Rodriguez, I.R., Tandecarz, J.S., Fliesler, S.J. and Whelan, W.J. (1987) Enzymatic construction of maltosaccharide chains on a heart protein. Fed. Proc., 46, 1310.

28. Fliesler, S.J. and Hamasaki, D. (1987) Differential sensitivity of retinal neurons to tunicamycin during postnatal ocular development of the cat. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 28, 348.

29. Rodriguez, I.R. and Fliesler, S.J. (1987) [2-3H] Mannose incorporation into glycogen involves conversion to [3H] glucose in the Xenopus retina. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 28, 248.

30. Hall, M.O., Burgess, B.L. and Fliesler, S.J. (1987) The effect of tunicamycin-B2 on the phagocytosis of ROS by cultured rat RPE cells. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 28, 381.

31. Parel, J.M., Lingua, R.W., Fliesler, S.J., FitzGerald, P.G., Rodriguez, I.R. and Hernandez, E. (1987) Preclinical evaluation of photodynamic therapy to retard lens epithelial proliferation after endocapsular lensectomy. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 28, 89.

32. Fliesler, S.J. and Hamasaki, D. (1987) Tunicamycin-induced retinal dysplasia: critical dependence on stage of ocular development. J. Cell Biol. (Abstr.), 105, 319a.

33. Fliesler, S.J., Rodriguez, I.R. and Alvarez, J.A. (1988) Methylasparagine inhibits opsin glycosylation and perturbs disc membrane morphogenesis. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 29, 168.

34. Jacobson, S.G., Fliesler, S.J. and Chaitin, M.H. (1988) X-linked retinitis pigmentosa: retinal function and morphology. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 29, 316.

35. Rodriguez, I.R., Alvarez, J.A. and Fliesler, S.J. (1988) Biochemical and immunocytochemical analysis of glycogenic in vertebrate retinas. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 29, 97.

36. Keller, R.K. and Fliesler, S.J. (1988) Retina isoprenoid biosynthesis: absolute rates of sterol and dolichol pathways. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 29, 386.

37. Cole, G.J., Schachner, M. and Fliesler, S.J. (1988) N-linked oligosaccharides are not required for NCAM function. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 29, 386.

38. Moadel, K., Lingua, R., Dennehy, P., Fliesler, S.J., Hernandez, E. and Feuer, W.J. (1988) Succinylcholine-stimulated muscle tensions in visually deprived and normal domestic cats. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 29, 344.

39. Hall, M.O., Burgess, B.L. and Fliesler, S.J. (1988) The effect of tunicamycin B2 and castanospermine on ROS phagocytosis by cultured RPE cells. Invest. Ophthalmol. Vis Sci. (ARVO Suppl.) 29, 416.

40. Fliesler, S.J. and Rodriguez, I.R. (1988) Studies with amino acid analogs as inhibitors of retinal protein glycosylation and ROS disc membrane assembly. Proc. Int. Soc. Eye Res. 5, 17.

41. Fliesler, S.J., Chaitin, M.H. and Jacobson, S.G. (1988) X-linked retinitis pigmentosa (XLRP): Light and electron microscopic analyses. Proc. Int. Soc. Eye Res. 5, 45.

42. Hall, M.O., Burgess, B.L. and Fliesler, S.J. (1988) Tunicamycin B2, but not castanospermine, inhibits ROS phagocytosis by cultured RPE cells. Proc. Int. Soc. Eye Res. 5, 18.

43 Fliesler, S.J. and Keller, R.K. (1988) Independent incorporation of opsin and isoprenoids into rod outer segment membranes in frog retina. J. Cell Biol. (Abstr.) 107, 768a.

44. Fliesler, S.J., Chaitin, M.H. and Jacobson, S.G. (1989) X-linked retinitis pigmentosa (XLRP): Histopathological and immunocytochemical analyses of a donor eye. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 30, 306.

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45. Keller, R.K. and Fliesler, S.J. (1989) Newly synthesized isoprenoids and opsin are transported via independent pathways to the rod outer segment (ROS). Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 30, 286.

46. Fliesler, S.J. and Keller, R.K. (1989) Differential effects of Brefeldin A on synthesis and transport of lipids and proteins in retinal rod cells. J. Cell Biol. (Abstr.) 109, 206a.

47. Boesze-Battaglia, K., Fliesler, S.J. and Albert, A. (1989) Relationship of lipid composition to age and spatial location of rod outer segment disk membranes. J. Cell Biol. (Abstr.) 109, 241a.

48. Keller, R.K. and Fliesler, S.J. (1990) Brefeldin A blocks transport of proteins, but not lipids, to the rod outer segment. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 31, 470.

49. Fliesler, S.J., Arakawa, H., Cruz, L. and Mann, L. (1990) Effect of 1-deoxymannojirimycin on oligosaccharide processing and ROS membrane assembly. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 31, 5.

50. Fliesler, S.J., Arakawa, H., Mann, L. and Cruz, L. (1990) Effect of inhibitors of N-linked oligosaccharide processing on opsin glycosylation and rod outer segment disc membrane morphogenesis. Glycoconjugate J. 7, 421.

51. Fliesler, S.J., Arakawa, H., O'Brien, P.J., Aguirre, G.D. and Acland, G.M. (1991) Structure of fucosylated oligosaccharides of elkhound rhodopsin. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.), 32, 1150.

52. Keller, R.K. and Fliesler, S.J. (1991) Intracellular transport of phospholipids, squalene and protein to the rod outer segment is differentially affected by temperature and energy inhibitors. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.), 32, 1009.

53. Fliesler, S.J. and Keller, R. K. (1991) Trafficking of lipids and proteins in retinal rod cells: differential effects of vesicular transport inhibitors, temperature and energy poisons. Proc. Fidia Res. Foundn. Symp. on Neurobiol. of Essential Fatty Acids, 53.

54. Fliesler, S.J., Welply, J.K., Duffin, K. L., Florman, R., O'Brien, P. J. and Pittler, S.J. (1992) Oligosaccharide structure and glycosylation site sequences of frog rhodopsin. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 33, 1002.

55. Keller, R.K., Florman, R., Pittler, S.J., Rapp, L. M. and Fliesler, S.J., (1992) De novo synthesis of retina isoprenoid lipids: in vitro vs. in vivo metabolism in rat vs. frog. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 33, 1184.

56. Sharma, S., Kratz-Owens, K., Fliesler, S.J. and Schanzlin, D.J., (1992) Dynamics of keratocyte proliferation and activity following lamellar keratoplasty. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 33, 1000.

57. Barrong, S.D., Chaitin, M.H., Fliesler, S.J., Possin, D.E., Jacobson, S.G. and Milam, A.H. (1992) Ultrastructure of connecting cilia in different genetic forms of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 33, 1066.

58. Duffin, K.L., Welply, J.K., Lange, G.W. and Fliesler, S.J. (1992) Structural characterization of the N-linked oligosaccharides of frog opsin. Proc. 40th Amer. Soc. Mass Spectrometry. Conf. on Mass Spectrometry and Allied Topics, 1597-1598.

59. Fliesler, S.J. (1992) Rhodopsin oligosaccharide structures: the sweeter the better? Proc. Int. Soc. Eye Res. 7, S.3.

60. Keller, R.K., Florman, R. and Fliesler, S.J. (1993) Synthesis, metabolism and transport of squalene in frog retina. Invest. Ophthalmol. Vis. Sci. (ARVO suppl.) 34, 1330.

61. Fliesler, S.J., Florman, R., Richards, M., Dant, J. and Prasad, V.V.T.S. (1994) Metabolic incorporation and turnover of sialic acid in frog rhodopsin. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 35, 2139.

62. Pittler, S.J., Fliesler, S.J., Keller, R.K. and Rapp, L.M. (1994) Requirement of protein prenylation/carboxymethylation in the maintenance of normal retinal structure. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 35, 2151.

63. Florman, R.W., Fliesler, S.J., Albert, A.D., Paw, S., Boesze-Battaglia, K. and Keller, R.K. (1994) Isoprenoid lipid distribution in bovine ros disc membranes and plasma membrane. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 35, 1461.

64. Prasad, V.V.T.S. and Fliesler, S.J. (1994) Presence of β-Galactosidase in bovine rod

16

outer segments. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 35, 1461. 65. Keller, R.K., Vilsaint, F. and Fliesler, S.J. (1994) Quantifying the absolute rate of de

novo cholesterol synthesis in vivo in rat retina using enzyme blockade. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 35, 1460.

66. Fliesler, S.J., Pittler, S.J., Gehrs, K. and Keller, R.K. (1995) Selective inhibitors of protein prenylation and carboxymethylation mimic lovastatin-induced retinal degeneration in rats. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 36, S916.

67. Richards, M., Dant, J. and Fliesler, S.J. (1995) Disruption of ROS disc membrane assembly by rhodopsin glycopeptides, anti-opsin antibodies, and wheat germ agglutinin. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 36, S514.

68. Fliesler, S.J. and Richards, M.J. (1995) In vivo incorporation of [3H]mannosamine into frog rhodopsin. Glycoconjugate J. 12, 510.

69. Fliesler, S.J., Richards, M.J., McKay, S. and Winkler, B.S. (1996) In vitro metabolic compentence of frog retina in the absence of exogenous glucose. Invest. Ophthalmol. Vis. Sci. (ARVO Suppl.) 37, S633.

70. Fliesler, S.J., Richards, M.J., Miller, C.-Y., and Cenedella, R.J. (1996) Effect of U18666A on retinal sterol biosynthesis, histogenesis, and ROS membrane assembly. Mol. Biol. Cell (ASCB Suppl.) 7, 319a.

71. Miller, C.-Y., Richards, M.J., Cenedella, R.J., and Fliesler, S.J. (1997) Effect of U18666A on lipid metabolism, histogenesis, an ROS membrane assembly in neonatal rat retina. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 38, S327.

72. Fliesler, S.J., Miller, C.-Y., and Richards, M.J. (1997) Effect of AY9944 on lipid metabolism, histogensis, and ROS membrane assembly in developing rat retina. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 38, S328.

73. Richards, M.J., Miller, C.-Y., Marietta, R., and Fliesler, S.J. (1997) Mixing of “old” and “new” proteins during ROS disk membrane morphogenesis. Invest. Ophthlamol. Vis. Sci. (ARVO Abstr.) 38, S328

74. Fliesler, S.J., Peachey, N.S., Miller, C-Y., and Richards, M.J. (1998) Alteration of rat retina sterol composition does not affect retinal histogenesis, postnatal development, or electrophysiology. Invest. Ophthalmol. Vis. Sci. 30, S575.

75. Richards, M.J., Naash, M.I., and Fliesler, S.J. (1998) Oligosaccharide structure determination of murine and bovine rhodopsin by Fluorescence-Assissted Carbohydrate Electrophoresis (FACE®). Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 30, S958.

76. Lininger, L.A., Darrow, R.M., Organisciak, D.T., and Fliesler, S.J. (1998) Contribution of rod photoreceptors to total retinal cholesterol in rat. Invest. Ophthalmol. Vis. Sci.

(ARVO Abstr.) 30, S35. 77. Organisciak, D.T., Darrow, R.M., Barsalou, L., Miller, C-Y., and Fliesler, S.J. (1998)

Retinal light damage and the circadian clock. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 30, S989.

78. Fliesler, S.J., Richards, M.J., and Naash, M.I. (1998) Comparative analysis of murine and bovine N-linked oligosaccharide structures by FACE®. Exp. Eye Res. (ICER Suppl.1) 67, S.221.

79. Organisciak, D.T., Darrow, R.M., Barsalou, L., and Fliesler, S.J. (1998) Light damage susceptibility is related to circadian rhythm. Exp. Eye Res. (ICER Suppl.1) 67, S.166.

80. Al-Ubaidi, M.R., Tan, E.M., Li, S., Peachey, N.S., Fliesler, S.J., and Naash, M.I. (1998) Over-expression of opsin leads to retinal degeneration: a study towards the underlying mechanism. Proc. Intl. Symp. Retinal Degeneration (Tubingen, FRG).

81. Fliesler, S.J., Lininger, L.A., Darrow, R.M., and Organisciak, D.T. (1998) Photoreceptor contribution to lipid mass and de novo synthesis in the rat retina. Molec. Biol. Cell (ASCB Abstr.) 9, 354a.

82. Fliesler, S.J., Richards, M.J., and Miller, C.-Y. (1999) Prenylation and actin cytoskeleton dynamics in cultured, transformed Müller and photoreceptor cells. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 40, S155.

83. Richards, M.J., Acland, G. M., Aguirre, G.D., and Fliesler, S.J. (1999) Novel glycan

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structures of canine rhodopsin determined by Fluorophore-Assisted Carbohydrate Electrophoresis (F.A.C.E.). Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 40, S157.

84. Tan, E.M., Wang, Q., Xu, X., Peachey, N.S., Fliesler, S.J., and Al-Ubaidi, M.R. (1999) Over-expression of normal opsin leads to photoreceptor degeneration by overwhelming the translation machinery. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 40, S203.

85. Quiambao, A.B., Fliesler, S.J., Peachey, N.S., Lem, J., and Al-Ubaidi, M.R. (1999) Opsin glycosylation is necessary for normal outer segment morphogenesis and/or maintenance: a transgenic mouse study. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 40, S212.

86. Fliesler, S.J., Richard, M.J., Miller, C.-Y., Peachey, N.S., and Cenedella, R.J. (1999) Cholesterol synthesis in the retina: biochemical, histological, and functional studies. J. Amer. Oil Chem. Soc. (Abstr.), INFORM 10 (5), S56.

87 Fliesler, S.J. (1999) Cholesterol metabolism in relation to retinal histogenesis, structure, and function. Proceedings: “Ophthalmology and Visual Sciences in the 21st Century- An International Symposium”, p. 79.

88. Fliesler, S.J., Richards, M.J., Peachey, N.S., and Kauser, K. (2000) Hypercholesterolemia does not alter retinal sterol composition or compromise retinal structure or function in apolipoprotein E (ApoE)-knockout mice. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 41, S199.

89. Richards, M.J., Fliesler, S.J., McClellan, M., Maude, M.B., and Anderson, R.E. (2000) “Sterol synergism” in the retina: Perturbation of fatty acid composition of retinal membranes as a consequence of altered sterol composition. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 41, S880.

90. Fliesler, S.J. (2000) Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function. Exp. Eye Res. (ICER Suppl.) S.192, 617.

91. Fliesler, S.J., Richards, M.J., Peachey, N.S., Buchan, B., Vaughan, D.K., and Organisciak, D.T. (2001) Potentiation of retinal light damage in an animal model of Smith-Lemli-Opitz syndrome. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 42, S627 (#3373).

92. Richards, M.J., Downs, M.A., Kisselev, O.G., and Fliesler, S.J. (2001) Effects of sterol identity and temperature on rhodopsin bleaching in phospholipid-sterol-rhodopsin liposomes. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 42, S184 (#986).

93. Nemke, J.L., Vaughan, D.K., Fliesler, S.J., Darrow, R., and Organisciak, D.T. (2001) Morphological study of a circadian rhythm of retinal light damage. Invest. Ophthalmol. Vis. Sci. (ARVO Abstr.) 42, S628 (#3374).

94. Fliesler, S.J. and Richards, M.J. (2001) Teaching an old drug new tricks: tunicamycin as a tool for quantifying the mixing of new and old proteins in nascent retinal rod outer segment membranes. Glycobiology 11, 880 (Abstr #53).

95. Keller, R.K., Arnold, T.P., Sutton, J., and Fliesler, S.J. (2002) 7-Dehydrocholesterol and 24-dehydrocholesterol promote the formation of lipid rafts. FASEB J. 16, A910 (Abstr. #678.21).

96. Fliesler, S.J., Richards,M.J., Nagel, B.A., and Peachey, N.S. (2002) Time-dependent effects of AY9944 treatment in rats: Altered electroretinographic responses in an animal model of Smith-Lemli-Opitz syndrome. [Abstract 3955]. 2002 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April 1, 2002.

97. Vaughan, D.V., Richards, M.J., and Fliesler, S.J. (2002) DMTU protects against light-induced retinal degeneration in an animal model of Smith-Lemli-Opitz syndrome. [Abstract 3729]. 2002 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April 1, 2002.

98. Kovacs, W.J., Tape, K., Shackelford, J.E., Keller, G.A., Fliesler, S.J., Faust, P.L., and Krisans, S.K. (2002) Localization of HMG-CoA reductase to brain peroxisomes and analysis of cholesterol biosynthesis in the peroxisome-deficient Pex2 Zellweger mouse. Symposium: Peroxisomal Disorders and Regulation of Genes, Proc. Belgian Soc. Cell

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Devel. Biol. (Sept. 25-28, 2002, Ghent, Belgium) 99. Kovacs, W.J., Tape, K., Shackelford, J.E., Fliesler, S.J., Faust, P.L., and Krisans, S.K.

(2002) Analysis of the peroxisome-deficient Pex2 Zellweger mouse: Alterations in cholesterol homeostasis. Proc. 73rd European Atherosclerosis Society (EAS) Congr. (July 7-10, 2002, Salzberg, Austria)

100. Fliesler, S.J. , Richards, M.J., Nagel, B.A., Vogler, G.A., Peachey, N.S., and Vaughan, D.K. (2003) An improved adult model of Smith-Lemli-Opitz syndrome. [Abstract #3597]. 2003 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April 1, 2003.

101. D.K. Vaughan, Slotten, D.J., Richards, M.J., Nagel, B.A., Peachey, N.S., and Fliesler, S.J. (2003) Effects of fat-soluble vitamins and cholesterol supplementation on retinal structure and function in an animal model of Smith-Lemli-Opitz syndrome. [Abstract #3596]. 2003 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April 1, 2003.

102. Richards, M.J., Nagel, B.A., and Fliesler, S.J. (2003) Lipid Hydroperoxide Formation in an Animal Model of Smith-Lemli-Opitz Syndrome: Correlation with Retinal Degeneration and Exposure to Constant Light. [Abstract # 3548]. 2003 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April 1, 2003.

103. Martin, R.E., Brush, R.S., Fliesler, S.J., Hopkins, S.A., Ranchon, I., and Anderson, R.E. (2003) Characterization of lipid abnormalities in photoreceptor outer segments of P23H and S334ter transgenic rats. [Abstract # 3547]. 2003 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April 1, 2003.

104. Fliesler, S.J., Peachey, N.S., Jeffrey, B.G., Richards, M.J., Nagel, B.A., and Vaughan, D.K. (2004) Dose-response effects of AY9944 on retinal structure, function, and sterol composition in an adult rat model of Smith-Lemli-Opitz syndrome. [Abstract # 2500] 2004 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April, 2004

105. Vaughan, D.K., Jenewein, E., Richards, M.J., Nagel, B.A., Peachey, N.S., and Fliesler, S.J. (2004) Effects of dietary cholesterol supplementation on retinal structure, function, and sterol composition in a rat model of Smith-Lemli-Opitz syndrome. [Abstract # 3585] 2004 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April, 2004.

106. Nour, M., Quiambo, A.B., Nagel, B.A., Fliesler, S.J., and Naash, M.I. (2004) Functional and structural rescue of retinal degeneration in mice carrying loss- and gain-of-function mutations in P/rds by genetic supplementation. [Abstract #3698] 2004 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, April, 2004.

107. Fliesler, S.J. (2004) Defective sterol biosynthesis and retinal degeneration: When bad things happen to nice retinas. Abstracts, 95th AOCS Annual Meeting & Expo [AOCS/JOCS Joint Symposium on Biosciences: Bio 2- Recent Advances in Steroid Research, I], p. 16.

108. Fliesler, S.J. (2004) ): Retinal Degeneration and Defective Sterol Biosynthesis: Potential Role of Oxidative Insult in the Pathobiology Mechanism. Sydney, Australia (Aug. 28-Sept. 3, 2004). Abstracts, XVIth International Congress of Eye Research (ICER).

109. Clarke, D., Small, M., Fliesler, S.J., and Keller, R.K. (2005) Regulation of Cholesterol Synthesis in the Central Nervous System. Abstracts, ASBMB/Experimental Biology 2005 and XXXV Congress of Physiological Sciences, (April 2-6, 2005, San Diego, CA). Poster (Lipid, Lipoprotein, and Cholesterol Metabolism session). FASEB J. (2005) 19: A1387.

110. Kovacs WJ, Shackelford J, Tape K, Richards M, Faust P, Fliesler S, and Krisans S. (2005) The role of peroxisomes for cholesterol homeostasis. [Abstract #787.7],

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ASBMB/Experimental Biology 2005 and XXXV Congress of Physiological Sciences, (April 2-6, 2005, San Diego, CA). Poster (Compartmentation of Lipid Metabolism session) and Platform Presentation (Symposium: Regulation of Metabolic Pathways). FASEB J. (2005) 19: A1387.

111. Fliesler SJ, Richards MJ, Kapphahn BJ, and Ferrington DA. (2005) Opsin resists oxidative damage during retinal degeneration. . [Abstract # 3178] 2005 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, May, 2005.

112. Nagel BA, Richards MJ, and Fliesler SJ (2005). Optic nerve hypomyelination in a rat model of Smith-Leml-Opitz Syndrome. . [Abstract #3166] 2005 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, May, 2005.

113. Richards MJ, Ford DA, and Fliesler SJ (2005) Lipidomic analysis of retinas from control and AY9944-treated rats, a model of Smith-Lemli-Opitz Syndrome. . [Abstract # 3196] 2005 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, May, 2005.

114. Jenewein E.C., Fliesler S.J., Richards M.J., Vaughan D.K. (2005) Effect of AY9944 on the Cone-Dominant Ground Squirrel Retina. [Abstract # 1663] 2005 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, May, 2005.

115. Chakraborty D., Ding X-Q., Quiambao A., Nagel B., Fliesler S.J., Naash M. (2005) Transgenic Analysis of Cys150Ser Mutation in Rds: Distinct Effects on Rod and Cone Photoreceptors. [Abstract #5168] 2005 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, May, 2005.

116. Farjo R., Skaggs J., Nash Z., Quiambao A.B., Moiseyev G., Nagel B.A., Ding X-Q., Ma J-X., Fliesler S.J., Naash M.I. (2005) Cone Photoreceptor Viability in the Absence of Rds Protein. [Abstract #5186] 2005 Annual Meeting Abstract Search and Program Planner [on CD-ROM]. Association for Research in Vision and Ophthalmology, May, 2005.

117. Fliesler, S.J., Richards, M.J., Kapphahn, B.J., and Ferrington, D.A. (2005) Rhodopsin Resists Oxidative Modification During Light- and Metabolically-Induced Retinal Degeneration. [Absract # 1439] Annual Meeting, American Society for Cell Biology (ASCB), San Francisco, CA, Dec. 10-14, 2005.

118. Boesze-Battaglia K, Richards MJ, Brush RS, Anderson RE, Fliesler SJ (2006). Age-Dependent Alterations in Rod Outer Segment Membrane Properties in a Rodent Model of Smith-Lemli-Opitz Syndrome. Abstr.#3739, 2006 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2006.

119. Fliesler SJ, Kapphahn BJ, Ferrington DA, Nagel BA, Richards MJ (2006). Rhodopsin Resists Oxidative Modification by PUFA-Derived Aldehydes and Nitrosylation During Light- and Metabolically-Induced Retinal Degenerations. Abstr.#4565, 2006 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2006.

120. Quiambao AB, Nash Z, Nagel BA, Fliesler SJ, Naash MI (2006). Evaluation of a macular dystrophy genetic mutation in a cone-dominated murine retina. Abstr.#5916, 2006 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2006.

121. Skaggs JS, Farjo R, Quiambao AB, Nagel BA, Fliesler SJ, Naash MI (2006) The major intrinsic protein of the lens (Aquaporin-O) is expressed in the murine retina. Abstr .#5499, 2006 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2006.

122. Kovacs WJ, Tape KN, Shackelford JE, Richards MJ, Fliesler SJ, Faust PL, and Krisans SK. (2006) Disturbed regulation of SREBP/Insig genes in peroxisome-deficient PEX2 Zellweger mice. Abstr.#1244. 46th Annual Meeting, American Society for Cell Biology

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(ASCB), San Diego, CA, Dec. 9-13, 2006. [On CD-ROM] 123. Chakraborty DB, Ding X-Q, Skaggs J, Fliesler SJ, and Naash MI. Oligomerization of

Rds takes place in the photoreceptor outer segment: evidence from multiple mouse models. RD2006, Proceedings of the XIIth International Symposium on Retinal Degeneration, San Carlos de Bariloche, Argentina, October 23 - 28, 2006.

