Stem Cell Biology and it Application to Biotechnology Stem Cell
Stem cell timeline
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Transcript of Stem cell timeline
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Nanog, which helps keep cells pluripotent was discovered by Ian
Chambers, University of Edinburgh
SSCN launched at event addressed by Geron Corp’s CEO, Tom Okarma
First mammal cloned from an adult (somatic) cell - Dolly the sheep is
born at the Roslin Institute
Virus free induction of iPS cells by Keisuke Kaji (Edinburgh) and
Andras Nagy (Toronoto)
First in man study: ReNeuron’s neural stem cells in clinical study at
Southern General Hospital, Glasgow
1956 1961 1978 1981 1988 1995 1998 2000 2006 2007 2008 2010
1996 2003 2009 2011
Scottish Centre for Regenerative Medicine opens in Edinburgh at the
at bioQuarter (near RIE)
First bone marrow transplant performed in US
James Till and Ernest McCulloch prove the existence of stem cells
in the bone marrow
Stem cells are discovered in human cord blood
First embryonic stem cells are derived from a mouse blastocyst
First embryonic stem cell line derived from a non-human primate
First cord blood transplant performed in a patient with Fanconi anemia
James Thomson publishes the first paper in Science describing hESCs
Osiris Therapeutics (US), began their 1st trial using mesenchymal stem cells
(MSCs) in bone marrow transplants
First stem cells derived from a cloned embryo in a mouse
Yamanaka and colleagues at Kyoto University create the first iPS cells created from mouse somatic cells.
Thomson, Yamanaka and others publish the creation of iPS cells
from humans
Harvard researchers publish first disease specific iPS lines for
diseases including Parkinson’s and juvenile diabetes
Scientists at Stanford University directly reprogram fibroblasts to
neurons without needing to return the cells to pluripotency first.
Geron (US) receives clearance to begin world’s first human clinical trial
of hESC based therapy for acute spinal cord injury
Advanced Cell Technology (US) granted approval to proceed with clinical trials with hESC derived
treatment for a rare type of blindness.
Stem cell discovery timeline
Created by SSCN:
based on original work done by the Australian Stem Cell Centre
Image ©
The Roslin Institute
Image © PhotoGraphics, University Health Network