Stephen Allan Schaffer MD FRCPC*

Assistant Professor of Medicine

Max Rady College of Medicine

Faculty of Health Sciences

University of Manitoba

Sections of Cardiology and Critical Care Medicine

Director WRHA Acute Cardiac Care Unit

Director HSC Coronary Care Unit

WRHA Cardiac Transplant and Mechanical Circulatory Support Program

Max Rady College of Medicine, University of Manitoba

Y3012, Bergen Cardiac Care Centre

St. Boniface General Hospital, 409 Tache Avenue

Winnipeg, Manitoba, Canada, R2H 2A6

(204) 235-3995 (Office), (204) 231-3006 (Fax)

aschaffer@sbgh.mb.ca

* Professional Services provided through Medical Corporation

EDUCATION 2010-2012 Post-Doctoral Clinical Fellow: Interdivisional Department of Critical Care Medicine

Program Director: Dr. D. Scales University of Toronto, Toronto General Hospital, University Health Network

2009 – 2010

Post-Doctoral Clinical Fellow: Advanced Heart Failure and Cardiac Transplant Program Director: Dr. Heather Ross

University of Toronto, Toronto General Hospital, University Health Network

2012 Fellow of the Royal College of Physicians and Surgeons of Canada, Critical Care Medicine Candidate number: 639642 2012

2006-2009 Cardiology Fellow University of Manitoba

Fellow of the Royal College of Physicians and Surgeons of Canada, Internal Medicine Candidate number: 639642

2003 American Board Certification, Internal Medicine

2003 - 2006

Internal Medicine Residency University of Manitoba

2007

Licentiate of the Medical Council of Canada Licentiate number: 16-358

1999-2003

Doctor of Medicine University of Manitoba

1999-2003

Bachelor of Science (Medicine) Thesis: Development of DNA based vaccine for Cryptosporidium parvum Supervisors: Dr. L. Babiuk, Vaccine and Infectious Disease organization (VIDO), University of Saskatchewan, and Dr. J.N. Simonsen, Department of Medical Microbiology, University of Manitoba University of Manitoba

1995-1999

Bachelor of Sciences (Honours), First Class Honours, Zoology Thesis: Seroepidemiology of Cryptosporidium parvum in Manitoba Supervisor: Dr. J. N. Simonsen University of Manitoba

DEGREES 2003/5 Doctorate, Doctor of Medicine, Medicine, The University of Manitoba

Degree Status: Completed

- 2003/5 - 2003/4 Bachelor's, Sciences, Medicine, The University of Manitoba

Degree Status: Completed

Thesis Title: Devolpment of DNA based vaccine for Cryptosporidium parvum

Supervisors: Dr. L. Babiuk, Vaccine and Infectious Disease organization (VIDO),

University of Saskatchewan

1999/4 Bachelor's Honours, Science, Zoology, The University of Manitoba

Degree Status: Completed

Thesis Title: Seroepidemiology of Cryptosporidium parvum in Manitoba

Supervisors: Dr. J.N. Simonsen

CREDENTIALS 2017/10 ACLS Recertification

2017/08 BLS Recertification

2012/1 FRCPC Subspecialty (Critical Care Medicine) ID# 639642, Royal College of Physicians and Surgeons of Canada

2010/1 Advanced Trauma Life Support (ATLS) Certification

2009/1 Level 2 certification Echocardiography(Transthoracic/Transesophageal)

2009/1 FRCPC Subspecialty (Cardiology), (ID# 639642), Royal College of Physicians and

Surgeons of Canada 2009/1 Advanced medical/surgical training in HeartMate2 LVAS. Thoratec Corporation, Johns

Hopkins University 2007/1 FRCPC (Internal Medicine), (ID#639642), Royal College of Physicians and Surgeons of

Canada 2006/1 ABIM

2005/1 ACLS Recertification

2004/1 LMCC part 2 (ID# 97366), Medical Council of Canada

2003/1 USMLE step I

2003/1 USMLE Step II

2003/1 ACLS

1998/1 Safe handling and ethical use of animals in experimental research (22.450),

Department of Zoology, The University of Manitoba

ACADEMIC APPOINTMENTS 2012 Assistant Professor, Department of Medicine, Section of Cardiology, University of Manitoba,