124. Fliesler SJ, Kapphahn BJ, Nagel BA, Richards MJ, and Ferrington DA (2006). Rhodopsin resists oxidative modification during induced retinal degenerations. Abstr. (p.100), Proceedings of the XVII International Congress of Eye Research (ICER), Buenos Aires, Argentina, Oct. 29-Nov.3, 2006.

125. Fliesler SJ, Richards MJ, and Ford DA. (2007) Progressive lipidome changes during retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Abstr .#2496, 2007 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2007.

126. Siddiqui AM, Richards MJ, and Fliesler SJ. (2007) Global differential and temporal transcriptional profiling of retinas from AY9944-treated (SLOS) vs. control rats. Abstr #2498, 2007 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2007.

127. Conley SM, Fliesler SJ, and Naash MI. (2007) Retinal degeneration in mice with I-255/256 deletion mutation in opsin gene: Gene dosage vs. transgene effects. Abstr #4511, 2007 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2007.

128. Cai X, Fliesler SJ, Cooper MJ, Naash MI. (2007) Partial rescue of Rds haploinsufficiency phenotype with DNA nanoparticles. Abstr .#1690, 2007 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2007.

129. Chakraborty D, Fliesler SJ, and Naash MI. (2007) The role of Rds oligomerization in cone outer segment assembly and maintenance. Abstr .#4654, 2007 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2007.

130. Cai X, Fliesler SJ, Cooper MJ, Naash MI (2007) Functional rescue of the Rds haploinsufficency phenotype with non-viral compacted DNA nanoparticles. Abstract, Proceedings, 10th Annual Meeting, American Society for Gene Therapy (ASGT), Seattle, WA, May, 2007.

131. Fliesler SJ. (2007) The molecular and metabolic basis of SLOS: Thinking beyond sterols. Abstract, Proceedings of the Conference on Smith-Lemli-Opitz Syndrome (SLOS) and Inborn Errors of Cholesterol Synthesis, Portland, OR, June 28-30, 2007.

132. Al-Ubaidi MR, Moore KL, and Fliesler SJ. (2007) Investigating the role of protein sulfation in retinal development and maintenance. Proceedings, FASEB Summer Research Conference: “The Biology and Chemistry of Vision”, Snowmass Village, CO, June, 2007.

133. Fliesler SJ. (2007) Global lipidomic and genomic alterations and retinal degeneration in a rat model of Smith-Lemli-Opitz Syndrome.” Abstract, Summer ARVO Conference- Ocular Cell & Molecular Biology, Sarasota, FL, Sept. 6-8, 2007.

134. Mitchell DC, Greeley L, Richards MJ, and Fliesler SJ. (2008) Correlation of photoreceptor membrane biophysical properties with altered sterol and acyl chain composition in a rat model of Smith-Lemli-Opitz syndrome. Abstract, joint meeting, the Biophyscial Society 52nd Annual Meeting and the 16th International Biophysical Congress (IUPAB), Long Beach, CA, Feb. 2007. Biophys. J. (in press)

135. Fliesler SJ, Richards MJ, Nagel BA, Hennig AK, DeBrecht J, and Lukasiewicz PD. Background modifier gene influence on retinal degenerations: The effect of ApoE isoform expression on Rds phenotype characteristics. 2008 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2008 [on CD-ROM, Abstr. #6083].

136. Cai X, Conley SM, Cooper MJ, Fliesler SJ, and Naash MI. Targeting the RPE: A novel

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application for compacted-DNA nanoparticles. 2008 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2008 [on CD-ROM; Abstr. #4782].

137. Conley SM, Sherry DM, Arbogast KL, Nagel BA, Shackelford JR, Fliesler SJ, and Naash.MI. Aquaporin 0 is crucial for proper synapse formation between cones and ON cone bipolar cells. 2008 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2008 [on CD-ROM; Abstr. #5860].

138. Mitchell DC, Greeley L, Richards MJ, and Fliesler SJ. Rod outer segment (ROS) membrane fluidity is decreased relative to controls in an animal model of Smith-Lemli-Opitz syndrome. 2008 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2008 [on CD-ROM; Abstr. #2417].

139. Siddiqui AM, Wassif CA, Porter FD, Richards MJ, and Fliesler SJ. A systems-level approach to temporal transcriptional profiling of retinas in a rat model of Smith-Lemli-Opitz syndrome. 2008 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2008 [on CD-ROM; Abstr. 3067].

140. Naash MI, Cai X, Conley S, Fliesler SJ, Cooper MJ. DNA nanoparticle-mediated gene therapy: Paving the way for Ophthalmological applications in humans. [Invited platform presentation, Sunday Symposium: "Nanomedicine: Applications in Ophthalmology". 2008 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2008 [on CD-ROM; Abstr. #368].

141. Cai X, Fliesler SJ, Cooper MJ, Naash MI. Functional rescue of the rds+/- mouse model with compacted DNA nanoparticles. Proceedings of the XIIIth International Symposium on Retinal Degeneration (RD2008, Emeishan, Chengdu, China, September 18-23, 2008).

142. Conley SM, Fliesler SJ, and Naash MI. Differential requirement of rods vs. cones for rds. Proceedings of the XIIIth International Symposium on Retinal Degeneration (RD2008, Emeishan, Chengdu, China, Sept. 18-23, 2008).

143. Fliesler SJ. Retinal degeneration in the AY9944-Induced rat model of Smith-Lemli-Opitz Syndrome: Biological, biochemical, and biophysical correlates. Altered ROS membrane properties in a rat model of Smith-Lemli-Opitz Syndrome. Proceedings of the XIIIth International Symposium on Retinal Degeneration (RD2008; Emeishan, Chengdu, China, Sept. 18-23, 2008).

144. Al-Ubaidi MR, Sherry DM, Fliesler SJ, and Moore KL. Tyrosyl sulfation of retinal proteins is essential for proper retinal function. Proceedings of the XIIIth International Symposium on Retinal Degeneration (RD2008; Emeishan, Chengdu, China, Sept. 18-23, 2008).

145. Conley SM, Sherry DM, Arbogast KL, Nagel BA, Shackelford JR, Fliesler SJ, and Naash MI. Aquaporin 0 is crucial for proper synapse formation between cones and ON cone bipolar cells. Proceedings, XVIII ICER (International Congress of Eye Research; Beijing, China, Sept. 24-29, 2008).

146. Fliesler SJ. Retinal degeneration and therapeutic intervention in an animal model of a hereditary cholesterol deficiency syndrome (Invited platform presentation). Symposium: Retinal Diseases-Mechanisms and Treatment. Proceedings, XVIII ICER (International Congress of Eye Research; Beijing, China, Sept. 24-29, 2008).

147. Fliesler SJ, Kapphahn RJ, Ferrington DA (2009) Proteome alteration and enhanced oxidative modification of retinal proteins in a rat model of Smith-Lemli-Opitz Syndrome. 2009 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2009 [on CD-ROM, Abstr. #4477].

148. Rodriguez IR, Fliesler SJ (2009) Photo-damage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism. 2009 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2009 [on CD-ROM, Abstr. #5188].

149. Lee JW, Sanchez J, Riddick R, Huang J-D, Fliesler SJ, Rodriguez IR. (2009) Potentiation of visible light-induced photodamage in cultured RPE cells by treatment with

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AY9944, a 7-dehydrocholesterol reductase inhibitor. 2009 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2009 [on CD-ROM, Abstr. #1843].

150. Al-Ubaidi MR, Sherry DM, Fliesler SJ, Moore KL (2009) Protein tyrosine-O-sulfation deficiency leads to impaired retinal function and structure. 2009 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2009 [on CD-ROM, Abstr. #3408].

151. Siddiqui AM, Richards MJ, Fliesler SJ (2009) Effect of Cholesterol Supplementation on the Retinal Gene Transcriptome in a Rat Model of Smith-Lemli-Opitz Syndrome. 2009 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2009 [on CD-ROM, Abstr. #4152].

152. Kisselev OG, Rikimaru LT, Henning AK, Lukasiewicz PD, Fliesler SJ (2009) Visual function in a mouse mutant lacking rod-specific G-protein gamma subunit. 2009 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2009 [on CD-ROM, Abstr. #2993].

153. Fliesler SJ, Kapphahn RJ, Ferrington DA (2009) Retinal proteome alterations in a rat model of Smith-Lemli-Opitz Syndrome, and the effects of a high-cholesterol diet. 2009 ARVO-ISOCB meeting (Ericeira, Portugal, Sept. 9-12, 2009).

154. Sheflin LG, Young JY, Peachey NS, Fliesler SJ (2010) Effects of combined antioxidant/ cholesterol supplementation in a rat model of Smith-Lemli-Opitz syndrome. 2010 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2010 [on CD-ROM, Abstr. #1415].

155. Kanan Y, Sherry DM, Fliesler SJ, Burns ME, Moore KL, Al-Ubaidi MR. (2010) Lack of protein-tyrosine sulfation disrupts retinal function and rod outer segment structure. 2010 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2010 [on CD-ROM, Abstr. #3488].

156. Kolniak TA, Butler MC, Taggart RT, Yay EH, Benz R, Fliesler SJ, Sullivan JM (2010) A novel, fully humanized RHO adRP mouse model. 2010 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2010 [on CD-ROM, Abstr. #4071].

157. Elliott MH, McClellan ME, Mandal MNA, Ash JD, Nagel B, Ryerse J, Fliesler SJ (2010) Caveolin-1 regulates Na+/K+-ATPase activity in the retinal pigment epithelium. 2010 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2010 [on CD-ROM, Abstr. #5970].

158. Fliesler SJ, Sheflin LG, Young JE, Kapphahn RJ, Ferrington DA (2010) Oxidative and proteomic alterations in a rat model of Smith-Lemli-Opitz Syndrome, and the effects of a high-cholesterol diet. 2010 Biennial meeting, International Society for Eye Research (Montreal, Canada; July 18-23, 2010), Abstr. #0348.

159. Fliesler SJ, Sheflin LG, Young JE, Kapphahn RJ, Ferrington DA (2010) Proteomic and oxidative modifications in retina and serum in a rat model of Smith-Lemli-Opitz Syndrome. RD2010, XIVth International Symposium on Retinal Degeneration (Mont-Tremblant, Quebec, Canada; July 13-17, 2010) Poster# 105

160. Xu L, Liu W, Porter NA, Sheflin LG, Young JE, Fliesler SJ (2011) 7-Dehydrocholesterol-Derived Oxysterol Formation and Retinal Degeneration Pathobiology in a Rat Model of Smith-Lemli-Opitz Syndrome. 2011 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2011 [on CD-ROM; Abstr. #2696].

161. Tu C, Jiang X, Qu J, Sheflin LG, Young JE, Pfeffer BA, Fliesler SJ (2011) Retina Proteome Profiling in a Rat Model of Smith-Lemli-Opitz Syndrome Using an Ion-Current-Based Method. 2011 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2011 [on CD-ROM; Abstr. #3332].

162. Sheflin LG, Young JE, Pfeffer BA, Fliesler SJ (2011) Association of the Complement Pathway with Retinal Degeneration in the AY9944-Induced Rat Model of Smith-Lemli-Opitz Syndrome. 2011 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2011 [on CD-ROM; Abstr. #1007].

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163. Xu J-H, Morris L, Fliesler SJ, Sherry DM, Ding X-Q (2011) Progression of Cone Photoreceptor Dysfunction and Degeneration in CNGB3-Deficient Mice. 2011 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2011 [on CD-ROM; Abstr. #1838].

164. Elliott MH, Li X, McClellan ME, Tanito M, Woodruff ML, Fain GL, Garteiser P, Towner RA, Berkowitz BA, Fliesler SJ (2011) Loss of Caveolin-1 Impairs Retinal Function Due to a Disturbance of the Retinal Microenvironment. 2011 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2011 [on CD-ROM; Abstr. #2694].

165. Kolesnikov AV, Rikimaru L, Hennig AK, Lukasiewicz, Fliesler SJ, Govardovski VI,

Kefalov VJ, Kissilev OG. (2011) G-protein -complex is crucial for efficient signal amplification in vision. 2011 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2011 [on CD-ROM; Abstr. #1173].

166. Behringer MD, Pfeffer BA, Fliesler SJ. (2012) Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome is Caspase-Independent, and Involves Cathepsin D Upregulation. 2012 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2012 [on CD-ROM; Abstr. #4286].

167. Pfeffer BA, Patel PH, Xu L, Porter NA, Fliesler SJ. (2012) 7-Dehydrocholesterol-derived Oxysterols are Differentially Cytotoxic to 661W Photoreceptor Cells. 2012 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2012 [on CD-ROM; Abstr. #4300].

168. Mu X, Wu F, Li R, Darshan S, Li S, Xiang M, Fliesler SJ, Gannon M. (2012) Onecut1 is Esssential for the Genesis of Retinal Horizontal Cells. 2012 ARVO Meeting, Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, May, 2012 [on CD-ROM; Abstr. #431].

169. Behringer MD, Pfeffer BA, Fliesler SJ. (2012) Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome is Caspase-Independent, and Involves Cathepsin D Upregulation. RD2012 (Bad Goegging, Regensburg, Bavaria, Germany). July 16-20, 2012.

170. Fliesler SJ. (2012) Oxysterols and Retinal Degeneration. Abstract, Session RC06: Oxidative Stress and Retinal Degeneration. XXth Biennial Meeting of the International Society for Eye Research (ISER); Berlin, Germany. July 21-25, 2012.

171. Fliesler SJ, Goulah CC, Ferrell WD, Marc E, Jones BW. (2013) Retinal Remodeling in a Rat Model of the Smith-Lemli-Opitz Syndrome. Abstract #711, 2013 ARVO Meeting.

172. Pfeffer BA, Xu L, Porter NA, Fliesler SJ. (2013) In vitro Toxicity of 7-Dehydrocholesterol-derived Oxysterols Depends on Retinal Cell Type. 2013 Annual Meeting; Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA, May, 2013 [on CD-ROM; Abstr. #712].

173. Goulah CC, Struys EA, Jansen EEA, Fliesler SJ. (2013) Metabolomic Analysis of a Rat Model of the Smith-Lemli-Opitz Syndrome (SLOS). 2013 Annual Meeting; Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA, May, 2013 [on CD-ROM; Abstract #710.]

174. Gu X, Fliesler SJ, Elliott ME. (2013) Loss of Caveolin-1 Results in Blood-Retinal Barrier Permeability, Venous Enlargement and Mural Cell Alteration. 2013 Annual Meeting; Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA, May, 2013 [on CD-ROM; Abstr. #5610].

175. Rowan S, Weikel K, Chang W-L, Nagel BA, Thinschmidt J, Grant MB, Fliesler SJ, Smith D, Taylor A. (2013) Cfh Genotype Interacts with Dietary Glycemic Index to Modulate Early Age-Related Macular Degeneration-Like Features in mice. 2013 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA, May, 2013 [on CD-ROM; Abstract #6173.]

176. Fliesler SJ, Goulah CC, Pfeffer BA, Ueda K, Sparrow JR. (2014) Elevated ocular A2E and bisretinoid levels in a rat model of Smith-Lemli-Opitz syndrome. 2014 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Orlando, FL;

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May, 2014, Abstract #1707. 177. Pfeffer BA, Wong P, Xu L, Hu Z, Ziesel AC, Ramachandra Rao S, Porter NA, Fliesler

SJ. (2014) Transcriptomic analysis of oxysterol effects on a photoreceptor-derived cell line, with relevance to Smith-Lemli-Opitz syndrome. 2014 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Orlando, FL; May, 2014, Abstract #1708.

178. Xiaowu Gu X, Fliesler SJ; Zhao Y-Y, Stallcup WB, Cohen A, Elliott MH. (2014) A critical role for caveolin-1 in eNOS-dependent retinal arterial autoregulation and eNOS-independent retinal venous pathology. 2014 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Orlando, FL; May, 2014, Abstract #6343.

179. Fliesler SJ, Pfeffer BA, Ueda K, Goulah CC, Sparrow JR. (2014) A2E and other bisretinoids: Potential involvement in RPE pathobiology in a rat model of a human hereditary cholesterol biosynthetic disorder. Abstract, XXI Biennial Meeting, International Society for Eye Research (ISER); San Francisco, CA, July, 2014.

180. Al-Ubaidi M, Murray A, Vuong L, Brobst D, Peachey NS, Fliesler SJ, Naash MI. Glycosylation of rhodopsin: keeper of the gate to the outer segment. Abstract, RD2014 (XVIth International Symposium on Retinal Degeneration), Pacific Grove, CA, July, 2014.

181. Fliesler SJ, Goulah CC, Pfeffer BA, Ueda K, Sparrow JR. (2014) Elevated ocular A2E and bisretinoid levels in a rat model of Smith-Lemli-Opitz syndrome. UB Neuroscience Day Symposium, Buffalo, NY, Sept. 5, 2014.

182. Pfeffer BA, Wong P, Xu L, Hu Z, Ziesel AC, Ramachandra Rao S, Porter NA, Fliesler SJ. (2014) Transcriptomic analysis of oxysterol effects on a photoreceptor-derived cell line, with relevance to Smith-Lemli-Opitz syndrome. UB Neuroscience Day Symposium, Buffalo, NY, Sept. 5, 2014.

183. Fliesler SJ, Goulah CC, Pfeffer BA, Ueda K, Sparrow JR. (2014) Elevated ocular A2E and bisretinoid levels in a rat model of Smith-Lemli-Opitz syndrome. 6th Annual Meeting, SUNY Eye Institute, Syracuse, NY, Sept. 27-28, 2014.

184. Pfeffer BA, Wong P, Xu L, Hu Z, Ziesel AC, Ramachandra Rao S, Porter NA, Fliesler SJ. (2014) Transcriptomic analysis of oxysterol effects on a photoreceptor-derived cell line, with relevance to Smith-Lemli-Opitz syndrome. 6th Annual Meeting, SUNY Eye Institute, Syracuse, NY, Sept. 27-28, 2014.

185. Ramachandra Rao S, Pfeffer BA, Choi M, Francis K, Porter FD, Fliesler SJ. (2015) Understanding the molecular mechanism of RPE pathology in Smith-Lemli-Opitz Syndrome. 2015 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Denver, CO; May, 2015, Abstract #2389.

186. Pfeffer BA, Ramachandra Rao S, Xu L, Porter NA, Fliesler SJ. (2015) Up-regulation of ER and oxidative stress markers induced by oxysterols in a photoreceptor-derived cell line, with relevance to Smith-Lemli-Opitz syndrome. 2015 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Denver, CO; May, 2015, Abstract #2394.

187. Rowan S, Jiang S, Chang M, Cassalman C, McGuire C, Baleja JD, Nagel BA, Fliesler SJ, Taylor A. (2015) Dietary glycemia contributes reversibly to age-related macular degeneration and metabolic disease in aged C57Bl/6J mice. 2015 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Denver, CO; May, 2015, Abstract #2333.

188. Aslebagh R, Fliesler SJ, Pfeffer BA, Darie CC. (2015) Mass spectrometric identification of amino acids modified by 4-hydroxy-2-nonenal (HNE) as a model for proteome-scale analysis of oxidative stress. Abstract, 2015 Annual meeting, American Society for Mass Spectrometry (ASMS), St. Louis, MO; May 31-June 4, 2015. Abstr. #509.

189. Pfeffer BA, Ramachandra Rao S, Xu L, Porter NA, Fliesler SJ. (2015) Up-regulation of ER and oxidative stress markers induced by oxysterols in a photoreceptor-derived cell line, with relevance to Smith-Lemli-Opitz syndrome. 7th Annual Meeting, SUNY Eye Institute, Albany, NY; Sept. 26, 2015.

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190. Rowsam A, Pfeffer BA, Ramachandra Rao S, Fliesler SJ. (2016) Effect of laminin substrate on attachment and morphology of 661W cells in culture. Celebration of Academic Excellence, Undergraduate Research Forum, University at Buffalo (April 7, 2016).

191. Rowsam A, Pfeffer BA, Ramachandra Rao S, Fliesler SJ. (2016) Effect of laminin substrate on attachment and morphology of 661W cells in culture. Annual Research Day, Dept. of Biochemistry, University at Buffalo (May 9, 2016).

192. Fliesler SJ, Pfeffer BA, Ramachandra Rao S, Allen RS, Haider R, Prunty M, Pardue MT. (2016) Effects of blast overpressure on the retina in a rat model of primary blast injury. 2016 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA; May, 2016, Abstract #738.

193. Davis SJ, DeRamus ML, Pfeffer BA, Ramachandra Rao S, Stacks DA, Fliesler SJ, Pittler SJ. (2016) Selective ablation of dehydrodolichyl diphosphate synthase (Dhdds) expression in RPE alters retina structure and function. 2016 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA; May, 2016, Abstract #1752.

194. Ramachandra Rao S, Mas Gomez N, Pfeffer BA, Rowsam A, Mitchell CH, Fliesler SJ. (2016) Compromised phagosome maturation underlies defective RPE clearance in an in vitro model of Smith-Lemli-Opitz Syndrome. 2016 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA; May, 2016, Abstract #6035.

195. Pfeffer BA, Tu C, Li J, Qu J, Fliesler SJ. (2016) Comparative proteomic profiling of cultured RPE cells derived from human embryonic stem cells vs. rhesus monkey. 2016 Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA; May, 2016, Abstract #232.

196. Fliesler SJ, Pfeffer BA, Ramachandra Rao S, Allen RS, Haider R, Prunty M, Pardue MT. (2016) Effects of blast overpressure on the retina in a rat model of primary blast injury. Research Day, VA Western NY Healthcare System; May 18, 2016. *First Prize*

197. Ramachandra Rao S, Mas Gomez N, Pfeffer BA, Rowsam A, Mitchell CH, Fliesler SJ. (2016) Compromised phagosome maturation underlies defective RPE clearance in an in vitro model of Smith-Lemli-Opitz Syndrome. Research Day, VA Western NY Healthcare System; May 18, 2016.

198. Mas Gomez N, Ramachandra Rao S, Pfeffer BA, Rowsam AM, Mitchell CH, Fliesler SJ (2016) Compromised phagosome maturation underlies defective RPE clearance in an in vitro model of Smith-Lemli-Opitz Syndrome. Biennial Meeting, International Society for Eye Research (ISER), Tokyo, Japan; September 22-29, 2016; Abstr. #34.

199. Pittler SJ, Davis SJ, DeRamus ML, Pfeffer BA, Rao SR, Davis DA, Fliesler SJ. (2016) Selective ablation of dehydrodolichyldiphosphate synthase (Dhdds) expression in RPE causes morphologic changes similar to dry AMD. Annual Meeting, American Academy of Optometry; November 9-12, 2016; E-abstract# 165150.

200. Darie CC, Aslebagh R, Pfeffer BA, Fliesler SJ (2016) Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins. [Oral presentation] Eastern Analytical Symposium and Exposition, Somerset, NJ; Nov. 14-16, 2016; Abstr. #317.

201. Fliesler SJ, Ramachandra Rao S, Mas Gomez N, Pfeffer BA, Rowsam AM, Mitchell CH. (2016) Compromised phagosome maturation underlies defective rod outer segment clearance in culture iPCS-derived RPE cells from Smith-Lemli-Opitz Syndrome patients. Annual Meeting, American Society for Cell Biology (ASCB), San Francisco, CA; Dec. 3-8, 2016. Abstr. #P511.

202. Fliesler SJ, Pfeffer BA, Ramachandra Rao S, Allen RS, Motz C, Haider R, Prunty M, Pardue MT. (2017) Effects of blast overpressure on the retina in a rat model of primary blast injury. 6th Military Vision Symposium on Ocular & Vision Injury, Schepens Eye Research Institute of Mass Eye and Ear / Department of Ophthalmology, Harvard

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Medical School, Boston, MA; March 30-31, 2017; Abstr. #05. 203. Fliesler SJ, Peachey NS, Weinstock NI, Herron J, Hines KM, Xu L. (2017) Rescue of

retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. ARVO Annual Meeting; Baltimore, MD; May 7-11, 2017; Abstr. #2491.

204. Fliesler SJ (2017) Selecting the right journal for your publication: Options and considerations.” ARVO Publications Committee Workshop, ARVO Annual Meeting; Baltimore, MD; May 7-11, 2017.

205. Ramachandra Rao S, Butler MC, Stacks DA, Pittler SJ, Sullivan JM, Fliesler SJ. (2017) Rod photoreceptor-specific ablation of dehydrodolichyldiphosphate synthase (DHDDS) causes rapid retinal degenerations: A new model for arRP. ARVO Annual Meeting; Baltimore, MD; May 7-11, 2017; Abstr. #265.

206. Motz CT, Allen RS, Chesler K, Feola A, Haider R, Ramachandra Rao S, Skelton L, Fliesler SJ, Pardue MT. (2017) Long-term functional and structural consequences of primary blast injury to the eye. ARVO Annual Meeting; Baltimore, MD; May 7-11, 2017; Abstr. #1763.

207. Pittler SJ, Davis SA, Ramachandra Rao S, Stacks DA, DeRamus ML, Fliesler SJ. (2017) Selective RPE-ablation of dehydrodolichyl diphosphate synthase (DHDDS) causes morphologic changes similar to geographic atrophy in dry AMD. ARVO Annual Meeting; Baltimore, MD; May 7-11, 2017; Abstr. #5912.

208. Fliesler SJ, Peachey NS, Weinstock NI, Herron J, Hines KM, Xu L. (2017) Retinal degeneration and rescue in a rat model of Smith-Lemli-Opitz syndrome. Smith-Lemli-Opitz Scientific Symposium, Covington, KY; June 22-23, 2017

209. Pfeffer BA, Xu L, Gaile DP, Fliesler SJ. (2017) Genes associated with Smith-Lemli-Opitz Syndrome (SLOS) phenotypes are differentially expressed in 661W cells exposed to 7-dehydrocholesterol-derived oxysterols. Smith-Lemli-Opitz Scientific Symposium, Covington, KY; June 22-23, 2017

210. Patel SB, Ramachandra Rao S, Fliesler SJ (2017) Initial development and characterization of a conditional Dhcr7 knockout mouse model of Smith-Lemli-Opitz Syndrome. Smith-Lemli-Opitz Scientific Symposium, Covington, KY; June 22-23, 2017

211. Ramachandra Rao S, Mas Gomez N, Pfeffer BA, Skelton L, Mitchell CH, Fliesler SJ (2017) Compromised phagosome maturation underlies RPE pathology in whole animal and cell culture models of SLOS. Smith-Lemli-Opitz Scientific Symposium, Covington, KY; June 22-23, 2017

212. Iyengar SK, Halladay CW, Hadi T, Igo RP Jr, Greenberg P, Crawford DC, Sullivan JM, Fliesler SJ, Wu WC, Konicki PE, Peachey NS. (2017) Optimizing accurate classification of electronic health record case control status for age-related macular degeneration in the Million Veteran Project. Annual Meeting, American Society for Human Genetics (ASHG), Orlando, FL, Oct. 17-21, 2017. Progr. #2168T.

213. Kador PF, Salvi R, Fliesler SJ, Pardue MT. (2017) Multifunctional antioxidants are neuroprotective against hearing loss and retinal degeneration. Abstract, SBIR/STTR

Innovation Summit, Tampa, FL, Oct. 3-5, 2017 https://defenseinnovation.us/sbir.html 214. Ramachandra Rao S*, Fliesler SJ. (2017) Rod photoreceptor-specific ablation of

DHDDS causes rapid retinal degeneration. Abstract, 11th Annual Neuroscience Research Day, Buffalo Society for Neuroscience Chapter, Buffalo, NY, Oct. 13, 2017. Abstr. #466. [*Co-winner, First Prize]

215. Fliesler SJ, Au ED, Skelton LA, Ramachandra Rao S, Farkas MH (2018) Comparative RNA-Seq analysis of iPSC-derived human RPE cells from normal and Smith-Lemli-Oitz (SLOS) patients. ARVO Annual Meeting; Honolulu, Hawaii; Apr 29-May 3, 2018; Abstr. #4586.

216. Motz C, Allen RS, Feola A, Daszynski D, Woolman TA, Kador PF, Ramachandra Rao S, Fliesler SJ, Pardue MT (2018) Visual function after acoustic blast overpressure (ABO) injury: Effects of antioxidants and blast frequency. ARVO Annual Meeting; Honolulu, Hawaii; Apr 29-May 3, 2018; Abstr. #5511.

217. Igo RP, Halladay C, Crawford D, Hadi T, Greenberg PB, Sullivan JM, Anger MD,

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Fliesler SJ, Damrauer S, Wu W-C, Konicki PE, Peachey NS, Iyengar SK (2018) Discovery of three novel risk loci for age-related macular degeneration by trans-ethnic genome-wide association analysis in the VA Million Veteran Program. ARVO Annual Meeting; Honolulu, Hawaii; Apr 29-May 3, 2018; Abstr. #4469.

218. Fliesler SJ, Au ED, Skelton LA, Ramachandra Rao S, Farkas MH (2018) Comparative RNA-Seq analysis of iPSC-derived human RPE cells from normal and Smith-Lemli-Oitz (SLOS) patients. Abstract, Annual Research Day, VA Western NY Healthcare System, May 17, 2018.

219. Ross DH, Scian M, Ramachandra Rao S, Atkins WM, Fliesler SJ, Xu L (2018) Rapid monitoring of the kinetics of electrophile detoxification by glutathione S-transferase using ion mobility-mass spectrometry. 66th Conference on Mass Spectrometry and Allied Topics, American Society for Mass Spectrometry (ASMS); San Diego, CA; June 3-7, 2018. Abstr. # 292599.

220. Fliesler SJ, Au ED, Skelton LA, Ramachandra Rao S, Farkas MH (2018) Comparative RNA-Seq analysis of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz (SLOS) patients. Poster: Annual Ophthalmology Symposium, Ross Eye Institute / Dept. of Ophthalmology, Buffalo, NY; June 8, 2018.

221. Iyengar SK, Halladay CW, Hadi T, Anger MD*, Nguyen XM, Igo Jr. RP, Greenberg P, Crawford DC, Sullivan JM, Fliesler SJ, Damrauer SM, Wu WC, Konicki PE, Peachey NS [on behalf of the VA Million Veteran Program] (2018) Multi-algorithm data cube use for case-control classification of age-related macular degeneration in the VA electronic health record and identification of genetic loci associated with AMD. Poster: Annual Ophthalmology Symposium, Ross Eye Institute / Dept. of Ophthalmology, Buffalo, NY; June 8, 2018. [*Oral presentation: M.D. Anger]

222. Fliesler SJ (2018) SLOS, oxysterols, and retinal homeostasis. EVER 2018 Congress, European Association for Vision and Eye Research; Nice, France; October 4-6, 2018. Abstr.# ABS18-0012.

223. Motz C, Allen RS, Feola A, Daszynski D, Woolman TA, Kador PF, Ramachandra Rao S, Fliesler SJ, Pardue MT. (2018) The effect of antioxidant- and vitamin-enriched diets on vision in rats exposed to primary blast injury. 2018 BMES (Biomedical Engineering Society) Annual Meeting, Atlanta, GA; October 17-20, 2018.

224. Pfeffer BA, Xu L, Fliesler SJ. (2018) Treatment of a mouse photoreceptor cell line with 7-dehydrocholesterol-derived oxysterols induces differential expression of autism spectrum disorder-associated genes and allied pathway elements in an in vitro model of Smith-Lemli-Opitz syndrome. Annual Meeting, Society for Neuroscience, San Diego, CA; Nov. 3-7, 2018. Abstr.# 120.02.

225. Fliesler SJ, Pravallika K, Ramachandra Rao S, Pittler SJ. (2019) Lack of overt pathology in a K42E knock-in mouse model of retinitis pigmentosa (RP59) ARVO Annual Meeting; Vancouver, B.C. (Canada); Apr 28-May 2, 2019; Abstr. #450.

226. Skelton LA, Allen RS, Motz CT, Ramachandra Rao S, Pardue MT, Fliesler SJ. (2019) Quantitative analysis of gliosis, microglia distribution, and cytokine expression profiles in rat retina following acoustic blast overpressure exposure. ARVO Annual Meeting; Vancouver, B.C. (Canada); Apr 28-May 2, 2019; Abstr. #4403.

227. Pfeffer BA, Xu L, Fliesler SJ. (2019) Oxysterol-induced expression of genes associated with autism and allied pathways in 661W cells. ARVO Annual Meeting; Vancouver, B.C. (Canada); Apr 28-May 2, 2019; Abstr. #2371.

228. Ramachandra Rao S, Skelton LA, Pfeffer BA, Fliesler SJ. (2019) Considerations in monitoring autophagy in the neural retina: Utility of CAG-RFP-GFP-LC3 transgenic mice. ARVO Annual Meeting; Vancouver, B.C. (Canada); Apr 28-May 2, 2019; Abstr. #1672.

229. Igo RP Jr., Halladay CW, Crawford DC, Hadi T, Greenberg P, Anger MD, Sullivan JM, Fliesler SJ, Wu W-C, Konicki PE, Peachey NS. (2019) Evidence for novel risk loci for age-related macular degeneration on the X chromosome: the VA Million Veteran Program. ARVO Annual Meeting; Vancouver, B.C. (Canada); Apr 28-May 2, 2019; Abstr. #2958.

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230. Farkas MH, Kaczynski TJ, Au ED, Skelton LA, Sousa ME, Fliesler SJ. (2019) High-throughput localization of lncRNAs guides functional studies in the RPE. ARVO Annual Meeting; Vancouver, B.C. (Canada); Apr 28-May 2, 2019; Abstr. #2357.

5. Other Publications (Non-peer-reviewed) 1. Fliesler SJ and Hollyfield JG (1991) In memoriam: Robert J. Ulshafer, Ph.D. (1949-

1990). Invest. Ophthalmol. Vis. Sci. 32, 1436. 2. Fliesler SJ (1994) In memory of Eric Holtzman (1939-1994) Invest. Ophthalmol. Vis.

Sci. 35, 3571. 3. Fliesler SJ (1995) In memoriam: Eric Holtzman (1939-1994) Exp. Eye Res. 60, 1-2. 4. Fliesler SJ (1997) Editorial: Rethinking grant peer review. Science 275, 1399. 5. Fliesler SJ (1997) Editorial Comment: Intravitreal injection of ganglioside GM1 after

ischemia reduces retinal damage in rats. Stroke 28(3), 622. 6. Fliesler SJ (1999) A tribute to Ed Kean, on the occasion of his retirement. Glycobiology

9(1), iii-vii. 7. Fliesler SJ and Bok D (1999) Richard W. Young: And the band marched on. Trends

Cell Biol. 9(7), 280-283. 8. Fliesler SJ (2002) Choosing the Cary 50 Bio UV-Visible Spectrophotometer. Varian

View, Vol. 2, Issue 1 (June, 2002). 9. Fliesler SJ (2010) Editorial: Lipids and lipid metabolism in the eye. J Lipid Res. 51(1), 1-

3. [Epub ahead of print, 27 Oct. 2009] 10. Fliesler SJ (2012) Research Highlight: Take two iron chelators and call me in the

morning. Trans. Vis. Sci. Tech. 1(3):2a http://www.tvstjournal.org/doi/pdf/10.1167/tvst.1.3.2a 11. Fliesler SJ (2013) Editorial: Proceedings of the fourth Annual Meeting of the SUNY

Eye Institute. J Ophthal Vis Res. 8(1), 72-73. http://www.jovr.ir/index.php/jovr/article/viewFile/650/474 12. Fliesler SJ (2013) On the role of membrane structural defects in Smith-Lemli-Opitz

syndrome. J Membra Sci Technol 3: e119. doi:10.4172/2155-9589.1000e119 13. Fliesler SJ (2015) Invited Editorial Commentary-- Cholesterol homeostasis in the retina:

Seeing is believing. J. Lipid Res. 56(1):1-4.

14. Stewart MW, Powers SLD, Fliesler SJ, Parrish RK 2nd. (2018) What’s in a word? Am J

Ophthalmol. 188:xii-xiii [Epub 7 Feb. 2018]

15. Fliesler SJ, Ferrington DA (2019) Editorial: Special Issue on the role of lipid and protein

oxidation in retinal degenerations,” Exp Eye Res. 181, 313-315. https://www.sciencedirect.com/science/article/pii/S0014483519301903

INVITED BIOMEDICAL/SCIENTIFIC PRESENTATIONS: 1. National & International Conferences and Symposia

05/1977 Association for Research in Vision and Ophthalmology (ARVO), "Sterol content of bovine rod outer segment membranes," Sarasota, FL

05/1980 Association for Research in Vision and Ophthalmology (ARVO), "Isolation of metabolically active truncated rod photoreceptors," Orlando, FL

06/1980 American Society of Biological Chemistry (ASBC), "In vitro metabolism of mevalonic acid by the bovine retina," New Orleans, LA

05/1981 Association for Research in Vision and Ophthalmology (ARVO), "In vitro polyisoprenoid metabolism in the bovine retina," Sarasota, FL

05/1982 Association for Research in Vision and Ophthalmology (ARVO), "Effects of isobutylmethylxanthine (IBMX) on protein synthesis in vitro in human retina," Sarasota, FL

05/1982 Association for Research in Vision and Ophthalmology (ARVO), "Effects of

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tunicamycin (TM) on glycoprotein synthesis in human retina in vitro," Sarasota, FL 05/1983 Association for Research in Vision and Ophthalmology (ARVO), "Effects of

tunicamycin on rod photoreceptor membrane biogenesis," Sarasota, FL 06/1983 American Society of Biological Chemistry (ASBC), "Incorporation of 3H-inositol into

retinal rod outer segment membrane phospholipids and protein in vivo," San Francisco, CA

07/1983 Invited participant, Gordon Research Conference on Glycoproteins and Glycolipids, "Membrane morphogenesis in retinal rod photoreceptors: inhibition by tunicamycin," The Holderness School, Plymouth, NH

11/1983 American Society of Cell Biology, "Tunicamycin disrupts the normal assembly of rod outer segment membrane," San Antonio, TX

01/1984 Chilton Conference on Inositol and Phosphoinositides, "Catabolism of myo-inositol to precursors of glycerolipid biosynthesis," Dallas, TX

05/1984 Association for Research in Vision and Ophthalmology (ARVO), "Intraocular injection of tunicamycin causes a novel photoreceptor-specific retinal degeneration," Sarasota, FL

10/1984 VI International Congress of Eye Research, Symposium on Retinal Degenerations, "Defects in retinal glycoprotein metabolism: putative role in photoreceptor degenerations," Alicante, Spain

05/1985 Association for Research in Vision and Ophthalmology (ARVO), "Inhibition of opsin oligosaccharide processing blocks normal disc membrane morphogenesis," Sarasota, FL

06/1985 Federation of European Microbiology Societies (FEMS) and the Swedish Society for Microbiology (SSM), Conference on the Molecular Biology of Microbial Pathogenicity: The Role of Protein-Carbohydrate Interactions, "Protein-bound carbohydrate involvement in plasma membrane assembly: the retinal rod photoreceptor cell as a model," Lulea, Sweden

08/1985 FASEB Summer Research Conferences, The Biology and Chemistry of Vision, "Asparagine-linked oligosaccharide involvement in rod outer segment disc morphogenesis," Saxtons River, VT

11/1985 American Society for Cell Biology (ASCB), "Castanospermine effects on opsin glycosylation and rod outer segment disc morphogenesis," Atlanta, GA

09/1986 Sendai Symposium on Retinal Degeneration, "Effects of tunicamycin on postnatal mammalian ocular development," Sendai, Japan

10/1986 VII International Congress of Eye Research (ICER), "Evidence for differential requirements of N-linked oligosaccharides in the mechanisms of outer segment membrane assembly, RPE-photoreceptor adhesion, and phagocytosis," Nagoya, Japan

02/1987 Scientific Symposium, Twenty-Fifth Anniversary Celebration of the Bascom Palmer Eye Institute,"Experimentally induced photoreceptor degeneration and retinal dysplasia," Miami, FL

02/1987 Seventh Annual Meeting of Florida Biochemists, "Inhibition of oligosaccharide processing and photoreceptor membrane morphogenesis," St. Augustine, FL

02/1987 Invited participant, Gordon Research Conference on Glycoproteins and Glycolipids, "Inhibition of oligosaccharide processing and photoreceptor membrane morphogenesis," Santa Barbara, CA

05/1987 Association for Research in Vision and Ophthalmology (ARVO), "Differential sensitivity of retinal neurons to tunicamycin during postnatal ocular development in the cat," Sarasota, FL

11/1987 American Society for Cell Biology (ASCB), "Tunicamycin-induced retinal dysplasia: Critical dependence on stage of ocular development," St. Louis, MO

05/1988 Association for Research in Vision and Ophthalmology (ARVO), "Methylasparagine inhibits opsin glycosylation and perturbs disc membrane morphogenesis," Sarasota, FL

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09/1988 VIII International Congress of Eye Research (ICER), "Studies with amino acid analogs as inhibitors of retinal protein glycosylation and ROS disc membrane assembly," San Francisco, CA

02/1989 Joint Meeting, American Society for Cell Biology (ASCB) and American Society for Biochemistry and Molecular Biology (ASBMB), "Independent incorporation of opsin and isoprenoids into rod outer segment membranes in frog retina," San Francisco, CA

05/1989 Association for Research in Vision and Ophthalmology (ARVO), "X-linked retinitis pigmentosa (XLRP): Histopathological and immunocytochemical analyses of a donor eye," Sarasota, FL

11/1989 American Society for Cell Biology (ASCB), "Differential effects of Brefeldin A on synthesis and transport of lipids and proteins in retinal rod cells," Houston, TX

05/1990 Association for Research in Vision and Ophthalmology (ARVO), "Effect of 1-deoxymannojirimycin on oligosaccharide processing and ROS membrane assembly," Sarasota, FL

05/1991 Association for Research in Vision and Ophthalmology (ARVO), "Structure of fucosylated oligosaccharides of elkhound rhodopsin." Sarasota, FL

05/1992 Association for Research in Vision and Ophthalmology (ARVO), "Oligosaccharide structure and glycosylation site sequences of frog rhodopsin." Sarasota, FL

09/1992 Xth International Congress of Eye Research (ICER), "Oligosaccharide structures of amphibian rhodopsin: Presence and distribution of sialylated glycoforms." Stresa, Italy

05/1994 Association for Research in Vision and Ophthalmology (ARVO), "Metabolic incorporation and turnover of sialic acid in frog rhodopsin." Sarasota, FL

05/1994 Association for Research in Vision and Ophthalmology (ARVO), Special Interest Group: Photoreceptor Cell Biology: "Protein glycosylation and photoreceptor membrane assembly: What a concept!" Sarasota, FL

11/1994 International Symposium on Retinal Degeneration. "Inhibitors of protein prenylation and carboxymethylation, but not sterol synthesis, cause photoreceptor degeneration in rats." Jerusalem, Israel.

05/1995 Association for Research in Vision and Ophthalmology (ARVO), "Selective inhibitors of protein prenylation and carboxymethylation mimic lovastatin-induced retinal degeneration in rats." Ft. Lauderdale, FL.

08/1995 XIIIth International Symposium on Glycoconjugates: "In vivo incorporation of [3H]mannosamine into frog rhodopsin." Seattle, WA.

12/1996 Annual Meeting, American Society for Cell Biology (ASCB) and the International Congress of Cell Biology: “Effect of U18666A on Retinal Sterol Biosynthesis, Histogenesis, and ROS Membrane Assembly,” San Francisco, CA.

05/1997 Association for Research in Vision and Ophthalmology (ARVO), “Effect ofAY9944 on lipid metabolism, histogensis, and ROS membrane assembly in developing rat retina.” Ft. Lauderdale, FL.

05/1998 Association for Research in Vision and Ophthalmology (ARVO), “Alteration of rat retina sterol composition does not affect retinal histogenesis, postnatal development, or electrophysiology.” Ft. Lauderdale, FL.

07/1998 XIII International Congress of Eye Research (ICER). “Comparative analysis of murine and bovine N-linked oligosaccharide structures by FACE®.” Paris, France.

12/1998 American Society for Cell Biology (ASCB),“Photoreceptor contribution to lipid mass and de novo synthesis in the rat retina.” San Francisco, CA.

05/1999 Association for Research in Vision and Ophthalmology (ARVO), “Prenylation and actin cytoskeleton dynamics in cultured, transformed Müller and photoreceptor cell.” Ft. Lauderdale, FL.

05/1999 American Oil Chemists’ Society (AOCS), 90th Annual Meeting and Expo, “Cholesterol synthesis in the retina: biochemical, histological, and functional studies.” Orlando, FL.

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10/2000 XIV International Congress of Eye Research (ICER), “Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” Santa Fe, NM.

05/2001 Association for Research in Vision and Ophthalmology (ARVO), “Potentiation of retinal light damage in an animal model of Smith-Lemli-Opitz syndrome.” Ft. Lauderdale, FL.

11/2001 GLYCOBIOLOGY 2001, 29th Annual Conference of The Society for Glycobiology, “Teaching an old drug new tricks: tunicamycin as a tool for quantifying the mixing of new and old proteins in nascent retinal rod outer segment membranes.” San Francisco, CA.

05/2002 Association for Research in Vision and Ophthalmology (ARVO), “Time-dependent effects of AY9944 treatment in rats: altered electroretinographic responses in an animal model of Smith-Lemli-Opitz syndrome.” Ft. Lauderdale, FL

10/2002 Xth International Symposium on Retinal Degeneration (RD2002): “A Rodent Model that Mimics the Retinal Abnormalities Associated with the Smith-Lemli-Opitz Syndrome.” Bürgenstock, Switzerland

08/2004 XVIth International Congress of Eye Research (ICER): “Retinal Degeneration and Defective Sterol Biosynthesis: Potential Role of Oxidative Insult in the Pathobiology Mechanism.” Sydney, Australia (Aug. 28-Sept. 3, 2004)

09/2008 XVIIIth International Congress of Eye Research (ICER), Symposium: Retinal Diseases- Mechanisms and Treatment. “Retinal Degeneration and Therapeutic Intervention in a Animal Model of a Hereditary Cholesterol Deficiency Syndrome." Beijing, China (Sept. 23-30, 2008)

07/2010 XVIV Biennial Meeting, International Society for Eye Research (ISER), Symposium: Retinal Crystallins in Health and Disease- “Oxidative and Proteomic Alterations in a Rat Model of Smith-Lemli-Opitz Syndrome and the Effects of a High-Cholesterol Diet.” Montreal, Quebec, Canada (July 18-23, 2010)

07/2012 XXth Biennial Meeting, International Society for Eye Research (ISER), Symposium, Session RC06: Oxidative Stress and Retinal Degeneration- “Oxysterols and Retinal Degeneration.” Berlin, Germany (July 21-25, 2012).

01/27/17 “How to Support Faculty with Resources Other Than Money.” Breakfast with Colleagues Networking Roundtables, RT10, 2017 AUPO (Association of University Professors of Ophthalmology) Annual Meeting, San Diego, CA; January 25-28, 2017.

05/09/17 “Rescue of Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome. ARVO Annual Meeting, Baltimore, MD; May 7-11, 2017.

05/07/17 “Selecting the Right Journal for Your Publication: Options and Considerations.” ARVO Publications Committee Workshop, ARVO Annual Meeting, Baltimore, MD; May 7-11, 2017.

06/22/17 “Retinal Degeneration and Rescue in a Rat Model of Smith-Lemli-Opitz Syndrome. Smith-Lemli-Opitz Scientific Symposium, Covington, KY; June 23-24, 2017

01/25/19 “How to Deal with Problem Faculty.” Breakfast Roundtable Discussion, Annual Meeting, Association of University Professors of Ophthalmology (AUPO), Ft. Lauderdale, FL, January 24-26, 2019.

01/26/19 “Tips for Evaluating the Research of Residency Applicants.” Symposium on Residency Matching Process, Annual Meeting, Association of University Professors of Ophthalmology (AUPO), Ft. Lauderdale, FL, January 24-26, 2019.