Winnipeg, Manitoba, Canada,

2008 - 2009

Chief Resident, Section of Cardiology, University of Manitoba, Winnipeg, Manitoba, Canada

2007- 2008 Associate Chief Resident, Section of Cardiology, University of Manitoba, Winnipeg, Manitoba, Canada,

CLINICAL APPOINTMENTS

2012 Locum Attending Physician, Critical Care Medicine, Health Sciences North/Horizon Santé-Nord, Sudbury, ON

2012-2017 (unit

closure) Attending Physician, Intensive Care Unit, Victoria General Hospital

2017-present Attending Physician, Intensive Care Unit, Grace General Hospital

2012-2018 Attending Physician, Associate Director , Acute Cardiac Care Unit, St. Boniface Hospital

2012-present Attending physician, Heart Failure and Transplant Clinics, Cardiac Sciences Program, WRHA

2012-present Attending Physician, Director, Cardiac Care Unit, Health Sciences Centre

2012-2014 Attending Physician, Intensive Care Cardiac Surgery, St. Boniface Hospital

2015-present Attending physician, Medical Surgical Intensive Care Unit, St. Boniface Hospital

2018-present Attending Physician, Medical Director , Acute Cardiac Care Unit, St. Boniface Hospital

2018-present Attending Physician, Cardiology Physician Lead, Inherited Cardiomyopathy Clinic. St. Boniface Hospital

HONOURS AND AWARDS 2001 The Fillmore Riley Ade & company Award for excellence in Experimental Research

1999 H.E. Welch Award of Excellence in Zoology

EVALUATION OF ARTICLES FOR SCIENTIFIC JOURNALS 2017-present Invited Reviewer- British Medical Journal

2013-present Invited Reviewer – Transplant International

2012-present Invited Reviewer – Pediatric Transplantation

2015 Invited Reviewer: HF Reviewer for the 2015 Canadian Cardiovascular Congress (CCC)

2016 Invited Reviewer: HF Reviewer for the 2016 Canadian Cardiovascular Congress (CCC)

PROFESSIONAL SOCIETIES AND AFFILIATIONS Boards 2012-2017 Canadian Cardiovascular Critical Care Society, Member, Board of Directors 2017-present Canadian Blood Services, Heart Transplant Advisory Board Professional Societies 2012 - present Member of the Canadian Heart Failure Society (CHFS) 2012 - present Member of the Canadian Heart Failure Network (CHFN) 2012 - present Member of the College of Physicians and Surgeons of Manitoba 2012 - present Member of the Canadian Cardiac Transplant Network (CCTN) 2010 - present Member of the Canadian Society of Transplant (CST) 2012 - present Member of the Canadian Cardiac Critical Care Society (CCCS) 2012 - present Member of the International Society Heart and Lung Transplantation (ISHLT) 2007 - present Fellow of the Royal College of Physicians and Surgeons of Canada 2009 - present Member of the Canadian Cardiovascular Society (CCS) 2012 - present Member of the Manitoba Medical Association (Doctor’s Manitoba) 2012 - present Member of the Manitoba Medical Association (Doctor’s Manitoba) 2012 - present Member of the Canadian Medical Association 2009 - 2013 Member of the College of Physicians and Surgeons of Ontario 2009 - 2013 Member of the Ontario Medical Association Committees 2019-present Critical Care Renal Replacement therapy

2018-present Canadian Cardiac Sarcoid advisory committee

2017-present Canadian Blood Services, Heart Transplant Advisory/Organ Allocation Committee

2017-Present St. Boniface Hospital VAP committee

2017-Present St. Boniface Hospital Delirium prevention Committee

2017-Present St. Boniface Hospital, ACCU, Quality Improvement Committee

2013 - present Cardiac Sciences, Cardiology Subspecialty Resident Training Committee, CCU and Heart failure/Transplant rotations

2013 – present St. Boniface Hospital, Intensive Care Medicine Quality Improvement Committee

2007 - 2009 Section of Cardiology, Physician Representative, Physician Design Team, Hospital Information System Project

2006 – 2007 Resident Representative, Cardiology Training Committee

2005 -2006 Resident Representative, WRHA Internal Medicine Medical Standards Committee

2003 - 2006 Resident Representative, Internal Medicine Undergraduate Curriculum Committee