04/12/19 “Publishing Ethics.” Workshop on scientific publishing. Chinese Congress of Research in Vision and Ophthalmology (CCRVO); Xiamen, China. April 11-13, 2019.

04/29/19 “Authorship Ethics: Plagiarism-- Walking on the Dark Side.” ARVO Publishing Workshop: “Publishing-- The Light and the Dark Side.” 2019 ARVO Annual Meeting, Vancouver, B.C.; April 29, 2019.

05/02/19 “Cholesterol Biosynthesis Disorders.” Special Interest Group (SIG)— “Lipids and eye diseases: Where should we focus?” 2019 ARVO Annual Meeting, Vancouver, B.C.; May 2, 2019.

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2. Invited Lectures / Seminars

08/1983 "Protein Glycosylation and Photoreceptor Membrane Assembly." Berman-Gund Lab. for the Study of Retinal Degenerations, Harvard Medical School, Boston, MA

05/1984 "Protein Glycosylation and Photoreceptor Membrane Assembly." Dept. of Neurosciences, University of Florida, Gainesville, FL

09/1984 "Glycoprotein Metabolism and Photoreceptor Degeneration." Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL

09/1984 "Dolichol-Dependent Protein Glycosylation and Photoreceptor Membrane Biogenesis." Dept. of Biochemistry, University of Miami School of Medicine, Miami, FL

09/1984 "Dolichol-Dependent Protein Glycosylation and Photoreceptor Membrane Biogenesis." Dept. of Biochemistry, University of South Florida, College of Medicine, Tampa, FL

10/1984 "Defects in Retinal Glycoprotein Metabolism: Putative Role in Photoreceptor Degenerations." VI International Congress Eye Research, Alicante, Spain

05/1985 "Isolation and Biochemical Analysis of Membrane Lipids." Graduate Biochemistry Course, University of South Florida College of Medicine, Tampa, FL

06/1985 "Protein-Bound Carbohydrate Involvement in Plasma Membrane Assembly: The Retinal Rod Photoreceptor Cell as a Model." Conference on the Molecular Biology of Pathogenic Microorganisms: The Role of Protein-Carbohydrate Interactions, Federation of European Microbiology Societies and the Swedish Society for Microbiology, Lulea, Sweden

11/1985 "Opsin Oligosaccharides and Photoreceptor Membrane Morphogenesis." ASBC special interest group meeting on cell biology of the retina, Atlanta, GA

07/1986 "Photoreceptor Membrane Morphogenesis: The Role of Oligosaccharides." Woods Hole Marine Biological Laboratories, Woods Hole, MA

07/1986 "A Putative Role for Membrane-Bound Oligosaccharides in Vertebrate Retinal Photoreceptor Membrane Morphogenesis." Retina Foundation, Eye Research Institute, Boston, MA

09/1986 "Effects of Tunicamycin During Postnatal Mammalian Ocular Development." Sendai Symposium on Retinal Degenerations, Sendai, Japan

09/1986 "Evidence for Differential Requirements of N-Linked Oligosaccharides in the Mechanisms of Outer Segment Membrane Assembly, RPE-Photoreceptor Adhesion, and Phagocytosis." VII International Congress of Eye Research, Nagoya, Japan

01/1987 "Photoreceptor Membrane Morphogenesis: New Insights into an Old Problem." Jules Stein Eye Institute, UCLA, Los Angeles, CA

02/1987 "Photoreceptor Membrane Morphogenesis: New Insights into an Old Problem." Division of Biological Sciences, UCSB, Santa Barbara, CA

07/1987 "Photoreceptor Membrane Assembly: The Role of Protein Glycosylation." Bethesda Eye Institute, St. Louis University School of Medicine, St. Louis, MO

09/1987 "Retinal Rod Outer Segment Membrane Assembly: Studies with Inhibitors of Enzymes Involved in N-Linked Oligosaccharide Biosynthesis and Processing." Kagoshima International Symposium: Glycoconjugates in Medicine, Kagoshima, Japan

04/1988 "Role of N-Linked Oligosaccharides in Photoreceptor Disc Morphogenesis." Eye Research Institute, Oakland University, Detroit, MI

06/1988 "Retinal Degeneration and Dysplasia: Novel Experimental Animal Models." Dept. of Ophthalmology, Washington University School of Medicine, St. Louis, MO

10/1988 "Photoreceptor Membrane Assembly: Studies with Inhibitors of Protein Glycosylation and Processing." Dept. of Pharmacology, St. Louis University School of Medicine, St. Louis, MO

04/1989 "Membrane Assembly and Protein Glycosylation in Retinal Photoreceptor Cells: Now and Zen." Dept. of Biochemistry, Kansas State University, Manhattan, KS

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05/1989 "Protein Glycosylation and Photoreceptor Membrane Assembly: Now and Zen." Dept. of Biochemistry, State University of New York at Buffalo, Buffalo, NY

09/1989 "Protein Glycosylation and Retinal Rod Outer Segment (ROS) Membrane Assembly: Studies with Amino Acid Analogs as Inhibitors of Oligosaccharyl Transferase." Xth International Symposium on Glycoconjugates, Jerusalem, Israel

10/1989 "Protein Glycosylation and Photoreceptor Membrane Assembly." National Eye Institute, National Institutes of Health (NEI/NIH), Bethesda, MD

11/1989 "Differential Effects of Brefeldin A on Synthesis and Transport of Lipids and Proteins in Rod Photoreceptors." Symposium on The Cell Biology of Vision, Cullen Eye Institute, Baylor College of Medicine, Houston, TX

10/1990 "Effect of Inhibitors of N-linked Oligosaccharide Processing on Opsin Glycosylation and Rod Outer Segment Disc Membrane Morphogenesis." Society for Complex Carbohydrates, 19th Annual Meeting, San Diego, CA

03/1991 "The Role of Protein Glycosylation in Photoreceptor Membrane Assembly". Dept. of Anatomy and Cell Biology, Medical University of South Carolina, Charleston, SC

07/1991 "Protein Glycosylation and Retinal Rod Outer Segment Membrane Morphogenesis." Department of Pathology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX

10/1991 "Membrane Assembly in Retinal Rod Cells: Studies with Inhibitors of Glycoprotein Oligosaccharide Synthesis and Processing." Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS

12/1993 "Zen and the Art of Photoreceptor Membrane Assembly." Department of Anatomy and Neurobiology, St. Louis University School of Medicine, St. Louis, MO

02/1994 "Zen and the Art of Photoreceptor Membrane Assembly." Department of Biochemistry and Molecular Biology, Distinguished Scientists Seminar Program, University of South Alabama College of Medicine, Mobile, AL

03/1994 "Zen and the Art of Photoreceptor Membrane Assembly." Department of Biology, St. Louis University School of Medicine, St. Louis, MO

03/1994 "Zen and the Art of Photoreceptor Membrane Assembly." Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO

05/1994 "Protein Glycosylation and Photoreceptor Membrane Assembly: What a Concept!" Special Symposium: "Disc Morphogenesis in Photoreceptors; The Final Steps.", ARVO, Sarasota, FL

12/1994 "Membranes, Molecules, and Metabolism in Retinal Photoreceptor Cells." Department of Anatomy and Cell Biology, University of North Texas, Health Science Center at Ft. Worth, Ft. Worth, TX

03/1995 "Cruising With Isoprenoids: They're Not Just for Lipid Biosynthesis, Anymore!" Department of Biochemistry and Molecular Biology, University of South Florida, Tampa, FL

04/1995 "Cruising With Isoprenoids: They're Not Just for Lipid Biosynthesis, Anymore!" Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO

07/1995 "Differential Effects on Inhibitors of Isoprenoid Metabolism on Retinal Structure and Function." Oklahoma Center for Neuroscience, University of Oklahoma, Oklahoma City, OK

08/1995 "Differential Effects on Inhibitors of Isoprenoid Metabolism on Retinal Structure and Function." Department of Ophthalmology, University of Seattle, Seattle, WA

10/1995 "Protein Prenylation and Cytoarchitecture: Lessons from the Retina", Ohio State University, Biotechnology Center, Columbus, OH

03/1996 "Protein Glycosylation and Membrane Morphogenesis in Retinal Rod Cells", University of Illinois, Chicago, Department of Ophthalmology and Vision Science, Chicago, IL

04/1996 "Isoprenoid Metabolism in Vertebrate Retinas - Now and Zen", Symposium: The Biochemistry of Sterols, 87th AOCS Annual Meeting and Expo, Indiana Convention

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Center and RCA Dome, Indianapolis, IN 06/1996 "Protein Glycosylation and Membrane Morphogenesis in Retinal Rod Cells",

Cleveland Clinic Foundation, Cleveland, OH 10/1996 “Molecular Trafficking and Membrane Assembly in Retinal Rod Photoreceptor Cells”,

Wright State University, Dept. of Biochemistry & Molecular Biology, Dayton, OH 03/1997 “Molecular Trafficking and Membrane Assembly in Retinal Rod Cells”, Dept. of

Biochemistry and Molecular Biology, University of South Florida, College of Medicine, Tampa, FL

10/1997 “Isoprenoid Metabolism in the Vertebrate Retina: Experimental Studies and Clinical Relevance”, Arkansas Center for Eye Research 10th Anniversary Celebration- “Searching with Unlimited Vision”, Jones Eye Institute, University of Arkansas Medical School, Little Rock, AR

10/1997 “Isoprenoid Metabolism in the Vertebrate Retina: Experimental Studies and Clinical Relevance”, 25th Anniversary Symposium, Department of Biochemistry and Cell Biology, Rice University, Houston, TX

03/1998 “Protein Prenylation, Isoprenoid Metabolism, and Retinal Structure and Function,” National Eye Institute, National Institutes of Health, Bethesda, MD

04/1998 “Protein Prenylation, Isoprenoid Metabolism, and Retinal Structure and Function,” Department of Ophthalmology, The Cleveland Clinic Foundation,

Cleveland, OH 10/1998 “Cholesterol in the retina: A slippery tale.” Vision Science Seminar Series, Dept. of

Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, MO

03/1999 "A funny thing happened on my way down the cholesterol pathway." Department of Biology, California State University, Dominguez Hills, Carson CA

04/1999 "A funny thing happened on my way down the cholesterol pathway." Annual Scientific Lecture, Sigma Xi, Saint Louis University Chapter, St. Louis, MO

04/1999 "Isoprenoid Metabolism in the Vertebrate Retina: Experimental Studies and Clinical Relevance." Dept. of Pathology, Saint Louis University School of Medicine

05/1999 American Oil Chemists’ Society (AOCS), 90th Annual Meeting and Expo, “Cholesterol synthesis in the retina: biochemical, histological, and functional studies.” Orlando, FL.

08/1999 "Isoprenoid Metabolism in the Vertebrate Retina: Experimental Studies and Clinical Relevance." Dept. of Cell Biology, The Scripps Research Institute, La Jolla, CA.

09/1999 “Cholesterol Metabolism in Relation to Retinal Histogenesis, Structure, and Function.” Symposium: Ophthalmology and Visual Sciences in the 21st Century. Cole Eye Institute, the Cleveland Clinic Foundation, Cleveland, OH.

09/1999 “Cholesterol Metabolism in Relation to Retinal Histogenesis, Structure, and Function.” Neurosciences Colloquium, The St. John’s Mercy Medical Center, St. Louis, MO.

01/2000 "Isoprenoid Metabolism in the Vertebrate Retina: Experimental Studies and Clinical Relevance." The Loris and David Rich Lecture Series, Dept. of Ophthalmology, University of Alabama, Birmingham, AL.

08/2000 “Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” Department of Ophthalmology & Visual Sciences, University of Wisconsin, Madison, WI

09/2000 “Is that cholesterol in your retina, or are you just happy to see me?” Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, St. Louis, MO

10/2000 “Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” Symposium: Lipid Metabolism and Modifications in Retinal Health and Disease. XIV International Congress of Eye Research (ICER), Sante Fe, NM.

01/2001 “Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” Distinguished Lecture Series, Department of Anatomy, Physiological

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Sciences, and Radiology, School of Veterinary Medicine, North Carolina State University, Raleigh, NC

05/2001 "Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function." Cole Eye Institute, the Cleveland Clinic Foundation, Cleveland, OH.

11/2001 “Teaching and old drug new tricks: Tunicamycin as a tool for quantifying the mixing of new and old proteins in nascent retinal rod outer segment membranes.” 6th Annual Meeting of the Society for Glycobiology, San Francisco, CA

11/2001 Panelist, Session on Chapter Programs in Ethics. “Ethics in the Education of Scientists, Clinicians, and Engineers” 2001 Sigma Xi Annual Meeting, Raleigh, NC.

12/2001 “Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” Cedars Sinai Hospital, Ophthalmology Research, Los Angeles, CA

12/2001 “Effect of cholesterol biosynthesis inhibitors on retinal development, structure, and function.” Emory University, Dept. of Ophthalmology and Visual Sciences, Atlanta, GA

06/2002 “The Retina and Cholesterol Metabolism: Studies with an Animal Model of Human Disease.” National Eye Institute (NEI), Bethesda, MD

06/2002 “The Retina and Cholesterol Metabolism: Studies with an Animal Model of Human Disease.” Department of Biology, San Diego State University, San Diego, CA

07/2002 “The Retina and Cholesterol Metabolism: Studies with an Animal Model of Human Disease.” Department of Cell Biology and the Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK

09/2002 “Cholesterol Metabolism and Retinal Degeneration: Biochemical, Histological, and Functional Correlates in Rodent Models of Human Disease”, Chancellor’s Award Lecture, Louisiana State University, School of Medicine, New Orleans, LA

10/2002 ”A Rodent Model that Mimics the Retinal Abnormalities Associated with the Smith-Lemli-Opitz Syndrome", Xth International Symposium on Retinal Degeneration (RD2002), Burgenstock, Switzerland (Sept. 30-Oct. 5, 2002).

10/2002 “Cholesterol Metabolism and Retinal Degeneration: Biochemical, Histological, and Functional Correlates in Rodent Models of Human Disease”, Department of Biology, California State University, Dominguez Hills, Carson CA

11/2002 "Progressive Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome”, Symposium on Inborn Errors of Cholesterol Synthesis, National Institutes of Health (NICHD), Bethesda, MD (Nov. 14-15, 2002)

06/2003 “Retinal Degeneration in an Animal Model of Smith-Lemli-Opitz Syndrome: Something Old, Something New,” Fifth Scientific Symposium on Smith-Lemli-Opitz Syndrome, The Children’s Hospital, University of Colorado Health Sciences Center, Denver, CO (June 27, 2003)

02/200 Small MS, Keller RK, and Fliesler SJ. A new method for determining cholesterol synthesis in the central nervous system. Poster presentation, HSC Research Day, University of South Florida Health Sciences Center, Tampa, FL (Feb. 26, 2004).

02/2004 “Retinal Degeneration in an Animal Model of Smith-Lemli-Opitz Syndrome: Seeing Past the Metabolic Block in Cholesterol Biosynthesis," Dept. of Biochemistry & Molecular Biology, University of South Florida College of Medicine, Tampa, FL (Feb. 27, 2004).

03/2004 “Retinal Degeneration in an Animal Model of Smith-Lemli-Opitz Syndrome,” Program in Neuroscience and Dept. of Ophthalmology, University of Tennessee Health Sciences Center, Memphis, TN (March 9, 2004)

03/2004 "Studies on Retinal Degeneration in a Rat Model of the Smith-Lemli-Opitz Syndrome", Dept. of Comparative Medicine, Saint Louis University School of Medicine, St. Louis, MO (March 12, 2004)

04/2004 “Defective cholesterol biosynthesis: Is there a link?” Dept. of Physics, Saint Louis University, St. Louis, MO (April 14, 2004).

05/2004 “Defective sterol biosynthesis and retinal degeneration: When bad things happen to nice retinas.” 95th AOCS Annual Meeting & Expo [AOCS/JOCS Joint Symposium

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on Biosciences; BIO 2: Recent Advances in Steroid Research I], Cincinnati, OH (May 9-12, 2004).

08/2004 “Defective Cholesterol Synthesis and Retinal Degeneration: Lessons from an Animal Model of Smith-Lemli-Opitz Syndrome.” Department of Ophthalmology, University of Iowa, School of Medicine, Iowa City, IA (Aug. 12, 2004).

01/2005 “Retinal Degeneration Associated with Defective Cholesterol Biosynthesis.” Departments of Ophthalmology and Veterinary Medicine, Life Sciences Center, University of Missouri-Columbia, Columbia, MO (Jan. 20, 2005)

03/2005 “The Ring Trilogy: Sterols, Membranes, and Disease.” National Institutes of Health (NIH/NICHD), Bethesda, MD (March 4, 2005)

04/2005 “The Ring Trilogy: Sterols, Membranes, and Disease.” Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT (April 21, 2005)

05/2005 “The Ring Trilogy: Sterols, Membranes, and Disease.” Wellman Center for Photomedicine, Massachusetts General Hospital and Dept. of Dermatology, Harvard Medical School, Boston, MA (May 17, 2005).

08/2006 “Retinal Degeneration and Cholesterol Biosynthesis: Animal Model Studies and Therapeutic Intervention.” XXI Annual Congress of the Brazilian Federation of the Societies for Experimental Biology (FeSBE), August 23-27, 2006, Águas de Lindóia, Brazil.

09/2006 ”Retinal Degeneration and Intervention in a Hereditary Dyslipidemia Model.” First Congress, International Society for Ocular Cell Biology (ISOCB), September 6-10, 2006, Homerton College, Cambridge, England.

09/2006 "Cholesterol-Associated Dyslipidemia and Retinal Degeneration: Experimental Studies." Department of Ophthalmology, Ulleval Hospital, University of Norway, Oslo, Norway, Sept. 12, 2006.

09/16/06 "Cholesterol-Associated Dyslipidemia and Retinal Degeneration: Experimental Studies and Possible Therapeutic Intervention.” School of Biological Sciences, University of East Anglia, University Plain, Norwich, England (UK).

09/28/06 "Cholesterol-Associated Dyslipidemia and Retinal Degeneration: Experimental Studies and Possible Therapeutic Intervention.” Department of Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, MO

01/19/07 "Cholesterol Deficiency and Retinal Degeneration: New Insights and Therapeutic Intervention.” Department of Ophthalmology, University of Missouri-Kansas City (UMKC) School of Medicine, Kansas City, MO

02/02/07 "Cholesterol Deficiency and Retinal Degeneration: New Insights and Therapeutic Intervention.” Department of Ophthalmology, University of Texas Health Sciences Center (UTHSC) at San Antonio; San Antonio, TX

03/2007 "Spare the Cholesterol and Spoil the Rod? Retinal Degeneration Caused by Deficient Cholesterol Biosynthesis" Gerald Fishman Lecture Series, Department of Ophthalmology & Visual Sciences, University of Illinois Chicago; Chicago, IL, March 23, 2007.

04/2007 "Hereditary Cholesterol Dyslipidemia and Retinal Degeneration: Experimental Studies and Therapeutic Intervention." Department of Ophthalmology & Visual Sciences, Vanderbilt University School of Medicine, Nashville, TN, April 16, 2007

05/2007 "Cholesterol Deficiency Syndromes: Thinking Beyond What's Missing,” Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL, May 11, 2007.

05/2007 “An Animal Model of Cholesterol Deficiency: Retinal Degeneration and Therapeutic Intervention.” Faculty Seminar Series, Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO (May 25, 2007)

06/2007 “The Molecular and Metabolic Basis of SLOS: Thinking Beyond Sterols.” Conference on Smith-Lemli-Opitz Syndrome (SLOS) and Inborn Errors of Cholesterol Synthesis. Portland, OR (June 28-30, 2007)

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07/2007 "Hereditary Cholesterol Dyslipidemia and Retinal Degeneration: Experimental Studies and Therapeutic Intervention." Department of Ophthalmology, University of Minnesota School of Medicine, Minneapolis, MN (July 20, 2007)

07/2007 "Hereditary Cholesterol Dyslipidemia and Retinal Degeneration: Experimental Studies and Therapeutic Intervention." Department of Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons, New York, NY (July 27, 2007)

08/2007 "Hereditary Cholesterol Dyslipidemia and Retinal Degeneration: Experimental Studies and Therapeutic Intervention." Beckman Vision Research Center, University of California- San Francisco (UCSF), San Francisco, CA (Aug. 17, 2007)

09/2007 “Global Lipidomic and Genomic Alterations and Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome.” Summer ARVO- Ocular Cell & Molecular Biology, Sarasota, FL (Sept. 6-8, 2007)

09/2007 “The Smith -Lemli-Opitz Syndrome: Thinking Beyond Sterols.” The E.A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO (Sept. 19, 2007)

10/2007 “Retinal Degeneration and Hereditary Cholesterol Dyslipidemia: Experimental Studies.” Department of Ophthalmology / Ross Eye Institute, SUNY-Buffalo, Buffalo, NY (Oct. 25, 2007)

11/2007 “Retinal Degeneration and Hereditary Cholesterol Dyslipidemia: Experimental Studies.” Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI (Nov. 1, 2007)

11/2007 “From Lab Benchtop to Clinic: How Scientific Knowledge is Paving the Way for Clinical Trials.” Foundation Fighting Blindness, St. Louis Chapter meeting, St. Louis, MO (Nov. 3, 2007)

11/2007 "The Smith-Lemli-Opitz Syndrome: It's Not Just About Cholesterol," [Grand Rounds] and “Retinal Degeneration in an Animal Model of the Smith-Lemli-Opitz Syndrome” [Research Seminar]; Scheie Eye Institute, Department of Ophthalmology, and the F.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, School of Medicine, Pennsylvania, PA (Nov. 8, 2007)

12/13/07 "Retinal Degeneration and Therapeutic Intervention in an Animal Model of a Cholesterol Deficiency Syndrome." Frontiers in Vision Science Seminar Series, Bascom Palmer Eye Institute (Dept. of Ophthalmology), University of Miami, School of Medicine, Miami, FL

02/08/08 “The Ring Trilogy: Cholesterol, Membranes, and Disease.” Department of Ophthalmology, University of Florida, Gainesville, FL

08/26/08 “The Ring Trilogy: Cholesterol, Membranes, and Retinal Degeneration.” Department of Biochemistry, University at Buffalo (SUNY), Buffalo, NY

09/2008 “Retinal Degeneration in the AY9944-Induced Rat Model of Smith-Lemli-Opitz Syndrome: Biological, Biochemical, and Biophysical Correlates.” Symposium: Retinal Degeneration Mechanisms & Gene Therapy- I, RD2008- XIIIth International Symposium on Retinal Degeneration, Emeishan, China (Sept. 18-23, 2008).

09/2008 “Retinal Degeneration and Therapeutic Intervention in an Animal Model of a Hereditary Cholesterol Deficiency Syndrome.” Symposium: Retinal Diseases- Mechanisms and Treatment; XVIII International Congress of Eye Research (ICER), Beijing, China (Sept. 24-29, 2008)

12/18/08 “The Smith-Lemli-Opitz Syndrome: Thinking Beyond Sterols.” Molecular and Developmental Genetics Seminar Series, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY

06/24/09 “The Smith-Lemli-Opitz Syndrome: It’s NOT Just About Cholesterol.” Department of Ophthalmology, Children’s Hospital Boston/Harvard Medical School, Boston, MA

06/25/09 “The Ring Trilogy: Cholesterol, Membranes, and Retinal Degeneration.” Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, School of Medicine, Boston, MA

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06/2009 “Transcriptional and Proteomic Changes in the Retina in a Rat Model of SLOS: The Effects of Dietary Cholesterol Supplementation.” Scientific Symposium on Smith-Lemli-Opitz Syndrome, Boston, MA (June 26, 2009)

07/2009 “Dealing with Scientific Misconduct: Tales from the Dark Side.” Frontier Science & Technology Research Foundation, Inc. (FSTRF), Amherst, NY (July 20, 2009)

10/2009 “Retinal Degeneration in a Cholesterol Deficiency Syndrome: What We’ve Learned from Animal Studies.” Vision Seminar Series, University of Pennsylvania, School of Medicine, Philadelphia, PA (Oct. 5, 2009).

11/2009 “Impact of Cholesterol Deficiency on Retinal Development, Structure, and Function.” Vision Club, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK. (Nov. 5, 2009)

01/2010 “Retinal Degeneration in a Cholesterol Deficiency Syndrome: What We’ve Learned from Animal Studies.” Grand Rounds, Department of Ophthalmology & Visual Sciences, SUNY Downstate Medical Center, Brooklyn, NY (Jan. 28, 2010)

03/19/10 “Impact of Cholesterol Deficiency on Retinal Development, Structure, and Function.” European Frontiers in Ocular Pharmacology, University of Catania Medical School, Catania, Sicily. (March 19, 2010)

07/2010 “Oxidative and Proteomic Alterations in a Rat Model of Smith-Lemli-Opitz Syndrome, and the Effects of a High-Cholesterol Diet. 2010 Biennial meeting, International Society for Eye Research (Montreal, Canada; July 18-23, 2010); Session RC09- Retinal Crystallins in Health and Disease.

07/27/10 “Cholesterol Deficiency Syndromes: What a Rat Can Tell Us About Human Disease.” University at Buffalo Mini-Medical School Program

09/15/10 “Research Activities at the Ross Eye Institute: An Overview.” Western New York Optometrists Society meeting, Olmstead Center for the Visually Impaired, Buffalo, NY

10/02/10 “Cholesterol Deficiency and Retinal Degeneration: Lessons from the Rat Pack.” Second Annual Meeting, SUNY Eye Institute, SUNY-Upstate Medical School, Syracuse, NY

11/04/10 “Cholesterol Deficiency and Retinal Degeneration: Lessons from the Rat Pack.” Department of Chemistry, Vanderbilt University, Nashville, TN (Nov. 4, 2010)

11/09/10 “The Impact of Defective Cholesterol Synthesis on the Structure and Function of the Retina.” Neuroscience Program, University of Connecticut, Farmington, CT

03/04/11 “Cholesterol Deficiency and Retinal Degeneration: Experimental Studies and Therapeutic Implications.” Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH

04/18/11 “Cholesterol and the Retina: The Good, The Bad, and The Ugly.” VA Western NY Healthcare System Research Seminar Series, Buffalo, NY

05/04/11 “So, You Want to Publish a Paper: Practical Tips and Ethical Guidelines.” 2011 ARVO Workshop, “Getting Published” (Ft. Lauderdale, FL)

06/02/11 “Retinal Degeneration and Cholesterol Deficiency: When Less is More.” Schepens Eye Research Institute, Harvard Medical School, Boston, MA

07/15/11 “Oxidative, Proteomic and Lipid Modifications in the Retina in the AY9944 Rat Model of SLOS.” Scientific Symposium, RSH/Smith-Lemli-Opitz Foundation meeting, Denver, CO.

09/2011 “Cholesterol in the Retina: You Only Miss It When It’s Gone.“ ARVO-ISOCB Ocular Cell Biology Conference, Vancouver, B.C., Canada (Sept. 7-10, 2011)

10/13/11 “Cholesterol Deficiency and Retinal Degeneration: Insights from Experimental Studies.” Harkness Eye Center, Department of Ophthalmology, Columbia University, New York, NY.

02/27/12 “Cholesterol Deficiency and Retinal Degeneration: Insights from Experimental Studies.” 50th Anniversary Symposium, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL (Feb. 2-4, 2012)

03/07/12 “Cholesterol and the Retina: The Good, The Bad, and The Ugly. Department of

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Ophthalmology, University of Florida, Gainesville, FL (Mar. 7, 2012) 05/07/12 “The Impact of Cholesterol Deficiency on Retinal Degeneration: From Basic to

Clinical Research.” ARVO 2012 Minisymposium: Targets for Ocular Neuroprotection: Lost in Translation. Ft. Lauderdale, FL (May 7, 2012)

05/05/12 Course Lecturer, ARVO Workshop: How to Publish a Scientific Paper- A Practical Hands-On Course. Ft. Lauderdale, FL (May 5, 2012)

07/16/12 “Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome is Caspase-Independent and Involves Cathepsin D Upregulation.” RD2012 (XV International Symposium on Retinal Degenerations), Bad Gögging, Regensberg (Bavaria), GE

07/23/12 “Oxysterols and Retinal Degeneration.” XXth Biennial Meeting of the International Society for Eye Research, Berlin, GE

07/26/12 “Defective Cholesterol Biosynthesis: Impact on the Structure and Function of the Retina.” Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

07/30/12 “Defective Cholesterol Biosynthesis: Impact on the Structure and Function of the Retina.” Institute of Ophthalmology, Department of Cell Biology, University College London, London, UK

09/18/12 “From Bench to Bedside (Almost): Lessons from Experimental Studies on a Cholesterol Deficiency Syndrome.” School of Pharmacy and Pharmaceutical Sciences, University at Buffalo-SUNY, Buffalo, NY

10/01/12 "Retinal Degeneration and Cholesterol Deficiency: Insights from Experimental Studies." Department of Ophthalmology / The Eye Institute, Medical College of Wisconsin, Milwaukee, WI

10/03/12 "Retinal Degeneration and Cholesterol Deficiency: Insights from Experimental Studies." Department of Ophthalmology & Visual Sciences, UW Eye Research Institute, University of Wisconsin- Madison, Madison, WI

10/12/12 "Cholesterol Deficiency, Oxidation, and Retinal Degeneration.” 2012 Periopsia Seminar Series, College of Optometry, University of Houston, Houston, TX.

10/23/12 “From Bench to Bedside (Almost): Lessons from Experimental Studies on a Cholesterol Deficiency Syndrome.” MSTP Lecture Series, University at Buffalo, School of Medicine & Biomedical Sciences, Buffalo, NY

01/30/13 “Molecular Insights into Retinal Degeneration in a Cholesterol Deficiency Syndrome”. Department of Medicine, University of California, San Diego (UCSD); San Diego, CA

02/13/13 “Scientific (Research) Misconduct: The Nature of the Beast.” CLIMB Program, UB SMBS, Buffalo, NY.

02/19/13 “Scientific (Research) Misconduct: The Nature of the Beast.” UB Clinical/Research Ethics Seminar Series, Buffalo CTRC, UB SMBS, Buffalo, NY

02/22/13 “Molecular Insights into Retinal Degeneration in a Cholesterol Deficiency Syndrome”. Department of Ophthalmology, Weill Cornell Medical College, New York, NY

03/15/13 “Molecular Insights into Retinal Degeneration in a Cholesterol Deficiency Syndrome”. Department of Medicine, Div. of Endocrinology, SUNY-Buffalo, and Diabetes and Endocrinology Center of Western New York, Buffalo, NY

04/04/13 “Scientific (Research) Misconduct: The Nature of the Beast.” Department of Psychiatry/ Research Group, UB SMBS, Buffalo, NY

05/08/13 “Authorship Ethics: Plagiarism -- Walking on the Dark Side.” ARVO Publishing Workshop- Getting Published: The Good, The Bad, and the Ugly. ARVO Annual Meeting, Seattle, WA.

06/15/13 "The Curious Case of Retinal Degeneration in a Model of a Cholesterol Deficiency Syndrome", Anwar Shah Endowed Lecture, Saint Louis University Eye Institute, Saint Louis University School of Medicine, St. Louis, MO

06/27/13 “On Death and Dying: Retinal Degeneration in the SLOS Rat Model”, 2013 Smith-Lemli-Opitz Scientific Conference, Pittsburgh, PA.

06/29/13 “Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome”, 2013 Smith-Lemli-Opitz Family Conference, Pittsburgh, PA.

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09/09/13 “Molecular Insights into Retinal Degeneration in a Cholesterol Deficiency Syndrome,” Vanzant Lecture Series, Department of Biochemistry & Cell Biology, Rice University, Houston, TX

09/13/13 "Sterols, Oxysterols, and Retinal Degeneration," Vision Research Symposium honoring Joe G. Hollyfield, PhD, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH

09/24/13 “Molecular Insights into Retinal Degeneration in a Cholesterol Deficiency Syndrome,” Chairman's Lecture, Duke Eye Center, Duke University, School of Medicine, Durham, NC

10/23/13 “Through the Looking Glass: The Curious Case of Retinal Degeneration Caused by Defective Cholesterol Synthesis.” Cell Biology Graduate Students Invited Annual Lecture, Dept. of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK

04/11/14 “The Ring Trilogy: Sterols, Membranes, and Retinal Degeneration.” Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY

05/04/14 “Earned Authorship: Giving Credit Where Credit is Due.” ARVO 2014 Publications Workshop- “Authorship Ethics: Credit and Credibility,” Annual Meeting, Association for Research in Vision and Ophthalmology (ARVO), Orlando, FL.

10/02/14 "The Curious Case of Retinal Degeneration in a Model of a Cholesterol Deficiency Syndrome", Dean’s Lecture Series, Dept. of Molecular Biomedical Sciences, North Caroline State University, College of Veterinary Medicine, Raleigh, NC

01/29/15 “The Ring Trilogy: Sterols, Membranes, and Retinal Degeneration.” Dept. of Physiology, University of Arizona, Tucson, AZ

02/12/15 "The Curious Case of Retinal Degeneration in a Model of a Cholesterol Deficiency Syndrome", Developmental Molecular Biology Lecture Series, Roswell Park Cancer Institute, Buffalo, NY

02/17/15 “Plagiarism: Walking on the Dark Side”. Clinical and Research Ethics Series, UB Clinical and Translational Research Center, Buffalo, NY.

03/27/15 “A Decade of Progress in Retinal Degeneration Research: Cage-side to Bedside and Back,” Keynote Lecture, 10th Pro Retina Research Colloquium, Potsdam, Germany.

10/01/15 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” Vision Science Seminar Series, Emory University, Atlanta, GA.

10/08/15 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” Visiting Scholar Seminar Series, John A. Moran Eye Center, University of Utah, Salt Lake City, UT.

10/14/15 “Scientific (Research) Misconduct: The Nature of the Beast.” CLIMB Program, UB SMBS, Buffalo, NY.

01/08/16 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” Visiting Scholar Seminar Series, UAB Vision Science Research Center, The University of Alabama at Birmingham, School of Optometry, Birmingham, AL.

04/14/16 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” Department of Ophthalmology/Cullen Eye Institute, Baylor College of Medicine, Houston, TX.

05/06/16 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA.

05/23/16 “The Ring Trilogy: Cholesterol, Membranes, and Disease.” Department of Biochemistry, Cornell University, Ithaca, NY.

06/10/16 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” Department of Pharmacology and Retina & Vision Group, Case Western Reserve University, School of Medicine, Cleveland, OH.

08/16/16 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology,” James and Jean Culver Vision Discovery Institute Distinguished Seminar Series, Departments of Cellular Biology & Anatomy and Ophthalmology, Augusta University,

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Augusta, GA 09/29/16 Introduction to The 18th Ludwig von Sallmann Prize Lecture, XXII Biennial Meeting of

the International Society for Eye Research (ISER), Tokyo, Japan 11/14/16 “Scientific (Research) Misconduct: The Nature of the Beast”. CLIMB-Hi Graduate

Student Program, SUNY-University at Buffalo/JSMBS, Buffalo, NY 12/13/16 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology.”

MD/PhD Program, Jacobs School of Medicine & Biomedical Sciences, SUNY-University at Buffalo; Buffalo, NY

01/23/17 “Things Your Mother Never Told You About Cholesterol in the Retina.” Scholars in Vision Science Lecture Series, Dept. of Ophthalmology, University of Pittsburgh Medical Center (UPMC); Pittsburgh, PA

03/21/17 “Scientific (Research) Misconduct: The Nature of the Beast”. Clinical and Research Ethics Seminar Series, CTRC, SUNY-University at Buffalo/JSMBS, Buffalo, NY

03/24/17 “Cholesterol and the Retina: Twists and Turns of Biology and Pathobiology.” Department of Biology, Georgia State University, Atlanta, GA.

03/27/17 “Responsible Conduct in Research: An Overview.” CTSI Workshop 05/07/17 “Selecting the Right Journal for Your Publication: Options and Considerations.”

ARVO Publications Committee Workshop- How to Write and Publish a High Impact Vision Research Article: The Dos and Don’ts. 2017 ARVO Annual Meeting, Baltimore, MD.

05/09/17 “Rescue of Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome.” Paper Session #308: Photoreceptors: Cell Biology, Disease and Rescue. 2017 ARVO Annual Meeting, Baltimore, MD.

06/22/17 “Retinal Degeneration and Rescue in a Rat Model of Smith-Lemli-Opitz Syndrome.” Smith-Lemlii-Opitz Syndrome Scientific Conference, Covington, KY.

07/28/17 “Cholesterol and the Retina: The Never-ending Story.” Dept. of Pharmacotherapy, Washington State University, College of Pharmacy, Spokane, WA.

10/20/17 “Retinal Degeneration and Rescue in an Animal Model of Smith-Lemli-Opitz Syndrome (SLOS).” 15th Annual Buffalo Continuing Education Program, Association of Technical Personnel in Ophthalmology (ATPO), Buffalo, NY.

11/07/17 “Research Misconduct: The Nature of the Beast.” CLIMB Program, Professional Development Catalyst (PDC) Workshop series, University at Buffalo.

11/13/17 “Cholesterol and the Retina: The Never-ending Story.” Dean’s Award Lecture in Neuroscience and Ophthalmology, LSU Health Sciences Center, New Orleans, LA

01/27/18 “Conflicts of Interest.” Workshop: Research Considerations in the Clinical Setting. AUPO2018 (Annual Meeting, Association of University Professors of Ophthalmology); Austin, TX; January 24-27, 2018.

04/10/18 “The Latest in Eye Research”, UB Mini-Med School, Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY

06/22/18 “Retinal Degeneration and Rescue in an Animal Model of Smith-Lemli-Opitz Syndrome (SLOS).” F. Hoffmann-La Roche AG, Basel, Switzerland.

06/26/18 “Retinal Degeneration and Rescue in an Animal Model of Smith-Lemli-Opitz Syndrome (SLOS).” Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.

07/30/18 “Research Misconduct: The Nature of the Beast.” RCR Program, Keck School of Medicine of USC, Los Angeles, CA.

07/31/18 “Authorship Ethics.” RCR Program, Keck School of Medicine of USC, Los Angeles, CA.

07/30/18 “Retinal Degeneration and Rescue in an Animal Model of Smith-Lemli-Opitz Syndrome (SLOS).” Distinguished Ophthalmology Lecture Series, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, CA.

07/31/18 “Cholesterol: Twists and Turns of Biology and Pathobiology in the Retina.” Jules and Doris Stein Lectureship, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.

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09/17/18 “Cholesterol: Twists and Turns of Biology and Pathobiology in the Retina.” The Wilmer Science Seminar Series, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

10/05/18 “SLOS, Oxysterols, and Retinal Homeostasis.” Platform Session: “Cholesterol, Oxysterols and Eye Disease,” EVER 2018 Congress, European Association for Vision and Eye Research; Nice, France; October 4-6, 2018.

10/25/18 “Retinal Degenerations: The Isoprenoid Connection.” Plenary Lecture, Sociedad Argentina de Investigación en Neurosciencias (SAN) XXXIII Annual Congress, Cordoba, Argentina, October 23-26, 2018.

02/14/19 “Retinal Degenerations: The Isoprenoid Connection.” Bascom Palmer Eye Institute / University of Miami Miller School of Medicine; Miami, FL. February 14, 2019

03/22/19 “Retinal Degenerations: The Isoprenoid Connection.” Distinguished Visiting Lecture, Center for Translational Vision Research, The Gavin Herbert Eye Institute / Department of Ophthalmology, University of California- Irvine (UCI) School of Medicine; Irvine, CA.

04/04/19 “Retinal Degenerations: The Isoprenoid Connection.” Grand Rounds, Distinguished Visiting Professor Lecture, Department of Ophthalmology, University of California, San Francisco (UCSF); San Francisco, CA.

04/07/19 “Retinal Degenerations: The Isoprenoid Connection.” Department of Ophthalmology, Fudan University, School of Medicine; Shanghai, China.

04/09/19 “Retinal Degenerations: The Isoprenoid Connection.” Department of Ophthalmology, Wenzhou Medical University; Wenzhou, China.

04/10/19 “Retinal Degenerations: The Isoprenoid Connection.” The Nanqiang Memorial Lecture, Department of Ophthalmology, Eye Institute of Xiamen University; Xiamen, China.

04/11/19 “Publishing Ethics and Tips for Success for Getting Published.” Plenary Lecture, Publishing Workshop, 11th Chinese Congress of Research in Vision and Ophthalmology (CCRVO), Xiamen, China.

04/29/19 “Authorship Ethics: Plagiarism- Walking on the Dark Side.” ARVO Publishing Workshop, “Getting Published: The Light and Dark Side.” 2019 ARVO Annual Meeting, Vancouver, B.C.

05/02/19 “Rethinking Therapy for Cholesterol Deficiency Syndromes.” SIG: Lipids and Eye Diseases- Where Should We Focus?” 2019 ARVO Annual Meeting, Vancouver, B.C.

05/23/19 “Cholesterol and Oxysterols in the Retina: Friends or Foes?” The Sydney Futterman Memorial Lecture in Ophthalmology, Department of Ophthalmology, University of Washington, School of Medicine, Seattle, WA. May 23, 2019.

06/07/19 “Improved Therapeutic Intervention for Smith-Lemli-Opitz Disease: Bench to (Almost) Bedside?” Annual Buffalo Ophthalmology Symposium; Buffalo, NY.

06/11/19 “Retinal Degenerations: The Isoprenoid Connection.” Department of Pharmacology, , University of Alberta, Faculty of Medicine & Dentistry; Edmonton, Alberta, CAN.

06/12/19 “Retinal Degenerations: The Isoprenoid Connection.” Department of Cell Biology and Anatomy, University of Calgary, Cumming School of Medicine; Calgary, Alberta, CAN. June 12, 2019.

SERVICE TO THE PROFESSION:

1. Federal and Private Grant Peer Review Panels, and Advisory Committees 1985 1985 Ad hoc Reviewer, VIS A2 Study Section (NEI/NIH) 1985-87 1985-87 Ad hoc Reviewer, Research to Prevent Blindness, Inc.

Ad hoc Reviewer, Society for the Prevention of Blindness 1986 1986 Ad hoc Reviewer, Fogarty International Awards Review Group (NIH) 1987 1987 Ad-Hoc Reviewer (AHR-01), VIS- B Study Section (NEI/NIH) 1989 1989 Reviewer, National Science Foundation (NSF)

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Ad Hoc Member, National Eye Institute (NEI) Board of Scientific Counselors, 1990 1990 Reviewer, RP Eye Research Foundation (Canada)

Reviewer, National Science Foundation (NSF) Consultant, Retinal Diseases Panel, National Advisory Eye Council Five-Year Plan

1991 1991 Reviewer, National Science Foundation (NSF) 1992-94 1992-94 Member, Grants-In-Aid Review Panel, Fight For Sight, Inc. (National Society to Prevent

Blindness) 1992 1992 Reviewer, Eppley Foundation for Research (New York) 1993 1993 Reviewer, North Carolina Biotechnology Center

1998 - Member, Cell Biology Review Panel, Foundation Fighting Blindness 1998 Member, Center Grant Review Panel and Site Visit Team, Foundation Fighting

Blindness 2000- Reviewer, Center Grant Panel, Foundation Fighting Blindness 2001- Ad hoc Member, Board of Scientific Counselors, National Eye Institute [Review of the Laboratory of Retinal Cell and Molecular Biology; Dec., 2001] 2002- Ad hoc Member, VIS-C Study Section, National Eye Institute (Feb., June); BDPE

Study Section (Oct., 2003); Member, Advisory Panel for Research Agenda, State of Missouri Department of Health and Senior Services (DHSS), Division of Maternal, Child, and Family Health (MCFH)

2003 Ad hoc Member, VIS-C Study Section, National Eye Institute (Feb., June); BDPE Study Section (Oct., 2003)

2004 Ad hoc Member, BDPE Study Section (Feb., June, 2004) 2005 Ad hoc Member, NEI Special Emphasis Panel (SEP CB-G (90), Retinopathy; Oct.,

2005) 2005-07 Member, CITI Developers’ Group, Responsible Conduct in Research web-based

course (Co-Developer: Authorship and Peer Review Modules) 2006- Member, American Health Assistance Foundation (AHAF) Macular Degeneration

Research Review Panel (Jan. 2006-2008); Member, Fight for Sight Grants Review Panel (2006-2009)

2007- Ad hoc Member, SBIR Review Panel, NIH/NEI (March, 2007); Regular Member, BDPE Study Section, NIH/NEI (2007-2011); Ad hoc reviewer, International Retinal Research Foundation, Inc. (IRRF) (April 2007); Ad hoc reviewer/Study Section Chair, American Institute of Biological Sciences (AIBS) / National Neurovision Research Institute (NNRI) (May 2007).

2007 Regular Member, BDPE Study Section, NIH/NEI (2007-2011) 2009 Regular Member, BDPE Study Section, NIH/NEI (2007-2011); Ad hoc review panel

member, Israel Cancer Research Fund; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Steering Committee, SUNY Eye Institute (SEI)

2010 Regular Member, BDPE Study Section, NIH/NEI (2007-2011); Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR) consortium, Oregon Health & Science University; Advisor to the X Prize Foundation- Vision Restoration.

2011 Regular Member, BDPE Study Section, NIH/NEI (2007-2011); Member & Co-Chair, BDPE-J Study Section (Jan. 2011 mtg); Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR) consortium, Oregon Health & Science University;

2012 Member, Ocular Study Oversight Committee (OSOC), University of Wisconsin-Madison; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR) consortium, Oregon Health & Science University; Member, Beckman Initiative for Macular Research

2013 Member, Ocular Study Oversight Committee (OSOC), University of Wisconsin-Madison; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR)

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Consortium, Oregon Health & Science University; Member, Beckman Initiative for Macular Research; Ad hoc Reviewer, Medical Research Council (MRC), MCMB Grants Panel (U.K.); Ad hoc Reviewer, Singapore Medical Research Council

2014 Member, Ocular Study Oversight Committee (OSOC), University of Wisconsin-Madison; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR) Consortium, Oregon Health & Science University; Member, Beckman Initiative for Macular Research; Ad hoc Reviewer, Macular Society (U.K.); ARVO Board of Trustees Member-Elect; Ad hoc Reviewer, NIH/CSR BVS Study Section (June 2014); Ad hoc reviewer, UK SBS grant review panel (July 2014).

2015 Member, Ocular Study Oversight Committee (OSOC), University of Wisconsin-Madison; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR) Consortium, Oregon Health & Science University; Member, BrightFocus Foundation FY16 Macular Degeneration Research Scientific Review Committee; Member, Foundation Fighting Blindness (FFB) Cellular and Molecular Mechanisms (CMM) Grant Review Committee; Member, Scientific Advisory Board, Foundation Fighting Blindness (FFB); Reviewer, International Retinal Research Foundation (IRRF)

2016 Member, Ocular Study Oversight Committee (OSOC), University of Wisconsin-Madison; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Scientific Advisory Committee (SAC) for the Sterol and Isoprenoid Research (STAIR) Consortium, Oregon Health & Science University; Member, BrightFocus Foundation FY16 Macular Degeneration Research Scientific Review Committee; Member, Foundation Fighting Blindness (FFB) Cellular and Molecular Mechanisms (CMM) Grant Review Committee; Member, Scientific Advisory Board, Foundation Fighting Blindness (FFB)

2017 Member, Ocular Study Oversight Committee (OSOC), University of Wisconsin-Madison; Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Foundation Fighting Blindness (FFB) Cellular and Molecular Mechanisms (CMM) Grant Review Committee; Member, Scientific Advisory Board, Foundation Fighting Blindness (FFB); Member, Grants Review Panel- Individual Investigator Awards, FFB; Member, Fight for Sight (FFS) Grants-in-Aid, Student Summer Fellowships and Postdoctoral Fellowships Review Panels; Ad hoc Member, RR&D/Department of Veterans Affairs SPiRE Review Panel; Member, Ad hoc Member, NEI/NIH R24 Study Section (Special Emphasis Panel); Ad hoc reviewer, International Retina Research Foundation (IRRF).