Grants, Contracts and Clinical Trial

Industry Sponsored Clinical Trials

[Local co PI] EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Study sponsor: Boehringer Ingelheim, Eli Lilly

Status: enrolling [Local co PI] DETERMINE-Reduced D169EC00002: An international, multicentre, parallel-group, randomized,

double-blind, placebo-controlled, Phase III study evaluating the effect of Dapagliflozin on exercise capacity in heart failure patients with reduced ejection fraction (HFrEF)

[Local PI] VICTORIA HF Registry: Characterizing patients admitted with heart failure decompensation

Study Sponsor: Merck

Status: enrollment completed

[Local PI] VICTORIA trial: A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001)

Study sponsor: Merck

Status: Enrollment completed, June 2019

[Local PI]

PARTHENON - PAtient RegisTry assessing effectiveness and safety of Heart failure treatmeNt with LCZ696 (sacubitril/valsartan) acrOss CaNada

Study sponsor: Novartis

Status: enrollment completed August 2017

[Co PI]

PARASAIL -Tolerability of LCZ696 (Sacubitril / Valsartan) in Heart Failure With Reduced Ejection Fraction (HFrEF) Treated in Real Life Setting (PARASAIL) PAtient RegisTry assessing effectiveness and safety of Heart failure treatmeNt with LCZ696 (sacubitril/valsartan) acrOss CaNada

Study sponsor: Novartis

Status: Enrollment Completed August 2017

[Co PI] EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Study sponsor: Boehringer Ingelheim, Eli Lilly

Status: Active, Recruitment completed

[Co PI] GALACTIC-HF- Registrational Study With Omecamtiv Mecarbil/AMG 423 to Treat Chronic Heart Failure With Reduced Ejection Fraction

Study sponsor: AMGEN

Status: Active, Recruitment completed

Investigator initiated Trial

[CoPI] CT perfusion (CTP) for Assessment of poor Neurological outcome in Comatose Cardiac Arrest Patients (CANCCAP)-a prospective cohort study.

Study Sponsor: MMSF

PI: Dr. Jai Shankar

Status: Approved, enrollment TBD [Local Co PI] MINT trial : Myocardial Ischemia and Transfusion

Study sponsor: NHLBI, Rutgers, The State University of New Jersey

Status: Recruiting

[Local PI]

SODIUM-HF: Study of Dietary Intervention Under 100 MMOL in Heart Failure (SODIUM-HF)

Study sponsor: CIHR

Status: Recruiting

PI: Justin Ezekowitz

[Local PI] REVAD: Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation]

Study sponsor: [VIGOUR centre]/Pfizer

PI: [Nowell Fine]

Status: Enrolling

[Local co-PI] Global Congestive Heart Failure Registry (G-CHF)

Study sponsor: PIHR, CIHR

PI: Salim Yusuf

Status: Active, not enrolling

[PI]

Tachymyopathy: Study of tachycardia induced cardiomyopathy, retrospective review

Study sponsor: Investigator funded

Status: Data analysis

PI: SA Schaffer

[PI]

Association between non-invasive and invasive blood pressure measurements in patients

with intra-aortic balloon pumps

Study sponsor: Investigator funded

Status: Submitted

PI: SA Schaffer

[Co PI] Multiple Sclerosis-Heart. Cardiac outcomes in MS population

Study sponsor: CIHR/MS Canada

PI: Ruth Ann Marrie

[PI] CT Perfusion (CTP) for Assessment of Poor Neurological Outcome in Comatose Cardiac Arrest Patients (CANCCAP) – a Prospective Cohort Study

Study sponsor: Manitoba Medical Service Foundation (MMSF)

PI: SA Schaffer, J Shankar

Publications

Peer Reviewed Original Publications

Original Journal Articles Marrie RA, Garland A, Schaffer SA, Fransoo R, Leung S, Yogendran M, Kingwell E, Tremlett H. Traditional risk factors may not explain increased incidence of myocardial infarction in MS. Neurology. 2019 Apr 2; 92(14). Marrie RA, Tremlett H, Kingwell E, Schaffer SA, Yogendran M, Zhu F, Fransoo R, Garland A. Disparities in management and outcomes of myocardial infarction in multiple sclerosis: A matched cohort study. Mult Scler. 2019 Sep 13 PMID: 31517571 Liu S, Zuberi SA, Malik AA, Hiebert BM, Schaffer A, Zieroth S, Cordova FJ. Peripartum Cardiomyopathy Characteristics and Outcomes in Canadian Aboriginal and Non-Aboriginal Women. Can J Cardiol. 2017 Apr;33(4):471-477. doi:10.1016/j.cjca.2016.11.001. Epub 2016 Nov 11. PubMed PMID: 28169090.

Muller Moran HR, Kass M, Ravandi A, Zieroth S, Schaffer SA, Cordova FJ, Pozeg ZI, Arora RC, Singal RK. Diagnosis of Left Ventricular Assist Device Outflow Graft Obstruction Using Intravascular Ultrasound. Circ Heart Fail. 2016 Dec;9(12). pii: e003472. PubMed PMID: 27864303.

Hrymak C, Liu S, Koulack J, Funk DJ, Schaffer SA, Tam JW. Embolus from probable Takotsubo cardiomyopathy: a bedside diagnosis. Can J Cardiol. 2014 Dec;30(12):1732.e9-11. doi: 10.1016/j.cjca.2014.08.008. Epub 2014 Aug 19. PubMed PMID: 25442462.

Schaffer SA, Bercovitch RS, Ross HJ, Rao V. Central sleep apnea interfering with adequate left ventricular filling in a patient with left ventricular assist device. J Clin Sleep Med. 2013 Feb 1;9(2):161-2. doi: 10.5664/jcsm.2416. PubMed PMID: 23372470; PubMed Central PMCID: PMC3544385.

Schaffer SA, Husain S, Delgado DH, Kavanaugh L, Ross HJ. Impact of adjuvanted H1N1 vaccine on cell-mediated rejection in heart transplant recipients. Am J Transplant. 2011 Dec;11(12):2751-4. doi:10.1111/j.1600-6143.2011.03743.x. Epub 2011 Sep 11. PubMed PMID: 21906258.

Schaffer SA, Ross HJ. Everolimus: efficacy and safety in cardiac transplantation. Expert Opin Drug Saf. 2010 Sep;9(5):843-54. doi:10.1517/14740338.2010.511611. Review. PubMed PMID: 20701555.

Schaffer SA, Kirkpatrick ID, Jassal DS, Seifer CM. Multimodality imaging of a pacemaker lead crossing a primum atrial septal defect. Europace. 2010 Mar;12(3):416. doi: 10.1093/europace/eup412. Epub 2010 Jan 3. PubMed PMID:

20047929.

Schaffer SA, Manji RA, Kirkpatrick I, Fang T, Arora RC, Zieroth S, Jassal DS. Negative pressure pulmonary edema in the coronary care unit. Can J Cardiol. 2008 Sep;24(9):e58-9. PubMed PMID: 18787726; PubMed Central PMCID: PMC2643181

Jassal DS, Thakrar A, Schaffer SA, Fang T, Kirkpatrick I, Tam JW, Kashour T. Percutaneous balloon valvuloplasty for pulmonic stenosis: the role of multimodality imaging. Echocardiography. 2008 Feb;25(2):231-5. doi: 10.1111/j.1540-8175.2007.00609.x. Epub 2008 Jan 7. PubMed PMID: 18190536

ABSTRACTS

K.H. Wallace, S.R. Zieroth, S. A. Schaffer, L.A. Schafer, FJ Cordova Perez. Clinical outcomes of adult heart transplant recipients cared for at a low-volume non-transplant center. CCC 2015

Lee C, McIntyre W, Malik A, Schaffer SA, Tam J. Two PE or not two PE: Pulmonary embolism in two patients with pericardial effusions and cardiac tamponade

Parr C. Schaffer SA Association between invasive and non-invasive blood pressure measurements in patients requiring intra-aortic balloon pump augmentation. Internal Medicine Research day 2018, University of Manitoba. Presented by Trainee.