2018 Member, Program Review Panel, Congressionally Directed Medical Research Program (CDMRP) Vision Research Program (VRP); Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Foundation Fighting Blindness (FFB) Cellular and Molecular Mechanisms (CMM) Grant Review Committee; Member, Scientific Advisory Board, Foundation Fighting Blindness (FFB); Member, Grants Review Panel- Individual Investigator Awards, FFB; Member, Fight for Sight (FFS) Grants-in-Aid, Student Summer Fellowships and Postdoctoral Fellowships Review Panels; Member, NEI/NIH R24 Special Emphasis Panel

2019 Member, Program Review Panel, Congressionally Directed Medical Research Program (CDMRP) Vision Research Program (VRP); Member, Medical Advisory Board, SLOS/RSH Foundation; Member, Foundation Fighting Blindness (FFB) Cellular and Molecular Mechanisms (CMM) Grant Review Committee; Member, Scientific Advisory Board, Foundation Fighting Blindness (FFB); Member, Grants Review Panel- Individual Investigator Awards, FFB;

2. Editorial Boards and Journal Peer Review Activities:

A. Editorial Board Memberships

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Glycobiology (Founding Editorial Board Member) (1990- 2000): Experimental Eye Research: Executive Editorial Board (1995- present); Retina and Choroid

Section Editor (2001- present); Focus on Molecules Feature Editor (2005-12); Reviews and Special Issues Editor (2012-2018); Editor-in-Chief (2018 – present); Guest Editor: Role of Lipid and Protein Oxidation in Retinal Degenerations

Journal of Lipid Research (June 2004-present); Thematic Series Editor: Lipids and Lipid Metabolism in the Eye (2010)

Journal of Ocular Biology, Diseases and Informatics (April 2007- present) Journal of Membrane Science & Technology (June 2010- present) Molecular Vision (March 2011- present) OMICS Anatomy & Physiology (June 2011-present) OMICS Hereditary Genetics (July 2011-present) Annual Review & Research in Biology (SCIENCEDOMAIN International) (Mar. 2013 – present) Eye and Brain (Aug. 2013 - present)

B. Journal Peer Review Activities: 1985: American Journal of Ophthalmology; Cell and Tissue Research; Experimental Eye

Research; Investigative Ophthalmology and Visual Science 1986: Experimental Eye Research

1987: Experimental Eye Research; Current Eye Research; Journal of Neurochemistry 1988: American Journal of Ophthalmology; Current Eye Research; Experimental Eye

Research; Journal of Neurochemistry 1989: Experimental Eye Research; Investigative Ophthalmology and Visual Science;

Science 1990: Current Eye Research; Experimental Eye Research; Glycobiology; Investigative

Ophthalmology and Visual Science; Science 1991: Biochimica et Biophysica Acta; Brain Research; Current Eye Research; Experimental

Eye Research; Glycobiology; Investigative Ophthalmology and Visual Sciences; Journal Cell Biology; Progress in Veterinary and Comparative Ophthalmology

1992: Brain Research; Current Eye Research; Experimental Eye Research; Glycobiology; Investigative Ophthalmology and Visual Sciences; Journal of Neurocytology

1993: Behavioral and Brain Sciences; Current Eye Research; Experimental Eye Research; Glycobiology; Investigative Ophthalmology and Visual Sciences; Journal Neurochemistry; Journal of Neuroscience Research

1994: Behavioral and Brain Sciences; Experimental Eye Research; Glycobiology; Investigative Ophthalmology and Visual Sciences; Vision Research

Special Editor: Experimental Eye Research 1995: Experimental Eye Research Glycobiology; Investigative Ophthalmology and Visual

Sciences; Vision Research 1996: Experimental Eye Research; Glycobiology; Investigative Ophthalmology & Visual

Sciences (IOVS); Journal of Neurochemical Research; Journal of Neurochemistry; Journal of Neuroscience; Stroke; Vision Research

1997: American Journal of Ophthalmology; Archives of Ophthalmology; Experimental Eye Research; Glycobiology; Investigative Ophthalmology & Visual Sciences (IOVS); Journal of Cell Science; Journal of Neurochemistry; Journal of Neuroscience; Neuroscience; Neuroscience Letters

1998: American Journal of Ophthalmology; Comparative Biochemistry and Physiology; Current Eye Research; Experimental Eye Research; Glycobiology; Investigative Ophthalmology & Visual Sciences (IOVS); Journal of Neurochemistry; Proceedings of the National Academy of Science (PNAS); Vision Research

1999: American Journal of Ophthalmology; Biochemistry; Biochimica et Biophysica Acta; Experimental Eye Research; GENE; Glycobiology; International Journal of Biochemistry and Cell Biology; Investigative Ophthalmology & Visual Sciences (IOVS); Guest Editorial Board Member: Invest. Ophthalmol.Vis. Sci. (IOVS)

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2000: American Journal of Ophthalmology; Current Eye Research; Experimental Eye Research; Glycobiology; Investigative Ophthalmology & Visual Sciences; Journal of Chromatography;

Guest Editorial Board Member: Investigative Ophthalmology & Visual Sciences 2001-02: American Journal of Ophthalmology; Cell Motility and the Cytoskeleton; Current Eye

Research; Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Biological Chemistry; Journal of Comparative Neurology; Molecular Vision; Neuroscience;

Guest Editorial Board Member: Investigative Ophthalmology & Visual Sciences 2002-03: Archives of Biochemistry and Biophysics; Experimental Eye Research; Investigative

Ophthalmology & Visual Sciences; Journal of Biological Chemistry; Regulatory Peptides; Steroids

Guest Editorial Board Member: Investigative Ophthalmology & Visual Sciences 2003-04: Biochemistry; Experimental Eye Research; Investigative Ophthalmology & Visual

Sciences; Journal of Comparative Neurology; Journal of Experimental Biology & Medicine; Journal of Lipid Research; Steroids;

Guest Editorial Board Member: Investigative Ophthalmology & Visual Sciences 2004-05: Archives of Biochemistry & Biophysics; Current Eye Research; Experimental Eye

Research; FASEB J.; International Journal of Biochemistry & Cell Biology; Investigative Ophthalmology & Visual Sciences; Journal of International Association of Medical Science Educators (JIAMSE); Journal of Lipid Research; Journal of Neuroscience; Molecular Genetics and Metabolism; Molecular Vision; Neuron Glia Biology; Proceedings of the National Academy of Sciences;

2006: Biochemistry; Current Eye Research; Experimental Biology and Medicine; Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Journal of Neurochemistry; Journal of Pediatric and Developmental Pathology; Lipids; Science and Engineering Ethics; Trends in Endocrinology & Metabolism

2007: Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Photochemistry & Photobiology; Proceedings of the National Academy of Sciences; Science & Engineering Ethics; Trends in Endocrinology & Metabolism

2008: Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Molecular Vision; Pediatric Res.

2009: Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Lipids; Molecular Vision; Thematic Series Editor (Lipids and Lipid Metabolism in the Retina), Journal of Lipid Research; Proceedings of the National Academy of Sciences

2010: Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; J. Neurochem.; Photochem. Photobiol.; Thematic Series Editor (Lipids and Lipid Metabolism in the Retina), Journal of Lipid Research; Proceedings of the National Academy of Sciences

2011: Experimental Eye Research; FASEB J.; Investigative Ophthalmology & Visual Sciences; Journal of Biological Chemistry; Journal of Lipid Research; Lipids; Molecular Vision; Photochemistry & Photobiology

2012: Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Journal of Lipids; Lipids; Molecular Vision; PLoS One; Translational Vision Science & Technology

2013 Annual Review & Research in Biology; Chemical Research in Toxicology; Environmental Health Perspectives; Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Lipids; Molecular Vision; PLoS One; Journal of Cell Science

2014 BBA - Molecular and Cell Biology of Lipids; Cellular and Molecular Life Sciences; Cellular and Molecular Neurobiology; Clinical Genetics; Environmental Health

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Perspectives; Experimental Eye Research; Expert Opin Orphan Drugs; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Molecular Vision; Nature Medicine; Nano Letters; PLoS One; Pediatric Research.; Progress in Retina and Eye Research

2015 Experimental Eye Research; FASEB Journal; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Molecular Vision; Nature Medicine; PLoS One.

2016 Chemical Research in Toxicology; Experimental Eye Research; Investigative Ophthalmology & Visual Sciences; Journal of Lipid Research; Molecular Vision; Nature Medicine; Progress in Retina and Eye Research.

2017 American Journal of Perinatology; Cellular and Molecular Neurobiology; EBioMedicine; Experimental Eye Research; International Journal of Nanomedicine; Investigative Ophthalmology & Visual Sciences (IOVS); Journal of Biological Chemistry (JBC); Journal of Lipid Research (JLR); Journal of Neurotrauma; Metabolomics; Molecular Vision; Scientific Reports (Nature); Trends in Endocrinology & Metabolism (Cell Press); Vascular Health and Risk Management

2018 Autophagy; BMC Developmental Biology; Experimental Eye Research; Investigative Ophthalmology & Visual Sciences (IOVS); Journal of Lipid Research (JLR); Molecular Vision; Proc. Natl. Acad. Sci. U.S.A.

2019 Autophagy; eLife; Experimental Cell Research; Experimental Cell Research; Experimental Eye Research; Investigative Ophthalmology & Visual Sciences (IOVS); Journal of Inherited Metabolic Disease; Journal of Lipid Research (JLR); Molecular Vision; Scientific Reports

3. Professional Society Activities: 1986 Organizer and Chairman, Minisymposium: "Carbohydrates and Outer Segment-RPE

Interactions," VII International Congress of Eye Research, Nagoya, Japan (Sept. 25 - Oct. 1)

1988 Co-moderator, ARVO Retinal Cell Biology Section: "Retinal Degeneration, Association for Research in Vision and Ophthalmology (ARVO), Sarasota, FL (May 1-6, 1988)

1988 Organizer and Co-chairman, Minisymposium: "Glycoconjugates in the Retina and Pigment Epithelium: Identification and Functions," VIII International Congress of Eye Research, San Francisco, CA (Sept. 4-8)

1989 Consultant to the Program Planning Committee, 1989 Miami Winter/Biotechnology Symposium: "Advances in Gene Technology: Molecular Neurobiology and Neuropharmacology," Miami, FL (Feb. 6-10)

1989 Chairman, Sensory Systems and Transduction Session, 1989 Miami Winter/Biotechnology Symposium, Miami, FL (Feb. 6-10)

1990 Co-moderator, ARVO Retinal Cell Biology Section: "Photoreceptor Shedding and Renewal," ARVO, Sarasota, FL (April 29 - May 4)

1990-93 Member, Program Planning Committee, Retinal Cell Biology Section, Association for Research in Vision and Ophthalmology (ARVO); Chairperson, 1992

1991 Co-moderator, ARVO Retinal Cell Biology Section: "Photoreceptors", ARVO, Sarasota, FL (April 28 - May 3)

1991 Co-moderator, "Cell Signaling and Essential Fatty Acids: Cross-Talk Between Receptors and Messengers", Fidia Research Foundation Symposium, "Neurobiology of Essential Fatty Acids", Cairns, Australia (July 10-12)

1992 Co-moderator, ARVO Retinal Cell Biology Section sessions: "Photoreceptors, Membranes and Renewal"; "Extracellular and Interphotoreceptor Matrices"; and "Retinal Pigment Epithelium", ARVO, Sarasota, FL (May 3-8)

1992 Co-Organizer and Co-Chair, Minisymposium: "Glycosyltransferases and Glycoconjugates of the Retina and Retinal Pigment Epithelium," Xth International Congress of Eye Research (ICER), Stresa, Italy (Sept. 21-25)

1993 Co-moderator, ARVO Joint Topics Session (Biochemistry and Retinal Cell Biology), "Photoreceptors: Cellular and Molecular Aspects," ARVO, Sarasota, FL (May 1-8)

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1994 Co-moderator, ARVO Retinal Cell Biology Section Session: "Photoreceptor Outer Segment Assembly and Phagocytosis," ARVO, Sarasota, FL (May 1-6)

1994 Moderator, Symposium in honor of Professor Adolph Cohen, Washington University School of Medicine, St. Louis, MO (Sept. 17)

1999 Session Chair, George J. Schroepfer, Jr., Memorial Symposium on the Biochemistry of Sterols and Steroids, 1999 Annual Meeting, American Oil Chemists’ Society, Orlando, FL (May 9-12)

2000 Organizer and Co-Moderator, Mini-Symposium: “Lipid Metabolism and Modifications in Retinal Health and Disease”, XIV International Congress of Eye Research (ICER), Santa Fe, NM (October 15-20, 2000)

2001-03 President, Sigma Xi, Saint Louis University Chapter (#SE 089) 2001 Co-Organizer and Session Moderator, Sigma Xi Ethics Workshop: “Ethics in the

Education of Scientists, Clinicians, and Engineers” (February 8, 2001, Saint Louis University Health Sciences Center, St. Louis, MO)

2002 Co-Moderator, ARVO Mini-Symposium: Genetics of Retinal Degeneration, ARVO, Ft. Lauderdale, FL (May 4-10)

Membership Committee, International Society for Eye Research (ISER) (July, 2002-2005) Co-Chair, Platform Session: “Mechanisms of Retinal Degeneration and Cell Death,” Xth International Symposium on Retinal Degeneration (RD2002), Burgenstock, Switzerland (Sept. 30-Oct. 5, 2002)

2004 Councilor for North America, International Society for Eye Research (ISER) (Jan. 1, 2004-Dec. 31, 2007) Organizer and Co-Moderator, Mini-Symposium: “Oxidative Damage and Signal Transduction in the Retina,” XVI International Congress of Eye Research (ICER), Sydney, Australia (Aug. 29-Sept. 3, 2004).

2006 Member, Kayser Award Review Panel, International Society for Eye Research (ISER); Council Liaison to Membership Committee, ISER.

2007- Treasurer, International Society for Eye Research (ISER); Council Liaison to Membership Committee, ISER; Executive Committee Member, ISER

2008- Co-Organizer, Retinal Neuroscience Program, 2008 International Congress of Eye Research (ICER), Beijing, China (Sept. 2008)

2009- Co-Program Organizer, ARVO/ISOCB (International Society for Ocular Cell Biology), Ericeira, Portugal (Sept. 2009)

2010-11 President-Elect, International Society for Eye Research (ISER) 2010- Member, ARVO Publications Committee; Session Co-Moderator, “Carotenoids and

Oxidative Stress,” RD2010 (XIVth Symposium on Retinal Degeneration, Mont-Tremblant, Quebec, Canada, July 13-17, 2010)

2011 Organizer/Moderator/Speaker: 2011 ARVO Workshop (May 4, 2011), “Getting Published”; Member, ARVO Publications Committee; Elected to the Annual Meeting Program Planning Committee, Retinal Cell Biology (RC) Section, ARVO (3-yr term); Session Moderator, ARVO/ISOCB Meeting (Sept. 7-11, 2011, Vancouver, BC)

2012 Member, ARVO Annual Meeting Planning Committee (RC Section); Member, ARVO Publications Committee (Chair-Elect; Chair, 05/12-05/15); President, International Society for Eye Research (ISER; 2012-14); Session Organizer & Co-Moderator, “Oxidative Stress and Retinal Degeneration”, XXth ISER Biennial Meeting (Berlin, GE); Moderator, ARVO 2012, RC Poster session.

2013 Member, ARVO Annual Meeting Planning Committee (RC Section; Chair, 05/13-05/14); Member, ARVO Publications Committee (Chair, 05/13-05/15); Member, ARVO Panel on Open-Access Publishing (Advisory to ARVO Board of Trustees); Moderator, ARVO Annual Meeting: Poster Session- “Retinal and Photoreceptor Degeneration I: Cell Biology”; Platform Session- “ER Stress and the Unfolded Protein Response in Ocular Health and Disease”; Organizer/Co-Moderator/Speaker, ARVO Publications Committee Workshop- “Getting Published: The Good, the Bad, and the Ugly;”

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President, International Society for Eye Research (ISER; 2012-14); Program Organizing Committee, RSH/SLOS Scientific Symposium (Pittsburgh, PA; June, 2013); Nominee, ARVO Trustee, Retinal Cell Biology (RC) Section.

2014 Member, ARVO Annual Meeting Planning Committee (Chair, RC Section); Member, ARVO Publications Committee (Chair, 05/13-05/15); 2014 ARVO Annual Meeting: Co-Moderator, Cross-Sectional Symposium- “Autophagy and Proteolysis in Ocular Health and Disease”; Co-Moderator, Cross-Sectional Symposium- “Genetics and the Pathophysiology of AMD: From SNPs to Disease Modeling”; Organizer/Co-Moderator/Speaker, ARVO Publications Committee Workshop- “Authorship Ethics: Giving Credit Where Credit is Due;” Co-Moderator, ISER Biennial Meeting platform session RC07: Unfolded Protein Response in Oxidative Stress and Retinal Degenerations; President, International Society for Eye Research (ISER; 2012-15); ARVO Board of Trustees (elected 05/14), Retinal Cell Biology (RC) Section (2014-19); Member, ARVO Scientific Publishing Advisory Group.

2015 Member, ARVO Publications Committee (Chair, 05/13-05/15); Member, ARVO Board of Trustees, Retinal Cell Biology (RC) Section (2014-19); Member, ARVO Scientific Publishing Advisory Group; Member, ARVO Board EIC Nominating Committee; member, ARVO Research Training Planning Committee; President, International Society for Eye Research (ISER; 2012-15);

2016 Member, ARVO Board of Trustees, Retinal Cell Biology (RC) Section (2014-19); Board of Trustees Liaison (ex officio) to the ARVO Publications Committee; Member, ARVO Scientific Publishing Advisory Group; Immediate Past President, International Society for Eye Research (ISER); Co-Organizer/Co-Moderator, Retinal Cell Biology Session: “Oxidative and ER Stress in Retinal Degenerations”, XXII ISER Biennial Meeting (Tokyo, Japan; Sept. 2016); Member, AUPO Publications Committee

2017 ARVO: Member, Board of Trustees, Retinal Cell Biology (RC) Section (2014-19); Member, Executive Committee; Board of Trustees Liaison (ex officio) to the ARVO Publications Committee; Member, ARVO Commercial Relationships Policy Working Group; Member, ARVO IOVS Working Group; Member, ARVO Strategic Planning Committee; Member/Mentor, ARVO Global Mentoring Program; President-elect (May 2017-18); Co-Moderator, Platform Session: “Photoreceptors: Cell Biology, Disease, and Rescue,” 2017 ARVO Annual Meeting (Baltimore, MD). Other: Board Member (2017-20), AEVR (Alliance for Eye and Vision Research); Board Member (2017-20), NAEVR (National Alliance for Eye and Vision Research). Member, AUPO Prize Selection Committee, RPB David F. Weeks Award for Outstanding AMD Research.

2018 ARVO: President (May 2018-19); Member, Board of Trustees, Retinal Cell Biology (RC) Section (2014-19); Member, Executive Committee; Board of Trustees Liaison (ex officio) to the ARVO Publications Committee; Member, ARVO Strategic Planning Committee; Member/Mentor, ARVO Global Mentoring Program; Member, ARVO B2B (Bench to Bedside) Working Group; Member (ex officio), ARVO Finance Committee. Other: Board Member (2017-20), AEVR (Alliance for Eye and Vision Research); Board Member (2017-20), NAEVR (National Alliance for Eye and Vision Research); Member, AUPO Prize Selection Committee, RPB David F. Weeks Award for Outstanding AMD Research.

2019 ARVO: President (May 2018-19); Immediate Past President (May 2019-20) Member, Board of Trustees, Retinal Cell Biology (RC) Section (2014-20); Member, Executive Committee; Board of Trustees Liaison (ex officio) to the ARVO Publications Committee; Member, ARVO Strategic Planning Committee; Member/Mentor, ARVO Global Mentoring Program; Member, ARVO International Working Group; Member, ARVO Professional Code of Conduct Working Group; Member, ARVO B2B (Bench to Bedside) Working Group; Member (ex officio), ARVO Finance Committee. Other: Board Member (2017-20), AEVR (Alliance for Eye and Vision Research); Board Member (2017-20), NAEVR (National Alliance for Eye and Vision Research); Member, AUPO Prize Selection Committee, RPB David F. Weeks Award for Outstanding AMD

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Research.; Member, ASCB International Affairs Committee (2019, Jan.-Dec.); Co-Moderator, SIG: Publishing Workshop, 11th Chinese Congress of Research in Vision and Ophthalmology (CCRVO), Xiamen, China; Co-Moderator, SIG: “Lipids and Eye Diseases- Where Should We Focus?” 2019 ARVO Annual Meeting, Vancouver, B.C.

SERVICE TO THE PUBLIC: 1993 Participant, “Scientists at the Center” Workshop, St. Louis Science Center 1993-1997 Yearly lectures and cow eye dissection demonstrations, Highcroft Ridge School,

Chesterfield, MO (host: Ms. Gail Berwald, science & Gifted Program teacher) 1997 Designated national representative, Sigma Xi, Inauguration of Dr. Dale

Nitzschke, President, Southeast Missouri State Univ., Cape Girardeau, MO 1997 Judge, Graduate Student Association (GSA) 3rd Annual Research Day

Symposium (for the GSA and for Sigma Xi), Saint Louis University 1998- 2008 Lectures and cow eye dissection demonstrations, Practical Anatomy and

Surgical Workshop of St. Louis, “Adventures in Medicine and Science” (AIMS) Program

1998 Member, St. Louis Host Committee, NEI/NIH “VISION: A Traveling Exhibit”, St. Louis Science Center

1999 Lecture and cow eye dissection demonstration, Brittany Woods School, University City, MO

1999-2008 Member, Lafayette Square Community Garden Group 1999 Judge, Graduate Student Association (GSA) 5th Annual Graduate Research Day

symposium (for the GSA and for Sigma Xi), Saint Louis University 2000 Judge, Graduate Student Association (GSA) 6th Annual Graduate Research Day

Symposium (for Sigma Xi), Saint Louis University 2001 Judge, Crossroads School Science Fair, St. Louis, MO; Judge, Graduate Student

Association (GSA) 7th Annual Graduate Research Day Symposium (for Sigma Xi), Saint Louis University

2001 Video teleconference (Dec. 6, 2001), ocular anatomy and cow eye dissection, Cooperating School Districts (CSD) of Greater St. Louis, MO

2001 Ocular anatomy and cow eye dissection (Dec. 10, 2001), Crossroads School, St. Louis, MO

2002 Judge, GSA 8th Annual Graduate Research Day Symposium (Saint Louis University); Walk America (for March of Dimes, April 27, 2002, St. Louis, MO)

2002 Judge, GSA 9th Annual Graduate Research Day Symposium (Saint Louis University)

2003 Judge, GSA 10th Annual Graduate Research Day Symposium (Saint Louis University)

2004 Judge, GSA 11th Annual Graduate Research Day Symposium (Saint Louis University) ; Volunteer, Off and Running Program, Temple Israel, St. Louis, MO; Member, Interfaith Partnership of Metropolitan St. Louis

2005 Judge, GSA 12th Annual Graduate Research Day Symposium (Saint Louis University) Co-Leader, Lafayette Square Community Garden; Guide/Volunteer, Missouri Botanical Gardens City Gardens Tour; Member, Lafayette Square Community Garden Task Force.

2006 Judge, GSA 13th Annual Graduate Research Day Symposium (Saint Louis University); Co-Leader, Lafayette Square Community Garden; Judge, AOA Symposium, SLU School of Medicine; Participant, Habit for Humanity house building (Aug. 5, 2006)

2007 Judge and Organizer, SLU Chapter, Sigma Xi GSA 14th Annual Graduate Research Day Symposium (Saint Louis University, March, 2007); Co-Leader, Lafayette Square Community Garden; Team Captain, SLUVision Express, Foundation Fighting Blindness VISIONWalk (St. Louis, MO, Sept. 29, 2007);

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Board of Directors, Saint Louis Chapter, Foundation Fighting Blindness 2008 Judge, SLU Chapter, Sigma Xi GSA 15th Annual Graduate Research Day

Symposium (Saint Louis University, March, 2008); Co-Leader, Lafayette Square Community Garden; Board of Directors, Saint Louis Chapter, Foundation Fighting Blindness. Organizer and Lecturer, Elsevier Author Workshop, 2008 ICER (Beijing, China; Sept., 2008)

2010- Member, Board of Directors, Buffalo Eye Bank Foundation, Inc.; Vice-President (2011-14)

2012 Judge, Sigma Xi Poster Presentations (Apr. 5), University at Buffalo; Medical Co-Chair, Foundation Fighting Blindness (FFB) Inaugural Western NY VisionWalk (May 20); Team Captain, Ross Eye Institute Rollers, FFB VisionWalk; Member, Buffalo Eye Bank Foundation.