A proposed algorithm to assist first responders in resuscitation of patients with left ventricular assist devices (LVADs). Chu K, SA Schaffer, European Society of Cardiology /Heart Failure 2017 and World Congress on Acute Heart Failure, Paris, France. Presentation by Trainee

Improving Access to HF Care: Pilot Study of a Nurse Practioner Managed-Post Hospital Discharge Transition Clinic. Estrellita Estrella Holder, SA Schaffer, SZ Zieroth, Canadian Cardiovascular Congress 2017. Montreal, QC

INVITED LECTURES

Functional mitral regurgitation: should we fix? Heart Failure Medical and Surgical Program Educational Retreat Day. Niakawa Country Club. May 24, 2017

Left ventricular support devices and GI bleeding, Canadian Society of Gastroenterology and Nurse Associates (CSGNA). Annual Conference. Winnipeg, MB, Sept 29 2016

U of Manitoba Cardiology Grand Rounds, 2012-present

CONFERENCES AND COURSES ATTENDED

Good Clinical Practice (GCP) Guidelines Course, 2019

Canadian Cardiac Sarcoid Symposium, 2018

Heartmate 3, surgical and medical management, 2017

Thoratec: Advanced Management of HeartMate Devices, 2015

Queen’s University online Course in Human Research Participant Protection (CHRPP) 2014

BLS/ACLS Recertification 2014, 2017

Canadian Cardiovascular Congress, 2013

Canadian Cardiovascular Transplant Network 2013

Good Clinical Practice (GCP) Guidelines Course, 2016

NIH Research Ethics Online Course, 2012

Critical Care Canada Forum 2010, 2011, 2012

Canadian Society of Transplant 2010, 2011

Advanced Trauma Life Support (ATLS) Certification 2010

Advanced Medical/Surgical training in HeartMate 2 LVAS. Thoratec Corp, Johns Hopkins University, 2009

ACLS Recertification 2005

ACLS 2003

Safe handling and ethical use of animals in experimental research (22.450), Department of Zoology, University of Manitoba, 1998

PUBLIC AWARENESS

Heart Failure Awareness Day, Public Education Day, 2012- 2019

Lets talk about heart failure. Heart Failure Awareness day, Winnipeg, MB.

TEACHING AND EDUCATION ACTIVITIES

Teaching:

Teaching and Education Activities > Teaching

Cardiology Fellow, Academic Half Day

-Heart Transplantation, October 27 2016

-Cardiogenic Shock July 2014, August 2016, June 2018

-Simulation Scenarios June 2017, November 2017, June 2018, September 2019

-Ventilation strategies for cardiac patients, March 2017

-Critical illness and Non-cardiac complications in the CCU patient

Internal Medicine Academic Halfday

-Cardiomyopathies and Cardiogenic Shock, 2019

Critical Care Academic Halfday

-Cardiogenic Shock, 2015

-Non-invasive assessment of Cardiac output, 2015

-Immunosuppression and Infectious complications in the solid organ transplant recipient, Feb 14, 2018

-Arrhythmias in the ICU, October 30, 2019

ICU Clinical Assistant in Training

-How to write consultations, March 2017

-Heart Failure, June, 2016

-Cardiogenic Shock, June 29, 2016

UGME/Medical School

-UGME Academic Half day, Chest pain and angina, April 26 2018, October 3 2019

-UGME Academic Half day, Heart Failure April 26, 2018, October 3 2019

-ECG

-Physical Exam Session

-Med 1 Block 3 Cardiovascular Tutorial Module 2 - CV217 - Heart Failure 3. April 22, 2016

-Med 1 CV 135, November 22, 2017

-Med I CV228, Heart Failure III, May 12, 2017

-Med 1 Block 3 Cardiovascular Tutorial CV 211 - Valvular Heart Disease V April 15, 2016

-Med 1 Block 3 Cardiovascular CV235, Ischemic Heart Disease VI, May 17, 2017

- Med 1 Module 1 Cardiovascular drugs VI , Nov 20, 2019

- Med 1 Module 3 CV126, November 4, 2019

Clinical Supervision:

Cardiology Fellows

Rotating sub-specialty Residents

Clinical associates in training

III. COMMITTEES, ADMINISTRATION AND CPAS

Administrative Activities

INTERNATIONAL/NATIONAL/PROVINCIAL/LOCAL (list in this order)

Canadian Blood Services, Heart Transplant Advisory Committee Executive Canadian Cardiac Transplant Network, member at large

Canadian Heart Failure Society, Member at large

St. Boniface Hospital VAP prevention committee

St. Boniface Hospital ICU QI committee

St. Boniface Hospital ACCU QI committee

Director, St. Boniface ACCU

Director, HSC CCU

Low Risk STEMI working group