2013 Medical Co-Chair, Foundation Fighting Blindness (FFB) Western NY VisionWalk (May 19); Team Captain, Ross Eye Institute Rollers, FFB Western NY VisionWalk; Judge, UB Postdoctoral Research Day; Member/Vice-President, Buffalo Eye Bank Foundation.

2014 Member, Ross Eye Institute Illuminators, FFB Western NY VisionWalk; Judge, UB 6th Annual Postdoc Research Symposium; Judge, Sigma Xi, UB Graduate Research Day; Vice-President, Buffalo Eye Bank Foundation.

2015 Member, Ross Eye Institute Illuminators, FFB Western NY VisionWalk; Judge, Neuroscience Research Day posters (UB).; Co-Organizer/Moderator, 7th Annual Meeting, SUNY Eye Institute.

2016 Member, Ross Eye Institute Illuminators, FFB Western NY VisionWalk (May 14, 2016); Judge, Neuroscience Research Day (Oct. 7, 2016)

2017 Member and Team Captain, Ross Eye Institute Illuminators, FFB Western NY VisionWalk; Medical Co-Chair, FFB Western NY VisionWalk; Participant, Buffalo March for Science

2018 Member and Team Captain, Ross Eye Institute Illuminators, FFB Western NY VisionWalk; Medical Chair, FFB Western NY VisionWalk;

SUNY-Wide SERVICE: 2010-present Member, Steering Committee, SUNY Eye Institute (SEI) 2013-present Member, Executive Committee (Treasurer), SUNY Eye Institute; 2016- 2018 Member, SUNY Faculty Senate Programs & Awards Committee; MEDICAL SCHOOL/UNIVERSITY SERVICE: 1. University at Buffalo 2008-09 Member, Standing Committee for Facilities Planning and Budget (SMBS)

Member, Search Committee, Director of the Center for Basic Research, Hunter James Kelly Research Institute (Hunter’s Hope); Founding Coordinator (2009-present), Ross Eye Institute Distinguished Lecturers in Vision Science series

2010 Member, Search Committee, Director of the Center for Basic Research, Hunter James

Kelly Research Institute (Hunter’s Hope); Co-Organizer and Session Moderator, “21st Century Bioscience: In Silico Methods and High-Throughput Screening.” Hauptman-Woodward Medical Research Institute, Buffalo, NY (Sept. 11, 2010); Member, Search Committee, Neurology Dept. Chair; Member/Co-PI, CTSA group (Buffalo Translational Research Consortium; Key Function Director, Pilot Clinical and Translational Studies Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, Facilities and Space Committee (SMBS);

2011 Member, Search Committee, Neurology Dept. Chair; Member/Co-PI, CTSA group

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(Buffalo Translational Research Consortium; Key Function Co-Director, Pilot Clinical and Translational Studies Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, Authorship Dispute Panel (Office of the Vice-President for Research); Member, Facilities & Space Committee (SMBS); Member, Core Research Facilities Committee (SMBS);

2012 Member/Co-I, CTSA group (Buffalo Translational Research Consortium; Key Function Co-Director, Pilot Clinical and Translational Studies Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, Facilities & Space Committee (SMBS); Member, Core Research Facilities Committee (SMBS); Member, Promotions Committee, Unqualified (Tenurial) Ranks (SMBS); Clinical Forum Committee; Founding Coordinator (2012-present), Pioneers in Neuroscience Lecture Series.

2013 Member/Co-I, CTSA group (Buffalo Translational Research Consortium; Key Function

Co-Director, Translational Pilot Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, Promotions Committee, Unqualified (Tenurial) Ranks (SMBS); Clinical Forum Committee; Program Co-Organizer and Moderator, SUNY Conversations in the Disciplines Workshop on Creativity and Innovation (Buffalo, NY, June, 2013).

2014 Member/Co-I, CTSA group (Buffalo Translational Research Consortium; Key Function

Co-Director, Translational Pilot Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Promotions Committee, Unqualified (Tenurial) Ranks (SMBS); Member, Biochemistry Chair Search Committee; Organizer/Moderator, Cross-Disciplines Seminar Series; Alternate, SMBS Faculty Council.

2015 Member/Co-I, CTSA group (Buffalo Translational Research Consortium; Key Function

Co-Director, Translational Pilot Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, Promotions Committee, Unqualified (Tenurial) Ranks (SMBS); Member, Biochemistry Chair Search Committee; Organizer/Moderator, Cross-Disciplines Seminar Series; Alternate, SMBS Faculty Council; Member, Dept. of Pediatrics, Strategic Planning Committee- Research Funding Growth; Member, UB Internal Awards Committee

2016 Member/Co-I, CTSA group (Buffalo Translational Research Consortium; Key Function

Co-Director, Translational Pilot Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, UB Internal Awards Committee

2017 Member/Co-I, CTSA Steering Committee (Buffalo Translational Research Consortium);

Key Function Co-Director, Translational Pilot Program; Co-Chair, Pilot Studies Oversight Committee (PSOC)); Member, President’s Review Board (PRB); Member, CTSA-VA Coordination Discussion Group; Member, UB Internal Awards Committee; Faculty Mentor (multiple faculty), JSMBS; Member, Ad hoc VPRED Panel; Poster Judge, 10th Annual Neuroscience Research Day (Oct. 13, 2017); Co-Moderator, Annual Pilot Studies Colloquium (Oct. 12, 2017).

2018 Member/Co-I, CTSA Steering Committee (Buffalo Translational Research Consortium);

Key Function Co-Director, Translational Pilot Program; Co-Chair, Pilot Studies Executive Committee; Member, President’s Review Board (PRB); Member, CTSA-VA Coordination Discussion Group; Member, UB Internal Awards Committee; Faculty Mentor (multiple faculty), JSMBS; Co-Moderator, Annual Pilot Studies Colloquium (Oct. 19, 2018).

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2019 Member, President’s Review Board (PRB); Member, CTSA-VA Coordination Discussion Group; Member, UB Internal Awards Committee; Faculty Mentor (multiple faculty), JSMBS

Buffalo VA Medical Center (VAWNYHS) 2008 Member, Subcommittee on Research Safety (SRS) 2009 Laboratory Safety Officer (LSO); Member, Subcommittee on Research Safety (SRS);

Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC); Acting ACOS/R&D (07/01/09-03/24/10)

2010 Laboratory Safety Officer (LSO); Member, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Laboratory Safety Committee (LSC); Member, Proposal Review Committee (PRC)

2011 Laboratory Safety Officer (LSO); Member, Subcommittee on Research Safety (SRS)- Chair (09/11- present); Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC); Member, Proposal Review Committee (PRC)

2012 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC); Member, Proposal Review Committee (PRC)

2013 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Laboratory Safety Committee (RLSC); Member, Proposal Review Committee (PRC); member, Emergency Management Committee; Chair, ACOS/R&D Search Committee

2014 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC); Member, Proposal Review Committee (PRC); Member, Emergency Management Committee; Acting ACOS/R&D (12/30/13- 06/20/14)

2015 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC); Member, Emergency Management Committee

2016 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Laboratory Safety Committee (LSC); Member, Emergency Management Committee

2017 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC); Member, Emergency Management Committee

2018 Laboratory Safety Officer (LSO); Chair, Subcommittee on Research Safety (SRS); Member, Research & Development Committee (RDC); Chair, Research Laboratory Safety Committee (RLSC)

2. Saint Louis University

1988-89 1988-89 Member, Dean's Task Force, Program Review, Biomedical Communications Division 1988-89 Chairperson, Subcommittee on Facilities and Personnel, Dean's Task Force on

Biomedical Communications, School of Medicine 1989-94 1989-94 Member, Library Committee, School of Medicine 1990-94 1990-94 Chairperson, Biomedical Communications Advisory Committee 1991-92 1991-92 Chairperson, Search Committee, Director of Biomedical Communications Division 1992-94 1992-94 Member, Animal Care Committee, School of Medicine 1992 1992 Member, Dean's Committee on Scientific Misconduct, School of Medicine 1994 1994 Member, Search Committee, Department of Surgery Chair, School of Medicine 1996-97 1996-97 Member, Curriculum Renewal Steering Committee (“Phase 3"), School of Medicine

Alternate Member, Mission and Identity Task Force, Saint Louis University

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Five-Year Program Review Committee, Dept. of Molecular Microbiology & Immunology (Subcommittee: Faculty/Research and Facilities), School of Medicine

1998 Member, Coordinating Committee, Basic Science Correlation Course, School of Medicine

1998-99 Member, Steering Committee, Cell and Molecular Biology (CMB) Graduate Program 1999 Assistant Director, Cell & Molecular Biology (CMB) Graduate Program 1999- Coordinator, Monsanto Visiting Professor Lectureship Series, Cell & Molecule Biology

(CMB) Graduate Program (Monsanto/Pharmacia Lectureship Series, as of 09/2000, for the Graduate Programs in the Biomedical Sciences)

2000- Member, Rules Committee, Faculty Assembly, School of Medicine Member, Executive Committee, Faculty Assembly, School of Medicine Member, Research Planning Committee (RPC), School of Medicine Member, Phase III Curriculum Management Committee (CMC), School of Medicine Member, M.D. Program Self-Study Committee- Graduate Education in Basic

Sciences/Research Member, Library Advisory Committee, SLU Health Sciences Center 2001- Representative for the Graduate School, Ph.D. Dissertation Defense (Craig Paterson,

Center for Health Care Ethics; April 17, 2001) Representative, Executive Committee of the Faculty Assembly, School of Medicine

Member, Committee for Student Academic Appeals (CSAA), School of Medicine (July, 2001-)

2002 Representative (Basic Science Faculty), Faculty Affairs Committee (July, 2002 - ) Representative, Executive Committee of the Faculty Assembly, School of Medicine

2003- Chair, Committee on Student Progress & Program Planning (CSPPP), School of Medicine (2003-2006); School of Medicine Representative to the University Rank and Tenure Committee (2003-2006)

2004-05 Member-at-Large (2-yr term, Elected), Executive Committee of the Faculty Senate, Saint Louis University; Member, Clerkship Review Team (Community & Family Medicine), Phase III Curriculum Committee; Member (2-yr term, Elected) Executive Committee of the Faculty, School of Medicine

2006 Re-elected (2-yr term), Member-at-Large, Executive Committee of the Faculty Senate; Re-elected (2-yr term), Faculty Affairs Committee, School of Medicine.

3. University of Miami School of Medicine

1986-88 1986-88 Member, Admissions Committee, School of Medicine DEPARTMENTAL SERVICE: 1. University at Buffalo (SUNY)

A. Department of Ophthalmology 2008-present Vice-Chair and Director of Research; 2009- Member, Resident Selection Committee (2009, 2011, 2015, 2016) 2009- Participant, Faculty Recruitment 2009-16 Departmental RPB grant application submission and annual renewals 2010- Annual Faculty Performance Review 2010- Founder/Coordinator, Distinguished Lectures in Vision Science series 2011- Founder/Coordinator, Pioneers in Neuroscience lecture series 2012- Chair, Departmental Promotions and Tenure Committee B. Other Departments (secondary appointment) 2009-present PhD Candidacy Exam and Thesis Committees, Dept. of Biochemistry 2009-present PhD Candidacy Exam and Thesis Committees, Neuroscience Program 2. Saint Louis University, School of Medicine

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A. Department of Ophthalmology

1988-2008 Co-organizer, Visiting Professor Research Seminar Series 1988-89 1988-91 Member, Faculty Search Committee

1988-92 Member, Ophthalmology Resident Selection Committee 1989-91 1989-91 Member, Grant Review Committee 1989-93 1989-93 Chair, Promotions & Tenure Committee 1989-93 1989-93 Member, Research Committee 1989-93 1989-93 Member, Academic Committee

1989 Coordinator, BRSG Program Review Committee 1993 1993 Glaucoma Faculty Search Committee 1993 1993 Retina Faculty Search Committee 1994 1994 Co-organizer, Annual Meeting, Anheuser-Busch Eye Institute 1995 1995 Chairperson, Space Allocation Committee

1996 Member, Retina Faculty Search Committee; Member, Committee on Adjunct Faculty Appointments/Promotions; Liaison to Library Committee

1997-98 Liaison, Departmental webmaster 1997- Chairperson, Research Faculty Search Committee 1999 Co-Chair, Promotions and Tenure Committee 2000 -08 Chair, Promotions and Tenure Committee 2001 -08 Director of Research

B. Other Departments (secondary appointment) 1988-89 1988-91 Member, Faculty Search Committees, Dept. of Biochemistry and Molecular Biology

COURSES TAUGHT AND OTHER EDUCATIONAL ACTIVITIES: 1. University at Buffalo/SUNY (2009- present) Ophthalmology Residency Training Program: lectures on how to write a scientific manuscript

for publication; authorship ethics; and scientific misconduct (Feb. 2009; Oct. & Nov. 2010) Ophthalmology Residency Training Program: journal club (March 2009) Ophthalmology Residency Training Program: introduction to research (annually, July; 2009- ) Dept. of Pharmacology & Toxicology: lectures on scientific misconduct and authorship ethics

(April 2009) Dept. of Pediatrics/Fellowship Training Program: lectures on how to write a scientific manuscript

for publication; authorship ethics; and scientific misconduct (April, June 2009; Nov. 2010; April 2011)

Postdoc Survival Skills lectures (lectures on how to write a scientific manuscript for publication; authorship ethics; and scientific misconduct: Sept & Oct. 2010)

BMS 501 (Cell Biology), Interdisciplinary Graduate Training Program: lectures/conference on biological membranes, membrane lipids and proteins (annually, Sept.; 2009- present)

CLIMB Program, UB SMBS: lectures on scientific misconduct and authorship ethics (Feb. 2013; Oct. 2014; 2017; 2018; 2019)

Dept. of Internal Medicine; Residency Training Program: lectures on authorship ethics and scientific misconduct (Feb. 2019)

UB Clinical/Research Ethics Seminar Series, Buffalo CTRC: lecture on scientific misconduct (Feb. 2013); lecture on plagiarism (Feb. 2014)

Program Co-Organizer and Moderator, SUNY Conversations in the Disciplines Workshop on Creativity and Innovation (Buffalo, NY, June 2013).

Dept. of Biochemistry, UB-SMBS, BCH 401 (Undergraduate- Intro to Research): lecture on my own research (Dec. 2012; Oct. 2014; Dec. 2016)

Program Organizer and Lecturer, CTSA Core Competencies Workshop: “Responsible Conduct in Research” (Spring, 2017), including 2 lectures and leading discussion groups

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2. Saint Louis University / School of Medicine (1988-2008) Lecturer, Ophthalmology Grand Rounds, Bethesda Eye Institute: "Hypoxanthine as an Indicator

of Hypoxia in Respiratory Distress Syndrome - Correlates with Purine Metabolism," (April, 1988)

Lecturer, Annual Residents Day Program, Bethesda Eye Institute: "Experimental Retinal Degeneration and Dysplasia," (June, 1988)

Lecturer, Ophthalmology Residents Lecture Series: "Ocular Biochemistry (I & II)," (September, 1988; July, 1989)

Course Co-organizer, "Advanced Topics in Biochemistry," E. A. Doisy Dept. of Biochemistry and Molecular Biology, (Spring, 1989)

Lecturer, Biochemistry Faculty Colloquium Series, E.A. Doisy Dept. of Biochemistry and Molecular Biology: "Membrane Assembly in the Retinal Rod Cell: Now and Zen," (Spring, 1989)

Lecturer, Annual Residents Day Program, Bethesda Eye Institute: "Photoreceptor Membrane Assembly" (July, 1989)

Lecturer, Ophthalmology Clinical Correlations, Dept. of Ophthalmology: "Diabetic Retinopathy: Biochemical Correlates and Treatments," (August, 1989)

Lecturer, Ophthalmology Residents Lecture Series: "Lens Biochemistry," (January, 1990) Lecturer, Medical Biochemistry 511, E.A. Doisy Dept. of Biochemistry and Molecular Biology:

"Biological Membranes: Structure and Assembly," and "Biological Membranes: Transport Processes," (January, 1990; November, 1990, 1991)

Lecturer, E.A. Doisy Dept. of Biochemistry and Molecular Biology, Biochemistry 503 (Graduate Level): Lipid Metabolism (6 lectures), (February, 1990; 1991, 1992)

Lecturer, Ophthalmology Residents Lecture Series: "Photoreceptor Membrane Renewal and Visual Transduction," (April, 1990; July, 1991; July, 1992)

Lecturer, E.A. Doisy Dept. of Biochemistry and Molecular Biology Colloquium Series: "Things My Mother Never Told Me About Lipid and Protein Transport," (Spring, 1990)

Lecturer, Annual Meeting, Bethesda Eye Institute: "Human Photoreceptor Degeneration: Lessons from Basic Experiments with Animal Models," (June, 1990)

Lecturer, E.A. Doisy Dept. of Biochemistry and Molecular Biology, Biochemistry 624: "Advanced Topics in Biochemistry," (February 1991)

Lecturer, Annual Meeting, Bethesda Eye Institute: "Intracellular Trafficking in the Rod Photoreceptor Cell: A Meaningful Mingling of Molecules." (June, 1991)

Lecturer, Annual Meeting, Bethesda Eye Institute: "Lovastatin-Induced Retinal Degeneration." (June, 1992)

Lecturer, Ophthalmology Resident Basic Sciences Lecture Series (Fall, 1993-2008) Lecturer, Program in Cell and Molecular Biology (CMB 510 - Cell Structure, Function &

Regulation); Lectures on Membrane Structure and Function (Spring, 1994-2000) Group Discussion Leader, "Ethics for Research Scientists" (Spring, 1994-2005) Lecturer, Annual Meeting, Anheuser-Busch Eye Institute: "Differential Effects of Inhibitors

Isoprenoid Metabolism on Retinal Structure and Function." (June, 1994) Course Director and Group Discussion Leader, “Ethics for Research Scientists” (Spring, 1998-

2005; designated “BBSG 510" as of Winter, 1999 semester) Lecturer, Ophthalmology Grand Rounds, Saint Louis University Eye Institute (May & Dec. 1997) Lecturer, Basic Biomedical Science graduate course (BBS 501 & 503), lectures on membrane

structure and function, biophysical methods (Fall, 1998- 2008) Course Co-Director, Basic Science Clinical Correlations course, MS-III (“Phase 3") curriculum

(1998-2005) Lecturer, “Super Rounds”, Dept. of Ophthalmology: "A funny thing happened on my way down

the cholesterol pathway." (April, 1999) Lecturer, Basic Science Clinical Correlations course, MS-III (“Phase 3"): “Smith-Lemli-Opitz

Syndrome: Experimental Animal Correlations to Human Disease” (May, 1999) Course Director, Basic Science Clinical Correlations course, MS-III (“Phase 3") curriculum (2000

- 2005)

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Lecturer, Grand Rounds, Dept. of Ophthalmology, “Molecular Biology of Stargardt’s Disease (May, 2000)

Lecturer, Ophthalmology Grand Rounds (Sept. 27, 2000): “Molecular Biology and Biochemistry of Color Vision” (part of case presentation: “Difficulty to Distinguish Colors”; Peng Chen, MD; Steven J. Fliesler, PhD; Gina Kidd, MD)

Lecturer, Ophthalmology “Super Grand Rounds” (Sept. 4, 2002): “Cholesterol Metabolism and Retinal Degeneration: Biochemical, Histological, and Functional Correlates in Rodent Models of Human Disease”.

Group facilitator, BBSG-502 (Special Topics), Nov. 26 and Dec. 3, 2002. Section Director (Membrane Section), BBSG-503, lecturer, BBSG-503 (2003- 2008). Course Director, BBSG-510 (Ethics for Research Scientists; now called Responsible Conduct in

Research); lecturer, BBSG-510 (2003 – 2007): “Ethical Issues in Authorship” and “Dealing with Scientific Misconduct”).

Lecturer, Academic Capstone Course, Phase 3 Curriculum, School of Medicine (Spring, 2005-2008): “Ethical Issues in Authorship;” “Dealing with Scientific Misconduct;” and “How to Publish a Scientific Paper.”

2. University of Miami School of Medicine (1985-1988) Instructor, Endocrine Module (discussion group), Freshman Medical Curriculum (Spring, 1985) Instructor, Cellular and Molecular Biology Course (discussion group), Freshman Medical

Curriculum (Fall, 1985) Lecturer, Ophthalmology Residents and Fellows Lecture Series: "Ocular Biochemistry,"

(Fall,1985) Lecturer, Basic Science Seminar Series: "Protein Glycosylation and Plasma Membrane

Assembly - The Rod Photoreceptor Cell as a Model System," Dept. of Ophthalmology (Fall, 1985)

Lecturer, Basic Science Seminar Series: "Animal Models of Human Retinal Degenerations," Dept. of Ophthalmology (Fall, 1985)

Instructor and Course Organizer, Biochemistry 610: "Biochemistry of Biological Membranes," (Spring, 1986)

Instructor, Endocrine Module (discussion group), Freshman Medical Curriculum (Spring, 1986) Retinitis Pigmentosa Center Journal Club, Dept. of Ophthalmology: "Hyperlipidemia and RP,"

(Spring, 1986) Lecturer, Ophthalmology Residents and Fellows Lecture Series, Dept. of Ophthalmology:

"Ocular Biochemistry (Parts I & II)," (Fall, 1986) Lecturer, Basic Science Seminar Series, Dept. of Ophthalmology: "Experimental Retinal

Dysplasia," (Fall, 1986) Instructor, Cellular and Molecular Biology Course (discussion group), Freshman Medical

Curriculum, (Fall, 1986) Retinitis Pigmentosa Center Journal Club, Dept. of Ophthalmology: "Biochemical Basis of

Gyrate Atrophy," (Fall, 1986) Retinitis Pigmentosa Center Journal Club, Dept. of Ophthalmology: "Leber's Congenital

Amaurosis - Histopathology and Experimental Studies," (Fall, 1986) Lecturer, Advanced Topics in Biochemistry (Biochemistry 610), Dept. of Biochemistry and

Molecular Biology, "Biosynthesis of N-Linked Glycoproteins," (Spring, 1987) Lecturer, Basic Science Seminar Series, Dept. of Ophthalmology: "Differential Transport of

Lipids and Proteins to the ROS," (Spring, 1987) Instructor, Endocrine Module (discussion group), Freshman Medical Curriculum (Spring, 1987) Lecturer, Ophthalmology Grand Rounds, Bascom Palmer Eye Institute: "X-Linked Retinitis

Pigmentosa: Morphological Correlates," (February, 1988) 3. Baylor College of Medicine (1981-1984)

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Instructor, Advanced Topics in Neurosciences: "Biological Membranes: Structure and Function," (Spring, 1981)

Instructor, Advanced Topics in Neurosciences: "Structure and Function of Excitable Membranes," (Spring, 1982)

Lecturer, Neurosciences Seminar Series: "Role of Protein Glycosylation in Retinal Photoreceptor Membrane Morphogenesis," (Fall, 1984)

4. Rice University (1975-1976) Graduate Teaching Assistant, General Biochemistry (1975-76) RESEARCH MENTORING ACTIVITIES:

1. Undergraduate/Graduate / Medical Student Research Rotations & Mentoring

A. University at Buffalo/SUNY, School of Medicine & Biomedical Sciences Matthew Behringer (Fall 2011- May 2012): Undergraduate BCH 504 research elective Cameron Davis (Fall 2012): Undergraduate BCH 504 research elective Sriganesh Ramachandra Rao, B.E, M.S (2013) Graduate Student research rotation Akinsola Oyelakin (Fall 2014 – May 2015): Academic Advisor, CLIMB-Hi Program Jessie Polanco Garcia (Fall 2014 – May 2015): Academic Advisor, CLIMB-Hi Program Aryn Rowsam (Summer, 2015- May, 2016): Undergraduate BCH 504 research elective Steven Lewis (Fall 2016 – ): Academic Advisor, CLIMB-Hi Program Joseph Lucas (Fall 2017 – ): Academic Advisor, CLIMB-Hi Program Hannah Bogart (Winter/Spring 2017): Undergraduate BCH 504 research elective Andrulisa Jones (Winter/Spring 2017): Undergraduate BCH 504 research elective Jordan Thompson (Master’s Program, Neuroscience; 2018- present) John Petrie (M.D. student, 2019- present)

B. Saint Louis University / School of Medicine

Rita Heuertz (1989; Program in Cell and Molecular Biology) Timothy Cornell (1989; Program in Cell and Molecular Biology) Peter C. Pauly (1990; Dept. of Biochemistry and Molecular Biology) Rob Mullins (1992; Program in Cell and Molecular Biology) Brett Foersterling (1993; MS-II Medical Student Research Elective) Markus Kuehn (1994; Program in Cell and Molecular Biology)

Sok Nam (1994; MS-II Medical Student Research Elective) Gary Gray (1996; Summer MS-II Medical Student Research Elective) David Bryant (1997; MS-III Medical Student Research Elective) Devin Waldrop (1999; Summer MS-II Student Research Elective) Christopher Singh (2000; Summer MS-II Student Research Elective) Andrew Yen (2000; Summer MS-II Student Research Elective) Eric Knoll (Spring, 2001; CORE Graduate Program in Biomedical Sciences) Lauren Handley (Spring, 2002; CORE Graduate Program in Biomedical Sciences) James Taylor (Spring, 2003; CORE Graduate Program in Biomedical Sciences) Darcy Denner (Spring, 2007; CORE Graduate Program in Biomedical Sciences) Marius Busauskas (Spring, 2008; CORE Graduate Program in Biomedical Sciences) 2. Thesis / Dissertation and Candidacy Exam Committees

B. University at Buffalo/SUNY Mary Alice Garlipp (PhD, Neuroscience Program; 2008- 2012) Patrick Itotia (PhD, Neuroscience Program; Prelim Exam; 2008-2009)

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Tiffany Kolniak (PhD, Neuroscience Program; 2008- 2012) Elizabeth Lassman (PhD, Neuroscience Program; 2009-2010) Alan Haungs (MS, Electrical Engineering; 2009-2011) Mariapaola Sidoli (PhD, Dept of Biochemistry; 2011-2015) Kushal Suryamohan (PhD, Dept of Biochemistry; 2012-2016) Will Hsu (PhD, Neuroscience Program; 2013-14) Sriganesh Ramachandra Rao (PhD primary mentor, Dept of Biochemistry, 2013-2018) Maulasri Bhatta (PhD, Neuroscience Program; 2014-17) Adeline Verhoski (PhD, Dept of Biochemistry, 2016-17) Nadav I. Weinstock (PhD, Dept of Biochemistry (MD/PhD Program), 2014-- ) Jordan Thompson (MS, Neuroscience Program; 2019 - )

C. Saint Louis University

Hong-Duck Um (1990; Dept. of Biochemistry and Molecular Biology) Julie Krsek-Staples (1990-1992; Program in Cell and Molecular Biology) Christopher Eddy (1991; Dept. of Biochemistry and Molecular Biology) Lee Cody (1991-1992; Dept. of Biochemistry and Molecular Biology) Peter C. Pauly (1992-1995; Dept. of Biochemistry and Molecular Biology) Sharon Peters (1992; Program in Cell and Molecular Biology) James Powers (1992; Program in Cell and Molecular Biology) Ron Lee (1993 (extra-departmental examiner); Dept. of Biology)

Markus Kuehn (1996-2000 (thesis committee); Program in Cell and Molecular Biology) Kyuhwan Shim (1997 (extra-departmental examiner); Dept. of Biology) Dennis Matlock (2000; Graduate School official representative, thesis defense; Dept. of

Biochemistry & Molecular Biology) Michael Nickells (2000-2001; Program in Cell and Molecular Biology, thesis committee)

Chair, Examination Committee (Michael W. Nickells: Minor Proposal), Program in Cell and Molecular Biology (July 31, 2001)

Angela Hackenwerth (2007-2010; Dept. of Biology, thesis committee) Daniel Rajkumar (Summer, 2007), SLU Summer Research Apprenticeship Program, Office of Multicultural Affairs; Co-mentor, with Dr. Roger Lewis, Sch. of Public Health. Erin Li (Summer, 2007), Pfizer-Solutia STARS (Students and Teachers as Research Scientists) Program.

B. University of Miami, School of Medicine Ruth Batchelder (1987-88; Dept. of Biochemistry and Molecular Biology) Wanping Jiang (1987-88; Dept. of Biochemistry and Molecular Biology) C. External (Outside Examiner) Thesis/Dissertation Committees Kathleen Boesze-Battaglia (1989, Dept. of Biochemistry, State University of New York at

Buffalo, Buffalo, NY) Linda Lininger (1996; Dept. of Biochemistry and Molecular Biology, Wright State

University, Dayton, OH) Rafal Farjo (2006; Dept. of Cell Biology, University of Oklahoma Health Sciences

Center, Oklahoma City, OK) Erik Otter Johnsen (2014; Center for Eye Research, Dept. of Ophthalmology, Oslo

University Hospital and University of Oslo; Oslo, Norway) Damian Dasznski (2016- ; Department of Medicinal Chemistry, University of Nebraska

Medical Center, Omaha, NE) 3. Postgraduate / Senior Scientist / Junior Faculty Mentoring/Supervision

A. University at Buffalo/SUNY

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1. Department of Ophthalmology Lowell G. Sheflin, PhD (2008-2011), Postdoctoral fellow supervisor Bruce A. Pfeffer, PhD (2010- 2016), Sr. Scientist supervisor Christopher Goulah, PhD (2011-2013), Postdoctoral fellow supervisor Xiuqian Mu, MD, PhD (2008–2015), Faculty primary mentor Sangita P. Patel, MD, PhD (2014- ), Faculty primary mentor / KO8 submission Gareth M. Lema, MD, PhD (2014-2016), Faculty primary mentor Nestor Mas Gomez, PhD (2016), ISER Lab Exchange mentor (U. PENN) Michael H. Farkas, PhD (2016- ), Faculty primary mentor Lara A. Skelton, PhD (2016- ), Postdoctoral fellow supervisor Sriganesh Ramachandra Rao, PhD (2018- ), Postdoctoral fellow supervisor 2. Extra-Departmental Faculty Mentoring Committees

Christine Schaner-Tooley, PhD (2017- ), Dept. of Biochemistry, JSMBS Stephanie Anzman-Frasca, PhD (2017- ), Dept. of Pediatrics, JSMBS Matthew J. Barth, MD (2017- ), Dept. of Pediatrics, JSMBS Jayasree Nair, MBBS (MD) (2017- ), Dept. of Pediatrics, JSMBS Laurene M. Tumiel-Berhalter, PhD (2017- ), Dept. of Family Medicine, JSMBS 3. ARVO Global Mentorship Program

Ling Lee, BOptom, PGCertOcThera (U. New South Wales and the Brien Holden Vision Institute, Sydney, Australia; 2016) G. Alex Ochakovski, MD (University Eye Hospital, Tuebingen, Germany; 2018) Yang Zhang (MD student, Creighton U., Omaha, Nebraska; 2019)

B. Saint Louis University, School of Medicine Hirohumi Arakawa, Ph.D. (1988-89; Dept. of Ophthalmology) Prasoon Chaturvedi, Ph.D. (1990; Dept. of Ophthalmology) David Saperstein, M.D. (1992-93; Dept. of Ophthalmology) K. George Thampy, Ph.D. (1993; Dept. of Ophthalmology) Vidudala V.T.S. Prasad, Ph.D. (1993-1994; Dept. of Ophthalmology)

C. University of Miami, School of Medicine Ignacio R. Rodriguez, Ph.D. (1985-87; Dept. of Ophthalmology) GRANT SUPPORT:

1. Active (Current) Grant Support 1 R01 EY029341-01 “Development and Characterization of Mouse Models of RP59 DHDDS Deficiency” National Eye Institute/NIH Multi-PD/PI: Steven J. Pittler, PhD (UAB) and Steven J. Fliesler, PhD (UB; 15%) Total costs: $2,208,923 [07/02/18-06/30/22] 2 I01 BX002439-04A1 VA MERIT Award (competing renewal of 1 I01 BX002439-01A1 “Ocular Sequelae and Intervention in a Rat Model of Blast Overpressure Polytrauma”); Multi-PD/PI: Steven J. Fliesler, PhD (Buffalo VAMC); and Machelle T. Pardue, PhD (Atlanta VAMC). *Scored (1.1%)-[01/01/19 - 12/31/22]

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2 R01 EY019949-07 “ER Stress and Diabetic Retinopathy” National Eye Institute/NIH Principal Investigator: Sarah X. Zhang, MD (Co-I: Steven J. Fliesler, PhD) Total costs: $1,590,636 [09/01/15 - 08/31/19]

1R01 EY027476-01 “Rapalogue Therapy in Heritable and Vigabatrin-Induced GABA Metabolic Disorders” National Eye Institute/NIH Principal Investigator: K. Michael Gibson, PhD (Consultant/Collaborator: Steven J. Fliesler, PhD) Total costs: $1,581,766 [UB Subaward (SJF): $56,827] [05/01/17 – 04/30/21] IBX004557A VA-ORD (competing renewal of “Deciphering Genetic and Environmental Influences on Visual Disorders in the Million Veteran Program”)- PI: Neal S. Peachey, PhD (Louis Stokes Cleveland VAMC); Steven J. Fliesler, PhD (Co-I; 5%; Buffalo VAMC) [04/01/19 - 03/31/23]

2. Pending (Submitted) / Planned Grant Applications 1 UL1 TR001412-05 “Buffalo Clinical and Translational Research Center”; NCATS, National Institutes of Health (Clinical and Translational Science Award). Principle Investigator: Timothy F. Murphy, MD (Co-I: Steven J. Fliesler, PhD; 15%; Co-Director, Pilot Studies, Research Implementation and Participation (RIP) Core Total costs: $22,698,278 [04/01/19 – 03/31/24] [Not funded; resubmitted March, 2019] 3. Prior (Completed) Grant Support 1 UL1 TR001412-01 “Buffalo Clinical and Translational Research Center” NCATS, National Institutes of Health (Clinical and Translational Science Award) Principle Investigator: Timothy F. Murphy, MD (Co-I: Steven J. Fliesler, PhD; Co-Director, Pilot Studies, Research Implementation and Participation (RIP) Core Total costs: $14,141,685 [08/12/15 – 03/31/19] 1 I01 BX002439-01A1 “Ocular Sequelae and Intervention in a Rat Model of Blast Overpressure Polytrauma” Department of Veterans Affairs BLR&D MERIT REVIEW Award for Traumatic Brain Injury (TBI) Principal Investigator: Steven J. Fliesler, PhD Total costs: $499,998 (01/01/15 – 12/31/18) 2 RO1 EY007361-24 "Isoprenoid Metabolism in the Retina" National Eye Institute (NEI/NIH) Principal Investigator: Steven J. Fliesler, Ph.D. Total costs: $1,955,213 (01/01/2012 – 12/31/2015; No-cost extension through 12/31/16)

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“Membrane-Permeable Transcriptional Regulators for Retinal Repair” RF/SUNY Brain Network of Excellence Principal Investigator: Michael E. Zuber [Steven J. Fliesler, Co-I] Total costs: $93,675; 2014-15 (No-cost extension through 2016) 1 I01 BX003364-01 “Genetic Risk for AMD in Diverse Veteran Populations” Department of Veterans Affairs: Special Initiatives- MVP Projects Principal Investigator(s): Eric P. Konicki, M.D., Neal S. Peachey, Ph.D.

(Co-I: Steven J. Fliesler, PhD) Total costs: $126,619 [04/01/16-09/30/16] 1RO1 EY019494-01A1 “Role of Caveolin-1 in the Maintenance of Blood-Retinal Barrier Integrity” National Institutes of Health (NEI/NIH) Principal Investigator: Michael H. Elliott, PhD [Steven J. Fliesler, Subcontract] Total Subcontract costs: $94,500; 11/01/09– 11/30/14 “Function of Onecut Transcription Factors in Retinal Development and Vision” RF/SUNY Research Collaboration Fund Principal Investigator: Xiuqian Mu [Steven J. Fliesler, Co-I] Total project costs: $100,000, 2012-14 “The Role of Phospholipid Transfer Protein (PLTP) in Lipoprotein Metabolism in the Retina” SUNY Eye Institute Pilot Grant Program Co-PIs: William R. Brunken (SUNY Downstate Med Ctr) & Steven J. Fliesler (SUNY-Buffalo) Total project costs: $20,000, 2013-14 "Isoprenoid Metabolism in the Retina" National Eye Institute (NEI/NIH), 2RO1 EY007361 Principal Investigator: Steven J. Fliesler, Ph.D. Jan. 1, 2007 – Dec. 31, 2010 (no-cost extension to Dec. 31, 2011) Total costs: $1,466,310 (TDC: $1,000,000) Transferred to UB/SUNY 09/01/08- 12/31/08 (Total: $226,381) 2RO1 EY007361-17 (01/01/09-12/31/09) TDC: $250,000; Total: $311,803 2RO1 EY007361-18 (01/01/10-12/31/11) TDC: $247,500; Total: $305,415 VA Central Office Equipment Grant (May, 2011) $128,960 for Leica laser confocal microscope ($151,178 with match from UB sources) $115,456 for Biotigen OCT ($136,942 with match from UB sources) “Proteasome Function in the Aging Retina” National Institutes of Health (NEI/NIH) 1RO1 EY013623-A2 10/01/09 – 09/30/11 Principal Investigator: Deborah A. Ferrington, PhD (Univ. of Minnesota) SJ Fliesler, Subcontract. Total costs: $15,832 ARRA FUNDING “Evaluation of Efficacy of 8-OH-DPAT, a 5-HT1A Receptor Agonist with Regard to Protection Against Retinal Degeneration and Dysfunction in the AY9944-induced Rat Model of Smith-Lemli-Opitz Syndrome (SLOS)” Alcon Research Laboratories Principal Investigator: Steven J. Fliesler, PhD March-Dec., 2010 Total costs: $31,500

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“Apolipoprotein Isoforms and Retinal Degeneration” *PRIORITY SCORE: 160 National Institutes of Health (NEI/NIH) 1 R21 EY017019 Principal Investigator: Steven J. Fliesler, Ph.D. Feb. 1, 2006 – Jan. 31, 2008 Total costs: $366,332 (01: $183,750; 02: $182,582; TDC: $249,199) Research to Prevent Blindness Senior Scientific Investigator Award Jan., 2007- July, 2008 $75,000 "Isoprenoid Metabolism in the Retina" National Eye Institute (NEI/NIH), 2RO1 EY007361-10A2 Principal Investigator: Steven J. Fliesler, Ph.D. April 1, 2001 - March 31, 2005 [No-cost extension through Dec. 31, 2006] Total costs: $1.18 million Supplement Award No. 3 R01 EY007361-13S1 "Isoprenoid Metabolism in the Retina" National Eye Institute (NEI/NIH), 2RO1 EY07361-10A2 Principal Investigator: Steven J. Fliesler, Ph.D. April 1, 2004 – March 31, 2005 Total costs: $73,500 "Isoprenoid Metabolism in the Retina" National Eye Institute (NEI/NIH), RO1 EY07361 Principal Investigator: R. Kennedy Keller, Ph.D. Co-Principal Investigator: Steven J. Fliesler, Ph.D. Mar. 1, 1988 - Feb. 28, 1991 Total costs: $180,152 July 1, 1991 - June 30, 1994 (renewal) Total costs: $543,717 "Isoprenoid Metabolism in the Retina" National Eye Institute (NEI/NIH), RO1 EY07361 Principal Investigator: Steven J. Fliesler, Ph.D. December 1, 1996 - November 30, 2000 (renewal) Total costs: $0.992 million “Isoprenoid Metabolism in the Retina” National Eye Institute (NEI/NIH), RO1 EY07361 Principal Investigator: Steven J. Fliesler, Ph.D. Supplemental Award October 1, 1997- September 30, 1998 Total costs: $27,920 "Glycoprotein Synthesis and Metabolism in Human and Animal Retinas" National Eye Institute (NEI/NIH), RO1 EY04738 Principal Investigator: Steven J. Fliesler, Ph.D. June 1, 1983 - Dec. 31, 1984 Total costs: $219,450 "Glycoprotein Synthesis and Metabolism in Retinas" National Eye Institute (NEI/NIH), RO1 EY06045 Principal Investigator: Steven J. Fliesler, Ph.D.

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Jan. 1, 1985 - May 31, 1986 (transfer of RO1 EY04738) Total costs: $254,100 Aug. 1, 1986 - July 31, 1989 (renewal) Total costs: $524,398 Aug. 1, 1989 - Nov. 30, 1992 (renewal) Total costs: $773,629 Dec. 1, 1992 - Nov. 30, 1997 (renewal) Total costs: $1.12 million "Retinitis Pigmentosa Center Grant" National RP Foundation Fighting Blindness (Baltimore, MD) Principal Investigator: Samuel G. Jacobson, Ph.D., M.D. Co-Principal Investigator: Steven J. Fliesler, Ph.D. July 1, 1987 - June 30, 1989 Total costs: $357,986 "Core Grant for Vision Research" National Eye Institute (NEI/NIH), EY02180 Principal Investigator: Paul F. Palmberg, Ph.D., M.D. Co-Principal Investigator: Steven J. Fliesler, Ph.D. Mar. 1, 1985 - Feb. 29, 1988 Small Instrumentation Program (SIP) Grant National Institutes of Health (NIH), HL41711 Principal Investigator: William H. Elliott, Ph.D. Co-Principal Investigator: Steven J. Fliesler, Ph.D. June 1, 1988 - May 31, 1989 Total costs: $50,492 Biomedical Research Support (BRSG) Grant National Institutes of Health (NIH), RR07247 Principal Investigator: David J. Schanzlin, M.D. Grant Coordinator: Steven J. Fliesler, Ph.D. April 1, 1989 - Mar. 31, 1990 Total costs: $13,817 Small Instrumentation Program (SIP) Grant National Eye Institute (NEI/NIH), S15 EY08939 Principal Investigator: Steven J. Fliesler, Ph.D. July 16, 1990 - July 15, 1991 Total costs: $5,000 Biomedical Research Support (BRSG) Grant National Institutes of Health (NIH), RR06045 Principal Investigator: Steven J. Fliesler, Ph.D. April 1, 1991 - Sept. 29, 1992 Total costs: $6,143 Small Instrumentation Program (SIP) Grant National Eye Institute (NEI/NIH), S15 EY09995 Principal Investigator: Steven J. Fliesler, Ph.D. July 13, 1992 - July 12, 1993 Total costs: $8,403 Animal Facility Improvement for Small Research Program

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Comparative Medicine Program (NIH), G20 RR07964 Principal Investigator: Steven J. Fliesler, Ph.D. July 1, 1992 - June 30, 1993 Total costs: $205,196 Animal Facility Improvement for Small Research Program Comparative Medicine Program (NIH), G20 RR08588 Principal Investigator: Steven J. Fliesler, Ph.D. May 1, 1993 - April 30, 1994 Total costs: $250,000 Small Instrumentation Program (SIP) Grant National Institutes of Health, S15 EY10352 Principal Investigator: Steven J. Fliesler, Ph.D. July 9, 1993 - July 8, 1994 Total costs: $7,200 Small Instrumentation Program (SIP) Grant National Institutes of Health Principal Investigator: Steven J. Fliesler, Ph.D. July 11, 1994 - July 10, 1995 Total costs: $11,107 “Effects of Vitamin and Sterol Supplementation in a Rodent Model of Smith-Lemli-Opitz Syndrome” March of Dimes, #1-FY01-339 Principal Investigator: Steven J. Fliesler, Ph.D. July 1, 2001 - June 30, 2004 Total costs: $195,927 “Apolipoprotein E and Retinal Degeneration” The Foundation Fighting Blindness, #T-CB-0901-0204 Principal Investigator: Steven J. Fliesler, Ph.D. Sept. 1, 2001 - Aug. 31, 2004 Total costs: $76,760 “Apolipoprotein Isoforms and Retinal Degeneration” National Institutes of Health (NEI/NIH) 1 R21 EY017019 Principal Investigator: Steven J. Fliesler, Ph.D. Feb. 1, 2006 – Jan. 31, 2008 [no-cost extension through June 30, 2009] Total costs: $366,332 (01: $183,750; 02: $182,582; TDC: $249,199) Transferred to UB/SUNY Sept. 01, 2008- Jan. 31, 2009 (Total: $69,195)

4. Submitted/Unfunded Applications “Effect of ApoE Isoform Expression on Retinal Degeneration” Veterans Administration, Merit Award 1IO1BX000237-01A1 Principal Investigator: Steven J. Fliesler, Ph.D. Total costs: $500,000 {not awarded} “Development of Tools for Analysis of Oxidatively Modified Lipids and Proteins” National Institutes of Health (NIH/NIGMS) ARRA Challenge Grant Principal Investigator: Sanjoy Battacharya, PhD (Univ. of Miami) SJ Fliesler, Subcontract. Total costs: $80,000 {not awarded}

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“High-Throughput Lipidomics in Ocular Diseases” National Institutes of Health Principal Investigator: Sanjoy Battacharya, PhD. (U. Miami) (Submitted: March 2010) {not awarded} “Blast Wave Injury to the Auditory System and Retina in a Rodent Model” Veterans Administration (BLR&D MERIT REVIEW) 1 IO1BX001126-01 Principal Investigator: Steven J. Fliesler, PhD (Submitted: Sept. 2010) {not awarded} “Antioxidant-Based Therapeutic Intervention for Blast Overpressure Polytrauma” Veterans Administration (RR&D MERIT REVIEW) 1 I01 RX000774-01 Principal Investigator: Steven J. Fliesler, PhD (Submitted: June 2011; Administratively withdrawn) “SUNY Eye Institute Core for Vision Research” 07/01/13 – 06/30/18 National Eye Institute/National Institutes of Health 1P30 EY021723-A1 Principal Investigator: William J. Brunken, PhD (SUNY Downstate, Brooklyn) SJ Fliesler, Co-Investigator/Module Director (Bioanalytics Module) Total costs: $3,907,995 (TDC: $2,472,520; annual DC, Yr-1: $720,263) [TDC for Bioanalytics Module: $1,195,365] {Submitted (10/12) / Scored/ Not awarded} “Buffalo Clinical and Translational Research Center” 07/01/13 – 06/30/18 National Institutes of Health 1U54 RR032372-01A1 Principal Investigator: Timothy F. Murphy, M.D. S.J. Fliesler, Key Function Director (Novel Methodologies/Pilot Studies) Total costs: $19,918,829 (Annual DC, Yr-1: $2,641,206) {Submitted Jan. 2013; scored/not funded-- revision pending} “Training Program in Neurodegeneration” National Institutes of Health 1 T32 NS086756-01 Principal Investigator: Gabriela Popescu, PhD SJ Fliesler: Co-Investigator Total costs: $1,103,384; (TDC: $1,058,214; DC Yr-1: $193,774) 04/01/14 – 03/31/19 {Submitted (05/13); Not funded-- revision pending} “Mitochondrial dynamics in RPE Homeostasis and Disease” National Eye Institute (NEI/NIH), 1R01EY024944-01 Principal Investigator: Scott Plafker, PhD Total costs: $1,975,000 (10/01/14 – 09/30/19) Submitted Feb. 2014; JIT documents requested, but Not funded “Novel Antioxidant Therapeutic Intervention for Blast Overpressure-Induced Injury” Department of Defense, Vision Research Program Translational Research Award [CDMRP] “Mitigation and Treatment of Traumatic Injuries, War-Related Injuries, and Diseases to Ocular Structures and the Visual System” MR130095 Principal Investigator: Steven J. Fliesler, PhD Total costs: $941,948 Submitted FEB.2014; [Overall Score: 2.0; Notification of intent to fund rec’d, JIT documents requested-- but not funded]